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Sara J Healy, Haikady N Nagaraja, Dhuha Alwan, Kathleen M Dungan
To determine prevalence, predictors, and outcomes of steroid-induced hyperglycemia in hospitalized patients with hematologic malignancies METHODS: We performed retrospective analysis of patients who were hospitalized on any of the four hematology services or bone marrow transplant service and who received systemic steroids during a 2-month period. Mean glucoses for days 1-4 and maximum glucose were calculated and the total daily steroid dose was converted to equivalent dose of dexamethasone. Hyperglycemia was defined as any glucose >9...
January 6, 2017: Endocrine
Eric Gluck, Dhuha Maki
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
Dhuha Tarik Nassar, Omran S Habib, Abbas Ali Mansour
AIM: To measure the incidence and determinants (predictors) of hypoglycemia among patients with type 2 diabetes mellitus (T2DM) who were on insulin treatment for at least one year. METHODS: The present study is an out-patients based inquiry about the risk and predictors of hypoglycemia among patients with T2DM seeking care at the Al-Faiha Specialized Diabetes, Endocrine, and Metabolism Center, in Basrah over a period of 7 mo (from 15(th) of April, 2013 to 15(th) of October, 2013)...
October 15, 2016: World Journal of Diabetes
Manhal Izzy, Kinesh Changela, Dhuha Alhankawi, Nami Safai Haeri, Sulay Shah, Ghalib Jibara, Sury Anand, Shashideep Singhal
BACKGROUND: The negative effect of diabetes mellitus (DM) on the colonoscopy preparation has been previously established. Metabolic syndrome has been shown to increase risk for malignancy and possibly for premalignant lesions. This study aimed to investigate the impact of DM control on colonoscopy outcomes including bowel preparation and adenoma detection rate (ADR). METHODS: We included patients with DM who underwent colonoscopy in our hospital and had a documented glycated hemoglobin (HbA1C) within 3 months...
July 2016: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
Donna M D'Souza, Sarah Zhou, Irena A Rebalka, Blair MacDonald, Jasmin Moradi, Matthew P Krause, Dhuha Al-Sajee, Zubin Punthakee, Mark A Tarnopolsky, Thomas J Hawke
Type 1 diabetes (T1D) negatively influences skeletal muscle health; however, its effect on muscle satellite cells (SCs) remains largely unknown. SCs from samples from rodents (Akita) and human subjects with T1D were examined to discern differences in SC density and functionality compared with samples from their respective control subjects. Examination of the Notch pathway was undertaken to investigate its role in changes to SC functionality. Compared with controls, Akita mice demonstrated increased muscle damage after eccentric exercise along with a decline in SC density and myogenic capacity...
October 2016: Diabetes
Salwan Yousif Hanna Bede, Waleed Khaleel Ismael, Dhuha Al-Assaf
Facial trauma in children and adolescents is reported to range from 1% to 30%. Because of many anatomical, physiological, and psychological characteristics of the pediatric population, maxillofacial injuries in children should be treated with special consideration that is attributable to certain features inherent in facial growth patterns of children. This study evaluated maxillofacial injuries in 726 children in terms of incidence, patterns of injury, causes, and treatment modalities and compared these parameters among 3 pediatric age groups...
May 2016: Journal of Craniofacial Surgery
Kinesh Changela, Dhuha Alhankawi, Sury Anand, Mahesh Krishnaiah
No abstract text is available yet for this article.
April 2016: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
Amani El-Gammal, John-Paul Oliveria, Karen Howie, Richard Watson, Patrick Mitchell, Ruchong Chen, Adrian Baatjes, Steven Smith, Dhuha Al-Sajee, Thomas J Hawke, Kieran J Killian, Gail M Gauvreau, Paul M O'Byrne
RATIONALE: Dendritic cells (DCs) are antigen-presenting cells essential for the initiation of T-cell responses. Allergen inhalation increases the number of airway DCs and the release of epithelial-derived cytokines, such as IL-33 and thymic stromal lymphopoietin (TSLP), that activate DCs. OBJECTIVES: To examine the effects of inhaled allergen on bone marrow production of DCs and their trafficking into the airways in subjects with allergic asthma, and to examine IL-33 and TSPL receptor expression on DCs...
