keyword
https://read.qxmd.com/read/38319354/-chronic-cough-in-adult-patients-evidence-based-approach
#1
JOURNAL ARTICLE
Karen Krüger, Felix Holzinger
Approximately 10% of the population suffer from a cough lasting longer than 8 weeks. Compared to acute cough, which usually occurs in the context of banal respiratory tract infections, the differential diagnoses of chronic cough require an increased use of diagnostic tests and thus a structured, evidence-based approach according to current international guidelines. A targeted history (smoking status, medication, previous diseases) and ENT status are always followed by chest x‑ray and pulmonary function tests before extended diagnostics...
February 6, 2024: HNO
https://read.qxmd.com/read/38263021/comparison-of-two-single-pill-dual-combination-antihypertensive-therapies-in-chinese-patients-a-randomized-controlled-trial
#2
RANDOMIZED CONTROLLED TRIAL
Qi-Fang Huang, Di Zhang, Yihong Luo, Kun Hu, Qiong Wu, Hailong Qiu, Fei Xu, Mei-Ling Wang, Xin Chen, Yan Li, Ji-Guang Wang
BACKGROUND: Current hypertension guidelines recommend combination of an angiotensin-converting enzyme inhibitor or angiotensin-receptor blocker with a calcium-channel blocker or thiazide diuretic as initial antihypertensive therapy in patients with monotherapy uncontrolled hypertension. However, to what extent these two different combinations are comparable in blood pressure (BP)-lowering efficacy and safety remains under investigation, especially in the Chinese population. We investigated the BP-lowering efficacy and safety of the amlodipine/benazepril and benazepril/hydrochlorothiazide dual therapies in Chinese patients...
January 24, 2024: BMC Medicine
https://read.qxmd.com/read/38108069/antihypertensives-associated-adverse-events-a-review-of-mechanisms-and-pharmacogenomic-biomarkers-available-evidence-in-multi-ethnic-populations
#3
REVIEW
Sahar M Altoum, Zeina N Al-Mahayri, Bassam R Ali
Hypertension remains a significant health burden worldwide, re-emphasizing the outstanding need for more effective and safer antihypertensive therapeutic approaches. Genetic variation contributes significantly to interindividual variability in treatment response and adverse events, suggesting pharmacogenomics as a major approach to optimize such therapy. This review examines the molecular mechanisms underlying antihypertensives-associated adverse events and surveys existing research on pharmacogenomic biomarkers associated with these events...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/38096024/identifying-existing-evidence-to-potentially-develop-a-machine-learning-diagnostic-algorithm-for-cough-in-primary-care-settings-scoping-review
#4
REVIEW
Julia Cummerow, Christin Wienecke, Nicola Engler, Philip Marahrens, Philipp Gruening, Jost Steinhäuser
BACKGROUND: Primary care is known to be one of the most complex health care settings because of the high number of theoretically possible diagnoses. Therefore, the process of clinical decision-making in primary care includes complex analytical and nonanalytical factors such as gut feelings and dealing with uncertainties. Artificial intelligence is also mandated to offer support in finding valid diagnoses. Nevertheless, to translate some aspects of what occurs during a consultation into a machine-based diagnostic algorithm, the probabilities for the underlying diagnoses (odds ratios) need to be determined...
December 14, 2023: Journal of Medical Internet Research
https://read.qxmd.com/read/37995049/patient-reported-reasons-for-antihypertensive-medication-change-a-quantitative-study-using-social-media
#5
JOURNAL ARTICLE
Cristina Micale, Su Golder, Karen O'Connor, Davy Weissenbacher, Robert Gross, Sean Hennessy, Graciela Gonzalez-Hernandez
INTRODUCTION: Hypertension is the leading cause of heart disease in the world, and discontinuation or nonadherence of antihypertensive medication constitutes a significant global health concern. Patients with hypertension have high rates of medication nonadherence. Studies of reasons for nonadherence using traditional surveys are limited, can be expensive, and suffer from response, white-coat, and recall biases. Mining relevant posts by patients on social media is inexpensive and less impacted by the pressures and biases of formal surveys, which may provide direct insights into factors that lead to non-compliance with antihypertensive medication...
