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Michael H Davidson

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https://www.readbyqxmd.com/read/27919362/the-effect-of-omega-3-carboxylic-acids-on-apolipoprotein-ciii-containing-lipoproteins-in-severe-hypertriglyceridemia
#1
Allyson M Morton, Jeremy D Furtado, Jane Lee, William Amerine, Michael H Davidson, Frank M Sacks
BACKGROUND: Lipoprotein subspecies containing apoCIII adversely affect cardiovascular disease (CVD) risk; for example, low density lipoprotein (LDL) with apoCIII is a stronger CVD predictor than LDL without apoCIII. The Epanova for Lowering Very High Triglycerides (EVOLVE) trial showed that Epanova (omega-3 carboxylic acids [OM3-CA]) significantly lowered TG and apoCIII but raised LDL-C. However, it is unknown what subspecies of LDL were affected by treatment. OBJECTIVE: To determine how lipoprotein subspecies are affected by omega-3 fatty acid treatment, we studied the effect of OM3-CA on apoCIII concentrations in high density lipoprotein (HDL), LDL, and very low density lipoprotein (VLDL) and on the concentrations of subspecies of HDL, LDL, and VLDL that contain or do not contain apoCIII...
November 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27919182/treatment-resistant-schizophrenia-treatment-response-and-resistance-in-psychosis-trrip-working-group-consensus-guidelines-on-diagnosis-and-terminology
#2
Oliver D Howes, Rob McCutcheon, Ofer Agid, Andrea de Bartolomeis, Nico J M van Beveren, Michael L Birnbaum, Michael A P Bloomfield, Rodrigo A Bressan, Robert W Buchanan, William T Carpenter, David J Castle, Leslie Citrome, Zafiris J Daskalakis, Michael Davidson, Richard J Drake, Serdar Dursun, Bjørn H Ebdrup, Helio Elkis, Peter Falkai, W Wolfgang Fleischacker, Ary Gadelha, Fiona Gaughran, Birte Y Glenthøj, Ariel Graff-Guerrero, Jaime E C Hallak, William G Honer, James Kennedy, Bruce J Kinon, Stephen M Lawrie, Jimmy Lee, F Markus Leweke, James H MacCabe, Carolyn B McNabb, Herbert Meltzer, Hans-Jürgen Möller, Shinchiro Nakajima, Christos Pantelis, Tiago Reis Marques, Gary Remington, Susan L Rossell, Bruce R Russell, Cynthia O Siu, Takefumi Suzuki, Iris E Sommer, David Taylor, Neil Thomas, Alp Üçok, Daniel Umbricht, James T R Walters, John Kane, Christoph U Correll
OBJECTIVE: Research and clinical translation in schizophrenia is limited by inconsistent definitions of treatment resistance and response. To address this issue, the authors evaluated current approaches and then developed consensus criteria and guidelines. METHOD: A systematic review of randomized antipsychotic clinical trials in treatment-resistant schizophrenia was performed, and definitions of treatment resistance were extracted. Subsequently, consensus operationalized criteria were developed through 1) a multiphase, mixed methods approach, 2) identification of key criteria via an online survey, and 3) meetings to achieve consensus...
December 6, 2016: American Journal of Psychiatry
https://www.readbyqxmd.com/read/27893080/travel-associated-zika-virus-disease-acquired-in-the-americas-through-february-2016-a-geosentinel-analysis
#3
Davidson H Hamer, Kira A Barbre, Lin H Chen, Martin P Grobusch, Patricia Schlagenhauf, Abraham Goorhuis, Perry J J van Genderen, Israel Molina, Hilmir Asgeirsson, Phyllis E Kozarsky, Eric Caumes, Stefan H Hagmann, Frank P Mockenhaupt, Gilles Eperon, Elizabeth D Barnett, Emmanuel Bottieau, Andrea K Boggild, Philippe Gautret, Noreen A Hynes, Susan Kuhn, R Ryan Lash, Karin Leder, Michael Libman, Denis J M Malvy, Cecilia Perret, Camilla Rothe, Eli Schwartz, Annelies Wilder-Smith, Martin S Cetron, Douglas H Esposito
Background: Zika virus has spread rapidly in the Americas and has been imported into many nonendemic countries by travelers. Objective: To describe clinical manifestations and epidemiology of Zika virus disease in travelers exposed in the Americas. Design: Descriptive, using GeoSentinel records. Setting: 63 travel and tropical medicine clinics in 30 countries. Patients: Ill returned travelers with a confirmed, probable, or clinically suspected diagnosis of Zika virus disease seen between January 2013 and 29 February 2016...
