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Mirabeau Saha, Caroline H Roney, Jason D Bayer, Marianna Meo, Hubert Cochet, Remi Dubois, Edward J Vigmond
The mechanisms underlying atrial fibrillation (AF), the most common sustained cardiac rhythm disturbance, remain elusive. Atrial fibrosis plays an important role in the development of AF and rotor dynamics. Both electrical wavelength (WL) and the degree of atrial fibrosis change as AF progresses. However, their combined effect on rotor core location remains unknown. The aim of this study was to analyze the effects of WL change on rotor core location in both fibrotic and non-fibrotic atria. Three patient specific fibrosis distributions (total fibrosis content: 16...
2018: Frontiers in Physiology
Xiaoya Zhou, Zhuo Wang, Bing Huang, Shenxu Yuan, Xia Sheng, Lilei Yu, Guannan Meng, Yuhong Wang, Sunny S Po, Hong Jiang
Background: The NRG1/ErbB4 signaling mechanism has been widely studied in the central nervous system for many years. However, the role of this pathway in modulating the intrinsic cardiac nervous system is largely unknown. Objective: The present study investigated whether the NRG1/ErbB4 signaling system affects the activity of major atrial ganglionated plexi (GP) in a paroxysmal atrial fibrillation (AF) model by 6-h rapid atrial pacing (RAP). Methods: Twenty-four dogs were randomly divided into (1) a control group (saline microinjections into GP), (2) RAP group (saline microinjections into GP plus 6 h-RAP), (3) NRG1 group (microinjections of neuregulin-1 into GP plus 6 h-RAP) and (4) NRG1 + ERA group (microinjections of neuregulin-1 and ErbB4 receptor antagonist-ERA into GP plus 6 h-RAP)...
2018: Frontiers in Physiology
Katharina Schoene, Arash Arya, Cosima Jahnke, Ingo Paetsch, Nikolaos Dagres, Andreas Bollmann, Gerhard Hindricks, Philipp Sommer
BACKGROUND: Thermal injury during radiofrequency ablation (RFA) of atrial fibrillation (AF) can lead to pulmonary vein stenosis (PVS). It is currently unclear if routine screening for PVS by imaging (ECHO, CT) is clinically meaningful and if there is a correlation between PVS and the electroanatomical mapping system (EAMS) used for the ablation procedure. It was therefore investigated in the current single center experience. METHODS: All patients from January 2004 to December 2016 with the diagnosis of PVS after interventional ablation of AF by radiofrequency were retrospectively analyzed...
September 24, 2018: Cardiology Journal
Xiaojun Wang, Qian Fu, Fujian Song, Wenzhen Li, Xiaoxv Yin, Wei Yue, Feng Yan, Hong Zhang, Hao Zhang, Zhenjie Teng, Longde Wang, Yanhong Gong, Zhihong Wang, Zuxun Lu
Data presented in this article are supplementary material to our research article entitled " Prevalence of Atrial Fibrillation in Different Socioeconomic Regions of China and Its Association with Stroke: Results from a National Stroke Screening Survey" (Wang et al., 2018) [1]. This data article summarizes previous studies of Atrial Fibrillation (AF) prevalence in China, and estimates the association between AF and stroke in different socioeconomic regions of China through a national survey.
August 2018: Data in Brief
Michael A Colman, Priyanka Saxena, Sarah Kettlewell, Antony J Workman
Introduction: The development of improved diagnosis, management, and treatment strategies for human atrial fibrillation (AF) is a significant and important challenge in order to improve quality of life for millions and reduce the substantial social-economic costs of the condition. As a complex condition demonstrating high variability and relation to other cardiac conditions, the study of AF requires approaches from multiple disciplines including single-cell experimental electrophysiology and computational modeling...
