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https://www.readbyqxmd.com/read/27903890/pharos-collating-protein-information-to-shed-light-on-the-druggable-genome
#1
Dac-Trung Nguyen, Stephen Mathias, Cristian Bologa, Soren Brunak, Nicolas Fernandez, Anna Gaulton, Anne Hersey, Jayme Holmes, Lars Juhl Jensen, Anneli Karlsson, Guixia Liu, Avi Ma'ayan, Geetha Mandava, Subramani Mani, Saurabh Mehta, John Overington, Juhee Patel, Andrew D Rouillard, Stephan Schürer, Timothy Sheils, Anton Simeonov, Larry A Sklar, Noel Southall, Oleg Ursu, Dusica Vidovic, Anna Waller, Jeremy Yang, Ajit Jadhav, Tudor I Oprea, Rajarshi Guha
The 'druggable genome' encompasses several protein families, but only a subset of targets within them have attracted significant research attention and thus have information about them publicly available. The Illuminating the Druggable Genome (IDG) program was initiated in 2014, has the goal of developing experimental techniques and a Knowledge Management Center (KMC) that would collect and organize information about protein targets from four families, representing the most common druggable targets with an emphasis on understudied proteins...
November 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27885658/early-skin-to-skin-contact-for-mothers-and-their-healthy-newborn-infants
#2
REVIEW
Elizabeth R Moore, Nils Bergman, Gene C Anderson, Nancy Medley
BACKGROUND: Mother-infant separation post birth is common. In standard hospital care, newborn infants are held wrapped or dressed in their mother's arms, placed in open cribs or under radiant warmers. Skin-to-skin contact (SSC) begins ideally at birth and should last continually until the end of the first breastfeeding. SSC involves placing the dried, naked baby prone on the mother's bare chest, often covered with a warm blanket. According to mammalian neuroscience, the intimate contact inherent in this place (habitat) evokes neuro-behaviors ensuring fulfillment of basic biological needs...
November 25, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27822298/towards-emic-rational-design-setting-the-molecular-simulation-toolbox-for-enantiopure-molecularly-imprinted-catalysts
#3
REVIEW
Tessa Jalink, Tom Farrand, Carmelo Herdes
A critical appraisal of the current strategies for the synthesis of enantiopure drugs is presented, along with a systematic background for the computational design of stereoselective porous polymers. These materials aim to achieve the enantiomeric excess of any chiral drug, avoiding the racemic separation. Particular emphasis is given to link statistical mechanics methods to the description of each one of the experimental stages within the catalyst's synthesis, setting a framework for the fundamental study of the emerging field of molecularly imprinted catalysts...
2016: Chemistry Central Journal
https://www.readbyqxmd.com/read/27800071/neonatal-transport-practices-in-ibadan-nigeria
#4
Muhydeen Abiodun Abdulraheem, Olukemi Oluwatoyin Tongo, Adebola Emmanuel Orimadegun, Olukayode Felix Akinbami
INTRODUCTION: Neonatal transport involves moving sick neonates in optimal conditions to ensure good outcomes. It is well organized in most developed countries but receives little attention in developing countries where the highest burden of neonatal mortality exists and a large number of newborns require referrals daily for better medical care. This study sought to evaluate the modes of transport, pre- and intra-transport care of neonates referred to the University College Hospital (UCH), Ibadan, Nigeria...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27765653/the-kangaroo-mother-care-method-from-scientific-evidence-generated-in-colombia-to-worldwide-practice
#5
Nathalie Charpak, Juan Gabriel Ruiz
Kangaroo Mother Care (KMC) is a human-based care intervention devised to complement neonatal care for low birth weight and premature infants. Kangaroo position (skin-to-skin contact on the mother's chest) offers thermal regulation, physiological stability, appropriate stimulation and enhances bonding and breastfeeding. Kangaroo nutrition is based on breastfeeding and kangaroo discharge policy relies on family empowerment and early discharge in kangaroo position with close ambulatory follow-up. We describe how the evidence has been developed, and how it has been put into practice by means of direct preterm infants care and dissemination of the method, including training of KMC excellence centers in many countries not only in Latin America but worldwide...
