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https://www.readbyqxmd.com/read/29051674/mediterranean-diet-and-prevention-of-chronic-diseases
#1
Donato F Romagnolo, Ornella I Selmin
A large body of research data suggests that traditional dietary habits and lifestyle unique to the Mediterranean region (Mediterranean diet, MD) lower the incidence of chronic diseases and improve longevity. These data contrast with troubling statistics in the United States and other high income countries pointing to an increase in the incidence of chronic diseases and the projected explosion in cost of medical care associated with an aging population. In 2013, the MD was inscribed by UNESCO in the "Representative List of the Intangible Cultural Heritage of Humanity...
September 2017: Nutrition Today
https://www.readbyqxmd.com/read/29050820/gabab-receptor-modulation-to-b-or-not-to-be-b-a-pro-cognitive-medicine
#2
REVIEW
Jordi Serrats, Mark Oliver Cunningham, Ceri Hywel Davies
Metabotropic GABAB receptors clearly modify cognitive performance in preclinical animal models, yet translation to treating human disease has been elusive. Compared to their ionotropic GABAA receptor counterpart GABAB receptors not only regulate postsynaptic excitability but also regulate diverse synaptic inputs by presynaptically inhibiting neurotransmitter release. As such, the choice of agonist, antagonist, -ve or +ve modulator as well as CNS exposure level, timing of delivery and longevity of action strongly influence the probability of unlocking the procognitive potential of GABAB receptors in human disease...
October 16, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29048773/use-of-a-rho-kinase-inhibitor-to-increase-human-tonsil-keratinocyte-longevity-for-three-dimensional-tissue-engineered-tonsil-epithelium-equivalents
#3
Amy K Grayson, Vanessa Hearnden, Robert Bolt, Ala Jebreel, Helen E Colley, Craig Murdoch
The generation of tissue-engineered epithelial models is often hampered by the limited proliferative capacity of primary epithelial cells. This study aimed to isolate normal tonsillar keratinocytes (NTK) from human tonsils, increase the lifespan of these cells using the Rho kinase inhibitor Y-27632 and to develop tissue-engineered equivalents of healthy and infected tonsil epithelium. The proliferation rate of isolated NTK and expression of c-MYC and p16INK4A were measured in the absence or presence of the inhibitor...
October 19, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29045833/intestinal-fork-head-regulates-nutrient-absorption-and-promotes-longevity
#4
Ekin Bolukbasi, Mobina Khericha, Jennifer C Regan, Dobril K Ivanov, Jennifer Adcott, Miranda C Dyson, Tobias Nespital, Janet M Thornton, Nazif Alic, Linda Partridge
Reduced activity of nutrient-sensing signaling networks can extend organismal lifespan, yet the underlying biology remains unclear. We show that the anti-aging effects of rapamycin and reduced intestinal insulin/insulin growth factor (IGF) signaling (IIS) require the Drosophila FoxA transcription factor homolog Fork Head (FKH). Intestinal FKH induction extends lifespan, highlighting a role for the gut. FKH binds to and is phosphorylated by AKT and Target of Rapamycin. Gut-specific FKH upregulation improves gut barrier function in aged flies...
October 17, 2017: Cell Reports
https://www.readbyqxmd.com/read/29045571/zinc-induced-metallothionein-in-centenarian-offspring-from-a-large-european-population-the-mark-age-project
#5
Robertina Giacconi, Laura Costarelli, Francesco Piacenza, Andrea Basso, Alexander Bürkle, Maria Moreno-Villanueva, Tilman Grune, Daniela Weber, Wolfgang Stuetz, Efstathios S Gonos, Christiane Schön, Beatrix Grubeck-Loebenstein, Ewa Sikora, Olivier Toussaint, Florence Debacq-Chainiaux, Claudio Franceschi, Antti Hervonen, Eline Slagboom, Fabio Ciccarone, Michele Zampieri, Paola Caiafa, Eugène Jansen, Martijn E T Dollé, Nicolle Breusing, Eugenio Mocchegiani, Marco Malavolta
Metallothionein (MT) family are cysteine-rich proteins that regulate zinc (Zn) homeostasis and protect against oxidative damage. Studies in transgenic mice have shown that MT favourably influence longevity, although their role in human aging is not completely understood.Within the European multicenter study MARK-AGE, we analysed MT induction after Zn treatment in peripheral blood mononuclear cells (PBMCs) and its relation with redox biomarkers in 2936 age-stratified subjects (35-75 years) including the general population (RASIG), centenarian offspring (GO) and their spouses (SGO)...
