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nasopharygeal carcinoma

Xiqing Li, Zhunlan Zhao, Xiaoling Zhang, Sheng Yang, Xia Lin, Xinglong Yang, Xiaolin Lin, Junwen Shi, Shengchun Wang, Wentao Zhao, Jing Li, Fei Gao, Mingyue Liu, Ning Ma, Weiren Luo, Kaitai Yao, Yan Sun, Shengjun Xiao, Dong Xiao, Junshuang Jia
The reprogramming factor Krüppel-like factor 4 (Klf4), one of the Yamanaka's reprogramming factors, plays an essential role in reprogramming somatic cells into induced pluripotent stem cells (iPSCs). Klf4 is dysregulated and displays divergent functions in multiple malignancies, but the biological roles of Klf4 in nasopharyngeal carcinoma (NPC) remain unknown. The present study revealed that Klf4 downregulation in a cohort of human NPC biopsies is significantly associated with invasive and metastatic phenotypes of NPC...
November 7, 2017: Oncotarget
Ting Bi, Feng Jin, Weili Wu, Jinhua Long, Yuanyuan Li, Xiuyun Gong, Xiuling Luo, Zhuoling Li, Qianyong He, Bo Qu
OBJECTIVE: To compare the therapeutic effects, toxic side effects and influence on the immune function in patients treated with TPF [docetaxel (DOC) + cisplatin (DDP) + 5-fluorouracil (5-Fu)] induction chronochemotherapy and conventional chemotherapy for locally advanced nasopharyngeal (NPC). METHODS: Seventy patients with locally advanced nasopharyngeal carcinoma were treated in our department at their first visit from April 2013 to December 2013. They were divided randomly into two groups: the chronochemotherapy group (38 patients) and conventional chemotherapy group (32 patients)...
September 2015: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
Yuan-Xue Jiang, Zi-Ming Du, Lin Jiao, Qiong Shao, Sha Fu, Jian-Yong Shao, Xiao-Feng Zhu, Ingemar Ernberg, Yu-Hong Li
Overexpression of miR-155 in nasopharygeal carcinoma (NPC) is partly driven by Epstein-Bar virus infection. However the role of miR-155 in NPC oncogenesis is unclear. This study showed that miR-155 inhibitor could inhibit the cell migration in NPC cell lines. ZDHHC2 was identified as a direct target of miR-155 and downregulation of ZDHHC2 prompted cell migration in NPC. Furthermore, reduced ZDHHC2 expression was associated significantly with metastasis and poor survival of NPC patients. Collectively, inhibition of miR-155 suppresses cell migration in NPC through targeting ZDHHC2...
2015: International Journal of Clinical and Experimental Medicine
Tao Chen, Biaoli Long, Guosheng Ren, Tingxiu Xiang, Lili Li, Zhaohui Wang, Ya He, Quan Zeng, Suling Hong, Guohua Hu
Genetic alterations of 13q21 (PCDH 8,9,17, and 20) are frequently observed in multiple tumors, suggesting the presence of critical tumor suppressor genes (TSGs). Protocadherin20 (PCDH20), located at 13q21.2, belongs to the δ1-protocadherins, which constitutes one of the largest subgroup within the adherin superfamily. Frequent downregulation/silencing of PCDH20 was found in NPC cell lines using semiquantitative PCR. PCDH20 mRNA was broadly expressed in normal nasopharyngeal tissues and cell lines. Promoter methylation of PCDH20 was observed in 80% (4/5) of NPC cell lines and 78...
August 2015: Journal of Cellular Biochemistry
Miao Yun, Hai-Yan Bai, Jia-Xing Zhang, Jian Rong, Hui-Wen Weng, Zhou-San Zheng, Yi Xu, Zhu-Ting Tong, Xiao-Xia Huang, Yi-Ji Liao, Shi-Juan Mai, Sheng Ye, Dan Xie
Plenty of studies have established that dysregulation of autophagy plays an essential role in cancer progression. The autophagy-related proteins have been reported to be closely associated with human cancer patients' prognosis. We explored the expression dynamics and prognostic value of autophagy-related protein ULK1 by immunochemistry (IHC) method in two independent cohorts of nasopharygeal carcinoma (NPC) cases. The X-tile program was applied to determine the optimal cut-off value in the training cohort. This derived cutoff value was then subjected to analysis the association of ULK1 expression with patients' clinical characteristics and survival outcome in the validation cohort and overall cases...
