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https://www.readbyqxmd.com/read/27886163/alghedon-fentanyl-transdermal-system-afts
#1
Patrizia Romualdi, Patrizia Santi, Sanzio Candeletti
The efficacy of transdermal fentanyl for cancer pain and chronic non-cancer pain (chronic lower back pain, rheumatoid arthritis, osteoarthritis, neuropathic pain) is well established. Several formulations of fentanyl transdermal systems have been developed to improve the drug delivery and prevent misuse of the active principle. The addition of a rate controlling membrane to the matrix system represented an important advance. The design and functional features of Alghedon patch are compared with other approved generic fentanyl transdermal systems, emphasizing the distinctiveness of Alghedon patch...
November 25, 2016: Minerva Medica
https://www.readbyqxmd.com/read/27883222/alcohol-misuse-and-co-occurring-mental-disorders-among-new-soldiers-in-the-u-s-army
#2
Murray B Stein, Laura Campbell-Sills, Joel Gelernter, Feng He, Steven G Heeringa, Matthew K Nock, Nancy A Sampson, Xiaoying Sun, Sonia Jain, Ronald C Kessler, Robert J Ursano
BACKGROUND: Problem drinking that predates enlistment into military service may contribute to the overall burden of alcohol misuse in the Armed Forces; however, evidence bearing on this issue is limited. This study examines prevalence and correlates of alcohol misuse among new U.S. Army soldiers. METHODS: Cross-sectional survey data were collected from soldiers reporting for basic combat training. The survey retrospectively assessed lifetime alcohol consumption and substance abuse/dependence, enabling estimation of the prevalence of lifetime binge drinking and heavy drinking in a sample of 30,583 soldiers and of probable alcohol use disorder (AUD) among 26,754 soldiers with no/minimal lifetime use of other drugs...
November 24, 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27871180/prescription-opioid-prescribing-use-misuse-harms-and-treatment-among-aboriginal-people-in-canada-a-narrative-review-of-available-data-and-indicators
#3
Cayley Russell, Michelle Firestone, Len Kelly, Christopher Mushquash, Benedikt Fischer
INTRODUCTION: Prescription opioid (PO) misuse and related harms are high in Canada, and a major public health challenge. In Canada, 1.4 million individuals (4.3% of the total population) self-identify as Aboriginal, among whom substance use and related harms are elevated. While there are reports of PO use and associated problems among Aboriginal groups, no comprehensive data review currently exists. METHODS: A review of available data sources (ie journal publications, public reports and 'grey' literature) was conducted following principles of a scoping review...
October 2016: Rural and Remote Health
https://www.readbyqxmd.com/read/27848217/pregabalin-for-the-treatment-of-drug-and-alcohol-withdrawal-symptoms-a-comprehensive-review
#4
REVIEW
Rainer Freynhagen, Miroslav Backonja, Stephan Schug, Gavin Lyndon, Bruce Parsons, Stephen Watt, Regina Behar
Treatments for physical dependence and associated withdrawal symptoms following the abrupt discontinuation of prescription drugs (such as opioids and benzodiazepines), nicotine, alcohol, and cannabinoids are available, but there is still a need for new and more effective therapies. This review examines evidence supporting the potential use of pregabalin, an α2δ voltage-gated calcium channel subunit ligand, for the treatment of physical dependence and associated withdrawal symptoms. A literature search of the MEDLINE and Cochrane Library databases up to and including 11 December 2015 was conducted...
November 16, 2016: CNS Drugs
https://www.readbyqxmd.com/read/27805267/deficits-in-access-to-reward-are-associated-with-college-student-alcohol-use-disorder
#5
Keanan J Joyner, Alison M Pickover, Kathryn E Soltis, Ashley A Dennhardt, Matthew P Martens, James G Murphy
BACKGROUND: Reward deprivation has been implicated in major depressive disorder and severe substance abuse, but its potential relation to alcohol use disorder (AUD) symptoms in non-treatment-seeking young adult drinkers is less clear. Depression is often comorbid with alcohol misuse, so relations of AUD with reward deprivation might be due in part to the presence of depressive symptoms in young adults. Behavioral economic theory views addiction as a state that is related in part to deficits in drug-free rewards, and therefore requires an investigation into whether reward deprivation has a direct relation to alcohol misuse that is, at least partially, independent of mood...
