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Neurocritical care randomized

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https://www.readbyqxmd.com/read/27742889/reappraisal-of-the-reference-levels-for-energy-metabolites-in-the-extracellular-fluid-of-the-human-brain
#1
Angela Sánchez-Guerrero, Gemma Mur-Bonet, Marian Vidal-Jorge, Darío Gándara-Sabatini, Ivette Chocrón, Esteban Cordero, Maria-Antonia Poca, Katharine Mullen, Juan Sahuquillo
Cerebral microdialysis is widely used in neurocritical care units. The goal of this study was to establish the reference interval for the interstitial fluid concentrations of energy metabolites and glycerol by using the extrapolation to zero-flow methodology in anesthetized patients and by constant perfusion at 0.3 µL/min in awake patients. A CMA-71 probe was implanted during surgery in normal white matter of patients with posterior fossa or supratentorial lesions, and the perfusion flow rate was randomized to 0...
October 14, 2016: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27686460/esicm-lives-2016-part-two-milan-italy-1-5-october-2016
#2
S Sivakumar, F S Taccone, K A Desai, C Lazaridis, M Skarzynski, M Sekhon, W Henderson, D Griesdale, L Chapple, A Deane, L Williams, R Strickland, K Lange, D Heyland, M Chapman, M J Rowland, P Garry, J Westbrook, R Corkill, C A Antoniades, K T Pattinson, G Fatania, A J Strong, R B Myers, C Lazaridis, C M Jermaine, C S Robertson, C G Rusin, J Hofmeijer, L Sondag, M C Tjepkema-Cloostermans, A Beishuizen, F H Bosch, M J A M van Putten, L Carteron, C Patet, D Solari, M Oddo, M A Ali, C Dias, R Almeida, A Vaz-Ferreira, J Silva, E Monteiro, A Cerejo, A P Rocha, A A Elsayed, A M Abougabal, B N Beshey, K M Alzahaby, S Pozzebon, A Blandino Ortiz, S Cristallini, O Lheureux, A Brasseur, J L Vincent, J Creteur, F S Taccone, M Hravnak, K Yousef, Y Chang, E Crago, R M Friedlander, S A Abdelmonem, S A Tahon, T A Helmy, H S Meligy, F Puig, I Dunn-Siegrist, J Pugin, S Gupta, D Govil, S Srinivasan, S J Patel, J K N, A Gupta, D S Tomar, M Shafi, R Harne, D P Arora, N Talwar, S Mazumdar, E E Papakrivou, D Makris, E Manoulakas, B Tsolaki, B Karadodas, E Zakynthinos, I Palacios Garcia, A Diaz Martin, V Sanchez Encinares, M Pachón Ibañez, J Garnacho Montero, G Labrador, T Cebrero Cangueiro, V Poulose, J Koh, J W Kam, H Yeter, A Kara, O Aktepe, A Topeli, I Tsolakoglou, G Intas, P Stergiannis, A A Kolaros, E Chalari, E Athanasiadou, A Martika, G Fildisis, V Faivre, C Mengelle, B Favier, D Payen, A Poppe, M S Winkler, E Mudersbach, J Schreiber, M L Wruck, E Schwedhelm, S Kluge, C Zöllner, T Tavladaki, A M Spanaki, H Dimitriou, E Kondili, C Choulaki, E Meleti, D Kafetzopoulos, D Georgopoulos, G Briassoulis, A García-de la Torre, M V de la Torre-Prados, T Tsvetanova-Spasova, P Nuevo-Ortega, C Rueda-Molina, A Fernández-Porcel, E Camara-Sola, L Salido-Díaz, A García-Alcántara, T Tavladaki, A M Spanaki, H Dimitriou, E Kondili, C Choulaki, D E Meleti, D Kafetzopoulos, D Georgopoulos, G Briassoulis, B Suberviola, J Riera, L Rellan, M Sanchez, J C Robles, E Lopez, R Vicente, E Miñambres, M Santibañez, M Le Guen, J Moore, N Mason, M Windpassinger, O Plattner, E Mascha, D I Sessler, Outcomes Research, U Melia, J Fontanet, J P van den Berg, M M R F Struys, H E M Vereecke, E W Jensen, P J T Rood, F van de Schoor, K van Tertholen, P Pickkers, M van den Boogaard, Z J Beardow, H Redhead, K Paramasivam, T Numan, M van den Boogaard, A M Kamper, P Rood, L M Peelen, P M Zeman, A J Slooter, C E van Ewijk, G E Jacobs, A R J Girbes, S N Myatra, M M Harish, N R Prabu, S Siddiqui, A P Kulkarni, J V Divatia, L D Murbach, M A Leite, E F Osaku, C R L M Costa, M Pelenz, N M Neitzke, M M Moraes, J L Jaskowiak, M M M Silva, R S Zaponi, L R L Abentroth, S M Ogasawara, A C Jorge, P A D Duarte, N Hernández-Sánchez, L A Sánchez-Hurtado, F J García-Guillen, S A Ñamendys-Silva, B Maghsoudi, M Emami, M B Khosravi, F Zand, H R Tabatabaie, M Masjedi, G Sabetiyan, A Mokri, J Troubleyn, M Diltoer, R Jacobs, D N Nguyen, E De Waele, J De Regt, P M Honoré, V Van Gorp, H D Spapen, R S