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https://www.readbyqxmd.com/read/27889699/comparison-of-clinical-factors-between-patients-with-angiotensin-converting-enzyme-inhibitor-induced-angioedema-and-cough
#1
Pär Hallberg, Julia Nagy, Malgorzata Karawajczyk, Leif Nordang, Gunilla Islander, Pia Norling, Hans-Erik Johansson, Mary Kämpe, Svante Hugosson, Qun-Ying Yue, Mia Wadelius
BACKGROUND: Angioedema is a rare and serious adverse drug reaction (ADR) to angiotensin-converting enzyme (ACE) inhibitor treatment. Dry cough is a common side effect of ACE inhibitors and has been identified as a possible risk factor for angioedema. OBJECTIVE: We compared characteristics between patients with ACE inhibitor-induced angioedema and cough with the aim of identifying risk factors that differ between these adverse events. METHODS: Data on patients with angioedema or cough induced by ACE inhibitors were collected from the Swedish database of spontaneously reported ADRs or from collaborating clinicians...
November 25, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27862587/are-non-allergic-drug-reactions-commonly-documented-as-medication-allergies-a-national-cohort-of-veterans-admissions-from-2000-to-2014
#2
Kevin W McConeghy, Aisling R Caffrey, Haley J Morrill, Amal N Trivedi, Kerry L LaPlante
PURPOSE: Adverse drug reactions (ADRs) including medication allergies are not well-described among large national cohorts. This study described the most common documented medication allergies and their reactions among a national cohort of Veterans Affairs (VA) inpatients. METHODS: We evaluated inpatient admissions in any VA Medical Center from 1 January 2000 to 31 December 2014. Each admission was linked with allergy history preceding or upon admission. Individual drugs were aggregated into drug class category including: penicillins, sulfonamides, angiotensin converting enzyme (ACE) inhibitors, opiates, HMG-CoA reductase inhibitors ("statins") and non-steroidal anti-inflammatory inhibitors (NSAID)...
November 13, 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/27754163/sy-11-3-hypertension-in-women-more-dangerous-than-in-men
#3
Suzanne Oparil
Heart disease, stroke, and kidney failure are leading causes of death worldwide, and hypertension is a significant risk factor for each. Hypertension is less common in women, compared to men, in those younger than 45 years of age. This trend is reversed in those 65 years and older. In the US between 2011-2014, the prevalence of hypertension in women and men by age group was 6% vs 8% (18-39 years), 30% vs 35% (40-59 years), and 67% vs 63% (60 years and over). Awareness, treatment, and control rates differ between genders with women being more aware of their diagnosis (85% vs 80%), more likely to take their medications (81% vs 71%) and more frequently having controlled hypertension (55% vs 49%)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753843/ed-01-1-are-arbs-comparable-to-aceis-in-patients-with-myocardial-infarction
#4
Chong-Jin Kim
With several lines of evidence, angiotensin-converting enzyme (ACE) inhibitors are recommended in patients with left ventricular systolic dysfunction or heart failure after myocardial infarction, and angiotensin receptor blockers (ARBs) are indicated in patients who are intolerant of ACE inhibitors. Up to 20% of patients cannot tolerate ACE inhibitors due to adverse reactions such as cough or angioedema, ARBs could be an alternative to ACE inhibitors. However, there is lack of data whether ARBs are comparable to ACE inhibitors in patients with myocardial infarction...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643118/sy-11-3-hypertension-in-women-more-dangerous-than-in-men
#5
Suzanne Oparil
Heart disease, stroke, and kidney failure are leading causes of death worldwide, and hypertension is a significant risk factor for each. Hypertension is less common in women, compared to men, in those younger than 45 years of age. This trend is reversed in those 65 years and older. In the US between 2011-2014, the prevalence of hypertension in women and men by age group was 6% vs 8% (18-39 years), 30% vs 35% (40-59 years), and 67% vs 63% (60 years and over). Awareness, treatment, and control rates differ between genders with women being more aware of their diagnosis (85% vs 80%), more likely to take their medications (81% vs 71%) and more frequently having controlled hypertension (55% vs 49%)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27642988/ed-01-1-are-arbs-comparable-to-aceis-in-patients-with-myocardial-infarction
