Sara Abudahab, Mohamad M Kronfol, Mikhail G Dozmorov, Thomas Campbell, Fay M Jahr, Jasmine Nguyen, Ola AlAzzeh, Dalia Y Al Saeedy, Ashley Victor, Sera Lee, Shravani Malay, Dana M Lapato, Matthew S Halquist, MaryPeace McRae, Laxmikant S Deshpande, Patricia W Slattum, Elvin T Price, Joseph L McClay
Hepatic xenobiotic metabolism and transport decline with age, while intact xenobiotic metabolism is associated with longevity. However, few studies have examined the genome-wide impact of epigenetic aging on these processes. We used reduced representation bisulfite sequencing (RRBS) to map DNA methylation changes in liver DNA from mice ages 4 and 24 months. We identified several thousand age-associated differentially methylated sites (a-DMS), many of which overlapped genes encoding Phase I and Phase II drug metabolizing enzymes, in addition to ABC and SLC classes of transporters...
April 1, 2024: GeroScience