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https://www.readbyqxmd.com/read/28903508/effect-of-paritaprevir-ritonavir-ombitasvir-dasabuvir-and-ledipasvir-sofosbuvir-regimens-on-survival-compared-with-untreated-hepatitis-c-virus-infected-persons-results-from-erchives
#1
Adeel Ajwad Butt, Peng Yan, Tracey G Simon, Abdul-Badi Abou-Samra
Background: Interferon-based regimens are associated with a substantial survival benefit for persons infected with hepatitis C virus (HCV). Survival data with direct-acting antiviral agents are not available. We conducted this study to quantify the effect of paritaprevir/ritonavir, ombitasvir, dasabuvir (PrOD) and ledipasvir/sofosbuvir (LDV/SOF) regimens upon mortality. Methods: In the Electronically Retrieved Cohort of HCV Infected Veterans (ERCHIVES), a well-established national cohort of HCV-infected Veterans, we identified HCV-infected persons initiated on PrOD or LDV/SOF, excluding those with human immunodeficiency virus, hepatitis B surface antigen positivity, hepatocellular carcinoma, or missing HCV RNA or FIB-4 scores...
September 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28875760/redo-surgery-using-intralase-femtosecond-laser-for-treating-a-decentered-laser-in-situ-keratomileusis-flap
#2
Yulin Lei, Jie Hou, Xiuyun Zheng
Objective Decentered flaps are rarely reported after femtosecond laser-assisted in situ keratomileusis flap procedures. We present a patient with a decentered flap after preparation of a corneal flap using the Femto LDV technique. Methods The 22-year-old man required a redo operation because of a decentered corneal flap. It was performed the same day at the patient's insistence and with his consent. The new corneal flap for the redo surgery was prepared using the femtosecond laser technique and IntraLase. Results Uncorrected visual acuity for each eye was 1...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28875250/effect-of-iris-registration-on-outcomes-of-femtolasik-for-myopia-and-myopic-astigmatism
#3
Mohammad Ghoreishi, Zahra Naderi Beni, Afsaneh Naderi Beni, Farzan Kianersi
PURPOSE: To compare the visual and refractive outcomes after FEMTOLASIK with and without iris registration. METHODS: In this randomized, prospective, comparative, contralateral eye study, 118 eyes of 59 patients with myopia and myopic astigmatism underwent LASIK using the Femto LDV femtosecond laser (160 µm) and the MEL80 with or without iris registration. For each patient, iris registration FEMTOLASIK was performed on one eye and non-iris registration FEMTOLASIK was performed on the other eye, assigned at random...
September 5, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28873174/performing-reliable-lens-capsulotomy-in-the-presence-of-corneal-edema-with-a-femtosecond-laser
#4
Geraint P Williams, Benjamin L George, Yoke R Wong, Gary H F Yam, Marcus Ang, Shian C Tay, Jodhbir S Mehta
Purpose: To determine the effects of the Ziemer LDV Z8 liquid interface femtosecond laser platform during capsulotomy under different energy settings in the presence of corneal edema. Methods: Cadaveric porcine eyes (n = 36) employed at less than 6 and greater than 24 post enucleation hours to simulate clear/edematous corneas, underwent capsulotomy with the Ziemer LDV Z8 femtosecond laser (5-mm diameter, energy 90%, 130%, or 150%). Lens capsules were removed for evaluation by scanning electron microscopy and rupture strengths determined by the single column universal testing system...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28834042/changes-in-serum-lipid-profiles-caused-by-three-regimens-of-interferon-free-direct-acting-antivirals-for-patients-infected-with-hepatitis-c-virus
#5
Takako Inoue, Takaaki Goto, Etsuko Iio, Kayoko Matsunami, Kei Fujiwara, Noboru Shinkai, Kentaro Matsuura, Takeshi Matsui, Shunsuke Nojiri, Yasuhito Tanaka
AIM: As described previously, serum low-density lipoprotein cholesterol (LDL-C) increases during treatment of chronic hepatitis C (CHC) with interferon-free direct-acting antivirals (DAAs). We sought to compare the changes of serum lipid profiles caused by three regimens. METHODS: A total of 216 CHC patients were enrolled. Among 170 patients infected with HCV genotype 1b, 85 received daclatasvir plus asunaprevir (DCV/ASV) and 85 received sofosbuvir plus ledipasvir (SOF/LDV)...