2018: Frontiers in Physiology
Courtney Weber, Joseph Hung, Siobhan Hickling, Ian Li, Brendan McQuillan, Tom Briffa
OBJECTIVE: To determine if increasing hospitalisations for non-valvular atrial fibrillation (NVAF) in Western Australia (WA) was due to incident (first-ever) or repeat hospitalisations, an ageing population structure, changing procedural practice or a combination of these factors. METHODS: We conducted a longitudinal retrospective population study on all WA residents aged 25-94 years between 2000 and 2013, with a principal hospital discharge diagnosis of NVAF...
September 13, 2018: International Journal of Cardiology
Tomas Konecny, Peter A Brady, Jae Y Park, Pavan K Reddy, Lukas Ruzek, Lukas Mach, Sean M Caples, Virend K Somers
In patients without atrial fibrillation and flutter (AF), obstructive sleep apnea (OSA) is associated with cyclic and often marked changes in heart rate (HR). We aimed to assess whether presence of OSA impacts optimal HR control in patients in AF. We retrospectively correlated diurnal HR patterns (recorded by 24-hour Holter monitoring) in patients with AF who independently also underwent diagnostic polysomnography. Exclusion criteria were paced rhythm or inadequate recordings from polysomnography and Holter monitoring...
August 4, 2018: American Journal of Cardiology
Minetaka Maeda, Kageyuki Oba, Satoshi Yamaguchi, Osamu Arasaki, Masataka Sata, Hiroaki Masuzaki, Michio Shimabukuro
Although increasing evidence suggests that epicardial adipose tissue volume (EATV) is associated with post-ablation atrial fibrillation (AF), ranges of EATV predictive of post-ablation recurrence of AF remain unclear. In this study, we evaluated: (1) relationships between EATV and characteristics of AF, (2) impact of EATV on recurrent AF after radiofrequency ablation; , and (3) cut-off point for recurrent AF using a receiver operating characteristic curve. In 218 consecutive symptomatic patients undergoing who underwent ablation for AF (143 paroxysmal AF; 78 persistent AF), the EATV index (EATVI: EATV/body surface area, mL/m2 ) was measured using 320-row multidetector computed tomography...
August 21, 2018: American Journal of Cardiology
Sebastian Bohnen, Maxim Avanesov, Annika Jagodzinski, Renate B Schnabel, Tanja Zeller, Mahir Karakas, Jan Schneider, Enver Tahir, Ersin Cavus, Clemens Spink, Ulf K Radunski, Francisco Ojeda, Gerhard Adam, Stefan Blankenberg, Gunnar K Lund, Kai Muellerleile
BACKGROUND: The purpose of this work is to describe the objectives and design of cardiovascular magnetic resonance (CMR) imaging in the single center, prospective, population-based Hamburg City Health study (HCHS). The HCHS aims at improving risk stratification for coronary artery disease (CAD), atrial fibrillation (AF) and heart failure (HF). METHODS: The HCHS will finally include 45,000 inhabitants of the city of Hamburg (Germany) between 45 and 74 years who undergo an extensive cardiovascular evaluation and collection of biomaterials...
September 24, 2018: Journal of Cardiovascular Magnetic Resonance
Jen-Hung Huang, Yung-Kuo Lin, Cheng-Chih Chung, Ming-Hsiung Hsieh, Wan-Chun Chiu, Yi-Jen Chen
Rivaroxaban, a direct factor Xa inhibitor, is widely used to reduce the chance of stroke in patients with atrial fibrillation (AF). It is not clear why the prothrombin time (PT) of the international normalized ratio (INR) fails to correlate with treatment using rivaroxaban in patients with AF. In this study, patient characteristics, the rivaroxaban dosage, AF type, drug history, biochemical properties, and hematological profiles were assessed in patients treated with rivaroxaban. In 69 patients with AF receiving rivaroxaban, 27 (39...
