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Alan Brown

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https://www.readbyqxmd.com/read/28803668/when-does-atopic-dermatitis-warrant-systemic-therapy-recommendations-from-an-expert-panel-of-the-international-eczema-council
#1
Eric L Simpson, Marjolein Bruin-Weller, Carsten Flohr, Michael R Ardern-Jones, Sebastien Barbarot, Mette Deleuran, Thomas Bieber, Christian Vestergaard, Sara J Brown, Michael J Cork, Aaron M Drucker, Lawrence F Eichenfield, Regina Foelster-Holst, Emma Guttman-Yassky, Audrey Nosbaum, Nick J Reynolds, Jonathan I Silverberg, Jochen Schmitt, Marieke M B Seyger, Phyllis I Spuls, Jean-Francois Stalder, John C Su, Roberto Takaoka, Claudia Traidl-Hoffmann, Jacob P Thyssen, Jorien van der Schaft, Andreas Wollenberg, Alan D Irvine, Amy S Paller
BACKGROUND: Although most patients with atopic dermatitis (AD) are effectively managed with topical medication, a significant minority require systemic therapy. Guidelines for decision making about advancement to systemic therapy are lacking. OBJECTIVE: To guide those considering use of systemic therapy in AD and provide a framework for evaluation before making this therapeutic decision with the patient. METHODS: A subgroup of the International Eczema Council determined aspects to consider before prescribing systemic therapy...
August 10, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28802317/aoac-smpr-%C3%A2-2017-002
#2
Susan Audino, Mark Angerhofer, Patricia Atkins, Roger M Brauninger, Paula N Brown, Carolyn Quarles Burdette, Robert Clifford, Jo Marie Cook, Jennifer Donelson, Kevin George, Peter Gibson, Heather L Harris, Thomas Hartlein, George Hodgin, Dorota Inerowicz, Holly E Johnson, George Joseph, Erik J M Konings, Julie A Kowalski, Mary Kay Krogull, Scott Kuzdzal, Robert Lockerman, Cynthia Ludwig, Christina Marrongelli, Katerina Mastovska, Elizabeth Mudge, Gary D Niehaus, Masayuki Nishimura, Melissa Meaney Phillips, Curtis S Phinney, Klaus Reif, Amanda Rigdon, Catherine A Rimmer, Travis Ruthenburg, Aniko M Solyom, Katherine Stenerson, Sidney Sudberg, Alan Sutton, John Szpylka, Jane Weitzel, Paul Winkler, Seth Wong, Joshua Wurzer, Hong You, Scott G Coates
No abstract text is available yet for this article.
July 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28802316/aoac-smpr-%C3%A2-2017-001
#3
Susan Audino, Mark Angerhofer, Patricia Atkins, Roger M Brauninger, Paula N Brown, Carolyn Quarles Burdette, Robert Clifford, Jo Marie Cook, Jennifer Donelson, Kevin George, Peter Gibson, Heather L Harris, Thomas Hartlein, George Hodgin, Dorota Inerowicz, Holly E Johnson, George Joseph, Erik J M Konings, Julie A Kowalski, Mary Kay Krogull, Scott Kuzdzal, Robert Lockerman, Cynthia Ludwig, Christina Marrongelli, Katerina Mastovska, Elizabeth Mudge, Gary D Niehaus, Masayuki Nishimura, Melissa Meaney Phillips, Curtis S Phinney, Klaus Reif, Amanda Rigdon, Catherine A Rimmer, Travis Ruthenburg, Aniko M Solyom, Katherine Stenerson, Sidney Sudberg, Alan Sutton, John Szpylka, Jane Weitzel, Paul Winkler, Seth Wong, Joshua Wurzer, Hong You, Scott G Coates
No abstract text is available yet for this article.
