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https://www.readbyqxmd.com/read/28443472/mir-26a-downregulates-retinoblastoma-in-colorectal-cancer
#1
Eduardo López-Urrutia, Jossimar Coronel-Hernández, Verónica García-Castillo, Carlos Contreras-Romero, Antonio Martínez-Gutierrez, Diana Estrada-Galicia, Luis Ignacio Terrazas, César López-Camarillo, Hector Maldonado-Martínez, Nadia Jacobo-Herrera, Carlos Pérez-Plasencia
MicroRNAs are non-coding short RNAs that target the 3' untranslated region of messenger RNAs (mRNAs) and lead to their degradation or to translational repression. Several microRNAs have been designated as oncomirs, owing to their regulating tumor suppressor genes. Interestingly, a few of them have been found to target multiple genes whose simultaneous suppression contributes to the development of a tumoral phenotype. Here, we have showed that miR-26a is overexpressed in colorectal cancer data obtained from TCGA Research Network and in human colon cancer pathological specimens; moreover, an orthotopic in vivo model of colon cancer showed overexpression of miR-26a, while Rb1 expression inversely correlated to miR-26a in TCGA Research Network data, pathological samples, and the in vivo model...
April 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28437392/should-we-administer-oxygen-during-an-acute-coronary-syndrome
#2
José Tomás Bennett-Laso, Tomás Kramer-Urrutia, Gabriel Rada
Oxygen therapy is used for the treatment of acute coronary syndrome without further discussion. However, the support of this practice in clinical research is scarce, ignoring the true effects of its implementation. To answer this question, we searched in Epistemonikos database, which is maintained by screening multiple information sources. We identified five systematic reviews including 12 studies overall, five of which were randomized trials. We extracted data, conducted a meta-analysis and generated a summary of findings table using the GRADE approach...
March 29, 2017: Medwave
https://www.readbyqxmd.com/read/28434739/the-effect-of-conjugated-linoleic-acid-acetate-and-their-interaction-on-adipose-tissue-lipid-metabolism-in-nonlactating-cows
#3
N Urrutia, Y Ying, K J Harvatine
During biohydrogenation-induced milk fat depression, adipose tissue lipogenesis may be increased through nutrients spared from milk fat synthesis. However, the direct effect of trans-10, cis-12 conjugated linoleic acid (CLA) and the indirect effect of spared nutrients on adipose tissue lipogenesis during milk fat depression is not clear. The objective of this study was to determine the direct effect of CLA, spared acetate, and their interaction on adipose tissue lipogenesis using nonlactating dairy cows as an experimental model, which allows separation of the effect of CLA and nutrient sparing...
April 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28423410/analysis-of-dislocation-configurations-in-a-0-0-1-fcc-single-crystal-by-electron-channeling-contrast-imaging-in-the-sem
#4
Ivan Gutierrez-Urrutia
We have investigated the dislocation configurations in a [0 0 1] single crystal of a face-centered alloy (316L stainless steel) by the electron channeling contrast imaging (ECCI) technique in the scanning electron microscope under controlled diffraction conditions. Specific dislocations such as piled-up dislocations and Lomer-Cottrell dislocations were characterized by the analysis of dislocation contrast and dislocation line trace analysis. The ECCI technique also allows the sound estimation of the local resolved stress acting on gliding dislocations by the analysis of the radius of curvature following a transmission electron microscopy-based geometrical approach...
April 1, 2017: Microscopy
https://www.readbyqxmd.com/read/28406071/validation-and-reliability-of-the-spanish-version-of-the-function-in-sitting-test-s-fist-to-assess-sitting-balance-in-subacute-post-stroke-adult-patients
#5
Rosa Cabanas-Valdés, Caritat Bagur-Calafat, Fernanda Maria Caballero-Gómez, Carmen Cervera-Cuenca, Raúl Moya-Valdés, Pere Ramón Rodríguez-Rubio, Gerard Urrútia
BACKGROUND: Function in Sitting Test (FIST) is a clinical functional assessment of sitting balance validated in adults with stroke. For a major use of this, the test is recommended to be translated in Spanish-speaking countries. OBJECTIVES: Translate to Spanish the FIST and determine its intra-rater and inter-rater reliabilities and concurrent validity as a measure of sitting balance in adult individuals with stroke. METHODS: The original version was translated into Spanish and was agreed by a team of experts...
