keyword
https://read.qxmd.com/read/38535186/stripak-dependent-and-independent-phosphorylation-of-the-sin-kinase-dbf2-controls-fruiting-body-development-and-cytokinesis-during-septation-and-ascospore-formation-in-sordaria-macrospora
#1
JOURNAL ARTICLE
Maria Shariatnasery, Valentina Stein, Ines Teichert, Ulrich Kück
The supramolecular striatin-interacting phosphatases and kinases (STRIPAK) complex is highly conserved in eukaryotes and controls diverse developmental processes in fungi. STRIPAK is genetically and physically linked to the Hippo-related septation initiation network (SIN), which signals through a chain of three kinases, including the terminal nuclear Dbf2-related (NDR) family kinase DBF2. Here, we provide evidence for the function of DBF2 during sexual development and vegetative growth of the homothallic ascomycetous model fungus Sordaria macrospora ...
February 26, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38531200/ischemia-inhibited-ferric-chelate-reductase-1-improves-ferroptosis-mediated-intestinal-ischemia-injury-via-hippo-signaling
#2
JOURNAL ARTICLE
Pengzhen Liang, Wei Xie, Xing Wang, Zhaohui Du, Chuanming Zheng, Hongchang Zhao, Zhenjie Wang, Zhong Ji
The precise mechanism of ferroptosis as a regulatory cell death in intestinal ischemia injury induced by vascular intestinal obstruction (Vio) remains to be elucidated. Here, we evaluated iron levels, glutathione peroxidase 4 (GPX4) and Acyl-CoA synthetase long-chain family member 4 (ACSL4) changes after intestinal ischemia injury to validate ferroptosis. As an enzyme for Fe3+ reduction to Fe2+ , Ferric Chelate Reductase 1 (FRRS1) is involved in the electron transport chain and the tricarboxylic acid (TCA) cycle in mitochondria...
March 25, 2024: International Immunopharmacology
https://read.qxmd.com/read/38529510/hippo-deficient-cardiac-fibroblasts-differentiate-into-osteochondroprogenitors
#3
Chang-Ru Tsai, Jong Kim, Xiao Li, Paulo Czarnewski, Rich Li, Fansen Meng, Mingjie Zheng, Xiaolei Zhao, Jeffrey Steimle, Francisco Grisanti, Jun Wang, Md Abul Hassan Samee, James Martin
Cardiac fibrosis, a common pathophysiology associated with various heart diseases, occurs from the excess deposition of extracellular matrix (ECM) 1 . Cardiac fibroblasts (CFs) are the primary cells that produce, degrade, and remodel ECM during homeostasis and tissue repair 2 . Upon injury, CFs gain plasticity to differentiate into myofibroblasts 3 and adipocyte-like 4,5 and osteoblast-like 6 cells, promoting fibrosis and impairing heart function 7 . How CFs maintain their cell state during homeostasis and adapt plasticity upon injury are not well defined...
September 8, 2023: bioRxiv
https://read.qxmd.com/read/38527062/hippo-signaling-controlled-mhc-class-i-antigen-processing-and-presentation-pathway-potentiates-antitumor-immunity
#4
JOURNAL ARTICLE
Linyuan Peng, Liang Zhou, Huan Li, Xin Zhang, Su Li, Kai Wang, Mei Yang, Xiaoyu Ma, Danlan Zhang, Siliang Xiang, Yajun Duan, Tianzhi Wang, Chunmeng Sun, Chen Wang, Desheng Lu, Minxian Qian, Zhongyuan Wang
The major histocompatibility complex class I (MHC class I)-mediated tumor antigen processing and presentation (APP) pathway is essential for the recruitment and activation of cytotoxic CD8+ T lymphocytes (CD8+ CTLs). However, this pathway is frequently dysregulated in many cancers, thus leading to a failure of immunotherapy. Here, we report that activation of the tumor-intrinsic Hippo pathway positively correlates with the expression of MHC class I APP genes and the abundance of CD8+ CTLs in mouse tumors and patients...