July 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28800182/development-and-preliminary-pilot-evaluation-of-a-brief-tablet-computer-intervention-to-motivate-tobacco-quitline-use-among-smokers-in-substance-use-treatment
#4
Richard A Brown, Jacki Hecht, Erika L Bloom, Haruka Minami, Christopher W Kahler, Ana M Abrantes, Mary E Dubreuil, Alan Gordon, Lawrence H Price, Steven J Ondersma
BACKGROUND AND OBJECTIVES: The majority of individuals in substance use disorder (SUD) treatment also smoke cigarettes; yet, the availability of smoking cessation services in SUD treatment remains limited. In this study, we developed and piloted a brief intervention for smokers in SUD treatment intended to motivate engagement in tobacco quitline treatment (TIME-TQ). METHODS: First, we interviewed 19 smokers in SUD treatment to inform the development of TIME-TQ (Phase 1)...
August 11, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28771220/who-environmental-noise-guidelines-for-the-european-region-a-systematic-review-of-transport-noise-interventions-and-their-impacts-on-health
#5
REVIEW
Alan Lex Brown, Irene van Kamp
This paper describes a systematic review (1980-2014) of evidence on effects of transport noise interventions on human health. The sources are road traffic, railways, and air traffic. Health outcomes include sleep disturbance, annoyance, cognitive impairment of children and cardiovascular diseases. A conceptual framework to classify noise interventions and health effects was developed. Evidence was thinly spread across source types, outcomes, and intervention types. Further, diverse intervention study designs, methods of analyses, exposure levels, and changes in exposure do not allow a meta-analysis of the association between changes in noise level and health outcomes, and risk of bias in most studies was high...
August 3, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28764110/urban-environments-alter-parasite-fauna-weight-and-reproductive-activity-in-the-quenda-isoodon-obesulus
#6
Alison E Hillman, Alan J Lymbery, Aileen D Elliot, R C Andrew Thompson
Some wildlife species are capable of surviving in urbanised environments. However, the implications of urbanisation on wildlife health, and public health regarding zoonoses, are often unknown. Quenda (syn. southern brown bandicoots, Isoodon obesulus) survive in many areas of Perth, Australia, despite urbanisation. This study investigated differences in gastrointestinal and macroscopic ecto-parasitic infections, morphometrics and reproductive status between bushland and urban dwelling quenda. 287 quenda in the greater Perth region were captured and sampled for faeces (to detect gastrointestinal parasites), blood (to detect Toxoplasma gondii antibodies), ectoparasites, and morphometrics...
July 26, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28752049/beta-adrenergic-receptors-are-critical-for-weight-loss-but-not-for-other-metabolic-adaptations-to-the-consumption-of-a-ketogenic-diet-in-male-mice
#7
Nicholas Douris, Bhavna N Desai, Ffolliott M Fisher, Theodore Cisu, Alan J Fowler, Eleen Zarebidaki, Ngoc Ly T Nguyen, Donald A Morgan, Timothy J Bartness, Kamal Rahmouni, Jeffrey S Flier, Eleftheria Maratos-Flier
OBJECTIVE: We have previously shown that the consumption of a low-carbohydrate ketogenic diet (KD) by mice leads to a distinct physiologic state associated with weight loss, increased metabolic rate, and improved insulin sensitivity [1]. Furthermore, we identified fibroblast growth factor 21 (FGF21) as a necessary mediator of the changes, as mice lacking FGF21 fed KD gain rather than lose weight [2]. FGF21 activates the sympathetic nervous system (SNS) [3], which is a key regulator of metabolic rate...
August 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28732519/effectiveness-and-cost-effectiveness-of-daily-all-over-body-application-of-emollient-during-the-first-year-of-life-for-preventing-atopic-eczema-in-high-risk-children-the-beep-trial-protocol-for-a-randomised-controlled-trial
#8
Joanne R Chalmers, Rachel H Haines, Eleanor J Mitchell, Kim S Thomas, Sara J Brown, Matthew Ridd, Sandra Lawton, Eric L Simpson, Michael J Cork, Tracey H Sach, Lucy E Bradshaw, Alan A Montgomery, Robert J Boyle, Hywel C Williams
BACKGROUND: Atopic eczema (AE) is a common skin problem that impairs quality of life and is associated with the development of other atopic diseases including asthma, food allergy and allergic rhinitis. AE treatment is a significant cost burden for health care providers. The purpose of the trial is to investigate whether daily application of emollients for the first year of life can prevent AE developing in high-risk infants (first-degree relative with asthma, AE or allergic rhinitis)...
