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E B Tapper, B R Bacon, M P Curry, D T Dieterich, S L Flamm, L E Guest, K V Kowdley, Y Lee, N C Tsai, Z M Younossi, N H Afdhal
Early data regarding the "real-world" experience with novel therapies for hepatitis C (HCV) are encouraging. Data are still limited, however, regarding real-world rates of sustained virologic response (SVR) for ledipasvir-sofosbuvir (LDV-SOF), particularly for patients with prior treatment failure. We performed a retrospective cohort study of 1597 patients with chronic genotype 1 HCV who were treated using 12 weeks of the following regimens LDV-SOF±ribavirin (RBV) (n=1521 without RBV, n=76 with RBV). The primary outcome was SVR-determined at 12 weeks in an intention-to-treat design...
October 11, 2016: Journal of Viral Hepatitis
Satoru Hashimoto, Hiroshi Yatsuhashi, Seigo Abiru, Kazumi Yamasaki, Atsumasa Komori, Shinya Nagaoka, Akira Saeki, Shinjiro Uchida, Shigemune Bekki, Yuki Kugiyama, Kazuyoshi Nagata, Minoru Nakamura, Kiyoshi Migita, Kazuhiko Nakao
BACKGROUND & AIM: We performed lipid analyses at the early period of therapy in patients with chronic hepatitis C who underwent interferon (IFN)-free direct-acting antiviral (DAA) treatment, and we attempted to identify the factors that contributed to a rapid increase in the patients' serum low-density lipoprotein cholesterol (LDL-C) concentration. METHODS: We retrospectively analyzed the cases of 100 consecutive patients with HCV infection treated at the National Hospital Organization Nagasaki Medical Center: 24 patients underwent daclatasvir (DCV) and asunaprevir (ASV) combination therapy (DCV/ASV) for 24 weeks, and the other 76 patients underwent ledipasvir and sofosbuvir combination therapy (LDV/SOF) for 12 weeks...
2016: PloS One
R J Wong, M T Nguyen, H N Trinh, A Huynh, M T Ly, H A Nguyen, K K Nguyen, J Yang, R T Garcia, B Levitt, E da Silveira, R G Gish
Sofosbuvir/ledipasvir (SOF/LDV) is the first all-oral ribavirin-free treatment approved for chronic hepatitis C virus (HCV) genotype 6, offering a safe and highly efficacious treatment option. Large studies evaluating real-world outcomes of this regimen are lacking. We aim to evaluate real-world treatment outcomes for HCV genotype 6. A retrospective cohort study evaluated 65 adults (age ≥18) with chronic HCV genotype 6 treated with SOF/LDV without ribavirin at a community gastroenterology clinic in the United States from November 2014 to May 2016...
September 27, 2016: Journal of Viral Hepatitis
Christoph R Werner, Julia M Schwarz, Daniel P Egetemeyr, Robert Beck, Nisar P Malek, Ulrich M Lauer, Christoph P Berg
AIM: To gather data on the antiviral efficacy and safety of second generation direct acting antiviral (DAA) treatment with respect to sustained virological response (SVR) 12 wk after conclusion of treatment, and to determine predictors of SVR12 in this setting. METHODS: Two hundred and sixty patients treated with SOF combination partners PR (n = 51), R (n = 10), SMV (n = 30), DCV (n = 81), LDV (n = 73), or 3D (n = 15). 144/260 were pre-treated, 89/260 had liver cirrhosis, 56/260 had portal hypertension with platelets < 100/nL, 25/260 had a MELD score ≥ 10 and 17/260 were post-liver transplantation patients...