August 19, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28833932/nonstructural-protein-5a-ns5a-resistance-profile-in-patients-with-chronic-hepatitis-c-treated-with-ledipasvir-containing-regimens-without-sofosbuvir
#6
Kathryn M Kitrinos, Amoreena C Corsa, Angela Worth, Charlotte Hedskog, Diana Brainard, Michael D Miller, Hongmei Mo
The study aimed to evaluate the effects of baseline hepatitis C virus (HCV) NS5A resistance-associated substitutions (RASs) on sustained virologic response to ledipasvir (LDV)-containing regimens in the absence of sofosbuvir (SOF) in patients with HCV genotype (GT) 1 infection across 6 phase 2 clinical studies. We analyzed data from 1103 patients who received either LDV+vedroprevir (NS3 PI)+tegobuvir (NS5B inhibitor)±ribavirin or LDV+ribavirin+pegylated interferon. Population sequencing of HCV NS5A was performed at baseline and at virologic failure from patient plasma samples...
August 20, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28830254/modelling-the-fiscal-costs-and-benefits-of-alternative-treatment-strategies-in-the-united-kingdom-for-chronic-hepatitis-c
#7
Mark P Connolly, Nikos Kotsopoulos, Andrew Ustianowski
BACKGROUND: Hepatitis C (HCV) infection causes substantial direct health costs, but also impacts broader societal and governmental costs, such as tax revenue and social protection benefits. We investigated the broader fiscal costs and benefits of curative interventions for chronic Hepatitis C (CHC) that allow individuals to avoid long-term HCV attributed health conditions. METHODS: A prospective cohort model, assessing the long-term fiscal consequences of policy decisions, was developed for HCV infected individuals, following the generational accounting analytic framework that combines age-specific lifetime gross taxes paid and governmental transfers received (i...
August 23, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28827512/efficacy-and-safety-of-sofosbuvir-based-regimens-for-treatment-in-chronic-hepatitis-c-genotype-1-patients-with-moderately-impaired-renal-function
#8
Hyun Phil Shin, Ji-Ae Park, Blaire Burman, Richard A Kozarek, Asma Siddique
Background/Aims: Treatment of chronic hepatitis C virus (HCV) infection in patients with chronic kidney disease (CKD) is essential. The availability of sofosbuvir (SOF) has dramatically improved overall HCV cure rates, however there is insufficient data regarding its use in patients with CKD. We evaluated SOF in patients with hepatitis C genotype 1 (G1) and moderately impaired renal function. Methods: We retrospectively reviewed all patients treated with a SOF-based regimen from December 2013 through September 2015 at Virginia Mason Medical Center...
August 22, 2017: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/28814519/extracellular-matrix-proteins-mediate-hiv-1-gp120-interactions-with-%C3%AE-4%C3%AE-7
#9
David Plotnik, Wenjin Guo, Brad Cleveland, Priska von Haller, Jimmy K Eng, Miklos Guttman, Kelly K Lee, James Arthos, Shiu-Lok Hu
Gut-homing α4β7(high) CD4(+) T lymphocytes have been shown to be preferentially targeted by Human Immunodeficiency Virus-1 (HIV), and are implicated in HIV pathogenesis. Previous studies demonstrated that HIV envelope protein gp120 binds and signals through α4β7, and that this likely contributes to the infection of α4β7(high) T cells and promotes cell-to-cell virus transmission. Structures within the second variable loop (V2) of gp120, including the tripeptide motif LDV/I, are thought to mediate gp120-α4β7 binding...
August 16, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28809742/treatment-of-chronic-hcv-infection-with-the-new-direct-acting-antivirals-daa-first-report-of-a-real-world-experience-in-southern-brazil
#10
Hugo Cheinquer, Hoel Sette-Jr, Fernando H Wolff, Alexandre de Araujo, Silvia Coelho-Borges, Silvia R P Soares, Mauricio F A Barros
INTRODUCTION AND AIM: There is almost no data regarding the efficacy of direct acting antivirals (DAAs) therapy in Brazil. The aim of this historical cohort study is to describe the sustained virologic response (SVR) rate among real-world compensated chronic hepatitis C patients in three hepatology centers from Southern Brazil. MATERIALS AND METHODS: Patients were included if they had at least 12 weeks follow-up after the end of therapy. Patients that were lost to follow-up or had treatment prematurely interrupted for any reason were considered treatment failure in this intention to treat analysis...