July 21, 2017: Trials
https://www.readbyqxmd.com/read/28714607/new-insights-into-how-serotonin-selective-reuptake-inhibitors-shape-the-developing-brain
#9
REVIEW
Jay A Gingrich, Heli Malm, Mark S Ansorge, Alan Brown, Andre Sourander, Deepika Suri, Cátia M Teixeira, Martha K Caffrey Cagliostro, Darshini Mahadevia, Myrna M Weissman
Development passes through sensitive periods, during which plasticity allows for genetic and environmental factors to exert indelible influence on the maturation of the organism. In the context of central nervous system (CNS) development, such sensitive periods shape the formation of neuro-circuits that mediate, regulate, and control behavior. This general mechanism allows for development to be guided by both the genetic blueprint, as well as the environmental context. While allowing for adaptation, such sensitive periods are also windows of vulnerability during which external and internal factors can confer risk to brain disorders by derailing adaptive developmental programs...
July 17, 2017: Birth defects research
https://www.readbyqxmd.com/read/28708807/a-systematic-review-of-internet-decision-making-resources-for-patients-considering-surgery-for-ulcerative-colitis
#10
Daniel M Baker, Jack H Marshall, Matthew J Lee, Georgina L Jones, Steven R Brown, Alan J Lobo
BACKGROUND: Guidance from the Royal College of Surgeons advocates patient use of on-line resources to assist in decision making. Our aim was to assess the quality of on-line resources to facilitate decision making for patients considering surgery for ulcerative colitis (UC). METHODS: We undertook a systematic review based on PRISMA guidelines. This was registered on the PROSPERO database (CRD42016047177). We searched Google and repositories using several lay search terms for patient information discussing surgery for UC, published in English...
August 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28699755/co2-reactive-ionic-liquid-surfactants-for-the-control-of-colloidal-morphology
#11
Paul Brown, Vishnu Sresht, Burak H Eral, Andrew Fiore, César de la Fuente-Núñez, Marcus O'Mahony, Gabriel P Mendes, William T Heller, Patrick S Doyle, Daniel Blankschtein, T Alan Hatton
This article reports on a new class of stimuli-responsive surfactant generated from commercially available amphiphiles such as dodecyltrimethylammmonium bromide (DTAB) by substitution of the halide counterion with counterions such as 2-cyanopyrrolide, 1,2,3-triazolide, and L-proline that complex reversibly with CO2. Through a combination of small-angle neutron scattering (SANS), electrical conductivity measurements, thermal gravimetric analysis, and molecular dynamics simulations, we show how small changes in charge reorganization and counterion shape and size induced by complexation with CO2 allow for fine-tunability of surfactant properties...
July 24, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28686851/characterization-of-brown-adipose-like-tissue-in%C3%A2-trauma-induced-heterotopic-ossification-in%C3%A2-humans
#12
Elizabeth A Salisbury, Austin R Dickerson, Thomas A Davis, Jonathan A Forsberg, Alan R Davis, Elizabeth A Olmsted-Davis
Heterotopic ossification (HO), the abnormal formation of bone within soft tissues, is a major complication after severe trauma or amputation. Transient brown adipocytes have been shown to be a critical regulator of this process in a mouse model of HO. In this study, we evaluated the presence of brown fat within human HO lesions. Most of the excised tissue samples displayed histological characteristics of bone, fibroproliferative cells, blood vessels, and adipose tissue. Immunohistochemical analysis revealed extensive expression of uncoupling protein 1 (UCP1), a definitive marker of brown adipocytes, within HO-containing tissues but not normal tissues...
