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JOURNAL ARTICLE
Rafael González, Javier Urbano, Jesús López-Herce
PURPOSE OF REVIEW: This review summarizes current literature about the relationships between macro and microcirculation and their practical clinical implications in children with septic shock. RECENT FINDINGS: Current evidence from experimental and clinical observational studies in children and adults with septic shock reveals that the response to treatment and resuscitation is widely variable. Furthermore, there is a loss of hemodynamic coherence, as resuscitation-induced improvement in macrocirculation (systemic hemodynamic parameters) does not necessarily result in a parallel improvement in the microcirculation...
March 5, 2024: Current Opinion in Pediatrics
#22
Haiyang Zhang, Zhongqiang Liu, Yuanlin Guan, Deyuan Li, Hanmin Liu, Lingying Ruan
Fusobacterium necrophorum ( F. necrophorum ) infection is rare in pediatrics. In addition, the detection time of F. necrophorum by blood culture is long, and the positive rate is low. Infection with F. necrophorum bacilli usually follows rapid disease progression, resulting in high mortality. In previous reports of F. necrophorum -related cases, the most dangerous moment of the disease occurred after the appearance of Lemierre's syndrome. We report an atypical case of a 6-year-old female patient who developed septic shock within 24 h of admission due to F...
2024: Frontiers in Cellular and Infection Microbiology
#23
MULTICENTER STUDY
Amani N Alansari, Temur Baykuziyev, Tutku Soyer, Servet Melike Akıncı, Khalid Khalfan Al Ali, Adel Aljneibi, Nafea Hussain Alyasi, Muhammad Afzal, Amine Ksia
Over the past 15 years, there has been a noticeable uptick in incidents involving children ingesting multiple magnetic foreign bodies which can cause injuries and gastrointestinal complications including death. The current study aimed to identify the prevalence, clinical presentation, and management of single or multiple magnet ingestions. A retrospective multi-central cross-sectional study was conducted to include all pediatric patients < 18 years presented to the emergency department with ingestion of single or multiple magnets and admitted across hospitals in Qatar, UAE, KSA, Tunisia, and Turkey between January 2011 and December 2021...
February 25, 2024: Scientific Reports
#24
JOURNAL ARTICLE
G Liu, C M Zhang, Y Li, J Y Sun, Y B Cheng, Y P Chen, Z H Wang, H Ren, C F Liu, Y P Jin, S Chen, X M Wang, F Xu, X Z Xu, Q J Zhu, X D Wang, X H Liu, Y Liu, Y Hu, W Wang, Q Ai, H X Dang, H M Gao, C N Fan, S Y Qian
Objective: To investigate respiratory virus infection in children with septic shock in pediatric care units (PICU) in China and its influence on clinical outcomes. Methods: The clinical data of children with septic shock in children's PICU from January 2018 to December 2019 in 10 Chinese hospitals were retrospectively collected. They were divided into the pre-COVID-19 and post-COVID-19 groups according to the onset of disease, and the characteristics and composition of respiratory virus in the 2 groups were compared...
March 2, 2024: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
#25
JOURNAL ARTICLE
Aurélie Portefaix, Carole Dhelens, Morgan Recher, Fleur Cour-Andlauer, Jérôme Naudin, Guillaume Mortamet, Nicolas Joram, Pierre Tissières, Tiphanie Ginhoux, Behrouz Kassai, Florent Boutitie, Delphine Maucort-Boulch, Etienne Javouhey
PURPOSE: Toxic shock syndrome (TSS) is a rare disease responsible for significant morbidity and mortality. Intravenous immunoglobulin (IG) therapy in paediatric TSS could improve shock and organ failure, but more consistent efficacy and safety data are needed. Our objective was to determine whether a randomised clinical trial (RCT) assessing intravenous IG in TSS in children is feasible. METHODS: We performed a multicentre, feasibility, double-blind RCT assessing efficacy of high-dose intravenous IG versus albumin 4% (control group) within the first 12 hours of shock onset...
February 15, 2024: Archives of Disease in Childhood
#26
JOURNAL ARTICLE
Clara Vigneron, Clara Timsit, Jean-Paul Mira
No abstract text is available yet for this article.