April 13, 2017: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/28394955/-perceptions-about-the-elisa-test-of-people-diagnosed-at-the-aids-stage
#6
Paola Carrasco A, Alejandra X Araya G, Paula Vega, María Teresa Urrutia S, Miriam Rubio A, Claudio Trujillo G, María Jesús Lira S
BACKGROUND: The delay in the diagnosis of AIDS results in higher treatment costs. AIM: To reveal the experiences of people who were diagnosed in the AIDS stage about the access to the ELISA test. MATERIAL AND METHODS: In depth interviews were carried out to 15 participants from public hospitals who were in the AIDS stage at the moment of the diagnosis. The main questions asked were about the motivations to take the test, the barriers found and the help received from the health care personnel...
November 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28393989/-factors-affecting-compliance-with-pap-smear-screening
#7
María Teresa Urrutia, Macarena Gajardo
BACKGROUND: Pap smear coverage in Chile has gradually decreased in the last years, from 67% to 59%, making it necessary to determine the causes of this decline. AIM: To analyze the relationship between the characteristics of the cervical cancer screening target population in the public health care system and the percentage of PAP coverage. MATERIAL AND METHODS: This study was carried out in women aged between 25 and 64 years, belonging to a public health care system and registered in any of the eight primary healthcare centers of a Metropolitan Santiago low income community...
December 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28361100/a-novel-de-novo-frameshift-deletion-in-ehmt1-in-a-patient-with-kleefstra-syndrome-results-in-decreased-h3k9-dimethylation
#8
Patrick R Blackburn, Monique Williams, Margot A Cousin, Nicole J Boczek, Geoffrey J Beek, Gwen A Lomberk, Raul A Urrutia, Dusica Babovic-Vuksanovic, Eric W Klee
BACKGROUND: Kleefstra Syndrome (KS) (MIM# 610253) is an autosomal dominant disorder caused by haploinsufficiency of euchromatic histone methyltransferase-1 (EHMT1, GLP). EHMT1 (MIM# 607001) encodes a histone methyltransferase that heterodimerizes with EHMT2 (also known as G9a, MIM# 604599), which together are responsible for mono- and dimethylation of H3 lysine 9 (H3K9me1 and -me2), resulting in transcriptional repression of target genes. METHODS: This report describes an 18-year-old woman with intellectual disability, severely limited speech, hypotonia, microcephaly, and facial dysmorphisms, who was found to have a novel de novo single-base frameshift deletion in EHMT1...
March 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28351168/long-term-follow-up-of-a-randomized-controlled-trial-on-additional-core-stability-exercises-training-for-improving-dynamic-sitting-balance-and-trunk-control-in-stroke-patients
#9
Rosa Cabanas-Valdés, Caritat Bagur-Calafat, Montserrat Girabent-Farrés, Fernanda Mª Caballero-Gómez, Helena du Port de Pontcharra-Serra, Ana German-Romero, Gerard Urrútia
OBJECTIVE: Analyse the effect of core stability exercises in addition to conventional physiotherapy training three months after the intervention ended. DESIGN: A randomized controlled trial. SETTING: Outpatient services. SUBJECTS: Seventy-nine stroke survivors. INTERVENTIONS: In the intervention period, both groups underwent conventional physiotherapy performed five days/week for five weeks, and in addition the experimental group performed core stability exercises for 15 minutes/day...
March 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28344485/biochemical-and-molecular-modulation-of-ccl4-induced-peripheral-and-central-damage-by-tilia-americana-var-mexicanaextracts
#10
Elvia Coballase-Urrutia, Noemí Cárdenas-Rodríguez, María Carolina González-García, Eithan Núñez-Ramírez, Esaú Floriano-Sánchez, María Eva González-Trujano, Berenice Fernández-Rojas, José Pedraza-Chaverrí, Hortencia Montesinos-Correa, Liliana Rivera-Espinosa, Aristides Iii Sampieri, Liliana Carmona-Aparicio
Around the world, species from the genus Tilia are commonly used because of their peripheral and central medicinal effects; they are prepared as teas and used as tranquilizing, anticonvulsant, and analgesic agents. In this study, we provide evidence of the protective effects of organic and aqueous extracts (100 mg/kg, i.p.) obtained from the leaves of Tilia americana var. mexicana on CCl4-induced liver and brain damage in the rat. Protection was observed in the liver and brain (cerebellum, cortex and cerebral hemispheres) by measuring the activity of antioxidant enzymes and levels of malondialdehyde (MDA) using spectrophotometric methods...
March 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28340660/severe-crush-injury-to-the-forearm-and-hand-the-role-of-microsurgery
#11
REVIEW
Francisco Del Piñal, Esteban Urrutia, Maciej Klich
The main goals of treating severe crush injuries are debriding away devitalized tissue and filling any resultant dead space with vascularized tissue. In the authors' experience, the most ideal methods for soft tissue coverage in treating crush injuries are the iliac flap, the adipofascial lateral arm flap, and the gracilis flap. Accompanying bone defects respond very well to free corticoperiosteal flaps. Digital defects often require the use of complete or subtotal toe transfer to avoid amputation and restore function to the hand...