July 4, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28682065/discovery-of-clinical-candidate-4-2-5-amino-1h-pyrazol-4-yl-4-chlorophenoxy-5-chloro-2-fluoro-n-1-3-thiazol-4-ylbenzenesulfonamide-pf-05089771-design-and-optimization-of-diaryl-ether-aryl-sulfonamides-as-selective-inhibitors-of-nav1-7
#13
Nigel A Swain, Dave Batchelor, Serge Beaudoin, Bruce M Bechle, Paul A Bradley, Alan D Brown, Bruce Brown, Ken J Butcher, Richard P Butt, Mark L Chapman, Stephen Denton, David Ellis, Sebastien R G Galan, Steven M Gaulier, Ben S Greener, Marcel J de Groot, Mel S Glossop, Ian K Gurrell, Jo Hannam, Matthew S Johnson, Zhixin Lin, Christopher J Markworth, Brian E Marron, David S Millan, Shoko Nakagawa, Andy Pike, David Printzenhoff, David J Rawson, Sarah J Ransley, Steven M Reister, Kosuke Sasaki, R Ian Storer, Paul A Stupple, Christopher W West
A series of acidic diaryl ether heterocyclic sulfonamides that are potent and subtype selective NaV1.7 inhibitors is described. Optimization of early lead matter focused on removal of structural alerts, improving metabolic stability and reducing cytochrome P450 inhibition driven drug-drug interaction concerns to deliver the desired balance of preclinical in vitro properties. Concerns over nonmetabolic routes of clearance, variable clearance in preclinical species, and subsequent low confidence human pharmacokinetic predictions led to the decision to conduct a human microdose study to determine clinical pharmacokinetics...
August 10, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28681680/evolution-of-chemical-specific-adjustment-factors-csaf-based-on-recent-international-experience-increasing-utility-and-facilitating-regulatory-acceptance
#14
Virunya S Bhat, M E Bette Meek, Mathieu Valcke, Caroline English, Alan Boobis, Richard Brown
The application of chemical-specific toxicokinetic or toxicodynamic data to address interspecies differences and human variability in the quantification of hazard has potential to reduce uncertainty and better characterize variability compared with the use of traditional default or categorically-based uncertainty factors. The present review summarizes the state-of-the-science since the introduction of the World Health Organization/International Programme on Chemical Safety (WHO/IPCS) guidance on chemical-specific adjustment factors (CSAF) in 2005 and the availability of recent applicable guidance including the WHO/IPCS guidance on physiologically-based pharmacokinetic (PBPK) modeling in 2010 as well as the U...
July 6, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28652467/systolic-blood-pressure-and-biochemical-assessment-of-adherence-a-cross-sectional-analysis-in-the-emergency-department
#15
Candace D McNaughton, Nancy J Brown, Russell L Rothman, Dandan Liu, Edmond K Kabagambe, Phillip D Levy, Wesley H Self, Alan B Storrow, Sean P Collins, Christianne L Roumie
Elevated blood pressure (BP) is common in the emergency department (ED), but the relationship between antihypertensive medication adherence and BP in the ED is unclear. This cross-sectional study tested the hypothesis that higher antihypertensive adherence is associated with lower systolic BP (SBP) in the ED among adults with hypertension who sought ED care at an academic hospital from July 2012 to April 2013. Biochemical assessment of antihypertensive adherence was performed using a mass spectrometry blood assay, and the primary outcome was average ED SBP...
August 2017: Hypertension
https://www.readbyqxmd.com/read/28645284/healthcare-expenditure-on-indigenous-and-non-indigenous-australians-at-high-risk-of-cardiovascular-disease
#16
Blake Angell, Tracey-Lea Laba, Tom Lung, Alex Brown, Sandra Eades, Tim Usherwood, David Peiris, Laurent Billot, Graham Hillis, Ruth Webster, Andrew Tonkin, Christopher Reid, Barbara Molanus, Natasha Rafter, Alan Cass, Anushka Patel, Stephen Jan
BACKGROUND: In spite of bearing a heavier burden of death, disease and disability, there is mixed evidence as to whether Indigenous Australians utilise more or less healthcare services than other Australians given their elevated risk level. This study analyses the Medicare expenditure and its predictors in a cohort of Indigenous and non-Indigenous Australians at high risk of cardiovascular disease. METHODS: The healthcare expenditure of participants of the Kanyini Guidelines Adherence with the Polypill (GAP) pragmatic randomised controlled trial was modelled using linear regression methods...
