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Dhuha Al-Sajee, Roma Sehmi, Thomas J Hawke, Amani El-Gammal, Karen J Howie, Richard M Watson, Marco Londei, Gail M Gauvreau, Paul M O'Byrne
No abstract text is available yet for this article.
May 7, 2018: American Journal of Respiratory and Critical Care Medicine
Nawaf Al Mutairi, Dhuha Alrqobah, Nasser Haji Hussain
Association of childhood psoriasis with metabolic syndrome has not been studied well. TNF-alfa contributes to the inflammation seen in metabolic syndrome, and recently etanercept has shown to reduce the levels of inflammatory markers. Assessment of prevalence of metabolic syndrome in juvenile psoriasis patients in Kuwait. We included 236 patients with moderate to severe psoriasis below 18 years treated for at least 24 weeks with TNF inhibitors (Group A), and equal number of age and sex matched cases treated with conventional medications (Group B)...
January 2018: Dermatologic Therapy
Dhuha Al-Sajee, John-Paul Oliveria, Roma Sehmi, Gail M Gauvreau
PURPOSE OF REVIEW: Recent studies have highlighted the role of alarmins in asthma pathophysiology and tested the roles of these cytokines in asthmatic patients. This review will discuss the recent advances in the role of alarmins in asthma and the potential of future targeted therapies in asthma. RECENT FINDINGS: Epithelial-derived cytokines can be released upon exposure to external stimuli, causing damage to the epithelial barrier and resulting in tissue inflammation...
January 2018: Current Opinion in Pulmonary Medicine
Dhuha Alwan, Esther Chipps, Po-Yin Yen, Kathleen Dungan
AIMS: The objective of this study was to examine the relationship between measures of coordinated insulin delivery and capillary blood glucose (CBG) levels among hospitalized patients and to assess nurse perceptions of insulin administration. METHODS: Hospitalized patients (n=451) receiving rapid acting insulin analog (RAIA) using carbohydrate counting were retrospectively analyzed. Nurses (n=35) were asked to complete an 18-item anonymous survey assessing perception of RAIA dosing...
September 2017: Diabetes Research and Clinical Practice
Nadia M Fida, Mohammed Farouq, Dhuha Alamawi, Hayat Kamfar
AIM: This study aimed to evaluate fifth-year medical students' perception of their learning experience during pediatric rotation at the medical college of King Abdulaziz University (KAU), Jeddah, Saudi Arabia. METHOD: This cross-sectional study was conducted by distributing a questionnaire to fifth-year students who attended the pediatric rotation at KAU, during 2013-2014. RESULTS: Three hundred fifty-six out of 360 students agreed to participate, representing a response rate of 99%...
March 10, 2017: Medical Teacher
Sara J Healy, Haikady N Nagaraja, Dhuha Alwan, Kathleen M Dungan
To determine prevalence, predictors, and outcomes of steroid-induced hyperglycemia in hospitalized patients with hematologic malignancies METHODS: We performed retrospective analysis of patients who were hospitalized on any of the four hematology services or bone marrow transplant service and who received systemic steroids during a 2-month period. Mean glucoses for days 1-4 and maximum glucose were calculated and the total daily steroid dose was converted to equivalent dose of dexamethasone. Hyperglycemia was defined as any glucose >9...
April 2017: Endocrine
Eric Gluck, Dhuha Maki
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
Dhuha Tarik Nassar, Omran S Habib, Abbas Ali Mansour
AIM: To measure the incidence and determinants (predictors) of hypoglycemia among patients with type 2 diabetes mellitus (T2DM) who were on insulin treatment for at least one year. METHODS: The present study is an out-patients based inquiry about the risk and predictors of hypoglycemia among patients with T2DM seeking care at the Al-Faiha Specialized Diabetes, Endocrine, and Metabolism Center, in Basrah over a period of 7 mo (from 15(th) of April, 2013 to 15(th) of October, 2013)...