October 17, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29032502/gut-microbiota-changes-in-the-extreme-decades-of-human-life-a-focus-on-centenarians
#6
REVIEW
Aurelia Santoro, Rita Ostan, Marco Candela, Elena Biagi, Patrizia Brigidi, Miriam Capri, Claudio Franceschi
The gut microbiota (GM) is a complex, evolutionarily molded ecological system, which contributes to a variety of physiological functions. The GM is highly dynamic, being sensitive to environmental stimuli, and its composition changes over the host's entire lifespan. However, the basic question of how much these changes may be ascribed to variables such as population, diet, genetics and gender, and/or to the aging process per se is still largely unanswered. We argue that comparison among studies on centenarians-the best model of healthy aging and longevity-recruited from different geographical areas/populations (different genetics and dietary habits) can help to disentangle the contribution of aging and non-aging-related variables to GM remodeling with age...
October 14, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29030599/genome-wide-meta-analysis-associates-hla-dqa1-drb1-and-lpa-and-lifestyle-factors-with-human-longevity
#7
Peter K Joshi, Nicola Pirastu, Katherine A Kentistou, Krista Fischer, Edith Hofer, Katharina E Schraut, David W Clark, Teresa Nutile, Catriona L K Barnes, Paul R H J Timmers, Xia Shen, Ilaria Gandin, Aaron F McDaid, Thomas Folkmann Hansen, Scott D Gordon, Franco Giulianini, Thibaud S Boutin, Abdel Abdellaoui, Wei Zhao, Carolina Medina-Gomez, Traci M Bartz, Stella Trompet, Leslie A Lange, Laura Raffield, Ashley van der Spek, Tessel E Galesloot, Petroula Proitsi, Lisa R Yanek, Lawrence F Bielak, Antony Payton, Federico Murgia, Maria Pina Concas, Ginevra Biino, Salman M Tajuddin, Ilkka Seppälä, Najaf Amin, Eric Boerwinkle, Anders D Børglum, Archie Campbell, Ellen W Demerath, Ilja Demuth, Jessica D Faul, Ian Ford, Alessandro Gialluisi, Martin Gögele, MariaElisa Graff, Aroon Hingorani, Jouke-Jan Hottenga, David M Hougaard, Mikko A Hurme, M Arfan Ikram, Marja Jylhä, Diana Kuh, Lannie Ligthart, Christina M Lill, Ulman Lindenberger, Thomas Lumley, Reedik Mägi, Pedro Marques-Vidal, Sarah E Medland, Lili Milani, Reka Nagy, William E R Ollier, Patricia A Peyser, Peter P Pramstaller, Paul M Ridker, Fernando Rivadeneira, Daniela Ruggiero, Yasaman Saba, Reinhold Schmidt, Helena Schmidt, P Eline Slagboom, Blair H Smith, Jennifer A Smith, Nona Sotoodehnia, Elisabeth Steinhagen-Thiessen, Frank J A van Rooij, André L Verbeek, Sita H Vermeulen, Peter Vollenweider, Yunpeng Wang, Thomas Werge, John B Whitfield, Alan B Zonderman, Terho Lehtimäki, Michele K Evans, Mario Pirastu, Christian Fuchsberger, Lars Bertram, Neil Pendleton, Sharon L R Kardia, Marina Ciullo, Diane M Becker, Andrew Wong, Bruce M Psaty, Cornelia M van Duijn, James G Wilson, J Wouter Jukema, Lambertus Kiemeney, André G Uitterlinden, Nora Franceschini, Kari E North, David R Weir, Andres Metspalu, Dorret I Boomsma, Caroline Hayward, Daniel Chasman, Nicholas G Martin, Naveed Sattar, Harry Campbell, Tōnu Esko, Zoltán Kutalik, James F Wilson
Genomic analysis of longevity offers the potential to illuminate the biology of human aging. Here, using genome-wide association meta-analysis of 606,059 parents' survival, we discover two regions associated with longevity (HLA-DQA1/DRB1 and LPA). We also validate previous suggestions that APOE, CHRNA3/5, CDKN2A/B, SH2B3 and FOXO3A influence longevity. Next we show that giving up smoking, educational attainment, openness to new experience and high-density lipoprotein (HDL) cholesterol levels are most positively genetically correlated with lifespan while susceptibility to coronary artery disease (CAD), cigarettes smoked per day, lung cancer, insulin resistance and body fat are most negatively correlated...
