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https://www.readbyqxmd.com/read/28062451/reckoner-read-error-corrector-based-on-kmc
#1
Maciej Długosz, Sebastian Deorowicz
: Presence of sequencing errors in data produced by next-generation sequencers affects quality of downstream analyzes. Accuracy of them can be improved by performing error correction of sequencing reads. We introduce a new correction algorithm capable of processing eukaryotic close to 500 Mbp-genome-size, high error-rated data using less than 4 GB of RAM in about 35 min on 16-core computer. AVAILABILITY AND IMPLEMENTATION: Program is freely available at http://sun...
January 5, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28047210/th-ab-bra-07-penelope-based-gpu-accelerated-dose-calculation-system-applied-to-mri-guided-radiation-therapy
#2
Y Wang, T Mazur, O Green, Y Hu, H Li, V Rodriguez, H Wooten, D Yang, T Zhao, S Mutic, H Li
PURPOSE: The clinical commissioning of IMRT subject to a magnetic field is challenging. The purpose of this work is to develop a GPU-accelerated Monte Carlo dose calculation platform based on PENELOPE and then use the platform to validate a vendor-provided MRIdian head model toward quality assurance of clinical IMRT treatment plans subject to a 0.35 T magnetic field. METHODS: We first translated PENELOPE from FORTRAN to C++ and validated that the translation produced equivalent results...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28017865/a-multi-scale-method-for-modelling-degradation-of-bioresorbable-polyesters
#3
Taohong Zhang, Shaonan Zhou, Xiaohao Gao, Zhiyong Yang, Leran Sun, Dezheng Zhang
: A multi-scale model using the Cellular Automata (CA) and kinetic Monte Carlo (KMC) methods is presented to simulate the degradation process of bioresorbable polyesters such as polylactide (PLA), polyglycolide (PGA) and their copolymers. The model considers the underlying chemical and physical events such as polymer chain scission, oligomer production, crystallisation induced by polymer chain scissions, oligomer diffusion and microstructure evolution due to erosion of the small chains...
December 22, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/28009335/influence-of-maternal-factors-on%C3%A2-the%C3%A2-successful-outcome-of-kangaroo-mother-care-in-low-birth-weight-infants-a%C3%A2-randomized-controlled-trial
#4
S N Lumbanraja
BACKGROUND: Kangaroo mother care (KMC) is associated with positive neonatal outcomes. Studies demonstrated significant influence of maternal factors on the success of applying KMC. AIM: To determine maternal factors that influence on anthropometric parameters in low birth weight babies that received kangaroo mother care. METHODS: This is a randomized controlled study that involved low birth weight newborns. We randomly assigned newborns into two groups; a group who received KMC and a group who received conventional care...
2016: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/27989952/randomized-controlled-trial-on-kangaroo-mother-care-in-bogot%C3%A3-cost-utility-analysis
#5
Juan Gabriel Ruiz, Nathalie Charpak, Mario Castillo, Astrid Bernal, John Ríos, Tammy Trujillo, María Adelaida Córdoba
INTRODUCTION: Although Kangaroo-Mother Care (KMC) has been shown to be safe and effective in randomized controlled trials (RCT), there are no published complete economic evaluations including the three components of the full intervention. METHODS: Cost-utility analysis on the results of a RCT conducted in Bogotá, Colombia between 1993 and 1996. Hospital and ambulatory costs were estimated by microcosting in a sample of preterm infants from a University Hospital in Bogotá in 2011, and at a KMC clinic in the same period...
October 27, 2016: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/27987366/when-alternative-female-kangaroo-care-is-provided-by-other-immediate-postpartum-mothers-it-reduces-post-procedural-pain-in-preterm-babies-more-than-swaddling
#6
Jitendranath Murmu, Kannan Venkatnarayan, Rajeev Kumar Thapar, Shubash Chandra Shaw, Shamsher Singh Dalal
AIM: Research on alternative female Kangaroo care (KC) has been hampered by high maternal refusal rates. We assessed the efficacy of Kangaroo mother care (KMC), alternative KC provided by other postpartum mothers and swaddling for post procedural pain relief in preterm babies. METHODS: The study was carried out in a tertiary armed forces hospital, where mothers did not have support from other female relatives and other postpartum mothers agreed to act as alternative female KC providers...
