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https://www.readbyqxmd.com/read/29223110/systemic-inflammatory-markers-associated-with-cardiovascular-disease-and-acute-and-chronic-exposure-to-fine-particulate-matter-air-pollution-pm2-5-among-us-nhanes-adults-with-metabolic-syndrome
#1
Arvind Dabass, Evelyn O Talbott, Judith R Rager, Gary M Marsh, Arvind Venkat, Fernando Holguin, Ravi K Sharma
BACKGROUND: There has been no investigation to date of adults with metabolic syndrome examining the association of short and long-term exposure to fine particulate matter (PM2.5) air pollution with cardiovascular-disease related inflammatory marker (WBC and CRP) levels in a nationally representative sample. The goal of this study is to assess the susceptibility of adults with metabolic syndrome to PM2.5 exposure as suggested by increased cardiovascular-disease related inflammatory marker levels...
December 6, 2017: Environmental Research
https://www.readbyqxmd.com/read/29222836/biochemical-and-structural-insights-into-a-thermostable-cellobiohydrolase-from-myceliophthora-thermophila
#2
Marco Antonio Seiki Kadowaki, Paula Higasi, Mariana Ortiz de Godoy, Rolf A Prade, Igor Polikarpov
Cellobiohydrolases hydrolyze cellulose, a linear polymer with glucose monomers linked exclusively by β-1,4 glycosidic linkages. The widespread hydrogen bonding network tethers individual cellulose polymers forming crystalline cellulose, which prevent the access of hydrolytic enzymes and water molecules. The most abundant enzyme secreted by Myceliophthora thermophila M77 in response to the presence of biomass is the cellobiohydrolase MtCel7A, which is composed by a GH7-catalytic domain (CD), a linker and a CBM1-type carbohydrate binding module...
December 8, 2017: FEBS Journal
https://www.readbyqxmd.com/read/29222636/identification-introgression-and-molecular-marker-genetic-analysis-and-selection-of-a-highly-effective-novel-oat-crown-rust-resistance-from-diploid-oat-avena-strigosa
#3
Howard W Rines, Marisa E Miller, Martin Carson, Shiaoman Chao, Tyler Tiede, Jochum Wiersma, Shahryar F Kianian
Oat crown rust is one of the most damaging diseases of oat. We identified a new source of resistance and developed KASP and TaqMan markers for selection in breeding programs. A new highly effective resistance to oat crown rust (Puccinia coronata f. sp. avenae) was identified in the diploid oat Avena strigosa PI 258731 and introgressed into hexaploid cultivated oat. Young plants with this resistance show moderate susceptibility, whereas older plant tissues and adult plants are resistant with no virulent isolates encountered in over 8 years of testing...
December 6, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/29222496/genome-wide-and-gene-based-association-mapping-for-rice-eating-and-cooking-characteristics-and-protein-content
#4
Xiaoqian Wang, Yunlong Pang, Jian Zhang, Zhichao Wu, Kai Chen, Jauhar Ali, Guoyou Ye, Jianlong Xu, Zhikang Li
Rice eating and cooking quality and protein content (PC) are important properties affecting consumers' preferences, nutrition and health. Linkage QTL mapping and association studies are usually applied to genetically dissect related traits, which could be further facilitated by high density SNP markers and gene annotation based on reference genome to rapid identify candidate genes associated with interested traits. Here, we carried out an association study for apparent amylose content (AC), gel consistency (GC), gelatinization temperature (GT) and PC evaluated in two environments using a diverse panel of 258 accessions from 3 K Rice Genome Project...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29221994/allele-and-haplotype-diversity-of-12-x-strs-in-sardinia
#5
C Robino, D Lacerenza, S Aneli, C Di Gaetano, G Matullo, R Robledo, C Calò
The analysis of clusters of tightly linked X-chromosome short tandem repeat (STR) markers can assist the interpretation of complex kinship cases. However, when linkage disequilibrium (LD) is present in the population of origin of tested individuals, haplotype rather than allele frequencies should be used in likelihood calculations. The diversity of twelve X-STRs arranged in four linkage groups (I: DXS10148-DXS10135-DXS8378; II: DXS7132-DXS10079-DXS10074; III: DXS10103-HPRTB-DXS10101; IV: DXS10146-DXS10134-DXS7423) was tested in a Sardinian population sample (n=516) including three open populations from the Northern, Central and Southern part of the island, and three isolates (Benetutti, Desulo, Carloforte)...
