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Alan Brown

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https://www.readbyqxmd.com/read/28530503/comparison-of-self-selected-walking-speeds-and-walking-speed-variability-when-data-are-collected-during-repeated-discrete-trials-and-during-continuous-walking
#1
Marcus J Brown, Laura A Hutchinson, Michael J Rainbow, Kevin J Deluzio, Alan R De Asha
A typical gait analysis data collection consists of a series of discrete trials, where a participant initiates gait, walks through a motion capture volume, and then terminates gait. This is not a normal 'everyday' gait pattern, yet measurements are considered representative of normal walking. However, walking speed, a global descriptor of gait quality that can affect joint kinematics and kinetics, may be different during discrete trials, compared to continuous walking. Therefore, the purpose of this study was to investigate the effect of continuous walking versus discrete trials on walking speed and walking speed variability...
May 22, 2017: Journal of Applied Biomechanics
https://www.readbyqxmd.com/read/28521661/from-the-editors-brief-synopsis
#2
E Sherwood Brown, Alan I Green
No abstract text is available yet for this article.
May 19, 2017: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/28510487/origin-of-the-ttc-values-for-compounds-that-are-genotoxic-and-or-carcinogenic-and-an-approach-for-their-re-evaluation
#3
Alan Boobis, Paul Brown, Mark Timothy David Cronin, James Edwards, Corrado Lodovico Galli, Jay Goodman, Abigail Jacobs, David Kirkland, Mirjam Luijten, Cyril Marsaux, Matthew Martin, Chihae Yang, Heli Miriam Hollnagel
The threshold of toxicological concern (TTC) approach is a resource-effective de minimis method for the safety assessment of chemicals, based on distributional analysis of the results of a large number of toxicological studies. It is being increasingly used to screen and prioritize substances with low exposure for which there is little or no toxicological information. The first step in the approach is the identification of substances that may be DNA-reactive mutagens, to which the lowest TTC value is applied...
May 16, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28503768/the-contribution-of-cardio-metabolic-risk-factors-to-estimated-glomerular-filtration-rate-egfr-decline-in-indigenous-australians-with-and-without-albuminuria-the-egfr-follow-up-study
#4
Elizabeth Barr, Federica Barzi, Jaquelyne T Hughes, George Jerums, Kerin O'Dea, Alex Brown, Elif I Ekinci, Graham Rd Jones, Paul D Lawton, Ashim Sinha, Richard J MacIsaac, Alan Cass, Louise J Maple-Brown
BACKGROUND: Risk factors for estimated glomerular filtration rate (eGFR) decline beyond albuminuria are not fully understood in Indigenous Australians who have a 6-fold risk of end-stage kidney disease. We assessed associations between cardio-metabolic risk factors and eGFR decline according to baseline albuminuria status to identify potential treatment targets. METHODS: The eGFR Follow-up study is a longitudinal cohort of 520 Indigenous Australians. Linear mixed regression was used to estimate associations between baseline cardio-metabolic risk factors and annual Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) eGFR change (ml/min/1...
May 14, 2017: Nephrology
https://www.readbyqxmd.com/read/28502512/metreleptin-therapy-lowers-plasma-angiopoietin-like-protein-3-in-patients-with-generalized-lipodystrophy
#5
Ranganath Muniyappa, Brent S Abel, Asha Asthana, Mary F Walter, Elaine K Cochran, Alan T Remaley, Monica C Skarulis, Phillip Gorden, Rebecca J Brown
BACKGROUND: Reduced triglyceride clearance due to impaired lipoprotein lipase-mediated lipolysis contributes to severe hypertriglyceridemia in lipodystrophy. Angiopoietin-like protein 3 (ANGPTL3) and 4 (ANGPTL4) impair clearance of triglycerides by inhibiting lipoprotein lipase. Whether circulating ANGPTL3/4 levels are altered in lipodystrophy and the effects of leptin replacement on these ANGPTLs are unknown. OBJECTIVE: To examine if ANGPTL3/4 levels are elevated in patients with generalized lipodystrophy and assess the effects of leptin replacement on these ANGPTLs...