October 15, 2016: World Journal of Diabetes
Manhal Izzy, Kinesh Changela, Dhuha Alhankawi, Nami Safai Haeri, Sulay Shah, Ghalib Jibara, Sury Anand, Shashideep Singhal
BACKGROUND: The negative effect of diabetes mellitus (DM) on the colonoscopy preparation has been previously established. Metabolic syndrome has been shown to increase risk for malignancy and possibly for premalignant lesions. This study aimed to investigate the impact of DM control on colonoscopy outcomes including bowel preparation and adenoma detection rate (ADR). METHODS: We included patients with DM who underwent colonoscopy in our hospital and had a documented glycated hemoglobin (HbA1C) within 3 months...
July 2016: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
Donna M D'Souza, Sarah Zhou, Irena A Rebalka, Blair MacDonald, Jasmin Moradi, Matthew P Krause, Dhuha Al-Sajee, Zubin Punthakee, Mark A Tarnopolsky, Thomas J Hawke
Type 1 diabetes (T1D) negatively influences skeletal muscle health; however, its effect on muscle satellite cells (SCs) remains largely unknown. SCs from samples from rodents (Akita) and human subjects with T1D were examined to discern differences in SC density and functionality compared with samples from their respective control subjects. Examination of the Notch pathway was undertaken to investigate its role in changes to SC functionality. Compared with controls, Akita mice demonstrated increased muscle damage after eccentric exercise along with a decline in SC density and myogenic capacity...
October 2016: Diabetes
Salwan Yousif Hanna Bede, Waleed Khaleel Ismael, Dhuha Al-Assaf
Facial trauma in children and adolescents is reported to range from 1% to 30%. Because of many anatomical, physiological, and psychological characteristics of the pediatric population, maxillofacial injuries in children should be treated with special consideration that is attributable to certain features inherent in facial growth patterns of children. This study evaluated maxillofacial injuries in 726 children in terms of incidence, patterns of injury, causes, and treatment modalities and compared these parameters among 3 pediatric age groups...
May 2016: Journal of Craniofacial Surgery
Kinesh Changela, Dhuha Alhankawi, Sury Anand, Mahesh Krishnaiah
No abstract text is available yet for this article.
April 2016: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
Amani El-Gammal, John-Paul Oliveria, Karen Howie, Richard Watson, Patrick Mitchell, Ruchong Chen, Adrian Baatjes, Steven Smith, Dhuha Al-Sajee, Thomas J Hawke, Kieran J Killian, Gail M Gauvreau, Paul M O'Byrne
RATIONALE: Dendritic cells (DCs) are antigen-presenting cells essential for the initiation of T-cell responses. Allergen inhalation increases the number of airway DCs and the release of epithelial-derived cytokines, such as IL-33 and thymic stromal lymphopoietin (TSLP), that activate DCs. OBJECTIVES: To examine the effects of inhaled allergen on bone marrow production of DCs and their trafficking into the airways in subjects with allergic asthma, and to examine IL-33 and TSPL receptor expression on DCs...
July 15, 2016: American Journal of Respiratory and Critical Care Medicine
Donna M D'Souza, Karin E Trajcevski, Dhuha Al-Sajee, David C Wang, Melissa Thomas, Judy E Anderson, Thomas J Hawke
A healthy skeletal muscle mass is essential in attenuating the complications of obesity. Importantly, healthy muscle function is maintained through adequate repair following overuse and injury. The purpose of this study was to investigate the impact of diet-induced obesity (DIO) on skeletal muscle repair and the functionality of the muscle satellite cell (SC) population. Male C57BL/6J mice were fed a standard chow or high-fat diet (60% kcal fat; DIO) for 8 weeks. Muscles from DIO mice subjected to cardiotoxin injury displayed attenuated muscle regeneration, as indicated by prolonged necrosis, delayed expression of MyoD and Myogenin, elevated collagen content, and persistent embryonic myosin heavy chain expression...
August 2015: Physiological Reports
Daniel J O'Neill, Stuart Charles Williamson, Dhuha Alkharaif, Isabella Christina Mazzaro Monteiro, Marilyn Goudreault, Luke Gaughan, Craig N Robson, Anne-Claude Gingras, Olivier Binda
The lysine methyltransferase SETD6 modifies the histone variant H2AZ, a key component of nuclear receptor-dependent transcription. Herein, we report the identification of several factors that associate with SETD6 and are implicated in nuclear hormone receptor signaling. Specifically, SETD6 associates with the estrogen receptor α (ERα), histone deacetylase HDAC1, metastasis protein MTA2, and the transcriptional co-activator TRRAP. Luciferase reporter assays identify SETD6 as a transcriptional repressor, in agreement with its association with HDAC1 and MTA2...
