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Neonatal stoke

Victoria Stokes, Caroline Fertleman
We report two cases of 21-day-old male infants, Baloo and Bagheera, both admitted with unilateral reduced arm movement secondary to painful lymphadenopathy, which is a presentation previously unreported in the paediatric literature. The only abnormal finding following investigations in both neonates was infective lymphadenopathy; we hypothesise that the inflamed lymph nodes were tender when the surrounding muscles, fascia or skin were moved, so that the infants learnt to reduce arm movement to minimise pain...
2015: BMJ Case Reports
Katie Watson, Theophil A Stokes
No abstract text is available yet for this article.
May 2015: Acta Paediatrica
Ashleigh R Pavey, Gregory H Gorman, Devon Kuehn, Theophil A Stokes, Elizabeth Hisle-Gorman
OBJECTIVE: To determine the effect of intimate partner violence (IPV) on birth outcomes and infant hospitalization. STUDY DESIGN: Hospitalization records for the first 4 months of life for infants born in the Military Health System in 2006-2007 were linked to Family Advocacy Program-substantiated cases of IPV among military parents. Adverse outcomes were identified using International Classification of Diseases, Ninth Revision codes. Logistic regression modeling calculated the OR of children exposed to IPV experiencing adverse outcomes...
November 2014: Journal of Pediatrics
Ilvana Ziko, Simone De Luca, Tara Dinan, Joanne M Barwood, Luba Sominsky, Guohui Cai, Rachel Kenny, Leanne Stokes, Trisha A Jenkins, Sarah J Spencer
The early life period is one of significant vulnerability to programming effects from the environment. Given the sensitivity of microglial cells to early life programming and to adult diet, we hypothesized overfeeding during the neonatal period would acutely alter microglial profiles within the developing brain, predisposing the individual to a lasting central pro-inflammatory profile that contributes to overactive immune responses long-term. We tested this idea by manipulating litter sizes in which Wistar rat pups were raised, so the pups were suckled in litters of 4 (neonatally overfed) or 12 (control)...
October 2014: Brain, Behavior, and Immunity
Theophil A Stokes, Katie L Watson, Renee D Boss
Counseling a family confronted with the birth of a periviable neonate is one of the most difficult tasks that a neonatologist must perform. The neonatologist's goal is to facilitate an informed, collaborative decision about whether life-sustaining therapies are in the best interest of this baby. Neonatologists are trained to provide families with a detailed account of the morbidity and mortality data they believe are necessary to facilitate a truly informed decision. Yet these complicated and intensely emotional conversations require advanced communication and counseling skills that our current fellowship-training strategies are not adequately providing...
February 2014: Seminars in Perinatology
Dalia Feltman, Theophil Stokes, Jennifer Kett, John D Lantos
Doctors have no ethical obligation to provide futile treatment. This has been true since the time of Hippocrates who warned physicians not to treat patients who were "overmastered by their disease." This principle remains valid today but, as the Society for Critical Care Medicine notes, it is difficult to identify treatment as absolutely futile in all but a few clinical situations. Far more common, they note, are "treatments that are extremely unlikely to be beneficial, are extremely costly, or are of uncertain benefit...
January 2014: Pediatrics
Michal Mielcarek, Tamara Seredenina, Matthew P Stokes, Georgina F Osborne, Christian Landles, Linda Inuabasi, Sophie A Franklin, Jeffrey C Silva, Ruth Luthi-Carter, Vahri Beaumont, Gillian P Bates
Reversible protein acetylation provides a central mechanism for controlling gene expression and cellular signaling events. It is governed by the antagonistic commitment of two enzymes families: the histone acetyltransferases (HATs) and the histone deacetylases (HDACs). HDAC4, like its class IIa counterparts, is a potent transcriptional repressor through interactions with tissue specific transcription factors via its N-terminal domain. Whilst the lysine deacetylase activity of the class IIa HDACs is much less potent than that of the class I enzymes, HDAC4 has been reported to influence protein deacetylation through its interaction with HDAC3...
