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https://www.readbyqxmd.com/read/27703051/application-of-slicc-classification-criteria-in-undifferentiated-connective-tissue-disease-and-evolution-in-systemic-lupus-erythematosus-analysis-of-a-large-monocentric-cohort-with-a-long-term-follow-up
#1
A Bortoluzzi, F Furini, F Campanaro, M Govoni
OBJECTIVES: The objectives of this study were to analyse the performance of the Systemic Lupus International Collaborating Clinics (SLICC) 2012 classification criteria for systemic lupus erythematosus (SLE) in a large cohort of undifferentiated connective tissue disease (UCTD) population at onset of the disease and during a long-term follow-up of 15 years (1999-2013) and to evaluate the transition from UCTD to SLE, according to American College of Rheumatology (ACR) 1997 and SLICC 2012 classification criteria...
October 4, 2016: Lupus
https://www.readbyqxmd.com/read/27650429/cxcl4-in-undifferentiated-connective-tissue-disease-at-risk-for-systemic-sclerosis-ssc-previously-referred-to-as-very-early-ssc
#2
Gabriele Valentini, Antonella Riccardi, Serena Vettori, Rosaria Irace, Michele Iudici, Salvatore Tolone, Ludovico Docimo, Marialuisa Bocchino, Alessandro Sanduzzi, Domenico Cozzolino
The aim of the study was to evaluate CXCL4 levels in undifferentiated connective tissue disease at risk for SSc (UCTD-SSc-risk) and confirm its increase and investigate its prognostic value. Serum CXCL4 levels were measured in 45 patients and 24 controls. CXCL4 was significantly higher in UCTD-SSc-risk patients than in controls. It resulted higher in patients with a shorter disease duration and in those lacking capillaroscopic alterations. We confirm that CXCL4 levels are increased in UCTD-risk-SSc patients...
September 20, 2016: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/27458514/development-of-systemic-sclerosis-in-patients-with-autoimmune-hepatitis-an-emerging-overlap-syndrome
#3
Roberto Assandri, Marta Monari, Alessandro Montanelli
AIM: We described two case reports of AIH/SSc overlap syndrome and reviewed literatures regarding this issue. BACKGROUND: AIH is a chronic hepatitis of unknown aetiology characterized by continuing hepatocellular necrosis and inflammation. AIH overlap syndromes have been reported with other autoimmune diseases. PATIENTS AND METHODS: According to the classification criteria for SSc, we conducted a retrospective chart review of 35 cases with biopsy-proven AIH over the past 5 years at our institution...
2016: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/27427300/the-clinical-impact-of-anti-dfs70-antibodies-in-undifferentiated-connective-tissue-disease-case-reports-and-a-review-of-the-literature
#4
M Infantino, F Meacci, V Grossi, M Manfredi, F Li Gobbi, P Sarzi-Puttini, F Atzeni, M Benucci
Anti-nuclear antibody (ANA) positivity suggests CTD but can also lead to a diagnosis of UCTD when a patient does not fulfill the CTD diagnostic criteria. An anti-dense fine speckled (DFS) immunofluorescence (IIF) pattern can be observed when using an ANA test on HEp-2 cells and is due to the presence of antibodies to the nuclear DFS70 antigen that has rarely found in CTD. Serological testing for anti-DFS70 antibodies could therefore play a very interesting negative predictive role in stratifying patients on the basis of the evolution of UCTD to CTD...
July 18, 2016: Immunologic Research
https://www.readbyqxmd.com/read/27103387/characterisation-of-patients-with-interstitial-pneumonia-with-autoimmune-features
#5
Justin M Oldham, Ayodeji Adegunsoye, Eleanor Valenzi, Cathryn Lee, Leah Witt, Lena Chen, Aliya N Husain, Steven Montner, Jonathan H Chung, Vincent Cottin, Aryeh Fischer, Imre Noth, Rekha Vij, Mary E Strek
Patients with interstitial lung disease (ILD) may have features of connective tissue disease (CTD), but lack findings diagnostic of a specific CTD. A recent European Respiratory Society/American Thoracic Society research statement proposed criteria for patients with interstitial pneumonia with autoimmune features (IPAF).We applied IPAF criteria to patients with idiopathic interstitial pneumonia and undifferentiated CTD-ILD (UCTD). We then characterised the clinical, serological and morphological features of the IPAF cohort, compared outcomes to other ILD cohorts and validated individual IPAF domains using survival as an endpoint...
