Read by QxMD icon Read


Alejandra Itzel González-Ramírez, Adrián Ramírez-Granillo, María Gabriela Medina-Canales, Aída Verónica Rodríguez-Tovar, María Angeles Martínez-Rivera
BACKGROUND: Biofilms are a highly structured consortia of microorganisms that adhere to a substrate and are encased within an extracellular matrix (ECM) that is produced by the organisms themselves. Aspergillus fumigatus is a biotechnological fungus that has a medical and phytopathogenic significance, and its biofilm occurs in both natural and artificial environments; therefore, studies on the stages observed in biofilm formation are of great significance due to the limited knowledge that exists on this specific topic and because there are multiple applications that are being carried out...
October 18, 2016: BMC Microbiology
Sara L Morales-Lázaro, Itzel Llorente, Félix Sierra-Ramírez, Ana E López-Romero, Miguel Ortíz-Rentería, Barbara Serrano-Flores, Sidney A Simon, León D Islas, Tamara Rosenbaum
The transient receptor potential vanilloid 1 (TRPV1) ion channel is mainly found in primary nociceptive afferents whose activity has been linked to pathophysiological conditions including pain, itch and inflammation. Consequently, it is important to identify naturally occurring antagonists of this channel. Here we show that a naturally occurring monounsaturated fatty acid, oleic acid, inhibits TRPV1 activity, and also pain and itch responses in mice by interacting with the vanilloid (capsaicin)-binding pocket and promoting the stabilization of a closed state conformation...
October 10, 2016: Nature Communications
Yuriko Itzel Sánchez-Zamora, Imelda Juarez-Avelar, Alicia Vazquez-Mendoza, Marcia Hiriart, Miriam Rodriguez-Sosa
Macrophage migration inhibitory factor (Mif) is highly expressed in type 1 diabetes mellitus (T1DM). However, there is limited information about how Mif influences the activation of macrophages (Mφ) and dendritic cells (DC) in T1DM. To address this issue, we induced T1DM by administering multiple low doses of streptozotocin (STZ) to Mif-/- or wild-type (Wt) BALB/c mice. We found that Mif-/- mice treated with STZ (Mif-/-STZ) developed lower levels of hyperglycemia, inflammatory cytokines, and specific pancreatic islet antigen- (PIAg-) IgG and displayed reduced cellular infiltration into the pancreatic islets compared to Wt mice treated with STZ (WtSTZ)...
2016: Journal of Diabetes Research
Daniel Cortés, Yolanda Robledo-Arratia, Ricardo Hernández-Martínez, Itzel Escobedo-Ávila, José Bargas, Iván Velasco
Embryonic stem cells (ESC) are pluripotent and thus can differentiate into every cell type present in the body. Directed differentiation into motor neurons (MNs) has been described for pluripotent cells. Although neurotrophic factors promote neuronal survival, their role in neuronal commitment is elusive. Here, we developed double-transgenic lines of mouse ESC (mESC) that constitutively produce glial cell line-derived neurotrophic factor (GDNF) and also contain a GFP reporter, driven by HB9, which is expressed only by postmitotic MNs...
2016: Frontiers in Cellular Neuroscience
Rosa Estela Quiroz-Castañeda, Itzel Amaro-Estrada, Sergio Darío Rodríguez-Camarillo
In order to understand the genetic diversity of A. marginale, several efforts have been made around the world. This rickettsia affects a significant number of ruminants, causing bovine anaplasmosis, so the interest in its virulence and how it is transmitted have drawn interest not only from a molecular point of view but also, recently, some genomics research have been performed to elucidate genes and proteins with potential as antigens. Unfortunately, so far, we still do not have a recombinant anaplasmosis vaccine...