October 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/29030550/a-conserved-klf-autophagy-pathway-modulates-nematode-lifespan-and-mammalian-age-associated-vascular-dysfunction
#8
Paishiun N Hsieh, Guangjin Zhou, Yiyuan Yuan, Rongli Zhang, Domenick A Prosdocimo, Panjamaporn Sangwung, Anna H Borton, Evgenii Boriushkin, Anne Hamik, Hisashi Fujioka, Ciaran E Fealy, John P Kirwan, Maureen Peters, Yuan Lu, Xudong Liao, Diana Ramírez-Bergeron, Zhaoyang Feng, Mukesh K Jain
Loss of protein and organelle quality control secondary to reduced autophagy is a hallmark of aging. However, the physiologic and molecular regulation of autophagy in long-lived organisms remains incompletely understood. Here we show that the Kruppel-like family of transcription factors are important regulators of autophagy and healthspan in C. elegans, and also modulate mammalian vascular age-associated phenotypes. Kruppel-like family of transcription factor deficiency attenuates autophagy and lifespan extension across mechanistically distinct longevity nematode models...
October 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/29025355/a-content-analysis-of-testosterone-websites-sex-muscle-and-male-age-related-thematic-differences
#9
Nicholas Ivanov, Jimmy Vuong, Peter B Gray
Male testosterone supplementation is a large and growing industry. How is testosterone marketed to male consumers online? The present exploratory study entailed a content coding analysis of the home pages of 49 websites focused on testosterone supplementation for men in the United States. Four hypotheses concerning anticipated age-related differences in content coding were also tested: more frequent longevity content toward older men, and more frequent social dominance/physical formidability, muscle, and sex content toward younger men...
October 1, 2017: American Journal of Men's Health
https://www.readbyqxmd.com/read/29024905/hantavirus-maintenance-and-transmission-in-reservoir-host-populations
#10
REVIEW
Kristian M Forbes, Tarja Sironen, Alexander Plyusnin
Hantaviruses are primarily hosted by mammalian species of the orders Rodentia, Eulipotyphla and Chiroptera. Spillover to humans is common, and understanding hantavirus maintenance and transmission in reservoir host populations is important for efforts to curtail human disease. Recent field research challenges traditional phases of virus shedding kinetics derived from laboratory rodent infection experiments. Organ infection sites in non-rodent hosts suggest similar transmission routes to rodents, but require direct assessment...
October 9, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/29023742/oral-health-for-healthy-longevity-in-an-ageing-society-maintaining-momentum-and-moving-forward
#11
Kakuhiro Fukai, Hiroshi Ogawa, Patrick Hescot
The ageing of populations worldwide is rapidly accelerating. However, the global burden of oral disease remains a critical and often underestimated problem. As ageing progresses globally, oral health maintenance becomes a matter not only of public health, but also of human rights. Therefore, in low- and middle-income countries, policymakers are seeking to realize universal health coverage even as they struggle with severe resource limitations. To achieve and maintain global oral health, we propose an ongoing global monitoring cycle consisting of the following four steps: needs assessment, implementation of appropriate health care systems and provisions, reducing the global burden of oral disease, and working to achieve a healthy ageing society...