June 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/26950897/connective-tissue-diseases-and-autoimmune-thyroid-disorders-in-the-first-trimester-of-pregnancy
#6
Fausta Beneventi, Elena Locatelli, Roberto Caporali, Claudia Alpini, Elisabetta Lovati, Véronique Ramoni, Margherita Simonetta, Chiara Cavagnoli, Carlomaurizio Montecucco, Arsenio Spinillo
OBJECTIVE: To investigate the rates and coexistence of autoimmune thyroid and connective tissue diseases (CTD) during the first trimester of pregnancy and their influence on pregnancy outcome. STUDY DESIGN: A cohort study of 150 women with CTD diagnosed during first trimester of pregnancy and 150 negative controls. MAIN OUTCOME MEASURES: Screening of CTD by a self-reported questionnaire, rheumatic and thyroid autoantibody detection, clinical rheumatological evaluation and obstetric outcomes...
April 2016: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/26485774/-the-role-of-inherited-thrombophilia-and-undifferentiated-connective-tissue-dysplasia-syndrome-in-the-pathogenesis-of-female-infertility-a-clinical-and-morphological-study
#7
T A Demura, E A Kogan, A S Zanozin, D Yu Kolosovsky, N M Faizullina, E A Kalinina
UNLABELLED: Impaired endometrial receptivity is a major cause of reproductive losses in in vitro fertilization (IVF) cycles given a normal embryo. Its causes may be associated with many diseases, including inherited thrombophilia (IT) and undifferentiated connective tissue dysplasia syndrome (uCTDS). However, endometrial receptivity remains little studied. OBJECTIVE: to investigate the morphological and immunohistochemical substrates of impaired endometrial receptivity in women with uCTDS, IT, and their concurrence...
July 2015: Arkhiv Patologii
https://www.readbyqxmd.com/read/26436276/long-term-observations-of-nitrogen-and-phosphorus-export-in-paired-agricultural-watersheds-under-controlled-and-conventional-tile-drainage
#8
M D Sunohara, N Gottschall, G Wilkes, E Craiovan, E Topp, Z Que, O Seidou, S K Frey, D R Lapen
Controlled tile drainage (CTD) regulates water and nutrient export from tile drainage systems. Observations of the effects of CTD imposed en masse at watershed scales are needed to determine the effect on downstream receptors. A paired-watershed approach was used to evaluate the effect of field-to-field CTD at the watershed scale on fluxes and flow-weighted mean concentrations (FWMCs) of N and P during multiple growing seasons. One watershed (467-ha catchment area) was under CTD management (treatment [CTD] watershed); the other (250-ha catchment area) had freely draining or uncontrolled tile drainage (UCTD) (reference [UCTD] watershed)...
September 2015: Journal of Environmental Quality
https://www.readbyqxmd.com/read/26384526/interstitial-pneumonia-with-autoimmune-features-and-undifferentiated-connective-tissue-disease-our-interdisciplinary-rheumatology-pneumology-experience-and-review-of-the-literature
#9
REVIEW
Clodoveo Ferri, Andreina Manfredi, Marco Sebastiani, Michele Colaci, Dilia Giuggioli, Caterina Vacchi, Giovanni Della Casa, Stefania Cerri, Pietro Torricelli, Fabrizio Luppi
BACKGROUND: Interstitial lung diseases (ILDs) are a heterogeneous group of disorders characterized by inflammation and/or fibrosis of the lungs, varying from idiopathic interstitial pneumonias to secondary variants, including the ILDs associated to connective tissue diseases (CTDs). In addition, a number of patients are recognized as unclassifiable ILD (U-ILD), because of the inability to reach a definite diagnosis; some of them show autoimmune manifestations not fulfilling the classification criteria of a given CTD...
January 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/26338245/primary-thymic-extranodal-marginal-zone-b-cell-lymphoma-as-an-incidental-finding-in-a-caucasian-woman
#10
Jeanette Krogh Petersen, Thomas Stauffer Larsen, Michael Boe Møller, Claudia Stahlberg
Primary thymic extranodal marginal zone B cell lymphoma (TML) is an extremely rare lymphoma strongly associated with autoimmune disease. We report an exceedingly rare case of TML found in a non-Asian population. TML was found incidentally in a 60-year-old Caucasian woman with a short history of muscle and joint pain. An anterior mediastinal mass was detected by a positron emission tomography-CT (PET-CT) scan and thymectomy was performed. The mass was contained within the thymus with a homogeneous pale cut surface with solid areas...
