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JOURNAL ARTICLE
Peter Lz Labib, Thomas B Russell, Jemimah L Denson, Mark A Puckett, Fabio Ausania, Elizabeth Pando, Keith J Roberts, Ambareen Kausar, Vasileios K Mavroeidis, Ricky H Bhogal, Gabriele Marangoni, Sarah C Thomasset, Adam E Frampton, Duncan R Spalding, Pavlos Lykoudis, Ruben Bellotti, Nassir Alhaboob, Parthi Srinivasan, Hassaan Bari, Andrew Smith, Ismael Dominguez-Rosado, Daniel Croagh, Rohan G Thakkar, Dhanny Gomez, Michael A Silva, Pierfrancesco Lapolla, Andrea Mingoli, Brian R Davidson, Alberto Porcu, Nehal S Shah, Zaed Z Hamady, Bilal A Al-Sarireh, Alejandro Serrablo, Somaiah Aroori
INTRODUCTION: Patients undergoing pancreaticoduodenectomy for distal cholangiocarcinoma (dCCA) often develop cancer recurrence. Establishing timing, patterns and risk factors for recurrence may help inform surveillance protocol strategies or select patients who could benefit from additional systemic or locoregional therapies. This multicentre retrospective cohort study aimed to determine timing, patterns, and predictive factors of recurrence following pancreaticoduodenectomy for dCCA...
April 22, 2024: European Journal of Surgical Oncology
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JOURNAL ARTICLE
Emma Taylor-Salmon, Verity Hill, Lauren M Paul, Robert T Koch, Mallery I Breban, Chrispin Chaguza, Afeez Sodeinde, Joshua L Warren, Sylvia Bunch, Natalia Cano, Marshall Cone, Sarah Eysoldt, Alezaundra Garcia, Nicadia Gilles, Andrew Hagy, Lea Heberlein, Rayah Jaber, Elizabeth Kassens, Pamela Colarusso, Amanda Davis, Samantha Baudin, Edhelene Rico, Álvaro Mejía-Echeverri, Blake Scott, Danielle Stanek, Rebecca Zimler, Jorge L Muñoz-Jordán, Gilberto A Santiago, Laura E Adams, Gabriela Paz-Bailey, Melanie Spillane, Volha Katebi, Robert Paulino-Ramírez, Sayira Mueses, Armando Peguero, Nelissa Sánchez, Francesca F Norman, Juan-Carlos Galán, Ralph Huits, Davidson H Hamer, Chantal B F Vogels, Andrea Morrison, Scott F Michael, Nathan D Grubaugh
Dengue is the most prevalent mosquito-borne viral disease in humans, and cases are continuing to rise globally. In particular, islands in the Caribbean have experienced more frequent outbreaks, and all four dengue virus (DENV) serotypes have been reported in the region, leading to hyperendemicity and increased rates of severe disease. However, there is significant variability regarding virus surveillance and reporting between islands, making it difficult to obtain an accurate understanding of the epidemiological patterns in the Caribbean...
April 25, 2024: Nature Communications
#3
JOURNAL ARTICLE
Benjamin S Frank, Sierra Niemiec, Ludmila Khailova, Christopher A Mancuso, Tanner Lehmann, Max B Mitchell, Gareth J Morgan, Mark Twite, Michael V DiMaria, Jelena Klawitter, Jesse A Davidson
BACKGROUND: Infants with single ventricle heart disease (SVHD) suffer morbidity from insufficient pulmonary blood flow, which may be related to impaired arginine metabolism. No prior study has reported quantitative mapping of arginine metabolites to evaluate the relationship between circulating metabolite levels and outcomes. METHODS: Prospective cohort study of 75 SVHD cases peri-Stage 2 and 50 healthy controls. We targeted pre- and post-op absolute serum quantification of 9 key members of the arginine metabolism pathway by tandem mass spectrometry...