December 17, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27976654/rolling-out-of-kangaroo-mother-care-in-secondary-level-facilities-in-bihar-some-experiences
#7
Sutapa B Neogi, Monika Chauhan, Jyoti Sharma, Preeti Negandhi, Ghanshyam Sethy
BACKGROUND: Preterm birth is one of the leading causes of under-five child deaths worldwide and in India. Kangaroo mother care (KMC) is a powerful and easy-to-use method to promote health and well-being and reduce morbidity and mortality in preterm/low birth weight (LBW) babies. OBJECTIVE: As the part of the roll-out of India Newborn Action Plan interventions, we implemented KMC in select facilities with an objective to assess the responsiveness of public health system to roll out KMC...
October 2016: Indian Journal of Public Health
https://www.readbyqxmd.com/read/27973113/cost-assessment-of-implementation-of-immune-tolerance-induction-in-kmc-hospital
#8
B Babu, J P Kumar
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27965377/twenty-year-follow-up-of-kangaroo-mother-care-versus-traditional-care
#9
Nathalie Charpak, Rejean Tessier, Juan G Ruiz, Jose Tiberio Hernandez, Felipe Uriza, Julieta Villegas, Line Nadeau, Catherine Mercier, Francoise Maheu, Jorge Marin, Darwin Cortes, Juan Miguel Gallego, Dario Maldonado
BACKGROUND AND OBJECTIVES: Kangaroo mother care (KMC) is a multifaceted intervention for preterm and low birth weight infants and their parents. Short- and mid-term benefits of KMC on survival, neurodevelopment, breastfeeding, and the quality of mother-infant bonding were documented in a randomized controlled trial (RCT) conducted in Colombia from 1993 to 1996. The aim of the present study was to evaluate the persistence of these results in young adulthood. METHODS: From 2012 to 2014, a total of 494 (69%) of the 716 participants of the original RCT known to be alive were identified; 441 (62% of the participants in the original RCT) were re-enrolled, and results for the 264 participants weighing ≤1800 g at birth were analyzed...
January 2017: Pediatrics
https://www.readbyqxmd.com/read/27903890/pharos-collating-protein-information-to-shed-light-on-the-druggable-genome
#10
Dac-Trung Nguyen, Stephen Mathias, Cristian Bologa, Soren Brunak, Nicolas Fernandez, Anna Gaulton, Anne Hersey, Jayme Holmes, Lars Juhl Jensen, Anneli Karlsson, Guixia Liu, Avi Ma'ayan, Geetha Mandava, Subramani Mani, Saurabh Mehta, John Overington, Juhee Patel, Andrew D Rouillard, Stephan Schürer, Timothy Sheils, Anton Simeonov, Larry A Sklar, Noel Southall, Oleg Ursu, Dusica Vidovic, Anna Waller, Jeremy Yang, Ajit Jadhav, Tudor I Oprea, Rajarshi Guha
The 'druggable genome' encompasses several protein families, but only a subset of targets within them have attracted significant research attention and thus have information about them publicly available. The Illuminating the Druggable Genome (IDG) program was initiated in 2014, has the goal of developing experimental techniques and a Knowledge Management Center (KMC) that would collect and organize information about protein targets from four families, representing the most common druggable targets with an emphasis on understudied proteins...