November 22, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27831561/rapidly-cycling-lgr5-stem-cells-are-exquisitely-sensitive-to-extrinsic-dietary-factors-that-modulate-colon-cancer-risk
#4
Eunjoo Kim, Laurie A Davidson, Roger S Zoh, Martha E Hensel, Michael L Salinas, Bhimanagouda S Patil, Guddadarangavvanahally K Jayaprakasha, Evelyn S Callaway, Clinton D Allred, Nancy D Turner, Brad R Weeks, Robert S Chapkin
The majority of colon tumors are driven by aberrant Wnt signaling in intestinal stem cells, which mediates an efficient route toward initiating intestinal cancer. Natural lipophilic polyphenols and long-chain polyunsaturated fatty acids (PUFAs) generally suppress Wnt- and NF-κB- (nuclear factor-κ light-chain enhancer of activated B-cell) related pathways. However, the effects of these extrinsic agents on colonic leucine-rich repeat-containing G-protein-coupled receptor 5-positive (Lgr5(+)) stem cells, the cells of origin of colon cancer, have not been documented to date...
November 10, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27819683/neutralizing-human-antibodies-prevent-zika-virus-replication-and-fetal-disease-in-mice
#5
Gopal Sapparapu, Estefania Fernandez, Nurgun Kose, Bin Cao, Julie M Fox, Robin G Bombardi, Haiyan Zhao, Christopher A Nelson, Aubrey L Bryan, Trevor Barnes, Edgar Davidson, Indira U Mysorekar, Daved H Fremont, Benjamin J Doranz, Michael S Diamond, James E Crowe
Zika virus (ZIKV) is an emerging mosquito-transmitted flavivirus that can cause severe disease, including congenital birth defects during pregnancy(1). To develop candidate therapeutic agents against ZIKV, we isolated a panel of human monoclonal antibodies (mAbs) from subjects with prior ZIKV infection. A subset of mAbs recognized diverse epitopes on the envelope (E) protein and exhibited potently neutralizing activity. One of the most inhibitory mAbs, ZIKV-117, broadly neutralized infection of ZIKV strains corresponding to African, Asian, and American lineages...
November 7, 2016: Nature
https://www.readbyqxmd.com/read/27798489/the-future-of-n-3-polyunsaturated-fatty-acid-therapy
#6
Michael H Davidson, Lane B Benes
PURPOSE OF REVIEW: This article focuses on the potential role by which a complex mixture of omega-3 fatty acids (OM3-FAs) may beneficially modify cardiovascular risk by modifying the cholesterol composition of atherogenic lipoproteins. This hypothesis is being tested in the STRENGTH trial, which is enrolling 13 000 patients on statins at high cardiovascular risk with hypertriglyceridemia and low HDL cholesterol (HDL-C) treated with an OM3-carboxylic acid. RECENT FINDINGS: Complex mixtures of OM3-FAs containing predominately eicosapentanoic acid and docosahexanoic acid in combination with statins lowers non-HDL by reducing triglyceride-rich lipoprotein cholesterol (TRL-C) while shifting small LDL cholesterol (LDL-C) to large LDL-C...
December 2016: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/27784102/primary-care-interventions-to-support-breastfeeding-us-preventive-services-task-force-recommendation-statement
#7
Kirsten Bibbins-Domingo, David C Grossman, Susan J Curry, Karina W Davidson, John W Epling, Francisco A R García, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, William R Phillips, Maureen G Phipps, Michael P Pignone
Importance: There is convincing evidence that breastfeeding provides substantial health benefits for children. However, nearly half of all US mothers who initially breastfeed stop doing so by 6 months, and there are significant disparities in breastfeeding rates among younger mothers and in disadvantaged communities. Objective: To update the 2008 US Preventive Services Task Force (USPSTF) recommendation on primary care interventions to promote breastfeeding. Evidence Review: The USPSTF reviewed the evidence on the effectiveness of interventions to support breastfeeding on breastfeeding initiation, duration, and exclusivity...
October 25, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27777279/reductions-in-atherogenic-lipids-and-major-cardiovascular-events-a-pooled-analysis-of-10-odyssey-trials-comparing-alirocumab-to-control
#8
Kausik K Ray, Henry N Ginsberg, Michael H Davidson, Robert Pordy, Laurence Bessac, Pascal Minini, Robert H Eckel, Christopher P Cannon
BACKGROUND: -A continuous relationship between reductions in low-density lipoprotein cholesterol (LDL-C) and major adverse cardiovascular events (MACE) has been observed in statin and ezetimibe outcomes trials, down to achieved levels of 54 mg/dL. However, it is uncertain whether this relationship extends to LDL-C levels <50 mg/dL. We assessed the relationship between additional LDL-C, non-high-density lipoprotein cholesterol (non-HDL-C), and apolipoprotein B100 (apoB) reductions and MACE among patients within the ODYSSEY trials that compared alirocumab versus controls (placebo/ezetimibe), mainly as add on to maximally tolerated statin...
