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https://www.readbyqxmd.com/read/29679666/glutathione-sensitive-hollow-mesoporous-silica-nanoparticles-for-controlled-drug-delivery
#1
Seyyed Pouya Hadipour Moghaddam, Mostafa Yazdimamaghani, Hamidreza Ghandehari
Tunable glutathione (GSH)-sensitive hollow mesoporous silica nanoparticles (HMSiO2 NPs) were developed using a structural difference-based selective etching strategy. These organosilica hollow nanoparticles contained disulfide linkages (S-S) in the outer shell which were degraded by GSH. The particles were compared with their nonGSH-sensitive tetraethyl orthosilicate (TEOS) HMSiO2 counterparts in terms of their synthesis method, characterization, DOX release profile, and in vitro cytotoxicity in MCF-7 breast cancer cells...
April 18, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29679097/quantitative-trait-loci-qtls-for-water-use-and-crop-production-traits-co-locate-with-major-qtl-for-tolerance-to-water-deficit-in-a-fine-mapping-population-of-pearl-millet-pennisetum-glaucum-l-r-br
#2
Murugesan Tharanya, Jana Kholova, Kaliamoorthy Sivasakthi, Deepmala Seghal, Charles Tom Hash, Basker Raj, Rakesh Kumar Srivastava, Rekha Baddam, Thiyagarajan Thirunalasundari, Rattan Yadav, Vincent Vadez
Four genetic regions associated with water use traits, measured at different levels of plant organization, and with agronomic traits were identified within a previously reported region for terminal water deficit adaptation on linkage group 2. Close linkages between these traits showed the value of phenotyping both for agronomic and secondary traits to better understand plant productive processes. Water saving traits are critical for water stress adaptation of pearl millet, whereas maximizing water use is key to the absence of stress...
April 21, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/29678627/structural-and-functional-insights-into-rha-p-a-bacterial-gh106-%C3%AE-l-rhamnosidase-from-novosphingobium-sp-pp1y
#3
Francesca Mensitieri, Federica De Lise, Andrea Strazzulli, Marco Moracci, Eugenio Notomista, Valeria Cafaro, Emiliano Bedini, Matthew Howard Sazinsky, Marco Trifuoggi, Alberto Di Donato, Viviana Izzo
α-L-Rhamnosidases (α-RHAs, EC 3.2.1.40) are glycosyl hydrolases (GHs) hydrolyzing terminal α-L-rhamnose residues from different substrates such as heteropolysaccharides, glycosylated proteins and natural flavonoids. Although the possibility to hydrolyze rhamnose from natural flavonoids has boosted the use of these enzymes in several biotechnological applications over the past decades, to date only few bacterial rhamnosidases have been fully characterized and only one crystal structure of a rhamnosidase of the GH106 family has been described...
April 17, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29678131/secimtools-a-suite-of-metabolomics-data-analysis-tools
#4
Alexander S Kirpich, Miguel Ibarra, Oleksandr Moskalenko, Justin M Fear, Joseph Gerken, Xinlei Mi, Ali Ashrafi, Alison M Morse, Lauren M McIntyre
BACKGROUND: Metabolomics has the promise to transform the area of personalized medicine with the rapid development of high throughput technology for untargeted analysis of metabolites. Open access, easy to use, analytic tools that are broadly accessible to the biological community need to be developed. While technology used in metabolomics varies, most metabolomics studies have a set of features identified. Galaxy is an open access platform that enables scientists at all levels to interact with big data...
April 20, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29677190/a-haplotype-of-three-snps-in-fto-had-a-strong-association-with-body-composition-and-bmi-in-iranian-male-adolescents
#5
Naser Kalantari, Nastaran Keshavarz Mohammadi, Pantea Izadi, Saeid Doaei, Maryam Gholamalizadeh, Hassan Eini-Zinab, Tuire Salonurmi, Shahram Rafieifar, Reza Janipoor, Ghasem Azizi Tabesh
BACKGROUND: Single-nucleotide polymorphisms (SNPs), which are located in the first intron of the FTO gene, are reported to be associated with body weight and the body mass index (BMI). However, their effects on anthropometric measurements in adolescents are poorly understood. OBJECTIVE: This study aimed to investigate the association of three adjacent polymorphisms (rs9930506, rs9930501, & rs9932754) in the FTO gene with anthropometric indices in Iranian adolescent males...