January 4, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/27885658/early-skin-to-skin-contact-for-mothers-and-their-healthy-newborn-infants
#11
REVIEW
Elizabeth R Moore, Nils Bergman, Gene C Anderson, Nancy Medley
BACKGROUND: Mother-infant separation post birth is common. In standard hospital care, newborn infants are held wrapped or dressed in their mother's arms, placed in open cribs or under radiant warmers. Skin-to-skin contact (SSC) begins ideally at birth and should last continually until the end of the first breastfeeding. SSC involves placing the dried, naked baby prone on the mother's bare chest, often covered with a warm blanket. According to mammalian neuroscience, the intimate contact inherent in this place (habitat) evokes neuro-behaviors ensuring fulfillment of basic biological needs...
25, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27822298/towards-emic-rational-design-setting-the-molecular-simulation-toolbox-for-enantiopure-molecularly-imprinted-catalysts
#12
REVIEW
Tessa Jalink, Tom Farrand, Carmelo Herdes
A critical appraisal of the current strategies for the synthesis of enantiopure drugs is presented, along with a systematic background for the computational design of stereoselective porous polymers. These materials aim to achieve the enantiomeric excess of any chiral drug, avoiding the racemic separation. Particular emphasis is given to link statistical mechanics methods to the description of each one of the experimental stages within the catalyst's synthesis, setting a framework for the fundamental study of the emerging field of molecularly imprinted catalysts...
2016: Chemistry Central Journal
https://www.readbyqxmd.com/read/27800071/neonatal-transport-practices-in-ibadan-nigeria
#13
Muhydeen Abiodun Abdulraheem, Olukemi Oluwatoyin Tongo, Adebola Emmanuel Orimadegun, Olukayode Felix Akinbami
INTRODUCTION: Neonatal transport involves moving sick neonates in optimal conditions to ensure good outcomes. It is well organized in most developed countries but receives little attention in developing countries where the highest burden of neonatal mortality exists and a large number of newborns require referrals daily for better medical care. This study sought to evaluate the modes of transport, pre- and intra-transport care of neonates referred to the University College Hospital (UCH), Ibadan, Nigeria...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27765653/the-kangaroo-mother-care-method-from-scientific-evidence-generated-in-colombia-to-worldwide-practice
#14
Nathalie Charpak, Juan Gabriel Ruiz
Kangaroo Mother Care (KMC) is a human-based care intervention devised to complement neonatal care for low birth weight and premature infants. Kangaroo position (skin-to-skin contact on the mother's chest) offers thermal regulation, physiological stability, appropriate stimulation and enhances bonding and breastfeeding. Kangaroo nutrition is based on breastfeeding and kangaroo discharge policy relies on family empowerment and early discharge in kangaroo position with close ambulatory follow-up. We describe how the evidence has been developed, and how it has been put into practice by means of direct preterm infants care and dissemination of the method, including training of KMC excellence centers in many countries not only in Latin America but worldwide...
October 17, 2016: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/27743146/live-weight-conformation-carcass-traits-and-economic-values-of-ram-lambs-of-red-maasai-and-dorper-sheep-and-their-crosses
#15
E Zonabend König, J M K Ojango, J Audho, T Mirkena, E Strandberg, A M Okeyo, J Philipsson
Meat production is the most important trait in the breeding objectives of sheep production in East Africa. The aim of this study was to investigate breed differences in live weight, conformation, carcass traits and economic values for meat production among Red Maasai and Dorper sheep and their crosses. In total, 88 ram lambs, which were reared at the ILRI experimental station, Kapiti plains Estate in Central Kenya, were used for the study. The lambs were slaughtered at Kenya Meat Commission (KMC) at about 1 year of age...
January 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/27627386/microscopic-modeling-of-confined-crystal-growth-and-dissolution
#16
Jørgen Høgberget, Anja Røyne, Dag K Dysthe, Espen Jettestuen
We extend the (1+1)-dimensional fluid solid-on-solid (SOS) model to include a confining flat surface opposite to the SOS surface subject to a constant load. This load is balanced by a repulsive surface-surface interaction given by an ansatz which agrees with known analytical solutions in the limit of two separated flat surfaces. Mechanical equilibrium is imposed at all times by repositioning the confining surface. By the use of kinetic Monte Carlo (KMC) we calculate how the equilibrium concentration (deposition rate) depends on the applied load, and find it to reproduce analytical thermodynamics independent of the parameters of the interaction ansatz...