2016: BioMed Research International
José Antonio Hernández-Trejo, Dimelza Lisett Suárez-Pérez, Itzel Zenidel Gutiérrez-Martínez, Omar E Fernandez-Vargas, Carolina Serrano, Aurora Antonia Candelario Martínez, Marco Antonio Meraz Ríos, Alí Francisco Citalán Madrid, Marcela Hernández Ruíz, Elba Reyes-Maldonado, Ricard Valle-Ríos, Jacobo Feintuch-Unger, Michael Schnoor, Nicolás Villegas-Sepúlveda, Oscar Medina Contreras, Porfirio Nava Domínguez
The gastrointestinal (GI) tract is the largest hormone-producing organ in the body due to a specialized cell population called enteroendocrine cells (EECs). The number of EECs increases in the mucosa of inflammatory bowel disease (IBD) patients; however, the mechanisms responsible for these changes remain unknown. Here, we show that the proinflammatory cytokines IFNγ and TNFα or DSS induced colitis increased the number of EECs producing Chromogranin A (CgA) in the colonic mucosa of C57BL/6J mice. CgA-positive cells were non-proliferating cells enriched with inactive PTEN and autophagy markers...
August 18, 2016: Biochemical Journal
Aideé Itzel Arcos-Martínez, Omar David Muñoz-Muñiz, Miguel Ángel Domínguez-Ortiz, Margarita Virginia Saavedra-Vélez, Maribel Vázquez-Hernández, María Gabriela Alcántara-López
OBJECTIVE: Argemone mexicana is a Papaveracea plant; some reports have shown their antibacterial, anti-cancer, sedative and probably anti-anxiety properties. From their aerial parts, flavonoids and alkaloids have been isolated, which are intrinsically related to some actions on the central nervous system. The aim of this study was to evaluate the anxiolytic-like effects of the plant, using its ethanolic extract and alkaloid-enriched extract obtained from fresh leaves. MATERIAL AND METHODS: Phytochemical screening was carried out together with evaluation of antioxidant capacity and the enrichment of alkaloids present in the extract...
July 2016: Avicenna Journal of Phytomedicine
Linda Gehrmann, Helena Bielak, Maximilian Behr, Fabian Itzel, Sven Lyko, Anne Simon, Gotthard Kunze, Elke Dopp, Martin Wagner, Jochen Tuerk
Endocrine-disrupting chemicals are mainly discharged into the environment by wastewater treatment plants (WWTPs) and are known to induce adverse effects in aquatic life. Advanced treatment with ozone successfully removes such organic micropollutants, but an increase of estrogenic effects after the ozonation of hospital wastewater was observed in previous studies. In order to investigate this effect, estrogenic and androgenic as well as anti-estrogenic and anti-androgenic activities were observed during treatment of hospital wastewater using three different effect-based reporter gene bioassays...
July 11, 2016: Environmental Science and Pollution Research International
Fernando Martínez-Ocampo, Sergio D Rodríguez-Camarillo, Itzel Amaro-Estrada, Rosa Estela Quiroz-Castañeda
We present here the draft genome sequence of the first "Candidatus Mycoplasma haemobos" strain found in cattle in Mexico. This hemotropic mycoplasma causes acute and chronic disease in animals. This genome is a starting point for studying the role of this mycoplasma in coinfections and synergistic mechanisms associated with the disease.
2016: Genome Announcements
Leonardo S Lino-Silva, Reynaldo Loaeza-Belmont, Miguel A Gómez Álvarez, Itzel Vela-Sarmiento, José M Aguilar-Romero, Jorge A Domínguez-Rodríguez, Rosa A Salcedo-Hernández, Erika B Ruiz-García, Héctor A Maldonado-Martínez, Ángel Herrera-Gómez
BACKGROUND: Most cases of rectal cancer (RC) in our institution are in pathologic stage T3. They are a heterogeneous group but have been classified in a single-stage category. We performed the present study to validate the prognostic significance of the mesorectal extension depth (MED) in T3 RC measured in millimeters beyond the muscularis propria plane. MATERIALS AND METHODS: We performed a retrospective analysis of 104 patients with T3 RC who had undergone curative surgery after a course of preoperative chemoradiotherapy at a tertiary referral cancer hospital...
