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Hippo signalling

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https://www.readbyqxmd.com/read/29665674/hippo-signaling-circuit-and-divergent-tissue-growth-in-mammalian-eye
#1
Kyeong Hwan Moon, Jin Woo Kim
Vertebrate organ development is accompanied by demarcation of tissue compartments, which grow coordinately with their neighbors. Hence, perturbing the coordinative growth of neighboring tissue compartments frequently results in organ malformation. The growth of tissue compartments is regulated by multiple intercellular and intracellular signaling pathways, including the Hippo signaling pathway that limits the growth of various organs. In the optic neuroepithelial continuum, which is partitioned into the retina, retinal pigment epithelium (RPE) and ciliary margin (CM) during eye development, the Hippo signaling activity operates differentially, as it does in many tissues...
April 11, 2018: Molecules and Cells
https://www.readbyqxmd.com/read/29663987/-effects-of-hippo-signaling-on-anti-oxidative-stress-of-mesenchymal-stem-cells-in-vitro
#2
Lang Li, Liang Dong, Jiaojie Hui, Fei Gao, Qiuhui Wang, Lan Yang, Jiangqian Zhang, Jie Yan
OBJECTIVE: To explore the effects of Hippo signaling on anti-oxidative stress of mouse marrow mesenchymal stem cells (mMSCs) in vitro. METHODS: mMSCs derived from C57BL/6 mice were identified using fluorescence-activated cell sorting analysis and the capabilities of osteogenic, chondrogenic and adipogenic differentiation were evaluated. 2-deoxy-D-glucose (2-DG) or XMU-MP-1 was used to modulate Hippo signaling. Oxidative stress was induced by H2 O2 treatment and the effect of oxidative stress induced by H2 O2 on survival of mMSCs was evaluated using methyl thiazolyl tetrazolium (MTT) assay...
April 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29661847/the-ajuba-lim-protein-wtip-regulates-actomyosin-contractility-during-vertebrate-neural-tube-closure
#3
Chih-Wen Chu, Bo Xiang, Olga Ossipova, Andriani Ioannou, Sergei Y Sokol
Ajuba LIM proteins are implicated in the assembly of cell junctions and have been reported to antagonize Hippo signaling in response to cytoskeletal tension. To assess a role of these proteins in actomyosin contractility, we examined the localization and function of Wtip, a member of the Ajuba family, in Xenopus early embryos. Targeted in vivo depletion of Wtip inhibited apical constriction in neuroepithelial cells and elicited neural tube defects. Fluorescent protein-tagged Wtip showed predominant punctate localization along the cell junctions in the epidermis and a linear junctional pattern in the neuroectoderm...
April 16, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29659518/examining-the-genetic-background-of-porcine-muscle-growth-and-development-based-on-transcriptome-and-mirnaome-data
#4
Katarzyna Ropka-Molik, Klaudia Pawlina-Tyszko, Kacper Żukowski, Katarzyna Piórkowska, Grzegorz Żak, Artur Gurgul, Natalia Derebecka, Joanna Wesoły
Recently, selection in pigs has been focused on improving the lean meat content in carcasses; this focus has been most evident in breeds constituting a paternal component in breeding. Such sire-breeds are used to improve the meat quantity of cross-breed pig lines. However, even in one breed, a significant variation in the meatiness level can be observed. In the present study, the comprehensive analysis of genes and microRNA expression profiles in porcine muscle tissue was applied to identify the genetic background of meat content...
April 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29648608/rab39a-a-rab-small-gtpase-with-a-prominent-role-in-cancer-stemness
#5
Tokuhiro Chano, Sofia Avnet
RAB39A is a Rab small GTPase that localizes at distinct subcellular compartments and regulates intracellular membrane trafficking pathways in vertebrate cells. RAB39A interacts with various molecules and modulates vesicular trafficking that regulates multiple biological pathways such as neuronal differentiation and/or autophagy. Among these pathways are Hippo and Notch signalings, microtubular organization, and mitophagy/autophagy. Although RAB39A has never been studied in cancer biology, it has been recently shown to promote cancer stemness and tumorigenesis...
