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https://www.readbyqxmd.com/read/29340039/integrative-molecular-network-analysis-identifies-emergent-enzalutamide-resistance-mechanisms-in-prostate-cancer
#1
Carly J King, Josha Woodward, Jacob Schwartzman, Daniel J Coleman, Robert Lisac, Nicholas J Wang, Kathryn Van Hook, Lina Gao, Joshua Urrutia, Mark A Dane, Laura M Heiser, Joshi J Alumkal
Recent work demonstrates that castration-resistant prostate cancer (CRPC) tumors harbor countless genomic aberrations that control many hallmarks of cancer. While some specific mutations in CRPC may be actionable, many others are not. We hypothesized that genomic aberrations in cancer may operate in concert to promote drug resistance and tumor progression, and that organization of these genomic aberrations into therapeutically targetable pathways may improve our ability to treat CRPC. To identify the molecular underpinnings of enzalutamide-resistant CRPC, we performed transcriptional and copy number profiling studies using paired enzalutamide-sensitive and resistant LNCaP prostate cancer cell lines...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29338962/knowledge-on-asthma-food-allergies-and-anaphylaxis-assessment-of-elementary-school-teachers-parents-caregivers-of-asthmatic-children-and-university-students-in-uruguaiana-in-the-state-of-rio-grande-do-sul-brazil
#2
M Urrutia-Pereira, L P Mocellin, R B de Oliveira, L Simon, L Lessa, D Solé
INTRODUCTION: Allergic diseases have become an increasingly common reality in the last years, extending beyond the family context. OBJECTIVE: Assessing the level of knowledge on asthma, food allergies and anaphylaxis of asthmatic children's parents/caregivers (PC), elementary school teachers (EST) and university students (US) in Uruguaiana, RS, Brazil. METHOD: 577 individuals (PC - N=111; EST - N=177; US - N=299) took part in the study, answering the Newcastle Asthma Knowledge Questionnaire (validated for Portuguese) and another questionnaire on Food Allergy (FA) and anaphylaxis...
January 12, 2018: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29333845/-script-concordance-test-first-nationwide-experience-in-pediatrics
#3
Magali Hamui, Juan P Ferreira, Milagros Torrents, Fernando Torres, Mariano Ibarra, Maria F Ossorio, Luis Urrutia, Fernando Ferrero
The Script Concordance Test is a suitable test for assessing clinical reasoning in postgraduate medical education. We present the first nationwide, realtime, web-based experience of a Script Concordance Test administered to 3rd year pediatric residents. The test was administered to 268 residents (postgraduate year 3), from 56 different programs, requiring 46.1 ± 27.1 minutes to complete it, and scoring 65.3 ± 7.47 points. A later survey showed limited satisfaction from participants. This experience showed that this kind of test is feasible in this setting...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29283434/elevation-of-the-head-during-intensive-care-management-in-people-with-severe-traumatic-brain-injury
#4
REVIEW
Jose D Alarcon, Andres M Rubiano, David O Okonkwo, Jairo Alarcón, Maria José Martinez-Zapata, Gerard Urrútia, Xavier Bonfill Cosp
BACKGROUND: Traumatic brain injury (TBI) is a major public health problem and a fundamental cause of morbidity and mortality worldwide. The burden of TBI disproportionately affects low- and middle-income countries. Intracranial hypertension is the most frequent cause of death and disability in brain-injured people. Special interventions in the intensive care unit are required to minimise factors contributing to secondary brain injury after trauma. Therapeutic positioning of the head (different degrees of head-of-bed elevation (HBE)) has been proposed as a low cost and simple way of preventing secondary brain injury in these people...
December 28, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29282317/distinctive-roles-of-age-sex-and-genetics-in-shaping-transcriptional-variation-of-human-immune-responses-to-microbial-challenges
#5
Barbara Piasecka, Darragh Duffy, Alejandra Urrutia, Hélène Quach, Etienne Patin, Céline Posseme, Jacob Bergstedt, Bruno Charbit, Vincent Rouilly, Cameron R MacPherson, Milena Hasan, Benoit Albaud, David Gentien, Jacques Fellay, Matthew L Albert, Lluis Quintana-Murci
The contribution of host genetic and nongenetic factors to immunological differences in humans remains largely undefined. Here, we generated bacterial-, fungal-, and viral-induced immune transcriptional profiles in an age- and sex-balanced cohort of 1,000 healthy individuals and searched for the determinants of immune response variation. We found that age and sex affected the transcriptional response of most immune-related genes, with age effects being more stimulus-specific relative to sex effects, which were largely shared across conditions...