April 2, 2024: Pediatric Research
#4
JOURNAL ARTICLE
Philip M Carlucci, Katherine Preisinger, Kristina K Deonaraine, Devyn Zaminski, Maria Dall'Era, Heather T Gold, Kenneth Kalunian, Andrea Fava, H Michael Belmont, Ming Wu, Chaim Putterman, Jennifer Anolik, Jennifer L Barnas, Richard Furie, Betty Diamond, Anne Davidson, David Wofsy, Diane Kamen, Judith A James, Joel M Guthridge, William Apruzzese, Deepak Rao, Michael H Weisman, Peter M Izmirly, Jill Buyon, Michelle Petri
OBJECTIVE: Lupus nephritis (LN) can occur as an isolated component of disease activity or be accompanied by diverse extrarenal manifestations. Whether isolated renal disease is sufficient to decrease health related quality of life (HRQOL) remains unknown. This study compared Patient-Reported Outcomes Measurement Information System 29-Item (PROMIS-29) scores in LN patients with isolated renal disease to those with extrarenal symptoms to evaluate the burden of LN on HRQOL and inform future LN clinical trials incorporating HRQOL outcomes...
March 26, 2024: Rheumatology
#5
JOURNAL ARTICLE
Christopher J Farina, Michael H Davidson, Prediman K Shah, Charles Stark, Wenqi Lu, Cheerag Shirodaria, Timothy Wright, Charalambos A Antoniades, Jan Nilsson, Nehal N Mehta
No abstract text is available yet for this article.
March 25, 2024: Cardiovascular Research
#6
EDITORIAL
Ralph Huits, Nathan D Grubaugh, Michael Libman, Davidson H Hamer
No abstract text is available yet for this article.
March 19, 2024: Annals of Internal Medicine
#7
JOURNAL ARTICLE
Peter M Izmirly, Mimi Y Kim, Philip M Carlucci, Katherine Preisinger, Brooke Z Cohen, Kristina Deonaraine, Devyn Zaminski, Maria Dall'Era, Kenneth Kalunian, Andrea Fava, H Michael Belmont, Ming Wu, Chaim Putterman, Jennifer Anolik, Jennifer L Barnas, Betty Diamond, Anne Davidson, David Wofsy, Diane Kamen, Judith A James, Joel M Guthridge, William Apruzzese, Deepak A Rao, Michael H Weisman, Michelle Petri, Jill Buyon, Richard Furie
BACKGROUND: Leveraging the Accelerating Medicines Partnership (AMP) Lupus Nephritis (LN) dataset, we evaluated longitudinal patterns, rates, and predictors of response to standard-of-care therapy in patients with lupus nephritis. METHODS: Patients from US academic medical centers with class III, IV, and/or V LN and a baseline urine protein/creatinine (UPCR) ratio ≥ 1.0 (n = 180) were eligible for this analysis. Complete response (CR) required the following: (1) UPCR < 0...
February 20, 2024: Arthritis Research & Therapy
#8
JOURNAL ARTICLE
Michael T H Ng, Rowie Borst, Hamez Gacaferi, Sarah Davidson, Jessica E Ackerman, Peter A Johnson, Caio C Machado, Ian Reekie, Moustafa Attar, Dylan Windell, Mariola Kurowska-Stolarska, Lucy MacDonald, Stefano Alivernini, Micon Garvilles, Kathrin Jansen, Ananya Bhalla, Angela Lee, James Charlesworth, Rajat Chowdhury, Paul Klenerman, Kate Powell, Carl-Philip Hackstein, Dominic Furniss, Jonathan Rees, Derek Gilroy, Mark Coles, Andrew J Carr, Stephen N Sansom, Christopher D Buckley, Stephanie G Dakin
Frozen shoulder is a spontaneously self-resolving chronic inflammatory fibrotic human disease, which distinguishes the condition from most fibrotic diseases that are progressive and irreversible. Using single-cell analysis, we identify pro-inflammatory MERTKlow CD48+ macrophages and MERTK + LYVE1 + MRC1+ macrophages enriched for negative regulators of inflammation which co-exist in frozen shoulder capsule tissues. Micro-cultures of patient-derived cells identify integrin-mediated cell-matrix interactions between MERTK+ macrophages and pro-resolving DKK3+ and POSTN+ fibroblasts, suggesting that matrix remodelling plays a role in frozen shoulder resolution...