Contreras, N D 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Johansson, A Perner, I W Soliman, D W de Lange, D van Dijk, J J M van Delden, O L Cremer, A J C Slooter, L M Peelen, D McWilliams, C Snelson, A Das Neves, C I Loudet, M Busico, D Vazquez, D Villalba, M Veronesi, A Lischinsky, F J L López, L Benito Mori, G Plotnikow, A Díaz, S Giannasi, R Hernandez, L Krzisnik, C Cecotti, L Viola, R Lopez, J P Sottile, G Benavent, E Estenssoro, C M Chen, C C Lai, K C Cheng, W Chou, K S Chan, L E Roeker, C M Horkan, F K Gibbons, K B Christopher, P J M Weijs, K M Mogensen, J D Rawn, M K Robinson, K B Christopher, Z Tang, C Qiu, B Ouyang, C Cai, X Guan, T Regueira, L Cea, S Juan Carlos, B Elisa, C Puebla, A Vargas, M K Poulsen, L P Thomsen, S Kjærgaard, S E Rees, D S Karbing, T Wollersheim, S Frank, M C Müller, N M Carbon, V Skrypnikov, P A Pickerodt, R Falk, A Mahlau, S Weber-Carstens, A Lee, R Inglis, R Morgan, G Barker, K Kamata, T Abe, D Saitoh, Y Tokuda, R S Green, M B Butler, M Erdogan, H Tae Hwa, L Jae Gil, R Hernández Vaquero, E Rodriguez-Ruiz, A Lopez Lago, J L Garcia Allut, A Estany Gestal, M A Garcia Gonzalez, D O Thomas-Rüddel, D Schwarzkopf, C Fleischmann, K Reinhart, S Suwanpasu, Y Sattayasomboon, N M Filgueiras Filho, J C A Oliveira, C S Ballalai, C V De Lucia, G P Araponga, L N Veiga, C S Silva, M E Garrido, B B Ramos, E F Ricaldi, S S Gomes, L Gemmell, A MacKay, C Wright, R I Docking, P Doherty, E Black, P Stenhouse, M P Plummer, M E Finnis, L K Phillips, P Kar, S Bihari, V Biradar, S Moodie, M Horowitz, J E Shaw, A M Deane, T Yatabe, S Inoue, M Sakaguchi, M Egi, Y Ali Abdelhamid, M P Plummer, M E Finnis, L K Phillips, P Kar, S Bihari, V Biradar, S Moodie, M Horowitz, J E Shaw, A M Deane, M Hokka, M Egi, S Mizobuchi, P Kar, M Plummer, Y Ali Abdelhamid, E Giersch, M Summers, S Hatzinikolas, S Heller, M Chapman, K Jones, M Horowitz, A Deane, R Schweizer, M Jacquet-Lagreze, P Portran, S Junot, B Allaouchiche, J L Fellahi, P Guerci, B Ergin, A Kapucu, C Ince, L Cioccari, N Luethi, M Crisman, R Bellomo, J Mårtensson, C 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Sakamoto, S Inoue, K C Yamada, H Koami, T Miike, F Nagashima, T Iwamura, A Boscolo, V Lucchetta, E Piasentini, D Bertini, L Manesso, L Spiezia, P Simioni, C Ori, R B Souza, A M Martins, A M A Liberatore, Y R Kang, M N Nakamae, J C F Vieira, I H J Koh, K Hanslin, F Wilske, P Skorup, J Sjölin, M Lipcsey, W Jin Long, C Er Zhen, A Vakalos, V Avramidis, S H Wu, L J Shyu, C H Li, C H Yu, H C Chen, C H Wang, K H Lin, Z E Aray, C F Gómez, A P Tejero, D D Monge, V M Losada, C M Tarancón, S D Cortés, A M Gutiérrez, T P Álvarez, A Rouze, K Jaffal, S Six, K Stolz, V Cattoen, S Nseir, J M Arnal, M Saoli, D Novotni, A Garnero, T Becher, V Buchholz, D Schädler, I Frerichs, N Weiler, N Eronia, T Mauri, S Gatti, E Maffezzini, A Bronco, L Alban, T Sasso, C Marenghi, G Grasselli, A Pesenti, G Bellani, A Al-Fares, L Del Sorbo, S Anwar, F Facchin, S Azad, R Zamel, N Ferguson, M Cypel, S Keshavjee, E Fan, E Durlinger, A Spoelstra-de Man, B Smit, H J de Grooth, A Girbes, H Oudemans-van Straaten, Y Smulders, M A Alfaro, F Parrilla, A Meli, M Pellegrini, N Rodriguez, J M Goyeneche, I Morán, H Aguirre, J Mancebo, S J H Heines, U Strauch, D C J J Bergmans, P Blankman, A Shono, D Hasan, D Gommers, W Y Chung, K S Lee, Y J Jung, J H Park, S S Sheen, K J Park, R Worral, S Denham, P Isherwood, S E Rees, S Larraza, N Dey, S Spadaro, J B Brohus, R W Winding, C A Volta, D S Karbing, F Ampatzidou, A Vlachou, G Kehagioglou, T Karaiskos, A Madesis, C Mauromanolis, N Michail, G Drossos, N Saraj, S Rijkenberg, H M Feijen, H Endeman, A A J Donnelly, E Morgan, H Garrard, H Buckley, L Russell, N Haase, A Perner, C Goh, K Mouyis, C L N Woodward, J Halliday, G B Encina, J Ros, L Lagunes, J Tabernero, F Bosch, J Rello, D García Huertas, F Manzano, E Morente-Constantin, B Rivera-Ginés, M Colmenero-Ruiz, A Naharro Abellán, L Pérez Pérez, A Pérez Lucendo, P Matía Almudévar, J Palamidessi Domínguez, P Rodríguez Villamizar, J García Sanz, I Fernandez Simon, B Lobo Valbuena, S Alcantara