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https://www.readbyqxmd.com/read/29786146/awareness-of-and-phobias-about-topical-corticosteroids-in-parents-of-infants-with-eczema-in-hangzhou-china
#1
Yunling Li, Ting Han, Wei Li, Yin Li, Xiaoxuan Guo, Lei Zheng
BACKGROUND/OBJECTIVES: Knowledge of and phobias about topical corticosteroids in parents of infants with eczema affect efficacy of eczema treatment. METHODS: We surveyed 300 parents of children with eczema using a questionnaire to investigate knowledge of and phobias about topical corticosteroids. RESULTS: Overall, 85.7% (n = 257) of children had used topical corticosteroids, with 12.8% (n = 33) of children having steroids applied for only 1-3 days per episode; 79...
May 22, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29782303/clindamycin-induced-maculopapular-exanthema-with-preferential-involvement-of-striae-distensae-a-koebner-phenomenon
#2
Benigno Monteagudo, Miguel Cabanillas, Pilar Iriarte, Aquilina Ramírez-Santos, Elvira León-Muinos, Daniel González-Vilas, Óscar Suárez-Amor
Clindamycin is a lincomycin-derived antibiotic useful for the treatment of anaerobic and Gram-positive aerobic bacterial infections. Cutaneous adverse reactions are usually maculopapular exanthemas, although hypersensitivity syndrome, acute generalized exanthematous pustulosis, and Stevens-Johnson syndrome have also been reported (1). We report the case of a patient with a maculopapular rash triggered by clindamycin who developed cutaneous lesions on striae distensae (SD). A 47-year-old woman was referred to our clinic for pruritic cutaneous lesions which had started 6 days earlier...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29763411/characteristics-and-health-care-resource-use-of-subjects-with-copd-in-the-year-before-initiating-lama-monotherapy-or-lama-laba-combination-therapy-a-u-s-database-study
#3
Saurabh Nagar, Jeetvan Patel, Richard H Stanford
PURPOSE: To characterize subjects with chronic obstructive pulmonary disease (COPD) newly initiated on long-acting muscarinic antagonists (LAMA) or dual LAMA/long-acting β2-adrenergic agonist (LABA) therapy. DESIGN: This pilot/preliminary analysis was a retrospective crosssectional study of subjects with COPD from the Optum Impact National Managed Care Benchmark Database. METHODOLOGY: Subjects with at least one LAMA prescription in the index period (July 2008-June 2009) were included and stratified by treatment...
May 2018: Managed Care
https://www.readbyqxmd.com/read/29762208/prevalence-of-atopic-dermatitis-and-pattern-of-drug-therapy-in-malaysian-children
#4
Yi-Yeong Goh, Fazlollah Keshavarzi, Yik Ling Chew
BACKGROUND: Atopic dermatitis (AD) is a chronic relapsing, noncontagious skin inflammation characterized by dry skin and itch. Mutation in filaggrin gene leads to defective skin barrier, allowing entry of allergen and eliciting immunological response. OBJECTIVES: The aims of this study were to investigate the prevalence of AD in Malaysian children and to understand the pattern of drug therapy. Such information could be useful to establish the relationship between ethnicity and family history of atopy and the development of associated signs and symptoms...
May 2018: Dermatitis
https://www.readbyqxmd.com/read/29743896/investigating-the-effectiveness-of-the-trigonella-foenum-graecum-l-fenugreek-seeds-in-mild-asthma-a-randomized-controlled-trial
#5
Majid Emtiazy, Laleh Oveidzadeh, Minoo Habibi, Leila Molaeipour, Daryush Talei, Zahra Jafari, Mahmoud Parvin, Mohammad Kamalinejad
Background: Asthma is one of the important chronic diseases. The asthma prevalence is increasing in last decades. Despite the presence of good controller drugs like corticosteroids, about 60% of asthmatic patients use alternative medicine. This study was done to determine the effectiveness of Tregonella foenum graceum (fenugreek) seeds in mild asthma. Methods: It is a double blind trial with placebo effect. One of the ancient prescriptions from Persian Medicine was selected...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29741439/healthcare-resource-use-and-cost-associated-with-varying-dosages-of-extended-corticosteroid-exposure-in-a-us-population
#6
J Bradford Rice, Alan G White, Michaela Johnson, Aneesha Wagh, Yimin Qin, Laura Bartels-Peculis, Gosia Ciepielewska, Winnie W Nelson
AIMS: Quantify healthcare resource use (HCRU) and costs associated with varying levels of corticosteroid exposure. MATERIALS AND METHODS: Patients with a diagnosis of selected autoimmune and inflammatory diseases between 1/1/2006 and 9/30/2015 ("study period") were selected from a de-identified, privately-insured claims database. Patients were stratified into four treatment cohorts based on the dosing and duration of continuous corticosteroid use following disease diagnosis: intermittent use with <60 days of corticosteroid use and ≥60 days of corticosteroid use with low (≤7...