September 21, 2016: World Journal of Gastroenterology: WJG
Aneta Michna, Zbigniew Adamczyk, Kamila Sofińska, Katarzyna Matusik
The deposition of poly(amido amine) dendrimers on mica at various pHs was studied by the atomic force microscopy (AFM) and in situ streaming potential measurements. Bulk characteristics of dendrimers were acquired by using the dynamic light scattering (DLS) and the laser Doppler velocimetry (LDV). The hydrodynamic radius derived from DLS measurements was 5.2nm for the ionic strength of 10(-2)M and pH range 4-10. The electrophoretic mobility, the zeta potential and the number of electrokinetic charges per molecule were derived as a function of pH from the LDV measurements...
January 1, 2017: Journal of Colloid and Interface Science
Takayuki Ohtomo, Seiichi Sudo, Kenju Otsuka
We observed intermittent modulation by scattered light from a single submicrometer particle moving in the flow channel using a self-mixing microchip Yb:YAG laser Doppler velocimeter (LDV) under lateral beam access. The Doppler-shift frequency chirping (i.e., velocity change) was identified in accordance with a particle passage through the beam focus. Single particle counting, which obeys the Poisson distribution, was performed successfully over a long period of time. The experimental results have been reproduced by a numerical simulation...
September 20, 2016: Applied Optics
B Njei, T R McCarty, B E Fortune, J K Lim
BACKGROUND: Recurrence of hepatitis C virus (HCV) following liver transplantation (LT) is universal for those with ongoing viraemia and is associated with higher rates of allograft failure and death. However, the optimal timing of HCV treatment for patients awaiting transplant remains unclear. AIM: To evaluate the comparative cost-effectiveness of treating HCV pre-LT vs. post-LT (pre-emptive or after HCV recurrence). METHODS: A Markov state-transition model was created to simulate the progression of a cohort of HCV-genotype 1 or 4 cirrhotic patients from the time of transplant listing until death...
November 2016: Alimentary Pharmacology & Therapeutics
A Igarashi, W Tang, I Guerra, L Marié, S Cure, M Lopresti
OBJECTIVE: Hepatitis C is the result of a ribonucleic acid (RNA) virus (hepatitis C virus; HCV). The Japan Society of Hepatology (JSH) estimated that 1.5-2 million people in Japan carry HCV. Six major HCV genotypes (GT) and a large number of subtypes have been described in the literature. In Japan, around 70% to 80% of people are infected with HCV genotype 1b. The progress of the disease primarily affects the liver and may lead to liver cirrhosis, hepatocellular carcinoma (HCC) and death...
September 9, 2016: Current Medical Research and Opinion
Marta Kujda, Zbigniew Adamczyk, Michał Ciesla
Human serum albumin dimer (dHSA) enhances the accumulation and retention of anti-tumor drugs. In this work, monolayers of dHSA on polystyrene microparticles were prepared and thoroughly characterized. The changes in the electrophoretic mobility of microparticles upon the addition of controlled amounts of dHSA were measured using Laser Doppler Velocimetry (LDV) technique. These dependencies were quantitatively interpreted in terms of the 3D electrokinetic model. This allowed to determine the coverage of dHSA on microparticles under in situ conditions...
August 23, 2016: Colloids and Surfaces. B, Biointerfaces
Qi Hu, Jacob Song Kiat Lim, Huan Liu, Yu Fu
Photoacoustic/photothermal spectroscopy is an established technique for trace detection of chemicals and explosives. However, prior sample preparation is required and the analysis is conducted in a sealed space with a high-sensitivity microphone or a piezo sensor coupled with a lock-in amplifier, limiting the technique to applications in a laboratory environment. Due to the aforementioned requirements, traditionally this technique may not be suitable for defense and security applications where the detection of explosives or hazardous chemicals is required in an open environment at a safe standoff distance...
August 22, 2016: Optics Express
Hamid R Djalilian, Hossein Mahboubi, Yarah M Haidar, Peyton Paulick, Mark W Merlo, Mark Bachman
OBJECTIVES/HYPOTHESIS: To develop a novel completely-in-the-canal device capable of directly driving the tympanic membrane (TM) and ossicular chain from the ear canal. STUDY DESIGN: Development and feasibility study. METHODS: A voice coil actuator design was developed to drive the TM. Bench testing of the device using laser Doppler vibrometry (LDV) and sound recording was performed. Temporal bone studies using LDV were performed using different designs of the contact tip-TM interface to find the most efficient method of sound transmission...