2015: PloS One
Ricard Mesía, Michael Henke, Andre Fortin, Heikki Minn, Alejandro Cesar Yunes Ancona, Anthony Cmelak, Avi B Markowitz, Sebastien J Hotte, Simron Singh, Anthony T C Chan, Marco C Merlano, Krzysztof Skladowski, Alicia Zhang, Kelly S Oliner, Ari VanderWalde, Jordi Giralt
BACKGROUND: Panitumumab is a fully human monoclonal antibody that targets EGFR. We aimed to compare chemoradiotherapy plus panitumumab with chemoradiotherapy alone in patients with unresected, locally advanced squamous-cell carcinoma of the head and neck. METHODS: In this international, open-label, randomised, controlled, phase 2 trial, we recruited patients with locally advanced squamous-cell carcinoma of the head and neck from 41 sites in nine countries worldwide...
February 2015: Lancet Oncology
Jordi Giralt, Jose Trigo, Sandra Nuyts, Mahmut Ozsahin, Krzysztof Skladowski, Georges Hatoum, Jean-Francois Daisne, Alejandro César Yunes Ancona, Anthony Cmelak, Ricard Mesía, Alicia Zhang, Kelly S Oliner, Ari VanderWalde
BACKGROUND: We aimed to compare panitumumab, a fully human monoclonal antibody against EGFR, plus radiotherapy with chemoradiotherapy in patients with unresected, locally advanced squamous-cell carcinoma of the head and neck. METHODS: In this international, open-label, randomised, controlled, phase 2 trial, we recruited patients with locally advanced squamous-cell carcinoma of the head and neck from 22 sites in eight countries worldwide. Patients aged 18 years and older with stage III, IVa, or IVb, previously untreated, measurable (≥ 10 mm for at least one dimension), locally advanced squamous-cell carcinoma of the head and neck (non-nasopharygeal) and an Eastern Cooperative Oncology Group performance status of 0-1 were randomly assigned (2:3) by an independent vendor to open-label chemoradiotherapy (two cycles of cisplatin 100 mg/m(2) during radiotherapy) or to radiotherapy plus panitumumab (three cycles of panitumumab 9 mg/kg every 3 weeks administered with radiotherapy) using a stratified randomisation with a block size of five...
February 2015: Lancet Oncology
Liming Jiang, Haimiao Xu, Jun Lin, Lirong Tang, Tiemin Xie, Xing Yan, Hao Jiang
OBJECTIVE: The aim was to evaluate the effectiveness of computed tomography (CT)-guided fine-needle aspiration biopsy (FNAB) from Mandibular notch and under the zygomatic arch for pathological diagnosis of recurrence nasopharyngeal carcinoma (NPC) after radiotherapy (RT). MATERIALS AND METHODS: Between October 2007 and December 2013, 48 patients with suspected recurrent NPC underwent CT-guided FNAB. A modified coaxial technique was used in all cases, and multiple samples were obtained for histological studies...
November 2014: Journal of Cancer Research and Therapeutics
Pin-Zhir Chao, Ming-Shium Hsieh, Chao-Wen Cheng, Tin-Jui Hsu, Yun-Tien Lin, Chang-Hao Lai, Chen-Chung Liao, Wei-Yu Chen, Ting-Kai Leung, Fei-Peng Lee, Yung-Feng Lin, Chien-Ho Chen
Dendritic cells (DCs) play an essential role in immunity and are used in cancer immunotherapy. However, these cells can be tuned by tumors with immunosuppressive responses. DC-specific intercellular adhesion molecule 3-Grabbing Nonintegrin (DC-SIGN), a C-type lectin expressed on DCs, recognizes certain carbohydrate structures which can be found on cancer cells. Nasopharyngeal carcinoma (NPC) is an epithelial cell-derived malignant tumor, in which immune response remains unclear. This research is to reveal the molecular link on NPC cells that induces the immunosuppressive responses in DCs...
