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M de Frutos, L López-Urrutia, C Berbel, M Allue, S Herrera, J M Azcona, X Beristaín, E Aznar, M Albert, C Ruiz, J M Eiros
This report presents an outbreak of monophasic Salmonella enteric serovar Typhimurium fagotipe 4, 5, 12: i:-, in a motorcycle concentration in Valladolid. Information was collected to one hundred and twelve affected from seven Spanish Autonomous Communities. The epidemiological investigation associated the outbreak with the consumption of roast pork with sauce sandwiches sold at a street market in that event.
March 20, 2018: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
Sergio Contreras, Josef P Werne, A Araneda, R Urrutia, C A Conejero
Paleolimnological studies in western South America, where meteorological stations are scarce, are critical to obtain more realistic and reliable regional reconstructions of past climate and environmental changes, including vegetation and water budget variability. However, climate and environmental geochemical indicators must be tested before they can be applied with confidence. Here we present a survey of lacustrine surface sediment (core top, 0 to ~1cm) biogeochemical proxies (total organic carbon [TOC], total nitrogen [TN], carbon/nitrogen ratio [C/N ratio] and bulk organic δ13 C and total δ15 N) from a suite of 72 lakes spanning the transition from a Mediterranean climate with a patchwork of cultivated vegetation, pastureland, and conifers in central Chile to a rainy temperate climate dominated by broadleaf deciduous and evergreen forest further south...
February 27, 2018: Science of the Total Environment
Francisco Márquez, Isabel Iturrieta, Mario Calvo, Milton Urrutia, Patricio Godoy-Martínez
BACKGROUND: Candidemia disease in Chile is not very known, despite being a very common and serious disease. AIM: To analyze incidence and susceptibility profile of species from the genus Candida in Hospital Base Valdivia. MATERIAL AND METHODS: All candidemia cases presented between March 2009 and August 2011 in our institution were identified. Species distribution and susceptibility were studied through the disk diffusion method. RESULTS: Twenty-seven candidemia episodes were studied...
October 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
Nathalie Alvarez-Ricartes, Patricia Oliveros-Matus, Cristhian Mendoza, Nelson Perez-Urrutia, Florencia Echeverria, Alexandre Iarkov, George E Barreto, Valentina Echeverria
Failure in fear extinction is one of the more troublesome characteristics of posttraumatic stress disorder (PTSD). Cotinine facilitates fear memory extinction and reduces depressive-like behavior when administered 24 h after fear conditioning in mice. In this study, it was investigated the behavioral and molecular effects of cotinine, and other antidepressant preparations infused intranasally. Intranasal (IN) cotinine, IN krill oil, IN cotinine plus krill oil, and oral sertraline were evaluated on depressive-like behavior and fear retention and extinction after fear conditioning in C57BL/6 mice...
February 27, 2018: Molecular Neurobiology
Julio Urrutia, Pablo Besa, Daniel Lobos, Marcelo Andia, Cristobal Arrieta, Sergio Uribe
PURPOSE: Lumbar paraspinal muscle morphology has recently been evaluated in several studies with conflicting results. Several studies have performed single-slice evaluations of paraspinal muscle morphology, whereas other studies have done a multi-level assessment; this methodological difference might explain the observed different results. Our study evaluated if a single-slice axial measurement is representative of the entire lumbar musculature. METHODS: We included 80 adult patients who were consecutively evaluated with magnetic resonance imaging (MRI) for spinal symptoms...
February 23, 2018: Skeletal Radiology
Etienne Patin, Milena Hasan, Jacob Bergstedt, Vincent Rouilly, Valentina Libri, Alejandra Urrutia, Cécile Alanio, Petar Scepanovic, Christian Hammer, Friederike Jönsson, Benoît Beitz, Hélène Quach, Yoong Wearn Lim, Julie Hunkapiller, Magge Zepeda, Cherie Green, Barbara Piasecka, Claire Leloup, Lars Rogge, François Huetz, Isabelle Peguillet, Olivier Lantz, Magnus Fontes, James P Santo, Stéphanie Thomas, Jacques Fellay, Darragh Duffy, Lluís Quintana-Murci, Matthew L Albert
The quantification and characterization of circulating immune cells provide key indicators of human health and disease. To identify the relative effects of environmental and genetic factors on variation in the parameters of innate and adaptive immune cells in homeostatic conditions, we combined standardized flow cytometry of blood leukocytes and genome-wide DNA genotyping of 1,000 healthy, unrelated people of Western European ancestry. We found that smoking, together with age, sex and latent infection with cytomegalovirus, were the main non-genetic factors that affected variation in parameters of human immune cells...