December 27, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29275077/human-mycobacterium-bovis-infection-in-castile-and-le%C3%A3-n-spain-2006-2015
#6
Teresa Nebreda-Mayoral, M Fé Brezmes-Valdivieso, Nieves Gutiérrez-Zufiaurre, Susana García-de Cruz, Cristina Labayru-Echeverría, Ramiro López-Medrano, Luis López-Urrutia-Lorente, Almudena Tinajas-Puertas, Octavio Rivero-Lezcano
INTRODUCTION: The annual incidence of tuberculosis (TB) from Mycobacterium bovis in humans has considerably declined in industrialised countries since the early twentieth century. The objective of this study was to determine the epidemiological, clinical and microbiological characteristics of patients with this illness in Castile and León (CyL). METHODS: Retrospective study of all M. bovis TB cases in CyL over a 10-year period, comparing the risk factors, the epidemiology and the clinical course between pulmonary (PTB) and extrapulmonary TB (EPTB)...
December 20, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29273355/what-is-the-most-important-for-elite-control-genetic-background-of-patient-genetic-background-of-partner-both-or-neither-description-of-complete-natural-history-within-a-couple-of-msm
#7
M Bendenoun, A Samri, V Avettand-Fènoël, S Cardinaud, B Descours, G Carcelain, M-C Mazeron, J-F Bergmann, A Urrutia, A Moris, C Rouzioux, F Simon, P Andre, M Pocard, X Dray, T Mourez, V Vieillard, B Autran, F Barin, P Sellier
BACKGROUND: We describe a homosexual man who strongly controlled HIV-1 for ten years despite lack of protective genetic background. METHODS: HIV-1 DNA was measured in blood and other tissues. Cell susceptibility was evaluated with various strains. HIV-1-specific (CD4 and CD8 activation markers and immune check points) and NK cells responses were assessed; KIRs haplotypes and HLA alleles were determined. FINDINGS: Two HIV-1 RNA copies/mL of plasma were detected in 2009, using an ultra-sensitive assay...
December 7, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29246872/immobilization-of-lipases-in-hydrophobic-chitosan-for-selective-hydrolysis-of-fish-oil-the-impact-of-support-functionalization-on-lipase-activity-selectivity-and-stability
#8
P Urrutia, R Arrieta, L Alvarez, C Cardenas, M Mesa, L Wilson
The objective of this paper was to carry out an integral study of the use of hydrophobic chitosan as a low-cost support for immobilizing lipases and their further application in the selective hydrolysis of fish oil. Chitosan functionalized with different alkyl chains (C4, C8, C12) were characterized by FTIR, TGA, SEM, and Rose Bengal adsorption. Lipase B from Candida antarctica (CalB) and lipase from Rhizomucor miehei (RML) were immobilized obtaining a higher expressed activity at a longer alkyl chain length of support...
December 13, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29239557/variability-of-nutrients-intake-lipid-profile-and-cardiovascular-mortality-among-geographical-areas-in-spain-the-drece-study
#9
Agustín Gómez de la Cámara, Eva De Andrés Esteban, Gerard Urrútia Cuchí, Enrique Calderón Sandubete, Miguel Ángel Rubio Herrera, Miguel Menéndez Orenga, David Lora Pablos
It has often been suggested that cardiovascular mortality and their geographical heterogeneity are associated with nutrients intake patterns and also lipid profile. The large Spanish study Dieta y Riesgo de Enfermedades Cardiovasculares en España (DRECE) investigated this theory from 1991 to 2010. Out of the 4,783 Spanish individuals making up the DRECE cohort, 220 subjects (148 men and 72 women) died (4.62%) during the course of the study. The mean age of patients who died from cardiovascular causes (32 in all) was 61...
November 7, 2017: Geospatial Health
https://www.readbyqxmd.com/read/29236843/weakness-acquired-in-the-intensive-care-unit-incidence-risk-factors-and-their-association-with-inspiratory-weakness-observational-cohort-study
#10
Ladislao Pablo Diaz Ballve, Nahuel Dargains, José García Urrutia Inchaustegui, Antonella Bratos, Maria de Los Milagros Percaz, Cesar Bueno Ardariz, Sabrina Cagide, Carolina Balestrieri, Claudio Gamarra, Dario Paz, Eliana Rotela, Sebastian Muller, Fernando Bustos, Ricard Aranda Castro, Esteban Settembrino
OBJECTIVE: This paper sought to determine the accumulated incidence and analyze the risk factors associated with the development of weakness acquired in the intensive care unit and its relationship to inspiratory weakness. METHODS: We conducted a prospective cohort study at a single center, multipurpose medical-surgical intensive care unit. We included adult patients who required mechanical ventilation ≥ 24 hours between July 2014 and January 2016. No interventions were performed...