October 2023: La Revue du Praticien
#27
JOURNAL ARTICLE
Rong Liu, Zhicai Yu, Changxue Xiao, Feng Xu, Shufang Xiao, Juan He, Yan Shi, Yuanyuan Hua, Jimin Zhou, Guoying Zhang, Tao Wang, Jianyu Jiang, Daoxue Xiong, Yan Chen, Hongbo Xu, Hong Yun, Hui Sun, Tingting Pan, Rui Wang, Shuangmei Zhu, Dong Huang, Yujiang Liu, Yuhang Hu, Xinrui Ren, Mingfang Shi, Sizun Song, Jumei Luo, Gang He, Juan Zhang
OBJECTIVES: To describe the epidemiological characteristics of pediatric sepsis in Southwest China PICUs. DESIGN: A prospective, multicenter, and observational study. SETTING: Twelve PICUs in Southwest China. PATIENTS: The patients admitted to the PICU from April 1, 2022, to March 31, 2023. The age ranged from 28 days to 18 years. All patients met the criteria of severe sepsis or septic shock. INTERVENTIONS: None...
February 14, 2024: Pediatric Critical Care Medicine
#28
JOURNAL ARTICLE
Grace E Logan, Russell K Banks, Ron Reeder, Kristen Miller, Peter M Mourani, Tellen D Bennett, Stephanie L Bourque, Kathleen L Meert, Jerry Zimmerman, Aline B Maddux
OBJECTIVES: To develop a desirability of outcome ranking (DOOR) scale for use in children with septic shock and determine its correlation with a decrease in 3-month postadmission health-related quality of life (HRQL) or death. DESIGN: Secondary analysis of the Life After Pediatric Sepsis Evaluation prospective study. SETTING: Twelve U.S. PICUs, 2013-2017. PATIENTS: Children (1 mo-18 yr) with septic shock. INTERVENTIONS: None...
February 14, 2024: Pediatric Critical Care Medicine
#29
JOURNAL ARTICLE
Hong Yul An, Hyoung Jin Kang, June Dong Park
BACKGROUND: In this study, we reviewed the outcomes of pediatric patients with malignancies who underwent hematopoietic stem cell transplantation (HSCT) and extracorporeal membrane oxygenation (ECMO). METHODS: We retrospectively analyzed the records of pediatric hemato-oncology patients treated with chemotherapy or HSCT and who received ECMO in the pediatric intensive care unit (PICU) at Seoul National University Children's Hospital from January 2012 to December 2020...
February 2024: Acute and critical care
#30
Hanan Nazir, Mathew Zachariah, Laila Al Yazidi
Adenovirus infections are common and self-limiting in young children except those with compromised cellular immunity. However, serious adenovirus infections are rare in children with acute leukemia. We report a rare case of a toddler with acute myeloid leukemia who developed a disseminated adenoviral infection complicated by hemorrhagic enterocolitis and septic shock that led to a fatal outcome.
November 2023: Oman Medical Journal
#31
JOURNAL ARTICLE
L Nelson Sanchez-Pinto, Tellen D Bennett, Peter E DeWitt, Seth Russell, Margaret N Rebull, Blake Martin, Samuel Akech, David J Albers, Elizabeth R Alpern, Fran Balamuth, Melania Bembea, Mohammod Jobayer Chisti, Idris Evans, Christopher M Horvat, Juan Camilo Jaramillo-Bustamante, Niranjan Kissoon, Kusum Menon, Halden F Scott, Scott L Weiss, Matthew O Wiens, Jerry J Zimmerman, Andrew C Argent, Lauren R Sorce, Luregn J Schlapbach, R Scott Watson, Paolo Biban, Enitan Carrol, Kathleen Chiotos, Claudio Flauzino De Oliveira, Mark W Hall, David Inwald, Paul Ishimine, Michael Levin, Rakesh Lodha, Simon Nadel, Satoshi Nakagawa, Mark J Peters, Adrienne G Randolph, Suchitra Ranjit, Daniela Carla Souza, Pierre Tissieres, James L Wynn
IMPORTANCE: The Society of Critical Care Medicine Pediatric Sepsis Definition Task Force sought to develop and validate new clinical criteria for pediatric sepsis and septic shock using measures of organ dysfunction through a data-driven approach. OBJECTIVE: To derive and validate novel criteria for pediatric sepsis and septic shock across differently resourced settings. DESIGN, SETTING, AND PARTICIPANTS: Multicenter, international, retrospective cohort study in 10 health systems in the US, Colombia, Bangladesh, China, and Kenya, 3 of which were used as external validation sites...