2018: PloS One
https://www.readbyqxmd.com/read/29676763/drivers-of-microbiological-quality-of-household-drinking-water-a-case-study-in-rural-ethiopia
#6
Muhammed A Usman, Nicolas Gerber, Evita H Pangaribowo
This study aims at assessing the determinants of microbiological contamination of household drinking water under multiple-use water systems in rural areas of Ethiopia. For this analysis, a random sample of 454 households was surveyed between February and March 2014, and water samples from community sources and household storage containers were collected and tested for fecal contamination. The number of Escherichia coli (E. coli) colony-forming units per 100 mL water was used as an indicator of fecal contamination...
April 2018: Journal of Water and Health
https://www.readbyqxmd.com/read/29675902/demography-or-selection-on-linked-cultural-traits-or-genes-investigating-the-driver-of-low-mtdna-diversity-in-the-sperm-whale-using-complementary-mitochondrial-and-nuclear-genome-analyses
#7
Phillip A Morin, Andrew D Foote, C Scott Baker, Brittany L Hancock-Hanser, Kristin Kaschner, Bruce R Mate, Sarah L Mesnick, Victoria L Pease, Patricia E Rosel, Alana Alexander
Mitochondrial DNA has been heavily utilized in phylogeography studies for several decades. However, underlying patterns of demography and phylogeography may be misrepresented due to coalescence stochasticity, selection, variation in mutation rates, and cultural hitchhiking (linkage of genetic variation to culturally transmitted traits affecting fitness). Cultural hitchhiking has been suggested as an explanation for low genetic diversity in species with strong social structures, counteracting even high mobility, abundance and limited barriers to dispersal...
April 19, 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29674520/improved-use-of-small-reference-panels-for-conditional-and-joint-analysis-with-gwas-summary-statistics
#8
Yangqing Deng, Wei Pan
Due to issues of practicality and confidentiality of genomic data-sharing on a large scale, typically only meta- or mega-analyzed GWAS summary data, not individual-level data, are publicly available. Re-analyses of such GWAS summary data for a wide range of applications have become more and more common and useful, which often require the use of an external reference panel with individual-level genotypic data to infer linkage disequilibrium (LD) among genetic variants. However, with a small sample size in only hundreds, as for the most popular 1000 Genomes Project European sample, estimation errors for LD are not negligible, leading to often dramatically increased numbers of false positives in subsequent analyses of GWAS summary data...
April 19, 2018: Genetics
https://www.readbyqxmd.com/read/29674386/functional-characterization-of-a-glycosyltransferase-from-the-moss-physcomitrella-patens-involved-in-the-biosynthesis-of-a-novel-cell-wall-arabinoglucan
#9
Alison W Roberts, Jelle Lahnstein, Yves S Y Hsieh, Xiaohui Xing, Kuok Yap, Arielle M Chaves, Tess R Scavuzzo-Duggan, George Dimitroff, Andrew Lonsdale, Eric M Roberts, Vincent Bulone, Geoffrey B Fincher, Monika Susanne Doblin, Antony Bacic, Rachel A Burton
Mixed-linkage (1,3;1,4)-β-glucan (MLG), an abundant cell wall polysaccharide in the Poaceae, has been detected in ascomycetes, algae, and seedless vascular plants, but not in eudicots. Although MLG has not been reported in bryophytes, a predicted glycosyltransferase from the moss Physcomitrella patens (Pp3c12_24670) is similar to a bona fide ascomycete MLG synthase. We tested whether Pp3c12_24670 encodes an MLG synthase by expressing it in wild tobacco (Nicotiana benthamiana) and testing for release of diagnostic oligosaccharides from the cell walls by either lichenase or (1,4)-β-glucan endohydrolase...
April 19, 2018: Plant Cell
https://www.readbyqxmd.com/read/29674336/sex-differences-in-the-impact-of-body-mass-index-on-the-risk-of-future-atrial-fibrillation-insights-from-the-longitudinal-population-based-troms%C3%A3-study
#10
Jocasta Ball, Maja-Lisa Løchen, Tom Wilsgaard, Henrik Schirmer, Laila A Hopstock, Bente Morseth, Ellisiv B Mathiesen, Inger Njølstad, Sweta Tiwari, Ekaterina Sharashova
BACKGROUND: Atrial fibrillation (AF) prevalence is increasing, and body mass index (BMI) is a risk factor for AF. However, sex differences in the impact of BMI on AF risk have not been fully elucidated. METHODS AND RESULTS: Data from the fourth survey (1994-1995) of the Tromsø Study (Norway) were used to investigate the association of single-measurement BMI on future AF risk. To analyze the influence of BMI changes on AF risk, data from individuals who attended the third and fourth study surveys were used...