Carmona, M Pais, S Ramalingam, C Díaz, L Fox, M Santafe, P Barba, M García, S Leal, M Pérez, M L Pérez Pérez, A Naharro Abellán, A Pérez Lucendo, P Matia Almudevar, J Palamidessi Domínguez, P Rodríguez Villamizar, J Veganzones, I Fernandez Simón, B Lobo Valbuena, N Martínez, S Alcántara Carmona, I Moors, D Mokart, F Pène, J Lambert, A Kouatchet, J Mayaux, F Vincent, M Nyunga, F Bruneel, L Laisne, A Rabbat, C Lebert, P Perez, M Chaize, A Renault, A P Meert, R Hamidfar, M Jourdain, M Darmon, B Schlemmer, S Chevret, V Lemiale, E Azoulay, D Benoit, D Martins-Branco, M Sousa, S Marum, M J Bouw, G Galstyan, P Makarova, E Parovichnikova, L Kuzmina, V Troitskaya, N Drize, E Gemdzhian, V Savchenko, H C Chao, E Kılıc, B Demiriz, M L Uygur, M Sürücü, K Cınar, A E Yıldırım, K Kiss, B Köves, V Csernus, Z Molnár, A Ntantana, D Matamis, S Savvidou, M Giannakou, M Gouva, G Nakos, V Koulouras, S Gaffney, E Black, R Docking, C Judge, T Drew, H Misran, R Munshi, L McGovern, M Coyle, L Dunne, E Deasy, P Lavin, A Fahy, D M Darcy, M Donnelly, N H Ismail, T Hall, K Wykes, J Jack, W C Ngu, P Morgan, J Ruiz-Ramos, P Ramirez, M Gordon, E Villarreal, J Frasquet, J L Poveda-Andrés, A Castellanos, C E Ijssennagger, S Ten Hoorn, A van Wijk, J M van den Broek, P R Tuinman, A M Elmenshawy, B D Hammond, G Gibbon, T Belcham, K Burton, L U Taniguchi, F J S Ramos, A K Momma, A P R Martins-Filho, J J Bartocci, M F D Lopes, M H Sad, C M Rodrigues, E M C Pires, J M Vieira, M A Leite, L D Murbach, E F Osaku, J Barreto, S T Duarte, S Taba, D Miglioranza, D P Gund, C F Lordani, C R L M Costa, S M Ogasawara, A C Jorge, P A D Duarte, S Spadaro, M Capuzzo, F Dalla Corte, S Terranova, G Scaramuzzo, A Fogagnolo, S Bertacchini, A Bellonzi, R Ragazzi, C A Volta, C Cruz, A Nunes, F Seabra Pereira, I Aragão, A F Cardoso, C Santos, M J Malheiro, H Castro, T Cardoso, J Paratz, J Kenardy, T Comans, F Coyer, P Thomas, R Boots, N Pereira, A Vilas-Boas, E Gomes, C Dias, J Torres, D Carvalho, E Molinos, C Vales, R Araújo, C Cruz, A Nunes, F Seabra Pereira, A F Cardoso, C Santos, M J Malheiro, H Castro, T Cardoso, L Karnatovskaia, K Philbrick, G Ognjen, M Clark, R Molina Montero, J Luján Varas, L Alcázar Sánchez-Elvira, C Pintado Delgado, P Villa Díaz, B Llorente Ruiz, A Pardo Guerrero, J A Cambronero Galache, R Jiménez, S Rebollo, O Alejandro, A Fernández, S Moreno, L Herrera, A Ojados, M Galindo, J Murcia, M Contreras, S Sánchez-Argente, Y Bonilla, M D Rodríguez, J M Allegue, Ö Cakin, H Parlak, H Kirca, F Mutlu, B Aydınlı, M Cengiz, A Ramazanoglu, E-J Jung, S-Y Oh, H Lee, N M Filgueiras Filho, E F Ricaldi, S S Gomes, B B Ramos, C V De Lucia, C S Ballalai, J C A Oliveira, G P Araponga, L N Veiga, C S Silva, M E Garrido, J Cebrián Domenech, A Pinos Montalvo, T Ciges Chornet, P Concha Martinez, M Piñol Ribas, R Gimeno Costa, A Castellanos Ortega, C Forbes, H Prescott, A Lal, F A Khan, E G Dela Pena, J S Dizon, P P P Perez, C M J Wong, M Muñoz Garach, O Moreno Romero, R Ramirez Puerta, F Acosta Diaz, A M Perez Bailon, A Carranza Pinel, L Peñas Maldonado, M S Kalaiselvan, R L Siva Kumar, M K Renuka, A S Arun Kumar, S De Rosa, F Ferrari, S Carboni Checcacci, A Rigobello, M Joannidis, F Politi, A Pellizzari, R Bonato, A Fernandez-Carmona, I Macias-Guarasa, R Gutierrez-Rodriguez, P Martinez-Lopez, M A Diaz-Castellanos, A Fernandez-Carmona, M Arias-Diaz, E Aguilar-Alonso, I Macias-Guarasa, P Martinez-Lopez, M A Diaz-Castellanos, R N Nikandish, V Artemenko, A Budnyuk, G Li Bassi, T Senussi, F Idone, E Aguilera Xiol, C Travierso, C Chiurazzi, A Motos, R Amaro, Y Hua, L Fernández-Barat, O T Ranzani, Q Bobi, M Rigol, A Torres, A Youn, J Gyung Hwang, M Muñoz Garach, O Moreno Romero, M E Yuste Ossorio, F Acosta Diaz, A M Perez Bailon, A Carranza Pinel, L Peñas Maldonado, C Teixeira, H Figueira, R Oliveira, A Mota, I Aragão, O Kamp, O Cruciger, M Aach, C Kaczmarek, C Waydhas, T A Schildhauer, U Hamsen, M Camprubí-Rimblas, L Chimenti, R Guillamat-Prats, T Lebouvier, J Bringué, J Tijero, M N Gómez, L Blanch, A Artigas, G Tagliabue, M Ji, J V Suneby Jagers, P A Easton, R B Souza, A M A