February 27, 2024: JAMA
#32
JOURNAL ARTICLE
Luregn J Schlapbach, R Scott Watson, Lauren R Sorce, Andrew C Argent, Kusum Menon, Mark W Hall, Samuel Akech, David J Albers, Elizabeth R Alpern, Fran Balamuth, Melania Bembea, Paolo Biban, Enitan D Carrol, Kathleen Chiotos, Mohammod Jobayer Chisti, Peter E DeWitt, Idris Evans, Cláudio Flauzino de Oliveira, Christopher M Horvat, David Inwald, Paul Ishimine, Juan Camilo Jaramillo-Bustamante, Michael Levin, Rakesh Lodha, Blake Martin, Simon Nadel, Satoshi Nakagawa, Mark J Peters, Adrienne G Randolph, Suchitra Ranjit, Margaret N Rebull, Seth Russell, Halden F Scott, Daniela Carla de Souza, Pierre Tissieres, Scott L Weiss, Matthew O Wiens, James L Wynn, Niranjan Kissoon, Jerry J Zimmerman, L Nelson Sanchez-Pinto, Tellen D Bennett
IMPORTANCE: Sepsis is a leading cause of death among children worldwide. Current pediatric-specific criteria for sepsis were published in 2005 based on expert opinion. In 2016, the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) defined sepsis as life-threatening organ dysfunction caused by a dysregulated host response to infection, but it excluded children. OBJECTIVE: To update and evaluate criteria for sepsis and septic shock in children...
January 21, 2024: JAMA
#33
JOURNAL ARTICLE
Jaime Fernández-Sarmiento, Shirley Lamprea, Sofia Barrera, Lorena Acevedo, Catalina Duque, Manuela Trujillo, Valeria Aguirre, Carolina Jimenez
BACKGROUNDS: In children with sepsis, circulatory shock and multi-organ failure remain major contributors to mortality. Prolonged capillary refill time (PCRT) is a clinical tool associated with disease severity and tissue hypoperfusion. Microcirculation assessment with videomicroscopy represents a promising candidate for assessing and improving hemodynamic management strategies in children with sepsis. Particularly when there is loss of coherence between the macro and microcirculation (hemodynamic incoherence)...
January 20, 2024: BMC Pediatrics
#34
JOURNAL ARTICLE
Brett McWhinney, Jacobus Ungerer, Renate LeMarsey, Natalie Phillips, Sainath Raman, Kristen Gibbons, Luregn J Schlapbach
OBJECTIVES: Vitamin C and thiamin have been trialed as adjunctive therapies in adults with septic shock but their role in critically ill children is unclear. We assessed serum levels of vitamin C and thiamin in children evaluated for sepsis. DESIGN: Single-center prospective observational study. Serum levels of vitamin C and thiamin were measured on admission and association with multiple organ dysfunction syndrome (MODS) was explored using logistic regression. SETTING: Emergency department and PICU in a tertiary children's hospital, Queensland, Australia...
February 1, 2024: Pediatric Critical Care Medicine
#35
RANDOMIZED CONTROLLED TRIAL
Luregn J Schlapbach, Sainath Raman, David Buckley, Shane George, Megan King, Roberta Ridolfi, Amanda Harley, Michele Cree, Debbie Long, Simon Erickson, Puneet Singh, Marino Festa, Kristen Gibbons, Rinaldo Bellomo
OBJECTIVES: Adjunctive therapy with vitamin C, hydrocortisone, and thiamin has been evaluated in adults, but randomized controlled trial (RCT) data in children are lacking. We aimed to test the feasibility of vitamin C, hydrocortisone, and thiamin in PICU patients with septic shock; and to explore whether the intervention is associated with increased survival free of organ dysfunction. DESIGN: Open-label parallel, pilot RCT multicenter study. The primary endpoint was feasibility...