March 23, 2024: Cell Reports
https://read.qxmd.com/read/38522513/the-tumor-suppressor-nf2-modulates-tead4-stability-and-activity-in-hippo-signaling-via-direct-interaction
#5
JOURNAL ARTICLE
Mengying Wu, Liqiao Hu, Lingli He, Liang Yuan, Lingling Yang, Bin Zhao, Lei Zhang, Xiaojing He
As an output effector of the Hippo signaling pathway, the TEAD transcription factor and co-activator YAP play crucial functions in promoting cell proliferation and organ size. The tumor suppressor NF2 has been shown to activate LATS1/2 kinases and interplay with the Hippo pathway to suppress the YAP-TEAD complex. However, whether and how NF2 could directly regulate TEAD remains unknown. We identified a direct link and physical interaction between NF2 and TEAD4. NF2 interacted with TEAD4 through its FERM domain and C-terminal tail and decreased the protein stability of TEAD4 independently of LATS1/2 and YAP...
March 22, 2024: Journal of Biological Chemistry
https://read.qxmd.com/read/38521502/upregulation-of-cyr61-by-tgf-%C3%AE-and-yap-signaling-exerts-a-counter-suppression-of-hepatocellular-carcinoma
#6
JOURNAL ARTICLE
Cheng Zhang, Wenjing Wei, Shuo Tu, Bo Liang, Chun Li, Yining Li, Weicheng Luo, Yiqing Wu, Xiaohui Dai, Yi Wang, Lijuan Zheng, Liang Hao, Chunbo Zhang, Zhijun Luo, Ye-Guang Chen, Xiaohua Yan
TGF-β and Hippo signaling are two critical pathways engaged in cancer progression by regulating both oncogenes and tumor suppressors, yet how the two pathways coordinately exert their functions in the development of hepatocellular carcinoma (HCC) remains elusive. In this study, we firstly conducted an integrated analysis of public liver cancer databases and our experimental TGF-β target genes, identifying CYR61 as a pivotal candidate gene relating to HCC development. The expression of CYR61 is downregulated in clinical HCC tissues and cell lines than that in the normal counterparts...
March 21, 2024: Journal of Biological Chemistry
https://read.qxmd.com/read/38517944/the-hippo-kinase-cascade-regulates-a-contractile-cell-behavior-and-cell-density-in-a-close-unicellular-relative-of-animals
#7
JOURNAL ARTICLE
Jonathan E Phillips, Duojia Pan
The genomes of close unicellular relatives of animals encode orthologs of many genes that regulate animal development. However, little is known about the function of such genes in unicellular organisms or the evolutionary process by which these genes came to function in multicellular development. The Hippo pathway, which regulates cell proliferation and tissue size in animals, is present in some of the closest unicellular relatives of animals, including the amoeboid organism Capsaspora owczarzaki . We previously showed that the Capsaspora ortholog of the Hippo pathway nuclear effector Yorkie/YAP/TAZ (coYki) regulates actin dynamics and the three-dimensional morphology of Capsaspora cell aggregates, but is dispensable for cell proliferation control (Phillips et al...
March 22, 2024: ELife
https://read.qxmd.com/read/38517039/eno1-contributes-to-the-gemcitabine-resistance-of-pancreatic-cancer-through-the-yap1-signaling-pathway
#8
JOURNAL ARTICLE
Hongqin Ma, Lulu Kong, Li Liu, Yusheng Du, Xinguo Zhu, Ji Wang, Wenxing Zhao
Pancreatic cancer (PC), a leading cause of cancer-related deaths, has a 5-year survival rate of approximately 10%. α-Enolase (ENO1) is a junction channel protein involved in tumor cell apoptosis and chemoresistance. However, the role of ENO1 in PC remains unclear. The expression and prognosis of ENO1 levels were determined in PC using public databases based on The Cancer Genome Atlas (TCGA) data sets. Cell viability, half maximal inhibitory concentration (IC50), autophagy, apoptosis, and autophagy markers were examined using cell counting kit-8 (CCK-8), transmission electron microscope, flow cytometry assays, and immunoblot, respectively...