2013: PloS One
Chun-Shan Liu, Tae-Gyu Nam, Min-Woo Han, Soo-mi Ahn, Han Seok Choi, Tae Young Kim, Ock K Chun, Sung I Koo, Dae-Ok Kim
Oxidative stress due to the over-production of reactive oxygen species (ROS) is associated with human skin aging. This study was designed to identify the bioactive phenolics in detoxified Rhus verniciflua Stokes (DRVS) that may protect human skin against oxidative stress. Under oxidative stress caused by H₂O₂, the 40% (v/v) aqueous methanol extract of DRVS protected human keratinocytes in a dose-dependent manner. The expression of matrix metalloproteinase-1 (MMP-1) was also inhibited by the DRVS extract in human dermal fibroblasts-neonatal cells exposed to ultraviolet A...
2013: Bioscience, Biotechnology, and Biochemistry
Colin K L Phoon, Devrim Acehan, Michael Schlame, David L Stokes, Irit Edelman-Novemsky, Dawen Yu, Yang Xu, Nitya Viswanathan, Mindong Ren
BACKGROUND: Barth syndrome is a rare, multisystem disorder caused by mutations in tafazzin that lead to cardiolipin deficiency and mitochondrial abnormalities. Patients most commonly develop an early-onset cardiomyopathy in infancy or fetal life. METHODS AND RESULTS: Knockdown of tafazzin (TAZKD) in a mouse model was induced from the start of gestation via a doxycycline-inducible shRNA transgenic approach. All liveborn TAZKD mice died within the neonatal period, and in vivo echocardiography revealed prenatal loss of TAZKD embryos at E12...
April 2012: Journal of the American Heart Association
Lance Rodan, Brian W McCrindle, Cedric Manlhiot, Daune L MacGregor, Rand Askalan, Mahendra Moharir, Gabrielle deVeber
OBJECTIVE: Pediatric arterial ischemic stroke (AIS) carries an important morbidity and mortality burden. Congenital heart disease (CHD) is among the most important risk factors for pediatric AIS. Data on stroke recurrence in childhood CHD are lacking, resulting in uncertainty regarding optimal strategies for preventing recurrence. METHODS: In the Canadian Pediatric Ischemic Stroke Registry-Toronto site, we identified children (birth to 18 years) with CHD diagnosed with AIS during 1992-2008...
July 2012: Annals of Neurology
Kerry M Empey, Jacob G Orend, R Stokes Peebles, Loreto Egaña, Karen A Norris, Tim D Oury, Jay K Kolls
Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and viral death in infants. Reduced CD8 T-cells and negligible interferon gamma (IFNγ) in the airway are associated with severe infant RSV disease, yet there is an abundance of alveolar macrophages (AM) and neutrophils. However, it is unclear, based on our current understanding of macrophage functional heterogeneity, if immature AM improve viral clearance or contribute to inflammation and airway obstruction in the IFNγ-deficient neonatal lung environment...
2012: PloS One
Amy B Clark, Theophil A Stokes, Henry F Krous, Douglas N Carbine
Neonatal myocardial infarction secondary to congenital heart disease, anomalous coronary artery anatomy, thromboembolism, coagulopathy, birth asphyxia, and unknown causes has been previously reported. We now report an infant who suffered a massive myocardial infarction during birth, requiring extensive resuscitation and aggressive management. A thrombus, the origin of which was not detected on autopsy, was found occluding the proximal left coronary artery several hours after birth. Genetic studies revealed a single copy variant of the MTHFR C677T mutation that we speculate may have predisposed the infant to coronary thrombosis...
May 2012: Pediatric and Developmental Pathology
Marie C Lewis, Charlotte F Inman, Dilip Patel, Bettina Schmidt, Imke Mulder, Bevis Miller, Bhupinder P Gill, John Pluske, Denise Kelly, Christopher R Stokes, Michael Bailey
BACKGROUND:   In mammals, early-life environmental variations appear to affect microbial colonization and therefore competent immune development, and exposure to farm environments in infants has been inversely correlated with allergy development. Modelling these effects using manipulation of neonatal rodents is difficult due to their dependency on the mother, but the relatively independent piglet is increasingly identified as a valuable translational model for humans. This study was designed to correlate immune regulation in piglets with early-life environment...