Liberatore, A M C R P F Martins, J C F Vieira, Y R Kang, M N Nakamae, I H J Koh, J Y Hong, M H Shin, M S Park, A Pomprapa, P A Pickerodt, M B T Hofferberth, M Russ, W Braun, M Walter, R Francis, B Lachmann, S Leonhardt, I H J Koh, R B Souza, A M C R P F Martins, J C F Vieira, A M A Liberatore, A Landaverde-López, N A Canedo-Castillo, A Esquivel-Chávez, P C Arvizu-Tachiquín, L A Sánchez-Hurtado, J A Baltazar-Torres, V Cardoso, A Krystopchuk, S Castro, L Melão, S Firmino, A Marreiros, C Granja, S Almaziad, A Kubbara, W Barnett, R Nakity, W Alamoudi, R Altook, T Tarazi, M Fida, F Safi, R Assaly, A Santini, M Milesi, T Maraffi, P Pugni, D T Andreis, M Cavenago, L Gattinoni, A Protti, G Perchiazzi, J B Borges, S Bayat, L Porra, L Broche, M Pellegrini, G Scaramuzzo, G Hedenstierna, A Larsson, M Pellegrini, G Hedenstierna, A Roneus, M Segelsjö, M C Vestito, A Larsson, G Perchiazzi, E Gremo, A Nyberg, M Castegren, A Pikwer, T Yoshida, D Engelberts, G Otulakowski, B Katira, M Post, N D Ferguson, L Brochard, M B P Amato, B P Kavanagh, N Koch, W Huber, J Hoellthaler, S Mair, V Phillip, R M Schmid, A Beitz, V Baladrón, F J Redondo Calvo, D Padilla, P Villarejo, R Villazala, A S Yuste, N Bejarano, R J Steenstra, H Banierink, J Hof, I C van der Horst, M W Nijsten, M Hoekstra, K Roedl, F Sterz, T Horvatits, K Horvatits, A Drolz, H Herkner, V Fuhrmann, M Kott, K Zitta, B Brandt, C Schildhauer, G Elke, L Hummitzsch, I Frerichs, N Weiler, M Albrecht, L Rey González, D Cabestrero Alonso, A Blandino Ortiz, R de Pablo Sánchez, J Higuera Lucas, K Roedl, F Sterz, A Drolz, K Horvatits, T Horvatits, H Herkner, V Fuhrmann, T Horvatits, A Drolz, K Roedl, K Rutter, A Ferlitsch, G Fauler, M Trauner, V Fuhrmann, T Horvatits, S Pischke, L Fischer, F Thaiss, M Koch, K Bangert, V Fuhrmann, S Kluge, A W Lohse, B Nashan, M Sterneck, S Faenza, A Siniscalchi, E Pierucci, E Mancini, D Ricci, C Gemelli, A Cuoghi, S Magnani, M Atti, F Sotos, J Cánovas, A López, A Burruezo, D Torres, M E Herrera-Gutierrez, J Barrueco-Francioni, D Arias-Verdú, R Lozano-Saez, G Quesada-Garcia, G Seller-Pérez, A Figueiredo, Y Anzola, R Pereira, L Bento, D Arias-Verdú, M Lai, M Deiana, J Barrueco-Francioni, M E Herrera-Gutierrez, G Seller-Perez, K Vardas, S Ilia, A Sertedaki, E Charmadari, C A Stratakis, E Briassouli, D Goukos, K Psarra, E Botoula, S Tsagarakis, E Mageira, C Routsi, S Nanas, G Briassoulis, A Boscolo, D Bertini, E Campello, V Lucchetta, E Piasentini, C M Radu, L Manesso, P Simioni, C Ori, H Su, Y M Lam, K Willis, V Pullar, R P Hubner, J L Tsang, L García de Guadiana-Romualdo, S Rebollo-Acebes, P Esteban-Torrella, R Jiménez-Sánchez, E Jiménez-Santos, A Ortín-Freire, A Hernando-Holgado, M D Albaladejo-Otón, L Coelho, L Rabello, J Salluh, I Martin-Loeches, A Rodriguez, S Nseir, P Póvoa, E Varis, V Pettilä, M Poukkanen, S Jacob, S Karlsson, A Perner, J Takala, E Wilkman, O H M Lundberg, L Bergenzaun, J Rydén, M Rosenqvist, O Melander, M S Chew, E Rodriguez-Ruiz, R Hernández Vaquero, A Lopez Lago, J L Garcia Allut, A Estany Gestal, M A Garcia Gonzalez, Y Kishihara, H Yasuda, S Rebollo, L García de Guadiana-Romualdo, R Jimenez, P Esteban Torrella, A Fernandez, S Sanchez, A Ortin, G Li Bassi, R Guillamat Prats, A Artigas, E Aguilera, D Marti, O T Ranzani, M Rigol, L Fernandez, M Ferrer, I Martin-Loeches, A Torres, V S Lanziotti, P Póvoa, L Pulcheri, M O Ribeiro, A P Barbosa, J R Lapa E Silva, M Soares, J I F Salluh, I Palacios Garcia, A Diaz Martin, M Gil Marqués, A Puppo Moreno, A Gutierrez Pizarraya, J Pachón Diaz, M Pachón Ibañez, Y Smani, M Mc Connell, L A Zhang, R S Parker, I Banerjee, G Clermont, E Norberg, J Oras, A Cuisinier, C Maufrais, J F Payen, S Nottin, G Walther, P Bouzat, S Arib, F Bilotta, R Badenes, F Rubulotta, S Mirek, I A Crippa, B Monfort, E Stazi, A Lozano Roig, J Creteur, F S Taccone, S Magnoni, M Marando, S Pifferi, V Conte, F Ortolano, M Carbonara, G Bertani, E Scola, M Cadioli, F Triulzi, A Colombo, N Stocchetti, H B Rotzel, A Serrano Lázaro, D Aguillón Prada, M Rodriguez Guimillo, C Sanchís Piqueras, J Romero Guia, M García Simon, A Mesejo