February 1, 2024: Pediatric Critical Care Medicine
#36
RANDOMIZED CONTROLLED TRIAL
Amanda Harley, Shane George, Natalie Phillips, Megan King, Debbie Long, Gerben Keijzers, Paula Lister, Sainath Raman, Rinaldo Bellomo, Kristen Gibbons, Luregn J Schlapbach
OBJECTIVES: In children with septic shock, guidelines recommend resuscitation with 40-60 mL/kg of fluid boluses, yet there is a lack of evidence to support this practice. We aimed to determine the feasibility of a randomized trial comparing early adrenaline infusion with standard fluid resuscitation in children with septic shock. DESIGN: Open-label parallel randomized controlled, multicenter pilot study. The primary end point was feasibility; the exploratory clinical endpoint was survival free of organ dysfunction by 28 days...
February 1, 2024: Pediatric Critical Care Medicine
#37
JOURNAL ARTICLE
Dipayan Chaudhuri, Andrea M Nei, Bram Rochwerg, Robert A Balk, Karim Asehnoune, Rhonda Cadena, Joseph A Carcillo, Ricardo Correa, Katherine Drover, Annette M Esper, Hayley B Gershengorn, Naomi E Hammond, Namita Jayaprakash, Kusum Menon, Lama Nazer, Tyler Pitre, Zaffer A Qasim, James A Russell, Ariel P Santos, Aarti Sarwal, Joanna Spencer-Segal, Nejla Tilouche, Djillali Annane, Stephen M Pastores
RATIONALE: New evidence is available examining the use of corticosteroids in sepsis, acute respiratory distress syndrome (ARDS) and community-acquired pneumonia (CAP), warranting a focused update of the 2017 guideline on critical illness-related corticosteroid insufficiency. OBJECTIVES: To develop evidence-based recommendations for use of corticosteroids in hospitalized adults and children with sepsis, ARDS, and CAP. PANEL DESIGN: The 22-member panel included diverse representation from medicine, including adult and pediatric intensivists, pulmonologists, endocrinologists, nurses, pharmacists, and clinician-methodologists with expertise in developing evidence-based Clinical Practice Guidelines...
January 19, 2024: Critical Care Medicine
#38
JOURNAL ARTICLE
Mihir R Atreya, Natalie Z Cvijanovich, Julie C Fitzgerald, Scott L Weiss, Michael T Bigham, Parag N Jain, Kamal Abulebda, Riad Lutfi, Jeffrey Nowak, Neal J Thomas, Torrey Baines, Michael Quasney, Bereketeab Haileselassie, Rashmi Sahay, Bin Zhang, Matthew N Alder, Natalja L Stanski, Stuart L Goldstein
OBJECTIVES: Post-ICU admission cumulative positive fluid balance (PFB) is associated with increased mortality among critically ill patients. We sought to test whether this risk varied across biomarker-based risk strata upon adjusting for illness severity, presence of severe acute kidney injury (acute kidney injury), and use of continuous renal replacement therapy (CRRT) in pediatric septic shock. DESIGN: Ongoing multicenter prospective observational cohort. SETTING: Thirteen PICUs in the United States (2003-2023)...
January 2024: Critical care explorations
#39
JOURNAL ARTICLE
Oren Tamary, Arnon Yaari, Zafnat Prokocimer-Yair, Roi Feldman, Ron Berant, Ron Jacob, Nir Samuel
OBJECTIVE: Pigtail thoracostomy (PT) has become the mainstay technique for the drainage of pediatric pleuropneumonic effusions (PLPe). However, its efficacy and complication profile has been questioned when compared with video-assisted thoracoscopic surgery and larger bore traditional tube thoracostomy. The aim of this study was to assess the efficacy, safety, and complications associated with PT. METHODS: A cross-sectional study at a freestanding tertiary children's hospital...
January 16, 2024: Pediatric Emergency Care
#40
JOURNAL ARTICLE
Aline B Maddux, Kristen R Miller, Yamila L Sierra, Tellen D Bennett, R Scott Watson, Matthew Spear, Laura L Pyle, Peter M Mourani
OBJECTIVES: To characterize health-related quality of life (HRQL) and functional recovery trajectories and risk factors for prolonged impairments among critically ill children receiving greater than or equal to 3 days of invasive ventilation. DESIGN: Prospective cohort study. SETTING: Quaternary children's hospital PICU. PATIENTS: Children without a preexisting tracheostomy who received greater than or equal to 3 days of invasive ventilation, survived hospitalization, and completed greater than or equal to 1 postdischarge data collection...
May 1, 2024: Critical Care Medicine
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