keyword
https://read.qxmd.com/read/38535341/development-of-a-technique-using-artificial-membrane-for-in-vitro-rearing-of-body-lice-pediculus-humanus-humanus
#1
JOURNAL ARTICLE
Alissa Hammoud, Meriem Louni, Linda Abou-Chacra, Gabriel Haddad, Noelle Mazzotti, Florence Fenollar, Oleg Mediannikov
Human lice are the only hematophagous ectoparasites specific to human hosts. They transmit epidemic typhus, trench fever and relapsing fever, diseases which have already caused millions of deaths worldwide. In order to further investigate lice vectorial capacities, laboratory-controlled live lice colonies are essential. Previously developed lice-rearing methods significantly advanced research on louse-borne diseases and louse biology. In this study, we aimed to develop a rearing technique for the Orlando (Or) strain of body lice on an artificial membrane...
February 21, 2024: Insects
https://read.qxmd.com/read/38531263/unconditional-cash-transfers-health-and-savings
#2
JOURNAL ARTICLE
Sefa Awaworyi Churchill, Nasir Iqbal, Saima Nawaz, Siew Ling Yew
This paper examines the relationship between a national unconditional cash transfers (UCTs) program, health and savings. We theoretically and empirically show that motives to save can be strong when cash transfers promote health outcomes. We first present a theoretical model that considers lifecycle-consumption savings decisions, where households derive utility from consumption and leisure time at working age, as well as old-age consumption and old-age longevity that positively depend on health spending. We then empirically examine the impact of Pakistan's Benazir Income Support Programme on various indicators of savings and provide suggestive evidence on how UCTs influence savings via health...
March 15, 2024: Economics and Human Biology
https://read.qxmd.com/read/38530973/soft-and-hard-tissue-integration-around-percutaneous-bone-anchored-titanium-prostheses-toward-achieving-holistic-biointegration
#3
REVIEW
Sangeeta Shrivas, Harshita Samaur, Vinod Yadav, Sunil Kumar Boda
A holistic biointegration of percutaneous bone-anchored metallic prostheses with both hard and soft tissues dictates their longevity in the human body. While titanium (Ti) has nearly solved osseointegration, soft tissue integration of percutaneous metallic prostheses is a perennial problem. Unlike the firm soft tissue sealing in biological percutaneous structures (fingernails and teeth), foreign body response of the skin to titanium (Ti) leads to inflammation, epidermal downgrowth and inferior peri-implant soft tissue sealing...
March 26, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38529607/gene-therapy-for-skin-aging
#4
JOURNAL ARTICLE
Fawzy A Saad
Extrinsic and intrinsic factors contribute to skin aging; nonetheless, they are intertwined. Moreover, intrinsic skin aging mirrors age-related declines in the entire human body's internal organs. There is evidence that skin appearance is an indicator of the general health of somebody. Earlier, it was apparent that the intrinsic factors are unalterable, but the sparkling of skin aging gene therapy on the horizon is changing this narrative. Skin aging gene therapy offers tools for skin rejuvenation and, natural beauty restoration, and therapy for diseases affecting the entire skin...
March 25, 2024: Current Gene Therapy
https://read.qxmd.com/read/38519334/silk-hyaluronic-acid-for-vocal-fold-augmentation-safety-profile-and-long-term-voice-outcomes
#5
JOURNAL ARTICLE
Christopher D Dwyer, Samantha Kridgen, Simon Chiang, Mira Fein, Carly Forrester, Lindsey Gordon, Douglas F Roth, Jennifer J Shin, Jennifer Winston, Thomas L Carroll
OBJECTIVES: Silk-hyaluronic acid (silk-HA) is a novel vocal fold augmentation material used in humans since July 2020. We aim to describe indications, voice outcomes, and longevity data for silk-HA injectable when used for vocal fold injection (VFI) augmentation in a large cohort of patients with longer-term follow-up than preliminary clinical studies. METHODS: Retrospective chart review of Silk-HA injections for glottic insufficiency (GI) and follow-up between July 2020 and November 2023...
March 21, 2024: Journal of Voice
https://read.qxmd.com/read/38518394/the-crucial-role-of-diverse-animal-models-to-investigate-cochlear-aging-and-hearing-loss
#6
REVIEW
Karen Castaño-González, Christine Köppl, Sonja J Pyott
Age-related hearing loss affects a large and growing segment of the population, with profound impacts on quality of life. Age-related pathology of the cochlea-the mammalian hearing organ-underlies age-related hearing loss. Because investigating age-related changes in the cochlea in humans is challenging and often impossible, animal models are indispensable to investigate these mechanisms as well as the complex consequences of age-related hearing loss on the brain and behavior. In this review, we advocate for a comparative and interdisciplinary approach while also addressing the challenges of comparing age-related hearing loss across species with varying lifespans...