December 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27796624/violence-trauma-mental-health-and-substance-use-among-homeless-youth-juggalos
#6
Robin Petering, Harmony Rhoades, Hailey Winetrobe, David Dent, Eric Rice
Insane Clown Posse is a musical duo whose fans are known as Juggalos. Many homeless youths (HY) identify as Juggalos, most likely because the group's music embraces poverty and being an outsider in mainstream society. Juggalos are stereotyped as being violent, undereducated, poor, racist, crime-committing youth, and in 2011 the FBI officially labeled Juggalos as a gang. However, little is known about the intersection of HY and Juggalos. A convenience sample of Los Angeles-area, drop-in service-seeking HY completed a self-administered questionnaire (N = 495)...
October 28, 2016: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/27780491/association-of-adverse-childhood-experiences-with-lifetime-mental-and-substance-use-disorders-among-men-and-women-aged-50-years
#7
Namkee G Choi, Diana M DiNitto, C Nathan Marti, Bryan Y Choi
BACKGROUND: Given growing numbers of older adults with mental and substance use disorders (MSUDs), this study examined the association between ten types of adverse childhood experiences (ACEs) and lifetime MSUDs among those aged 50+. METHODS: Data (N = 14,738 for the 50+ age group) came from the 2012 to 2013 National Epidemiologic Survey on Alcohol and Related Conditions. Using multivariable binary logistic regression analyses, we examined relationships between ten ACEs and six lifetime MSUDs (major depressive disorder (MDD) and anxiety, post-traumatic stress, alcohol use, drug use, and nicotine use disorders)...
October 26, 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27748174/positive-neonatal-urine-comprehensive-drug-screen-low-birth-weight-and-withdrawal-symptoms-in-a-neonatal-unit-a-case-control-study
#8
Kam Lun Hon, Michael Ho Ming Chan, Ming Him James Ng, Chi Cheung Ho, Yin Ching Kathy Tsang, Wing Hung Tam, Chung Shun Ho
OBJECTIVE: Maternal drug abuse may influence neonatal outcomes. We compared neonatal outcomes of patients with urine screened positive for commonly abused drugs (CAD) versus those who were screened negative, and reviewed the pattern of drugs detected at a university teaching hospital. METHODS: Urine samples collected from babies with suspected illicit drug exposure who were admitted to the neonatal unit were sent for comprehensive drug screen (CDS) performed by liquid chromatography-time-of-flight mass spectrometry (LC-TOF/MS)...
October 10, 2016: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/27720453/-new-patterns-of-substance-use-and-abuse-among-french-adolescents-a-knowledge-synthesis
#9
G Jeanne, D Purper-Ouakil, H Rigole, N Franc
AIM: There have been significant changes in adolescent consumption habits over the past fifteen years. New molecules have been synthesized, new devices created and a number of products have increased in popularity; and as a result clinicians sometimes lack information. We chose to focus on this population because of its vulnerability, as adolescents show low sensitivity to long-term outcomes of their actions and may be easily influenced by peers as regards experimentation of new drugs...
October 6, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27702963/controlled-substance-lock-in-programs-examining-an-unintended-consequence-of-a-prescription-drug-abuse-policy
#10
Andrew W Roberts, Joel F Farley, G Mark Holmes, Christine U Oramasionwu, Chris Ringwalt, Betsy Sleath, Asheley C Skinner
Controlled substance lock-in programs are garnering increased attention from payers and policy makers seeking to combat the epidemic of opioid misuse. These programs require high-risk patients to visit a single prescriber and pharmacy for coverage of controlled substance medication services. Despite high prevalence of the programs in Medicaid, we know little about their effects on patients' behavior and outcomes aside from reducing controlled substance-related claims. Our study was the first rigorous investigation of lock-in programs' effects on out-of-pocket controlled substance prescription fills, which circumvent the programs' restrictions and mitigate their potential public health benefits...