September 2017: International Dental Journal
https://www.readbyqxmd.com/read/29019964/building-iot-services-for-aging-in-place-using-standard-based-iot-platforms-and-heterogeneous-iot-products
#12
Sheik Mohammad Mostakim Fattah, Nak-Myoung Sung, Il-Yeup Ahn, Minwoo Ryu, Jaeseok Yun
An aging population and human longevity is a global trend. Many developed countries are struggling with the yearly increasing healthcare cost that dominantly affects their economy. At the same time, people living with old adults suffering from a progressive brain disorder such as Alzheimer's disease are enduring even more stress and depression than those patients while caring for them. Accordingly, seniors' ability to live independently and comfortably in their current home for as long as possible has been crucial to reduce the societal cost for caregiving and thus give family members peace of mind, called 'aging in place' (AIP)...
October 11, 2017: Sensors
https://www.readbyqxmd.com/read/28991186/relationships-among-environment-climate-and-longevity-in-china
#13
Yi Huang, Mark Rosenberg, Lingli Hou, Mengjin Hu
Human longevity is influenced by environment and nutrition. We considered environmental and nutritional factors relating to longevity in Chinese cities. We found higher 85+/65+ distribution ratios, indicating enhanced longevity, in the coastal and southern regions of China. These areas also featured higher humidity, low standard deviation of monthly temperature, higher levels of selenium (Se) distribution in soil, and greater sea fish consumption. Moderate climate is more conducive to longevity, however, there is no significant difference in longevity between different sub-climatic types within moderate climate; the relation between humidity and longevity is not always positive, the relation between altitude and longevity is not always negative...
October 8, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28988970/effects-of-berberine-curcumin-resveratrol-alone-and-in-combination-with-chemotherapeutic-drugs-and-signal-transduction-inhibitors-on-cancer-cells-power-of-nutraceuticals
#14
James A McCubrey, Stephen L Abrams, Kvin Lertpiriyapong, Lucio Cocco, Stefano Ratti, Alberto M Martelli, Saverio Candido, Massimo Libra, Ramiro M Murata, Pedro L Rosalen, Paolo Lombardi, Giuseppe Montalto, Melchiorre Cervello, Agnieszka Gizak, Dariusz Rakus, Linda S Steelman
Over the past fifty years, society has become aware of the importance of a healthy diet in terms of human fitness and longevity. More recently, the concept of the beneficial effects of certain components of our diet and other compounds, that are consumed often by different cultures in various parts of the world, has become apparent. These "healthy" components of our diet are often referred to as nutraceuticals and they can prevent/suppress: aging, bacterial, fungal and viral infections, diabetes, inflammation, metabolic disorders and cardiovascular diseases and have other health-enhancing effects...
October 3, 2017: Advances in Biological Regulation
https://www.readbyqxmd.com/read/28987323/the-longevity-gene-indy-i-m-not-dead-yet-in-metabolic-control-potential-as-pharmacological-target
#15
REVIEW
Diana M Willmes, Anica Kurzbach, Christine Henke, Grit Zahn, Alexander Heifetz, Jens Jordan, Stephen L Helfand, Andreas L Birkenfeld
The regulation of metabolic processes by the Indy (I'm Not Dead Yet) (SLC13A5/NaCT) gene was revealed through studies in Drosophila melanogaster and Caenorhabditis elegans. Reducing the expression of Indy in these species extended their life span by a mechanism resembling caloric restriction, without reducing food intake. In D. melanogaster, mutating the Indy gene reduced body fat content, insulin-like proteins and reactive oxygen species production. Subsequent studies indicated that Indy encodes a citrate transporter located on the cell plasma membrane...