February 23, 2018: Nature Immunology
Francisco Estrada-Rojo, Julio Morales-Gomez, Elvia Coballase-Urrutia, Marina Martinez-Vargas, Luz Navarro
OBJECTIVE: Data from our laboratory suggest that recovery from a traumatic brain injury depends on the time of day at which it occurred. In this study, we examined whether traumatic brain injury -induced damage is related to circadian variation in N-methyl-D-aspartate receptor expression in rat cortex. RESULTS: We confirmed that traumatic brain injury recovery depended on the time of day at which the damage occurred. We also found that motor cortex N-methyl-D-aspartate receptor subunit NR1 expression exhibited diurnal variation in both control and traumatic brain injury-subjected rats...
February 21, 2018: BMC Research Notes
Hamleth Valois-Cuesta, Carolina Martínez-Ruiz, Yorley Urrutia-Rivas
Mining is one of the main economic activities in many tropical regions and is the cause of devastation of large areas of natural tropical forests. The knowledge of the regenerative potential of mining disturbed areas provides valuable information for their ecological restoration. The aim of this study was to evaluate the effect of age of abandonment of mines and their distance from the adjacent forest, on the formation of soil seed bank in abandoned mines in the San Juan, Chocó, Colombia. To do this, we determined the abundance and species composition of the soil seed bank, and the dynamics of seed rain in mines of different cessation period of mining activity (6 and 15 years), and at different distances from the adjacent forest matrix (50 and 100 m)...
March 2017: Revista de Biología Tropical
Ali S Saber Tehrani, Jorge C Kattah, Kevin A Kerber, Daniel R Gold, David S Zee, Victor C Urrutia, David E Newman-Toker
No abstract text is available yet for this article.
March 2018: Stroke; a Journal of Cerebral Circulation
Changwei Dou, Zhikui Liu, Kangsheng Tu, Hongbin Zhang, Chen Chen, Usman Yaqoob, Yuanguo Wang, Jialing Wen, Jan van Deursen, Delphine Sicard, Daniel Tschumperlin, Hongzhi Zou, Wei-Chien Huang, Raul Urrutia, Vijay H Shah, Ningling Kang
BACKGROUND & AIMS: Hepatic stellate cells (HSCs) contribute to desmoplasia and stiffness of liver metastases by differentiating into matrix-producing myofibroblasts. We investigated whether stiffness due to the presence of tumors increases activation of HSCs into myofibroblasts and their tumor-promoting effects, as well as the role of E1A binding protein p300 (EP300 or p300), a histone acetyltransferase that regulates transcription, in these processes. METHODS: HSCs were isolated from liver tissues of patients, mice in which the p300 gene was flanked by 2 loxP sites (p300F/F mice), and p300+/+ mice (controls)...
February 15, 2018: Gastroenterology
Øistein Svanes, Randi J Bertelsen, Stein Hl Lygre, Anne E Carsin, Josep M Antó, Bertil Forsberg, José M García-García, José A Gullón, Joachim Heinrich, Mathias Holm, Manolis Kogevinas, Isabel Urrutia, Bénédicte Leynaert, Jesús M Moratalla, Nicole Le Moual, Theodore Lytras, Dan Norbäck, Dennis Nowak, Mario Olivieri, Isabelle Pin, Nicole Probst-Hensch, Vivi Schlünssen, Torben Sigsgaard, Trude D Skorge, Simona Villani, Debbie Jarvis, Jan P Zock, Cecilie Svanes
RATIONALE: Cleaning tasks may imply exposure to chemical agents with potential harmful effects to the respiratory system, and increased risk of asthma and respiratory symptoms among professional cleaners and in persons cleaning at home has been reported. The long-term consequences of cleaning agents on respiratory health are, however, not well described. OBJECTIVES: This paper aims to investigate long-term effects of occupational cleaning and cleaning at home on lung function decline and chronic airway obstruction...
February 16, 2018: American Journal of Respiratory and Critical Care Medicine
Niluksha Walalawela, Mariana Vignoni, María Noel Urrutia, Sarah J Belh, Edyta M Greer, Andrés H Thomas, Alexander Greer
Alkylation patterns and excited state properties of pterins were examined both experimentally and theoretically. 2D NMR spectroscopy was used to characterize the pterin derivatives, revealing undoubtedly that the decyl chains were coupled to either the O4 or N3 sites on the pterin. At a temperature of 70 °C the pterin alkylation regioselectively favored the O4 over the N3. The O4 was also favored when using solvents in which the reactants had increased solubility, namely N,N-dimethylformamide and N,N-dimethylacetamide, rather than solvents in which the reactants had very low solubility (tetrahydrofuran and dichloromethane)...
February 13, 2018: Photochemistry and Photobiology
Eugene Urrutia, Hao Chen, Zilu Zhou, Nancy R Zhang, Yuchao Jiang
Summary: Copy number variation is an important and abundant source of variation in the human genome, which has been associated with a number of diseases, especially cancer. Massively parallel next-generation sequencing allows copy number profiling with fine resolution. Such efforts, however, have met with mixed successes, with setbacks arising partly from the lack of reliable analytical methods to meet the diverse and unique challenges arising from the myriad experimental designs and study goals in genetic studies...