June 8, 2016: Clinical Colorectal Cancer
Andreas Teufel, Timo Itzel, Wiebke Erhart, Mario Brosch, Xiao Yu Wang, Yong Ook Kim, Witigo von Schönfels, Alexander Herrmann, Stefan Brückner, Felix Stickel, Jean-François Dufour, Triantafyllos Chavakis, Claus Hellerbrand, Rainer Spang, Thorsten Maass, Thomas Becker, Stefan Schreiber, Clemens Schafmayer, Detlef Schuppan, Jochen Hampe
BACKGROUND & AIMS: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in industrialized countries. Mouse models of NAFLD have been used in studies of pathogenesis and treatment, and have certain features of the human disease. We performed a systematic transcriptome-wide analysis of liver tissues from patients at different stages of NAFLD progression (ranging from healthy obese individuals to those with steatosis), as well as rodent models of NAFLD, to identify those that most closely resemble human disease progression in terms of gene expression patterns...
September 2016: Gastroenterology
Araceli Diaz-Ruiz, Luis Antonio Tristán-López, Karen Itzel Medrano-Gómez, Juan Alejandro Torres-Domínguez, Camilo Ríos, Sergio Montes
OBJECTIVES: Lead exposure remains a significant environmental problem; lead is neurotoxic, especially in developing humans. In Mexico, lead in human blood is still a concern. Historically, much of the lead exposure is attributed to the use of handcrafted clay pottery for cooking, storing and serving food. However, experimental cause-and-effect demonstration is lacking. The present study explores this issue with a prospective experimental approach. METHODS: We used handcrafted clay containers to prepare and store lemonade, which was supplied as drinking water to pregnant rats throughout the gestational period...
June 14, 2016: Nutritional Neuroscience
Javier Aragón, Itzell Pérez Méndez
Due to high rates of complications, chest wall resection and reconstruction is a high risk procedure when large size of resection is required. Many different prosthetic materials have been used with similar results. Recently, thanks to the new advances in technology, personalized reconstruction have been possible with specific custom-made prosthesis. Nevertheless, they all generate certain amount of stiffness in thoracic motion because of his rigidity. In this report, we present a forward step in prosthesis design based on tridimensional titanium-printed technology...
June 2016: Journal of Thoracic Disease
Fernando Montes-Tapia, Antonio Rodríguez-Taméz, Idalia Cura-Esquivel, Itzel Barreto-Arroyo, Adolfo Hernández-Garduño, Isaías Rodríguez-Balderrama, José Quero, Manuel de la O-Cavazos
BACKGROUND: Central venous catheterization is not the first choice of vascular access in neonates. Success depends on the size of the vessel and the skill of the health professional performing the procedure. The internal jugular vein provides a predictable path for central venous cannulation, although it is more difficult to cannulate infants than adults and even more difficult in smaller newborns. METHODS: We conducted a prospective study in 100 newborns, in which a 4 Fr ultrasound-guided central venous catheter was placed in the right internal jugular vein (RIJV)...
October 2016: Journal of Pediatric Surgery
Arturo Jiménez-Sánchez, Itzel Isunza-Manrique, Gabriel Ramos-Ortiz, Jesús Rodríguez-Romero, Norberto Farfán, Rosa Santillan
Design parameters derived from structure-property relationships play a very important role in the development of efficient molecular-based functional materials with optical properties. Here, we report on the linear and nonlinear optical properties of a fluorene-derived dipolar system (DS) and its octupolar analogue (OS), in which donor and acceptor groups are connected by a phenylacetylene linkage, as a strategy to increase the number of delocalized electrons in the π-conjugated system. The optical nonlinear response was analyzed in detail by experimental and theoretical methods, showing that, in the octupolar system OS, the dipolar effects induced a strong two-photon absorption process whose magnitude is as large as 2210 GM at infrared wavelengths...
June 30, 2016: Journal of Physical Chemistry. A
Irene Vergara, Erick Y Castillo, Mario E Romero-Piña, Itzel Torres-Viquez, Dayanira Paniagua, Leslie V Boyer, Alejandro Alagón, Luis Alberto Medina
The venom of the Eastern coral snake Micrurus fulvius can cause respiratory paralysis in the bitten patient, which is attributable to β-neurotoxins (β-NTx). The aim of this work was to study the biodistribution and lymphatic tracking by molecular imaging of the main β-NTx of M. fulvius venom. β-NTx was bioconjugated with the chelator diethylenetriaminepenta-acetic acid (DTPA) and radiolabeled with the radionuclide Gallium-67. Radiolabeling efficiency was 60%-78%; radiochemical purity ≥92%; and stability at 48 h ≥ 85%...
