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https://www.readbyqxmd.com/read/28453464/ppargc1a-and-adipoq-polymorphisms-are-associated-with-aggressive-prostate-cancer-in-mexican-mestizo-men-with-overweight-or-obesity
#1
Patricia Canto, Jesús Benítez Granados, Guillermo Feria-Bernal, Ramón Mauricio Coral-Vázquez, Eduardo García-García, María Elena Tejeda, André Tapia, David Rojano-Mejía, Juan Pablo Méndez
BACKGROUND: Obesity constitutes a risk factor for the development of aggressive forms of prostate cancer. It has been proposed, that prostate cancer has a genetic predisposition and that PPARGC1A and ADIPOQ polymorphisms play a role in the development of this condition. OBJECTIVE: To analyse the association of two PPARGC1A and ADIPOQ polymorphisms as well as their haplotypes, with the development of aggressive prostate cancer in Mexican-Mestizo men with overweight or obesity...
April 19, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28449385/linkage-to-hiv-care-after-home-based-hiv-counselling-and-testing-in-sub-saharan-africa-a-systematic-review
#2
REVIEW
Eugene Ruzagira, Kathy Baisley, Anatoli Kamali, Samuel Biraro, Heiner Grosskurth
BACKGROUND: Home-based HIV counselling and testing (HBHCT) has the potential to increase HIV testing uptake in sub-Saharan Africa (SSA) but data on linkage to HIV care after HBHCT are scarce. We conducted a systematic review of linkage to care after HBHCT in SSA. METHODS: Five databases were searched for studies published between 1(st) January 2000 and 19(th) August 2016 that reported on linkage to care among adults newly identified with HIV infection through HBHCT...
April 27, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28449084/perceived-quality-of-life-following-elder-mistreatment-in-rural-india
#3
Srinivasan Chokkanathan, Aravindhan Natarajan
Objectives: Using resilience theory, we examined multiple risks (individual, familial, and mistreatment characteristics) and promotive factors (mastery and social support) associated with perceived quality of life following mistreatment and tested two competing models, compensatory and protective models, to explain the role of promotive factors in the mistreatment-wellbeing linkage. Method: Face-to-face interviews were conducted by administering standardized instruments to 897 randomly selected older adults in rural Tamil Nadu, India...
April 26, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28448614/obtaining-retrotransposon-sequences-analysis-of-their-genomic-distribution-and-use-of-retrotransposon-derived-genetic-markers-in-lentil-lens-culinaris-medik
#4
Rita Rey-Baños, Luis E Sáenz de Miera, Pedro García, Marcelino Pérez de la Vega
Retrotransposons with long terminal repeats (LTR-RTs) are widespread mobile elements in eukaryotic genomes. We obtained a total of 81 partial LTR-RT sequences from lentil corresponding to internal retrotransposon components and LTRs. Sequences were obtained by PCR from genomic DNA. Approximately 37% of the LTR-RT internal sequences presented premature stop codons, pointing out that these elements must be non-autonomous. LTR sequences were obtained using the iPBS technique which amplifies sequences between LTR-RTs...
2017: PloS One
https://www.readbyqxmd.com/read/28448592/blood-type-abo-genetic-variants-and-ovarian-cancer-survival
#5
Gabriella D Cozzi, Rebecca T Levinson, Hilary Toole, Malcolm-Robert Snyder, Angie Deng, Marta A Crispens, Dineo Khabele, Alicia Beeghly-Fadiel
OBJECTIVE: Blood type A and the A1 allele have been associated with increased ovarian cancer risk. With only two small studies published to date, evidence for an association between ABO blood type and ovarian cancer survival is limited. METHODS: We conducted a retrospective cohort study of Tumor Registry confirmed ovarian cancer cases from the Vanderbilt University Medical Center with blood type from linked laboratory reports and ABO variants from linked Illumina Exome BeadChip data...
