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Yunfang Jia, Fang Li
Functional nucleic acids (FNAs) are promising sensing elements, extensive interests are excited to integrate FNAs with transducers for biochemical assays. However, efforts for FNAs modified light-addressable-potentiometric-sensor (FNA-LAPS) are rarely reported. LAPS is a versatile transducer with electrolyte-insulator-semiconductor (EIS) structure, can respond almost any surface electronic deviations. Herein, organized studies for FNA-LAPS including experiments, theoretical derivations and MEDICI (Synopsys®) simulations, are presented using Pb2+ -DNAzyme GR-5 and Ag+ -aptamer as proof-of-concepts, which are typical FNAs with distinctive sensing strategies...
March 21, 2018: Analytical Chemistry
Chia-Chun Wu, Jen-Der Lin, Jeng-Ting Chen, Chih-Min Chang, Hsiao-Fen Weng, Chuen Hsueh, Hui-Ping Chien, Jau-Song Yu
Thyroid ultrasound and ultrasound-guided fine-needle aspiration (USG/FNA) biopsy are currently used for diagnosing papillary thyroid carcinoma (PTC), but their detection limit could be improved by combining other biomarkers. To discover novel PTC biomarkers, we herein applied a GeLC-MS/MS strategy to analyze the proteome profiles of serum-abundant-protein-depleted FNA cystic fluid from benign and PTC patients, as well as two PTC cell line secretomes. From them, we identified 346, 488, and 2105 proteins, respectively...
February 23, 2018: Oncotarget
Yuki Tanisaka, Shomei Ryozawa, Masanori Kobayashi, Maiko Harada, Tsutomu Kobatake, Kumiko Omiya, Hirotoshi Iwano, Shin Arai, Kouichi Nonaka, Yumi Mashimo
Lymphadenopathy may be difficult to diagnose using imaging results alone. Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) may help to diagnose and determine the appropriate management of lymphadenopathy. EUS-FNA has been used as a safe and less invasive method for obtaining pathologic specimens from extraluminal lesions using endoscopic ultrasound. The present study evaluated the usefulness of EUS-FNA for lymphadenopathy. Between July 2013 and December 2016, 72 patients undergoing EUS-FNA for lymphadenopathy that could not be diagnosed solely using imaging were included...
April 2018: Oncology Letters
Kentaro Moriichi, Mikihiro Fujiya, Takuma Goto, Toshikatsu Okumura
No abstract text is available yet for this article.
March 13, 2018: Endoscopic Ultrasound
Suguru Mizuno, Yousuke Nakai, Hiroyuki Isayama, Tatsunori Suzuki, Kei Saito, Rie Uchino, Naminatsu Takahara, Hirofumi Kogure, Minoru Tada, Kazuhiko Koike
No abstract text is available yet for this article.
March 12, 2018: Endoscopic Ultrasound
Ji Young Bang, Udayakumar Navaneethan, Muhammad K Hasan, Robert Hawes, Shyam Varadarajulu
BACKGROUND & AIMS: Outcomes of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) evaluation vary with technique, needles, and methods of specimen evaluation. We performed a direct comparison of diagnostic yields of EUS-FNA samples collected using different gauge needles (22- vs 25-gauge), with or without suction. METHODS: We performed a randomized controlled study of 352 patients with suspected pancreatic masses, referred for EUS-FNA at a tertiary referral center...
March 10, 2018: Clinical Gastroenterology and Hepatology
Wan Yang, Shilong He, Ming Han, Bingbing Wang, Qigui Niu, Yujia Xu, Yi Chen, Haibo Wang
In this study, the nitrogen removal performance and microbial community structure were investigated during the start-up, instability, and recovery stages of an anaerobic ammonium oxidation (anammox) reactor loaded with compound carriers (shale ceramsite and suspended ball carrier). The results indicated that the anammox reactor successfully started up on 116th d when the nitrogen loading rate (NLR) reached 0.72 ± 0.05 kg N m-3  d-1 . The anammox reactor ran well with free ammonia (FA) at 13.65 ± 2...