June 23, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28643852/therapeutic-d2-3-receptor-occupancies-and-response-with-low-amisulpride-blood-concentrations-in-very-late-onset-schizophrenia-like-psychosis-vloslp
#17
Suzanne Reeves, Kate Eggleston, Elizabeth Cort, Emma McLachlan, Stuart Brownings, Akshay Nair, Suki Greaves, Alan Smith, Joel Dunn, Paul Marsden, Robert Kessler, David Taylor, Julie Bertrand, Robert Howard
OBJECTIVE: Antipsychotic drug sensitivity in very late-onset schizophrenia-like psychosis (VLOSLP) is well documented, but poorly understood. This study aimed to investigate blood drug concentration, D2/3 receptor occupancy and outcome in VLOSLP during open amisulpride prescribing, and compare this with Alzheimer's disease (AD). METHODS: Blood drug concentration, prolactin, symptoms and extrapyramidal side-effects (EPS) were serially assessed during dose titration...
June 23, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28636705/inflammation-in-the-neurocircuitry-of-obsessive-compulsive-disorder
#18
Sophia Attwells, Elaine Setiawan, Alan A Wilson, Pablo M Rusjan, Romina Mizrahi, Laura Miler, Cynthia Xu, Margaret Anne Richter, Alan Kahn, Stephen J Kish, Sylvain Houle, Lakshmi Ravindran, Jeffrey H Meyer
Importance: For a small percentage of obsessive-compulsive disorder (OCD) cases exhibiting additional neuropsychiatric symptoms, it was proposed that neuroinflammation occurs in the basal ganglia as an autoimmune response to infections. However, it is possible that elevated neuroinflammation, inducible by a diverse range of mechanisms, is important throughout the cortico-striato-thalamo-cortical circuit of OCD. Identifying brain inflammation is possible with the recent advance in positron emission tomography (PET) radioligands that bind to the translocator protein (TSPO)...
August 1, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28631889/microrna-containing-extracellular-vesicles-released-from-endothelial-colony-forming-cells-modulate-angiogenesis-during-ischaemic-retinopathy
#19
Margaret Dellett, Eoin D Brown, Jasenka Guduric-Fuchs, Anna O'Connor, Alan W Stitt, Reinhold J Medina, David A Simpson
Endothelial colony-forming cells (ECFCs) are a defined subtype of endothelial progenitors that modulate vascular repair and promote perfusion in ischaemic tissues. Their paracrine activity on resident vasculature is ill-defined, but mediated, at least in part, by the transfer of extracellular vesicles (EVs). To evaluate the potential of isolated EVs to provide an alternative to cell-based therapies, we first performed a physical and molecular characterization of those released by ECFCs. Their effects upon endothelial cells in vitro and angiogenesis in vivo in a model of proliferative retinopathy were assessed...
June 20, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28628793/the-reliability-concurrent-validity-and-association-with-salivary-oxytocin-of-the-self-report-version-of-the-inventory-of-callous-unemotional-traits-in-adolescents-with-conduct-disorder
#20
Tomer Levy, Alan Apter, Amir Djalovski, Miriam Peskin, Silvana Fennig, Galia Gat-Yablonski, Meytal Bar-Maisels, Katy Borodkin, Yuval Bloch
The present study evaluated the self-report version of the Inventory of Callous-Unemotional Traits (ICU-SR) in terms of reliability, concurrent validity, and correlation with salivary oxytocin levels, a potential biomarker of CU traits. 67 socially at-risk male adolescents (mean 16.2 years) completed the ICU-SR, ICU teacher-version (ICU-TR), Strengths and Difficulties Questionnaire, and their medical files were coded for previous antisocial acts using Brown-Goodwin Lifetime Aggression Scale. Salivary samples were assayed for oxytocin...
June 12, 2017: Psychiatry Research
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