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https://www.readbyqxmd.com/read/29787575/safety-of-intravenous-alteplase-within-4-5-hours-for-patients-awakening-with-stroke-symptoms
#1
Victor C Urrutia, Roland Faigle, Steven R Zeiler, Elisabeth B Marsh, Mona Bahouth, Mario Cerdan Trevino, Jennifer Dearborn, Richard Leigh, Susan Rice, Karen Lane, Mustapha Saheed, Peter Hill, Rafael H Llinas
BACKGROUND: Up to 25% of acute stroke patients first note symptoms upon awakening. We hypothesized that patients awaking with stroke symptoms may be safely treated with intravenous alteplase (IV tPA) using non-contrast head CT (NCHCT), if they meet all other standard criteria. METHODS: The SAfety of Intravenous thromboLytics in stroke ON awakening (SAIL ON) was a prospective, open-label, single treatment arm, pilot safety trial of standard dose IV tPA in patients who presented with stroke symptoms within 0-4...
2018: PloS One
https://www.readbyqxmd.com/read/29786102/the-ucp2-866g-a-ala55val-and-ucp3-55c-t-polymorphisms-are-associated-with-premature-coronary-artery-disease-and-cardiovascular-risk-factors-in-mexican-population
#2
Ricardo Gamboa, Claudia Huesca-Gómez, Vanessa López-Pérez, Rosalinda Posadas-Sánchez, Guillermo Cardoso-Saldaña, Aida Medina-Urrutia, Juan Gabriel Juárez-Rojas, María Elena Soto, Carlos Posadas-Romero, Gilberto Vargas-Alarcón
We examined the role of UCP gene polymorphisms as susceptibility markers for premature coronary artery disease (pCAD). The UCP2 Ala55Val (C/T rs660339), UCP2 -866G/A (rs659366), and UCP3 -55C/T (rs1800849) polymorphisms were genotyped in 948 patients with pCAD, and 763 controls. The distribution of the UCP2 A55V (C/T rs660339) and UCP3 -55 (rs1800849) was similar in patients and controls. However, under a recessive model, the UCP2 -866 (rs659366) A allele was associated with increased risk of developing pCAD (OR = 1...
May 21, 2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29773832/distinct-epigenetic-landscapes-underlie-the-pathobiology-of-pancreatic-cancer-subtypes
#3
Gwen Lomberk, Yuna Blum, Rémy Nicolle, Asha Nair, Krutika Satish Gaonkar, Laetitia Marisa, Angela Mathison, Zhifu Sun, Huihuang Yan, Nabila Elarouci, Lucile Armenoult, Mira Ayadi, Tamas Ordog, Jeong-Heon Lee, Gavin Oliver, Eric Klee, Vincent Moutardier, Odile Gayet, Benjamin Bian, Pauline Duconseil, Marine Gilabert, Martin Bigonnet, Stephane Garcia, Olivier Turrini, Jean-Robert Delpero, Marc Giovannini, Philippe Grandval, Mohamed Gasmi, Veronique Secq, Aurélien De Reyniès, Nelson Dusetti, Juan Iovanna, Raul Urrutia
Recent studies have offered ample insight into genome-wide expression patterns to define pancreatic ductal adenocarcinoma (PDAC) subtypes, although there remains a lack of knowledge regarding the underlying epigenomics of PDAC. Here we perform multi-parametric integrative analyses of chromatin immunoprecipitation-sequencing (ChIP-seq) on multiple histone modifications, RNA-sequencing (RNA-seq), and DNA methylation to define epigenomic landscapes for PDAC subtypes, which can predict their relative aggressiveness and survival...
May 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29756711/smoke-free-adolescents-effectiveness-of-an-educational-intervention-controlled-before-and-after-study
#4
Pablo E Gulayin, Vilma Irazola, Adolfo Rubinstein, Rodrigo Bruno, André Rossi Díaz, Miguel Gulayin, María I Urrutia, Ariel Bardach
No abstract text is available yet for this article.
June 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29753272/street-dust-from-a-heavily-populated-and-industrialized-city-evaluation-of-spatial-distribution-origins-pollution-ecological-risks-and-human-health-repercussions
#5
R Urrutia-Goyes, N Hernandez, O Carrillo-Gamboa, K D P Nigam, N Ornelas-Soto
Emissions from vehicles include particles from tire and brake wearing that can settle down and join industrial discharges into street dust. Metals present in street dust may create ecological and health threats and their analysis is of great environmental relevance. The city of Monterrey, Mexico is an industrial pillar of the country and shows an increasing fleet during the last years, which has yielded higher traffic and emissions. This study analyzes 44 street dust samples taken across the city for total element concentrations by using X-ray fluorescence...