March 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28502236/family-presence-in-the-adult-icu-during-bedside-procedures
#6
Marnie Jakab, Alex Z Day, Alan Kraguljac, Maedean Brown, Sangeeta Mehta
PURPOSE: To understand perspectives of family members of adult patients admitted to the medical-surgical intensive care unit (ICU) regarding their presence during procedures. METHODS: Respondents completed a questionnaire about procedures the patient had undergone, their desire to be present, and their experience. Procedures of interest were endotracheal intubation; chest compressions; vascular catheter insertion; and gastric, chest, and rectal tubes. Impact of Events Scale-Revised (IES-R) was completed at the time of questionnaire completion and again 1 month later to evaluate the psychological impact of witnessing a procedure...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28498310/selective-expression-of-flt3-within-the-mouse-hematopoietic-stem-cell-compartment
#7
Ciaran James Mooney, Alan Cunningham, Panagiotis Tsapogas, Kai-Michael Toellner, Geoffrey Brown
The fms-like tyrosine kinase 3 (Flt3) is a cell surface receptor that is expressed by various hematopoietic progenitor cells (HPC) and Flt3-activating mutations are commonly present in acute myeloid and lymphoid leukemias. These findings underscore the importance of Flt3 to steady-state and malignant hematopoiesis. In this study, the expression of Flt3 protein and Flt3 mRNA by single cells within the hematopoietic stem cell (HSC) and HPC bone marrow compartments of C57/BL6 mice was investigated using flow cytometry and the quantitative reverse transcription polymerase chain reaction...
May 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28494224/trauma-case-studies-and-dual-diagnosis-consequences
#8
E Sherwood Brown, Alan I Green
No abstract text is available yet for this article.
April 2017: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/28483404/mycobacteria-specific-cytokine-responses-as-correlates-of-treatment-response-in-active-and-latent-tuberculosis
#9
Vanessa Clifford, Marc Tebruegge, Christel Zufferey, Susie Germano, Ben Forbes, Lucy Cosentino, Emma McBryde, Damon Eisen, Roy Robins-Browne, Alan Street, Justin Denholm, Nigel Curtis
OBJECTIVES: A biomarker indicating successful tuberculosis (TB) therapy would assist in determining appropriate length of treatment. This study aimed to determine changes in mycobacteria-specific antigen-induced cytokine biomarkers in patients receiving therapy for latent or active TB, to identify biomarkers potentially correlating with treatment success. METHODS: A total of 33 adults with active TB and 36 with latent TB were followed longitudinally over therapy...
May 5, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28476736/nccn-guidelines-insights-hepatobiliary-cancers-version-1-2017
#10
Al B Benson, Michael I D'Angelica, Daniel E Abbott, Thomas A Abrams, Steven R Alberts, Daniel Anaya Saenz, Chandrakanth Are, Daniel B Brown, Daniel T Chang, Anne M Covey, William Hawkins, Renuka Iyer, Rojymon Jacob, Andrea Karachristos, R Kate Kelley, Robin Kim, Manisha Palta, James O Park, Vaibhav Sahai, Tracey Schefter, Carl Schmidt, Jason K Sicklick, Gagandeep Singh, Davendra Sohal, Stacey Stein, G Gary Tian, Jean-Nicolas Vauthey, Alan P Venook, Andrew X Zhu, Karin G Hoffmann, Susan Darlow
The NCCN Guidelines for Hepatobiliary Cancers provide treatment recommendations for cancers of the liver, gallbladder, and bile ducts. The NCCN Hepatobiliary Cancers Panel meets at least annually to review comments from reviewers within their institutions, examine relevant new data from publications and abstracts, and reevaluate and update their recommendations. These NCCN Guidelines Insights summarize the panel's discussion and most recent recommendations regarding locoregional therapy for treatment of patients with hepatocellular carcinoma...
May 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28468619/economic-and-quality-of-care-evaluation-of-dialysis-service-models-in-remote-australia-protocol-for-a-mixed-methods-study
#11
Gillian Gorham, Kirsten Howard, Samantha Togni, Paul Lawton, Jaquelyne Hughes, Sandawana William Majoni, Sarah Brown, Sue Barnes, Alan Cass
BACKGROUND: Australia's Northern Territory (NT) has the country's highest incidence and prevalence of kidney disease. Indigenous people from remote areas suffer the heaviest disease burden. Concerns regarding cost and sustainability limit the provision of dialysis treatments in remote areas and most Indigenous people requiring dialysis relocate to urban areas. However, this dislocation of people from their family, community and support networks may prove more costly when the broader health, societal and economic consequences for the individual, family and whole of government are considered...
May 3, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28461589/appropriate-use-criteria-for-ventilation-perfusion-imaging-in-pulmonary-embolism-summary-and-excerpts
#12
Alan D Waxman, Marika Bajc, Michael Brown, Frederic H Fahey, Leonard M Freeman, Linda B Haramati, Peter Julien, Grégoire Le Gal, Brian Neilly, Joseph Rabin, Gabriel Soudry, Victor Tapson, Sam Torbati, Julie Kauffman, Sukhjeet Ahuja, Kevin Donohoe
No abstract text is available yet for this article.
