keyword
https://read.qxmd.com/read/38536760/nonpharmacologic-rate-control-of-postoperative-atrial-fibrillation-in-the-canine-sterile-pericarditis-model
#1
JOURNAL ARTICLE
Seungyup Lee, Don Wallick, Celeen Khrestian, Dragan Juzbasich, Daniel Laurita, Gregory Rushing, Jayakumar Sahadevan
INTRODUCTION: Postoperative atrial fibrillation (POAF) is common following open heart surgery, and is associated with significant morbidity. Medications used for ventricular rate control of POAF may not be effective in controlling rapid ventricular rates during the postoperative period because of increased sympathetic tone. The purpose of this study was to develop nonpharmacologic rate control of POAF by atrioventricular node (AVN) fat pad stimulation using clinically available temporary pacing wires in the canine sterile pericarditis model...
March 27, 2024: Journal of Cardiovascular Electrophysiology
https://read.qxmd.com/read/38536028/insights-on-obstetric-outcomes-in-pregnant-individuals-with-marfan-syndrome-evidence-from-the-national-inpatient-sample
#2
JOURNAL ARTICLE
Saeed Baradwan, Majed S Alshahrani, Khalid Khadawardi, Maha Tulbah, Osama Alomar, Abdullah Alyousef, Ibtihal A Bukhari, Ahmed Abu-Zaid
BACKGROUND: We investigated the potential association between Marfan Syndrome (MFS) and adverse obstetric outcomes using the National Inpatient Sample (NIS) database. METHODS: We utilized the International Classification of Diseases (ICD-10) system to identify relevant codes and extracted data from the NIS database covering the period 2016-2019. Descriptive statistics and χ2 tests were employed to summarize and compare baseline characteristics. Univariate and multivariate regression analyses (adjusted for age, race, hospital region, smoking status, and alcohol misuse) were conducted to evaluate association between MFS and adverse obstetric outcomes...
March 27, 2024: Minerva obstetrics and gynecology
https://read.qxmd.com/read/38535807/inhibition-of-aflatoxin-production-in-aspergillus-flavus-by-a-klebsiella-sp-and-its-metabolite-cyclo-l-ala-gly
#3
JOURNAL ARTICLE
Shohei Sakuda, Masaki Sunaoka, Maho Terada, Ayaka Sakoda, Natsumi Ishijima, Noriko Hakoshima, Kenichi Uchida, Hirofumi Enomoto, Tomohiro Furukawa
During an experiment where we were cultivating aflatoxigenic Aspergillus flavus on peanuts, we accidentally discovered that a bacterium adhering to the peanut strongly inhibited aflatoxin (AF) production by A. flavus . The bacterium, isolated and identified as Klebsiella aerogenes , was found to produce an AF production inhibitor. Cyclo(l-Ala-Gly), isolated from the bacterial culture supernatant, was the main active component. The aflatoxin production-inhibitory activity of cyclo(l-Ala-Gly) has not been reported...
March 8, 2024: Toxins
https://read.qxmd.com/read/38535264/bonding-pretreatment-of-aesthetic-dental-cad-cam-materials-through-surface-etching-with-a-mixed-aqueous-solution-of-ammonium-fluoride-and-ammonium-hydrogen-sulfate
#4
JOURNAL ARTICLE
Yusaku Nishizawa, Tatsuo Kawamoto, Hiroshi Ikeda
Hydrofluoric acid (HF) is commonly used as an etchant for the pretreatment of dental computer-aided design/computer-aided manufacturing (CAD-CAM) materials, such as glass-ceramics and resin composites. Despite its effectiveness, the harmful and hazardous nature of HF has raised significant safety concerns. In contrast, ammonium fluoride (AF) is known for its relatively low toxicity but has limited etching capability. This study explored the potential of ammonium hydrogen sulfate (AHS), a low-toxicity and weak acid, to enhance the etching ability of aqueous AF solutions for the bonding pretreatment of CAD-CAM materials...
March 14, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38535174/the-effect-of-geoclimatic-factors-on-the-distribution-of-paracoccidioidomycosis-in-mato-grosso-do-sul-brazil
#5
JOURNAL ARTICLE
Larissa Rodrigues Fabris, Nathan Guilherme de Oliveira, Bruna Eduarda Bortolomai, Lavínia Cássia Ferreira Batista, Marcos Henrique Sobral, Alisson André Ribeiro, Ursulla Vilella Andrade, Antonio Conceição Paranhos Filho, Lídia Raquel de Carvalho, Ida Maria Foschiani Dias Baptista, Rinaldo Poncio Mendes, Anamaria Mello Miranda Paniago
The incidence of paracoccidioidomycosis (PCM) varies in Latin America, and it is influenced by environmental factors. This study evaluated the distribution of PCM acute/subacute form (AF) cases and their correlation with geoclimatic factors in the Mato Grosso do Sul (MS) state. The study included 81 patients diagnosed with the PCM/AF at the University Hospital of the Federal University of Mato Grosso do Sul between January 1980 and February 2022. Geographic coordinates, health microregion of patient's residence, compensated average temperature, relative air humidity (RH), El Niño Southern Oscillation (ENSO), and average global temperature were analyzed...