March 11, 2024: Hearing Research
https://read.qxmd.com/read/38518282/exploring-tribology-and-material-contact-science-in-spine-surgery-implications-for-implant-design
#7
JOURNAL ARTICLE
Gabrielle Scariano, Seth Meade, Assem Sultan, Michael Shost, Edward C Benzel, Ajit Krishnaney, Thomas Mroz, Michael P Steinmetz, Ghaith Habboub
Tribology, an interdisciplinary field concerned with the science of interactions between surfaces in contact and their relative motion, plays a well-established role in the design of orthopedic implants, such as knee and hip replacements. However, its applications in spine surgery have received comparatively less attention in the literature. Understanding tribology is pivotal in elucidating the intricate interactions between metal, polymer, and ceramic components, as well as their interplay with the native human bone...
March 22, 2024: Journal of Neurosurgery. Spine
https://read.qxmd.com/read/38517921/transgenerational-effects-of-pyriproxyfen-in-a-field-strain-of-musca-domestica-l-diptera-muscidae
#8
JOURNAL ARTICLE
Naeem Iqbal, Nauman Sadiq, Muhammad Nadir Naqqash, Muhammad Usman, Hafiz Azhar Ali Khan, Allah Ditta Abid, Muhammad Sohail Shahzad
Musca domestica L. (Muscidae: Diptera) is a human and livestock pest especially in tropical and sub-tropical areas. Different insecticides have been used to control this pest that pose serious harmful effects on humans and the environment. The current study was planned to investigate the effects of two concentrations (LC25 and LC50) of pyriproxyfen on biological and population parameters of a field strain of M. domestica. The exposed parents (F0) and their progeny (F1) were studied to examine the transgenerational effects...
2024: PloS One
https://read.qxmd.com/read/38516365/grandmother-effects-over-the-finnish-demographic-transition
#9
JOURNAL ARTICLE
Simon N Chapman, Virpi Lummaa
Demographic transitions are defining events for human societies, marking shifts from natural mortality and fertility rates to the low rates seen in industrialised populations. These transitions can affect trait evolution through altering the direction and strength of selection when variance in fertility and mortality decline. One key feature of human evolution is the evolution of extended post-reproductive life through indirect fitness benefits from grandmothering. Although studies in pre- and post-transition societies have documented beneficial grandmother presence, it remains unknown whether these associations changed before, during, or after the transition...
2024: Evolutionary human sciences
https://read.qxmd.com/read/38507804/changes-in-anti-ov-16-igg4-responses-to-onchocerciasis-after-elimination-of-transmission-in-the-central-endemic-zone-of-guatemala
#10
JOURNAL ARTICLE
Vitaliano A Cama, Renata Mendizabal-Cabrera, Oscar de Leon, Michael White, Circe McDonald, Elizabeth Thiele, Guilherme M Ogawa, Zoraida Morales, Jessica Prince-Guerra, Paul Cantey, Nidia Rizzo
Current WHO guidelines for onchocerciasis elimination provide requirements for stopping mass drug administration of ivermectin and the verification of elimination of transmission. These guidelines also recommend post-elimination surveillance (PES) based on entomological surveys. Serological markers in humans could complement entomological PES once the longevity of anti-OV-16 antibody responses is better understood. In 2014-2015 we evaluated ELISA anti-OV-16 IgG4 antibody persistence among previously seropositive people from the central endemic zone of Guatemala...
March 19, 2024: American Journal of Tropical Medicine and Hygiene
https://read.qxmd.com/read/38506769/human-platelet-lysate-enhances-in-vivo-activity-of-car-v%C3%AE-2-t-cells-by-reducing-cellular-senescence-and-apoptosis
#11
JOURNAL ARTICLE
Feiyan Mo, Chiou-Tsun Tsai, Rong Zheng, Chonghui Cheng, Helen E Heslop, Malcolm K Brenner, Maksim Mamonkin, Norihiro Watanabe
BACKGROUND AIMS: Vγ9Vδ2 T cells are an attractive cell platform for the off-the-shelf cancer immunotherapy as the result of their lack of alloreactivity and inherent multi-pronged cytotoxicity, which could be further amplified with chimeric antigen receptors (CARs). In this study, we sought to enhance the in vivo longevity of CAR-Vδ2 T cells by modulating ex vivo manufacturing conditions and selecting an optimal CAR costimulatory domain. METHODS: Specifically, we compared the anti-tumor activity of Vδ2 T cells expressing anti-CD19 CARs with costimulatory endodomains derived from CD28, 4-1BB or CD27 and generated in either standard fetal bovine serum (FBS)- or human platelet lysate (HPL)-supplemented medium...