July 15, 2016: American Journal of Respiratory and Critical Care Medicine
Donna M D'Souza, Karin E Trajcevski, Dhuha Al-Sajee, David C Wang, Melissa Thomas, Judy E Anderson, Thomas J Hawke
A healthy skeletal muscle mass is essential in attenuating the complications of obesity. Importantly, healthy muscle function is maintained through adequate repair following overuse and injury. The purpose of this study was to investigate the impact of diet-induced obesity (DIO) on skeletal muscle repair and the functionality of the muscle satellite cell (SC) population. Male C57BL/6J mice were fed a standard chow or high-fat diet (60% kcal fat; DIO) for 8 weeks. Muscles from DIO mice subjected to cardiotoxin injury displayed attenuated muscle regeneration, as indicated by prolonged necrosis, delayed expression of MyoD and Myogenin, elevated collagen content, and persistent embryonic myosin heavy chain expression...
August 2015: Physiological Reports
Daniel J O'Neill, Stuart Charles Williamson, Dhuha Alkharaif, Isabella Christina Mazzaro Monteiro, Marilyn Goudreault, Luke Gaughan, Craig N Robson, Anne-Claude Gingras, Olivier Binda
The lysine methyltransferase SETD6 modifies the histone variant H2AZ, a key component of nuclear receptor-dependent transcription. Herein, we report the identification of several factors that associate with SETD6 and are implicated in nuclear hormone receptor signaling. Specifically, SETD6 associates with the estrogen receptor α (ERα), histone deacetylase HDAC1, metastasis protein MTA2, and the transcriptional co-activator TRRAP. Luciferase reporter assays identify SETD6 as a transcriptional repressor, in agreement with its association with HDAC1 and MTA2...
July 2014: Epigenetics: Official Journal of the DNA Methylation Society
Donna M D'Souza, Dhuha Al-Sajee, Thomas J Hawke
Diabetes mellitus is defined as a group of metabolic diseases that are associated with the presence of a hyperglycemic state due to impairments in insulin release and/or function. While the development of each form of diabetes (Type 1 or Type 2) drastically differs, resultant pathologies often overlap. In each diabetic condition, a failure to maintain healthy muscle is often observed, and is termed diabetic myopathy. This significant, but often overlooked, complication is believed to contribute to the progression of additional diabetic complications due to the vital importance of skeletal muscle for our physical and metabolic well-being...
2013: Frontiers in Physiology
Mats I Nilsson, Aliyah A Nissar, Dhuha Al-Sajee, Mark A Tarnopolsky, Gianni Parise, Boleslav Lach, Dieter O Fürst, Peter F M van der Ven, Rudolf A Kley, Thomas J Hawke
Xin is a striated muscle-specific protein that is localized to the myotendinous junction in skeletal muscle. However, in injured mouse muscle, Xin expression is up-regulated and observed throughout skeletal muscle fibers and within satellite cells. In this study, Xin was analyzed by immunofluorescent staining in skeletal muscle samples from 47 subjects with various forms of myopathy, including muscular dystrophies, inflammatory myopathies, mitochondrial/metabolic myopathy, and endocrine myopathy. Results indicate that Xin immunoreactivity is positively and significantly correlated (rs = 0...
December 2013: American Journal of Pathology
Karin E Trajcevski, Hayley M O'Neill, David C Wang, Melissa M Thomas, Dhuha Al-Sajee, Gregory R Steinberg, Rolando B Ceddia, Thomas J Hawke
BACKGROUND: Diet-induced obesity is a rising health concern which can lead to the development of glucose intolerance and muscle insulin resistance and, ultimately, type II diabetes mellitus. This research investigates the associations between glucose intolerance or muscle insulin resistance and tissue specific changes during the progression of diet-induced obesity. METHODOLOGY: C57BL/6J mice were fed a normal or high-fat diet (HFD; 60% kcal fat) for 3 or 8 weeks...
2013: PloS One
Matthew P Krause, Dhuha Al-Sajee, Donna M D'Souza, Irena A Rebalka, Jasmin Moradi, Michael C Riddell, Thomas J Hawke
BACKGROUND: Systemic elevations in PAI-1 suppress the fibrinolytic pathway leading to poor collagen remodelling and delayed regeneration of tibialis anterior (TA) muscles in type-1 diabetic Akita mice. However, how impaired collagen remodelling was specifically attenuating regeneration in Akita mice remained unknown. Furthermore, given intrinsic differences between muscle groups, it was unclear if the reparative responses between muscle groups were different. PRINCIPAL FINDINGS: Here we reveal that diabetic Akita muscles display differential regenerative responses with the TA and gastrocnemius muscles exhibiting reduced regenerating myofiber area compared to wild-type mice, while soleus muscles displayed no difference between animal groups following injury...