January 1, 2015: Oncotarget
Yi-Ting Lin, Chia-Chun Huang, Charng-Cherng Chyau, Kuan-Chou Chen, Robert Y Peng
BACKGROUND: The hypothalamic-pituitary (h-p) unit is a particularly radiosensitive region in the central nervous system. As a consequence, radiation-induced irreversible, progressively chronic onset hypopituitarism (RIH) commonly develops after radiation treatments and can result in variably impaired pituitary function, which is frequently associated with increased morbidity and mortality. CASE PRESENTATION: A 38-year-old male subject, previously having received radiotherapy for treatment of nasopharygeal carcinoma (NPCA) 16 years ago, appeared at OPD complaining about his failure in penile erection, loss of pubic hair, atrophy of external genitalia: testicles reduced to 2×1...
2014: BMC Urology
Ching-Chan Lin, Tzu-Ting Chen, Chen-Yuan Lin, Ching-Yun Hsieh, Po-Han Lin, Chun-Ru Chien, Chang-Fang Chiu, Su-Peng Yeh
BACKGROUND: Concurrent chemoradiation has become the standard of treatment in locally advanced nasopharyngeal carcinoma. However, the exact magnitude of the benefits of adjuvant chemotherapy is still unclear. MATERIALS & METHODS: This is a retrospective assessment of 181 patients with newly diagnosed, locally advanced nasopharygeal carcinoma who received concurrent chemoradiation followed by adjuvant chemotherapy with cisplatin plus fluorouracil in one institution between 2004 and 2010...
October 2013: Future Oncology
Elizabeth Calderón Alicea, Mónica Santiago-Casiano, William Cáceres-Perkins, Alvin Almodovar
A 64 year-old Hispanic male patient presented to our institution with a three-month history of frontal headaches, reduced vision, retroorbital pain, photophobia, sinus congestion, bloody nasal discharge, and decreased audition in the left ear. The diagnosis of metastatic lymphoepithelioma to the orbit was made based on clinical history, histopathological examination of an orbital biopsy, and imaging studies. Lymphoepithelioma rarely develops in Hispanic populations. However, it is endemic in certain areas, including North Africa, Southeast Asia...
September 2012: Boletín de la Asociación Médica de Puerto Rico
Cai-neng Cao, Jing-wei Luo, Li Gao, Jun-lin Yi, Xiao-dong Huang, Kai Wang, Shi-ping Zhang, Yuan Qu, Su-yan Li, Wei-ming Cai, Jian-ping Xiao, Zhong Zhang, Guo-zhen Xu
OBJECTIVE: To discuss the clinical characteristics and patterns of failure in the parotid region after intensity-modulated radiotherapy for nasopharygeal carcinoma. MATERIALS AND METHODS: We retrospectively reviewed the charts of 716 patients with nasopharygeal carcinoma who underwent intensity-modulated radiotherapy in our centre from January 2005 to December 2010. Disease recurred in a spared parotid gland in 10 patients (1.4%). There were 2 females and 8 males with a median age of 38...
June 2013: Oral Oncology
Monica W K Kan, Lucullus H T Leung, Ronald W K So, Peter K N Yu
PURPOSE: To compare the doses calculated by the Acuros XB (AXB) algorithm and analytical anisotropic algorithm (AAA) with experimentally measured data adjacent to and within heterogeneous medium using intensity modulated radiation therapy (IMRT) and RapidArc(®) (RA) volumetric arc therapy plans for nasopharygeal carcinoma (NPC). METHODS: Two-dimensional dose distribution immediately adjacent to both air and bone inserts of a rectangular tissue equivalent phantom irradiated using IMRT and RA plans for NPC cases were measured with GafChromic(®) EBT3 films...
