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https://www.readbyqxmd.com/read/28542630/dose-dependent-effect-of-silver-nanoparticles-agnps-on-fertility-and-survival-of-drosophila-an-in-vivo-study
#1
Akanksha Raj, Prasanna Shah, Namita Agrawal
Silver nanoparticles (AgNPs) containing consumer products have been proliferating in the market due to its unique antimicrobial property, however, lack of in-depth knowledge about their potential effect on human health in a longer run is of great concern. Therefore, we investigated dose-dependent in vivo effect of AgNPs using Drosophila as a model system. Drosophila, a genetically tractable organism with distinct developmental stages, short life cycle and significant homology with human serves as an ideal organism to study nanomaterial-mediated toxicity...
2017: PloS One
https://www.readbyqxmd.com/read/28539178/gender-marital-status-and-longevity
#2
REVIEW
Gemma Tatangelo, Marita McCabe, Stephen Campbell, Cassandra Szoeke
Most studies report a positive relationship between marital status and health, with findings consistent across cultures and countries. Gender effects are significant, with men demonstrating greater health benefit than women. The vast majority of the research has examined heterosexual marriages, yet there has been rapid evolution in society of cohabitation patterns, who can marry, and roles in marriage. In this review, we summarise research findings and discuss important future challenges. Broader work looking at the impact of social connectedness, loneliness and support on survival should be supported...
June 2017: Maturitas
https://www.readbyqxmd.com/read/28531243/increased-postural-sway-during-quiet-stance-as-a-risk-factor-for-prospective-falls-in-community-dwelling-elderly-individuals
#3
Jonas Johansson, Anna Nordström, Yngve Gustafson, Göran Westling, Peter Nordström
Objective: fall-related injuries constitute major health risks in older individuals, and these risks are projected to increase in parallel with increasing human longevity. Impaired postural stability is a potential risk factor related to falls, although the evidence is inconclusive, partly due to the lack of prospective studies. This study aimed to investigate how objective measures of postural sway predict incident falls. Design, setting and participants: this prospectively observational study included 1,877 community-dwelling individuals aged 70 years who participated in the Healthy Ageing Initiative between June 2012 and December 2015...
May 22, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28529840/adoptive-cell-therapy-with-tregs-to-improve-transplant-outcomes-the-promise-and-the-stumbling-blocks
#4
Mohamed B Ezzelarab, Angus W Thomson
The contribution of regulatory T cells (Treg) to the induction and maintenance of tolerance is well-recognized in rodents and may contribute to long-term human organ allograft survival. The therapeutic efficacy of adoptively-transferred Treg in promoting tolerance to organ allografts is well-recognized in mouse models. Early phase 1/2 clinical studies of Treg therapy have been conducted in patients with type-1 (autoimmune) diabetes and refractory Crohn's disease, and for inhibition of graft-versus-host disease following bone marrow transplantation with proven safety...
December 2016: Current Transplantation Reports
https://www.readbyqxmd.com/read/28526626/longevity-and-healthy-ageing-genes-foxo3a-and-sirt3-serum-protein-marker-and-new-road-map-to-burst-oxidative-stress-by-withania-somnifera
#5
Rashmita Pradhan, Rahul Kumar, Shashank Shekhar, Nitish Rai, Akash Ambashtha, Joyita Banerjee, Mona Pathak, S N Dwivedi, Sharmistha Dey, Aparajit B Dey
BACKGROUND: Ageing process is characterized by a decline in function; different age related diseases and excessive age associated mortality. There has always been a quest for easily accessible biomarkers to monitor and identify the development of age-associated stress for providing new anti-ageing strategies. Forkhead box protein O3A (FOXO3A) and Sirtuin3 (SIRT3) are such potential markers which plays important role in a wide variety of cellular mechanisms and has been proposed to be an ideal candidate to study longevity and are potential candidate for healthy ageing by oxidative burst...
May 16, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28520966/clonal-expansion-of-human-immunodeficiency-virus-infected-cells-and-human-immunodeficiency-virus-persistence-during-antiretroviral-therapy
#6
James I Mullins, Lisa M Frenkel
The latent HIV-1 reservoir in blood decays very slowly, even during prolonged suppression of viral replication by antiretroviral therapy (ART). Mechanisms for reservoir persistence include replenishment through low-level viral replication, longevity and homeostatic proliferation of memory T cells, and most recently appreciated, clonal expansion of HIV-infected cells. Clonally expanded cells make up a large and increasing fraction of the residual infected cell population on ART, and insertion of HIV proviruses into certain host cellular genes has been associated with this proliferation...
March 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28515893/evolutionary-stability-and-the-rarity-of-grandmothering
#7
Jared M Field, Michael B Bonsall
The provision of intergenerational care, via the Grandmother Hypothesis, has been implicated in the evolution of postfertile longevity, particularly in humans. However, if grandmothering does provide fitness benefits, a key question is why has it evolved so infrequently? We investigate this question with a combination of life-history and evolutionary game theory. We derive simple eligibility and stability thresholds, both of which must be satisfied if intergenerational care is first to evolve and then to persist in a population...
