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REVIEW
Thelma Beatriz González-Castro, Itzel Rodríguez-Fuentes, Carlos Alfonso Tovilla-Zárate, Isela Esther Juárez-Rojop, Yazmín Hernández-Díaz, María Lilia López-Narváez, Edith Elena Uresti-Rivera, Jorge Luis Hernández-Vicencio
Genes involved in the hypothalamic-pituitary-adrenal axis may be a robust biomarker of psychiatric disorders. Genetic polymorphisms of the SKA2 gene are associated with several behavioral disorders. In this study, we embarked on a systematic search of all possible reports of genetic association with SKA2 and affective disorder, post-traumatic stress disorder, and suicide behavior; the functional consequences of nsSNPs were explored through computational tools with an in silico analysis. Eight eligible articles were included...
May 9, 2024: Metabolic Brain Disease
#2
JOURNAL ARTICLE
Itzel C Núñez-García, Guillermo Cristian G Martínez-Ávila, Silvia M González-Herrera, Julio C Tafolla-Arellano, O Miriam Rutiaga-Quiñones
Endophytic microbial communities colonize plants growing under various abiotic stress conditions. Candelilla (Euphorbia antisyphilitica Zucc.) is a shrub that develops functionally in arid and semi-arid zones of Mexico; these conditions generate an association between the plant and the microorganisms, contributing to the production of enzymes as a defense mechanism for resistance to abiotic stress. The objective of this research was to isolate and identify endophyte fungi of candelilla and bioprospection of these endophytic fungi for enzyme production using candelilla by-products...
May 7, 2024: Journal of Basic Microbiology
#3
JOURNAL ARTICLE
Saira Itzel Colmenares-Cuevas, Adriana Contreras-Oliva, Josafhat Salinas-Ruiz, Juan Valente Hidalgo-Contreras, Enrique Flores-Andrade, Edgar Jesús García-Ramírez
Consumer demand for healthier confectionery products has prompted the confectionery industry to create products that are reduced in sugar content and supplemented with vitamins, antioxidants or biological elements beneficial to health. The aim of this study was to develop marshmallows enriched with Apis mellifera honey and Lactobacillus rhamnosus and to evaluate the effect of honey concentration and gelatin bloom degrees on marshmallow properties. A completely randomized design with a factorial structure was applied with different honey concentrations (0, 50 and 75%) and at different gelatin bloom degrees (265, 300 and 315 bloom degrees); moreover, the physicochemical properties, total phenol content and antioxidant activity of the marshmallow were studied, as well as the viability of the probiotic...
2024: Frontiers in Nutrition
#4
JOURNAL ARTICLE
José Luis Rodríguez-Mejía, Itzel Anahí Hidalgo-Manzano, Luis Felipe Muriel-Millán, Nancy Rivera-Gomez, Diana X Sahonero-Canavesi, Edmundo Castillo, Liliana Pardo-López
Marine environments harbor a plethora of microorganisms that represent a valuable source of new biomolecules of biotechnological interest. In particular, enzymes from marine bacteria exhibit unique properties due to their high catalytic activity under various stressful and fluctuating conditions, such as temperature, pH, and salinity, fluctuations which are common during several industrial processes. In this study, we report a new esterase (EstGoM) from a marine Pseudomonas sp. isolated at a depth of 1000 m in the Gulf of Mexico...
May 1, 2024: Marine Biotechnology
#5
JOURNAL ARTICLE
Itzel Yoselin Sánchez-Perez, Yareni Chávez-Ríos, Sergio Gerardo Moreno-Hernández, Andrea Velasco-Medina, Guillermo Velázquez-Sámano, Espiridión Ramos-Martínez
BACKGROUND: Loxoscelism is a toxic clinical condition caused by the bite of spiders of the genus Loxosceles , with wide distribution throughout the world.1 Phospholipase D is responsible for dermonecrosis, inflammation, platelet aggregation, hemolysis, alteration of vascular permeability, cytotoxicity, nephrotoxicity, acute renal failure, among other symptoms involved with this protein. CASE REPORT: 27-year-old male patient, who began with a sudden episode of intense pain in the right hand, in the metacarpus and metacarpophalangeal joints...
February 1, 2024: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
#6
JOURNAL ARTICLE
Bryan Eduardo García-López, Diana Mondragón-García, Abigail Morán-Domínguez, Itzel Yoselin Sánchez-Pérez, Guillermo Velázquez-Sámano, Andrea Aida Velasco-Medina
BACKGROUND: The first report of cerebrospinal fluid rhinorrhea (CSFR) was described in 1679. In 1826 it was reported that one of the possible causes of CSFR was a fistula between the subarachnoid space and the nasal cavity. In 1903, chemical analysis of the fluid was proposed as a diagnostic criterion. In Mexico there has been 32 case reports. CASE REPORT: Forty-nine years old female with a history of nasal polyposis, profuse rhinorrhea and cephalea who attends the allergy department with the suspicion of allergic rhinitis...