March 12, 2024: Cytotherapy
https://read.qxmd.com/read/38505776/applications-of-multiphoton-microscopy-in-imaging-cerebral-and-retinal-organoids
#12
REVIEW
Macit Emre Lacin, Murat Yildirim
Cerebral organoids, self-organizing structures with increased cellular diversity and longevity, have addressed shortcomings in mimicking human brain complexity and architecture. However, imaging intact organoids poses challenges due to size, cellular density, and light-scattering properties. Traditional one-photon microscopy faces limitations in resolution and contrast, especially for deep regions. Here, we first discuss the fundamentals of multiphoton microscopy (MPM) as a promising alternative, leveraging non-linear fluorophore excitation and longer wavelengths for improved imaging of live cerebral organoids...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38500550/aca-28-an-erk-mapk-signaling-modulator-exerts-anticancer-activity-through-ros-induction-in-melanoma-and-pancreatic-cancer-cells
#13
JOURNAL ARTICLE
Teruaki Takasaki, Yasuyuki Hamabe, Kenta Touchi, Golam Iftakhar Khandakar, Takeshi Ueda, Hitoshi Okada, Kazuko Sakai, Kazuto Nishio, Genzoh Tanabe, Reiko Sugiura
The extracellular signal-regulated kinase (ERK) MAPK pathway is dysregulated in various human cancers and is considered an attractive therapeutic target for cancer. Therefore, several inhibitors of this pathway are being developed, and some are already used in the clinic. We have previously identified an anticancer compound, ACA-28, with a unique property to preferentially induce ERK-dependent apoptosis in melanoma cells. To comprehensively understand the biological cellular impact induced by ACA-28, we performed a global gene expression analysis of human melanoma SK-MEL-28 cells exposed to ACA-28 using a DNA microarray...
2024: Oxidative Medicine and Cellular Longevity
https://read.qxmd.com/read/38499159/intermittent-fasting-and-longevity-from-animal-models-to-implication-for-humans
#14
REVIEW
Olha Strilbytska, Svitlana Klishch, Kenneth B Storey, Alexander Koliada, Oleh Lushchak
In recent years, intermittent fasting (IF) and its numerous modifications have been increasingly suggested as a promising therapy for age-related problems and a non-pharmacological strategy to extend lifespan. Despite the great variability in feeding schedules that we describe in the current work, underlying physiological processes are the same and include a periodic switch from glucose metabolism (generated by glycogenolysis) to fatty acids and fatty acid-derived ketones. Many of the beneficial effects of IF appear to be mediated by optimization of energy utilization...
March 16, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38497076/deciphering-aging-associated-molecular-mechanisms-in-bone-marrow-derived-hematopoietic-stem-cells-in-the-elderly-using-ngs-data
#15
JOURNAL ARTICLE
Hind A Alkhatabi
Aging is a complex process that is not yet fully understood. Despite advancements in research, a deeper understanding of the underlying biological mechanisms is necessary to develop interventions that promote healthy longevity. The aim of this study was to elucidate the complex mechanisms associated with healthy aging and longevity in healthy elderly individuals. The RNA sequencing (RNA-seq) data used in this study was obtained from the Gene Expression Omnibus (GEO) database (accession number GSE104406), which was collected from Fluorescent Activated Cell Sorting (FACS) of human bone marrow derived human hematopoietic stem cells (BM-HSCs) (Lineage-, CD34+, CD38-) young (18-30 years old) and aged (65-75 years old) donors who had no known hematological malignancy, with 10 biological replicates per group...