October 24, 2016: Circulation
https://www.readbyqxmd.com/read/27775925/a-facility-to-search-for-hidden-particles-at-the-cern-sps-the-ship-physics-case
#9
Sergey Alekhin, Wolfgang Altmannshofer, Takehiko Asaka, Brian Batell, Fedor Bezrukov, Kyrylo Bondarenko, Alexey Boyarsky, Ki-Young Choi, Cristóbal Corral, Nathaniel Craig, David Curtin, Sacha Davidson, André de Gouvêa, Stefano Dell'Oro, Patrick deNiverville, P S Bhupal Dev, Herbi Dreiner, Marco Drewes, Shintaro Eijima, Rouven Essig, Anthony Fradette, Björn Garbrecht, Belen Gavela, Gian F Giudice, Mark D Goodsell, Dmitry Gorbunov, Stefania Gori, Christophe Grojean, Alberto Guffanti, Thomas Hambye, Steen H Hansen, Juan Carlos Helo, Pilar Hernandez, Alejandro Ibarra, Artem Ivashko, Eder Izaguirre, Joerg Jaeckel, Yu Seon Jeong, Felix Kahlhoefer, Yonatan Kahn, Andrey Katz, Choong Sun Kim, Sergey Kovalenko, Gordan Krnjaic, Valery E Lyubovitskij, Simone Marcocci, Matthew Mccullough, David McKeen, Guenakh Mitselmakher, Sven-Olaf Moch, Rabindra N Mohapatra, David E Morrissey, Maksym Ovchynnikov, Emmanuel Paschos, Apostolos Pilaftsis, Maxim Pospelov, Mary Hall Reno, Andreas Ringwald, Adam Ritz, Leszek Roszkowski, Valery Rubakov, Oleg Ruchayskiy, Ingo Schienbein, Daniel Schmeier, Kai Schmidt-Hoberg, Pedro Schwaller, Goran Senjanovic, Osamu Seto, Mikhail Shaposhnikov, Lesya Shchutska, Jessie Shelton, Robert Shrock, Brian Shuve, Michael Spannowsky, Andy Spray, Florian Staub, Daniel Stolarski, Matt Strassler, Vladimir Tello, Francesco Tramontano, Anurag Tripathi, Sean Tulin, Francesco Vissani, Martin W Winkler, Kathryn M Zurek
This paper describes the physics case for a new fixed target facility at CERN SPS. The SHiP (search for hidden particles) experiment is intended to hunt for new physics in the largely unexplored domain of very weakly interacting particles with masses below the Fermi scale, inaccessible to the LHC experiments, and to study tau neutrino physics. The same proton beam setup can be used later to look for decays of tau-leptons with lepton flavour number non-conservation, [Formula: see text] and to search for weakly-interacting sub-GeV dark matter candidates...
December 2016: Reports on Progress in Physics
https://www.readbyqxmd.com/read/27626102/diphenylether-modified-1-2-diamines-with-improved-drug-properties-for-development-against-mycobacterium-tuberculosis
#10
Marie H Foss, Sovitj Pou, Patrick M Davidson, Jennifer L Dunaj, Rolf W Winter, Sovijja Pou, Meredith H Licon, Julia K Doh, Yuexin Li, Jane X Kelly, Rozalia A Dodean, Dennis R Koop, Michael K Riscoe, Georgiana E Purdy
New treatments for tuberculosis infection are critical to combat the emergence of multidrug- and extensively drug-resistant Mycobacterium tuberculosis (Mtb). We report the characterization of a diphenylether-modified adamantyl 1,2-diamine that we refer to as TBL-140, which has a minimal inhibitory concentration (MIC99) of 1.2 μg/mL. TBL-140 is effective against drug-resistant Mtb and nonreplicating bacteria. In addition, TBL-140 eliminates expansion of Mtb in cell culture infection assays at its MIC. To define the mechanism of action of this compound, we performed a spontaneous mutant screen and biochemical assays...