August 2016: Physical Review. E
https://www.readbyqxmd.com/read/27580070/surface-chemical-tuning-of-phonon-and-electron-transport-in-free-standing-silicon-nanowire-arrays
#17
Ying Pan, Ye Tao, Guangzhao Qin, Yuriy Fedoryshyn, Shyamprasad N Raja, Ming Hu, Christian L Degen, Dimos Poulikakos
We report electronic and phononic transport measurements of monocrystalline batch-fabricated silicon nanowire (SiNW) arrays functionalized with different surface chemistries. We find that hydrogen-terminated SiNWs prepared by vapor HF etching of native-oxide-covered devices show increased electrical conductivity but decreased thermal conductivity. We used the kinetic Monte Carlo method to solve the Boltzmann transport equation and also numerically examine the effect of phonon boundary scattering. Surface transfer doping of the SiNWs by cobaltocene or decamethylcobaltocene drastically improves the electrical conductivity by 2 to 4 orders of magnitude without affecting the thermal conductivity...
October 12, 2016: Nano Letters
https://www.readbyqxmd.com/read/27579255/an-assessment-of-maternal-newborn-and-child-health-implementation-studies-in-nigeria-implications-for-evidence-informed-policymaking-and-practice
#18
REVIEW
Chigozie Jesse Uneke, Issiaka Sombie, Namoudou Keita, Virgil Lokossou, Ermel Johnson, Pierre Ongolo-Zogo
BACKGROUND: The introduction of implementation science into maternal, newborn and child health (MNCH) research has facilitated better methods to improve uptake of research findings into practices. With increase in implementation research related to MNCH world-wide, stronger scientific evidence are now available and have improved MNCH policies in many countries including Nigeria. The purpose of this study was to review MNCH implementation studies undertaken in Nigeria in order to understand the extent the evidence generated informed better policy...
2016: Health Promotion Perspectives
https://www.readbyqxmd.com/read/27573363/in-vitro-digestion-and-absorption-of-bde-28-47-99-and-153-in-indoor-dust-and-its-implication-in-risk-assessment
#19
Yuan Kang, Weijian Pan, Siyun Liang, Lixuan Zeng, Qiuyun Zhang, Jiwen Luo, Xinmei Guo
The bioaccessibility of polybrominated diphenyl ethers (PBDEs) in indoor dust was estimated by a series of in vitro digestion methods. However, the absorption of PBDEs by intestinal cells after in vitro digestion was seldom studied. In the present study, the bioaccessibility of BDE-28, 47, 99 and 153 in indoor dust was firstly investigated by using the in vitro digestion method. Bioaccessibility in intestinal phase (BDE-28: 24.5-30.1%; BDE-47: 6.99-13.0; BDE-99: 1.61-14.2%; and BDE-153 5.97-24.4%.) was higher than that in gastric phase (BDE-28: 38...
August 26, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27571313/optimizing-binding-energies-of-key-intermediates-for-co2-hydrogenation-to-methanol-over-oxide-supported-copper
#20
Shyam Kattel, Binhang Yan, Yixiong Yang, Jingguang G Chen, Ping Liu
Rational optimization of catalytic performance has been one of the major challenges in catalysis. Here we report a bottom-up study on the ability of TiO2 and ZrO2 to optimize the CO2 conversion to methanol on Cu, using combined density functional theory (DFT) calculations, kinetic Monte Carlo (KMC) simulations, in situ diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) measurements, and steady-state flow reactor tests. The theoretical results from DFT and KMC agree with in situ DRIFTS measurements, showing that both TiO2 and ZrO2 help to promote methanol synthesis on Cu via carboxyl intermediates and the reverse water-gas-shift (RWGS) pathway; the formate intermediates, on the other hand, likely act as a spectator eventually...
September 28, 2016: Journal of the American Chemical Society
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