March 22, 2024: Molecular Carcinogenesis
https://read.qxmd.com/read/38516191/emerging-roles-of-long-non-coding-rnas-in-osteosarcoma
#9
REVIEW
Xun Liao, Rong Wei, Junxiu Zhou, Ke Wu, Jiao Li
Osteosarcoma (OS) is a highly aggressive and lethal malignant bone tumor that primarily afflicts children, adolescents, and young adults. However, the molecular mechanisms underlying OS pathogenesis remain obscure. Mounting evidence implicates dysregulated long non-coding RNAs (lncRNAs) in tumorigenesis and progression. These lncRNAs play a pivotal role in modulating gene expression at diverse epigenetic, transcriptional, and post-transcriptional levels. Uncovering the roles of aberrant lncRNAs would provide new insights into OS pathogenesis and novel tools for its early diagnosis and treatment...
2024: Frontiers in Molecular Biosciences
https://read.qxmd.com/read/38514720/the-immune-regulation-and-therapeutic-potential-of-the-smad-gene-family-in-breast-cancer
#10
JOURNAL ARTICLE
Zhuo Chen, Yu Wang, Xiaodi Lu, Hong Chen, Yiran Kong, Liwei Rong, Guonian Wang
Breast cancer is a serious threat to human health. The transforming growth factor-β signaling pathway is an important pathway involved in the occurrence and development of cancer. The SMAD family genes are responsible for the TGF-β signaling pathway. However, the mechanism by which genes of the SMAD family are involved in breast cancer is still unclear. Therefore, it is necessary to investigate the biological roles of the SMAD family genes in breast cancer. We downloaded the gene expression data, gene mutation data, and clinical pathological data of breast cancer patients from the UCSC Xena database...
March 21, 2024: Scientific Reports
https://read.qxmd.com/read/38514682/human-dental-pulp-stem-cells-derived-extracellular-matrix-promotes-mineralization-via-hippo-and-wnt-pathways
#11
JOURNAL ARTICLE
Chatvadee Kornsuthisopon, Nunthawan Nowwarote, Ajjima Chansaenroj, Suphalak Photichailert, Sunisa Rochanavibhata, Nuttha Klincumhom, Stephane Petit, Florent Dingli, Damarys Loew, Benjamin P J Fournier, Thanaphum Osathanon
Extracellular matrix (ECM) is an intricate structure providing the microenvironment niche that influences stem cell differentiation. This study aimed to investigate the efficacy of decellularized ECM derived from human dental pulp stem cells (dECM_DPSCs) and gingival-derived mesenchymal stem cells (dECM_GSCs) as an inductive scaffold for osteogenic differentiation of GSCs. The proteomic analysis demonstrated that common and signature matrisome proteins from dECM_DPSCs and dECM_GSCs were related to osteogenesis/osteogenic differentiation...
March 21, 2024: Scientific Reports
https://read.qxmd.com/read/38512451/the-alanyl-trna-synthetase-aars1-moonlights-as-a-lactyl-transferase-to-promote-yap-signaling-in-gastric-cancer
#12
JOURNAL ARTICLE
Junyi Ju, Hui Zhang, Moubin Lin, Zifeng Yan, Liwei An, Zhifa Cao, Dandan Geng, Jingwu Yue, Yang Tang, Luyang Tian, Fan Chen, Yi Han, Wenjia Wang, Shimin Zhao, Jiao Shi, Zhaocai Zhou
Lactylation has been recently identified as a new type of posttranslational modification widely occurring on lysine residues of both histone and non-histone proteins. The acetyl transferase p300 is thought to mediate protein lactylation, yet the cellular concentration of the proposed lactyl-donor, lactyl-coenzyme A is about 1,000 times lower than that of acetyl-CoA, raising the question whether p300 is a genuine lactyl-transferase. Here, we report the Alanyl-tRNA synthetase 1 (AARS1) moonlights as a bona fide lactyl-transferase that directly uses lactate and ATP to catalyze protein lactylation...