May 9, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29731926/practical-approach-to-lung-health-experience-from-the-republic-of-macedonia
#7
Biljana Ilievska-Poposka, Maja Zakoska, Stefan Talevski
BACKGROUND: Among the adults and children aged 5 yrs who attend PHC settings, 20-30% seeks to care for respiratory symptoms. Over 80-90% of the respiratory patients suffer from acute respiratory infections (ARI), followed by chronic obstructive pulmonary diseases (COPD), asthma, and less frequently with pneumonia and tuberculosis (TB). To improve the quality of care in patients who seek assistance for respiratory symptoms in PHC settings and the efficiency of respiratory service delivery within healthcare systems, WHO has designated several initiatives among which one is PAL (Practical Approach to Lung Health)...
April 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29724210/drug-use-in-the-management-of-uncomplicated-malaria-in-public-health-facilities-in-the-democratic-republic-of-the-congo
#8
Nsengi Y Ntamabyaliro, Christian Burri, Didier B Nzolo, Aline B Engo, Yves N Lula, Samuel M Mampunza, Célestin N Nsibu, Gauthier K Mesia, Jean-Marie N Kayembe, Joris L Likwela, Leon M Kintaudi, Gaston L Tona
BACKGROUND: Malaria the first causes of death from parasitic infection worldwide. Interventions to reduce the burden of malaria have produced a tremendous drop in malaria morbidity and mortality. However, progress is slower in DRC, which shares with Nigeria 39% of deaths related to malaria globally. Inappropriate use of drugs may be one of the factors of this below-average performance. The aim of this study was to describe the use of drugs in the management of uncomplicated malaria in public health facilities in DRC...
May 3, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29724175/risk-and-impact-of-herpes-zoster-among-copd-patients-a-population-based-study-2009-2014
#9
Cintia Muñoz-Quiles, Mónica López-Lacort, Javier Díez-Domingo
BACKGROUND: The objective of this study was to assess the incidence of Herpes Zoster (HZ) among patients with chronic obstructive pulmonary disease (COPD) and the impact of HZ on the underlying COPD. METHODS: A retrospective cohort of all subjects older than 49 years was followed up between 2009 and 2014 using population and health databases of Valencia Region (Spain). HZ and COPD were identified using ICD-9 codes, differentiating COPD patients with inhaled corticosteroids prescriptions (COPD-ICS)...
May 3, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29713354/severe-eosinophilic-asthma-in-primary-care-in-canada-a-longitudinal-study-of-the-clinical-burden-and-economic-impact-based-on-linked-electronic-medical-record-data
#10
Don Husereau, Jason Goodfield, Richard Leigh, Richard Borrelli, Michel Cloutier, Alain Gendron
Background: Stratification of patients with severe asthma by blood eosinophil counts predicts responders to anti-interleukin (IL)-5 (mepolizumab and reslizumab) and anti-IL-5 receptor α (benralizumab) therapies. This study characterized patients with severe asthma who could qualify for these biologics in a primary care setting. Methods: We retrospectively selected patients from July 1, 2010, to June 30, 2014, using a linked electronic medical records (EMR) database (IMS Evidence 360 EMR Canada) for > 950,000 patients in primary care in Ontario, Canada...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29706103/topical-treatment-utilization-for-patients-with-atopic-dermatitis-in-the-united-states-and-budget-impact-analysis-of-crisaborole-ointment-2
#11
Ryan Clark, Duygu Bozkaya, Mark Levenberg, Steven Faulkner, Timothy W Smith, Robert A Gerber
BACKGROUND: Atopic dermatitis (AD), a chronic inflammatory skin disease, is often treated with topical corticosteroids (TCS) and topical calcineurin inhibitors (TCI). Crisaborole ointment is a nonsteroidal, phosphodiesterase 4 inhibitor for the treatment of mild to moderate AD. In December 2016, crisaborole was approved in the US for mild to moderate AD in patients ≥2 years of age. AIMS: To evaluate real-world utilization and cost of TCS and TCI in the US and estimate the budget impact of crisaborole over 2-years from a third-party payer perspective...