July 8, 2016: ACS Infectious Diseases
https://www.readbyqxmd.com/read/27601654/mutations-in-mitochondrial-enzyme-gpt2-cause-metabolic-dysfunction-and-neurological-disease-with-developmental-and-progressive-features
#11
Qing Ouyang, Tojo Nakayama, Ozan Baytas, Shawn M Davidson, Chendong Yang, Michael Schmidt, Sofia B Lizarraga, Sasmita Mishra, Malak Ei-Quessny, Saima Niaz, Mirrat Gul Butt, Syed Imran Murtaza, Afzal Javed, Haroon Rashid Chaudhry, Dylan J Vaughan, R Sean Hill, Jennifer N Partlow, Seung-Yun Yoo, Anh-Thu N Lam, Ramzi Nasir, Muna Al-Saffar, A James Barkovich, Matthew Schwede, Shailender Nagpal, Anna Rajab, Ralph J DeBerardinis, David E Housman, Ganeshwaran H Mochida, Eric M Morrow
Mutations that cause neurological phenotypes are highly informative with regard to mechanisms governing human brain function and disease. We report autosomal recessive mutations in the enzyme glutamate pyruvate transaminase 2 (GPT2) in large kindreds initially ascertained for intellectual and developmental disability (IDD). GPT2 [also known as alanine transaminase 2 (ALT2)] is one of two related transaminases that catalyze the reversible addition of an amino group from glutamate to pyruvate, yielding alanine and α-ketoglutarate...
September 20, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27599331/screening-for-latent-tuberculosis-infection-in-adults-us-preventive-services-task-force-recommendation-statement
#12
COMMENT
Kirsten Bibbins-Domingo, David C Grossman, Susan J Curry, Linda Bauman, Karina W Davidson, John W Epling, Francisco A R García, Jessica Herzstein, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, William R Phillips, Maureen G Phipps, Michael P Pignone
IMPORTANCE: Tuberculosis remains an important preventable disease in the United States. An effective strategy for reducing the transmission, morbidity, and mortality of active disease is the identification and treatment of latent tuberculosis infection (LTBI) to prevent progression to active disease. OBJECTIVE: To issue a current US Preventive Services Task Force (USPSTF) recommendation on screening for LTBI. EVIDENCE REVIEW: The USPSTF reviewed the evidence on screening for LTBI in asymptomatic adults seen in primary care, including evidence dating from the inception of searched databases...
September 6, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27578122/triglyceride-lowering-therapies-reduce-cardiovascular-disease-event-risk-in-subjects-with-hypertriglyceridemia
#13
Kevin C Maki, John R Guyton, Carl E Orringer, Ian Hamilton-Craig, Dominik D Alexander, Michael H Davidson
BACKGROUND: Cardiovascular outcomes trials of fibrates, niacin, or omega-3 fatty acids alone, or added to a statin, have not consistently demonstrated reduced risk, but larger, statistically significant clinical benefits have been reported in subgroups with elevated triglycerides (TG) and/or elevated TG plus low high-density lipoprotein cholesterol (HDL-C). OBJECTIVE: To perform a meta-analysis of the effects of therapies targeting TG and TG-rich lipoprotein cholesterol on cardiovascular disease event risk in subjects with elevated TG or elevated TG paired with low HDL-C...
July 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27532917/screening-for-lipid-disorders-in-children-and-adolescents-us-preventive-services-task-force-recommendation-statement
#14
Kirsten Bibbins-Domingo, David C Grossman, Susan J Curry, Karina W Davidson, John W Epling, Francisco A R García, Matthew W Gillman, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Michael LeFevre, Carol M Mangione, Douglas K Owens, William R Phillips, Maureen G Phipps, Michael P Pignone, Albert L Siu
IMPORTANCE: Elevations in levels of total, low-density lipoprotein, and non-high-density lipoprotein cholesterol; lower levels of high-density lipoprotein cholesterol; and, to a lesser extent, elevated triglyceride levels are associated with risk of cardiovascular disease in adults. OBJECTIVE: To update the 2007 US Preventive Services Task Force (USPSTF) recommendation on screening for lipid disorders in children, adolescents, and young adults. EVIDENCE REVIEW: The USPSTF reviewed the evidence on screening for lipid disorders in children and adolescents 20 years or younger--1 review focused on screening for heterozygous familial hypercholesterolemia, and 1 review focused on screening for multifactorial dyslipidemia...