February 1, 2024: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
#7
JOURNAL ARTICLE
Erick J Rodríguez-Palma, Ana M Islas-Espinoza, Itzel I Ramos-Rodríguez, Juan Miguel Pizaña-Encarnación, Miguel Á Gutiérez-Agredano, Ciciolil Morales-Moreno, Alonso Fernández-Guasti, Vinicio Granados-Soto
The purpose of this study was to investigate the mechanisms underlying sex differences in the role of spinal α6 -subunit containing GABAA (α6 GABAA ) receptors in rats with neuropathic pain. Intrathecal 2,5-dihydro-7-methoxy-2-(4-methoxyphenyl)-3H-pyrazolo [4,3-c] quinoline-3-one (PZ-II-029, positive allosteric modulator of α6 GABAA receptors) reduced tactile allodynia in female but not in male rats with neuropathic pain. PZ-II-029 was also more effective in females than males in inflammatory and nociplastic pain...
April 26, 2024: European Journal of Pharmacology
#8
MULTICENTER STUDY
Valeria Fabre, Sara E Cosgrove, Fernanda C Lessa, Twisha S Patel, Guadalupe Reyes-Morales, Washington R Aleman, Andrea Alvarado Alvarez, Bowen Aquiles, Ana B Arauz, Facundo Arguello, Maria Fernanda Barberis, Laura Barcan, Maria P Bernachea, Marisa L Bernan, Carlos Buitrago, Maria Del Carmen Bangher, Ximena Castañeda, Angel M Colque, Alfredo Canton, Rosa Contreras, Silvia Correa, Gustavo Costilla Campero, Lidia Espinola, Clara Esquivel, Cecilia Ezcurra, Leandro A Falleroni, Johana Fernandez, Sandra Ferrari, Natalia Frassone, Carlos Garcia Cruz, Maria Isabel Garzón, Carlos H Gomez Quintero, José A Gonzalez, Lucrecia Guaymas, Fausto Guerrero-Toapanta, Sandra Lambert, Diego Laplume, Paola R Lazarte, César G Lemir, Angelica Lopez, Itzel L Lopez, Herberth Maldonado, Guadalupe Martinez, Diego M Maurizi, Mario Melgar, Florencia Mesplet, Carlos Morales Pertuz, Cristina Moreno, Gabriela L Moya, Yanina Nuccetelli, Glendys Núñez, Carolina Osuna, Belén Palacio, Florencia Pellice, Carla Raffo, Fanny Reino Choto, Gerardo Ricoy, Viviana Rodriguez, Federico Romero, Juan J Romero, Maria Eugenia Russo, Graciela Sadino, Nancy Sandoval, Mirta G Silva, Alejandra M Urueña, Ligia Vence Reyes, Hugo Videla, Marisol Valle, Silvia Vera Amate Perez, Hernan Vergara-Samur, Silvina Villamandos, Olmedo Villarreal, Alejandra Viteri, Eduardo Warley, Rodolfo E Quiros
BACKGROUND: The burden of antimicrobial resistance (AMR) in Latin America is high. Little is known about healthcare workers' (HCWs) knowledge, attitudes, and perceptions of antimicrobial stewardship (AS), AMR, and antibiotic use (AU) in the region. METHODS: HCWs from 42 hospitals from 5 Latin American countries were invited to take an electronic, voluntary, anonymous survey regarding knowledge, attitudes, and perceptions of AS, AMR, and AU between March-April 2023...
April 26, 2024: Antimicrobial Resistance and Infection Control
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JOURNAL ARTICLE
Itzell Hernández-Sánchez, Tobias Rindfleisch, Jessica Alpers, Martin Dulle, Christopher J Garvey, Patrick Knox-Brown, Markus S Miettinen, Gergely Nagy, Julio M Pusterla, Agata Rekas, Keyun Shou, Andreas M Stadler, Dirk Walther, Martin Wolff, Ellen Zuther, Anja Thalhammer
Intrinsically disordered late embryogenesis abundant (LEA) proteins play a central role in the tolerance of plants and other organisms to dehydration brought upon, for example, by freezing temperatures, high salt concentration, drought or desiccation, and many LEA proteins have been found to stabilize dehydration-sensitive cellular structures. Their conformational ensembles are highly sensitive to the environment, allowing them to undergo conformational changes and adopt ordered secondary and quaternary structures and to participate in formation of membraneless organelles...