October 17, 2016: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/27743146/live-weight-conformation-carcass-traits-and-economic-values-of-ram-lambs-of-red-maasai-and-dorper-sheep-and-their-crosses
#6
E Zonabend König, J M K Ojango, J Audho, T Mirkena, E Strandberg, A M Okeyo, J Philipsson
Meat production is the most important trait in the breeding objectives of sheep production in East Africa. The aim of this study was to investigate breed differences in live weight, conformation, carcass traits and economic values for meat production among Red Maasai and Dorper sheep and their crosses. In total, 88 ram lambs, which were reared at the ILRI experimental station, Kapiti plains Estate in Central Kenya, were used for the study. The lambs were slaughtered at Kenya Meat Commission (KMC) at about 1 year of age...
October 14, 2016: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/27627386/microscopic-modeling-of-confined-crystal-growth-and-dissolution
#7
Jørgen Høgberget, Anja Røyne, Dag K Dysthe, Espen Jettestuen
We extend the (1+1)-dimensional fluid solid-on-solid (SOS) model to include a confining flat surface opposite to the SOS surface subject to a constant load. This load is balanced by a repulsive surface-surface interaction given by an ansatz which agrees with known analytical solutions in the limit of two separated flat surfaces. Mechanical equilibrium is imposed at all times by repositioning the confining surface. By the use of kinetic Monte Carlo (KMC) we calculate how the equilibrium concentration (deposition rate) depends on the applied load, and find it to reproduce analytical thermodynamics independent of the parameters of the interaction ansatz...
August 2016: Physical Review. E
https://www.readbyqxmd.com/read/27580070/surface-chemical-tuning-of-phonon-and-electron-transport-in-free-standing-silicon-nanowire-arrays
#8
Ying Pan, Ye Tao, Guangzhao Qin, Yuriy Fedoryshyn, Shyamprasad N Raja, Ming Hu, Christian L Degen, Dimos Poulikakos
We report electronic and phononic transport measurements of monocrystalline batch-fabricated silicon nanowire (SiNW) arrays functionalized with different surface chemistries. We find that hydrogen-terminated SiNWs prepared by vapor HF etching of native-oxide-covered devices show increased electrical conductivity but decreased thermal conductivity. We used the kinetic Monte Carlo method to solve the Boltzmann transport equation and also numerically examine the effect of phonon boundary scattering. Surface transfer doping of the SiNWs by cobaltocene or decamethylcobaltocene drastically improves the electrical conductivity by 2 to 4 orders of magnitude without affecting the thermal conductivity...
October 12, 2016: Nano Letters
https://www.readbyqxmd.com/read/27579255/an-assessment-of-maternal-newborn-and-child-health-implementation-studies-in-nigeria-implications-for-evidence-informed-policymaking-and-practice
#9
REVIEW
Chigozie Jesse Uneke, Issiaka Sombie, Namoudou Keita, Virgil Lokossou, Ermel Johnson, Pierre Ongolo-Zogo
BACKGROUND: The introduction of implementation science into maternal, newborn and child health (MNCH) research has facilitated better methods to improve uptake of research findings into practices. With increase in implementation research related to MNCH world-wide, stronger scientific evidence are now available and have improved MNCH policies in many countries including Nigeria. The purpose of this study was to review MNCH implementation studies undertaken in Nigeria in order to understand the extent the evidence generated informed better policy...
2016: Health Promotion Perspectives
https://www.readbyqxmd.com/read/27573363/in-vitro-digestion-and-absorption-of-bde-28-47-99-and-153-in-indoor-dust-and-its-implication-in-risk-assessment
#10
Yuan Kang, Weijian Pan, Siyun Liang, Lixuan Zeng, Qiuyun Zhang, Jiwen Luo, Xinmei Guo
The bioaccessibility of polybrominated diphenyl ethers (PBDEs) in indoor dust was estimated by a series of in vitro digestion methods. However, the absorption of PBDEs by intestinal cells after in vitro digestion was seldom studied. In the present study, the bioaccessibility of BDE-28, 47, 99 and 153 in indoor dust was firstly investigated by using the in vitro digestion method. Bioaccessibility in intestinal phase (BDE-28: 24.5-30.1%; BDE-47: 6.99-13.0; BDE-99: 1.61-14.2%; and BDE-153 5.97-24.4%.) was higher than that in gastric phase (BDE-28: 38...
