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Apigenin

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https://www.readbyqxmd.com/read/29034071/apigenin-in-cancer-therapy-anti-cancer-effects-and-mechanisms-of-action
#1
REVIEW
Xiaohui Yan, Miao Qi, Pengfei Li, Yihong Zhan, Huanjie Shao
Apigenin is a common dietary flavonoid that is abundantly present in many fruits, vegetables and Chinese medicinal herbs and serves multiple physiological functions, such as strong anti-inflammatory, antioxidant, antibacterial and antiviral activities and blood pressure reduction. Therefore, apigenin has been used as a traditional medicine for centuries. Recently, apigenin has been widely investigated for its anti-cancer activities and low toxicity. Apigenin was reported to suppress various human cancers in vitro and in vivo by multiple biological effects, such as triggering cell apoptosis and autophagy, inducing cell cycle arrest, suppressing cell migration and invasion, and stimulating an immune response...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/29023064/impact-of-zeatin-and-thidiazuron-on-phenols-and-flavonoids-accumulation-in-callus-cultures-of-gardenia-gardenia-jasminoides
#2
Ahmed Mohamed Magdy Gabr, Nermeen Mohamed Arafa, Amal Abd El-Latif El-Ashry, Mohamed Kamal El-Bahr
BACKGROUND AND OBJECTIVE: Gardenia (Gardenia jasminoides) has many pharmacological actions such as anti-inflammatory, antioxidant and fibrolytic activities and cytotoxic effects, etc. This study was conducted to recognize the effect of zeatin and thidiazuron (TDZ) on callus proliferation, total phenolic content, total flavonoids and DPPH scavenging activity of gardenia callus cultures. MATERIALS AND METHODS: Calli were cultured on Murashige and Skoog (MS) medium supplement with different concentrations (2, 4 or 6 mg L-1) of zeatin or TDZ individually as well as combination of 2 mg L-1 zeatin+4 mg L-1 TDZ...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/29022496/antitumor-and-radiosensitizing-synergistic-effects-of-apigenin-and-cryptotanshinone-against-solid-ehrlich-carcinoma-in-female-mice
#3
Amina M Medhat, Khaled Sh Azab, Mahmoud M Said, Neama M El Fatih, Nermeen M El Bakary
Considerable attention has been paid to the introduction of novel naturally occurring plant-derived radiosensitizer compounds in order to augment the radiation efficacy and improve the treatment outcome of different tumors. This study was therefore undertaken to evaluate the antitumor, antiangiogeneic, and synergistic radiosensitizing effects of apigenin, a dietary flavonoid, and/or cryptotanshinone, a terpenoid isolated from the roots of Salvia miltiorrhiza, against the growth of solid Ehrlich carcinoma in female mice...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28987377/analysis-of-bioactive-constituents-from-the-leaves-of-amorpha-fruticosa-l
#4
Xueqin Cui, Jing Guo, Ching-Shu Lai, Min-Hsiung Pan, Zhongxiao Ma, Sen Guo, Qingchao Liu, Li Zhang, Chi-Tang Ho, Naisheng Bai
Amorpha fruticosa L. is a Chinese folk medicine and rich in polyphenols. Fifteen known compounds were isolated and identified from the leaves of A. fruticosa L. They are tephrosin (1), 6a,12a-dehydrodeguelin (2), vitexin (3), afrormosin-7-O-β-d-glucopyranoside (4), 2″-O-α-l-rhamnopyranosyl isovitexin (5), rutin (6), chrysoeriol (7), 7-O-methylluteolin (8), trans-p-coumaric acid (9), 2-benzyl-4,6-dihydroxybenzoic acid-4-O-β-d-glucopyranoside (10), formononetin (11), quercetin (12), apigenin (13), β-sitosterol (14), and β-daucosterol (15)...
October 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28987371/morphological-and-chemical-analyses-of-eriocauli-flos-sold-in-taiwan-markets
#5
I-Jung Lee, Cheng-Pei Chung, Shu-Jen Chang, Yun-Lian Lin
Eriocauli Flos (Gujingcao; EF), the dried capitulum with the peduncle of Eriocaulon buergerianum Koern. (Eriocaulaceae), is a Chinese herbal medicine for treating eye diseases and inflammation. However, several species of the Eriocaulon genus are used as substitutes in different areas. To examine the species of EF used in Taiwan and to establish the quality control platform, morphological and chemical analyses have been performed. Ten major compounds, including apigenin (7) and its 7-O-β-D-glucopyranoside (1) and 7-O-(6-O-E-coumaroyl)-β-D-glucopyranoside (6), hispidulin (8) and its 7-O-β-D-glucopyranoside (2) and 7-O-(6-O-E-coumaroyl)-β-D-glucopyranoside (5), jaceosidin (9) and its 7-O-β-D-glucopyranoside (3), and toralactone (10) and its 9-O-β-D-glucopyranosyl(1→6)-β-D-glucopyranoside (4), were isolated and identified from commercially available EF...