February 21, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535110/left-ventricular-diastolic-dysfunction-is-associated-with-poor-functional-outcomes-after-endovascular-thrombectomy
#6
JOURNAL ARTICLE
Tony Y W Li, Emma M S Toh, Ying Ying Koh, Aloysius S T Leow, Bernard P L Chan, Hock-Luen Teoh, Raymond C S Seet, Anil Gopinathan, Cunli Yang, Vijay K Sharma, Leonard L L Yeo, Mark Y Chan, William K F Kong, Kian-Keong Poh, Benjamin Y Q Tan, Ching-Hui Sia
INTRODUCTION: With the advent of endovascular thrombectomy (ET), patients with acute ischaemic strokes (AIS) with large vessel occlusion (LVO) have seen vast improvements in treatment outcomes. Left ventricular diastolic dysfunction (LVDD) has been shown to herald poorer prognosis in conditions such as myocardial infarction. However, whether LVDD is related to functional recovery and outcomes in ischaemic stroke remains unclear. We studied LVDD for possible relation with clinical outcomes in patients with LVO AIS who underwent ET...
March 5, 2024: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/38535093/cardiopulmonary-exercise-testing-in-heart-failure
#7
REVIEW
Michel Juarez, Cristian Castillo-Rodriguez, Dina Soliman, Gaspar Del Rio-Pertuz, Kenneth Nugent
Cardiopulmonary exercise testing (CPET) provides important information for the assessment and management of patients with heart failure. This testing measures the respiratory and cardiac responses to exercise and allows measurement of the oxygen uptake (V˙O2 ) max and the relationship between minute ventilation (V˙E) and carbon dioxide excretion (V˙CO2 ). These two parameters help classify patients into categories that help predict prognosis, and patients with a V˙O2 < 14 mL/kg/min and V˙E/V˙CO2 slope >35 have a poor prognosis...
February 20, 2024: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/38535079/skin-lesions-with-loss-of-tissue-and-cutaneous-onset-sepsis-the-skin-infection-sepsis-relationship
#8
JOURNAL ARTICLE
Adriana-Ionela Pătrașcu, Dan Vâță, Doinița Temelie-Olinici, Mădălina Mocanu, Dumitrița-Lenuța Guguluș, Mădălina Marinescu, Liviu Stafie, Bogdan-Marian Tarcău, Ioana Creţu, Ioana-Adriana Popescu, Carmen-Diana Cimpoeșu, Laura Gheucă-Solovăstru
Infectious and inflammatory dermatoses featuring skin lesions with loss of tissue expose skin layers to microbial invasions, disrupt the normal skin microbiome, and potentially lead to sepsis. However, literature data on the incidence of cutaneous-onset sepsis are scarce. This retrospective observational study assessed hospital admissions for primary skin lesions without bacterial infections and sepsis during 2020-2022 in the largest emergency hospital in NE Romania. Of 509 patients, 441 had infected lesions, 78 had sepsis caused by venous ulcers from microbial eczema cellulitis, superinfected bullous dermatoses, erysipelas, and erythroderma...
March 21, 2024: Diagnostics
https://read.qxmd.com/read/38534886/drug-drug-interactions-of-fxi-inhibitors-clinical-relevance
#9
REVIEW
Nicola Ferri, Elisa Colombo, Alberto Corsini
Inhibitors of the factor FXI represent a new class of anticoagulant agents that are facing clinical approval for the treatment of acute coronary syndrome (ACS), venous thromboembolism (VTE), and stroke prevention of atrial fibrillation (AF). These new inhibitors include chemical small molecules (asundexian and milvexian), monoclonal antibodies (abelacimab, osocimab, and xisomab), and antisense oligonucleotides (IONIS-FXIRX and fesomersen), and thus, they have very peculiar and different pharmacokinetic and pharmacodynamic properties...