August 26, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27571313/optimizing-binding-energies-of-key-intermediates-for-co2-hydrogenation-to-methanol-over-oxide-supported-copper
#11
Shyam Kattel, Binhang Yan, Yixiong Yang, Jingguang G Chen, Ping Liu
Rational optimization of catalytic performance has been one of the major challenges in catalysis. Here we report a bottom-up study on the ability of TiO2 and ZrO2 to optimize the CO2 conversion to methanol on Cu, using combined density functional theory (DFT) calculations, kinetic Monte Carlo (KMC) simulations, in situ diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) measurements, and steady-state flow reactor tests. The theoretical results from DFT and KMC agree with in situ DRIFTS measurements, showing that both TiO2 and ZrO2 help to promote methanol synthesis on Cu via carboxyl intermediates and the reverse water-gas-shift (RWGS) pathway; the formate intermediates, on the other hand, likely act as a spectator eventually...
September 28, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27562838/the-effect-of-kangaroo-ward-care-in-comparison-with-intermediate-intensive-care-on-the-growth-velocity-in-preterm-infant-with-birth-weight-1100%C3%A2-g-randomized-control-trial
#12
Deepak Sharma, Srinivas Murki, Oleti Tejo Pratap
UNLABELLED: Kangaroo mother care (KMC) reduces neonatal mortality, neonatal sepsis and improves growth outcome in preterm infants. In this study, we compared the efficacy of "baby care in kangaroo ward (KWC)" with "baby care in intermediate intensive care (IIC)" in stable preterm infants (birth weight <1100 g) for improving the growth velocity till term corrected age. One hundred and forty-one infants were randomized to KWC (n = 71) or IIC (n = 70) once the infant reached a weight of 1150 g...
October 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27561228/theoretical-study-of-the-charge-transfer-state-separation-within-marcus-theory-the-c60-anthracene-case-study
#13
Riccardo Volpi, Racine Nassau, Morten Steen Nørby, Mathieu Linares
We study, within Marcus theory, the possibility of the charge-transfer (CT) state splitting at organic interfaces and a subsequent transport of the free charge carriers to the electrodes. As a case study we analyze model anthracene-C60 interfaces. Kinetic Monte Carlo (KMC) simulations on the cold CT state were performed at a range of applied electric fields, and with the fields applied at a range of angles to the interface to simulate the action of the electric field in a bulk heterojunction (BHJ) interface...
September 21, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27552521/kangaroo-mother-care-to-reduce-morbidity-and-mortality-in-low-birthweight-infants
#14
REVIEW
Agustin Conde-Agudelo, José L Díaz-Rossello
BACKGROUND: Kangaroo mother care (KMC), originally defined as skin-to-skin contact between a mother and her newborn, frequent and exclusive or nearly exclusive breastfeeding, and early discharge from hospital, has been proposed as an alternative to conventional neonatal care for low birthweight (LBW) infants. OBJECTIVES: To determine whether evidence is available to support the use of KMC in LBW infants as an alternative to conventional neonatal care before or after the initial period of stabilization with conventional care, and to assess beneficial and adverse effects...
August 23, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27545716/preventing-newborn-deaths-due-to-prematurity
#15
REVIEW
Kishwar Azad, Jiji Mathews
Preterm births (PTBs), defined as births before 37 weeks of gestation account for the majority of deaths in the newborn period. Prediction and prevention of PTB is challenging. A history of preterm labour or second trimester losses and accurate measurement of cervical length help to identify women who would benefit from progesterone and cerclage. Fibronectin estimation in the cervicovaginal secretions of a symptomatic woman with an undilated cervix can predict PTB within 10 days of testing. Antibiotics should be given to women with preterm prelabour rupture of membranes but tocolysis has a limited role in the management of preterm labour...