September 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28795982/treatment-of-patients-with-hepatitis-c-virus-infection-genotype-4-with-ledipasvir-sofosbuvir-in-the-liver-transplant-setting
#11
Faisal Abaalkhail, Hussein Elsiesy, Hany Elbeshbeshy, Mohamed Shawkat, Sarra Yousif, Waheed Ullah, Saleh Alabbad, Ahmed Al-Jedai, Aziza Ajlan, Dieter Broering, Sammy Saab, Mohammed Al Sebayel, Waleed Al-Hamoudi
BACKGROUND: Hepatitis C virus infection is a major cause of liver cirrhosis and hepatocellular carcinoma and the leading indication for liver transplantation. In the Middle East, genotype 4 HCV infection is the most common genotype. However, limited data exists on the treatment of genotype-4 in the liver transplant setting. We evaluated the safety and efficacy of ledipasvir-sofosbuvir (LDV/SOF) in treating HCV genotype-4 infected patients with cirrhosis or postliver transplantation. METHODS: This prospective, single-arm, observational study includes cohort of patients with cirrhosis before liver transplantation (Cohort A) and a cohort of postliver transplantation patients (Cohort B)...
August 9, 2017: Transplantation
https://www.readbyqxmd.com/read/28783205/successful-treatment-of-chronic-hepatitis-c-with-ground-ledipasvir-sofosbuvir-in-a-patient-with-crohn-s-disease-and-short-bowel-syndrome
#12
Johann von Felden, Christoph Scheurich, Jin Yamamura, Diana M Brainard, Erik Mogalian, Ansgar W Lohse, Julian Schulze-Zur-Wiesch
We read the comprehensive review by Gitto et al. entitled 'NS5A inhibitors for the treatment of hepatitis C infection' (CHC) with great interest (1). Indeed, the development of direct acting antivirals (DAAs) now enables successful treatment of formerly difficult-to-treat patient populations (e.g. cirrhosis or chronic kidney disease). However, little is known about the use of DAAs in patients with short bowel syndrome, e.g. following inflammatory bowel disease (IBD), because these patients are yet excluded from clinical trials (2)...
August 7, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28772431/inspection-of-piezoceramic-transducers-used-for-structural-health-monitoring
#13
Inka Mueller, Claus-Peter Fritzen
The use of piezoelectric wafer active sensors (PWAS) for structural health monitoring (SHM) purposes is state of the art for acousto-ultrasonic-based methods. For system reliability, detailed information about the PWAS itself is necessary. This paper gives an overview on frequent PWAS faults and presents the effects of these faults on the wave propagation, used for active acousto-ultrasonics-based SHM. The analysis of the wave field is based on velocity measurements using a laser Doppler vibrometer (LDV). New and established methods of PWAS inspection are explained in detail, listing advantages and disadvantages...
January 16, 2017: Materials
https://www.readbyqxmd.com/read/28765697/eight-week-ledipasvir-sofosbuvir-in-non-cirrhotic-treatment-na%C3%A3-ve-hepatitis-c-genotype-1-patients-with-hepatitis-c-virus-rna-6-million-single-center-real-world-effectiveness-and-safety
#14
Nyan L Latt, Beshoy T Yanny, Derenik Gharibian, Rita Gevorkyan, Amandeep K Sahota
AIM: To evaluate sustained viral response (SVR) of 8-wk ledipasvir/sofosbuvir therapy among non-cirrhotic, genotype-1 hepatitis C virus (HCV) patients with RNA < 6 million IU/mL. METHODS: We performed a retrospective cohort study to examine SVR rates, predictors of treatment failure and safety analysis of 8-wk ledipasvir/sofosbuvir (LDV/SOF) therapy among non-cirrhotic, genotype 1 HCV patients with viral load < 6 million IU/mL. Primary outcome was an achievement of SVR at 12 wk after treatment...
July 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28756648/objective-assessment-of-hearing-during-second-stage-of-tympanoplasty-surgical-technique-and-measurement-methodology-presented-in-ten-patients
#15
Kazimierz Niemczyk, Krzysztof Morawski, Rafael Delgado, Antoni Bruzgielewicz, Magdalena Lachowska
In this paper, a complete integrated method of intraoperative monitoring of hearing (IOMH) during ossiculoplasty performed via posterior tympanotomy is presented. The method integrates auditory steady state responses (ASSR) with Laser-Doppler Vibrometry (LDV) and allows intraoperative optimization of ossicular prosthesis positioning and coupling. Both ASSR and LDV are acquired simultaneously. The results of the integrated measurements are analyzed and evaluated automatically on-line which makes this strategy unaffected by individual differences in interpretations of collected recordings...