May 2012: Pediatric Allergy and Immunology
Douglas L Blowey, Patti J Duda, Peggy Stokes, Matthew Hall
The incidence and risk factors for hypertension in the neonatal intensive care unit (NICU) is inadequately defined, and the current utilization of antihypertensive medications in this specialized environment is not known. We evaluated the incidence of hypertension, associated risk factors, and utilization of antihypertensive drugs in the NICU using a large, geographically diverse pediatric database. A total of 123,847 NICU encounters were identified in the database. After exclusion of the 44,861 neonates with congenital cardiac disorders, 764 (1%) were coded with the diagnosis of hypertension...
November 2011: Journal of the American Society of Hypertension: JASH
A A Afaq, S Stokes, H Fareed, H G Zadeh, M Watson
INTRODUCTION: Developmental dysplasia of the hip (DDH) can result in chronic pain, gait abnormalities and degenerative arthritis. Infants with a family history, Breech delivery or unstable/"clicking" of the hip on examination are at higher risk. The goal is to detect cases early enough for normal hip development and function by the end of adolescence, but clinical examination alone is ineffective. MATERIALS AND METHODS: All infants born at the West Middlesex University Hospital, Isle-worth, U...
April 2011: European Review for Medical and Pharmacological Sciences
Stacey E Applegate, D Scott Lim
OBJECTIVES: The aim of this study was to investigate the incidence of stoke in pediatric patients undergoing a balloon atrial septostomy (BAS). BACKGROUND: Newborn infants with d-transposition of the great arteries (dTGA) can be compromised from significant hypoxemia due to inadequate mixing at the atrial level. BAS can be lifesaving by improving the intra-atrial mixing. BAS, although life-saving, is associated with risks including arrhythmias, infection, bleeding, stroke, or death...
July 1, 2010: Catheterization and Cardiovascular Interventions
Charlotte F Inman, Sakon Singha, Marie Lewis, Ben Bradley, Chris Stokes, Mick Bailey
Absence of lymph nodes in nonmammalian species, expression of MHCII by APCs in the periphery, and the recent findings that T cells can change their polarization status after presentation in the lymph nodes imply a role for MHCII-mediated presentation outside the organized lymphoid tissue. This study shows that MHCII(+) ECs and DCs from the intestinal mucosa of the pig can present antigen to T cells in vitro. In vivo, APCs colocalize with T cells in pig and mouse intestinal mucosa. In the pig, endothelium is involved in these interactions in neonates but not in adults, indicating different roles for stromal and professional APCs in the neonate compared with the adult...
September 2010: Journal of Leukocyte Biology
Teresa Wright
No abstract text is available yet for this article.
July 2010: Journal of the Royal Society of Medicine
C F Inman, K Haverson, S R Konstantinov, P H Jones, C Harris, H Smidt, B Miller, M Bailey, C Stokes
Early-life exposure to appropriate microbial flora drives expansion and development of an efficient immune system. Aberrant development results in increased likelihood of allergic disease or increased susceptibility to infection. Thus, factors affecting microbial colonization may also affect the direction of immune responses in later life. There is a need for a manipulable animal model of environmental influences on the development of microbiota and the immune system during early life. We assessed the effects of rearing under low- (farm, sow) and high-hygiene (isolator, milk formula) conditions on intestinal microbiota and immune development in neonatal piglets, because they can be removed from the mother in the first 24 h for rearing under controlled conditions and, due to placental structure, neither antibody nor antigen is transferred in utero...
June 2010: Clinical and Experimental Immunology
P Johnelle Sparks, Diane K McLaughlin, C Shannon Stokes
PURPOSE: To examine differences in correlates of neonatal and postneonatal infant mortality rates, across counties, by degree of rurality. METHODS: Neonatal and postneonatal mortality rates were calculated from the 1998 to 2002 Compressed Mortality Files from the National Center for Health Statistics. Bivariate analyses assessed the relationship between neonatal and postneonatal mortality by Urban Influence (UI) codes. Multivariable, weighted least-squares regression models included measures of county socioeconomic conditions, health services and environmental risks...
2009: Journal of Rural Health
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