December 5, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/29221736/differential-effects-of-operative-complications-on-survival-after-surgery-for-primary-lung-cancer
#6
Felix G Fernandez, Andrzej S Kosinski, Anthony P Furnary, Mark Onaitis, Sunghee Kim, Robert H Habib, Betty C Tong, Patricia Cowper, Daniel Boffa, Jeffrey P Jacobs, Cameron D Wright, Joe B Putnam
OBJECTIVE: Complications adversely affect survival after lung cancer surgery. We tested the hypothesis that effects of complications after lung cancer surgery on survival vary substantially across the spectrum of postoperative complications. METHODS: The Society of Thoracic Surgeons General Thoracic Surgery Database was linked to Medicare data for lung cancer resections from 2002 through 2013. Linkage was achieved for 29,899 patients. A survival model was created that included operative complications as explanatory variables and adjusted for relevant baseline covariates...
November 13, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29221136/kif3a-and-il-4-are-disease-specific-biomarkers-for-psoriatic-arthritis-susceptibility
#7
Raffaella Cascella, Claudia Strafella, Michele Ragazzo, Laura Manzo, Gaetana Costanza, John Bowes, Ulrike Hüffmeier, Saverio Potenza, Federica Sangiuolo, André Reis, Anne Barton, Giuseppe Novelli, Augusto Orlandi, Emiliano Giardina
To date, the genes associated with Psoriatic Arthritis (PsA) are principally involved in inflammation, immune response and epidermal differentiation, without any information about the relationship between disease and bone metabolism genes. Our work was focused on 5q31 locus, which contains several genetic variants significantly associated with PsA. The study involved 1526 subjects (500 PsA, 426 PsV, 600 controls). The region was evaluated by selecting and genotyping the SNPs of interest by Real Time PCR and direct sequencing...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29219811/non-targeted-hiv-screening-in-emergency-departments-in-the-netherlands
#8
G P M Luiken, I K Joore, A Taselaar, S C E Schuit, S E Geerlings, A Govers, P P M Rood, J M Prins, B E Nichols, A Verbon, T E M S de Vries-Sluijs
BACKGROUND: In the Netherlands a substantial proportion of newly diagnosed human immunodeficiency virus (HIV) patients present late for care and an estimated 12-34% of people living with HIV are undiagnosed. Linkage to care of these patients is important to decrease HIV transmission and to improve individual patient outcomes. We investigated if non-targeted HIV testing in emergency departments is a useful and cost-effective way to identify these patients. METHODS: In a cross-sectional multicentre study, eligible adult patients who underwent phlebotomy were given an active choice to be additionally tested for HIV...
November 2017: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/29218792/complex-selection-on-a-regulator-of-social-cognition-evidence-of-balancing-selection-regulatory-interactions-and-population-differentiation-in-the-prairie-vole-avpr1a-locus
#9
Alejandro Berrio, Rafael F Guerrero, Galina V Aglyamova, Mariam Okhovat, Mikhail V Matz, Steven M Phelps
Adaptive variation in social behavior depends upon standing genetic variation, but we know little about how evolutionary forces shape genetic diversity relevant to brain and behavior. In prairie voles (Microtus ochrogaster), variants at the Avpr1a locus predict expression of the vasopressin 1a receptor in the retrosplenial cortex (RSC), a brain region that mediates spatial and contextual memory; cortical V1aR abundance in turn predicts diversity in space-use and sexual fidelity in the field. To examine the potential contributions of adaptive and neutral forces to variation at the Avpr1a locus, we explore sequence diversity at the Avpr1a locus and throughout the genome in two populations of wild prairie voles...
December 8, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/29218377/genetic-mapping-of-a-major-gene-in-triticale-conferring-resistance-to-bacterial-leaf-streak
#10
Aimin Wen, Malini Jayawardana, Jason Fiedler, Suraj Sapkota, Gongjun Shi, Zhao Peng, Sanzhen Liu, Frank F White, Adam J Bogdanove, Xuehui Li, Zhaohui Liu
A major gene conferring resistance to bacterial leaf streak was mapped to chromosome 5R in triticale. Bacterial leaf streak (BLS), caused by Xanthomonas translucens pv. undulosa (Xtu), is an important disease of wheat and triticale around the world. Although resistance to BLS is limited in wheat, several triticale accessions have high levels of resistance. To characterize the genetic basis of this resistance, we developed triticale mapping populations using a resistant accession (Siskiyou) and two susceptible accessions (UC38 and Villax St...