April 2016: Toxins
Benjamin J Moyer, Itzel Y Rojas, Joanna S Kerley-Hamilton, Haley F Hazlett, Krishnamurthy V Nemani, Heidi W Trask, Rachel J West, Leslie E Lupien, Alan J Collins, Carol S Ringelberg, Barjor Gimi, William B Kinlaw, Craig R Tomlinson
Obesity is an increasingly urgent global problem, yet, little is known about its causes and less is known how obesity can be effectively treated. We showed previously that the aryl hydrocarbon receptor (AHR) plays a role in the regulation of body mass in mice fed Western diet. The AHR is a ligand-activated nuclear receptor that regulates genes involved in a number of biological pathways, including xenobiotic metabolism and T cell polarization. This study was an investigation into whether inhibition of the AHR prevents Western diet-based obesity...
June 1, 2016: Toxicology and Applied Pharmacology
Abraham Wall-Medrano, Arnulfo Ramos-Jiménez, Rosa P Hernandez-Torres, Rafael Villalobos-Molina, Diana C Tapia-Pancardo, J Rafael Jiménez-Flores, A René Méndez-Cruz, Miguel Murguía-Romero, Itzell A Gallardo-Ortíz, René Urquídez-Romero
BACKGROUND: A body mass index (BMI) ≥30 kg/m(2) and a waist circumference (WC) ≥80 cm in women (WCF) or ≥90 cm in men (WCM) are reference cardiometabolic risk markers (CMM) for Mexicans adults. However, their reliability to predict other CMM (index tests) in young Mexicans has not been studied in depth. METHODS: A cross-sectional descriptive study evaluating several anthropometric, physiological and biochemical CMM from 295 young Mexicans was performed. Sensitivity (Se), specificity (Sp) and Youden's index (J) of reference BMI/WC cutoffs toward other CMM (n = 14) were obtained and their most reliable cutoffs were further calculated at Jmax...
2016: BMC Public Health
Anna Etzold, Danuta Galetzka, Eva Weis, Oliver Bartsch, Thomas Haaf, Claudia Spix, Timo Itzel, Susann Schweiger, Dennis Strand, Susanne Strand, Ulrich Zechner
Constitutive epimutations of tumor suppressor genes are increasingly considered as cancer predisposing factors equally to sequence mutations. In light of the emerging role of the microenvironment for cancer predisposition, initiation, and progression, we aimed to characterize the consequences of a BRCA1 epimutation in cells of mesenchymal origin. We performed a comprehensive molecular and cellular comparison of primary dermal fibroblasts taken from a monozygous twin pair discordant for recurrent cancers and BRCA1 epimutation, whose exceptional clinical case we previously reported in this journal...
2016: Epigenetics: Official Journal of the DNA Methylation Society
Joel Vega-Badillo, Roxana Gutiérrez-Vidal, Hugo A Hernández-Pérez, Hugo Villamil-Ramírez, Paola León-Mimila, Fausto Sánchez-Muñoz, Sofía Morán-Ramos, Elena Larrieta-Carrasco, Itzel Fernández-Silva, Nahúm Méndez-Sánchez, Armando R Tovar, Francisco Campos-Pérez, Teresa Villarreal-Molina, Rogelio Hernández-Pando, Carlos A Aguilar-Salinas, Samuel Canizales-Quinteros
BACKGROUND AND AIM: Abnormal cholesterol metabolism may contribute to the pathogenesis of non-alcoholic steatohepatitis (NASH) and fibrosis. miR-33 and miR-144 regulate adenosine triphosphate binding cassette transporter (ABCA1) and other target genes involved in cholesterol efflux, fatty acid oxidation and inflammation. We explored relationships between non-alcoholic fatty liver disease (NAFLD) and the hepatic expression of ABCA1/ABCG1, as well as other target genes regulated by miR-33 (carnitine O-octanoyltransferase, CROT and hydroxyacyl-CoA-dehydrogenase β-subunit, HADHB) and miR-144 (toll-like receptor-2, TLR2)...
September 2016: Liver International: Official Journal of the International Association for the Study of the Liver
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"