#6
Chong-Jin Kim
With several lines of evidence, angiotensin-converting enzyme (ACE) inhibitors are recommended in patients with left ventricular systolic dysfunction or heart failure after myocardial infarction, and angiotensin receptor blockers (ARBs) are indicated in patients who are intolerant of ACE inhibitors. Up to 20% of patients cannot tolerate ACE inhibitors due to adverse reactions such as cough or angioedema, ARBs could be an alternative to ACE inhibitors. However, there is lack of data whether ARBs are comparable to ACE inhibitors in patients with myocardial infarction...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27614181/involvement-of-the-trpv1-receptor-in-plasma-extravasation-in-airways-of-rats-treated-with-an-angiotensin-converting-enzyme-inhibitor
#7
Janiana Raíza Jentsch Matias de Oliveira, Michel Fleith Otuki, Daniela Almeida Cabrini, Indiara Brusco, Sara Marchesan Oliveira, Juliano Ferreira, Eunice André
Angiotensin-converting enzyme inhibitors (ACEIs) are widely used in the treatment of hypertension, congestive heart failure and renal disease, and are considered relatively safe and generally well-tolerated drugs. However, adverse effects of ACEIs have been reported, including non-productive cough and angioedema, which can lead to poor adherence to therapy. The mechanisms by which ACEIs promote adverse effects are not fully elucidated, although increased bradykinin plasma levels following ACEI therapy seem to play an important role...
September 7, 2016: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27613994/ten-years-of-chronic-cough-in-a-64-year-old-man-with-multiple-pulmonary%C3%A2-nodules
#8
Whittney A Warren, Scott S Dalane, Bryce D Warren, Paul G Peterson, Rodney D Boyum, William Kelly
A 64-year-old male former smoker with a history of prostate cancer presented to our pulmonary clinic, complaining of nonproductive cough for 10 years. Prior evaluation included treatment for upper airway cough syndrome and gastroesophageal reflux, stopping angiotensin-converting enzyme inhibitor, and initiation of inhaled β-agonists. Esophageal pH monitoring indicated silent reflux, and proton pump inhibitor therapy was started. He continued to cough and complain of dyspnea. Physical examination produced unremarkable results, with no evidence of lymphadenopathy...
September 2016: Chest
https://www.readbyqxmd.com/read/27605525/the-role-of-microaspiration-in-the-pathogenesis-of-gastroesophageal-reflux-related-chronic-cough
#9
Pelin Özdemir, Münevver Erdinç, Rukiye Vardar, Ali Veral, Serdar Akyıldız, Özer Özdemir, Serhat Bor
Background/Aims: Gastroesophageal reflux disease (GERD) is one of the main causes of chronic cough. We evaluated the role of microaspiration in the pathogenesis of reflux-related cough by determining the amount of lipid-laden macrophages in bronchoalveolar lavage specimens. Methods: A total of 161 cases of chronic cough were evaluated, and 36 patients (average age 48.2 years) were recruited for this single center prospective study. Patients with a history of smoking, angiotensin converting enzyme inhibitor usage, any abnormality on pulmonary function tests, abnormal chest X-ray, occupational or environmental exposures, or upper airway cough syndrome were excluded...
September 8, 2016: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/27542423/evidence-based-evaluation-and-management-of-chronic-cough
#10
REVIEW
Andreas Achilleos
Chronic cough is common and has a significant impact on the wellbeing of patients and the use and cost of health care services. Traditionally the approach to chronic cough in patients who are nonsmokers and are not taking an angiotensin-converting enzyme inhibitor has focused on the diagnosis and management of the upper airway cough syndrome, asthma, and reflux disease. The evaluation of patients with chronic cough frequently involves trials of empiric therapy for these 3 conditions. Chronic cough may be perpetuated by abnormalities of the cough reflex and sensitization of its afferent and central components...