April 30, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29706020/the-effects-of-season-and-weather-on-healthcare-utilization-among-patients-with-atopic-dermatitis
#12
Carsten R Hamann, Yuki M F Andersen, Kristiane A Engebretsen, Lone Skov, Jonathan I Silverberg, Alexander Egeberg, Jacob P Thyssen
BACKGROUND: Patient reported triggers for atopic dermatitis (AD) flares include changes in ultraviolet irradiation, humidity and temperature. OBJECTIVES: To identify the relationships between weather data and healthcare utilization in AD patients. METHODS: Using nationwide healthcare registries, clinic (1994-2012) and hospital visits (1977-2012) for AD treatment were calculated as well as monthly totals of topical corticosteroid (TCS) (1996-2012) and calcineurin inhibitor (TCI) prescriptions (2003-20012) filled by AD patients...
April 28, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29694289/economic-burden-associated-with-receiving-inhaled-corticosteroids-with-leukotriene-receptor-antagonists-or-long-acting-beta-agonists-as-combination-therapy-in-older-adults
#13
Shoroq M Altawalbeh, Carolyn T Thorpe, Janice C Zgibor, Sandra Kane-Gill, Yihuang Kang, Joshua M Thorpe
BACKGROUND: There is a paucity of literature on the health care expenditures associated with different pharmacologic treatments in older adults with asthma that is not well controlled on inhaled corticosteroids (ICS). OBJECTIVE: To compare asthma-related and all-cause health care expenditures associated with leukotriene receptor antagonists (LTRA) versus long-acting beta agonists (LABA) when added to ICS in older adults with asthma. METHODS: A retrospective cohort was constructed using 2009-2010 Medicare fee-for-service medical and pharmacy claims from a 10% random sample of beneficiaries continuously enrolled in Parts A, B, and D in 2009...
May 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29694287/one-year-outcomes-of-an-integrated-multiple-sclerosis-disease-management-program
#14
Marti Groeneweg, Sara H Forrester, Beth Arnold, Lorella Palazzo, Weiwei Zhu, Paul Yoon, Tim Scearce
BACKGROUND: Multiple sclerosis (MS) is associated with high total health care cost, the majority of which is attributable to medications. Patients with MS are less likely to experience relapses, emergency department (ED) visits, and hospitalizations when they are adherent to disease-modifying treatments. Disease management programs are hypothesized to improve medication adherence thereby improving clinical and economic outcomes. OBJECTIVE: To evaluate the clinical and economic effects of a specialty pharmacy and chronic disease management program for patients with MS from a health plan perspective...
May 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29682493/the-frequency-of-clinic-visits-was-not-associated-with-medication-adherence-or-outcome-in-children-with-inflammatory-bowel-diseases
#15
Cheryl Kluthe, Jenkin Tsui, Donald Spady, Matthew Carroll, Eytan Wine, Hien Quoc Huynh
Background: Medication nonadherence is a challenge in pediatric patients with inflammatory bowel diseases (IBD). Poor adherence can result in disease flare-ups, disease complicationstherapy escalation, and the need for corticosteroids. The aim was to determine if clinic visit frequency was associated with treatment adherence. Methods: A retrospective chart review of patients attending the Edmonton Pediatric IBD Clinic (EPIC) at the Stollery Children's Hospital from January 2012 to December 2013 was completed...