March 21, 2024: Hematology Reports
https://read.qxmd.com/read/38534523/profile-of-a-multivariate-observation-under-destructive-sampling-a-monte-carlo-approach-to-a-case-of-spina-bifida
#10
JOURNAL ARTICLE
Tianyuan Guan, Rigwed Tatu, Koffi Wima, Marc Oria, Jose L Peiro, Chia-Ying Lin, Marepalli B Rao
A biodegradable hybrid polymer patch was invented at the University of Cincinnati to cover gaps on the skin over the spinal column of a growing fetus, characterized by the medical condition spina bifida. The inserted patch faces amniotic fluid (AF) on one side and cerebrospinal fluid on the other side. The goal is to provide a profile of the roughness of a patch over time at 0, 4, 8, 12, and 16 weeks with a 95% confidence band. The patch is soaked in a test tube filled with either amniotic fluid (AF) or phosphate-buffered saline (PBS) in the lab...
March 3, 2024: Bioengineering
https://read.qxmd.com/read/38534473/a-comparison-of-the-impact-of-pharmacological-treatments-on-cardioversion-rate-control-and-mortality-in-data-driven-atrial-fibrillation-phenotypes-in-critical-care
#11
JOURNAL ARTICLE
Alexander Lacki, Antonio Martinez-Millana
Critical care physicians are commonly faced with patients exhibiting atrial fibrillation (AF), a cardiac arrhythmia with multifaceted origins. Recent investigations shed light on the heterogeneity among AF patients by uncovering unique AF phenotypes, characterized by differing treatment strategies and clinical outcomes. In this retrospective study encompassing 9401 AF patients in an intensive care cohort, we sought to identify differences in average treatment effects (ATEs) across different patient groups. We extract data from the MIMIC-III database, use hierarchical agglomerative clustering to identify patients' phenotypes, and assign them to treatment groups based on their initial drug administration during AF episodes...
February 20, 2024: Bioengineering
https://read.qxmd.com/read/38534327/isolevuglandins-promote-mitochondrial-dysfunction-and-electrophysiologic-abnormalities-in-atrial-cardiomyocytes
#12
JOURNAL ARTICLE
Tuerdi Subati, Zhenjiang Yang, Matthew B Murphy, Joshua M Stark, David Z Trykall, Sean S Davies, Joey V Barnett, Katherine T Murray
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, yet the cellular and molecular mechanisms underlying the AF substrate remain unclear. Isolevuglandins (IsoLGs) are highly reactive lipid dicarbonyl products that mediate oxidative stress-related injury. In murine hypertension, the lipid dicarbonyl scavenger 2-hydroxybenzylamine (2-HOBA) reduced IsoLGs and AF susceptibility. We hypothesized that IsoLGs mediate detrimental pathophysiologic effects in atrial cardiomyocytes that promote the AF substrate...
March 9, 2024: Cells
https://read.qxmd.com/read/38534143/triazole-resistance-in-aspergillus-fumigatu-s-isolated-from-a-tomato-production-environment-exposed-to-propiconazole
#13
JOURNAL ARTICLE
Alejandra M Jimenez Madrid, Raees A Paul, Francesca Rotondo, Loic Deblais, Gireesh Rajashekara, Sally A Miller, Melanie L Lewis Ivey
UNLABELLED: The emergence of azole-resistant Aspergillus fumigatus (AR Af ) across the world is an important public health concern. We sought to determine if propiconazole, a demethylase inhibitor (DMI) fungicide, exerted a selective pressure for AR Af in a tomato production environment following multiple exposures to the fungicide. A tomato field trial was established in 2019 and propiconazole was applied weekly until harvest. Soil, leaf, and fruit (when present) samples were collected at baseline and after each propiconazole application...
March 27, 2024: Applied and Environmental Microbiology
https://read.qxmd.com/read/38534024/letter-to-the-editor-from-sukor-and-kamaruddin-higher-risk-of-incident-hyperthyroidism-in-patients-with-atrial-fibrillation
#14
JOURNAL ARTICLE
Norlela Sukor, Nor Azmi Kamaruddin
No abstract text is available yet for this article.
March 27, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38533983/risk-of-death-and-cardiovascular-events-in-asian-patients-with-atrial-fibrillation-and-chronic-obstructive-pulmonary-disease-a-report-from-the-prospective-aphrs-registry
#15
JOURNAL ARTICLE
Tommaso Bucci, Giulio Francesco Romiti, Alena Shantsila, Wee-Siong Teo, Hyung-Wook Park, Wataru Shimizu, Bernadette Corica, Marco Proietti, Hung-Fat Tse, Tze-Fan Chao, Frederick Frost, Gregory Y H Lip
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is associated with an increased risk of adverse events in patients with atrial fibrillation (AF); however, few data are available on this topic in Asian populations. METHODS AND RESULTS: Prospective observational study conducted on patients with AF enrolled in the Asia-Pacific Heart Rhythm Society (APHRS) AF Registry. The diagnosis of COPD was based on data reported in the case report form by the investigators...