February 19, 2024: Nature Communications
#9
JOURNAL ARTICLE
Ghader Bashiri, Esther M M Bulloch, William R Bramley, Madison Davidson, Stephanie M Stuteley, Paul G Young, Paul W R Harris, Muhammad S H Naqvi, Martin J Middleditch, Michael Schmitz, Wei-Chen Chang, Edward N Baker, Christopher J Squire
Poly-γ-glutamate tails are a distinctive feature of archaeal, bacterial, and eukaryotic cofactors, including the folates and F420 . Despite decades of research, key mechanistic questions remain as to how enzymes successively add glutamates to poly-γ-glutamate chains while maintaining cofactor specificity. Here, we show how poly-γ-glutamylation of folate and F420 by folylpolyglutamate synthases and γ-glutamyl ligases, non-homologous enzymes, occurs via processive addition of L-glutamate onto growing γ-glutamyl chain termini...
February 12, 2024: Nature Communications
#10
Alice Horisberger, Alec Griffith, Joshua Keegan, Arnon Arazi, John Pulford, Ekaterina Murzin, Kaitlyn Howard, Brandon Hancock, Andrea Fava, Takanori Sasaki, Tusharkanti Ghosh, Jun Inamo, Rebecca Beuschel, Ye Cao, Katie Preisinger, Maria Gutierrez-Arcelus, Thomas M Eisenhaure, Joel Guthridge, Paul J Hoover, Maria Dall'Era, David Wofsy, Diane L Kamen, Kenneth C Kalunian, Richard Furie, Michael Belmont, Peter Izmirly, Robert Clancy, David Hildeman, E Steve Woodle, William Apruzzese, Maureen A McMahon, Jennifer Grossman, Jennifer L Barnas, Fernanda Payan-Schober, Mariko Ishimori, Michael Weisman, Matthias Kretzler, Celine C Berthier, Jeffrey B Hodgin, Dawit S Demeke, Chaim Putterman, Michael B Brenner, Jennifer H Anolik, Soumya Raychaudhuri, Nir Hacohen, Judith A James, Anne Davidson, Michelle A Petri, Jill P Buyon, Betty Diamond, Fan Zhang, James A Lederer, Deepak A Rao
Lupus nephritis (LN) is a frequent manifestation of systemic lupus erythematosus, and fewer than half of patients achieve complete renal response with standard immunosuppressants. Identifying non-invasive, blood-based pathologic immune alterations associated with renal injury could aid therapeutic decisions. Here, we used mass cytometry immunophenotyping of peripheral blood mononuclear cells in 145 patients with biopsy-proven LN and 40 healthy controls to evaluate the heterogeneity of immune activation in patients with LN and to identify correlates of renal parameters and treatment response...
March 9, 2024: bioRxiv
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JOURNAL ARTICLE
Andrea Fava, Jill Buyon, Laurence Magder, Jeff Hodgin, Avi Rosenberg, Dawit S Demeke, Deepak A Rao, Arnon Arazi, Alessandra Ida Celia, Chaim Putterman, Jennifer H Anolik, Jennifer Barnas, Maria Dall'Era, David Wofsy, Richard Furie, Diane Kamen, Kenneth Kalunian, Judith A James, Joel Guthridge, Mohamed G Atta, Jose Monroy Trujillo, Derek Fine, Robert Clancy, H Michael Belmont, Peter Izmirly, William Apruzzese, Daniel Goldman, Celine C Berthier, Paul Hoover, Nir Hacohen, Soumya Raychaudhuri, Anne Davidson, Betty Diamond, Michelle Petri
Lupus nephritis (LN) is a pathologically heterogenous autoimmune disease linked to end-stage kidney disease and mortality. Better therapeutic strategies are needed as only 30%-40% of patients completely respond to treatment. Noninvasive biomarkers of intrarenal inflammation may guide more precise approaches. Because urine collects the byproducts of kidney inflammation, we studied the urine proteomic profiles of 225 patients with LN (573 samples) in the longitudinal Accelerating Medicines Partnership in RA/SLE cohort...