August 9, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27503844/the-risk-of-hepatotoxicity-new-onset-diabetes-and-rhabdomyolysis-in-the-era-of-high-intensity-statin-therapy-does-statin-type-matter
#15
REVIEW
Lane B Benes, Nikhil S Bassi, Michael H Davidson
The 2013 American College of Cardiology/American Heart Association guidelines on cholesterol management have placed greater emphasis on high-intensity statin dosing for those with known cardiovascular disease or diabetes mellitus. Differences in risk of hepatotoxicity, new onset diabetes and rhabdomyolysis specifically between the high-intensity statins and the most common moderate-intensity statin, simvastatin, were not found to a significant degree in this review. Rather, baseline characteristics and drug-drug interactions (DDIs) appear to be more important regarding the risk of these adverse effects...
September 2016: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/27479357/using-discordance-in-monozygotic-twins-to-understand-causality-of-cardiovascular-disease-risk-factors
#16
David J Davidson, Michael H Davidson
No abstract text is available yet for this article.
October 1, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27458948/screening-for-skin-cancer-us-preventive-services-task-force-recommendation-statement
#17
Kirsten Bibbins-Domingo, David C Grossman, Susan J Curry, Karina W Davidson, Mark Ebell, John W Epling, Francisco A R García, Matthew W Gillman, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, William R Phillips, Maureen G Phipps, Michael P Pignone, Albert L Siu
IMPORTANCE: Basal and squamous cell carcinoma are the most common types of cancer in the United States and represent the vast majority of all cases of skin cancer; however, they rarely result in death or substantial morbidity, whereas melanoma skin cancer has notably higher mortality rates. In 2016, an estimated 76,400 US men and women will develop melanoma and 10,100 will die from the disease. OBJECTIVE: To update the 2009 US Preventive Services Task Force (USPSTF) recommendation on screening for skin cancer...
July 26, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27449089/checkpoint-kinase-1-expression-is-an-adverse-prognostic-marker-and-therapeutic-target-in-myc-driven-medulloblastoma
#18
Eric W Prince, Ilango Balakrishnan, Monil Shah, Jean M Mulcahy Levy, Andrea M Griesinger, Irina Alimova, Peter S Harris, Diane K Birks, Andrew M Donson, Nathan Davidson, Marc Remke, Michael D Taylor, Michael H Handler, Nicholas K Foreman, Sujatha Venkataraman, Rajeev Vibhakar
Checkpoint kinase 1 (CHK1) is an integral component of the cell cycle as well as the DNA Damage Response (DDR) pathway. Previous work has demonstrated the effectiveness of inhibiting CHK1 with small-molecule inhibitors, but the role of CHK1 mediated DDR in medulloblastoma is unknown. CHK1, both at the mRNA and protein level, is highly expressed in medulloblastoma and elevated CHK1 expression in Group3 medulloblastoma is an adverse prognostic marker. CHK1 inhibition with the small-molecule drug AZD7762, results in decreased cell growth, increased DNA damage and cell apoptosis...
July 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/27379742/use-of-decision-models-in-the-development-of-evidence-based-clinical-preventive-services-recommendations-methods-of-the-u-s-preventive-services-task-force
#19
Douglas K Owens, Evelyn P Whitlock, Jillian Henderson, Michael P Pignone, Alex H Krist, Kirsten Bibbins-Domingo, Susan J Curry, Karina W Davidson, Mark Ebell, Matthew W Gillman, David C Grossman, Alex R Kemper, Ann E Kurth, Michael Maciosek, Albert L Siu, Michael L LeFevre
The U.S. Preventive Services Task Force (USPSTF) develops evidence-based recommendations about preventive care based on comprehensive systematic reviews of the best available evidence. Decision models provide a complementary, quantitative approach to support the USPSTF as it deliberates about the evidence and develops recommendations for clinical and policy use. This article describes the rationale for using modeling, an approach to selecting topics for modeling, and how modeling may inform recommendations about clinical preventive services...
October 4, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27304597/screening-for-colorectal-cancer-us-preventive-services-task-force-recommendation-statement
#20
Kirsten Bibbins-Domingo, David C Grossman, Susan J Curry, Karina W Davidson, John W Epling, Francisco A R García, Matthew W Gillman, Diane M Harper, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, Douglas K Owens, William R Phillips, Maureen G Phipps, Michael P Pignone, Albert L Siu
IMPORTANCE: Colorectal cancer is the second leading cause of cancer death in the United States. In 2016, an estimated 134,000 persons will be diagnosed with the disease, and about 49,000 will die from it. Colorectal cancer is most frequently diagnosed among adults aged 65 to 74 years; the median age at death from colorectal cancer is 68 years. OBJECTIVE: To update the 2008 US Preventive Services Task Force (USPSTF) recommendation on screening for colorectal cancer...
June 21, 2016: JAMA: the Journal of the American Medical Association
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