November 23, 2023: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://read.qxmd.com/read/37919844/evaluation-and-management-of-chronic-cough-in-adults
#6
JOURNAL ARTICLE
Dana V Wallace
Background: Chronic cough (CC), a cough that lasts > 8 weeks, has an overall prevalence of 5-11% in adults, peaking between 60 and 80 years of age. Of the 15% of patients who remain undiagnosed or refractory to treatment, two thirds are women. Objective: The objective was to present an updated evidence-based algorithmic approach for evaluating and managing CC, with emphasis on treatment modalities for refractory CC. Methods: A literature search was conducted of medical literature data bases for guidelines, position papers, systematic reviews, and clinical trials from January 2022 to June 2023, on the evaluation and management of CC...
November 1, 2023: Allergy and Asthma Proceedings:
https://read.qxmd.com/read/37805878/management-of-risks-of-adverse-drug-reactions-according-to-adr-report-form-data-from-lviv-region-healthcare-facilities-in-2022
#7
JOURNAL ARTICLE
N Stepaniuk, O Piniazhko, O Poshyvak, T Bessarab, N Hudz, I Gavriluk
The study aimed to analyse the adverse drug reactions report form data received by the State Expert Center of the Ministry of Health of Ukraine from healthcare professionals in the Lviv region in 2022. Regarding specific types of medicines, the ones with proven cause-and-effect relationships that caused the highest frequency of adverse drug reactions incidents were chemotherapeutic agents (35.5%), medicines affecting the cardiovascular system (20.3%), and non-steroidal anti-inflammatory drugs (8%). Within the penicillin class, amoxicillin potentiated by clavulanate (67%) and amoxicillin (29%) were the dominant drugs showing the highest incidence rate of adverse reactions...
2023: Georgian Medical News
https://read.qxmd.com/read/37799968/association-between-angiotensin-converting-enzyme-inhibitor-induced-cough-and-the-risk-of-lung-cancer-a-mendelian-randomization-study
#8
JOURNAL ARTICLE
Taikang Yao, Zhenchao Wu, Zilu Wang, Liting Chen, Beibei Liu, Ming Lu, Ning Shen
Background: Observational studies and meta-analyses have demonstrated a positive correlation between the use of angiotensin-converting enzyme inhibitors (ACEIs) and lung cancer. However, the findings remain controversial; furthermore, the relationship between ACEI-induced cough and lung cancer development remains unknown. We used Mendelian randomization (MR) to verify the association between ACEI use, ACEI-induced cough, and the risk of lung cancer. Methods: We performed a two-sample MR analysis to determine the unconfounded relationships between ACE inhibition, which mimics the effects of ACEIs, and genetic proxies for ACEI-induced cough and lung cancer...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37744527/life-threatening-bronchospasm-induced-by-an-angiotensin-converting-enzyme-inhibitor-in-a-chronically-ventilated-patient-diagnostic-pitfalls-and-literature-review
#9
Esther-Lee Marcus, Amir Hush, Hisham Atrash, Roaia Shibli, Samuel N Heyman
Cough- and asthma-like symptoms are common adverse reactions to angiotensin-converting enzyme inhibitors (ACEi). However, attributing these symptoms to the use of ACEi might be masked by clinical confounders. We report a 68-year-old female residing in a long-term acute-care facility for patients requiring prolonged invasive mechanical ventilation treated for years with ACEi. Daily reversible bouts of life-threatening severe bronchospasm gradually developed over 6 weeks and abruptly resolved following the cessation of ACEi treatment...
October 2023: Respirology Case Reports
https://read.qxmd.com/read/37727676/cardiomyopathy-as-cause-of-death-in-duchenne-muscular-dystrophy-a-longitudinal-observational-study
#10
JOURNAL ARTICLE
Annabel Lechner, Joël J Herzig, Jacqueline G Kientsch, Malcolm Kohler, Konrad E Bloch, Silvia Ulrich, Esther I Schwarz
BACKGROUND: Cardiomyopathy has become an important life-limiting factor since survival in Duchenne muscular dystrophy (DMD) has greatly increased with long-term ventilation and cough assistance. The aim of this study was to investigate the association between impaired left ventricular ejection fraction (LVEF) and survival. METHODS: In a >20-year observational study in patients with DMD (age ≥16 years) with at least three echocardiograms, the association between LVEF and survival and time to cardiac or non-cardiac death was investigated using Kaplan-Meier survival analysis and Cox regression (for LVEF)...