January 23, 2024: JCI Insight
#12
JOURNAL ARTICLE
Stan Heidema, Ivo V Stoepker, Gerard Flaherty, Kristina M Angelo, Richard A J Post, Charles Miller, Michael Libman, Davidson H Hamer, Edwin R van den Heuvel, Ralph Huits
No abstract text is available yet for this article.
January 17, 2024: Journal of Travel Medicine
#13
JOURNAL ARTICLE
Elizabeth A Hazel, Daniel J Erchick, Joanne Katz, Anne C C Lee, Michael Diaz, Lee S F Wu, Keith P West, Abu Ahmed Shamim, Parul Christian, Hasmot Ali, Abdullah H Baqui, Samir K Saha, Salahuddin Ahmed, Arunangshu Dutta Roy, Mariângela F Silveira, Romina Buffarini, Roger Shapiro, Rebecca Zash, Patrick Kolsteren, Carl Lachat, Lieven Huybregts, Dominique Roberfroid, Zhonghai Zhu, Lingxia Zeng, Seifu H Gebreyesus, Kokeb Tesfamariam, Seth Adu-Afarwuah, Kathryn G Dewey, Stephaney Gyaase, Kwaku Poku-Asante, Ellen Boamah Kaali, Darby Jack, Thulasiraj Ravilla, James Tielsch, Sunita Taneja, Ranadip Chowdhury, Per Ashorn, Kenneth Maleta, Ulla Ashorn, Charles Mangani, Luke C Mullany, Subarna K Khatry, Vundli Ramokolo, Wanga Zembe-Mkabile, Wafaie W Fawzi, Dongqing Wang, Christentze Schmiegelow, Daniel Minja, Omari Abdul Msemo, John P A Lusingu, Emily R Smith, Honorati Masanja, Aroonsri Mongkolchati, Paniya Keentupthai, Abel Kakuru, Richard Kajubi, Katherine Semrau, Davidson H Hamer, Albert Manasyan, Jake M Pry, Bernard Chasekwa, Jean Humphrey, Robert E Black
OBJECTIVE: To describe the mortality risks by fine strata of gestational age and birthweight among 230 679 live births in nine low- and middle-income countries (LMICs) from 2000 to 2017. DESIGN: Descriptive multi-country secondary data analysis. SETTING: Nine LMICs in sub-Saharan Africa, Southern and Eastern Asia, and Latin America. POPULATION: Liveborn infants from 15 population-based cohorts. METHODS: Subnational, population-based studies with high-quality birth outcome data were invited to join the Vulnerable Newborn Measurement Collaboration...
January 16, 2024: BJOG: An International Journal of Obstetrics and Gynaecology
#14
JOURNAL ARTICLE
Kendall H Burks, Yan Xie, Michael Gildea, In-Hyuk Jung, Sandip Mukherjee, Paul Lee, Upasana Pudupakkam, Ryan Wagoner, Ved Patel, Katherine Santana, Arturo Alisio, Ira J Goldberg, Brian N Finck, Edward A Fisher, Nicholas O Davidson, Nathan O Stitziel
Angiopoietin-like protein 3 (ANGPTL3) is a hepatically secreted protein and therapeutic target for reducing plasma triglyceride-rich lipoproteins (TRL) and low-density lipoprotein cholesterol (LDL). Although ANGPTL3 modulates the metabolism of circulating lipoproteins, its role in TRL assembly and secretion remains unknown. CRISPR-associated protein 9 (CRISPR/Cas9) was used to target ANGPTL3 in HepG2 cells (ANGPTL3-/- ) whereupon we observed ∼50% reduction of ApoB100 secretion, accompanied by an increase in ApoB100 early presecretory degradation by a predominantly lysosomal mechanism...
January 12, 2024: Journal of Lipid Research
#15
JOURNAL ARTICLE
Rachel Bierbrier, Emilie Javelle, Francesca F Norman, Lin Hwei Chen, Emmanuel Bottieau, Eli Schwartz, Karin Leder, Kristina M Angelo, Rhett Stoney, Michael Libman, Davidson H Hamer, Ralph Huits, Bradley A Connor, Fabrice Simon, Sapha Barkati
BACKGROUND: Chikungunya is an important travel-related disease because of its rapid geographical expansion and potential for prolonged morbidity. Improved understanding of the epidemiology of travel-related chikungunya infections may influence prevention strategies including education and vaccination. METHODS: We analysed data from travellers with confirmed or probable chikungunya reported to GeoSentinel sites from 2005 to 2020. Confirmed chikungunya was defined as a compatible clinical history plus either virus isolation, positive nucleic acid test, or seroconversion/rising titre in paired sera...