September 2016: Medical Clinics of North America
https://www.readbyqxmd.com/read/27468462/captopril-augments-acetylcholine-induced-bronchial-smooth-muscle-contractions-in-vitro-via-kinin-dependent-mechanisms
#11
Naman Agrawal, Aparna Akella, Shripad B Deshpande
Angiotensin converting enzyme (ACE) inhibitors therapy is aassociated with bothersome dry cough as an adverse effect. The mechanisms underlying this adverse effect are not clear. Therefore, influence of captopril (an ACE inhibitor) on acetylcholine (ACh)-induced bronchial smooth muscle contractions was investigated. Further, the mechanisms underlying the captopril-induced changes were also explored. In vitro contractions of rat bronchial smooth muscle to cumulative concentrations of ACh were recorded before and after exposure to captopril...
June 2016: Indian Journal of Experimental Biology
https://www.readbyqxmd.com/read/27377659/protection-against-death-and-renal-failure-by-renin-angiotensin-system-blockers-in-patients-with-diabetes-and-kidney-disease
#12
Jian Shen, Yan-Mei Huang, Xin-Nan Song, Xue-Zhi Hong, Min Wang, Wei Ling, Xiao-Xi Zhang, Hai-Lu Zhao
INTRODUCTION: Angiotensin-converting enzyme inhibitors (ACEis) and angiotensin receptor blockers (ARBs) are widely used to block the renin-angiotensin system (RAS). Yet it remains uncertain whether these drugs are equally effective and safe. METHODS: Systematic reviews and meta-analyses of ACEis/ARBs in diabetes and kidney disease published in PubMed, Chinese National Knowledge Infrastructure (CNKI) and Wanfang databases were searched for clinical outcomes including all-cause mortality, end-stage renal disease (ESRD), hyperkalemia and cough...
July 2016: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://www.readbyqxmd.com/read/27335175/benazepril-induced-agranulocytosis-a-case-report-and-review-of-the-literature
#13
Hafiz Rizwan Talib Hashmi, Rami Jabbour, Zwi Schreiber, Misbahuddin Khaja
BACKGROUND: Angiotensin-converting enzyme inhibitors are widely used drugs, and in appropriately selected patients, serious side effects are infrequent. Commonly seen side effects include cough, rash, hyperkalemia, renal dysfunction, and angioedema. Historically, dose-related agranulocytosis has been associated with captopril. Benazepril, a relatively more potent angiotensin-converting enzyme inhibitor, is rarely associated with agranulocytosis. CASE REPORT: Here, we report a case of drug-induced agranulocytosis due to benazepril, with complete recovery of white blood cell count upon discontinuation of the drug...
2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27271577/eriobotrya-japonica-water-extract-characterization-an-inducer-of-interferon-gamma-production-mainly-by-the-jak-stat-pathway
#14
Khalid Z Matalka, Nada A Abdulridha, Mujtaba M Badr, Kenza Mansoor, Nidal A Qinna, Fadi Qadan
Eriobotrya japonica (Thunb.) Lindl. (Loquat) (EJ) has been used as a medicinal plant to treat chronic bronchitis, coughs, phlegm, high fever and gastro-enteric disorders. Since the traditional use of EJ is related to modulating inflammation processes, our earlier studies on EJ leaves were performed on the water extract to investigate specific cytokines' modulation. These earlier studies, however, have shown that EJ leaf water extract (WE) and the water phase (WP) induce cytokines' production in in vitro and in vivo models...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27112942/health-outcomes-and-economic-consequences-of-using-angiotensin-converting-enzyme-inhibitors-in-comparison-with-angiotensin-receptor-blockers-in-the-treatment-of-arterial-hypertension-in-the-contemporary-polish-setting
#15
Witold Wrona, Katarzyna Budka, Krzysztof J Filipiak, Maciej Niewada, Bogdan Wojtyniak, Tomasz Zdrojewski
BACKGROUND: Arterial hypertension (AH) represents a public health problem in Poland, firstly due to the huge, still growing population of patients (10.45 million patients based on NATPOL 2011 and PolSenior Surveys), and secondly because of the substantial cost of reimbursement from the National Health Fund (NHF). The most commonly used drugs in the treatment of AH include angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), the latter being associated with significantly higher unit reimbursement cost...