August 22, 2016: Laryngoscope
Ryan M Kwok, Joseph Ahn, Thomas D Schiano, Helen S Te, Darryn R Potosky, Amber Tierney, Rohit Satoskar, Suzanne Robertazzi, Colleen Rodigas, Michelle Lee Sang, Joshua Wiegel, Neal Patel, Janet Gripshover, Mohamed A Hassan, Andrea Branch, Coleman I Smith
: Hepatitis C virus (HCV) recurrence after liver transplant (LT) is associated with worse outcomes. Ledipasvir and sofosbuvir (LDV/SOF) has been approved for HCV treatment after LT, but there is limited data on the effectiveness and safety of LDV/SOF in the "real world" setting. This multi-center study is the largest report to date, on the effectiveness and safety of LDV/SOF in the post-LT setting. Two hundred and four patients (72% male, 68% Caucasian, 66% genotype 1a, 21% METAVIR F3-F4, 49% treatment-experienced) were treated with LDV/SOF...
August 20, 2016: Liver Transplantation
Zobair M Younossi, Maria Stepanova, Masao Omata, Masashi Mizokami, Mercedes Walters, Sharon Hunt
The interferon (IFN)-free regimens for chronic hepatitis C (CHC) have high efficacy and superior health-related quality of life (HRQOL) in European/North American patients. The impact of these regimens on HRQOL of the Japanese CHC patients is not known.The Short Form-36 was administered before, during, and after treatment to CHC patients with genotype 1 treated with ledipasvir/sofosbuvir ± ribavirin (LDV/SOF ± RBV) for 12 weeks and genotype 2 treated with SOF + RBV for 12 weeks in clinical trials...
August 2016: Medicine (Baltimore)
Elliot B Tapper, Bruce R Bacon, Michael P Curry, Douglas T Dieterich, Steven L Flamm, Lauren E Guest, Kris V Kowdley, Yoori Lee, Naoky C Tsai, Zobair M Younossi, Nezam H Afdhal
: Many patients with chronic hepatitis C virus (HCV) are on prolonged proton-pump inhibitor (PPI) therapy and wish to remain on PPI therapy once treatment for HCV starts. A preliminary report recently suggested decrease rates of sustained virological response (SVR) for patients taking concomitant PPI and ledipasvir/sofosbuvir (LDV/SOF). We sought to determine the effect of PPI use on the rate of SVR in a real-world cohort of 1,979 patients with chronic HCV treated with LDV/SOF. We collected clinical data and pharmacy dispensing records on patients taking 8, 12, or 24 weeks of LDV/SOF ± ribavirin (RBV)...
August 17, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Siegfried Mariacher, Martina Ebner, Anna-Maria Seuthe, Kai Januschowski, Ciprian Ivanescu, Natalia Opitz, Peter Szurman, Karl Thomas Boden
PURPOSE: To evaluate clinical data and outcomes after femtosecond laser-assisted cataract surgery with the recently introduced low-energy Femto LDV Z8 laser during a 3-month follow-up. SETTING: Knappschaft Eye Clinic Sulzbach, Knappschaft Hospital Saar GmbH, Sulzbach, Germany. DESIGN: Consecutive case series. METHODS: Femtosecond laser-assisted cataract surgery was performed using the low-energy femtosecond laser. Clinical data including objective refraction, corrected distance visual acuity, central corneal thickness (CCT), endothelial cell count (ECC), and aqueous flare were evaluated 1 day, 1 week, 4 weeks, and 3 months postoperatively...