March 10, 2018: Journal of Bioscience and Bioengineering
Vincent P Groot, Sameer S Thakker, Georgios Gemenetzis, Michaël Noë, Ammar A Javed, Richard A Burkhart, Behnoud B Noveiry, John L Cameron, Matthew J Weiss, Christopher J VandenBussche, Elliot K Fishman, Ralph H Hruban, Christopher L Wolfgang, Anne Marie Lennon, Jin He
BACKGROUND: Lymphoepithelial cysts (LECs) are rare pancreatic cystic lesions. Since LECs are benign, preoperative diagnosis is important to differentiate from a cystic neoplasm and avoid unnecessary surgery. The aim of this study was to identify clinical, radiographic and cytopathologic features associated with LECs. METHODS: A retrospective review was performed of patients diagnosed with LEC between 1995 and 2017 at our hospital. Clinicopathologic and radiographic imaging features were documented...
March 9, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Jeong-Min Lee, Jeonghoon Ha, Kwanhoon Jo, Yejee Lim, Min-Hee Kim, Chan-Kwan Jung, So-Lyung Jung, Moo-Il Kang, Bong-Yun Cha, Dong-Jun Lim
Background/Aims: Lymphocytic thyroiditis as cytology diagnosis from fine needle aspiration (FNA) is frequently detected in patients with thyroid nodules. However, the clinical outcome for upcoming hypothyroid events has been rarely clarified in euthyroid patients. Methods: We retrospectively reviewed the data of patient who had lymphocytic thyroitidis on FNA cytology of thyroid nodule from January 2005 to December 2010 at a tertiary referral hospital. In total, 109 patients with follow-up thyroid function tests (TFT) were enrolled...
March 13, 2018: Korean Journal of Internal Medicine
David L Diehl, Shaffer R S Mok, Harshit S Khara, Amitpal S Johal, H Lester Kirchner, Fan Lin
Background and study aims:  Endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) or biopsy (FNB) is an indispensable diagnostic tool. Improvements in needling technique have led to increasing tissue yields. Blood clogging of the needle can cause difficulties with specimen handling and stylet passage, which improves when the needle is primed with heparin before use. However, the effect of heparin on cytology, histology or immunochemistry (IHC) of FNA and FNB specimens is unknown...
March 2018: Endoscopy International Open
Yoon Suk Lee, Nam-Hoon Kim, Jun Hyuk Son, Jung Wook Kim, Won Ki Bae, Kyung-Ah Kim, June Sung Lee
Autoimmune pancreatitis (AIP) is a distinct subtype of pancreatitis, which is classified into type 1 and 2 based on the clinicopathological features. According to the international consensus diagnostic criteria, pancreas resection or core biopsy specimens are recommended to make an accurate histological evaluation. However, the usefulness of endoscopic ultrasonography (EUS) guided fine needle aspiration (FNA) for histological evaluation has also been reported. Furthermore, the simultaneous presentation of type 2 AIP and Crohn's disease (CD) is very rare, especially in the Asian population...
March 9, 2018: Internal Medicine
Michael J Levy, Benjamin R Kipp, Dragana Milosevic, Amber R Schneider, Jesse S Voss, Rajeswari Avula, Sarah E Kerr, Michael R Henry, Edward Highsmith, Minetta C Liu, Ferga C Gleeson
BACKGROUND & AIMS: Cellular and nuclear material from tumors disseminates into the bloodstream (tumoremia), but it is not clear whether medical procedures cause release of this material or contribute to formation of metastases. We performed a prospective study of blood samples from patients with pancreatic adenocarcinoma (PDAC) to determine whether endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) associates with markers of tumoremia. METHODS: We obtained peripheral blood from 104 patients (35 with PDAC) before and after EUS-FNA of primary tumors; blood samples from 69 healthy individuals were used as controls...
March 8, 2018: Clinical Gastroenterology and Hepatology
Yonghua Liu, Lin Yuan, Daohua Yang, Yubiao Jin
Medullary thyroid carcinoma (MTC) is potentially lethal. A prompt and accurate diagnosis is the prerequisite for the treatment of MTC. Fine-needle aspiration (FNA) is a reliable diagnostic tool in the assessment of thyroid nodules. However, cytologic assessment of MTC based on FNA has several drawbacks due to morphological variants. We present a case of MTC diagnosed through FNA cytology, which was eventually histologically confirmed as a mixed medullary-follicular carcinoma with negative serum calcitonin expression...