Arizmendi, A Carratalá, S El Maraghi, A Yehia, M Bakry, A Shoman, F N Backes, M M Bianchin, S R R Vieira, A de Souza, A N Backes, C Klein, M S Kalaiselvan, M K Renuka, A S Arunkumar, A Lozano, O Lheureux, R Badenes, J L Vincent, J Creteur, F S Taccone, C Gallaher, S Cattlin, S Gordon, J Picard, V Fontana, O Bond, L Nobile, J L Vincent, J Creteur, F S Taccone, S Mrozek, L Delamarre, F Capilla, T Al-Saati, O Fourcade, T Geeraerts, A M Dominguez-Berrot, M Gonzalez-Vaquero, M E Vallejo-Pascual, D Gupta, B D Ivory, M Chopra, J McCarthy, C L Felderhof, C MacNeil, F Rubulotta, P Waldauf, M Maggiorini, F Duska, R R L Fumis, J M Vieira Junior, G Amarante, A Skorko, S Sanders, J Aron, R J Kroll, C Redfearn, P Krishnan, J E Khalil, F Kovari, N Kongpolprom, V Gulia, E Lourenço, L Melão, C Duro, G Baptista, A Alves, B Arminda, M Rodrigues, A Marreiros, C Granja, J Hayward, F Baldwin, R Gray, P A Katinakis, M Stijf, M Ten Kleij, M Jansen-Frederiks, R Broek, M de Bruijne, P E Spronk, K Sinha, M Luney, K Palmer, L Keating, M Abu-Habsa, R Bahl, N Baskaralingam, A Ahmad, L Kanapeckaite, P Bhatti, S Glace, S Jeyabraba, H F Lewis, A Kostopoulos, M Raja, A West, A Ely, L M Turkoglu, P Zolfaghari, J P Baptista, M P Marques, P Martins, J Pimentel, D Gupta, Y C Su, S Villacres, M E Stone, A Parsikia, S Medar, K P O'Dea, J Porter, N Tirlapur, J M Jonathan, S Singh, M Takata, M Abu-Habsa, A Ahmad, E McWhirter, R Lyon, M L Hariz, E Azmi, J Alkhan, S Honeybul, V Movsisyan, S Petrikov, Z Marutyan, I Aliev, A Evdokimov, E Antonucci, T Merz, C Hartmann, P Pelosi, E Calzia, P Radermacher, B Nußbaum, C Hartmann, M Huber-Lang, M Gröger, P Radermacher, B Nußbaum, B Nußbaum, E Antonucci, E Calzia, P Pelosi, P Radermacher, C Hartmann, E Svoren-Jabalera, E E Davenport, P Humburg, J Knight, C J Hinds, I J Jun, W J Kim, E H Lee, G Besch, A Perrotti, M Puyraveau, L Carteron, M Baltres, E Samain, S Chocron, S Pili-Floury, E P Plata-Menchaca, J Sabater-Riera, M Estruch, E Boza, F Sbraga, J Toscana-Fernández, E Bruguera-Pellicer, J Ordoñez-Llanos, X L Pérez-Fernández, P Cavaleiro, A Tralhão, M Arrigo, J-P Lopes, M Lebrun, B Cholley, J L PerezVela, H MarinMateos, J J Jimenez Rivera, M A Alcala Llorente, B Gonzalez De Marcos, F J Gonzalez Fernandez, C Garcia Laborda, D Fernandez Zamora, J C Lopez Delgado, C Imperiali, D Berbel-Franco, M Dastis, G Moreno-Gonzalez, J Perez-Sanchez, I Romera-Peregrina, R Abellan-Lencina, A Martinez-Pascual, V Fuentes-Mila, M Gonzalez-Romero, J Górka, K Górka, T Iwaniec, M Frołow, K Polok, J Fronczek, M Kózka, J Musiał, W Szczeklik, A González Pérez, P Florez Ordoñez, A Giribet, M A Alonso Cuervo, R Alonso Cuervo, M A Rodriguez Esteban, L Iglesias Fraile, C Ponte Mittelbrum, G Muñiz Albaiceta, F Ampatzidou, M Sileli, G Kehagioglou, A Madesis, T Karaiskos, C Moursia, H Maleoglou, K Leleki, G Drossos, Z Uz, Y Ince, R Papatella, E Bulent, P Guerci, C Ince, B De Mol, V Vicka, D Gineityte, D Ringaitiene, I Norkiene, J Sipylaite, C Möller, C Fleischmann, D O Thomas-Rueddel, V Vlasakov, B Rochwerg, P Theurer, L Gattinoni, K Reinhart, C S Hartog, A González Pérez, J Zanabili Al Sibai, P Martinez Camblor, P Alvarez Fernandez, J M García Gala, J Silba Guisasola, G Muñiz Albaiceta, T Tamura, T Yatabe, I Miyajima, K Yamashita, M Yokoyama, F Ampatzidou, G Kehagioglou, E Dalampini, M Nastou, A Baddour, A Ignatiadis, T Asteri, G Drossos, K E Hathorn, S W Purtle, C M Horkan, F K Gibbons, K B Christopher, M V Viana, T A Tonietto, L A Gross, V L Costa, A L J Tavares, B O Lisboa, R B Moraes, S R Vieira, L V Viana, M J Azevedo, G D Ceniccola, R S F Pequeno, T P Holanda, V S Mendonça, W M C Araújo, L S F Carvalho, E Segaran, L Vickers, K Brinchmann, I Wignall, F Rubulotta, I De Brito-Ashurst, R Del Olmo, M J Esteban, C Vaquerizo, R Carreño, V Gálvez, G Kaminsky, B Nieto, M Fuentes, M A De la Torre, E Torres, A Alonso, C Velayos, T Saldaña, A Escribá, J Grip, R Kölegård, P Sundblad, O Rooyackers, Ben Naser, F Jaziri, A Ben Jazia, M Barghouth, O Hentati, W Skouri, M El Euch, M Mahfoudhi, S Turki, K Ben Abdelghni, Ben Abdallah, B N M Maha, J Cánovas, F