May 2024: Protein Science
#10
JOURNAL ARTICLE
Itzel Jatziri Contreras-García, Cindy Bandala, Iván Ignacio-Mejía, Luz Adriana Pichardo-Macías, Julieta Griselda Mendoza-Torreblanca, Mercedes Edna García-Cruz, Saúl Gómez-Manzo, Noemí Cárdenas-Rodríguez
Levetiracetam (LEV) is a drug commonly used as an anticonvulsant. However, recent evidence points to a possible role as an antioxidant. We previously demonstrated the antioxidant properties of LEV by significantly increasing catalase and superoxide dismutase activities and decreasing the hydrogen peroxide (H2O2) levels in the hippocampus of rats with temporal lobe epilepsy (TLE) showing scavenging properties against the hydroxyl radical. The aim of the present work was to evaluate, the effect of LEV on DNA oxidation, by determining 8‑hydroxy‑2‑deoxyguanosine (8‑OHdG) levels, and glutathione content, through reduced (GSH) and oxidized (GSSG) glutathione levels, in the hippocampus of rats with TLE...
March 28, 2024: Acta Neurobiologiae Experimentalis
#11
JOURNAL ARTICLE
Marco Espina-Ordoñez, Yalbi Itzel Balderas-Martínez, Ana Lilia Torres-Machorro, Iliana Herrera, Mariel Maldonado, Yair Romero, Fernanda Toscano-Marquez, Annie Pardo, Moisés Selman, José Cisneros
BACKGROUND: Hypersensitivity pneumonitis (HP) is an inflammatory disorder affecting lung parenchyma and often evolves into fibrosis (fHP). The altered regulation of genes involved in the pathogenesis of the disease is not well comprehended, while the role of microRNAs in lung fibroblasts remains unexplored. METHODS: We used integrated bulk RNA-Seq and enrichment pathway bioinformatic analyses to identify differentially expressed (DE)-miRNAs and genes (DEGs) associated with HP lungs...
September 2024: Non-Coding RNA Research
#12
JOURNAL ARTICLE
Itzel Santiago-Figueroa, Manases González-Cortazar, Julieta Gertrudis Estrada-Flores, Jorge Alfredo Cuéllar-Ordaz, María Eugenia López-Arellano, Francisco Javier González-Reyes, Agustín Olmedo-Juárez, Rosa Isabel Higuera-Piedrahita
PURPOSE: We analysed the possible synergistic activity among active extracts from Artemisia cina and Tagetes lucida combinations on Haemonchus contortus, a nematode parasitising sheep. METHODS: The work was carried out in vitro on eggs and infective larvae (L3) of H. contortus. The results were analysed with SAS 9.1, applying the ANOVA and Tukey test, and the lethal concentration (LC) values LC50 and LC90 were determined with regression analysis, employing Proc Probit of SAS 9...
April 3, 2024: Acta Parasitologica
#13
REVIEW
Octavio Daniel Reyes-Hernández, Gabriela Figueroa-González, Laura Itzel Quintas-Granados, Hector Hernández-Parra, Sheila I Peña-Corona, Hernán Cortés, Aliya Kipchakbayeva, Zhazira Mukazhanova, Solomon Habtemariam, Gerardo Leyva-Gómez, Dietrich Büsselberg, Javad Sharifi-Rad
Icaritin is a natural prenylated flavonoid derived from the Chinese herb Epimedium. The compound has shown antitumor effects in various cancers, especially hepatocellular carcinoma (HCC). Icaritin exerts its anticancer activity by modulating multiple signaling pathways, such as IL-6/JAK/STAT3, ER-α36, and NF-κB, affecting the tumor microenvironment and immune system. Several clinical trials have evaluated the safety and efficacy of icaritin in advanced HCC patients with poor prognoses, who are unsuitable for conventional therapies...
April 2024: Drug Development Research
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JOURNAL ARTICLE
María Guadalupe Salinas-Juárez, Saira Itzel Ortiz-Zamora, Pedro Roquero-Tejeda, Francisco Javier Garfias-Vásquez, María Del Carmen Durán-Domínguez-de-Bazúa
A proton exchange membrane increases the electrical performance of a microbial fuel cell (MFC). New inexpensive materials should be sought, especially in a constructed wetland microbial fuel cell (CW-MFC). Here, in a laboratory-scale system of five CW-MFCs, wet clay, wet earth or mud, and non-woven cloth were used as inexpensive separators with long-term stability. The five CW-MFCs were planted with Typha latifolia , fed with synthetic wastewater, and packed with natural porous material. Graphite felt was used as electrodes and the experimental system had a hydraulic residence time of 3 days, operating under shade and natural conditions of temperature and light...