October 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28985183/the-effect-of-celery-apium-graveolens-l-on-fertility-a-systematic-review
#6
Wesam Kooti, Maryam Moradi, Khadijeh Peyro, Maedeh Sharghi, Fatima Alamiri, Milad Azami, Mohammad Firoozbakht, Mehri Ghafourian
Background Fertility and infertility problems are among the complex issues in medicine. The use of herbal products in the treatment of fertility has been considered as an alternative to synthetic drugs. Celery containing known compounds can have an impact on the fertility rate. The aim of this study was to do a systematic review on conducted studies in conjunction with the celery and reproduction. Methods Required papers were searched from databases like Science direct, PubMed, Scopus, and Springer. Keywords used in this study were "Apium graveolens L...
October 6, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28983983/flavonoid-constituents-of-phlomis-lamiaceae-species-using-liquid-chromatography-mass-spectrometry
#7
Fatemeh Aghakhani, Navaz Kharazin, Zahra Lori Gooini
INTRODUCTION: Phlomis is one of the medicinal genera of Lamiaceae. This genus has unique medicinal properties. Consequently, appropriate methods need to be described for the identification of the chemical compounds. OBJECTIVE: A liquid chromatography tandem mass spectrometry (LC-MS/MS) technique on a triple quadrupole mass spectrometer (TQMS) was used for separation and identification of leaf flavonoid compounds for seven Phlomis species including Phlomis kurdia, Ph...
October 5, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28977348/isolation-of-flavonoids-from-wild-aquilaria-sinensis-leaves-by-an-improved-preparative-high-speed-counter-current-chromatography-apparatus
#8
Mao-Xun Yang, Yao-Guang Liang, He-Ru Chen, Yong-Fang Huang, Hai-Guang Gong, Tian-You Zhang, Yoichiro Ito
Four flavonoids including apigenin-7,4'-dimethylether, genkwanin, quercetin, and kaempferol were isolated in a preparative or semi-preparative scale from the leaves of wild Aquilaria sinensis using an improved preparative high-speed counter-current chromatography apparatus. The separations were performed with a two-phase solvent system composed of hexane-ethyl acetate, methanol-water at suitable volume ratios. The obtained fractions were analyzed by HPLC, and the identification of each target compound was carried out by ESI-MS and NMR...
September 5, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28972678/antioxidant-anti-inflammatory-and-enzyme-inhibitory-activity-of-natural-plant-flavonoids-and-their-synthesized-derivatives
#9
Shivraj Hariram Nile, Young Soo Keum, Arti Shivraj Nile, Shivkumar S Jalde, Rahul V Patel
The synthesized flavonoid derivatives were examined for their antioxidant, anti-inflammatory, xanthine oxidase (XO), urease inhibitory activity, and cytotoxicity. Except few, all the flavonoids under this study showed significant antioxidant activity (45.6%-85.5%, 32.6%-70.6%, and 24.9%-65.5% inhibition by DPPH, ferric reducing/antioxidant power, and oxygen radical absorption capacity assays) with promising TNF-α inhibitory activity (42%-73% at 10 μM) and IL-6 inhibitory activity (54%-81% at 10 μM) compared with that of control dexamethasone...
October 3, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28971573/apigenin-ameliorates-the-obesity-induced-skeletal-muscle-atrophy-by-attenuating-mitochondrial-dysfunction-in-the-muscle-of-obese-mice
#10
Won Hee Choi, Hyo Jeong Son, Young Jin Jang, Jiyun Ahn, Chang Hwa Jung, Tae Youl Ha
SCOPE: We investigated whether apigenin protected against skeletal muscle atrophy induced by obesity. METHODS AND RESULTS: Mice were fed a high fat diet (HFD) for 9 wks to induce obesity, and then were assigned to two groups; the HFD group received a high fat diet, and the HFD+AP group received a 0.1% apigenin-containing HFD. After additional feeding of the experimental diet for 8 wks, mice in the HFD group were highly obese compared with the mice in the standard diet fed mice group...