2013: PloS One
Mooyad A Ahmed, K S Sureshkannan, Zaid R Raouf, Sreedharan V Koliyadan, Christopher S Grant, Ahmed H Al-Habsi, P A M Saparamadu, Dhuha Al-Sajee
Adrenal oncocytic neoplasms (AONs) are a rare group of tumours with a somewhat uncertain natural history and clinical behaviour. Out of 46 cases of AON reported to date, 6 cases were histologically classified as neoplasms with uncertain malignant potential. We report the case of a 35-year-old male with an incidentally-detected large AON with mostly benign morphology and some characteristics which would make its behaviour uncertain.
May 2013: Sultan Qaboos University Medical Journal
Kelly Coffey, Lynsey Rogerson, Claudia Ryan-Munden, Dhuha Alkharaif, Jacqueline Stockley, Rakesh Heer, Kanagasabai Sahadevan, Daniel O'Neill, Dominic Jones, Steven Darby, Peter Staller, Alejandra Mantilla, Luke Gaughan, Craig N Robson
The androgen receptor (AR) is a key molecule involved in prostate cancer (PC) development and progression. Post-translational modification of the AR by co-regulator proteins can modulate its transcriptional activity. To identify which demethylases might be involved in AR regulation, an siRNA screen was performed to reveal that the demethylase, KDM4B, may be an important co-regulator protein. KDM4B enzymatic activity is required to enhance AR transcriptional activity; however, independently of this activity, KDM4B can enhance AR protein stability via inhibition of AR ubiquitination...
April 2013: Nucleic Acids Research
Dhuha Al-Sajee, Jan D Huizinga
Interstitial cells of cajal (ICC) are specialised cells located within the musculature of the gastrointestinal tract (GIT). Although they form only 5% of the cells in the musculature of the GIT, they play a critical role in regulating smooth muscle function and GIT motility in coordination with the enteric nervous system. C-kit is a transmembrane glycoprotein that plays a critical role in ICC development and maturation. Physiological conditions such as ageing, as well as pathological conditions that have different disease processes, negatively affect ICC networks and function...
November 2012: Sultan Qaboos University Medical Journal
Salwan Yousif Hanna Bede, Waleed Khaleel Ismael, Dhuha A Al-Assaf, Saad Salem Omer
The study evaluates the incidence of inferior alveolar nerve injuries in mandibular fractures, the duration of their recovery, and the factors associated with them. Fifty-two patients with mandibular fractures involving the ramus, angle, and body regions were included in this study; the inferior alveolar nerve was examined for neurological deficit posttraumatically using sharp/blunt differentiation method, and during the follow-up period the progression of neural recovery was assessed. The incidence of neural injury of the inferior alveolar nerve was 42...
November 2012: Journal of Craniofacial Surgery
Farah Mustafa, Dhuha Al Amri, Farah Al Ali, Noor Al Sari, Sarah Al Suwaidi, Preethi Jayanth, Pretty S Philips, Tahir A Rizvi
BACKGROUND: This study mapped regions of genomic RNA (gRNA) important for packaging and propagation of mouse mammary tumor virus (MMTV). MMTV is a type B betaretrovirus which preassembles intracellularly, a phenomenon distinct from retroviruses that assemble the progeny virion at cell surface just before budding such as the type C human and feline immunodeficiency viruses (HIV and FIV). Studies of FIV and Mason-Pfizer monkey virus (MPMV), a type D betaretrovirus with similar intracellular virion assembly processes as MMTV, have shown that the 5' untranslated region (5' UTR) and 5' end of gag constitute important packaging determinants for gRNA...
2012: PloS One
Qutaiba Amir Tawfic, Rajini Kausalya, Dhuha Al-Sajee, Jyoti Burad, Ahmed K Mohammed, Aravind Narayanan
OBJECTIVES: Sickle cell disease (SCD) is an inherited disease caused by an abnormal type of haemoglobin. It is one of the most common genetic blood disorders in the Gulf area, including Oman. It may be associated with complications requiring intensive care unit (ICU) admission. This study investigated the causes of ICU admission for SCD patients. METHODS: This was a retrospective analysis of all adult patients ≥12 years old with SCD admitted to Sultan Qaboos University Hospital (SQUH) ICU between 1st January 2005 and 31st December 2009...
May 2012: Sultan Qaboos University Medical Journal
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