August 2016: Journal of Cataract and Refractive Surgery
J T Stahmeyer, S Rossol, F Bert, S Liersch, C Krauth
The treatment of chronic hepatitis C has considerably changed with the introduction of recent direct acting antivirals. These antivirals have sustained virologic response (SVR) rates above 90 % as well as reduced toxicity and treatment duration. Therefore, current German guidelines recommend these interferon-free regimens as first-choice treatment. Nevertheless, recent developments were accompanied by a significant increase in treatment costs, which led to extensive discussions on reasonable pharmaceutical prices...
August 2016: Zeitschrift Für Gastroenterologie
Yanmei Li, Yanfang Wang, Jingjie Ye, Jiang Yuan, Yinghong Xiao
The natural abundance of cell adhesion sequences, RGD (Arg-Gly-Asp) and LDV (Leu-Asp-Val) in the keratins make them suitable as biomaterials for tissue engineering applications. Herein, keratins were coelectrospun with poly(ε-caprolactone)(PCL) at the ratio of 9/1, 8/2, and 7/3 to afford nanofibrous mats. The resulting mats were surface-characterized by ATR-FTIR, SEM, WCA, and XPS. Cell attachment data showed that NIH 3T3 cells adhered more to the PCL/keratin nanofibrous mats than the pristine PCL mats. The MTT assay revealed that the PCL/keratin mats had improved cell viability...
November 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
Elliot B Tapper, Michael S Hughes, Maria Buti, Jean-Francois Dufour, Steve Flamm, Saima Firdoos, Michael P Curry, Nezam H Afdhal
BACKGROUND: Ledipasvir/sofosbuvir (LDV/SOF) has demonstrated high efficacy, safety and tolerability in HCV-infected patients. There is limited data, however, regarding the optimal timing of therapy in the context of possible liver transplantation (LT). METHODS: We compared the cost-effectiveness of 12 weeks of HCV therapy before or after LT or nontreatment using a decision analytical microsimulation state-transition model for a simulated cohort of 10 000 patients with HCV Genotype 1 or 4 with Child B or C cirrhosis...
August 4, 2016: Transplantation
Kristen L Bunnell, Sonia Vibhakar, Robert C Glowacki, Maureen A Gallagher, Albert M Osei, Gregory Huhn
Direct-acting antivirals (DAAs) have revolutionized the treatment of hepatitis C virus (HCV) infection, with superior efficacy and safety compared to interferon-based therapies. Despite these improvements, drug interactions with DAAs exist and may be clinically relevant in human immunodeficiency virus (HIV)-coinfected patients. We present a case of nephrotoxicity associated with concomitant use of tenofovir disoproxil fumarate (TDF) and ledipasvir-sofosbuvir (LDV-SOF). A 56-year-old woman with HIV infection who had been taking efavirenz/tenofovir/emtricitabine (EFV/TDF/FTC) for 6 years developed acute kidney injury 8 weeks after initiating LDV-SOF for the treatment of HCV infection...
September 2016: Pharmacotherapy
Dong Ji, Guo-Feng Chen, Cheng Wang, Yu-Dong Wang, Qing Shao, Bing Li, Jun Zhao, Shao-Li You, Jin-Hua Hu, Jia-Liang Liu, Xiao-Xia Niu, Jing Chen, Lei Lu, Vanessa Wu, George Lau
BACKGROUND: Treatment-experienced chronic hepatitis C (CHC) genotype (GT) 1b represents a major medical burden in China. We evaluate the efficacy, safety and cost-effectiveness of ribavirin (RBV)-free pan-oral direct-acting antivirals (DAAs) in treatment-experienced Chinese with GT1b CHC, including patients with cirrhosis. METHODS: One hundred forty treatment-experienced GT1b CHC Chinese with and without cirrhosis were included in this study. Ninety-four patients were treated with either daclatasvir (DCV, 60 mg)-sofosbuvir (SOF, 400 mg) (group 1, n = 46) or ledipasvir (LDV, 90 mg)-SOF (400 mg) (group 2, n = 48) for 12 weeks...
September 2016: Hepatology International
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