2015: BMJ Case Reports
https://www.readbyqxmd.com/read/26206346/ultrasonography-of-major-salivary-glands-a-highly-specific-tool-for-distinguishing-primary-sj%C3%A3-gren-s-syndrome-from-undifferentiated-connective-tissue-diseases
#11
Nicoletta Luciano, Chiara Baldini, Gaia Tarantini, Ferro Ferro, Francesca Sernissi, Valentina Varanini, Valentina Donati, Daniela Martini, Marta Mosca, Davide Caramella, Stefano Bombardieri
OBJECTIVES: Recently, convincing data have been published on the value of salivary gland ultrasonography (SGUS) in differentiating primary SS from non-immune-mediated sicca syndrome. Limited data are available regarding the diagnostic accuracy of SGUS in distinguishing SS from other rheumatic diseases. The purpose of this study was to assess the usefulness of SGUS in distinguishing patients with SS from those with xerostomia and/or xerophthalmia and a diagnosis of stable UCTD. METHODS: This cross-sectional study consecutively enrolled 150 patients either diagnosed with SS (as established by the American-European Consensus Group criteria) or affected by UCTD but not SS...
December 2015: Rheumatology
https://www.readbyqxmd.com/read/25949407/fibrillary-glomerulonephritis-with-prevalent-iga-deposition-associated-with-undifferentiated-connective-tissue-disease-a-case-report
#12
Manuela Nebuloni, Augusto Genderini, Antonella Tosoni, Sabrina Caruso, Giovanni Barbiano di Belgiojoso
We described a 41-year-old female patient, who presented with proteinuria occurring 5 years after the onset of an undifferentiated connective tissue disease (UCTD). At renal biopsy, a pattern of focal necrotizing glomerulonephritis with mesangial and parietal deposition of the IgA, C3 and K chains was observed. Electron microscopy showed organized fibrillary deposits in mesangial, subendothelial, intramembranous and subepithelial sites. Fibrils were randomly arranged, had no hollow core and had a diameter ranging between 10 and 23 nm...
February 2010: NDT Plus
https://www.readbyqxmd.com/read/25922716/clinical-characteristics-and-survival-in-idiopathic-pulmonary-fibrosis-and-connective-tissue-disease-associated-usual-interstitial-pneumonia
#13
Esam H Alhamad
BACKGROUND: Previous studies have reported conflicting survival rates for connective tissue disease (CTD)-associated usual interstitial pneumonia (UIP) and idiopathic pulmonary fibrosis (IPF/UIP). This study investigated the differences in the clinical characteristics and prognoses of patients diagnosed with CTD-UIP and IPF/UIP. METHODS: A retrospective review of patients with IPF (n=88) and CTD-UIP (n=67) from January 2008 to June 2013 was completed. We compared the demographics and clinical characteristics between the two groups...
March 2015: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/25885224/anti-pm-scl-antibodies-are-found-in-japanese-patients-with-various-systemic-autoimmune-conditions-besides-myositis-and-scleroderma
#14
Yoshinao Muro, Yuji Hosono, Kazumitsu Sugiura, Yasushi Ogawa, Tsuneyo Mimori, Masashi Akiyama
INTRODUCTION: Anti-PM/Scl antibodies are associated with polymyositis (PM)/systemic scleroderma (SSc) overlap syndromes and are also found in other systemic autoimmune diseases. Although anti-PM/Scl reactivity is found in 3-11% of PM or SSc patients and in approximately 25% of PM/SSc overlap patients, previous large studies of Japanese patients with scleroderma reported that anti-PM/Scl are not found in Japanese patients at all. The PM/Scl autoantigen complex comprises 11-16 different polypeptides; ELISA with PM1-α peptide, which is a major epitope of the PM/Scl complex, has frequently been used for the detection of these antibodies in recent studies...
2015: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/25682542/broader-criteria-of-undifferentiated-connective-tissue-disease-in-idiopathic-interstitial-pneumonias
#15
COMPARATIVE STUDY
Yasuhiro Kondoh, Takeshi Johkoh, Junya Fukuoka, Hiroaki Arakawa, Tomonori Tanaka, Naohiro Watanabe, Koji Sakamoto, Kensuke Kataoka, Tomoki Kimura, Hiroyuki Taniguchi
BACKGROUND: Kinder et al. proposed a broader definition of undifferentiated connective tissue disease (UCTD) and reported that the entity of nonspecific interstitial pneumonia (NSIP) is a lung manifestation of this more broadly defined UCTD. However, a retrospective study did not support their findings and its clinical significance remains unclear. METHODS: We prospectively evaluated the significance of this broadly defined UCTD in idiopathic interstitial pneumonias (IIPs) in consecutive patients with surgical lung biopsy...