January 9, 2024: Journal of Travel Medicine
#16
JOURNAL ARTICLE
Ashley A Huggins, C Lexi Baird, Melvin Briggs, Sarah Laskowitz, Ahmed Hussain, Samar Fouda, Courtney Haswell, Delin Sun, Lauren E Salminen, Neda Jahanshad, Sophia I Thomopoulos, Dick J Veltman, Jessie L Frijling, Miranda Olff, Mirjam van Zuiden, Saskia B J Koch, Laura Nawjin, Li Wang, Ye Zhu, Gen Li, Dan J Stein, Jonathan Ipser, Soraya Seedat, Stefan du Plessis, Leigh L van den Heuvel, Benjamin Suarez-Jimenez, Xi Zhu, Yoojean Kim, Xiaofu He, Sigal Zilcha-Mano, Amit Lazarov, Yuval Neria, Jennifer S Stevens, Kerry J Ressler, Tanja Jovanovic, Sanne J H van Rooij, Negar Fani, Anna R Hudson, Sven C Mueller, Anika Sierk, Antje Manthey, Henrik Walter, Judith K Daniels, Christian Schmahl, Julia I Herzog, Pavel Říha, Ivan Rektor, Lauren A M Lebois, Milissa L Kaufman, Elizabeth A Olson, Justin T Baker, Isabelle M Rosso, Anthony P King, Isreal Liberzon, Mike Angstadt, Nicholas D Davenport, Scott R Sponheim, Seth G Disner, Thomas Straube, David Hofmann, Rongfeng Qi, Guang Ming Lu, Lee A Baugh, Gina L Forster, Raluca M Simons, Jeffrey S Simons, Vincent A Magnotta, Kelene A Fercho, Adi Maron-Katz, Amit Etkin, Andrew S Cotton, Erin N O'Leary, Hong Xie, Xin Wang, Yann Quidé, Wissam El-Hage, Shmuel Lissek, Hannah Berg, Steven Bruce, Josh Cisler, Marisa Ross, Ryan J Herringa, Daniel W Grupe, Jack B Nitschke, Richard J Davidson, Christine L Larson, Terri A deRoon-Cassini, Carissa W Tomas, Jacklynn M Fitzgerald, Jennifer Urbano Blackford, Bunmi O Olatunji, William S Kremen, Michael J Lyons, Carol E Franz, Evan M Gordon, Geoffrey May, Steven M Nelson, Chadi G Abdallah, Ifat Levy, Ilan Harpaz-Rotem, John H Krystal, Emily L Dennis, David F Tate, David X Cifu, William C Walker, Elizabeth A Wilde, Ian H Harding, Rebecca Kerestes, Paul M Thompson, Rajendra Morey
Although the cerebellum contributes to higher-order cognitive and emotional functions relevant to posttraumatic stress disorder (PTSD), prior research on cerebellar volume in PTSD is scant, particularly when considering subregions that differentially map on to motor, cognitive, and affective functions. In a sample of 4215 adults (PTSD n = 1642; Control n = 2573) across 40 sites from the ENIGMA-PGC PTSD working group, we employed a new state-of-the-art deep-learning based approach for automatic cerebellar parcellation to obtain volumetric estimates for the total cerebellum and 28 subregions...
