Yu-Ting Wang, Qian-Hui Wu, Liang Chen, John P Giesy, Lin-Lin Xu, Wen-Li Xu, Jun He, Ting Shi, Yi-Qing Liu, Shi-Man Xiao, Ye-Ke Wang, Feng Chen, Yang Chen, Ning-Hui Xu, Ya-Li Ge, Ling Chu, Yun-Zhi Yan, Jun Chen, Ping Xie
Microcystins (MCs) can cause reproductive and developmental toxicity and disrupt endocrine homeostasis in mammals. In the present study, male, Sprague-Dawley (SD) rats were administrated 3 or 30 μg MC-LR/kg, body mass (bm) per day via intraperitoneal (i.p.) injections for 6 weeks. Effects of MC-LR on histology, hormone concentrations, gene transcriptional profiles and protein expressions along the hypothalamic-pituitary-adrenal (HPA), -gonad (HPG) and -thyroid (HPT) axes were assessed. Sub-chronic administration with MC-LR caused histological damage to hypothalamus, pituitary, adrenal, testes and thyroid and affected relative masses of pituitary, adrenal and testes...
September 8, 2023: Science of the Total Environment