May 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28515780/evolution-and-the-duration-of-a-doomed-population
#8
Richard Gomulkiewicz, Stephen M Krone, Christopher H Remien
Many populations are doomed to extinction, but little is known about how evolution contributes to their longevity. We address this by modeling an asexual population consisting of genotypes whose abundances change independently according to a system of continuous branching diffusions. Each genotype is characterized by its initial abundance, growth rate, and reproductive variance. The latter two components determine the genotype's "risk function" which describes its per capita probability of extinction at any time...
June 2017: Evolutionary Applications
https://www.readbyqxmd.com/read/28513731/ag-au-nanoprism-metal-organic-framework-based-paper-for-extending-the-glucose-sensing-range-in-human-serum-and-urine
#9
Pin-Hsuan Huang, Chia Ping Hong, Jian Fan Zhu, Tzu-Ting Chen, Chu-Ting Chan, Yu-Chien Ko, Tien-Li Lin, Zheng-Bang Pan, Ning-Kuei Sun, Ying-Chu Wang, Jong-Jheng Luo, Tzu-Chieh Lin, Chia-Cheng Kang, Jing-Jong Shyue, Mei-Lin Ho
In this work, we present a Ag@Au nanoprism-metal-organic framework-paper based glucose sensor for rapid, sensitive, single-use and quantitative glucose determination in human serum. To achieve painless measurement of glucose with a non-invasive detection methodology, this biosensor was further tested in human urine. In this approach, a new hybrid-Ag@Au nanoprism loaded in close proximity to micrometer sized coordination polymers as phosphorescent luminophores significantly enhanced the emission intensity due to metal-enhanced phosphorescence and worked as reaction sites to support more dissolved oxygen...
May 17, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28512483/efficacy-of-different-root-canal-irrigants-on-smear-layer-removal-after-post-space-preparation-a-scanning-electron-microscopy-evaluation
#10
Rahele Mirseifinejad, Mehdi Tabrizizade, Abdolrahim Davari, Fateme Mehravar
INTRODUCTION: Effective durable adhesion between post material and dentine using resin cements is essential for longevity of restoration. The aim of this in vitro study was to compare the effect of different irrigants on smear layer removal after post space preparation. METHODS AND MATERIALS: A total of 75 extracted anterior human teeth were selected. The canals were instrumented by rotary system and then were filled. After preparing the post space, teeth were divided into 5 groups according to irrigants: 17% EDTA; 17% EDTA+2% CHX; 5...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28511559/migrating-microbes-what-pathogens-can-tell-us-about-population-movements-and-human-evolution
#11
Charlotte J Houldcroft, Jean-Baptiste Ramond, Riaan F Rifkin, Simon J Underdown
BACKGROUND: The biology of human migration can be observed from the co-evolutionary relationship with infectious diseases. While many pathogens are brief, unpleasant visitors to human bodies, others have the ability to become life-long human passengers. The story of a pathogen's genetic code may, therefore, provide insight into the history of its human host. The evolution and distribution of disease in Africa is of particular interest, because of the deep history of human evolution in Africa, the presence of a variety of non-human primates, and tropical reservoirs of emerging infectious diseases...
May 16, 2017: Annals of Human Biology
https://www.readbyqxmd.com/read/28511176/aging-and-the-inevitable-limit-to-human-life-span
#12
Jan Vijg, Eric Le Bourg
There is a long-lasting debate about a natural limit to human life span, and it has been argued that the maximum reported age at death, which has not increased for ca 25 years, fluctuates around 115 years, even if some persons live beyond this age. We argue that the close connection of species-specific longevity with life history strategies explains why human life span is limited and cannot reach the considerably longer life spans of several other species.
May 17, 2017: Gerontology
https://www.readbyqxmd.com/read/28510085/cardiac-aging-and-heart-disease-in-humans
#13
REVIEW
Marja Steenman, Gilles Lande
The world population continues to grow older rapidly, mostly because of declining fertility and increasing longevity. Since age represents the largest risk factor for cardiovascular disease, the prevalence of these pathologies increases dramatically with increasing age. In order to improve patient care and prevention for age-related cardiac diseases, insight should be gained from the analysis of processes involved in and leading to cardiac aging. It is from this perspective that we provide here an overview of changes associated with age in the heart on four levels: functional, structural, cellular and molecular...
April 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28497122/the-microbiome-mitochondrion-connection-common-ancestries-common-mechanisms-common-goals
#14
Alfredo Franco-Obregón, Jack A Gilbert
Lynn Margulis in the 1960s elegantly proposed a shared phylogenetic history between bacteria and mitochondria; this relationship has since become a cornerstone of modern cellular biology. Yet, an interesting facet of the interaction between the microbiome and mitochondria has been mostly ignored, that of the systems biology relationship that underpins host health and longevity. The mitochondria are descendants of primordial aerobic pleomorphic bacteria (likely genus Rickettsia) that entered (literally and functionally) into a mutualistic partnership with ancient anaerobic microbes (likely Archaea)...