September 24, 2018: Clinical and Applied Thrombosis/hemostasis
Tetyana Kendzerska, Andrea Gershon, Clare Atzema, Paul Dorian, Iqwal Mangat, Gillian Hawker, Richard Leung
OBJECTIVES: We examined the relationship between newly diagnosed obstructive sleep apnea (OSA) and incident hospitalized atrial fibrillation (AF) over the subsequent ten years in a large arrhythmia-free cohort. METHODS: Adults referred between 1994 and 2010 to a large academic hospital with suspected OSA who were arrhythmia-free at the time of first diagnostic sleep study were included. Clinical data were linked to provincial health administrative data to define outcome...
September 19, 2018: Chest
Wei-Syun Hu, Cheng-Li Lin
OBJECTIVE: This investigation aimed at assessing the issue of incident atrial fibrillation (AF) associated with acute critical illness. METHODS: The study came from Taiwan and used that nation's Longitudinal Health Insurance Database 2000. Using propensity score matching, multivariable adjustment and competing risk methods, the correlations between the new-onset AF and critical illness (septicemia/septic shock, acute myocardial infarction【AMI】, hemorrhagic stroke and ischemic stroke) were investigated...
September 19, 2018: European Journal of Internal Medicine
Sang Hun Lee, Keun-Sik Hong, Ji Sung Lee, Yong-Jae Kim, Tae-Jin Song, Young Dae Kim, Man-Seok Park, Eung-Gyu Kim, Jae-Kwan Cha, Sang Min Sung, Byung-Woo Yoon, Oh Young Bang, Woo-Keun Seo, Yang-Ha Hwang, Seong Hwan Ahn, Dong-Wha Kang, Hyun Goo Kang, Kyung-Ho Yu, Sun U Kwon
OBJECTIVES: To investigate the predictors of hemorrhagic transformation (HT) in patients with mild atrial fibrillation-related stroke who were treated with early anticoagulation. We conducted a post-hoc subgroup analysis from Acute Cerebral Infarction Patients with Non-valvular Atrial Fibrillation (Triple AXEL) study. PATIENTS AND METHODS: The Triple AXEL study was a randomized, multicenter, open-label, blinded end-point evaluation, comparative phase 2 trial. To identify the relationship between the type of HT and risk factors...
September 9, 2018: Clinical Neurology and Neurosurgery
Larissa T Franco, Tânia Petta, George E Rottinghaus, Keliani Bordin, Gilmar A Gomes, Carlos A F Oliveira
A limited survey was conducted to assess the co-occurrence of aflatoxins (AF) B1 , B2 , G1 , and G2 ; fumonisins (FB) B1 and B2 ; ochratoxin A (OTA); zearalenone (ZEN); and deoxynivalenol (DON) in maize food (N = 26) and animal feed (N = 45) collected from 21 small-scale farms from the states of São Paulo (SP) and Santa Catarina (SC), Brazil. Samples evaluated were maize meal and maize flour for human consumption available in the farm households, and maize-based feed intended for broiler chicks, laying hens, and dairy cows...
September 21, 2018: Mycotoxin Research
Caijie Shen, Bin Kong, Yu Liu, Liang Xiong, Wei Shuai, Guangji Wang, Dajun Quan, He Huang
Recent years, the role of long non-coding RNAs (lncRNAs) in atrial fibrillation (AF) has been gradually elucidated. In the current study, we measured the expression of ten AF-related lncRNAs to do qRT-PCR analysis. LncRNA KCNQ1 overlapping transcript 1 (KCNQ1OT1) was found to be significantly upregulated in AF model and Ang-II-induced mice heart. CACNA1C has been reported as a biomarker in atrial fibrillation. Here, we found that the expression pattern of CACNA1C was consistent with that of KCNQ1OT1. Electrophysiological study was conducted to demonstrate the effect of KCNQ1OT1 and CACNA1C on the Effective refractory period (ERP), interatrial conduction time (IACT), incidence of AF and AF duration of Ang-II-induced mice heart...