April 19, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29673959/a-200k-snp-chip-reveals-a-novel-pacific-salmon-louse-genotype-linked-to-differential-efficacy-of-emamectin-benzoate
#11
Amber M Messmer, Jong S Leong, Eric B Rondeau, Anita Mueller, Cody A Despins, David R Minkley, Matthew P Kent, Sigbjørn Lien, Brad Boyce, Diane Morrison, Mark D Fast, Joseph D Norman, Roy G Danzmann, Ben F Koop
Antiparasitic drugs such as emamectin benzoate (EMB) are relied upon to reduce the parasite load, particularly of the sea louse Lepeophtheirus salmonis, on farmed salmon. The decline in EMB treatment efficacy for this purpose is an important issue for salmon producers around the world, and particularly for those in the Atlantic Ocean where widespread EMB tolerance in sea lice is recognized as a significant problem. Salmon farms in the Northeast Pacific Ocean have not historically experienced the same issues with treatment efficacy, possibly due to the relatively large population of endemic salmonid hosts that serve to both redistribute surviving lice and dilute populations potentially under selection by introducing naïve lice to farms...
April 16, 2018: Marine Genomics
https://www.readbyqxmd.com/read/29673346/elements-for-harnessing-participatory-action-research-to-strengthen-health-managers-capacity-a-critical-interpretative-synthesis
#12
REVIEW
Moses Tetui, Joseph Mumba Zulu, Anna-Karin Hurtig, Elizabeth Ekirapa-Kiracho, Suzanne N Kiwanuka, Anna-Britt Coe
BACKGROUND: Health managers play a key role in ensuring that health services are responsive to the needs of the population. Participatory action research (PAR) is one of the approaches that have been used to strengthen managers' capacity. However, collated knowledge on elements for harnessing PAR to strengthen managers' capacity is missing. This paper bridges this gap by reviewing existing literature on the subject matter. METHODS: A critical interpretive synthesis method was used to interrogate eight selected articles...
April 19, 2018: Health Research Policy and Systems
https://www.readbyqxmd.com/read/29673105/linkage-disequilibrium-clustering-based-approach-for-association-mapping-with-tightly-linked-genome-wide-data
#13
Zitong Li, Petri Kemppainen, Pasi Rastas, Juha Merilä
Genome-wide association studies (GWAS) aim to identify genetic markers strongly associated with quantitative traits by utilizing linkage disequilibrium (LD) between candidate genes and markers. However, because of LD between nearby genetic markers, the standard GWAS approaches typically detect a number of correlated SNPs covering long genomic regions, making corrections for multiple testing overly conservative. Additionally, the high dimensionality of modern GWAS data poses considerable challenges for GWAS procedures such as permutation tests, which are computationally intensive...
April 19, 2018: Molecular Ecology Resources
https://www.readbyqxmd.com/read/29672841/mutant-myo1f-alters-the-mitochondrial-network-and-induces-tumor-proliferation-in-thyroid-cancer
#14
Chiara Diquigiovanni, Christian Bergamini, Cecilia Evangelisti, Federica Isidori, Andrea Vettori, Natascia Tiso, Francesco Argenton, Anna Costanzini, Luisa Iommarini, Hima Anbunathan, Uberto Pagotto, Andrea Repaci, Giulia Babbi, Rita Casadio, Giorgio Lenaz, Kerry J Rhoden, Anna Maria Porcelli, Romana Fato, Anne Bowcock, Marco Seri, Giovanni Romeo, Elena Bonora
Familial aggregation is a significant risk factor for the development of thyroid cancer and Familial Non-Medullary Thyroid Cancer (FNMTC) accounts for 5-7% of all NMTC. Whole Exome Sequencing analysis in the family affected by FNMTC with oncocytic features where our group previously identified a predisposing locus on chromosome 19p13.2, revealed a novel heterozygous mutation (c.400G>A, NM_012335; p.Gly134Ser) in exon 5 of MYO1F, mapping to the linkage locus. In the thyroid FRTL-5 cell model stably expressing the mutant MYO1F p...