March 10, 2018: Diagnostic Cytopathology
Liron Pantanowitz, Lester D R Thompson, Esther Diana Rossi
Fine needle aspiration (FNA) has diagnostic and therapeutic value in the management of salivary gland cysts. Rendering an accurate diagnosis from an aspirated salivary gland cyst is challenging because of the broad differential diagnosis, possibility of sampling error, frequent hypocellularity of specimens, morphologic heterogeneity, and overlapping cytomorphology of many cystic entities. To date, there have been no comprehensive review articles providing a practical diagnostic approach to FNA of cystic lesions of salivary glands...
March 9, 2018: Head and Neck Pathology
Oscar V Hernández Mondragón, Juan M Velez Resendiz, Rodolfo R Ruiz
BACKGROUND AND AIMS: Pancreatic solid masses (PSM) are difficult to assess; endoscopic ultrasound with fine-needle aspiration (FNA) enables tissue acquisition, but has high false-negative rates. Quantitative elastography (QE) predicts diagnosis on the basis of the strain ratio (SR). We aimed to compare both methods to evaluate PSM. MATERIALS AND METHODS: This prospective study, carried out between January and December 2016, included suspected PSM cases; those with advanced disease and cystic components were excluded...
March 7, 2018: Journal of Clinical Gastroenterology
D Horadagoda, T Smith, W Varikatt
No abstract text is available yet for this article.
March 8, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
Sann Y Mon, Gregory Riedlinger, Collette E Abbott, Raja Seethala, N Paul Ohori, Marina N Nikiforova, Yuri E Nikiforov, Steven P Hodak
BACKGROUND: Thyroid-stimulating hormone receptor (TSHR) gene mutations play a critical role in thyroid cell proliferation and function. They are found in 20%-82% of hyperfunctioning nodules, hyperfunctioning follicular thyroid cancers (FTC), and papillary thyroid cancers (PTC). The diagnostic importance of TSHR mutation testing in fine needle aspiration (FNA) specimens remains unstudied. METHODS: To examine the association of TSHR mutations with the functional status and surgical outcomes of thyroid nodules, we evaluated 703 consecutive thyroid FNA samples with indeterminate cytology for TSHR mutations using next-generation sequencing...
March 8, 2018: Diagnostic Cytopathology
Louise Vølund Larsen, Alice Viktoria Egset, Camilla Holm, Stine Rosenkilde Larsen, Susanne Holm Nielsen, Jacob Bach, Jens Peter Helweg-Larsen, Jens Højberg Wanscher, Christian Godballe
INTRODUCTION: Fine-needle aspiration (FNA) is a cornerstone in diagnosing thyroid nodules. For decades, Danish FNA has been categorised into the groups: "FNA not performed", "Inadequate", "Cystic", "Inconclusive", "Benign", "Suspicious", "Malignant" and "Information missing". Internationally, The Bethesda Classification System (TBCS) is increasingly accepted, especially owing to a detailed specification of FNA suspicious for malignancy...
March 2018: Danish Medical Journal
Omer Basar, Osman Yuksel, Dennis Yang, Jason Samarasena, David Forcione, Christopher J DiMaio, Mihir S Wagh, Kenneth Chang, Brenna Casey, Carlos Fernandez-Del Castillo, Martha B Pitman, William R Brugge
BACKGROUND AND AIM: The tissue acquisition and diagnostic yield of cyst fluid cytology is low-to-moderate and rarely provides a specific diagnosis. The aim of this study was to compare the tissue acquisition and diagnostic tissue yield of micro-forceps biopsy (MFB) with cyst fluid cytology. PATIENTS AND METHODS: The data of 42 patients, whose cysts were aspirated by EUS-guided fine needle aspiration (EUS-FNA) and then biopsied with MFB device in this multicenter study, were collected...
March 3, 2018: Gastrointestinal Endoscopy
P W Shield, S J Crouch, D J Papadimos, M D Walsh
INTRODUCTION: We evaluated immunohistochemical staining for thyroid peroxidase (TPO), a glycoprotein found in the apical plasma membrane of thyroid follicular cells, as a marker for metastatic PTC in FNA samples and compared results with thyroglobulin (Tg) and thyroid transcription factor 1 (TTF1) staining. METHODS: Cell block sections prepared from 100 FNA specimens were stained with a rabbit monoclonal antibody to TPO (EP159). The FNAs included 64 metastatic malignancies from non-thyroid primary sites, including 18 lung, and 36 cases of thyroid tumours (29 PTC, six cases of medullary thyroid carcinoma and one thyroid anaplastic carcinoma)...
March 6, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
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