March 27, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38533970/cardiomyopathy-in-patients-with-acute-ischemic-stroke-and-methamphetamine-use-relevance-for-cardioembolic-stroke-and-outcome
#16
JOURNAL ARTICLE
Sook Joung Lee, Shimeng Liu, Haley Blackwill, Dana Stradling, Mohammad Shafie, Wengui Yu
BACKGROUND: Methamphetamine use has emerged as a major risk factor for cardiovascular and cerebrovascular disease in young adults. The aim of this study was to investigate a possible association of methamphetamine use with cardioembolic stroke. METHODS AND RESULTS: We performed a retrospective study of patients with acute ischemic stroke admitted at our medical center between 2019 and 2022. All patients were screened for methamphetamine use and cardiomyopathy, defined as left ventricular ejection fraction ≤45%...
March 27, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38533963/left-atrial-cardiomyopathy-a-puzzling-disease-process-short-of-an-easy-answer
#17
EDITORIAL
Adrian M Petzl, Rajat Deo
No abstract text is available yet for this article.
March 27, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38533962/lower-recurrence-rates-of-atrial-fibrillation-and-mace-events-after-early-compared-to-late-ablation-a-danish-nationwide-register-study
#18
JOURNAL ARTICLE
Jacob Tønnesen, Martin H Ruwald, Jannik Pallisgaard, Peter Vibe Rasmussen, Arne Johannessen, Jim Hansen, Rene H Worck, Christopher R Zörner, Lise Riis-Vestergaard, Charlotte Middelfart, Samuel K Sørensen, Stefan Sattler, Gunnar Gislason, Morten Lock Hansen
BACKGROUND: Guidelines recommend prioritizing treatment with antiarrhythmic drugs before referral of patients with atrial fibrillation to ablation, delaying a potential subsequent ablation. However, delaying ablation may affect ablation outcomes. We sought to investigate the impact of duration from diagnosis to ablation on the risk of atrial fibrillation recurrence and adverse events. METHODS AND RESULTS: Using Danish nationwide registries, all patients with first-time ablation for atrial fibrillation were identified and included from 2010 to 2018...
March 27, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38533961/correlates-of-plasma-nt-probnp-cyclic-gmp-ratio-in-heart-failure-with-preserved-ejection-fraction-an-analysis-of-the-relax-trial
#19
JOURNAL ARTICLE
Leonard Chiu, Vineet Agrawal, David Armstrong, Evan Brittain, Sheila Collins, Anna R Hemnes, Joseph A Hill, JoAnn Lindenfeld, Sanjiv J Shah, Lynne W Stevenson, Thomas J Wang, Deepak K Gupta
BACKGROUND: Phosphodiesterases degrade cyclic GMP (cGMP), the second messenger that mediates the cardioprotective effects of natriuretic peptides. High natriuretic peptide/cGMP ratio may reflect, in part, phosphodiesterase activity. Correlates of natriuretic peptide/cGMP in patients with heart failure with preserved ejection fraction are not well understood. Among patients with heart failure with preserved ejection fraction in the RELAX (Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Heart Failure With Preserved Ejection Fraction) trial, we examined (1) cross-sectional correlates of circulating NT-proBNP (N-terminal pro-B-type natriuretic peptide)/cGMP ratio, (2) whether selective phosphodiesterase-5 inhibition by sildenafil changed the ratio, and (3) whether the effect of sildenafil on 24-week outcomes varied by baseline ratio...
March 27, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38533958/associations-of-alcohol-consumption-with-left-atrial-morphology-and-function-in-a-population-at-high-cardiovascular-risk
#20
JOURNAL ARTICLE
Aniqa B Alam, Estefania Toledo-Atucha, Dora Romaguera, Angel M Alonso-Gómez, Miguel A Martínez-Gonzalez, Lucas Tojal-Sierra, Marta Noris Mora, Caterina Mas-Llado, Linzi Li, Ines Gonzalez-Casanova, Jordi Salas-Salvadó, Montserrat Fitó, Alvaro Alonso
BACKGROUND: Excessive alcohol consumption has been associated with increased risk of atrial fibrillation, although the underlying mechanisms remain unclear. An enlarged left atrium and impaired left atrial function may lead to atrial fibrillation. The association of alcohol consumption with structural and functional left atrial measures, however, has received limited attention. METHODS AND RESULTS: We studied 503 participants from the PREDIMED-Plus (Prevención con Dieta Mediterránea) trial, a randomized trial testing intensive weight loss intervention with an energy-reduced Mediterranean diet and physical activity promotion in preventing cardiovascular disease in adults with metabolic syndrome...
March 27, 2024: Journal of the American Heart Association
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