July 30, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28704381/sofosbuvir-based-treatment-of-chronic-hepatitis-c-genotype-3-infections-a-scandinavian-real-life-study
#16
Olav Dalgard, Ola Weiland, Geir Noraberg, Lars Karlsen, Lars Heggelund, Martti Färkkilâ, Ulla Balslev, Erika Belard, Anne Øvrehus, Mette Skalshøi Kjær, Henrik Krarup, Birgit Thorup Røge, Sofie Hallager, Lone G Madsen, Alex Lund Laursen, Martin Lagging, Nina Weis
BACKGROUND AND AIMS: Chronic hepatitis C virus (HCV) genotype 3 infection with advanced liver disease has emerged as the most challenging to treat. We retrospectively assessed the treatment outcome of sofosbuvir (SOF) based regimes for treatment of HCV genotype 3 infections in a real life setting in Scandinavia. METHODS: Consecutive patients with chronic HCV genotype 3 infection were enrolled at 16 treatment centers in Denmark, Sweden, Norway and Finland. Patients who had received a SOF containing regimen were included...
2017: PloS One
https://www.readbyqxmd.com/read/28677020/treatment-discontinuation-adherence-and-real-world-effectiveness-among-patients-treated-with-ledipasvir-sofosbuvir-in-the-united-states
#17
Amy Puenpatom, Michael Hull, Jeffrey McPheeters, Kay Schwebke
INTRODUCTION: Ledipasvir/sofosbuvir (LDV/SOF) for hepatitis C virus (HCV) treatment provides an oral interferon-free treatment regimen with high rates of sustained virologic response (SVR). This study assessed treatment discontinuation, factors associated with treatment completion, and real-world effectiveness. METHODS: Patients with HCV treated with LDV/SOF between October 2014 and June 2015 and enrolled in a large US health plan were identified. Expected treatment duration was calculated based on IDSA/AASLD treatment guidelines and US labels using data for genotype, initial treatment regimen, baseline cirrhosis, and prior treatments...
July 4, 2017: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/28671917/experimental-simulation-of-clinical-borderline-situations-in-temporal-bone-specimens-after-ossiculoplasty
#18
Till F Jakob, Jan Kromeier, Tobias Baumann, Jens Pfeiffer, Marcus Neudert, Roland Laszig, Thomas Zahnert, Christian Offergeld
OBJECTIVES: One reason for insufficient hearing improvement with a distinct air-bone gap after ossiculoplasty with implantation of partial or total ossicular replacement prostheses can be the dislocation or minimal shifting of the prosthesis. The aim of this study was the simulation of common clinical borderline situations with minimal shifting of the prosthesis in temporal bone specimens after ossiculoplasty. It was furthermore the goal to identify these specific situations through imaging by cone beam computed tomography (cbCT) and direct visual inspection using the operation microscope...
June 30, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28671872/camera-based-assessment-of-arterial-stiffness-and-wave-reflection-parameters-from-neck-micro-motion
#19
Andreia Vieira Moço, Luis Albert Zavala Mondragon, Wenjin Wang, Sander Stuijk, Gerard de Haan
The feasibility of camera-based extraction of the carotid distension waveforms offers the prospect of a user-friendly alternative to Laser Doppler Velocimetry (LDV) or accelerometry-based systems. Upon supplementary calibration of vessel wall displacement to arterial pressure, our system may also be an appealing alternative to applanation tonometry for extracting cardiac-related features from the central pulse pressure waveform. This paper describes the application of camera-based micro-motion imaging to extract health-related features from the contour of the carotid displacement waveform...
July 3, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28666703/a-comparative-study-of-med-el-fmt-attachment-to-the-long-process-of-the-incus-in-intact-middle-ears-and-its-attachment-to-disarticulated-stapes-head
#20
Tao Chen, Liu-Jie Ren, Dong-Ming Yin, Jia Li, Lin Yang, Pei-Dong Dai, Tian-Yu Zhang
The Vibrant Soundbridge(©) (VSB) active middle-ear implant provides an effective treatment for mild-to-severe sensorineural hearing loss in the case of normal middle ear anatomy and mixed hearing loss in middle ear malformation. The VSB floating mass transducer (FMT), with proper couplers, can be installed on various structures of the ossicular chain, e.g., the short and long process of the incus, the stapes head, and the stapes footplate. A long process (LP) coupler is most commonly used for FMT attachment to the long process of the incus with intact ossicular chain, while CliP and Bell couplers are two standardized and reliable methods for FMT attachment to the stapes head with missing incus and malleus...
June 23, 2017: Hearing Research
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