2017: PloS One
https://www.readbyqxmd.com/read/28447138/-endocrine-disruptors-evidence-from-epidemiological-studies-necessitates-a-critical-review-of-model-systems
#6
REVIEW
M Hoffmann, S Gebauer, M Nüchter, R Baber, J Ried, M von Bergen, W Kiess
Endocrine disruptive chemicals (EDCs) cause adverse health effects through interaction with endocrine systems. They are classified by chemical structure, effects on specific endocrine systems, bioaccumulation, persistence in the environment, or clinically observable effects. For research of the complex mechanisms of action in the human body, only in vitro model systems have so far been available, that have insufficient high-throughput capacity, which makes risk evaluation more difficult. In addition, in industrial nations, living people are often exposed to mixtures of substances, with various effects...
April 26, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28444211/effects-of-sample-size-and-full-sibs-on-genetic-diversity-characterization-a-case-study-of-three-syntopic-iberian-pond-breeding-amphibians
#7
Gregorio Sánchez-Montes, Arturo H Ariño, José L Vizmanos, Jinliang Wang, Íñigo Martínez-Solano
Accurate characterization of genetic diversity is essential for understanding population demography, predicting future trends and implementing efficient conservation policies. For that purpose, molecular markers are routinely developed for non-model species, but key questions regarding sampling design, like calculation of minimum sample sizes or the effect of relatives in the sample, are often neglected. We used accumulation curves and sibship analyses to explore how these two factors affect marker performance in the characterization of genetic diversity...
April 24, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/28444202/application-of-genomic-estimation-methods-of-inbreeding-and-population-structure-in-an-arabian-horse-herd
#8
Mohammed A Al Abri, Uta König von Borstel, Veronique Strecker, Samantha A Brooks
Horse breeders rely heavily on pedigrees for identification of ancestry in breeding stock. Inaccurate pedigrees may erroneously assign individuals to false lineages or breed memberships resulting in wrong estimates of inbreeding and coancestry. Moreover, discrepancies in pedigree records can lead breeders seeking to limit inbreeding into making misguided breeding decisions. Genome-wide SNPs provide a quantitative tool to aid in the resolution of lineage assignments and the calculation of genomic measures of relatedness...
April 21, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/28444001/birth-weight-and-risk-of-childhood-solid-tumors-in-brazil-a-record-linkage-between-population-based-data-sets
#9
Neimar de Paula Silva, Rejane de Souza Reis, Rafael Garcia Cunha, Julio Fernando Oliveira, Fernanda Cristina da Silva de Lima, Maria Socorro Pombo-de-Oliveira, Marceli Oliveira Santos, Beatriz de Camargo
Objective: To analyze the relationship between the development of childhood solid tumors and 1) birth weight and 2) fetal growth, using two Brazilian population-based data sets. Methods: A case-cohort study was performed using two population-based data sets, and linkage between the Live Birth Information System (Sistema de Informação sobre Nascidos Vivos, SINASC) and 14 population-based cancer registries (PBCRs) was established. Four controls per case were chosen randomly from the SINASC data set...
April 20, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28443275/integration-of-hiv-testing-into-maternal-newborn-and-child-health-weeks-for-improved-case-finding-and-linkage-to-prevention-of-mother-to-child-transmission-services-in-benue-state-nigeria
#10
Olusoji Akinleye, Gideon Dura, Arjan de Wagt, Abiola Davies, Dick Chamla
BACKGROUND: In Nigeria, maternal, newborn, and child health (MNCH) weeks are campaign-like events designed to accelerate progress toward Millennium Development Goals. The authors examined whether integrating HIV testing into MNCH weeks was feasible and could lead to increased case finding and linkage to prevention of mother-to-child transmission (PMTCT) services. METHODS: Pregnant women attending MNCH week during the first week of December 2014 in 13 local government areas in Benue State were provided with HIV tests and referrals to PMTCT services...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28443159/genetic-markers-for-adolescent-idiopathic-scoliosis-on-chromosome-19p13-3-among-saudi-arabian-girls
#11
Abdallah Ahmad Al-Othman, Mir Sadat-Ali, Ahmed Sh Amer, Dakheel A Al-Dakheel
STUDY DESIGN: Prospective case-controlled study. PURPOSE: This study aimed to assess genetic influence in Saudi Arabian children with adolescent idiopathic scoliosis (AIS). OVERVIEW OF LITERATURE: The genetic locus linked to chromosome 19p for idiopathic scoliosis has been described. A pilot study conducted at King Fahd Hospital of the University, Al-Khobar showed that three microsatellite markers (D19S216, D19S894, and DS1034) of chromosome 19p13...