October 1, 2016: Health Affairs
https://www.readbyqxmd.com/read/27681087/-alcohol-and-substance-abuse-among-mentally-ill-patients-with-migration-background-in-austria
#11
Thomas Stompe, Kristina Ritter, David Holzer, Andrea Topitz, Thomas Wenzel
The refugee movements of the recent years are confronting the health care with new challenges. However, it has turned out that in Austria data on the mental health of migrants are nearly not available. Especially data on the frequency and patterns of comorbid substance abuse of migrants with mental disorders do not exist even from international studies. We analyzed data from 1819 patients (1726 first generation, 93 second generation) treated in the outpatient clinic for transcultural psychiatry and migration related disorders at the Vienna General Hospital: In first-generation migrants the cultural and religious background of the region of origin has the greatest impact on the frequency and the patterns of misused substances...
September 2016: Neuropsychiatrie: Klinik, Diagnostik, Therapie und Rehabilitation
https://www.readbyqxmd.com/read/27664597/interventions-for-adolescent-substance-abuse-an-overview-of-systematic-reviews
#12
REVIEW
Jai K Das, Rehana A Salam, Ahmed Arshad, Yaron Finkelstein, Zulfiqar A Bhutta
Many unhealthy behaviors often begin during adolescence and represent major public health challenges. Substance abuse has a major impact on individuals, families, and communities, as its effects are cumulative, contributing to costly social, physical, and mental health problems. We conducted an overview of systematic reviews to evaluate the effectiveness of interventions to prevent substance abuse among adolescents. We report findings from a total of 46 systematic reviews focusing on interventions for smoking/tobacco use, alcohol use, drug use, and combined substance abuse...
October 2016: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/27663805/understanding-the-prevalence-of-legal-high-misuse-in-early-adulthood
#13
Benedict Morris
With the recent introduction of the Psychoactive Substances Bill in the United Kingdom, it is a useful time to retrospectively review the patterns of prevalence of the psychoactive products known as 'Legal Highs'. There has been emerging research and rapidly expanding political, public and media attention and awareness, yet comparatively little scientific discourse on the psychological aspects driving their consumption, beyond simply their legal status. This paper focuses on their usage patterns in the particularly vulnerable, but often-neglected period of young adulthood between the ages of 16-24, focussing on their prevalence, trends in pharmacology and psychological aspects of their usage and propensity for addiction...
September 2016: Psychiatria Danubina
https://www.readbyqxmd.com/read/27637871/-which-psychiatric-comorbidities-in-cannabis-dependence-during-adolescence-comparison-of-outpatients-and-controls
#14
G Dorard, C Bungener, O Phan, Y Edel, M Corcos, S Berthoz
BACKGROUND: The use of illicit substances, in particular cannabis, among French adolescents and young adults has become an important public health concern. A better understanding of the mechanisms involved in pathological substance use is nowadays critical. Psychiatric comorbidities have been previously reported in adult substance abusers but are less documented in adolescents, especially regarding cannabis dependence. OBJECTIVES: We investigated mental health problems in adolescents and young adults, seeking treatment for their problematic cannabis use, comparatively to healthy controls, taking into account the participant's gender and age...
September 13, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27627570/correlates-of-abusing-and-misusing-over-the-counter-pain-relievers-among-adult-population-of-wroc%C3%A5-aw-poland
#15
Monika Wójta-Kempa, Dominik M Krzyżanowski
BACKGROUND: Almost 90% of households in Poland buy medicines on their own initiative. The most popular OTC medicines bought by Polish consumers are painkillers and non-steroid-anti-inflammatory drugs. OBJECTIVES: The aim of this article was to recognize and describe the most important predictive factors of the abuse and misuse of over-the-counter pain relievers among adults in Wrocław (Poland). The groups of users were selected and described. Some examples of misuse were analyzed...