Sotos, A López, M Lorente, A Burruezo, D Torres, K Polok, A Włudarczyk, J Górka, A Hałek, J Musiał, W Szczeklik, A Ben Jazia, F Jaziri, M Bargouth, M Bennasr, S Turki, K Ben Abdelghani, T Ben Abdallah, H J de Grooth, I L Geenen, J J Parienti, H M Oudemans-van Straaten, H P Shum, H S King, K C Chan, W W Yan, J Gonzalez Londoño, C Lorencio Cardenas, M Morales Pedrosa, C Murcia Gubianas, C Fuster Bertolin, N Vila Batllori, J M Sirvent, K Wykes, J Jack, P Morgan, A Mukhopadhyay, H Y Chan, Y Kowitlawakul, D Remani, C S F Leong, C J Henry, Z A Puthucheary, N Mendsaikhan, T Begzjav, G Lundeg, M Dünser, E D Valenzuela Espinoza, S P Welsh, M F Motta, E Guerra, M C L Zerpa, F Zechner, M Furche, F Berdaguer, P N Rubatto Birri, A Risso-Vazquez, A Dubin, F D Masevicius, D Greaney, A Magee, G Fitzpatrick, R G Lugo-Cob, L A Sánchez-Hurtado, P C Arvizu-Tachiquín, B C Tejeda-Huezo, A A Cano-Oviedo, J A Baltazar-Torres, M S Aydogan, T Togal, A Taha, H Z Chai, C Kam, S S Yang Razali, V Sivasamy, L Y Kuan, V Poulose, M A Lopez Morales, S Castro, T Pires, L Melão, A Krystopchuk, I Pereira, C Granja, L U Taniguchi, E M C Pires, J M Vieira, L C P Azevedo
No abstract text is available yet for this article.
September 2016: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27609187/alpha-2-agonists-for-sedation-in-mechanically-ventilated-neurocritical-care-patients-a-systematic-review-protocol
#3
Alexandre Tran, Henrietta Blinder, Brian Hutton, Shane English
BACKGROUND: Sedation is an important consideration in the care of the neurocritically ill patient. It provides anxiety and relief, facilitates procedures and nursing tasks, and minimizes intolerance of mechanical ventilation. Alpha-2 agonists such as dexmedetomidine and clonidine have been shown to be an effective alternative in the general critical care population by reducing duration of mechanical ventilation and length of stay in the intensive care unit (ICU), as compared to traditional sedative agents such as propofol or benzodiazepines...
September 8, 2016: Systematic Reviews
https://www.readbyqxmd.com/read/27397065/targeted-temperature-management-in-spontaneous-intracerebral-hemorrhage-a-systematic-review
#4
Marlene Fischer, Alois Schiefecker, Peter Lackner, Raimund Helbok, Ronny Beer, Bettina Pfausler, Erich Schmutzhard, Gregor Broessner
Fever is common in neurocritical care patients and is associated with poor outcome. Targeted temperature management (TTM), i.e. therapeutic hypothermia or controlled normothermia, after acute brain injury has been studied as a neuroprotectant for several decades. In contrast to pharmacological agents with specific targets TTM affects multiple pathophysiological mechanisms and is primarily thought to attenuate secondary brain injury. Most promising results have been obtained from experimental studies on cerebral ischemia or traumatic brain injury showing beneficial effects of hypothermia on structural and functional outcome...
July 3, 2016: Current Drug Targets
https://www.readbyqxmd.com/read/27244574/the-effectiveness-and-safety-of-pharmacological-prophylaxis-against-venous-thromboembolism-in-patients-with-moderate-to-severe-traumatic-brain-injury-a-systematic-review-and-meta-analysis
#5
Luis Albeiro Mesa Galan, Juan José Egea-Guerrero, Manuel Quintana Diaz, Angel Vilches-Arenas
BACKGROUND: Venous thromboembolism (VTE) is a common, potentially fatal complication after traumatic brain injury (TBI). The objective was to evaluate the effectiveness and safety of pharmacologic VTE prophylaxis in moderate to severe TBI patients, and its use in hospitals. DATA SOURCES: A systematic review of the literature was conducted using Medline, Embase, Central database, Google scholar, and the SciELO from 1966 to 2014. STUDY SELECTION & DATA EXTRACTION: All studies providing information on the following variables-use of VTE prophylaxis (both pharmacological and nonpharmacological), initiation of treatment, application of specific protocols, rates of VTE and hemorrhagic progression of the traumatic brain injury on computed tomographic scan-were included...