February 5, 2018: Bioinformatics
Mariano Colón-Caraballo, Annelyn Torres-Reverón, John Lee Soto-Vargas, Steven Young, Bruce Lessey, Adalberto Mendoza, Raúl Urrutia, Idhaliz Flores
Although the histone methyltransferase EZH2 and its product H3K27me3 are well studied in cancer, little is known about their role and potential as therapeutic targets in endometriosis. We have previously reported that endometriotic lesions are characterized by global enrichment of H3K27me3. Therefore, we aimed to 1) characterize the expression levels of EZH2 in endometriotic tissues, 2) assess H3K27me3 enrichment in candidate genes promoter regions, and 3) determine if pharmacological inhibition of EZH2 impacts migration, proliferation, and invasion of endometriotic cells...
February 2, 2018: Biology of Reproduction
Arturo Meissner-Haecker, Julio Urrutia
INTRODUCTION: Surgical treatment of lumbar degenerative spondylolisthesis usually involves an interbody fusion in addition to a posterolateral fusion. However, the value of this procedure has not been established. METHODS: To answer this question we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of findings table using the GRADE approach...
January 30, 2018: Medwave
Julio Urrutia, Pablo Besa, Daniel Lobos, Mauricio Campos, Cristobal Arrieta, Marcelo Andia, Sergio Uribe
PURPOSE: To determine the association of paraspinal muscles and psoas relative cross-sectional area (RCSA) and fat signal fraction (FSF) with sex, age, and intervertebral disc degeneration (IDD) in symptomatic patients. METHODS: We retrospectively evaluated 80 adult patients with spinal symptoms using T2-weighted magnetic resonance images. We determined RCSA and FSF of the paraspinal muscles (erector spinae and multifidus) and psoas from L1-L2 to L5-S1; we determined IDD using the Pfirrmann classification...
January 29, 2018: Skeletal Radiology
Roland Faigle, Joseph A Carrese, Lisa A Cooper, Victor C Urrutia, Rebecca F Gottesman
BACKGROUND: Percutaneous endoscopic gastrostomy (PEG) tubes are widely used for enteral feeding after stroke; however, PEG tubes placed in patients in whom death is imminent are considered non-beneficial. AIM: We sought to determine whether placement of non-beneficial PEG tubes differs by race and sex. DESIGN AND SETTING/PARTICIPANTS: In this retrospective cohort study, inpatient admissions for stroke patients who underwent palliative/withdrawal of care, were discharged to hospice, or died during the hospitalization, were identified from the Nationwide Inpatient Sample between 2007 and 2011...
2018: PloS One
Carly J King, Josha Woodward, Jacob Schwartzman, Daniel J Coleman, Robert Lisac, Nicholas J Wang, Kathryn Van Hook, Lina Gao, Joshua Urrutia, Mark A Dane, Laura M Heiser, Joshi J Alumkal
Recent work demonstrates that castration-resistant prostate cancer (CRPC) tumors harbor countless genomic aberrations that control many hallmarks of cancer. While some specific mutations in CRPC may be actionable, many others are not. We hypothesized that genomic aberrations in cancer may operate in concert to promote drug resistance and tumor progression, and that organization of these genomic aberrations into therapeutically targetable pathways may improve our ability to treat CRPC. To identify the molecular underpinnings of enzalutamide-resistant CRPC, we performed transcriptional and copy number profiling studies using paired enzalutamide-sensitive and resistant LNCaP prostate cancer cell lines...
December 19, 2017: Oncotarget
M Urrutia-Pereira, L P Mocellin, R B de Oliveira, L Simon, L Lessa, D Solé
INTRODUCTION: Allergic diseases have become an increasingly common reality in the last years, extending beyond the family context. OBJECTIVE: Assessing the level of knowledge on asthma, food allergies and anaphylaxis of asthmatic children's parents/caregivers (PC), elementary school teachers (EST) and university students (US) in Uruguaiana, RS, Brazil. METHOD: 577 individuals (PC - N=111; EST - N=177; US - N=299) took part in the study, answering the Newcastle Asthma Knowledge Questionnaire (validated for Portuguese) and another questionnaire on Food Allergy (FA) and anaphylaxis...
January 12, 2018: Allergologia et Immunopathologia
Magali Hamui, Juan P Ferreira, Milagros Torrents, Fernando Torres, Mariano Ibarra, Maria F Ossorio, Luis Urrutia, Fernando Ferrero
The Script Concordance Test is a suitable test for assessing clinical reasoning in postgraduate medical education. We present the first nationwide, realtime, web-based experience of a Script Concordance Test administered to 3rd year pediatric residents. The test was administered to 268 residents (postgraduate year 3), from 56 different programs, requiring 46.1 ± 27.1 minutes to complete it, and scoring 65.3 ± 7.47 points. A later survey showed limited satisfaction from participants. This experience showed that this kind of test is feasible in this setting...
February 1, 2018: Archivos Argentinos de Pediatría
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