March 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27627551/inter-personal-violence-and-abuse-in-adolescent-intimate-relationships-mental-health-impact-and-implications-for-practice
#16
Christine Barter, Nicky Stanley
This paper provides a narrative review of the knowledge on inter-personal violence and abuse (IPVA) in adolescents' intimate relationships. It draws on the authors' own research, published reviews, and a rapid review on IPVA victimization and mental health outcomes for adolescents. The research reviewed identified associations between adolescent IPVA and substance misuse, depressive symptoms and PTSD, eating disorders and suicidal thinking, and behaviour in young people. Generally, girls appeared more likely to report severe mental health outcomes than boys...
October 2016: International Review of Psychiatry
https://www.readbyqxmd.com/read/27624418/risky-use-and-misuse-of-alcohol-and-cigarettes-in-psychiatric-inpatients-a-screening-questionnaire-study
#17
Jacopo V Bizzarri, Valentina Casetti, Patrizia Panzani, Juliane Unterhauser, Stefania Mulas, Antonio Fanolla, Claudia Zitelli, Alessandro Briani, Giancarlo Giupponi, Icro Maremmani, Andreas Conca
BACKGROUND: Mental disorders are associated with an increased prevalence of substance use disorders (SUDs). Despite this comorbidity being firmly established, alcohol and nicotine risky use and misuse are not routinely and systematically assessed in clinical practice. OBJECTIVE: The aim of this study is to examine the prevalence of risky use of alcohol, alcohol use disorder (AUD), smoking, and nicotine use disorder in people with psychiatric diagnoses and their association with age, gender, and occupational functioning...
October 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27622169/family-risk-factors-among-women-with-addiction-related-problems-an-integrative-review
#18
REVIEW
Imaneh Abasi, Parvaneh Mohammadkhani
CONTEXT: Recent years have produced many articles about women's addiction and its risk factors and the consequences of substance use and misuse in the emotional, social, psychological, and economic domains of life. Family vulnerabilities are one of the most important variables contributing to addiction among women. Thus, the purpose of this article is to investigate areas of family life that lead to women's taking up and maintaining drug and alcohol abuse. EVIDENCE ACQUISITION: A database search of PubMed, ScienceDirect, Springer, and Google Scholar was conducted using the following keywords: "women and addiction", "women addiction and family", "addiction", "substance abuse" and "family"...
June 2016: International Journal of High Risk Behaviors & Addiction
https://www.readbyqxmd.com/read/27614056/the-drug-abuse-screening-test-preserves-its-excellent-psychometric-properties-in-psychiatric-patients-evaluated-in-an-emergency-setting
#19
Charles-Édouard Giguère, Stéphane Potvin
BACKGROUND: Substance use disorders (SUDs) are significant risk factors for psychiatric relapses and hospitalizations in psychiatric populations. Unfortunately, no instrument has been validated for the screening of SUDs in psychiatric emergency settings. The Drug Abuse Screening Test (DAST) is widely used in the addiction field, but is has not been validated in that particular context. The objective of the current study is to examine the psychometric properties of the DAST administered to psychiatric populations evaluated in an emergency setting...
August 31, 2016: Addictive Behaviors
https://www.readbyqxmd.com/read/27609330/prevalence-and-correlates-of-psychological-distress-symptoms-among-patients-with-substance-use-disorders-in-drug-rehabilitation-centers-in-urban-nepal-a-cross-sectional-study
#20
Bishal Gyawali, Bishnu P Choulagai, Damaru Prasad Paneru, Meraj Ahmad, Anja Leppin, Per Kallestrup
BACKGROUND: The burden of substance misuse in developing countries is large and increasing, with negative consequences for physical and psychological health. Substance use disorders and psychological distress commonly co-exist, however few studies have examined this relationship in developing countries, including Nepal. Our aim was to investigate the prevalence of psychological distress symptoms and associated factors among patients with substance use disorders attending drug rehabilitation centers in Nepal...
2016: BMC Psychiatry
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