December 7, 2017: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/29233831/the-efficacy-of-the-proprioceptive-neuromuscular-facilitation-pnf-approach-in-stroke-rehabilitation-to-improve-basic-activities-of-daily-living-and-quality-of-life-a-systematic-review-and-meta-analysis-protocol
#11
Francesc Xavier Guiu-Tula, Rosa Cabanas-Valdés, Mercè Sitjà-Rabert, Gerard Urrútia, Natàlia Gómara-Toldrà
INTRODUCTION: Proprioceptive neuromuscular facilitation (PNF) is a widely used rehabilitation concept, although its efficacy has not yet been demonstrated in stroke survivors. The aim of this systematic review is to identify, assess and synthesise the potential benefits of using PNF to improve the activities of daily living (ADL) and quality of life (QoL) of individuals with stroke. METHODS AND ANALYSIS: A systematic electronic search will be conducted in MEDLINE, Embase, CENTRAL and PEDro...
December 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29226140/prevalence-of-helicobacter-pylori-vaca-genotypes-and-caga-gene-in-dental-plaque-of-asymptomatic-mexican-children
#12
Alejandra Mendoza-Cantú, Víctor Hugo Urrutia-Baca, Cynthia Sofía Urbina-Ríos, Myriam Angélica De la Garza-Ramos, Martha Elena García-Martínez, Hilda H H Torre-Martínez
The variability in Helicobacter pylori vacA and cagA genes has been related to the progression of the gastrointestinal disease; also the presence of H. pylori in the oral cavity has been associated with periodontal disease in adults, but, in children without dyspeptic symptoms, little is known about this. We evaluated the prevalence of H. pylori and the presence of vacA/cagA genotypes in the oral cavity of Mexican children without dyspeptic symptoms. The gingival status was measured, and dental plaque samples (n = 100) were taken...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29217364/collaterals-predict-outcome-regardless-of-time-last-known-normal
#13
Richa Sharma, Rafael H Llinas, Victor Urrutia, Elisabeth B Marsh
BACKGROUND AND PURPOSE: Recent studies suggest that patients with large-vessel ischemic strokes (large-vessel occlusion [LVO]) with favorable imaging may benefit from mechanical thrombolysis even when treated outside the standard 6-hour window. However, many patients in these studies presented with unknown times of onset. We compare outcomes in thrombectomy patients treated at less than versus greater than 6 hours from last known well (LKN), and evaluate whether "unknown time of onset" alters prognosis...
December 4, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29192400/historical-anthropogenic-mercury-in-two-lakes-of-central-chile-comparison-between-an-urban-and-rural-lake
#14
Denisse Álvarez, Fernando Torrejón, María José Climent, Jordi Garcia-Orellana, Alberto Araneda, Roberto Urrutia
Mercury concentrations in the environment tend to decrease in recent years due to environmental restrictions. Lakes store mercury in their sediments, making them potential secondary contamination sources. In South America, the occurrence of mercury in lake systems has been associated mainly with volcanic emissions and only few records anthropogenic contamination in the pre-Hispanic period. The objective of this research was to study historical anthropogenic mercury concentration in two lakes in Central Chile (La Señoraza and Pillo), in order to establish background mercury levels and their variations from preindustrial to modern periods...
November 30, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29186684/pancreatic-adenocarcinoma-therapeutic-targets-revealed-by-tumor-stroma-cross-talk-analyses-in-patient-derived-xenografts
#15
Rémy Nicolle, Yuna Blum, Laetitia Marisa, Celine Loncle, Odile Gayet, Vincent Moutardier, Olivier Turrini, Marc Giovannini, Benjamin Bian, Martin Bigonnet, Marion Rubis, Nabila Elarouci, Lucile Armenoult, Mira Ayadi, Pauline Duconseil, Mohamed Gasmi, Mehdi Ouaissi, Aurélie Maignan, Gwen Lomberk, Jean-Marie Boher, Jacques Ewald, Erwan Bories, Jonathan Garnier, Anthony Goncalves, Flora Poizat, Jean-Luc Raoul, Veronique Secq, Stephane Garcia, Philippe Grandval, Marine Barraud-Blanc, Emmanuelle Norguet, Marine Gilabert, Jean-Robert Delpero, Julie Roques, Ezequiel Calvo, Fabienne Guillaumond, Sophie Vasseur, Raul Urrutia, Aurélien de Reyniès, Nelson Dusetti, Juan Iovanna
Preclinical models based on patient-derived xenografts have remarkable specificity in distinguishing transformed human tumor cells from non-transformed murine stromal cells computationally. We obtained 29 pancreatic ductal adenocarcinoma (PDAC) xenografts from either resectable or non-resectable patients (surgery and endoscopic ultrasound-guided fine-needle aspirate, respectively). Extensive multiomic profiling revealed two subtypes with distinct clinical outcomes. These subtypes uncovered specific alterations in DNA methylation and transcription as well as in signaling pathways involved in tumor-stromal cross-talk...