December 7, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/29217827/genome-wide-association-study-of-male-sexual-orientation
#11
Alan R Sanders, Gary W Beecham, Shengru Guo, Khytam Dawood, Gerulf Rieger, Judith A Badner, Elliot S Gershon, Ritesha S Krishnappa, Alana B Kolundzija, Jubao Duan, Pablo V Gejman, J Michael Bailey, Eden R Martin
Family and twin studies suggest that genes play a role in male sexual orientation. We conducted a genome-wide association study (GWAS) of male sexual orientation on a primarily European ancestry sample of 1,077 homosexual men and 1,231 heterosexual men using Affymetrix single nucleotide polymorphism (SNP) arrays. We identified several SNPs with p < 10-5, including regions of multiple supporting SNPs on chromosomes 13 (minimum p = 7.5 × 10-7) and 14 (p = 4.7 × 10-7). The genes nearest to these peaks have functions plausibly relevant to the development of sexual orientation...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29216901/genomic-variants-in-the-fto-gene-are-associated-with-sporadic-amyotrophic-lateral-sclerosis-in-greek-patients
#12
Konstantinos Mitropoulos, Eleni Merkouri Papadima, Georgia Xiromerisiou, Angeliki Balasopoulou, Kyriaki Charalampidou, Vasiliki Galani, Krystallia-Vassiliki Zafeiri, Efthymios Dardiotis, Styliani Ralli, Georgia Deretzi, Anne John, Kyriaki Kydonopoulou, Elpida Papadopoulou, Alba di Pardo, Fulya Akcimen, Annalisa Loizedda, Valerija Dobričić, Ivana Novaković, Vladimir S Kostić, Clint Mizzi, Brock A Peters, Nazli Basak, Sandro Orrù, Evangelos Kiskinis, David N Cooper, Spyridon Gerou, Radoje Drmanac, Marina Bartsakoulia, Evangelia-Eirini Tsermpini, Georgios M Hadjigeorgiou, Bassam R Ali, Theodora Katsila, George P Patrinos
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a devastating disease whose complex pathology has been associated with a strong genetic component in the context of both familial and sporadic disease. Herein, we adopted a next-generation sequencing approach to Greek patients suffering from sporadic ALS (together with their healthy counterparts) in order to explore further the genetic basis of sporadic ALS (sALS). RESULTS: Whole-genome sequencing analysis of Greek sALS patients revealed a positive association between FTO and TBC1D1 gene variants and sALS...
December 8, 2017: Human Genomics
https://www.readbyqxmd.com/read/29216560/identification-of-an-oxime-containing-c-glucosylarene-as-a-potential-inhibitor-of-sodium-dependent-glucose-co-transporter-2
#13
Mao-Chia Yuan, Teng-Kuang Yeh, Chiung-Tong Chen, Jen-Shin Song, Yu-Chen Huang, Tsung-Chih Hsieh, Chung-Yu Huang, Yu-Ling Huang, Min-Hsien Wang, Szu-Huei Wu, Chun-Hsu Yao, Yu-Sheng Chao, Jinq-Chyi Lee
Treatment of hyperglycemia with drugs that block renal glucose reabsorption via inhibition of sodium-dependent glucose cotransporter 2 (SGLT2) is a novel approach to diabetes management. In this study, twenty-seven aryl C-glycosides bearing a C=N/C-N linkage at the glucosyl C6 position were designed, synthesized and evaluated for their inhibitory activity against human SGLT2 (hSGLT2). Compounds with good hSGLT2 inhibition were further investigated to determine their selectivity over hSGLT1. Of these, five representative aryl C-glycosides were chosen for pharmacokinetic analysis...
November 10, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29216335/introgression-of-aegilops-speltoides-segments-in-triticum-aestivum-and-the-effect-of-the-gametocidal-genes
#14
Julie King, Surbhi Grewal, Cai-Yun Yang, Stella Hubbart Edwards, Duncan Scholefield, Stephen Ashling, John A Harper, Alexandra M Allen, Keith J Edwards, Amanda J Burridge, Ian P King
Background and Aims: Bread wheat (Triticum aestivum) has been through a severe genetic bottleneck as a result of its evolution and domestication. It is therefore essential that new sources of genetic variation are generated and utilized. This study aimed to generate genome-wide introgressed segments from Aegilops speltoides. Introgressions generated from this research will be made available for phenotypic analysis. Methods: Aegilops speltoides was crossed as the male parent to T...
December 5, 2017: Annals of Botany
https://www.readbyqxmd.com/read/29215122/diarylmaleimide-based-branched-oligomers-strong-full-color-emission-in-both-solution-and-solid-films
#15
Jingwei Wang, Rong Zheng, Huan Chen, Huimei Yao, Liyu Yan, Jie Wei, Zhenghuan Lin, Qidan Ling
Maleimide and benzene are employed as a dendron and a core, respectively, to construct two series of non-conjugate branched oligomers (B3G1 and B1G2) based on diarylmaleimide fluorophores by an alkylation reaction. Surface aryl groups are changed to tune the emissive color of branched oligomers from blue (λem = 480 nm) to red (λem = 651 nm), realizing full-color emission. The investigation on the photophysical properties of the oligomers indicates that they display intense emission in both solution and solid films, due to the suppression of intramolecular rotation and intermolecular interaction...