April 10, 2018: Journal of Biochemistry
https://www.readbyqxmd.com/read/29627454/expression-patterns-of-yes-associated-protein-1-in-the-developing-mouse-liver
#6
Wei Wei, Jeremy Lotto, Pamela A Hoodless
The Hippo signalling pathway regulates many cellular processes, but has been specifically associated with control organ size and tumor growth. Yes-associated protein 1 (YAP1) is a transcriptional cofactor, in the Hippo pathway, that regulates gene expression when localized in the nucleus. Elevated expression of YAP1 in adult mouse liver leads to hepatomegaly and can cause hepatocellular carcinoma; while the loss of function studies reveal its importance in regulating cholangiocyte development. Here, we report the expression of YAP1 in mouse embryonic and postnatal hepatic cells, using AFP-GFP transgenic mice to identify the hepatocyte lineage...
April 5, 2018: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/29625050/oncogenic-signaling-pathways-in-the-cancer-genome-atlas
#7
Francisco Sanchez-Vega, Marco Mina, Joshua Armenia, Walid K Chatila, Augustin Luna, Konnor C La, Sofia Dimitriadoy, David L Liu, Havish S Kantheti, Sadegh Saghafinia, Debyani Chakravarty, Foysal Daian, Qingsong Gao, Matthew H Bailey, Wen-Wei Liang, Steven M Foltz, Ilya Shmulevich, Li Ding, Zachary Heins, Angelica Ochoa, Benjamin Gross, Jianjiong Gao, Hongxin Zhang, Ritika Kundra, Cyriac Kandoth, Istemi Bahceci, Leonard Dervishi, Ugur Dogrusoz, Wanding Zhou, Hui Shen, Peter W Laird, Gregory P Way, Casey S Greene, Han Liang, Yonghong Xiao, Chen Wang, Antonio Iavarone, Alice H Berger, Trever G Bivona, Alexander J Lazar, Gary D Hammer, Thomas Giordano, Lawrence N Kwong, Grant McArthur, Chenfei Huang, Aaron D Tward, Mitchell J Frederick, Frank McCormick, Matthew Meyerson, Eliezer M Van Allen, Andrew D Cherniack, Giovanni Ciriello, Chris Sander, Nikolaus Schultz
Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterations in these pathways differ between individual tumors and tumor types. Using mutations, copy-number changes, mRNA expression, gene fusions and DNA methylation in 9,125 tumors profiled by The Cancer Genome Atlas (TCGA), we analyzed the mechanisms and patterns of somatic alterations in ten canonical pathways: cell cycle, Hippo, Myc, Notch, Nrf2, PI-3-Kinase/Akt, RTK-RAS, TGFβ signaling, p53 and β-catenin/Wnt...
April 5, 2018: Cell
https://www.readbyqxmd.com/read/29604130/structural-basis-for-tankyrase-rnf146-interaction-reveals-noncanonical-tankyrase-binding-motifs
#8
Paul A DaRosa, Rachel E Klevit, Wenqing Xu
Poly(ADP-ribosyl)ation (PARylation) catalyzed by the tankyrase enzymes (Tankyrase-1 and -2; a.k.a. PARP-5a and -5b) is involved in mitosis, telomere length regulation, GLUT-4 vesicle transport, and cell growth and differentiation. Together with the E3 ubiquitin ligase RNF146 (a.k.a. Iduna), tankyrases regulate the cellular concentrations of several important proteins including Axin, 3BP2, and angiomotins, which are key regulators of Wnt, Src and hippo signaling, respectively. These substrates of tankyrases are first PARylated and then ubiquitylated by RNF146, which is allosterically activated by binding to PAR polymer...
March 31, 2018: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29602952/regulation-of-the-hippo-pathway-in-cancer-biology
#9
REVIEW
Sungho Moon, So Yeon Park, Hyun Woo Park
The Hippo tumor suppressor pathway, which is well conserved from Drosophila to humans, has emerged as the master regulator of organ size, as well as major cellular properties, such as cell proliferation, survival, stemness, and tissue homeostasis. The biological significance and deregulation of the Hippo pathway in tumorigenesis have received a surge of interest in the past decade. In the current review, we present the major discoveries that made substantial contributions to our understanding of the Hippo pathway and discuss how Hippo pathway components contribute to cellular signaling, physiology, and their potential implications in anticancer therapeutics...