September 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27046655/role-of-dexmedetomidine-for-sedation-in-neurocritical-care-patients-a-qualitative-systematic-review-and-meta-analysis-of-current-evidence
#6
Georgia G Tsaousi, Massimo Lamperti, Federico Bilotta
INTRODUCTION: This systematic review appraises the clinical evidence on efficacy and safety of dexmedetomidine (DEX), as a sole sedative or as sedative adjunct in adult neurocritical care (NCC) patients. MATERIALS AND METHODS: A database search was conducted to identify randomized clinical trials and observational studies reporting the use of DEX alone or as adjunct for sedation in NCC setting. The primary outcome was the occurrence of hemodynamic changes, whereas the secondary outcomes were sedative and analgesic efficacy, quality and time to awakening, and development of adverse events...
May 2016: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/26879572/decompressive-craniectomy-in-neurocritical-care
#7
REVIEW
Jia-Wei Wang, Jin-Ping Li, Ying-Lun Song, Ke Tan, Yu Wang, Tao Li, Peng Guo, Xiong Li, Yan Wang, Qi-Huang Zhao
Recently, several randomized controlled trials (RCT) investigating the effectiveness of decompressive craniectomy in the context of neurocritical illnesses have been completed. Thus, a meta-analysis to update the current evidence regarding the effects of decompressive craniectomy is necessary. We searched PUBMED, EMBASE and the Cochrane Central Register of Controlled Trials. Other sources, including internet-based clinical trial registries and grey literature, were also searched. After searching the literature, two investigators independently performed literature screening, assessing the quality of the included trials and extracting the data...
May 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/26863153/pediatric-neurocritical-care-in-the-21st-century-from-empiricism-to-evidence
#8
Mark S Wainwright, Gregory Hansen, Juan Piantino
PURPOSE OF REVIEW: Approximately one in five children admitted to a pediatric ICU have a new central nervous system injury or a neurological complication of their critical illness. The spectrum of neurologic insults in children is diverse and clinical practice is largely empirical, as few randomized, controlled trials have been reported. This lack of data poses a substantial challenge to the practice of pediatric neurocritical care (PNCC). PNCC has emerged as a novel subspecialty, and its presence is expanding within tertiary care centers...
April 2016: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/26844988/informatics-in-neurocritical-care-new-ideas-for-big-data
#9
Marine Flechet, Fabian Güiza Grandas, Geert Meyfroidt
PURPOSE OF REVIEW: Big data is the new hype in business and healthcare. Data storage and processing has become cheap, fast, and easy. Business analysts and scientists are trying to design methods to mine these data for hidden knowledge. Neurocritical care is a field that typically produces large amounts of patient-related data, and these data are increasingly being digitized and stored. This review will try to look beyond the hype, and focus on possible applications in neurointensive care amenable to Big Data research that can potentially improve patient care...
April 2016: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/26763913/early-tracheostomy-in-ventilated-stroke-patients-study-protocol-of-the-international-multicentre-randomized-trial-setpoint2-stroke-related-early-tracheostomy-vs-prolonged-orotracheal-intubation-in-neurocritical-care-trial-2
#10
Silvia Schönenberger, Wolf-Dirk Niesen, Hannah Fuhrer, Colleen Bauza, Christina Klose, Meinhard Kieser, José I Suarez, David B Seder, Julian Bösel
BACKGROUND: Tracheostomy is a common procedure in long-term ventilated critical care patients and frequently necessary in those with severe stroke. The optimal timing for tracheostomy is still unknown, and it is controversial whether early tracheostomy impacts upon functional outcome. METHOD: The Stroke-related Early Tracheostomy vs. Prolonged Orotracheal Intubation in Neurocritical care Trial 2 (SETPOINT2) is a multicentre, prospective, randomized, open-blinded endpoint (PROBE-design) trial...
April 2016: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/26577436/risks-and-benefits-of-stress-ulcer-prophylaxis-in-adult-neurocritical-care-patients-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#11
REVIEW
Bolin Liu, Shujuan Liu, Anan Yin, Javed Siddiqi
INTRODUCTION: Neurocritical care patients are at high risk for stress-related upper gastrointestinal (UGI) bleeding. The aim of this meta-analysis was to evaluate the risks and benefits of stress ulcer prophylaxis (SUP) in this patient group. METHODS: A systematic search of major electronic literature databases was conducted. Eligible studies were randomized controlled trials (RCTs) in which researchers compared the effects of SUP (with proton pump inhibitors or histamine 2 receptor antagonists) with placebo or no prophylaxis in neurocritical care patients...
November 17, 2015: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/26263123/postoperative-care-of-the-neurosurgical-patient
#12
REVIEW
Martin Siegemund, Luzius A Steiner
PURPOSE OF REVIEW: Monitoring and therapy of patients in neurocritical care are areas of intensive research and the current evidence needs further confirmation. RECENT FINDINGS: A consensus statement of the Neurocritical Care Society and the European Society of Intensive Care Medicine provided pragmatic guidance and recommendations for multimodal monitoring in neurocritical care patients. Only a minority of these recommendations have strong evidence. In addition, recent multicenter randomized controlled trials concerning the therapy of subarachnoidal hemorrhage and traumatic brain injury could not show decreased mortality or improved functional neurologic outcome after the interventions...
October 2015: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/25971341/hypoxia-and-outcome-prediction-in-early-stage-coma-project-hope-an-observational-prospective-cohort-study
#13
Alex Lopez-Rolon, Andreas Bender
BACKGROUND: The number of resuscitated cardiac arrest patients suffering from anoxic-ischemic encephalopathy is considerable. However, outcome prediction parameters such as somatosensory evoked potentials need revision because they are based on data predating the implementation of mild therapeutical hypothermia and because data from our own laboratory suggest that they may fail to predict prognosis accurately. The present research project "Hypoxia and Outcome Prediction in Early-Stage Coma" is an ongoing observational prospective cohort study that aims to improve outcome prediction in anoxic coma by limiting the effects of falsely pessimistic predictions at the intensive care unit...