March 2013: Medical Physics
Ladan Saleh-Ebrahimi, Felix Zwicker, Marc W Muenter, Marc Bischof, Katja Lindel, Juergen Debus, Peter E Huber, Falk Roeder
BACKGROUND: We report our experience in 49 consecutive patients with nasopharyngeal carcinoma who were treated by Intensity-modulated radiation therapy (IMRT) combined with simultaneous but not adjuvant chemotherapy (CHT). METHODS: The medical records of 49 patients with histologically proven primary nasopharygeal carcinoma treated with IMRT and concurrent platin-based CHT (predominantly cisplatin weekly) were retrospectively reviewed. The majority of patients showed advanced clinical stages (stage III/IV:72%) with undifferentiated histology (82%)...
2013: Radiation Oncology
Kok-Siong Yeo, Taznim Begam Mohd Mohidin, Ching-Ching Ng
Epstein-Barr virus (EBV) is a ubiquitous tumor-causing virus which infects more than 90% of the world population asymptomatically. Recent studies suggest that LMP-1, -2A and -2B cooperate in the tumorigenesis of EBV-associated epithelial cancers such as nasopharygeal carcinoma, oral and gastric cancer. In this study, LMPs were expressed in the HEK293T cell line to reveal their oncogenic mechanism via investigation on their involvement in the regulation of the cell cycle and genes that are involved. LMPs were expressed in HEK293T in single and co-expression manner...
December 2012: Comptes Rendus Biologies
Eugene Yu, Fred Gentili, Eric Bartlett, Patrick Gullane, Tim-Rasmus Kiehl
No abstract text is available yet for this article.
August 2012: Journal of Otolaryngology—Head & Neck Surgery
Rui Wei, Ding-yi Yang, Wu-zhong Jiang, You-yi Dai, Long-yun Wan, Zhen Yang
OBJECTIVE: To evaluate the efficacy and toxicity of Yanshu injection (a compound Chinese traditional medicine from Sophora flauescens Ait) combined with concomitant radiochemotherapy in patients with stage III nasopharyngeal carcinoma. METHODS: Sixty patients with stage III nasopharyngeal carcinoma were randomized into Yanshu group and control group (n = 30, each). Patients in the Yanshu group received Yanshu injection in addition to intensity modulated radiation therapy (IMRT) and concomitant chemotherapy, and those in the control group were treated with IMRT and concurrent chemotherapy...
May 2011: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
Falk Roeder, Felix Zwicker, Ladan Saleh-Ebrahimi, Carmen Timke, Christian Thieke, Marc Bischof, Juergen Debus, Peter E Huber
PURPOSE: To report our experience with intensity-modulated or stereotactic reirradiation in patients suffering from recurrent nasopharyngeal carcinoma PATIENTS AND METHODS: The records of 17 patients with recurrent nasopharygeal carcinoma treated by intensity-modulated (n = 14) or stereotactic (n = 3) reirradiation in our institution were reviewed. Median age was 53 years and most patients (n = 14) were male. The majority of tumors showed undifferentiated histology (n = 14) and infiltration of intracranial structures (n = 12)...
2011: Radiation Oncology
Sheng-Fa Su, Fei Han, Chong Zhao, Chun-Yan Chen, Wei-Wei Xiao, Jia-Xin Li, Tai-Xiang Lu
PURPOSE: Reports of intensity-modulated radiotherapy (IMRT) for early-stage nasopharyngeal carcinoma (NPC) have been limited. The present study evaluated the long-term survival outcomes and toxicity of early-stage NPC patients treated with IMRT alone. METHODS AND MATERIALS: Between February 2001 and January 2008, 198 early-stage (T1-T2bN0-N1M0) NPC patients had undergone IMRT alone. The data from these patients were retrospectively analyzed. The patients were treated to 68 Gy at 2...
January 1, 2012: International Journal of Radiation Oncology, Biology, Physics
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