March 2015: Respiratory Medicine
https://www.readbyqxmd.com/read/25537566/nonspecific-interstitial-pneumonia-survival-is-influenced-by-the-underlying-cause
#16
Hilario Nunes, Kirsten Schubel, Diane Piver, Eline Magois, Séverine Feuillet, Yurdagul Uzunhan, Zohra Carton, Abdellatif Tazi, Pierre Levy, Pierre-Yves Brillet, Andrew G Nicholson, Marianne Kambouchner, Dominique Valeyre
Idiopathic, nonspecific interstitial pneumonia (NSIP) is most often associated with various clinical disorders, including connective tissue diseases (CTDs) and chronic hypersensitivity pneumonitis (cHP). Emerging evidence also suggests that "idiopathic" NSIP may be the lung manifestation of undifferentiated CTD (UCTD). However, whether or not NSIP outcome is influenced by the underlying cause remains uncertain. This retrospective study included 127 biopsy-proven NSIP patients (65 women, mean ± sd age 55 ± 12 years)...
March 2015: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/25334351/endogenous-lipoid-pneumonia-in-pulmonary-alveolar-proteinosis
#17
Adam Kaiser, Margaret Grimes, Kristin Miller
Miscellaneous Case Report Posters IISESSION TYPE: Affiliate Case Report PosterPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: Lipoid pneumonia (LP) is the filling of the airspace with lipid material with subsequent inflammation. We present a case of endogenous lipoid pneumonia (ELP) occurring in a man with pulmonary alveolar proteinosis (PAP).CASE PRESENTATION: A 46 year-old man with poorly controlled undifferentiated connective tissue disease (UCTD) despite therapy with methotrexate and biologic agents presented with hypoxic respiratory failure...
October 1, 2014: Chest
https://www.readbyqxmd.com/read/25274451/cytokine-milieu-in-undifferentiated-connective-tissue-disease-a-comprehensive-review
#18
REVIEW
Britt Nakken, Edit Bodolay, Peter Szodoray
Undifferentiated connective tissue disease (UCTD) is a unique clinical entity, a potential forerunner of well-established systemic autoimmune/rheumatic diseases. UCTD is characterized by the presence of various clinical symptoms, as well as a diverse repertoire of autoantibodies, resembling systemic autoimmune diseases. Since approximately one third of these patients consequently transform into a full-blown systemic autoimmune/rheumatic disease, it is of major importance to assess pathogenic factors leading to this progression...
October 2015: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/25211168/interstitial-pneumonia-related-to-undifferentiated-connective-tissue-disease-pathologic-pattern-and-prognosis
#19
Ho-Cheol Kim, Wonjun Ji, Mi Young Kim, Thomas V Colby, Se Jin Jang, Chang-Keun Lee, Seung Bong Han, Dong Soon Kim
BACKGROUND: Undifferentiated connective tissue disease (UCTD) involves conditions characterized by both having symptoms of connective tissue disease (CTD) and autoantibodies but not fulfilling the criteria of a specific CTD. The frequency or prognosis of the usual interstitial pneumonia (UIP) pattern in UCTD is unknown, which may be confused with idiopathic pulmonary fibrosis (IPF). This study aimed to investigate the frequency of the UIP pattern in interstitial pneumonia related to UCTD and compare its prognosis with that of IPF and UCTD-nonspecific interstitial pneumonia (UCTD-NSIP)...
January 2015: Chest
https://www.readbyqxmd.com/read/24917564/impaired-endothelial-function-in-patients-with-undifferentiated-connective-tissue-disease-a-follow-up-study
#20
Renata Laczik, Pal Soltesz, Peter Szodoray, Zoltan Szekanecz, Gyorgy Kerekes, Gyorgy Paragh, Eva Rajnavölgyi, Gyorgy Abel, Gyula Szegedi, Edit Bodolay
OBJECTIVE: In this study the alteration of endothelial function, arterial stiffness and autoantibodies was investigated in patients with UCTD. METHODS: Thirty-one patients with UCTD were included in this prospective study. All the patients remained in the UCTD stage during the average 3.8 years follow-up period. The onset of UCTD was denoted as UCTD1, while the end of the follow-up period was called UCTD2. Flow-mediated vasodilation (FMD), carotid intima-media thickness (IMT), autoantibodies [such as anti-SSA, anti-SSB, anti-DNA, anti-RNP, anti-CCP, aCL, anti-oxidized low-density lipoprotein (oxLDL) and AECA], von Willebrand factor antigen, thrombomodulin (TM), endothelin 1 (ET-1) and lipid parameters were measured...
November 2014: Rheumatology
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