July 2014: Epigenetics: Official Journal of the DNA Methylation Society
Donna M D'Souza, Dhuha Al-Sajee, Thomas J Hawke
Diabetes mellitus is defined as a group of metabolic diseases that are associated with the presence of a hyperglycemic state due to impairments in insulin release and/or function. While the development of each form of diabetes (Type 1 or Type 2) drastically differs, resultant pathologies often overlap. In each diabetic condition, a failure to maintain healthy muscle is often observed, and is termed diabetic myopathy. This significant, but often overlooked, complication is believed to contribute to the progression of additional diabetic complications due to the vital importance of skeletal muscle for our physical and metabolic well-being...
December 20, 2013: Frontiers in Physiology
Mats I Nilsson, Aliyah A Nissar, Dhuha Al-Sajee, Mark A Tarnopolsky, Gianni Parise, Boleslav Lach, Dieter O Fürst, Peter F M van der Ven, Rudolf A Kley, Thomas J Hawke
Xin is a striated muscle-specific protein that is localized to the myotendinous junction in skeletal muscle. However, in injured mouse muscle, Xin expression is up-regulated and observed throughout skeletal muscle fibers and within satellite cells. In this study, Xin was analyzed by immunofluorescent staining in skeletal muscle samples from 47 subjects with various forms of myopathy, including muscular dystrophies, inflammatory myopathies, mitochondrial/metabolic myopathy, and endocrine myopathy. Results indicate that Xin immunoreactivity is positively and significantly correlated (rs = 0...
December 2013: American Journal of Pathology
Karin E Trajcevski, Hayley M O'Neill, David C Wang, Melissa M Thomas, Dhuha Al-Sajee, Gregory R Steinberg, Rolando B Ceddia, Thomas J Hawke
BACKGROUND: Diet-induced obesity is a rising health concern which can lead to the development of glucose intolerance and muscle insulin resistance and, ultimately, type II diabetes mellitus. This research investigates the associations between glucose intolerance or muscle insulin resistance and tissue specific changes during the progression of diet-induced obesity. METHODOLOGY: C57BL/6J mice were fed a normal or high-fat diet (HFD; 60% kcal fat) for 3 or 8 weeks...
2013: PloS One
Matthew P Krause, Dhuha Al-Sajee, Donna M D'Souza, Irena A Rebalka, Jasmin Moradi, Michael C Riddell, Thomas J Hawke
BACKGROUND: Systemic elevations in PAI-1 suppress the fibrinolytic pathway leading to poor collagen remodelling and delayed regeneration of tibialis anterior (TA) muscles in type-1 diabetic Akita mice. However, how impaired collagen remodelling was specifically attenuating regeneration in Akita mice remained unknown. Furthermore, given intrinsic differences between muscle groups, it was unclear if the reparative responses between muscle groups were different. PRINCIPAL FINDINGS: Here we reveal that diabetic Akita muscles display differential regenerative responses with the TA and gastrocnemius muscles exhibiting reduced regenerating myofiber area compared to wild-type mice, while soleus muscles displayed no difference between animal groups following injury...
2013: PloS One
Mooyad A Ahmed, K S Sureshkannan, Zaid R Raouf, Sreedharan V Koliyadan, Christopher S Grant, Ahmed H Al-Habsi, P A M Saparamadu, Dhuha Al-Sajee
Adrenal oncocytic neoplasms (AONs) are a rare group of tumours with a somewhat uncertain natural history and clinical behaviour. Out of 46 cases of AON reported to date, 6 cases were histologically classified as neoplasms with uncertain malignant potential. We report the case of a 35-year-old male with an incidentally-detected large AON with mostly benign morphology and some characteristics which would make its behaviour uncertain.
May 2013: Sultan Qaboos University Medical Journal
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