March 21, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/38510108/yap-induces-a-neonatal-like-pro-renewal-niche-in-the-adult-heart
#13
JOURNAL ARTICLE
Rich Gang Li, Xiao Li, Yuka Morikawa, Francisco J Grisanti-Canozo, Fansen Meng, Chang-Ru Tsai, Yi Zhao, Lin Liu, Jong Kim, Bing Xie, Elzbieta Klysik, Shijie Liu, Md Abul Hassan Samee, James F Martin
After myocardial infarction (MI), mammalian hearts do not regenerate, and the microenvironment is disrupted. Hippo signaling loss of function with activation of transcriptional co-factor YAP induces heart renewal and rebuilds the post-MI microenvironment. In this study, we investigated adult renewal-competent mouse hearts expressing an active version of YAP, called YAP5SA, in cardiomyocytes (CMs). Spatial transcriptomics and single-cell RNA sequencing revealed a conserved, renewal-competent CM cell state called adult (a)CM2 with high YAP activity...
March 2024: Nat Cardiovasc Res
https://read.qxmd.com/read/38509842/jcad-deficiency-delayed-liver-regenerative-repair-through-the-hippo-yap-signalling-pathway
#14
JOURNAL ARTICLE
Li Zhang, Yong-Yu Yang, Li Xie, Yuan Zhou, Zhenxing Zhong, Jia Ding, Zhong-Hua Wang, Yu-Li Wang, Xiu-Ping Liu, Fa-Xing Yu, Jian Wu
BACKGROUND AND AIMS: Liver regeneration retardation post partial hepatectomy (PH) is a common clinical problem after liver transplantation. Identification of key regulators in liver regeneration post PH may be beneficial for clinically improving the prognosis of patients after liver transplantation. This study aimed to clarify the function of junctional protein-associated with coronary artery disease (JCAD) in liver regeneration post PH and to reveal the underlying mechanisms. METHODS: JCAD knockout (JCAD-KO), liver-specific JCAD-KO (Jcad△Hep ) mice and their control group were subjected to 70% PH...
March 2024: Clinical and Translational Medicine
https://read.qxmd.com/read/38506089/retinoic-acid-induced-specific-changes-in-the-phosphoproteome-of-c17-2-neural-stem-cells
#15
JOURNAL ARTICLE
Cheng Zhang, Lite Ge, Huali Xie, Xiaoqian Liu, Chengfeng Xun, Yan Chen, Haiyan Chen, Ming Lu, Ping Chen
Retinoic acid (RA), a vitamin A derivative, is an effective cell differentiating factor which plays critical roles in neuronal differentiation induction and the production of neurotransmitters in neurons. However, the specific changes in phosphorylation levels and downstream signalling pathways associated with RA remain unclear. This study employed qualitative and quantitative phosphoproteomics approaches based on mass spectrometry to investigate the phosphorylation changes induced by RA in C17.2 neural stem cells (NSCs)...
April 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38504123/human-cytomegalovirus-cmv-dysregulates-neurodevelopmental-pathways-in-cerebral-organoids
#16
JOURNAL ARTICLE
Ece Egilmezer, Stuart T Hamilton, Charles S P Foster, Manfred Marschall, William D Rawlinson
Human cytomegalovirus (CMV) infection is the leading non-genetic aetiology of congenital malformation in developed countries, causing significant fetal neurological injury. This study investigated potential CMV pathogenetic mechanisms of fetal neural malformation using in vitro human cerebral organoids. Cerebral organoids were permissive to CMV replication, and infection dysregulated cellular pluripotency and differentiation pathways. Aberrant expression of dual-specificity tyrosine phosphorylation-regulated kinases (DYRK), sonic hedgehog (SHH), pluripotency, neurodegeneration, axon guidance, hippo signalling and dopaminergic synapse pathways were observed in CMV-infected organoids using immunofluorescence and RNA-sequencing...