May 15, 2015: BMC Neurology
https://www.readbyqxmd.com/read/25894451/alternative-clinical-trial-design-in-neurocritical-care
#14
REVIEW
Christos Lazaridis, Andrew I R Maas, Michael J Souter, Renee H Martin, Randal M Chesnut, Stacia M DeSantis, Gene Sung, Peter D Leroux, Jose I Suarez
Neurocritical care involves the care of highly complex patients with combinations of physiologic derangements in the brain and in extracranial organs. The level of evidence underpinning treatment recommendations remains low due to a multitude of reasons including an incomplete understanding of the involved physiology; lack of good quality, prospective, standardized data; and the limited success of conventional randomized controlled trials. Comparative effectiveness research can provide alternative perspectives and methods to enhance knowledge and evidence within the field of neurocritical care; these include large international collaborations for generation and maintenance of high quality data, statistical methods that incorporate heterogeneity and individualize outcome prediction, and finally advanced bioinformatics that integrate large amounts of variable-source data into patient-specific phenotypes and trajectories...
June 2015: Neurocritical Care
https://www.readbyqxmd.com/read/25832350/multi-modality-neuro-monitoring-conventional-clinical-trial-design
#15
REVIEW
Alexandros L Georgiadis, Yuko Y Palesch, David Zygun, J Claude Hemphill, Claudia S Robertson, Peter D Leroux, Jose I Suarez
Multi-modal monitoring has become an integral part of neurointensive care. However, our approach is at this time neither standardized nor backed by data from randomized controlled trials. The goal of the second Neurocritical Care Research Conference was to discuss research priorities in multi-modal monitoring, what research tools are available, as well as the latest advances in clinical trial design. This section of the meeting was focused on how such a trial should be designed so as to maximize yield and avoid mistakes of the past...
June 2015: Neurocritical Care
https://www.readbyqxmd.com/read/25619535/decompressive-craniectomy-in-neurocritical-care
#16
Stacy Y Chu, Kevin N Sheth
Decompressive craniectomy (DC) involves the removal of a portion of the skull in the setting of life threatening brain edema or potentially uncontrollable intracranial pressures. Often performed on an emergent basis, evaluation and arrangement for DC should be swift and decisive. However, the evidence base for DC in the wide range of conditions for which it is currently performed is still developing. The procedure is associated with a number of complications and ethical considerations; thus, its place in contemporary practice remains controversial...
February 2015: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/25607336/amantadine-for-patients-with-severe-traumatic-brain-injury-a-critically-appraised-topic
#17
REVIEW
Scott D Spritzer, Carolyn L Kinney, John Condie, Kay E Wellik, Charlene R Hoffman-Snyder, Dean M Wingerchuk, Bart M Demaerschalk
BACKGROUND: Research into traumatic brain injury (TBI) has increased significantly. Diagnostic testing and therapeutics for patients with severe TBI are 2 areas on which there is increasing focus. Amantadine hydrochloride is one treatment considered to have potential therapeutic value in this patient population. OBJECTIVE: The objective was addressed through the development of a structured critically appraised topic. This included a clinical scenario, structured question, literature search strategy, critical appraisal, results, evidence summary, commentary, and bottom-line conclusions...
January 2015: Neurologist
https://www.readbyqxmd.com/read/25366626/perioperative-measures-to-improve-outcome-after-subarachnoid-hemorrhage-revisiting-the-concept-of-secondary-brain-injury
#18
REVIEW
Hans-Jakob Steiger, Thomas Beez, Kerim Beseoglu, Daniel Hänggi, Marcel A Kamp
Progress in the management of aneurysmal subarachnoid hemorrhage (SAH) is reflected most clearly in a continuously decreasing case fatality rate over the last decades. The purpose of the present review is to identify the relevant factors responsible for this progress and to outline future possibilities of improvement. Although data on intracerebral hemorrhage and ischemic stroke are less homogeneous, the respective data suggest that reduction of case fatalities could also be achieved with these types of stroke...
2015: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/25199613/randomized-controlled-trial-of-a-scoring-aid-to-improve-glasgow-coma-scale-scoring-by-emergency-medical-services-providers
#19
RANDOMIZED CONTROLLED TRIAL
Amanda Feldman, Kimberly W Hart, Christopher J Lindsell, Jason T McMullan
STUDY OBJECTIVE: Emergency medical services (EMS) personnel frequently use the Glasgow Coma Scale (GCS) to assess injured and critically ill patients. This study assesses the accuracy of EMS providers' GCS scoring, as well as the improvement in GCS score assessment with the use of a scoring aid. METHODS: This randomized, controlled study was conducted in the emergency department (ED) of an urban academic trauma center. Emergency medical technicians or paramedics who transported a patient to the ED were randomly assigned one of 9 written scenarios, either with or without a GCS scoring aid...
March 2015: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/24740807/the-use-of-targeted-temperature-management-for-elevated-intracranial-pressure
#20
REVIEW
Jesse J Corry
The use of hypothermia for treatment of intracranial hypertension is controversial, despite no other medical therapy demonstrating consistent improvements in morbidity or mortality. Much of this may be the result of negative results from randomized controlled trials. However, the patients selected for these trials may have obscured the results in the populations most likely to benefit. Further, brain injury does not behave uniformly, not even within a diagnosis. Therefore, therapies may have more benefit in some diseases, less in others...
June 2014: Current Neurology and Neuroscience Reports
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