2018: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29668982/improved-medical-treatment-and-surgical-surveillance-of-children-and-adolescents-with-ulcerative-colitis-in-the-united-kingdom
#16
Marcus Karl-Keinz Auth, Su K Bunn, Aimee Leanne Protheroe, Linda Jane Williams, John M Fell, Rafeeq Muhammed, Nicholas Michael Croft, R Mark Beattie, Anne Willmott, Christine Spray, Babu Vadamalayan, Astor Rodrigues, John Puntis, Anna Jane Pigott, David C Wilson, Sally Mitton, Mark Furman, Charlie Charlton, Sonny K F Chong, Richard K Russell
Background: Pediatric ulcerative colitis (UC) presents at an earlier age and increasing prevalence. Our aim was to examine morbidity, steroid sparing strategies, and surgical outcome in children with active UC. Methods: A national prospective audit was conducted for the inpatient period of all children with UC for medical or surgical treatment in the United Kingdom (UK) over 1 year. Thirty-two participating centers recruited 224 children in 298 admissions, comparisons over 6 years were made with previous audits...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29667330/no-increased-risk-of-herpes-zoster-in-tnf-inhibitor-and-non-tnf-inhibitor-users-with-rheumatoid-arthritis-epidemiological-study-using-the-japanese-health-insurance-database
#17
Ryoko Sakai, Shoko Kasai, Fumio Hirano, Sayoko Harada, Mari Kihara, Waka Yokoyama, Michi Tsutsumino, Kenji Nagasaka, Ryuji Koike, Hisashi Yamanaka, Nobuyuki Miyasaka, Masayoshi Harigai
OBJECTIVE: It is controversial whether the use of biological disease-modifying antirheumatic drugs (DMARDs) increases the risk of herpes zoster (HZ). We aimed to evaluate the risks of HZ in tumor necrosis factor inhibitor (TNFI) and non-TNFI users with rheumatoid arthritis (RA) over 3 years in Japan. METHOD: Using the Japanese health insurance database, we assigned patients with at least one RA diagnostic code and one prescription for any DMARDs (RA cases) recorded between January 2005 and December 2013 to the RA group...
April 17, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29663966/access-to-asthma-medicines-at-the-household-level-in-eight-counties-of-kenya
#18
D Barakat, P C Rockers, T Vian, M A Onyango, R O Laing, V J Wirtz
BACKGROUND: It is estimated that about 4 million Kenyans, i.e., 10% of the country's population, have asthma. We aimed to evaluate access to asthma medicines at the household level in eight counties of Kenya, including factors associated with location of purchase. METHODS: Individuals with a diagnosis and prescription of asthma medicines were asked about the location of diagnosis, purchase of medicines, availability of medicines at home and costs of medicines per month...
May 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29662064/the-use-of-electronic-alerts-in-primary-care-computer-systems-to-identify-the-excessive-prescription-of-short-acting-beta-2-agonists-for-people-with-asthma-a-systematic-review
#19
REVIEW
Shauna McKibben, Anna De Simoni, Andy Bush, Mike Thomas, Chris Griffiths
Computers are increasingly used to improve prescribing decisions in the management of long-term conditions however the effects on asthma prescribing remain unclear. We aimed to synthesise the evidence for the use of computerised alerts that identify excessive prescribing of short-acting beta2 -agonists (SABAs) to improve asthma management for people with asthma. MEDLINE, CINAHL, Embase, Cochrane and Scopus databases (1990-2016) were searched for randomised controlled trials using electronic alerts to identify excessive prescribing of SABAs for people with asthma in primary care...
April 16, 2018: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/29642882/assessing-the-healthcare-resource-use-associated-with-inappropriate-prescribing-of-inhaled-corticosteroids-for-people-with-chronic-obstructive-pulmonary-disease-copd-in-gold-groups-a-or-b-an-observational-study-using-the-clinical-practice-research-datalink
#20
James D Chalmers, Chris Poole, Samantha Webster, Abigail Tebboth, Scott Dickinson, Alicia Gayle
BACKGROUND: Recent recommendations from the Global Initiative for Chronic Obstructive Lung Disease (GOLD) position inhaled corticosteroids (ICS) for use in chronic obstructive pulmonary disease (COPD) patients experiencing exacerbations (≥ 2 or ≥ 1 requiring hospitalisation); i.e. GOLD groups C and D. However, it is known that ICS is frequently prescribed for patients with less severe COPD. Potential drivers of inappropriate ICS use may be historical clinical guidance or a belief among physicians that intervening early with ICS would improve outcomes and reduce resource use...
April 11, 2018: Respiratory Research
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