September 18, 2018: Biochemical and Biophysical Research Communications
Danilo Cimadomo, Laura Rienzi, Valeria Romanelli, Erminia Alviggi, Paolo Emanuele Levi-Setti, Elena Albani, Ludovica Dusi, Letizia Papini, Claudia Livi, Francesca Benini, Antonella Smeraldi, Cristina Patassini, Filippo Maria Ubaldi, Antonio Capalbo
STUDY QUESTION: Can a second round of biopsy, vitrification and chromosomal testing provide a valid diagnosis where the first attempt fails? SUMMARY ANSWER: The risk of inconclusive chromosomal-assessment after trophectoderm biopsy was 2.5% but a further biopsy and vitrification-warming appeared not to impair the competence of euploid blastocysts. WHAT IS KNOWN ALREADY: The increasing implementation of multicell trophectoderm biopsy has significantly reduced the risk of inconclusive diagnosis after preimplantation-genetic-testing (PGT)...
September 18, 2018: Human Reproduction
Dolkun Rahmutula, Hao Zhang, Emily E Wilson, Jeffrey E Olgin
Aims: TGF-ß1 plays an important role in atrial fibrosis and atrial fibrillation (AF); previous studies have shown that the atria are more susceptible to TGF-ß1 mediated fibrosis than the ventricles. Natriuretic peptides play an important role in cardiac remodeling and fibrosis, but the role of natriuretic peptide clearance receptor (NPR-C) is largely unknown. We investigated the role of NPR-C in modulating TGF-ß1 signaling in the atria. Methods and results: MHC-TGF-ß1 transgenic mice (TGF-ß1-Tx), which develop isolated atrial fibrosis and AF, were cross-bred with NPR-C knock-out mice (NPR-C-KO)...
September 18, 2018: Cardiovascular Research
Bin Wang, Yusheng Xue, Fujun Shang, Sifeng Ni, Xiongtao Liu, Boyuan Fan, Haichang Wang
OBJECTIVE: Adropin, a newly identified regulatory protein encoded by Enho gene, suppressed tumor necrosis factor α-induced THP1 monocyte adhesion to human umbilical vein endothelial cells. In addition, inflammation is demonstrated to be involved in the mechanism of atrial fibrillation (AF). Atrial remodeling is correlated with the persistence and progression of AF. Adropin is hypothesized to correlated with AF and atrial remodeling. This study aims to determine the correlation of serum adropin and the presence of AF and remodeling...
September 21, 2018: Journal of Clinical Laboratory Analysis
Mounir Bouame, Mohamed Ali Lahmar, Mohamed Tahar Bouafia, Naima Hammoudi, Mohamed Tayeb Chentir, Mouloud Ait Athmane, Saïd Kara, Matthieu Trancart, Yildiz Levent, Jerome Cheynel, Redouane Soualmi
BACKGROUND: Atrial fibrillation (AF) is the most common cardiac arrhythmia, with substantial public health and economic impact on healthcare systems due to the prevention and management of thromboembolic and hemorrhagic complications. In Algeria, stroke is a leading cause of death, representing 15.6% of all deaths in 2012. Current data on the epidemiology and costs associated with non-valvular AF (NVAF) in Algeria are not available. METHODS: A three-step approach was undertaken to estimate the economic burden of NVAF in Algeria...
September 21, 2018: Journal of Medical Economics
Sefa Okar, Onur Kaypakli, Durmuş Yıldıray Şahin, Mevlüt Koç
BACKGROUND AND OBJECTIVES: We aimed to investigate the relationship between the recurrence of atrial fibrillation (AF) and fibrosis marker soluble ST2 (sST2) in patients with nonvalvular paroxysmal AF (PAF). METHODS: We prospectively included 100 consecutive patients with PAF diagnosis and scheduled for cryoballoon catheter ablation for AF (47 males, 53 females; mean age 55.1±10.8 years). sST2 plasma levels were determined using the ASPECT-PLUS assay on ASPECT Reader device (Critical Diagnostics)...
October 2018: Korean Circulation Journal
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