May 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28431249/macrophages-facilitate-electrical-conduction-in-the-heart
#13
Maarten Hulsmans, Sebastian Clauss, Ling Xiao, Aaron D Aguirre, Kevin R King, Alan Hanley, William J Hucker, Eike M Wülfers, Gunnar Seemann, Gabriel Courties, Yoshiko Iwamoto, Yuan Sun, Andrej J Savol, Hendrik B Sager, Kory J Lavine, Gregory A Fishbein, Diane E Capen, Nicolas Da Silva, Lucile Miquerol, Hiroko Wakimoto, Christine E Seidman, Jonathan G Seidman, Ruslan I Sadreyev, Kamila Naxerova, Richard N Mitchell, Dennis Brown, Peter Libby, Ralph Weissleder, Filip K Swirski, Peter Kohl, Claudio Vinegoni, David J Milan, Patrick T Ellinor, Matthias Nahrendorf
Organ-specific functions of tissue-resident macrophages in the steady-state heart are unknown. Here, we show that cardiac macrophages facilitate electrical conduction through the distal atrioventricular node, where conducting cells densely intersperse with elongated macrophages expressing connexin 43. When coupled to spontaneously beating cardiomyocytes via connexin-43-containing gap junctions, cardiac macrophages have a negative resting membrane potential and depolarize in synchrony with cardiomyocytes. Conversely, macrophages render the resting membrane potential of cardiomyocytes more positive and, according to computational modeling, accelerate their repolarization...
April 20, 2017: Cell
https://www.readbyqxmd.com/read/28409557/randomised-controlled-trial-of-silk-therapeutic-garments-for-the-management-of-atopic-eczema-in-children-the-clothes-trial
#14
Kim S Thomas, Lucy E Bradshaw, Tracey H Sach, Fiona Cowdell, Jonathan M Batchelor, Sandra Lawton, Eleanor F Harrison, Rachel H Haines, Amina Ahmed, Taraneh Dean, Nigel P Burrows, Ian Pollock, Hannah K Buckley, Hywel C Williams, Joanne Llewellyn, Clare Crang, Jane D Grundy, Juliet Guiness, Andrew Gribbin, Eileen V Wake, Eleanor J Mitchell, Sara J Brown, Alan A Montgomery
BACKGROUND: Atopic eczema (AE) is a chronic, itchy, inflammatory skin condition that affects the quality of life of children and their families. The role of specialist clothing in the management of AE is poorly understood. OBJECTIVES: To assess the effectiveness and cost-effectiveness of silk garments for the management of AE in children with moderate to severe disease. DESIGN: Parallel-group, observer-blind, randomised controlled trial of 6 months' duration, followed by a 2-month observational period...
April 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28399154/silk-garments-plus-standard-care-compared-with-standard-care-for-treating-eczema-in-children-a-randomised-controlled-observer-blind-pragmatic-trial-clothes-trial
#15
RANDOMIZED CONTROLLED TRIAL
Kim S Thomas, Lucy E Bradshaw, Tracey H Sach, Jonathan M Batchelor, Sandra Lawton, Eleanor F Harrison, Rachel H Haines, Amina Ahmed, Hywel C Williams, Taraneh Dean, Nigel P Burrows, Ian Pollock, Joanne Llewellyn, Clare Crang, Jane D Grundy, Juliet Guiness, Andrew Gribbin, Eleanor J Mitchell, Fiona Cowdell, Sara J Brown, Alan A Montgomery
BACKGROUND: The role of clothing in the management of eczema (also called atopic dermatitis or atopic eczema) is poorly understood. This trial evaluated the effectiveness and cost-effectiveness of silk garments (in addition to standard care) for the management of eczema in children with moderate to severe disease. METHODS AND FINDINGS: This was a parallel-group, randomised, controlled, observer-blind trial. Children aged 1 to 15 y with moderate to severe eczema were recruited from secondary care and the community at five UK medical centres...
April 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28380849/comparative-studies-of-long-wave-laser-induced-breakdown-spectroscopy-emissions-excited-at-1-064-%C3%A2%C2%B5m-and-eye-safe-1-574-%C3%A2%C2%B5m
#16
Ei E Brown, Clayton S-C Yang, Uwe Hommerich, Feng Jin, Sudhir B Trivedi, Alan C Samuels
In this work, comparative long-wave infrared (LWIR) laser-induced breakdown spectroscopy (LIBS) emission studies of two excitation sources: conventional 1.064 μm and eye-safe laser wavelength at 1.574 μm were performed to analyze several widely-used inorganic energetic materials such as ammonium and potassium compounds as well as the organic liquid chemical warfare agent simulant, dimethyl methylphosphate (DMMP). LWIR LIBS emissions generated by both excitation sources were examined using three different detection systems: a single element liquid nitrogen cooled Mercury Cadmium Telluride (MCT) detector, an MCT linear array detection system with multi-channel preamplifiers + integrators, and an MCT linear array detection system with readout integrated circuit...