April 19, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29670604/itraq-based-quantitative-proteomic-analysis-of-a-toxigenic-dinoflagellate-alexandrium-catenella-and-its-non-toxigenic-mutant-exposed-to-a-cell-cycle-inhibitor-colchicine
#15
Shu-Fei Zhang, Yong Zhang, Lin Lin, Da-Zhi Wang
Paralytic shellfish toxins (PSTs) are a group of potent neurotoxic alkaloids mainly produced by marine dinoflagellates and their biosynthesis is associated with the cell cycle. Study shows that colchicine can cease cell division and inhibit PST production of dinoflagellates. However, the molecular mechanism behind this linkage is unknown. Here, we applied the iTRAQ-based proteomic approach to investigate protein expression profiles of a toxigenic dinoflagellate Alexandrium catenella (ACHK-T) and its non-toxigenic mutant (ACHK-NT) when treated with colchicine...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29670293/no-novel-high-penetrant-gene-might-remain-to-be-found-in-japanese-patients-with-unknown-mody
#16
Yukio Horikawa, Kazuyoshi Hosomichi, Mayumi Enya, Hiroyuki Ishiura, Yutaka Suzuki, Shoji Tsuji, Sumio Sugano, Ituro Inoue, Jun Takeda
MODY 5 and 6 have been shown to be low-penetrant MODYs. As the genetic background of unknown MODY is assumed to be similar, a new analytical strategy is applied here to elucidate genetic predispositions to unknown MODY. We examined to find whether there are major MODY gene loci remaining to be identified using SNP linkage analysis in Japanese. Whole-exome sequencing was performed with seven families with typical MODY. Candidates for novel MODY genes were examined combined with in silico network analysis. Some peaks were found only in either parametric or non-parametric analysis; however, none of these peaks showed a LOD score greater than 3...
April 18, 2018: Journal of Human Genetics
https://www.readbyqxmd.com/read/29669170/risk-factors-for-hepatocellular-carcinoma-by-age-sex-and-liver-disorder-status-a-prospective-cohort-study-in-korea
#17
Sang-Wook Yi, Ja-Sung Choi, Jee-Jeon Yi, Yong-Ho Lee, Ki Jun Han
BACKGROUND: To the authors' knowledge, relatively little is known regarding the interaction of risk factors for hepatocellular carcinoma (HCC) with age, sex, and liver disorder status. METHODS: The authors followed 504,646 Korean patients aged 40 to 80 years who underwent routine health checkups between 2002 and 2003 until 2013 via linkage to national hospital discharge records. RESULTS: HCC occurred in 2744 individuals. In the sex-adjusted and age-adjusted analysis, cirrhosis increased the incidence of HCC by 42-fold, followed by hepatitis B virus (21-fold), hepatitis C virus (HCV; 19-fold), male sex (4...
April 18, 2018: Cancer
https://www.readbyqxmd.com/read/29668745/correction-combined-bulked-segregant-sequencing-and-traditional-linkage-analysis-for-identification-of-candidate-gene-for-purple-leaf-sheath-in-maize
#18
Pengcheng Li, Cancan Du, Yingying Zhang, Shuangyi Yin, Enying Zhang, Huimin Fang, Dezhou Lin, Chenwu Xu, Zefeng Yang
[This corrects the article DOI: 10.1371/journal.pone.0190670.].
2018: PloS One
https://www.readbyqxmd.com/read/29668313/dietary-glycemic-load-glycemic-index-and-carbohydrate-intake-on-the-risk-of-lung-cancer-among-men-and-women-in-shanghai
#19
Jiang-Wei Sun, Wei Zheng, Hong-Lan Li, Jing Gao, Gong Yang, Yu-Tang Gao, Nat Rothman, Qing Lan, Xiao-Ou Shu, Yong-Bing Xiang
To investigate the potential influence of dietary glycemic index, glycemic load, or carbohydrate intake and lung cancer risk in Shanghai. We prospectively investigated the associations among 130,858 participants in the Shanghai Women's and Men's Health Studies. Diet was assessed using validated food-frequency questionnaires. Lung cancer cases were ascertained through annual record linkage and every 2-3 years in-home visits. Cox proportional hazard regression model was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs)...
April 18, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29668307/barriers-and-facilitators-for-clinical-care-engagement-among-hiv-positive-african-american-and-latino-men-who-have-sex-with-men
#20
James W Carey, Neal Carnes, Alisú Schoua-Glusberg, Katherine Kenward, Deborah Gelaude, Damian Denson, Elizabeth Gall, Laura A Randall, Paula M Frew
Achieving optimal health among people living with HIV (PLWH) requires linkage to clinical care upon diagnosis, followed by ongoing engagement in HIV clinical care. A disproportionate number of black/African American and Hispanic/Latino men who have sex with men (MSM) living with HIV do not, however, achieve ongoing care. We conducted semistructured interviews in 2014 with 84 urban black/African American and Hispanic/Latino MSM living with HIV to understand their barriers and facilitators to engagement. We classified men as care-engaged or not at the time of the interview, and conducted content analysis of the interview transcripts to identify barriers and facilitators to engagement...
April 18, 2018: AIDS Patient Care and STDs
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