April 2, 2024: International Journal of Phytoremediation
#15
JOURNAL ARTICLE
Angela Caro-Borrero, Kenia Márquez-Santamaria, Javier Carmona-Jiménez, Itzel Becerra-Absalón, Elvira Perona
Cyanobacteria inhabiting lotic environments have been poorly studied and characterized in Mexico, despite their potential risks from cyanotoxin production. This article aims to fill this knowledge gap by assessing the importance of benthic cyanobacteria as potential cyanotoxin producers in central Mexican rivers through: (i) the taxonomic identification of cyanobacteria found in these rivers, (ii) the environmental characterization of their habitats, and (iii) testing for the presence of toxin producing genes in the encountered taxa...
April 2, 2024: Environmental Monitoring and Assessment
#16
JOURNAL ARTICLE
Ilse Domínguez-Alemán, Itzel Domínguez-Alemán, Juan Carlos Hernández-Gómez, Francisco J Ariza-Hernández
In this paper, we study a generalized eco-epidemiological model of fractional order for the predator-prey type in the presence of an infectious disease in the prey. The proposed model considers that the disease infects the prey, causing them to be divided into two classes, susceptible prey and infected prey, with different density-dependent predation rates between the two classes. We propose logistic growth in both the prey and predator populations, and we also propose that the predators have alternative food sources (i...
February 18, 2024: Mathematical Biosciences and Engineering: MBE
#17
JOURNAL ARTICLE
Janina Lara Gerber, Suria Itzel Morales Guzmán, Lorenz Worf, Petra Hubbe, Jürgen Kopp, Jirka Peschek
RNA ligases of the RTCB-type play an essential role in tRNA splicing, the unfolded protein response and RNA repair. RTCB is the catalytic subunit of the pentameric human tRNA ligase complex. RNA ligation by the tRNA ligase complex requires GTP-dependent activation of RTCB. This active site guanylylation reaction relies on the activation factor Archease. The mechanistic interplay between both proteins has remained unknown. Here, we report a biochemical and structural analysis of the human RTCB-Archease complex in the pre- and post-activation state...
March 16, 2024: Nature Communications
#18
REVIEW
Nosheen Malak, Sadaf Niaz, Estefan Miranda-Miranda, Raquel Cossío-Bayúgar, Jonny Edward Duque, Itzel Amaro-Estrada, Nasreen Nasreen, Adil Khan, Joanna Kulisz, Zbigniew Zając
Ticks and tick-borne diseases have gained increasing attention in recent years due to their impact on public health and significant losses in livestock production. The use of synthetic compounds for tick control is becoming problematic, mainly due to the resistance to commercially available products as well as their toxicity. Therefore, new alternative control methods are required. For this purpose, plant-derived extracts may be considered as effective repellents and/or acaricides. The present literature review focuses on studies evaluating the acaricidal and repellent activity of plant-derived extracts and plant secondary metabolites...
March 15, 2024: Experimental & Applied Acarology
#19
JOURNAL ARTICLE
Eduardo Liquidano-Perez, Mariana Carmona Berrón, Rosa Itzel Carrillo Nieto, Celso Tomás Corcuera Delgado, Lizbeth Blancas Galicia, Selma Cecilia Scheffler Mendoza
Chronic granulomatous disease (CGD) presents with granuloma formation and lethal infections. It is inherited in an autosomal or X-linked recessive pattern. We describe a 10-month-old patient with a fatal secondary HLH as a CGD primary manifestation. We carried out an autopsy and found noncaseating granulomas, an aspergilloma in the lung, and hemophagocytosis. We performed a DHR assay on the patient's mother and grandmother, showing a bimodal pattern conclusive of X-linked CGD. Thus, our definitive diagnosis was CGD complicated by macrophage activation syndrome...
December 28, 2023: Iranian Journal of Allergy, Asthma, and Immunology
#20
REVIEW
Reyna Sámano, Hugo Martínez-Rojano, Gabriela Chico-Barba, Ricardo Gamboa, María Eugenia Mendoza-Flores, Francisco Javier Robles-Alarcón, Itzel Pérez-Martínez, Irma Eloisa Monroy-Muñoz
Excessive or insufficient gestational weight gain (GWG) leads to diverse adverse maternal and neonatal outcomes. There is evidence that pregestational body mass index (pBMI) plays a role in GWG, but no genetic cause has been identified. In this review, we aim to analyze genotype variants associated with GWG. Results: We identified seven genotype variants that may be involved in GWG regulation that were analyzed in studies carried out in Brazil, Romania, the USA, Turkey, Ukraine, and Canada. Some genetic variants were only associated with GWG in certain races or depending on the pBMI...
March 6, 2024: International Journal of Molecular Sciences
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