January 10, 2024: Molecular Psychiatry
#17
JOURNAL ARTICLE
Maxwell P Gold, Winnie Ong, Andrew M Masteller, David R Ghasemi, Julie Anne Galindo, Noel R Park, Nhan C Huynh, Aneesh Donde, Veronika Pister, Raul A Saurez, Maria C Vladoiu, Grace H Hwang, Tanja Eisemann, Laura K Donovan, Adam D Walker, Joseph Benetatos, Christelle Dufour, Livia Garzia, Rosalind A Segal, Robert J Wechsler-Reya, Jill P Mesirov, Andrey Korshunov, Kristian W Pajtler, Scott L Pomeroy, Olivier Ayrault, Shawn M Davidson, Jennifer A Cotter, Michael D Taylor, Ernest Fraenkel
Many genes that drive normal cellular development also contribute to oncogenesis. Medulloblastoma (MB) tumors likely arise from neuronal progenitors in the cerebellum, and we hypothesized that the heterogeneity observed in MBs with sonic hedgehog (SHH) activation could be due to differences in developmental pathways. To investigate this question, here we perform single-nucleus RNA sequencing on highly differentiated SHH MBs with extensively nodular histology and observed malignant cells resembling each stage of canonical granule neuron development...
January 8, 2024: Nature Communications
#18
JOURNAL ARTICLE
Vi Pham, Livia Sertori Finoti, Margaret M Cassidy, Jean Ann Maguire, Alyssa L Gagne, Elisa A Waxman, Deborah L French, Kaitlyn King, Zitao Zhou, Michael H Gelb, Parith Wongkittichotee, Xinying Hong, Lars Schlotawa, Beverly L Davidson, Rebecca C Ahrens-Nicklas
Multiple sulfatase deficiency (MSD) is an ultra-rare, inherited lysosomal storage disease caused by mutations in the gene sulfatase modifying factor 1 (SUMF1). MSD is characterized by the functional deficiency of all sulfatase enzymes, leading to the storage of sulfated substrates including glycosaminoglycans (GAGs), sulfolipids, and steroid sulfates. Patients with MSD experience severe neurological impairment, hearing loss, organomegaly, corneal clouding, cardiac valve disease, dysostosis multiplex, contractures, and ichthyosis...
December 21, 2023: Molecular Genetics and Metabolism
#19
REVIEW
John J P Kastelein, Andrew Hsieh, Mary R Dicklin, Marc Ditmarsch, Michael H Davidson
PURPOSE OF REVIEW: To discuss the history of cardiovascular outcomes trials of cholesteryl ester transfer protein (CETP) inhibitors and to describe obicetrapib, a next-generation, oral, once-daily, low-dose CETP inhibitor in late-stage development for dyslipidemia and atherosclerotic cardiovascular disease (ASCVD). RECENT FINDINGS: Phase 1 and 2 trials have evaluated the safety and lipid/lipoprotein effects of obicetrapib as monotherapy, in conjunction with statins, on top of high-intensity statins (HIS), and with ezetimibe on top of HIS...
December 22, 2023: Current Atherosclerosis Reports
#20
JOURNAL ARTICLE
Thomas B Russell, Peter L Labib, Paula Murphy, Fabio Ausania, Elizabeth Pando, Keith J Roberts, Ambareen Kausar, Vasileios K Mavroeidis, Gabriele Marangoni, Sarah C Thomasset, Adam E Frampton, Pavlos Lykoudis, Manuel Maglione, Nassir Alhaboob, Hassaan Bari, Andrew M Smith, Duncan Spalding, Parthi Srinivasan, Brian R Davidson, Ricky H Bhogal, Daniel Croagh, Ismael Dominguez, Rohan Thakkar, Dhanny Gomez, Michael A Silva, Pierfrancesco Lapolla, Andrea Mingoli, Alberto Porcu, Nehal S Shah, Zaed Z R Hamady, Bilal Al-Sarrieh, Alejandro Serrablo, Somaiah Aroori
BACKGROUNDS/AIMS: After pancreatoduodenectomy (PD), an early oral diet is recommended; however, the postoperative nutritional management of PD patients is known to be highly variable, with some centers still routinely providing parenteral nutrition (PN). Some patients who receive PN experience clinically significant complications, underscoring its judicious use. Using a large cohort, this study aimed to determine the proportion of PD patients who received postoperative nutritional support (NS), describe the nature of this support, and investigate whether receiving PN correlated with adverse perioperative outcomes...
December 14, 2023: Annals of Hepato-Biliary-Pancreatic Surgery
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