October 2016: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27538547/catalase-activity-in-healthy-and-inflamed-pulp-tissues-of-permanent-teeth-in-young-people
#16
Kmc Topcu, D Ö Kırıcı, M S Evcil
AIM: To evaluate catalase (CAT, EC 1.11.1.6) activity in healthy and inflamed dental pulp of young patient's teeth and to investigate if an active defense system oxidizing agents is present as a response to bacterial invasion. MATERIALS AND METHODS: Twenty young patients between 15 and 25 ages, who were diagnosed to be healthy, were the source of the pulp tissue. The situation of the dental pulps was evaluated using clinical and radiographic assessments. The patients were divided two groups from healthy, and inflamed pulp tissues were obtained; each participant provided one pulp tissue specimens...
September 2016: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/27504328/fertility-desires-and-intentions-among-people-living-with-hiv-aids-plwha-in-southern-india
#17
Hyma Jose, Deepak Madi, Nithyananda Chowta, John Ramapuram, Unnikrishnan Bhaskaran, Basavaprabhu Achappa, Vishnu Chandran
INTRODUCTION: The desire of people living with HIV/AIDS (PLWHA) to have children can have significant public health implications. Combination Antiretroviral Therapy (cART) has increased the life expectancy of PLWHA as a result of which they may consider child bearing. There are hardly any studies from India addressing the fertility desires among PLWHA. AIM: This study was done to assess the fertility desires of PLWHA in Southern India. MATERIALS AND METHODS: It was a cross-sectional study conducted among 230 HIV-positive men and women who presented to Kasturba Medical College (KMC), Mangalore, India...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27504270/cadaveric-study-on-morphology-of-dorsal-interossei-of-hand-and-its-anatomical-variation
#18
Vanishri S Nayak, Abhilasha Priya, Nandini Bhat, Sunil S Nayak, Antony Sylvan D'Souza, Hemalatha Bangera, Suhani Sumalatha
INTRODUCTION: The dorsal interossei are the abductors of the fingers and the knowledge of its variation help the surgeon in treatment of fractures, claw hand and compartment syndromes. AIM: To note the origin, insertion, pattern of muscle fibres and tendon length of all the dorsal interossei of hand. MATERIALS AND METHODS: Routinely dissected 30 formalin fixed hand in the Department of Anatomy, KMC, Manipal, were observed for origin, insertion and tendon length and muscle pattern of dorsal interossei...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27485211/low-prevalence-of-dihydro-folate-reductase-dhfr-and-dihydropteroate-synthase-dhps-quadruple-and-quintuple-mutant-alleles-associated-with-sp-resistance-in-plasmodium-vivax-isolates-of-west-bengal-india
#19
Sabyasachi Das, Abhijit Banik, Amiya Kumar Hati, Somenath Roy
BACKGROUND: Emergence of chloroquine resistant Plasmodium vivax is a serious obstacle towards malaria control in India. This study elucidates the temporal pattern of antifolate [sulfadoxine-pyrimethamine (SP)] resistance in P. vivax infection by means of genetic polymorphisms, especially analysing the single nucleotide polymorphisms of dihydrofolate reductase (pvdhfr) and dihydropteroate synthase (pvdhps) gene among the field isolates of urban Kolkata Municipal Corporation and rural Purulia region of West Bengal, India...
2016: Malaria Journal
https://www.readbyqxmd.com/read/27456294/utilizing-energy-transfer-in-binary-and-ternary-bulk-heterojunction-organic-solar-cells
#20
Krishna Feron, James M Cave, Mahir N Thameel, Connor O'Sullivan, Renee Kroon, Mats R Andersson, Xiaojing Zhou, Christopher J Fell, Warwick J Belcher, Alison B Walker, Paul C Dastoor
Energy transfer has been identified as an important process in ternary organic solar cells. Here, we develop kinetic Monte Carlo (KMC) models to assess the impact of energy transfer in ternary and binary bulk heterojunction systems. We used fluorescence and absorption spectroscopy to determine the energy disorder and Förster radii for poly(3-hexylthiophene-2,5-diyl), [6,6]-phenyl-C61-butyric acid methyl ester, 4-bis[4-(N,N-diisobutylamino)-2,6-dihydroxyphenyl]squaraine (DIBSq), and poly(2,5-thiophene-alt-4,9-bis(2-hexyldecyl)-4,9-dihydrodithieno[3,2-c:3',2'-h][1,5]naphthyridine-5,10-dione)...
August 17, 2016: ACS Applied Materials & Interfaces
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