October 4, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28983317/genetic-analysis-of-mitochondrial-ribosomal-proteins-and-cognitive-aging-in-postmenopausal-women
#16
Khyobeni Mozhui, Beverly M Snively, Stephen R Rapp, Robert B Wallace, Robert W Williams, Karen C Johnson
Genes encoding mitochondrial ribosomal proteins (MRPs) have been linked to aging and longevity in model organisms (i.e., mice, Caenorhabditis elegans). Here we evaluated if the MRPs have conserved effects on aging traits in humans. We utilized data from 4,504 participants of the Women's Health Initiative Memory Study (WHIMS) who had both longitudinal cognitive data and genetic data. Two aging phenotypes were considered: (1) gross lifespan (time to all-cause mortality), and (2) cognitive aging (longitudinal rate of change in modified mini-mental state scores)...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28977569/effects-of-foxo3-polymorphisms-on-survival-to-extreme-longevity-in-four-centenarian-studies
#17
Harold Bae, Anastasia Gurinovich, Alberto Malovini, Gil Atzmon, Stacy L Andersen, Francesco Villa, Nir Barzilai, Annibale Puca, Thomas T Perls, Paola Sebastiani
Previous studies note specific FOXO3 single-nucleotide polymorphisms (SNPs) associated with human longevity. However, it is not clear if these SNPs influence mortality risk beyond the oldest 1 percentile of survival. Using data from four longevity studies (total n = 8,266, age range 96-119 years for cases), we tested gene-wide association between 107 SNPs and survival to at least the oldest 1 percentile of survival for the 1900 birth cohort (≥96, white males; ≥100 white females). This analysis replicated 17 previously published variants, several of which are significant expression quantitative trait loci of FOXO3; rs6911407 and rs2253310 have the most significant effect on FOXO3 expressions in brain tissue...
July 18, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28973488/transcriptome-analysis-of-male-drosophila-melanogaster-exposed-to-ethylparaben-using-digital-gene-expression-profiling
#18
Peiqin Xue, Xiaojun Zhao, Mengbei Qin, Zhanghuan Shi, Min Zhang, Wei Gu
Ethylparaben (EP) has been shown to have estrogenic effects and can affect the normal development, longevity, and reproductive system of some animals. In this study, we investigated the effects of EP in male Drosophila melanogaster using transcriptome analysis or digital gene expression profiling. We then screened differentially expressed genes (DEGs) between the two groups (EP-treated and control group) of Drosophila, and performed clustering analysis, gene ontology (GO) function annotation, kyoto encyclopedia of gene and genomes metabolic pathway analysis...
July 1, 2017: Journal of Insect Science
https://www.readbyqxmd.com/read/28972881/alzheimer-s-disease-in-humans-and-other-animals-a-consequence-of-postreproductive-life-span-and-longevity-rather-than-aging
#19
Danièlle Gunn-Moore, Oksana Kaidanovich-Beilin, María Carolina Gallego Iradi, Frank Gunn-Moore, Simon Lovestone
Two diseases of the modern world-Alzheimer's and diabetes mellitus-are linked by epidemiology, genetics, and molecular pathogenesis. They may also be linked by the remarkable observation that insulin signaling sets the limits on longevity. In worms, flies, and mice, disrupting insulin signaling increases life span leading some to speculate that caloric restriction might extend life span in man. It is our contention that man is already a long-lived organism, specifically with a remarkably high postfertility life span, and that it is the reason that results in the high prevalence of Alzheimer's and diabetes...
September 30, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28971552/tor-mediated-regulation-of-metabolism-in-aging
#20
REVIEW
Henri Antikainen, Monica Driscoll, Gal Haspel, Radek Dobrowolski
Cellular metabolism is regulated by the mTOR kinase, a key component of the molecular nutrient sensor pathway that plays a central role in cellular survival and aging. The mTOR pathway promotes protein and lipid synthesis and inhibits autophagy, a process known for its contribution to longevity in several model organisms. The nutrient-sensing pathway is regulated at the lysosomal membrane by a number of proteins for which deficiency triggers widespread aging phenotypes in tested animal models. In response to environmental cues, this recently discovered lysosomal nutrient-sensing complex regulates autophagy transcriptionally through conserved factors, such as the transcription factors TFEB and FOXO, associated with lifespan extension...
October 2, 2017: Aging Cell
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