March 30, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29602800/the-microrna-200-family-coordinately-regulates-cell-adhesion-and-proliferation-in-hair-morphogenesis
#10
Jaimee E Hoefert, Glen A Bjerke, Dongmei Wang, Rui Yi
The microRNA (miRNA)-200 (miR-200) family is highly expressed in epithelial cells and frequently lost in metastatic cancer. Despite intensive studies into their roles in cancer, their targets and functions in normal epithelial tissues remain unclear. Importantly, it remains unclear how the two subfamilies of the five-miRNA family, distinguished by a single nucleotide within the seed region, regulate their targets. By directly ligating miRNAs to their targeted mRNA regions, we identify numerous miR-200 targets involved in the regulation of focal adhesion, actin cytoskeleton, cell cycle, and Hippo/Yap signaling...
March 30, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/29597279/the-hippo-pathway-immunity-and-cancer
#11
REVIEW
Zaid Taha, Helena J Janse van Rensburg, Xiaolong Yang
Since its discovery, the Hippo pathway has emerged as a central signaling network in mammalian cells. Canonical signaling through the Hippo pathway core components (MST1/2, LATS1/2, YAP and TAZ) is important for development and tissue homeostasis while aberrant signaling through the Hippo pathway has been implicated in multiple pathologies, including cancer. Recent studies have uncovered new roles for the Hippo pathway in immunology. In this review, we summarize the mechanisms by which Hippo signaling in pathogen-infected or neoplastic cells affects the activities of immune cells that respond to these threats...
March 28, 2018: Cancers
https://www.readbyqxmd.com/read/29594150/mechanotransduction-in-coronary-vein-graft-disease
#12
Matthijs Steven Ruiter, Maurizio Pesce
Autologous saphenous veins are the most commonly used conduits in revascularization of the ischemic heart by coronary artery bypass graft surgery, but are subject to vein graft failure. The current mini review aims to provide an overview of the role of mechanotransduction signalling underlying vein graft failure to further our understanding of the disease progression and to improve future clinical treatment. Firstly, limitation of damage during vein harvest and engraftment can improve outcome. In addition, cell cycle inhibition, stimulation of Nur77 and external grafting could form interesting therapeutic options...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29593499/mob2-insufficiency-disrupts-neuronal-migration-in-the-developing-cortex
#13
Adam C O'Neill, Christina Kyrousi, Melanie Einsiedler, Ingo Burtscher, Micha Drukker, David M Markie, Edwin P Kirk, Magdalena Götz, Stephen P Robertson, Silvia Cappello
Disorders of neuronal mispositioning during brain development are phenotypically heterogeneous and their genetic causes remain largely unknown. Here, we report biallelic variants in a Hippo signaling factor- MOB2 -in a patient with one such disorder, periventricular nodular heterotopia (PH). Genetic and cellular analysis of both variants confirmed them to be loss-of-function with enhanced sensitivity to transcript degradation via nonsense mediated decay (NMD) or increased protein turnover via the proteasome...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29589535/signaling-pathways-in-inflammation-and-anti-inflammatory-therapies
#14
Yiu To Yeung, Faisal Aziz, Angelica Guerrero-Castilla, Sandro Arguelles
During the past decade, an abundance of new evidence highlighted the importance of inflammation in the development of chronic pathologies such as neurodegeneration, cancer, diabetes, cardiovascular disease and inflammatory bowel disease. However, most of the current therapies do not address the underlying problem and better therapies are urgently needed. A growing number of researchers have discovered various signaling pathways that are associated with the initiation and progression of inflammation. Among different pathways, we will focus on three classical inflammatory pathways: p38 MAPK, IL-6/JAK/STAT3 and PI3K; and a non-classical inflammatory pathway, the Hippo...
March 27, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29587439/nf2-merlin-inactivation-and-potential-therapeutic-targets-in-mesothelioma
#15
REVIEW
Tatsuhiro Sato, Yoshitaka Sekido
The neurofibromatosis type 2 ( NF2 ) gene encodes merlin, a tumor suppressor protein frequently inactivated in schwannoma, meningioma, and malignant mesothelioma (MM). The sequence of merlin is similar to that of ezrin/radixin/moesin (ERM) proteins which crosslink actin with the plasma membrane, suggesting that merlin plays a role in transducing extracellular signals to the actin cytoskeleton. Merlin adopts a distinct closed conformation defined by specific intramolecular interactions and regulates diverse cellular events such as transcription, translation, ubiquitination, and miRNA biosynthesis, many of which are mediated through Hippo and mTOR signaling, which are known to be closely involved in cancer development...