September 2023: ERJ Open Research
https://read.qxmd.com/read/37602458/a-randomized-trial-of-genotype-guided-perindopril-use
#11
JOURNAL ARTICLE
Sang-Hak Lee, Chan Joo Lee, Yura Kang, Jung Mi Park, Ji Hyun Lee
OBJECTIVE: Cough caused by angiotensin-converting enzyme inhibitors (ACEIs) limits their clinical application and cardiovascular benefits. This randomized trial investigated whether genotype-guided perindopril use could reduce drug-related cough in 20 to 79-year-old individuals with hypertension. METHODS: After screening 120 patients and randomization, 68 were assigned to genotyping (n = 41) and control (n = 27) groups. NELL1 p.Arg382Trp (rs8176786) and intron (rs10766756) genotype information was used to subdivide the genotyping group into high-risk and low-risk subgroups with at least one or no risk alleles for ACEI-related cough, respectively...
August 15, 2023: Journal of Hypertension
https://read.qxmd.com/read/37417783/angiotensin-converting-enzyme-inhibitor-induced-cough-compared-with-placebo-and-other-antihypertensives-a-systematic-review-and-network-meta-analysis
#12
JOURNAL ARTICLE
Yiyun Hu, Ling Liang, Shuang Liu, Janice Y Kung, Hoan Linh Banh
Studies have shown that angiotensin converting enzyme inhibitors (ACEIs) are superior in primary and secondary prevention for cardiac mortality and morbidity to angiotensin receptor blocker (ARBs). One of the common side effects from ACEI is dry cough. The aims of this systematic review, and network meta-analysis are to rank the risk of cough induced by different ACEIs and between ACEI and placebo, ARB or calcium channel blockers (CCB). We performed a systematic review, and network meta-analysis of randomized controlled trials to rank the risk of cough induced by each ACEI and between ACEI and placebo, ARB or CCB...
August 2023: Journal of Clinical Hypertension
https://read.qxmd.com/read/37354675/nitrosogenesis-of-skin-human-cancer-the-hidden-truth-of-a-neverending-story-nitrosamine-contamination-in-olmesartan-valsartan-and-hct-as-main-risk-factor-for-the-development-of-keratinocyte-cancer
#13
JOURNAL ARTICLE
G Tchernev, S Kordeva
The pathogenesis of skin cancer remains shrouded in mystery. Nevertheless, a substantial amount of new data is now available to provide a logical explanation regarding the possible link between 1) the occurrence of single or multiple acquired/somatic mutations and 2) the generation and progression of skin cancer, as well as 3) the potential association of the above two facts with the availability of nitrosamines in drugs for hypertension, diabetes, gastritis, acne, tuberculosis, various other antibiotics, etc...
April 2023: Georgian Medical News
https://read.qxmd.com/read/37299008/is-it-still-relevant-to-discover-new-ace-inhibitors-from-natural-products-yes-but-only-with-comprehensive-approaches-to-address-the-patients-real-problems-chronic-dry-cough-and-angioedema
#14
REVIEW
Sivananthan Manoharan
Despite many publications related to the identification of new angiotensin-I-converting enzyme (ACE) inhibitors, especially peptides from natural products, the actual reason/s for why new ACE inhibitors need to be discovered are yet to be fully understood. New ACE inhibitors are pivotal to address serious side effects caused by commercially available ACE inhibitors in hypertensive patients. Despite the effectiveness of commercial ACE inhibitors, due to these side effects, doctors often prescribe angiotensin receptor blockers (ARBs)...
June 2, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/37284934/ace-inhibitors-in-hypertension-a-historical-perspective-and-current-insights
#15
REVIEW
Stacey Cutrell, Ibrahim S Alhomoud, Anurag Mehta, Azita H Talasaz, Benjamin Van Tassell, Dave L Dixon
PURPOSE OF REVIEW: This review describes the discovery and development of ACE inhibitors as antihypertensive agents, compares their efficacy, tolerability, and safety to ARBs, and highlights the contemporary issues surrounding ACE inhibitor use for HTN. RECENT FINDINGS: Angiotensin-converting enzyme (ACE) inhibitors are commonly prescribed medications for the management of hypertension (HTN) and other chronic conditions including heart failure and chronic kidney disease...