2024: Bioinformation
https://read.qxmd.com/read/38496317/how-are-apoe4-changes-in-body-weight-and-longevity-related-insights-from-a-causal-mediation-analysis
#16
JOURNAL ARTICLE
Rachel Holmes, Hongzhe Duan, Olivia Bagley, Deqing Wu, Yury Loika, Alexander Kulminski, Anatoliy Yashin, Konstantin Arbeev, Svetlana Ukraintseva
The ε4 allele of the APOE gene ( APOE4 ) is known for its negative association with human longevity; however, the mechanism is unclear. APOE4 is also linked to changes in body weight, and the latter changes were associated with survival in some studies. Here, we explore the role of aging changes in weight in the connection between APOE4 and longevity using the causal mediation analysis (CMA) approach to uncover the mechanisms of genetic associations. Using the Health and Retirement Study (HRS) data, we tested a hypothesis of whether the association of APOE4 with reduced survival to age 85+ is mediated by key characteristics of age trajectories of weight, such as the age at reaching peak values and the slope of the decline in weight afterward...
2024: Front Aging
https://read.qxmd.com/read/38490496/somatic-mutations-in-human-ageing-new-insights-from-dna-sequencing-and-inherited-mutations
#17
REVIEW
Kasit Chatsirisupachai, João Pedro de Magalhães
The accumulation of somatic mutations is a driver of cancer and has long been associated with ageing. Due to limitations in quantifying mutation burden with age in non-cancerous tissues, the impact of somatic mutations in other ageing phenotypes is unclear. Recent advances in DNA sequencing technologies have allowed the large-scale quantification of somatic mutations in ageing tissues. These studies have revealed a gradual accumulation of mutations in most normal tissues with age as well as a substantial clonal expansion driven mostly by cancer-related mutations...
March 13, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38484732/the-sirtuin-associated-human-senescence-program-converges-on-the-activation-of-placenta-specific-gene-pappa
#18
JOURNAL ARTICLE
Shijia Bi, Xiaoyu Jiang, Qianzhao Ji, Zehua Wang, Jie Ren, Si Wang, Yang Yu, Ruoqi Wang, Zunpeng Liu, Junhang Liu, Jianli Hu, Guoqiang Sun, Zeming Wu, Zhiqing Diao, Jingyi Li, Liang Sun, Juan Carlos Izpisua Belmonte, Weiqi Zhang, Guang-Hui Liu, Jing Qu
Sirtuins are pro-longevity genes with chromatin modulation potential, but how these properties are connected is not well understood. Here, we generated a panel of isogeneic human stem cell lines with SIRT1-SIRT7 knockouts and found that any sirtuin deficiency leads to accelerated cellular senescence. Through large-scale epigenomic analyses, we show how sirtuin deficiency alters genome organization and that genomic regions sensitive to sirtuin deficiency are preferentially enriched in active enhancers, thereby promoting interactions within topologically associated domains and the formation of de novo enhancer-promoter loops...
March 11, 2024: Developmental Cell
https://read.qxmd.com/read/38482892/neutrophil-to-lymphocyte-ratio-in-captive-olive-baboons-papio-anubis-the-effects-of-age-sex-rearing-stress-and-pregnancy
#19
JOURNAL ARTICLE
Sarah J Neal, Angela M Achorn, Steven J Schapiro, William D Hopkins, Joe H Simmons
In apes and humans, neutrophil to lymphocyte ratio (NLR) can be used as a predictive indicator of a variety of clinical conditions, longevity, and physiological stress. In chimpanzees specifically, NLR systematically varies with age, rearing, sex, and premature death, indicating that NLR may be a useful diagnostic tool in assessing primate health. To date, just one very recent study has investigated NLR in old world monkeys and found lower NLR in males and nursery-reared individuals, as well as a negative relationship between NLR and disease outcomes...
March 14, 2024: American Journal of Primatology
https://read.qxmd.com/read/38482194/mechanisms-of-endometrial-aging-lessons-from-natural-conceptions-and-assisted-reproductive-technology-cycles
#20
REVIEW
Anat Chemerinski, Jessica Garcia de Paredes, Kristin Blackledge, Nataki C Douglas, Sara S Morelli
Until recently, the study of age-related decline in fertility has focused primarily on the ovary; depletion of the finite pool of oocytes and increases in meiotic errors leading to oocyte aneuploidy are well-established mechanisms by which fertility declines with advancing age. Comparatively little is known about the impact of age on endometrial function. The endometrium is a complex tissue comprised of many cell types, including epithelial, stromal, vascular, immune and stem cells. The capacity of this tissue for rapid, cyclic regeneration is unique to this tissue, undergoing repeated cycles of growth and shedding (in the absence of an embryo) in response to ovarian hormones...
2024: Frontiers in Physiology
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