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oppen neurology

Peter L Remijnse, Marjan M A Nielen, Anton J L M van Balkom, Daniƫlle C Cath, Patricia van Oppen, Harry B M Uylings, Dick J Veltman
CONTEXT: The orbitofrontal cortex (OFC)-striatal circuit, which is important for motivational behavior, is assumed to be involved in the pathophysiology of obsessive-compulsive disorder (OCD) according to current neurobiological models of this disorder. However, the engagement of this neural loop in OCD has not been tested directly in a cognitive activation imaging paradigm so far. OBJECTIVE: To determine whether the OFC and the ventral striatum show abnormal neural activity in OCD during cognitive challenge...
November 2006: Archives of General Psychiatry
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