2016: Kardiologia Polska
https://www.readbyqxmd.com/read/27001591/optimizing-treatment-risk-and-benefit-for-elderly-patients-with-advanced-non-small-cell-lung-cancer-the-right-treatment-for-the-right-patient
#16
COMMENT
Carolyn J Presley, Cary P Gross, Rogerio C Lilenbaum
The Oncology Grand Rounds series is designed to place original reports published in theJournal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published inJournal of Clinical Oncology, to patients seen in their own clinical practice...
May 1, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/26937758/chronic-cough-and-a-normal-chest-x-ray-a-simple-systematic-approach-to-exclude-common-causes-before-referral-to-secondary-care-a-retrospective-cohort-study
#17
Richard D Turner, Graham H Bothamley
Chronic cough is common in the community and can cause significant morbidity. It is not clear how closely treatment guidelines are used in general practice, or how often specialist referral is indicated. We aimed to assess the management of chronic cough in primary care before referral to a cough clinic, and to assess the outcome of managing chronic cough with an approach of simple investigation and empirical treatment trials. Data were extracted from the records of all patients attending a district general hospital respiratory clinic over a two-year period with isolated chronic cough lasting ⩾8 weeks...
2016: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/26892615/approaching-chronic-cough
#18
Vijo Poulose, Pei Yee Tiew, Choon How How
Chronic cough is one of the most common reasons for referral to a respiratory physician. Although fatal complications are rare, it may cause considerable distress in the patient's daily life. Western and local data shows that in patients with a normal chest radiograph, the most common causes are postnasal drip syndrome, postinfectious cough, gastro-oesophageal reflux disease and cough variant asthma. Less common causes are the use of angiotensin-converting enzyme inhibitors, smoker's cough and nonasthmatic eosinophilic bronchitis...
February 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/26860956/comparison-of-diagnostic-evaluations-for-cough-among-initiators-of-angiotensin-converting-enzyme-inhibitors-and-angiotensin-receptor-blockers
#19
Mugdha Gokhale, Cynthia Girman, Yong Chen, Virginia Pate, Michele Jonsson Funk, Til Stürmer
PURPOSE: Differential diagnostic evaluation associated with a drug may bias effect estimates because of an increased detection of preclinical outcomes. Persistent cough is a common side effect with angiotensin-converting enzyme inhibitors (ACEI), and we hypothesized that ACEI initiators would undergo more diagnostic evaluations, potentially leading to diagnosis of preclinical lung cancer. We compared the incidence of cough-related diagnostic evaluations and lung cancer among ACEI versus angiotensin receptor blockers (ARB) initiators...
May 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/26827596/-aural-stimulation-with-capsaicin-ointment-improved-the-swallowing-function-in-patients-with-dysphagia-evaluation-by-the-smrc-scale
#20
Eiji Kondo, Osamu Jinnouchi, Hiroki Ohnishi, Ikuji Kawata, Noriaki Takeda
Cough and swallowing reflexes are important airway-protective mechanisms against aspiration. Angiotensin-converting enzyme (ACE) inhibitors, one of the side effects of which is cough, have been reported to reduce the incidence of aspiration pneumonia in hypertensive patients with stroke. ACE inhibitors have also been reported to improve the swallowing function in post-stroke patients. On the other hand, stimulation of the Arnold nerve, the auricular branch of the vagus, triggers the cough reflex (Arnold's ear-cough reflex)...
November 2015: Nihon Jibiinkoka Gakkai Kaiho
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