April 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/28443103/genotyping-by-sequencing-for-snp-based-linkage-analysis-and-identification-of-qtls-linked-to-fruit-quality-traits-in-japanese-plum-prunus-salicina-lindl
#12
Juan A Salazar, Igor Pacheco, Paulina Shinya, Patricio Zapata, Claudia Silva, Mallikarjuna Aradhya, Dianne Velasco, David Ruiz, Pedro Martínez-Gómez, Rodrigo Infante
Marker-assisted selection (MAS) in stone fruit (Prunus species) breeding is currently difficult to achieve due to the polygenic nature of the most relevant agronomic traits linked to fruit quality. Genotyping by sequencing (GBS), however, provides a large quantity of useful data suitable for fine mapping using Single Nucleotide Polymorphisms (SNPs) from a reference genome. In this study, GBS was used to genotype 272 seedlings of three F1 Japanese plum (Prunus salicina Lindl) progenies derived from crossing "98-99" (as a common female parent) with "Angeleno," "September King," and "September Queen" as male parents...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28442657/structural-characterization-and-biological-activities-of-a-novel-polysaccharide-from-phyllanthus-emblica
#13
Zihan Zeng, Wenjie Lv, Yongshuai Jing, Zhiyan Chen, Liyan Song, Ting Liu, Rongmin Yu
A novel water-soluble polysaccharide named PEPW80-1, with a molecular mass of 4.7 kDa, was isolated from the pulp tissues of Phyllanthus emblica, and purified by sephadex G-100 column and sephacryl S-300 HR chromatography. The structural features of PEPW80-1 were investigated by a combination of acid hydrolysis, periodate oxidation-Smith degradation, methylation analysis, gas chromatography-mass spectrometry, scanning electron microscope, Fourier transform infrared spectroscopy, and nuclear magnetic resonance spectroscopy...
April 25, 2017: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/28441955/self-in-compatibility-in-apricot-germplasm-is-controlled-by-two-major-loci-s-and-m
#14
Juan Vicente Muñoz-Sanz, Elena Zuriaga, Inmaculada López, María L Badenes, Carlos Romero
BACKGROUND: Apricot (Prunus armeniaca L.) exhibits a gametophytic self-incompatibility (GSI) system and it is mostly considered as a self-incompatible species though numerous self-compatible exceptions occur. These are mainly linked to the mutated S C-haplotype carrying an insertion in the S-locus F-box gene that leads to a truncated protein. However, two S-locus unlinked pollen-part mutations (PPMs) termed m and m' have also been reported to confer self-compatibility (SC) in the apricot cultivars 'Canino' and 'Katy', respectively...
April 26, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28441501/hooked-on-cryogels-a-carbamate-linker-based-depot-for-slow-drug-release
#15
Duygu Aydin, Mehmet Arslan, Amitav Sanyal, Rana Sanyal
Poly(ethylene glycol) (PEG) based bulk hydrogels and cryogels containing activated carbonate groups as amine reactive handles to facilitate drug conjugations through carbamate linkages were fabricated and evaluated as slow releasing drug reservoirs. As an initial approach, photopolymerization of N-hydroxysuccinimide (NHS)-activated carbonate functional group containing monomer and PEG-methacrylate in the presence of a crosslinker was utilized to obtain bulk hydrogels with high gel conversions. The resultant hydrogels possessed moderate water uptake (170-340 %) which was dependent on the monomer ratios...
April 25, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28441426/identification-of-genes-associated-with-dissociation-of-cognitive-performance-and-neuropathological-burden-multistep-analysis-of-genetic-epigenetic-and-transcriptional-data
#16
Charles C White, Hyun-Sik Yang, Lei Yu, Lori B Chibnik, Robert J Dawe, Jingyun Yang, Hans-Ulrich Klein, Daniel Felsky, Alfredo Ramos-Miguel, Konstantinos Arfanakis, William G Honer, Reisa A Sperling, Julie A Schneider, David A Bennett, Philip L De Jager
INTRODUCTION: The molecular underpinnings of the dissociation of cognitive performance and neuropathological burden are poorly understood, and there are currently no known genetic or epigenetic determinants of the dissociation. METHODS AND FINDINGS: "Residual cognition" was quantified by regressing out the effects of cerebral pathologies and demographic characteristics on global cognitive performance proximate to death. To identify genes influencing residual cognition, we leveraged neuropathological, genetic, epigenetic, and transcriptional data available for deceased participants of the Religious Orders Study (n = 492) and the Rush Memory and Aging Project (n = 487)...