April 2017: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/28338878/risk-of-diabetes-after-hysterectomy-with-or-without-oophorectomy-in-postmenopausal-women
#12
Juhua Luo, JoAnn E Manson, Rachel Peragallo Urrutia, Michael Hendryx, Erin S LeBlanc, Karen L Margolis
The aim of this study was to determine the associations between hysterectomy, bilateral salpingo-oophorectomy (BSO), and incidence of diabetes in postmenopausal women participating in the Women's Health Initiative (WHI), a series of trials conducted in the United States, during the period 1993-1998. A total of 67,130 postmenopausal women aged 50-79 years were followed for a mean of 13.4 years. Among them, 7,430 cases of diabetes were diagnosed. Multivariable Cox proportional hazards models were used to assess the association between hysterectomy/oophorectomy status and diabetes incidence...
March 6, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28331053/acetate-dose-dependently-stimulates-milk-fat-synthesis-in-lactating-dairy-cows
#13
Natalie L Urrutia, Kevin J Harvatine
Background: Acetate is a short-chain fatty acid (FA) that is especially important to cows because it is the major substrate for de novo FA synthesis. However, the effect of acetate supply on mammary lipid synthesis is not clear.Objective: The objective of this experiment was to determine the effect of increasing acetate supply on milk fat synthesis in lactating dairy cows.Methods: Six multiparous lactating Holstein cows were randomly assigned to treatments in a replicated design to investigate the effect of acetate supply on milk fat synthesis...
March 22, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28330575/clinical-management-of-the-homozygous-%C3%AE-thalassemia-with-unusual-mandibular-manifestation-of-hematopoiesis
#14
J A Ruiz-Roca, R E Oñate-Sánchez, I Urrutia-Rodríguez, A Martínez-Izquierdo, D Mengual-Pujante, F J Rodríguez-Lozano
Alpha (α)-thalassemias are the most common genetic disorder of hemoglobin (Hb) synthesis, affecting up to 5% of the world's population. These congenital hemolytic anemias induce extramedullary hematopoiesis, including the liver, spleen, sinuses, and the diploic spaces of the skull. Oral health problems in patients with thalassemias are mostly related to a varied degree of facial deformities, malocclusions, and/or dental arch dimensions. We present a case with a 49-year-old man, diagnosed with homozygous α thalassemia that came to the Faculty of Dentistry at the University of Murcia for a dental treatment...
February 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28294290/genetic-obesity-risk-and-attenuation-effect-of-physical-fitness-in-mexican-mestizo-population-a-case-control-study
#15
Paula Costa-Urrutia, Carolina Abud, Valentina Franco-Trecu, Valentina Colistro, Martha Eunice Rodríguez-Arellano, Joel Vázquez-Pérez, Julio Granados, Marilia Seelaender
We analyzed commonly reported European and Asian obesity-related gene variants in a Mexican-Mestizo population through each single nucleotide polymorphism (SNP) and a genetic risk score (GRS) based on 23 selected SNPs. Study subjects were physically active Mexican-Mestizo adults (n  =  608) with body mass index (BMI) values from 18 to 55 kg/m(2) . For each SNP and for the GRS, logistic models were performed to test for simple SNP associations with BMI, fat mass percentage (FMP), waist circumference (WC), and the interaction with VO2max and muscular endurance (ME)...
March 15, 2017: Annals of Human Genetics
https://www.readbyqxmd.com/read/28292609/organic-micropollutants-omps-oxidation-by-ozone-effect-of-activated-carbon-on-toxicity-abatement
#16
Oscar Rozas, Carolina Baeza, Katherine Núñez, Alfred Rossner, Roberto Urrutia, Héctor D Mansilla
Oxidation and removal of organic micropollutants (OMPs) on ultrapure (UPW) and natural water (NW) by ozone (O3) and ozone/powdered activated carbon (O3/PAC) have been studied. The OMPs atrazine (ATZ, herbicide), carbamazepine (CBZ, anticonvulsant), diclofenac (DCL, anti-inflammatory) and triclosan (TCS, antimicrobial) are incorporated continuously and uncontrolled on water treatment systems (e.g., drinking water treatment plants, wastewater treatment plants). Batch experiments on ultrapure and natural water showed that ATZ treated with O3 and O3/PAC has the slowest transformation rate (>90% at 30min reaction) while CBZ, DCL and TCS were oxidized very fast (>90% at ~5min)...