April 3, 2017: Optics Express
https://www.readbyqxmd.com/read/28374608/long-wave-infrared-lwir-molecular-laser-induced-breakdown-spectroscopy-libs-emissions-of-thin-solid-explosive-powder-films-deposited-on-aluminum-substrates
#17
Clayton S-C Yang, Feng Jin, Sudhir B Trivedi, Ei E Brown, Uwe Hommerich, Ashish Tripathi, Alan C Samuels
Thin solid films made of high nitro (NO2)/nitrate (NO3) content explosives were deposited on sand-blasted aluminum substrates and then studied using a mercury-cadmium-telluride (MCT) linear array detection system that is capable of rapidly capturing a broad spectrum of atomic and molecular laser-induced breakdown spectroscopy (LIBS) emissions in the long-wave infrared region (LWIR; ∼5.6-10 µm). Despite the similarities of their chemical compositions and structures, thin films of three commonly used explosives (RDX, HMX, and PETN) studied in this work can be rapidly identified in the ambient air by their molecular LIBS emission signatures in the LWIR region...
April 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28374589/indazole-6-phenylcyclopropylcarboxylic-acids-as-selective-gpr120-agonists-with-in-vivo-efficacy
#18
William McCoull, Andrew Bailey, Peter Barton, Alan M Birch, Alastair J H Brown, Hayley S Butler, Scott Boyd, Roger J Butlin, Ben Chappell, Paul Clarkson, Shelley Collins, Robert M D Davies, Anne Ertan, Clare D Hammond, Jane L Holmes, Carol Lenaghan, Anita Midha, Pablo Morentin-Gutierrez, Jane E Moore, Piotr Raubo, Graeme Robb
GPR120 agonists have therapeutic potential for the treatment of diabetes, but few selective agonists have been reported. We identified an indazole-6-phenylcyclopropylcarboxylic acid series of GPR120 agonists and conducted SAR studies to optimize GPR120 potency. Furthermore, we identified a (S,S)-cyclopropylcarboxylic acid structural motif which gave selectivity against GPR40. Good oral exposure was obtained with some compounds displaying unexpected high CNS penetration. Increased MDCK efflux was utilized to identify compounds such as 33 with lower CNS penetration, and activity in oral glucose tolerance studies was demonstrated...
April 13, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28372073/fuselage-boundary-layer-refraction-of-fan-tones-radiated-from-an-installed-turbofan-aero-engine
#19
James Gaffney, Alan McAlpine, Michael J Kingan
A distributed source model to predict fan tone noise levels of an installed turbofan aero-engine is extended to include the refraction effects caused by the fuselage boundary layer. The model is a simple representation of an installed turbofan, where fan tones are represented in terms of spinning modes radiated from a semi-infinite circular duct, and the aircraft's fuselage is represented by an infinitely long, rigid cylinder. The distributed source is a disk, formed by integrating infinitesimal volume sources located on the intake duct termination...
March 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28346229/clinical-efficacy-of-gene-modified-stem-cells-in-adenosine-deaminase-deficient-immunodeficiency
#20
Kit L Shaw, Elizabeth Garabedian, Suparna Mishra, Provaboti Barman, Alejandra Davila, Denise Carbonaro, Sally Shupien, Christopher Silvin, Sabine Geiger, Barbara Nowicki, E Monika Smogorzewska, Berkley Brown, Xiaoyan Wang, Satiro de Oliveira, Yeong Choi, Alan Ikeda, Dayna Terrazas, Pei-Yu Fu, Allen Yu, Beatriz Campo Fernandez, Aaron R Cooper, Barbara Engel, Greg Podsakoff, Arumugam Balamurugan, Stacie Anderson, Linda Muul, G Jayashree Jagadeesh, Neena Kapoor, John Tse, Theodore B Moore, Ken Purdy, Radha Rishi, Kathey Mohan, Suzanne Skoda-Smith, David Buchbinder, Roshini S Abraham, Andrew Scharenberg, Otto O Yang, Kenneth Cornetta, David Gjertson, Michael Hershfield, Rob Sokolic, Fabio Candotti, Donald B Kohn
BACKGROUND: Autologous hematopoietic stem cell transplantation (HSCT) of gene-modified cells is an alternative to enzyme replacement therapy (ERT) and allogeneic HSCT that has shown clinical benefit for adenosine deaminase-deficient (ADA-deficient) SCID when combined with reduced intensity conditioning (RIC) and ERT cessation. Clinical safety and therapeutic efficacy were evaluated in a phase II study. METHODS: Ten subjects with confirmed ADA-deficient SCID and no available matched sibling or family donor were enrolled between 2009 and 2012 and received transplantation with autologous hematopoietic CD34+ cells that were modified with the human ADA cDNA (MND-ADA) γ-retroviral vector after conditioning with busulfan (90 mg/m2) and ERT cessation...
May 1, 2017: Journal of Clinical Investigation
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