March 19, 2024: Communications Biology
https://read.qxmd.com/read/38502585/yap-taz-as-molecular-targets-in-skeletal-muscle-atrophy-and-osteoporosis
#17
REVIEW
Youngjoo Kwon
Skeletal muscles and bones are closely connected anatomically and functionally. Age-related degeneration in these tissues is associated with physical disability in the elderly and significantly impacts their quality of life. Understanding the mechanisms of age-related musculoskeletal tissue degeneration is crucial for identifying molecular targets for therapeutic interventions for skeletal muscle atrophy and osteoporosis. The Hippo pathway is a recently identified signaling pathway that plays critical roles in development, tissue homeostasis, and regeneration...
March 14, 2024: Aging and Disease
https://read.qxmd.com/read/38499647/hippo-pathway-in-non-small-cell-lung-cancer-mechanisms-potential-targets-and-biomarkers
#18
REVIEW
Hongge Liang, Yan Xu, Jing Zhao, Minjiang Chen, Mengzhao Wang
Lung cancer is the primary contributor to cancer-related deaths globally, and non-small cell lung cancer (NSCLC) constitutes around 85% of all lung cancer cases. Recently, the emergence of targeted therapy and immunotherapy revolutionized the treatment of NSCLC and greatly improved patients' survival. However, drug resistance is inevitable, and extensive research has demonstrated that the Hippo pathway plays a crucial role in the development of drug resistance in NSCLC. The Hippo pathway is a highly conserved signaling pathway that is essential for various biological processes, including organ development, maintenance of epithelial balance, tissue regeneration, wound healing, and immune regulation...
March 18, 2024: Cancer Gene Therapy
https://read.qxmd.com/read/38499286/reversal-of-cisplatin-resistance-in-oral-squamous-cell-carcinoma-by-piperlongumine-loaded-smart-nanoparticles-through-inhibition-of-hippo-yap-signaling-pathway
#19
JOURNAL ARTICLE
Pratikshya Sa, Priya Singh, Sudhakar Panda, Rajeeb K Swain, Rupesh Dash, Sanjeeb Kumar Sahoo
Cisplatin alone or in combination with 5FU and docetaxel is the preferred chemotherapy regimen for advanced-stage OSCC patients. However, its use has been linked to recurrence and metastasis due to the development of drug resistance. Therefore, sensitization of cancer cells to conventional chemotherapeutics can be an effective strategy to overcome drug resistance. Piperlongumine, an alkaloid, have shown anticancer properties and sensitizes numerous neoplasms, but its effect on OSCC has not been explored. However, low aqueous solubility and poor pharmacokinetics limit its clinical application...
March 16, 2024: Translational Research: the Journal of Laboratory and Clinical Medicine
https://read.qxmd.com/read/38496413/hpv18-e7-inhibits-lats1-kinase-and-activates-yap1-by-degrading-ptpn14
#20
William J Blakely, Joshua Hatterschide, Elizabeth A White
UNLABELLED: High-risk human papillomavirus (HPV) oncoproteins inactivate cellular tumor suppressors to reprogram host cell signaling pathways. HPV E7 proteins bind and degrade the tumor suppressor PTPN14, thereby promoting the nuclear localization of the YAP1 oncoprotein and inhibiting keratinocyte differentiation. YAP1 is a transcriptional coactivator that drives epithelial cell stemness and self-renewal. YAP1 activity is inhibited by the highly conserved Hippo pathway, which is frequently inactivated in human cancers...
March 7, 2024: bioRxiv
keyword
keyword
95639
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.