May 9, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29747696/oxidative-modifications-of-foetal-ldl-c-and-hdl-c-lipoproteins-in-preeclampsia
#6
G León-Reyes, S Espino Y Sosa, R Medina-Navarro, A M Guzmán-Grenfell, A X Medina-Urrutia, S Fuentes-García, G J J Hicks, Y D Torres-Ramos
BACKGROUND: Oxidative modifications have been observed in lipids and proteins in lipoproteins isolated from women with preeclampsia. Thus, newborns could also be susceptible to this damage directly through their mothers. In this study, we evaluated the oxidative profile of LDL-c and HDL-c lipoproteins isolated from the umbilical cord from newborns born to women with preeclampsia. METHODS: Thirty newborns born to women with preeclampsia and thirty newborns born to women with healthy pregnancies were included...
May 10, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29744810/correction-to-intranasal-cotinine-plus-krill-oil-facilitates-fear-extinction-decreases-depressive-like-behavior-and-increases-hippocampal-calcineurin-a-levels-in-mice
#7
Nathalie Alvarez-Ricartes, Patricia Oliveros-Matus, Cristhian Mendoza, Nelson Perez-Urrutia, Florencia Echeverria, Alexandre Iarkov, George E Barreto, Valentina Echeverria
The original version of this article unfortunately contained mistake in its Funding inforation.
April 26, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29742719/cauda-equina-syndrome-following-an-uneventful-spinal-anesthesia-in-a-patient-undergoing-drainage-of-the-bartholin-abscess-a-case-report
#8
Waldo Merino-Urrutia, Milca Villagrán-Schmidt, Priscilla Ulloa-Vásquez, Rubén Carrasco-Moyano, Alberto Uribe, Nicoleta Stoicea, Sergio D Bergese
RATIONALE: Neuraxial anesthesia is a commonly used type of regional anesthesia. Cauda equina syndrome is an unusual and severe complication of neuraxial anesthesia, and is caused by damage to the sacral roots of the neural canal. We present a case of cauda equina syndrome following spinal anesthesia in a patient who underwent Bartholin abscess drainage. PATIENT CONCERNS: A 23-year old female scheduled to undergo surgical drainage of Bartholin abscess. Spinal anesthesia was performed with bupivacaine and fentanyl...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29735791/vitamin-d-deficiency-is-not-associated-with-fatty-liver-in-a-mexican-population
#9
Fabiola López-Bautista, Carlos Posadas-Romero, Luz Y Ruiz-Vargas, Guillermo Cardoso-Saldaña, Juan G Juárez-Rojas, Aida Medina-Urrutia, Nonanzit Pérez-Hernández, José M Rodríguez-Pérez, Gilberto Vargas-Alarcón, Rosalinda Posadas-Sánchez
INTRODUCTION AND AIM: Association of vitamin D deficiency (VDD) with fatty liver (FL) disease is controversial. The purpose of this study was to analyze the association of VDD with FL. MATERIAL AND METHODS: Cross-sectional study. Data on cardiovascular risk factors, medications, alcohol intake, smoking, diet, and physical activity were obtained. Biochemical, anthropometric, and blood pressure variables were measured. The 25-hydroxyvitamin D (25(OH)D) was quantified through chemoluminescence...
April 9, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29725081/publisher-correction-natural-variation-in-the-parameters-of-innate-immune-cells-is-preferentially-driven-by-genetic-factors
#10
Etienne Patin, Milena Hasan, Jacob Bergstedt, Vincent Rouilly, Valentina Libri, Alejandra Urrutia, Cécile Alanio, Petar Scepanovic, Christian Hammer, Friederike Jönsson, Benoît Beitz, Hélène Quach, Yoong Wearn Lim, Julie Hunkapiller, Magge Zepeda, Cherie Green, Barbara Piasecka, Claire Leloup, Lars Rogge, François Huetz, Isabelle Peguillet, Olivier Lantz, Magnus Fontes, James P Di Santo, Stéphanie Thomas, Jacques Fellay, Darragh Duffy, Lluís Quintana-Murci, Matthew L Albert
In the version of this article initially published, the name of one author was incorrect (James P. Santo). The correct name is James P. Di Santo. The error has been corrected in the HTML and PDF versions of the article.