November 28, 2017: Cell Reports
https://www.readbyqxmd.com/read/29178871/efficacy-and-safety-of-tiotropium-and-olodaterol-in-copd-a-systematic-review-and-meta-analysis
#16
Marc Miravitlles, Gerard Urrutia, Alexander G Mathioudakis, Julio Ancochea
BACKGROUND: Long-acting bronchodilators are the cornerstone of pharmacologic treatment of COPD. The new combination of long-acting muscarinic antagonist (LAMA) tiotropium (TIO) and long acting beta-agonists (LABA) olodaterol (OLO) has been introduced as fist line therapy for COPD. This article analyses the evidence of efficacy and safety of the TIO/OLO combination. METHODS: A systematic review and metaanalysis of randomized controlled trials (RCT) with a period of treatment of at least 6 weeks, in patients with COPD confirmed by spirometry, comparing combined treatment with TIO/OLO (approved doses only), with any of the mono-components or any other active comparator administered as an inhalator...
November 25, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29148744/the-fundamental-noninnocent-role-of-water-for-the-hydrogenation-of-nitrous-oxide-by-pnp-pincer-ru-based-catalysts
#17
Jesús A Luque-Urrutia, Albert Poater
The hydrogenation of nitrous oxide by PNP pincer ruthenium complexes supposes a promising way to functionalize a hazardous gas and reduce the greenhouse effect, generating dinitrogen and water. Here, by DFT calculations we describe not only the whole mechanism for such a green transformation but we unravel the fundamental role of water, without which the reaction could not go forward. Water assists mandatorily in the H transfer to generate the hydroxyl group together with the release of dinitrogen.
November 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29113151/alternative-splicing-regulation-in-tumor-necrosis-factor-mediated-inflammation
#18
Eduardo López-Urrutia, Alma Campos-Parra, Luis Alonso Herrera, Carlos Pérez-Plasencia
It is generally accepted that alternative splicing has an effect on disease when it leads to conspicuous changes in relevant proteins, but that the combinatorial effect of several small modifications can have marked outcomes as well. Inflammation is a complex process involving numerous signaling pathways, among which the tumor necrosis factor (TNF) pathway is one of the most studied. Signaling pathways are commonly represented as intricate cascades of molecular interactions that eventually lead to the activation of one or several genes...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29103130/in-vitro-antimicrobial-activity-and-downregulation-of-virulence-gene-expression-on-helicobacter-pylori-by-reuterin
#19
Víctor Hugo Urrutia-Baca, Erandi Escamilla-García, Myriam Angélica de la Garza-Ramos, Patricia Tamez-Guerra, Ricardo Gomez-Flores, Cynthia Sofía Urbina-Ríos
Helicobacter pylori is an infectious agent commonly associated with gastrointestinal diseases. The use of probiotics to treat this infection has been documented, however, their potential antimicrobial metabolites have not yet been investigated. In the present study, the effect of reuterin produced by Lactobacillus reuteri on H. pylori growth and virulence gene expression was evaluated. It was observed that reuterin caused significant (P < 0.05) H. pylori growth inhibition at concentrations from 0.08 to 20...
November 4, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29102540/sudden-hearing-loss-with-vertigo-portends-greater-stroke-risk-than-sudden-hearing-loss-or-vertigo-alone
#20
Tzu-Pu Chang, Zheyu Wang, Ariel A Winnick, Hsun-Yang Chuang, Victor C Urrutia, John P Carey, David E Newman-Toker
BACKGROUND: Because it is unknown whether sudden hearing loss (SHL) in acute vertigo is a "benign" sign (reflecting ear disease) or a "dangerous" sign (reflecting stroke), we sought to compare long-term stroke risk among patients with (1) "SHL with vertigo," (2) "SHL alone," and (3) "vertigo alone" using a large national health-care database. METHODS: Patients with first-incident SHL (International Classification of Diseases, Ninth Edition, Clinical Modification [ICD-9-CM] 388...
November 1, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
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