March 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28289718/elucidation-of-mras-mediated-noonan-syndrome-with-cardiac-hypertrophy
#17
Erin M Higgins, J Martijn Bos, Heather Mason-Suares, David J Tester, Jaeger P Ackerman, Calum A MacRae, Katia Sol-Church, Karen W Gripp, Raul Urrutia, Michael J Ackerman
Noonan syndrome (NS; MIM 163950) is an autosomal dominant disorder and a member of a family of developmental disorders termed "RASopathies," which are caused mainly by gain-of-function mutations in genes encoding RAS/MAPK signaling pathway proteins. Whole exome sequencing (WES) and trio-based genomic triangulation of a 15-year-old female with a clinical diagnosis of NS and concomitant cardiac hypertrophy and her unaffected parents identified a de novo variant in MRAS-encoded RAS-related protein 3 as the cause of her disease...
March 9, 2017: JCI Insight
https://www.readbyqxmd.com/read/28283607/individual-and-system-contributions-to-race-and-sex-disparities-in-thrombolysis-use-for-stroke-patients-in-the-united-states
#18
Roland Faigle, Victor C Urrutia, Lisa A Cooper, Rebecca F Gottesman
BACKGROUND AND PURPOSE: Intravenous thrombolysis (IVT) is underutilized in ethnic minorities and women. To disentangle individual and system-based factors determining disparities in IVT use, we investigated race/sex differences in IVT utilization among hospitals serving varying proportions of minority patients. METHODS: Ischemic stroke admissions were identified from the Nationwide Inpatient Sample between 2007 and 2011. Hospitals were categorized based on the percentage of minority patients admitted with stroke (<25% minority patients [white hospitals], 25% to 50% minority patients [mixed hospitals], or >50% minority patients [minority hospitals])...
April 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28276648/reference-values-for-tsh-may-be-inadequate-to-define-hypothyroidism-in-persons-with-morbid-obesity-di-bet-es-study
#19
Sergio Valdés, Cristina Maldonado-Araque, Ana Lago-Sampedro, Juan Antonio Lillo-Muñoz, Eduardo Garcia-Fuentes, Vidal Perez-Valero, Carolina Gutiérrez-Repiso, Eva Garcia-Escobar, Albert Goday, Inés Urrutia, Laura Peláez, Alfonso Calle-Pascual, Elena Bordiú, Luis Castaño, Conxa Castell, Elias Delgado, Edelmiro Menéndez, Josep Franch-Nadal, Sonia Gaztambide, Joan Girbés, Emilio Ortega, Joan Vendrell, Matilde R Chacón, F Javier Chaves, Federico Soriguer, Gemma Rojo-Martínez
OBJECTIVE: To analyze the reference range of thyroid-stimulating hormone (TSH) in different BMI categories and its impact on the classification of hypothyroidism. METHODS: The study included 3,928 individuals free of thyroid disease (without previous thyroid disease, no interfering medications, TSH <10 µUI/mL and thyroid peroxidase antibodies [TPO Abs] <50 IU/mL) who participated in a national, cross-sectional, population-based study and were representative of the adult population of Spain...
March 9, 2017: Obesity
https://www.readbyqxmd.com/read/28275007/gene-expression-profiling-of-patient-derived-pancreatic-cancer-xenografts-predicts-sensitivity-to-the-bet-bromodomain-inhibitor-jq1-implications-for-individualized-medicine-efforts
#20
Benjamin Bian, Martin Bigonnet, Odile Gayet, Celine Loncle, Aurélie Maignan, Marine Gilabert, Vincent Moutardier, Stephane Garcia, Olivier Turrini, Jean-Robert Delpero, Marc Giovannini, Philippe Grandval, Mohamed Gasmi, Mehdi Ouaissi, Veronique Secq, Flora Poizat, Rémy Nicolle, Yuna Blum, Laetitia Marisa, Marion Rubis, Jean-Luc Raoul, James E Bradner, Jun Qi, Gwen Lomberk, Raul Urrutia, Andres Saul, Nelson Dusetti, Juan Iovanna
c-MYC controls more than 15% of genes responsible for proliferation, differentiation, and cellular metabolism in pancreatic as well as other cancers making this transcription factor a prime target for treating patients. The transcriptome of 55 patient-derived xenografts show that 30% of them share an exacerbated expression profile of MYC transcriptional targets (MYC-high). This cohort is characterized by a high level of Ki67 staining, a lower differentiation state, and a shorter survival time compared to the MYC-low subgroup...
April 2017: EMBO Molecular Medicine
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