May 3, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29720562/airway-responsiveness-to-methacholine-and-incidence-of-copd-an-international-prospective-cohort-study
#11
Alessandro Marcon, Francesca Locatelli, Dirk Keidel, Anna B Beckmeyer-Borowko, Isa Cerveri, Shyamali C Dharmage, Elaine Fuertes, Judith Garcia-Aymerich, Joachim Heinrich, Medea Imboden, Christer Janson, Ane Johannessen, Bénédicte Leynaert, Silvia Pascual Erquicia, Giancarlo Pesce, Emmanuel Schaffner, Cecilie Svanes, Isabel Urrutia, Deborah Jarvis, Nicole M Probst-Hensch, Simone Accordini
BACKGROUND: It has been debated, but not yet established, whether increased airway responsiveness can predict COPD. Recognising this link may help in identifying subjects at risk. OBJECTIVE: We studied prospectively whether airway responsiveness is associated with the risk of developing COPD. METHODS: We pooled data from two multicentre cohort studies that collected data from three time points using similar methods (European Community Respiratory Health Survey and Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults)...
May 2, 2018: Thorax
https://www.readbyqxmd.com/read/29709548/the-meta-score-for-differentiating-metastatic-from-osteoporotic-vertebral-fractures-an-independent-agreement-assessment
#12
Pablo Besa, Julio Urrutia, Mauricio Campos, Sebastián Mobarec, Juan Pablo Cruz, Pablo Cikutovic, Gonzalo Diaz
BACKGROUND CONTEXT: Differentiating osteoporotic vertebral fractures (OVF) from metastatic vertebral fractures (MVF) is an important clinical challenge. A novel magnetic resonance imaging- (MRI) based score (the META score) was described, aiming to differentiate OVF and MVF. This score showed an almost perfect agreement by the group developing it, but an independent agreement evaluation is pending. PURPOSE: To perform an independent inter- and intra-observer agreement evaluation of the META score...
April 27, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29702168/use-of-chitosan-heterofunctionality-for-enzyme-immobilization-%C3%AE-galactosidase-immobilization-for-galacto-oligosaccharide-synthesis
#13
Paulina Urrutia, Claudia Bernal, Lorena Wilson, Andrés Illanes
Chitosan partially functionalized with aldehyde groups was used for enzyme immobilization, favoring first the enzyme adsorption through its amino groups and then the covalent bonding of the adsorbed catalyst through the aldehyde groups of the support. Using this strategy, immobilized A. oryzae β-galactosidase had a better performance than when only the aldehyde groups were used. The performance was further improved by modifying the support aldehyde group density to 200 μmoles⋅g-1 . The biocatalyst under optimized immobilization conditions had 2951 IU⋅g-1 and half-life of 46...
April 24, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29700318/iron-deficiency-is-associated-with-hypothyroxinemia-and-hypotriiodothyroninemia-in-the-spanish-general-adult-population-di-bet-es-study
#14
Cristina Maldonado-Araque, Sergio Valdés, Ana Lago-Sampedro, Juan Antonio Lillo-Muñoz, Eduardo Garcia-Fuentes, Vidal Perez-Valero, Carolina Gutierrez-Repiso, Albert Goday, Ines Urrutia, Laura Peláez, Alfonso Calle-Pascual, Luis Castaño, Contxa Castell, Elias Delgado, Edelmiro Menendez, Josep Franch-Nadal, Sonia Gaztambide, Joan Girbés, Emilio Ortega, Joan Vendrell, Matilde R Chacón, Felipe J Chaves, Federico Soriguer, Gemma Rojo-Martínez
Previous studies have suggested that iron deficiency (ID) may impair thyroid hormone metabolism, however replication in wide samples of the general adult population has not been performed. We studied 3846 individuals free of thyroid disease, participants in a national, cross sectional, population based study representative of the Spanish adult population. Thyroid stimulating hormone (TSH), free thyroxin (FT4) and free triiodothyronine (FT3) were analyzed by electrochemiluminescence (E170, Roche Diagnostics)...
April 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29696957/-turicella-otitidis-contributions-to-its-role-in-the-etiology-of-ear-infections
#15
M De Frutos, L López-Urrutia, R Aragón, A M Vegas, M Vázquez, J M Eiros Bouza
OBJECTIVE: Turicella otitidis is a gram-positive bacillus coryneforme described, after 16S RNA sequencing, in 1994 by Funke et al as a microorganism involved in otitis media, and it is in health conditions a habitual colonizer of the external auditory canal. Since its description, more than twenty years ago, few cases of otitis related to or directly attributed to this microorganism have been published. METHODS: Description of a case of mastoiditis that required surgery and other cases of otic pathology in which T...