October 2, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28964373/phenolic-composition-profiling-of-different-edible-parts-and-by-products-of-date-palm-phoenix-dactylifera-l-by-using-hplc-dad-esi-ms-n
#11
Ibrahim M Abu-Reidah, Ángel Gil-Izquierdo, Sonia Medina, Federico Ferreres
Fruits and vegetables are an important source of dietary antioxidants and epidemiological studies show that their regular intake in the diet may decrease the risk of several chronic diseases. Phoenix dactylifera L. (date palm or dates) is an important crop, widely used in the Arabian region and in other parts of the world as a food and also in folk medicine, due to its health-promoting properties. Antioxidant phytochemicals present in plant foods are partly responsible for such health benefits. The antioxidants present in dates are mainly phenolics, like flavonoids and phenolic acids...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28963002/protective-effects-of-apigenin-against-acrylonitrile-induced-subchronic-sperm-injury-in-rats
#12
Yuhui Dang, Zhilan Li, Boyan Luo, Li Pan, Qian Wei, Yinmei Zhang
This study aimed to investigate the protective effects of apigenin (AP), a flavonoid found in plants, against acrylonitrile (ACN)-induced subchronic sperm and testes injury in rats. Male Sprague-Dawley rats were randomly divided into four groups: a control group (corn oil), an ACN group (ACN 50 mg kg(-1)), an ACN + AP1 group (ACN + AP 234 mg kg(-1)), and an ACN + AP2 group (ACN + AP 468 mg kg(-1)). The ACN + AP group received AP by gavage after treatment with 50 mg kg(-1) ACN for 30 min, whereas the rats in the control group were given an equivalent volume of corn oil...
September 28, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28962787/novel-apigenin-loaded-sodium-hyaluronate-nano-assemblies-for-targeting-tumor-cells
#13
Ting Zhao, Yue He, Huali Chen, Yan Bai, Wenjing Hu, Liangke Zhang
We aimed to construct a novel nano-assembly carrying apigenin (APG), a hydrophobic drug, and to evaluate its in vitro targeting ability for A549 cells overexpressing CD44 receptors. The apigenin-loaded sodium hyaluronate nano-assemblies (APG/SH-NAs) were assembled by multiple non-covalent interactions between sodium hyaluronate (SH) and APG. The prepared APG/SH-NAs exhibited a small average size and narrow particle size distribution. In addition, satisfactory encapsulation efficiency and drug loading were obtained...
December 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28962085/effects-of-apigenin-pretreatment-against-renal-ischemia-reperfusion-injury-via-activation-of-the-jak2-stat3-pathway
#14
Yang Liu, Lei Wang, Yang Du, Zhiyuan Chen, Jia Guo, Xiaodong Weng, Xiao Wang, Min Wang, Danyang Chen, Xiuheng Liu
The aim of our study is to investigate the protective effect of apigenin and the role of the JAK2/STAT3 signaling pathway in renal ischemia/reperfusion injury (IRI) in rats. For in vivo experiments, rat kidneys were subjected to 45min of ischemia, followed by 24h of reperfusion. The kidneys were pretreated for 24h with apigenin (4mg/kg) intraperitoneally in the absence or presence of the JAK2 kinase-specific inhibitor AZD1480 (30mg/kg). The serum creatinine and urea nitrogen levels were analyzed. Histologic examinations were evaluated...
September 25, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28959843/-density-functional-theory-investigation-on-antioxidant-activity-of-five-flavonoids-from-hebei-xiangju
#15
Dong-Bao Hu, De-Liang Li, Ming Li, Xian-Xue Wu
Five main flavonoids of Hebei Xiangju were studied using the Density Functional Theory (DFT) B3LYP method with 6-311 G (d) basis set.Their activities were analyzed based on molecular structure,bond dissociation energy (BDE),natural orbital charge distribution (NBO),bond order and the energy gap between HOMO and LUMO. The results showed that the existing of intra molecular hydrogen bond in B ring can improve the antioxidant activity of the flavonoids, at the same time, the hydroxyl groups on the glycosides do not have the activity of eliminating free radicals, but decrease the total molecular antioxidant activity...
February 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28958517/antioxidant-phenolic-compounds-isolated-from-wild-pyrus-ussuriensis-maxim-fruit-peels-and-leaves
#16
Daren Qiu, Jie Guo, Huimei Yu, Jiao Yan, Shengxiang Yang, Xiang Li, Yamei Zhang, Jinzhu Sun, Jie Cong, Shuliang He, Dongsheng Wei, Jian-Chun Qin
Thirteen phenolic compounds were isolated from pear (Pyrus ussuriensis Maxim.) peels and leaves extracts by using various column chromatography techniques with a guided DPPH (1,1-diphenyl-2-picrylhydrazyl) radical-scavenging assay, the result of antioxidant activity of phenolic compounds is then verified by measurement of ROS (reactive oxygen species). The isolated compounds were identified as rutin (1), (-)-catechin (2), orobol (3), daidzein (4), tricin 4'-O-[threo-β-guaiacyl-(7″-O-methyl)-glyceryl] ether (5), tricin 4'-O-[threo-β-guaiacyl-(7″-O-methyl-9″-O-acetyl)-glyceryl] ether (6), 5,7,3',5'-tetrahydroxyflavanone (7), artselaeroside A (8), trilobatin (9), 3-(2,4,6-trihydroxyphenyl)-1-(4-hydroxyphenyl)-propan-1-one (10), quercetin-3-O-(3″-O-galloyl)-α-l-rhamnopyranoside (11), apigenin (12) and quercetin (13) on the basis of nuclear magnetic resonance spectroscopy along with comparison with literature data...