December 7, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29215121/stabilizing-benzene-like-planar-n6-rings-to-form-a-single-atomic-honeycomb-ben3-sheet-with-high-carrier-mobility
#16
Xiaoyin Li, Shunhong Zhang, Cunzhi Zhang, Qian Wang
It is a longstanding quest to use the planar N6 ring as a structural unit to build stable atomic sheets. However, unlike C6H6, the neutral N6 ring is unstable due to the strong repulsion of the lone-pair of electrons. Using first-principles calculations and the global structure search method, we show that the N6 unit can be stabilized by the linkage of Be atoms, forming a h-BeN3 honeycomb monolayer, in which the geometry and the π-molecular orbitals of the N6 rings are well kept. This sheet is not only energetically, dynamically and thermally stable, but also can withstand high temperatures up to 1000 K...
December 7, 2017: Nanoscale
https://www.readbyqxmd.com/read/29214741/laccase-catalyzed-synthesis-of-low-molecular-weight-lignin-like-oligomers-and-their-application-as-uv-blocking-materials
#17
Balamurugan Ramalingam, Jieyan Lim, Ranganathan Krishnan, Jayasree Seayad, Barindra Sana, Farid John Ghadessy, Satyasankar Jana
Laccase-catalyzed oxidative polymerization of monomeric and dimeric lignin model compounds was carried out using oxygen as oxidant in aqueous medium. The oligomers were characterized by gel permeation chromatography (GPC) and matrix assisted laser desorption ionisation time-of-flight mass spectroscopy (MALDI-TOF-MS) analysis. The oxidative polymerization leads to the formation of oligomeric species with a number average molecular weight (Mn) ranging between 700-2300 Da with low polydispersity index. Spectroscopic analysis provided insight into the possible modes of linkages present in the oligomers and the oligomerization is likely to proceed through the formation of C-C linkages between phenolic aromatic rings...
December 6, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29214520/high-density-snp-and-dart-based-genetic-linkage-maps-of-two-closely-related-oil-palm-populations
#18
Siou Ting Gan, Wei Chee Wong, Choo Kien Wong, Aik Chin Soh, Andrzej Kilian, Eng-Ti Leslie Low, Festo Massawe, Sean Mayes
Oil palm (Elaeis guineensis Jacq.) is an outbreeding perennial tree crop with long breeding cycles, typically 12 years. Molecular marker technologies can greatly improve the breeding efficiency of oil palm. This study reports the first use of the DArTseq platform to genotype two closely related self-pollinated oil palm populations, namely AA0768 and AA0769 with 48 and 58 progeny respectively. Genetic maps were constructed using the DArT and SNP markers generated in combination with anchor SSR markers. Both maps consisted of 16 major independent linkage groups (2n = 2× = 32) with 1399 and 1466 mapped markers for the AA0768 and AA0769 populations, respectively, including the morphological trait "shell-thickness" (Sh)...
December 6, 2017: Journal of Applied Genetics
https://www.readbyqxmd.com/read/29214367/subtercola-vilae-sp-nov-a-novel-actinobacterium-from-an-extremely-high-altitude-cold-volcano-lake-in-chile
#19
Alvaro S Villalobos, Jutta Wiese, Pablo Aguilar, Cristina Dorador, Johannes F Imhoff
A novel actinobacterium, strain DB165T, was isolated from cold waters of Llullaillaco Volcano Lake (6170 m asl) in Chile. Phylogenetic analysis based on 16S rRNA gene sequences identified strain DB165T as belonging to the genus Subtercola in the family Microbacteriaceae, sharing 97.4% of sequence similarity with Subtercola frigoramans DSM 13057T, 96.7% with Subtercola lobariae DSM 103962T, and 96.1% with Subtercola boreus DSM 13056T. The cells were observed to be Gram-positive, form rods with irregular morphology, and to grow best at 10-15 °C, pH 7 and in the absence of NaCl...
December 6, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29214222/reasons-to-pursue-a-career-in-medicine-a-qualitative-study-in-sierra-leone
#20
Aniek Woodward, Suzanne Thomas, Mohamed Bella Jalloh, John Rees, Andrew Leather
Background: Many low-income and crises-affected countries like Sierra Leone struggle with the recruitment and retention of their health professionals, particularly nurses and doctors. There are multiple factors that influence the 'recruitment to retention' pipeline. The first stage of an exploration into the issues influencing the availability of qualified health care workers may focus on the aspects which influence their entry into relevant educational programmes. This paper explores the reasons given by junior doctors in Sierra Leone for wanting to become a doctor...
2017: Global Health Research and Policy
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