September 2023: Current Hypertension Reports
https://read.qxmd.com/read/37231800/documented-adverse-drug-reactions-and-discontinuation-of-angiotensin-converting-enzyme-inhibitors-and-angiotensin-receptor-blockers-in-chronic-kidney-disease
#16
JOURNAL ARTICLE
L Parker Gregg, Peter A Richardson, Michael A Herrera, Julia M Akeroyd, Shehrezade A Jafry, Glenn T Gobbel, Sheena Wydermyer, Jennifer Arney, Adriana Hung, Michael E Matheny, Salim S Virani, Sankar D Navaneethan
INTRODUCTION: Angiotensin-converting enzyme inhibitors (ACEis) and angiotensin receptor blockers (ARBs) are frequently discontinued in patients with chronic kidney disease (CKD). Documented adverse drug reactions (ADRs) in medical records may provide insight into the reasons for treatment discontinuation. METHODS: In this retrospective cohort of US veterans from 2005 to 2019, we identified individuals with CKD and a current prescription for an ACEi or ARB (current user group) or a discontinued prescription within the preceding 5 years (discontinued group)...
2023: American Journal of Nephrology
https://read.qxmd.com/read/37201212/pharmacogenetic-predictors-of-development-of-secondary-to-enalapril-dry-cough-in-hypertensive-patients
#17
JOURNAL ARTICLE
Ivan V Sychev, Natalia P Denisenko, Anastasiya A Kachanova, Anna V Lapshtaeva, Ludmila N Goncharova, Karin B Mirzaev, Dmitry A Sychev
OBJECTIVES: Development of the secondary to ACEI cough leads to discontinuation of the drugs of this group. Assessing the safety of the ACEIs with further development of customized approaches for their administration is a major scientific and practical problem. The objective of this study was to assess the association of the genetic markers with the development of the adverse drug reaction in the form of secondary to enalapril dry cough in the patients with essential arterial hypertension...
May 19, 2023: Drug Metabolism and Personalized Therapy
https://read.qxmd.com/read/36628825/pathophysiology-of-cough-with-angiotensin-converting-enzyme-inhibitors-how-to-explain-within-class-differences
#18
REVIEW
Claudio Borghi, Arrigo Fg Cicero, Davide Agnoletti, Giulia Fiorini
Angiotensin converting enzyme inhibitors (ACEi) have consistently demonstrated improved survival and reduced risk of major cardiovascular events, across the spectrum of cardiovascular disease, including hypertension, coronary artery disease, myocardial infarction, and heart failure. The cardioprotective effects of ACEi result from inhibiting the conversion of angiotensin I to angiotensin II, and inhibition of bradykinin degradation. They are generally well tolerated but may cause the onset of a dry cough in some patients...
April 2023: European Journal of Internal Medicine
https://read.qxmd.com/read/36550001/effect-of-behavioral-cough-suppression-therapy-delivered-via-telehealth
#19
JOURNAL ARTICLE
Nathaniel Sundholm, Sandeep Shelly, Miranda L Wright, Jane Reynolds, Laurie Slovarp, Amanda I Gillespie
OBJECTIVES/HYPOTHESIS: Behavioral cough suppression therapy (BCST) has demonstrated up to 88% effectiveness at treating refractory chronic cough (RCC). With onset of the COVID-19 pandemic, along with many other medical services, BCST shifted to telehealth delivery. Our group hypothesized that BCST delivered via telemedicine by a specialized Speech-Language Pathologist would be comparable to previously reported response to treatment for in-person settings. STUDY DESIGN: Retrospective review...
December 20, 2022: Journal of Voice
https://read.qxmd.com/read/36540485/angiotensin-converting-enzyme-inhibitor-induced-angioedema-following-posterior-reversible-encephalopathy-syndrome-in-a-child-a-case-report
#20
Kanami Ichikawa, Daisuke Matsuoka, Tsubasa Murase, Yozo Nakazawa
Angioedema is a rare but potentially lethal side effect of angiotensin-converting enzyme inhibitors (ACEIs). Most ACEI-induced angioedema (ACEI-AE) cases have been reported in adults, with few reports of cases in children. Posterior reversible encephalopathy syndrome (PRES) is a neurological disorder that presents with acute onset of symptoms, including headache, vomiting, visual disturbances, and seizures. We report the case of a patient who developed ACEI-AE after developing PRES during the treatment of steroid-resistant nephrotic syndrome...
November 2022: Curēus
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