February 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28957003/in-vitro-effect-of-apigenin-and-danshen-in-tibial-dyschondroplasia-through-inhibition-of-heat-shock-protein-90-and-vascular-endothelial-growth-factor-expressions-in-avian-growth-plate-cells
#17
Khalid Mehmood, Hui Zhang, Muhammad Kashif Iqbal, Mujeeb Ur Rehman, Muhammad Shahzad, Kun Li, Shucheng Huang, Fazul Nabi, Lihong Zhang, Jiakui Li
Tibial dyschondroplasia (TD) is one of the common skeletal abnormalities in fast-growing birds, and it is characterized by nonvascularized, unmineralized, and nonviable cartilage in the tibial growth plate that fails to form bone. The aim of this study was to check the in vitro effect of apigenin and danshen on heat-shock protein 90 (Hsp90) and vascular endothelial growth factor (VEGF) expressions in avian growth plate cells treated with sublethal concentration of thiram. Initially, chondrocytes from chicken growth plates were isolated on culturx ed medium with and without various concentration of thiram to determine the sublethal dose...
September 2017: Avian Diseases
https://www.readbyqxmd.com/read/28956846/anticarcinogenic-effect-of-spices-due-to-phenolic-and-flavonoid-compounds-in-vitro-evaluation-on-prostate-cells
#18
Zuzana Lackova, Hana Buchtelova, Zaneta Buchtova, Borivoj Klejdus, Zbynek Heger, Martin Brtnicky, Jindrich Kynicky, Ondrej Zitka, Vojtech Adam
This study shows the effects of spices, and their phenolic and flavonoid compounds, on prostate cell lines (PNT1A, 22RV1 and PC3). The results of an MTT assay on extracts from eight spices revealed the strongest inhibitory effects were from black pepper and caraway seed extracts. The strongest inhibitory effect on prostatic cells was observed after the application of extracts of spices in concentration of 12.5 mg·mL(-1). An LC/MS analysis identified that the most abundant phenolic and flavonoid compounds in black pepper are 3,4-dihydroxybenzaldehyde and naringenin chalcone, while the most abundant phenolic and flavonoid compounds in caraway seeds are neochlorogenic acid and apigenin...
September 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28956831/dna-protecting-activities-of-nymphaea-nouchali-burm-f-flower-extract-attenuate-t-bhp-induced-oxidative-stress-cell-death-through-nrf2-mediated-induction-of-heme-oxygenase-1-expression-by-activating-map-kinases
#19
Md Badrul Alam, Mi-Kyoung Ju, Sang-Han Lee
This study was performed to investigate the antioxidant activities of Nymphaea nouchali flower (NNF) extract and the underlying mechanism using RAW 264.7 cells. The presence of gallic acid, catechin, epicatechin, epigallocatechin, epicatechin gallate, caffeic acid, quercetin, and apigenin in the NNF was confirmed by high-performance liquid chromatography (HPLC). The extract had a very potent capacity to scavenge numerous free radicals. NNF extract was also able to prevent DNA damage and quench cellular reactive oxygen species (ROS) generation induced by tert-Butyl hydroperoxide (t-BHP) with no signs of toxicity...
September 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28951838/alteration-in-biochemical-parameters-in-the-brain-of-transgenic-drosophila-melanogaster-model-of-parkinson-s-disease-exposed-to-apigenin
#20
Yasir Hasan Siddique, Smita Jyoti
BACKGROUND: Oxidative stress is one of the key components of the pathology of various neurodegenerative disorders. Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons owing to the aggregation of alpha-synuclein (αS) in the brain. A number of polyphenols have been reported to inhibit the αS aggregation resulting in the possible prevention of PD. The involvement of free radicals in mediating the neuronal death in PD has also been implicated. METHODS: In the present study, the transgenic flies expressing human αS in the brain were exposed to 10 μM, 20 μM, 40 μM, and 80 μM of apigenin established in diet for 24 days...
September 2017: Integrative medicine research
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