Shun Sasaki, Toru Murakami, Miharu Yasumuro, Ayaka Makita, Yutaro Oi, Yuta Hiragori, Shun Watanabe, Rin Kudo, Noriya Hayashi, Iwai Ohbayashi, Munetaka Sugiyama, Yui Yamashita, Satoshi Naito, Hitoshi Onouchi
Perturbations in ribosome biogenesis cause a type of cellular stress called nucleolar or ribosomal stress, which triggers adaptive responses in both animal and plant cells. The Arabidopsis ANAC082 transcription factor has been identified as a key mediator of the plant nucleolar stress response. The 5'-untranslated region (5'-UTR) of ANAC082 mRNA contains an upstream ORF (uORF) encoding an evolutionarily conserved amino acid sequence. Here, we report that this uORF mediates the upregulation of ANAC082 expression in response to nucleolar stress...
March 25, 2023: Plant Biotechnology (Tokyo, Japan)