March 26, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29577047/how-hippo-signaling-pathway-modulates-cardiovascular-development-and-diseases
#16
REVIEW
Wenyi Zhou, Mingyi Zhao
Cardiovascular disease remains the leading cause of death around the globe. Cardiac deterioration is associated with irreversible cardiomyocyte loss. Understanding how the cardiovascular system develops and the pathological processes of cardiac disease will contribute to finding novel and preventive therapeutic methods. The canonical Hippo tumor suppressor pathway in mammalian cells is primarily composed of the MST1/2-SAV1-LATS1/2-MOB1-YAP/TAZ cascade. Continuing research on this pathway has identified other factors like RASSF1A, Nf2, MAP4Ks, and NDR1/2, further enriching our knowledge of the Hippo-YAP pathway...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29575535/inhibition-of-yes-associated-protein-down-regulates-pd-l1-cd274-expression-in-human-malignant-pleural-mesothelioma
#17
Ping-Chih Hsu, Jinbai Miao, Yu-Cheng Wang, Wen-Qian Zhang, Yi-Lin Yang, Chih-Wei Wang, Cheng-Ta Yang, Zhen Huang, Joanna You, Zhidong Xu, David M Jablons, Liang You
Although tumour PD-L1 (CD274) expression had been used as a predictive biomarker in checkpoint immunotherapy targeting the PD1/PD-L1 axis in various cancers, the regulation of PD-L1 (CD274) expression is unclear. Yes-associated protein (YAP), an important oncogenic protein in Hippo signalling pathway, reportedly promotes cancer development. We investigated whether inhibition of YAP down-regulates PD-L1 (CD274) in human malignant pleural mesothelioma (MPM). Western blotting showed that 2 human MPM cell lines (H2052 and 211H) had increased PD-L1 protein expression compared to H290, MS-1 and H28 cells...
March 24, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29571247/comprehensive-analysis-and-experimental-verification-of-linc01314-as-a-tumor-suppressor-in-hepatoblastoma
#18
Benji Lv, Lianhai Zhang, Runchen Miao, Xiaohong Xiang, Shunbin Dong, Ting Lin, Ke Li, Qu Kai
Hepatoblastoma (HB), as a common pediatric liver malignancy, is composed of a variety of subgroups with different clinical outcomes. Long-noncoding RNA (lncRNA) has crucial roles in cancer biology. However, the association between lncRNA and HB has not been fully investigated. In this study, we screened lncRNA expression profiles that were annotated from the GSE75271 dataset. A total of 225 differentially expressed lncRNAs (DELs) were identified based on comparison between three prognostic subgroups, and seven of them (XR_241302, XR_923061, NR_038322, XR_951687, XR_934593, NR_120317 and XR_93406) that exhibited highly predictive accuracies were selected for functional analysis...
February 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29568120/role-of-hippo-signaling-in-regulating-immunity
#19
REVIEW
Lixin Hong, Xun Li, Dawang Zhou, Jing Geng, Lanfen Chen
The Hippo signaling pathway has been established as a key regulator of organ size control, tumor suppression, and tissue regeneration in multiple organisms. Recently, emerging evidence has indicated that Hippo signaling might play an important role in regulating the immune system in both Drosophila and mammals. In particular, patients bearing a loss-of-function mutation of MST1 are reported to have an autosomal recessive primary immunodeficiency syndrome. MST1/2 kinases, the mammalian orthologs of Drosophila Hippo, may activate the non-canonical Hippo signaling pathway via MOB1A/B and/or NDR1/2 or cross-talk with other essential signaling pathways to regulate both innate and adaptive immunity...
March 22, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29565815/targeting-the-hippo-pathway-is-a-new-potential-therapeutic-modality-for-malignant-mesothelioma
#20
REVIEW
Yoshitaka Sekido
Malignant mesothelioma (MM) constitutes a very aggressive tumor that arises from the pleural or peritoneal cavities and is highly refractory to conventional therapies. Several key genetic alterations are associated with the development and progression of MM including mutations of the CDKN2A/ARF , NF2 , and BAP1 tumor-suppressor genes. Notably, activating oncogene mutations are very rare; thus, it is difficult to develop effective inhibitors to treat MM. The NF2 gene encodes merlin, a protein that regulates multiple cell-signaling cascades including the Hippo pathway...
March 22, 2018: Cancers
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