April 26, 2018: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/29690488/a-new-species-of-nurse-frog-aromobatidae-allobates-from-the-juami-river-basin-northwestern-brazilian-amazonia
#16
Pedro Ivo SimÕes, Giussepe Gagliardi-Urrutia, Fernando J M Rojas-Runjaic, Santiago Castroviejo-Fisher
We describe a new species of nurse-frog (Aromobatidae, Allobates) from northwestern Brazilian Amazon. Allobates juami sp. nov. is distinguished from similar congeneric species by the combination of the following characters: body-size range (snout-to-vent length 17.5-18.5 mm), lack of dark pigments on ventral surfaces of male specimens, dorsal color pattern (predominantly solid dark brown, but conspicuously light brown over snout and urostyle regions), presence of conspicuous pale dorsolateral and ventrolateral stripes, and presence of a diffuse pale paracloacal mark...
February 26, 2018: Zootaxa
https://www.readbyqxmd.com/read/29677445/new-amphiphilic-composite-for-preparing-efficient-coated-potassium-fertilizers-for-top-dressing-fertilization-of-annual-crops
#17
Oscar Urrutia, Javier Erro, Andre Vinicius Zabini, Kent Hoshiba, Anne Francoise Blandin, Roberto Baigorri, Manuel Martin-Pastor, Yves Alis, Jean-Claude Yvin, José María García-Mina
This study describes the efficiency of a new coating material for preparing granulated potassium-fertilizers with a potassium release to the soil solution sensitive to rainfall intensity. The composite is prepared by reaction of an alkyd-resin with cement in the absence of water. The complementary use of diverse analytical techniques showed that the presence of the cement fraction induced alkyd resin reticulation and gradual cement-resin hardening. Scanning electron microscopy revealed the formation of micro and nanopores within cement-clusters, whose water permeability is affected by the resin reticulation and amphiphilic character...
April 20, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29623154/choosing-wisely-together-physical-and-occupational-therapy-consultation-for-acute-neurology-inpatients
#18
John C Probasco, Annette Lavezza, Andre Cassell, Tenise Shakes, Angie Feurer, Holly Russell, Hilary Sporney, Margie Burnett, Chepkorir Maritim, Victor Urrutia, H Adrian Puttgen, Michael Friedman, Erik H Hoyer
Background: Although many hospitalized neuroscience patients have physical and occupational therapy (rehabilitation) needs, patients with none or minimal physical impairments frequently receive rehabilitation consultation, diverting from patients with greatest need. Methods: A multidisciplinary team on the general and cerebrovascular neurology acute inpatient services mapped the rehabilitation consultation process, resulting in multiple implemented interventions including physician education on appropriate acute rehabilitation consultations, modification of multidisciplinary rounds, and discussion of patient rehabilitation needs throughout hospitalization...
April 2018: Neurohospitalist
https://www.readbyqxmd.com/read/29605637/genome-sequence-of-two-members-of-the-chloroaromatic-degrading-mt-community-pseudomonas-reinekei-mt1-and-achromobacter-xylosoxidans-mt3
#19
Izabook Gutierrez-Urrutia, Matthieu J Miossec, Sandro L Valenzuela, Claudio Meneses, Vitor A P Martins Dos Santos, Eduardo Castro-Nallar, Ignacio Poblete-Castro
We describe the genome sequence of Pseudomonas reinekei MT1 and Achromobacter xylosoxidans MT3, the most abundant members of a bacterial community capable of degrading chloroaromatic compounds. The MT1 genome contains open reading frames encoding enzymes responsible for the catabolism of chlorosalicylate, methylsalicylate, chlorophenols, phenol, benzoate, p-coumarate, phenylalanine, and phenylacetate. On the other hand, the MT3 strain genome possesses no ORFs to metabolize chlorosalicylates; instead the bacterium is capable of metabolizing nitro-phenolic and phenolic compounds, which can be used as the only carbon and energy source by MT3...
March 29, 2018: Journal of Biotechnology
https://www.readbyqxmd.com/read/29600090/global-alliance-against-chronic-respiratory-diseases-gard-brazil-success-case-overcoming-barriers
#20
EDITORIAL
Alvaro A Cruz, Paulo A Camargos, Marilyn Urrutia-Pereira, Rafael Stelmach
No abstract text is available yet for this article.
January 2018: Journal of Thoracic Disease
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