April 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28441388/a-population-based-approach-for-implementing-change-from-opt-out-to-opt-in-research-permissions
#17
Elizabeth A Marshall, Jim C Oates, Azza Shoaibi, Jihad S Obeid, Melissa L Habrat, Robert W Warren, Kathleen T Brady, Leslie A Lenert
Due to recently proposed changes in the Common Rule regarding the collection of research preferences, there is an increased need for efficient methods to document opt-in research preferences at a population level. Previously, our institution developed an opt-out paper-based workflow that could not be utilized for research in a scalable fashion. This project was designed to demonstrate the feasibility of implementing an electronic health record (EHR)-based active opt-in research preferences program. The first phase of implementation required creating and disseminating a patient questionnaire through the EHR portal to populate discreet fields within the EHR indicating patients' preferences for future research study contact (contact) and their willingness to allow anonymised use of excess tissue and fluid specimens (biobank)...
2017: PloS One
https://www.readbyqxmd.com/read/28439621/qtl-mapping-of-domestication-and-diversifying-selection-related-traits-in-round-fruited-semi-wild-xishuangbanna-cucumber-cucumis-sativus-l-var-xishuangbannanesis
#18
Yupeng Pan, Shuping Qu, Kailiang Bo, Meiling Gao, Kristin R Haider, Yiqun Weng
QTL analysis revealed 11 QTL underlying flowering time and fruit size variation in the semi-wild Xishuangbanna cucumber, of which, FT6.2 and FS5.2 played the most important roles in determining photoperiod-dependent flowering time and round-fruit shape, respectively. Flowering time and fruit size are two important traits in domestication and diversifying selection in cucumber, but their genetic basis is not well understood. Here we reported QTL mapping results on flowering time and fruit size with F2 and F2:3 segregating populations derived from the cross between WI7200, a small fruited, early flowering primitive cultivated cucumber and WI7167, a round-fruited, later flowering semi-wild Xishuangbanna (XIS) cucumber...
April 24, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28438105/design-functionality-and-validity-of-the-swincare-a-web-based-application-used-to-administer-cancer-registry-records
#19
Giovanni Benedetto, Alessia Di Prima, Salvatore Sciacca, Giuseppe Grosso
We described the design of a web-based application (the Software Integrated Cancer Registry-SWInCaRe) used to administer data in a cancer registry and tested its validity and usability. A sample of 11,680 records was considered to compare the manual and automatic procedures. Sensibility and specificity, the Health IT Usability Evaluation Scale, and a cost-efficiency analysis were tested. Several data sources were used to build data packages through text-mining and record linkage algorithms. The automatic procedure showed small yet measurable improvements in both data linkage process and cancer cases estimation...
April 1, 2017: Health Informatics Journal
https://www.readbyqxmd.com/read/28437453/three-dominant-awnless-genes-in-common-wheat-fine-mapping-interaction-and-contribution-to-diversity-in-awn-shape-and-length
#20
Motohiro Yoshioka, Julio C M Iehisa, Ryoko Ohno, Tatsuro Kimura, Hiroyuki Enoki, Satoru Nishimura, Shuhei Nasuda, Shigeo Takumi
The awn is a long needle-like structure formed at the tip of the lemma in the florets of some grass species. It plays a role in seed dispersal and protection against animals, and can contribute to the photosynthetic activity of spikes. Three main dominant inhibitors of awn development (Hd, B1 and B2) are known in hexaploid wheat, but the causal genes have not been cloned yet and a genetic association with awn length diversity has been found only for the B1 allele. To analyze the prevalence of these three awning inhibitors, we attempted to predict the genotypes of 189 hexaploid wheat varieties collected worldwide using markers tightly linked to these loci...
2017: PloS One
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