May 2017: MSystems
https://www.readbyqxmd.com/read/28492829/inequalities-in-life-expectancy-among-us-counties-1980-to-2014-temporal-trends-and-key-drivers
#15
Laura Dwyer-Lindgren, Amelia Bertozzi-Villa, Rebecca W Stubbs, Chloe Morozoff, Johan P Mackenbach, Frank J van Lenthe, Ali H Mokdad, Christopher J L Murray
Importance: Examining life expectancy by county allows for tracking geographic disparities over time and assessing factors related to these disparities. This information is potentially useful for policy makers, clinicians, and researchers seeking to reduce disparities and increase longevity. Objective: To estimate annual life tables by county from 1980 to 2014; describe trends in geographic inequalities in life expectancy and age-specific risk of death; and assess the proportion of variation in life expectancy explained by variation in socioeconomic and race/ethnicity factors, behavioral and metabolic risk factors, and health care factors...
May 8, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28484723/interleukin-7-and-immunosenescence
#16
REVIEW
Vanloan Nguyen, Andrew Mendelsohn, James W Larrick
The age of an individual is an important, independent risk factor for many of the most common diseases afflicting modern societies. Interleukin-7 (IL-7) plays a central, critical role in the homeostasis of the immune system. Recent studies support a critical role for IL-7 in the maintenance of a vigorous healthspan. We describe the role of IL-7 and its receptor in immunosenescence, the aging of the immune system. An understanding of the role that IL-7 plays in aging may permit parsimonious preventative or therapeutic solutions for diverse conditions...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28482934/longevity-in-north-korea-and-south-korea-prevalence-of-centenarians-in-one-the-poorest-and-one-of-the-richest-nations
#17
Daniel Schwekendiek
Over recent decades, economic living conditions have dramatically improved in South Korea, which now represents one of the most developed nations. At the same time, its twin in the North remains one of the poorest countries on earth. Thus, the Korean peninsula represents a unique historical experiment that allows for study of the effects of environment on human development under a variety of ceteris paribus cultural, genetic and climatic conditions. Previous studies comparing the biosocial performances of the two Koreas have focused on indicators such as weight, height, mid-upper arm circumference and age at menarche...
May 9, 2017: Journal of Biosocial Science
https://www.readbyqxmd.com/read/28482501/metallic-powder-bed-based-3d-printing-of-cellular-scaffolds-for-orthopaedic-implants-a-state-of-the-art-review-on-manufacturing-topological-design-mechanical-properties-and-biocompatibility
#18
REVIEW
X P Tan, Y J Tan, C S L Chow, S B Tor, W Y Yeong
Metallic cellular scaffold is one of the best choices for orthopaedic implants as a replacement of human body parts, which could improve life quality and increase longevity for the people needed. Unlike conventional methods of making cellular scaffolds, three-dimensional (3D) printing or additive manufacturing opens up new possibilities to fabricate those customisable intricate designs with highly interconnected pores. In the past decade, metallic powder-bed based 3D printing methods emerged and the techniques are becoming increasingly mature recently, where selective laser melting (SLM) and selective electron beam melting (SEBM) are the two representatives...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28479447/design-of-a-pulsatile-fresh-frozen-human-cadaver-circulation-model-for-endovascular-training
#19
Nesbitt C, Williams R, McCaslin J, Searle R, Mafeld S, Stansby G
OBJECTIVES: The objective of this project was to create a model capable of training endovascular skills using a freshly frozen human cadaver (HC). We present the results of our experience creating a cadaveric model for endovascular skills training. DESIGN: We undertook a unique cadaver laboratory based research project. MATERIALS AND METHODS: We favour a minimally invasive surgical technique with inflow into the right common carotid artery and outflow through the left common femoral and right superficial femoral arteries...
May 4, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28472634/learning-of-nature-the-curious-case-of-the-naked-mole-rat
#20
REVIEW
Francisco Alejandro Lagunas-Rangel, Venice Chávez-Valencia
Naked mole rats (NMRs) are the longest-living rodents known, living up to approximately 30 years and showing sustained good health. Nowadays, NMRs are considered excellent models for aging and, additionally, for cancer research, due to the evidence of a remarkable cancer resistance demonstrated through thousands of necropsies performed with very few cases that describe this pathology, which is believed to be a disease that unavoidably accompanies aging. Since some years ago, several studies have tried to explain the possible mechanisms underlying longevity and cancer resistance in NMRs through different perspectives and directions, creating new knowledge that subsequently could be used for cancer prevention and delaying aging in humans...
May 1, 2017: Mechanisms of Ageing and Development
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