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Apigenin

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https://www.readbyqxmd.com/read/28644391/molecular-structure-affinity-relationship-of-flavonoids-in-lotus-leaf-nelumbo-nucifera-gaertn-on-binding-to-human-serum-albumin-and-bovine-serum-albumin-by-spectroscopic-method
#1
Xiaosheng Tang, Ping Tang, Liangliang Liu
Lotus leaf has gained growing popularity as an ingredient in herbal formulations due to its various activities. As main functional components of lotus leaf, the difference in structure of flavonoids affected their binding properties and activities. In this paper, the existence of 11 flavonoids in lotus leaf extract was confirmed by High Performance Liquid Chromatography (HPLC) analysis and 11 flavonoids showed various contents in lotus leaf. The interactions between lotus leaf extract and two kinds of serum albumins (human serum albumin (HSA) and bovine serum albumin (BSA)) were investigated by spectroscopic methods...
June 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28642838/adaptive-pathways-and-emerging-strategies-overcoming-treatment-resistance-in-castration-resistant-prostate-cancer
#2
Cameron M Armstrong, Allen C Gao
The therapies available for prostate cancer patients whom progress from hormone-sensitive to castration resistant prostate cancer include both systemic drugs, including docetaxel and cabazitaxel, and drugs that inhibit androgen signaling such as enzalutamide and abiraterone. Unfortunately, it is estimated that up to 30% of patients have primary resistance to these treatments and over time even those who initially respond to therapy will eventually develop resistance and their disease will continue to progress regardless of the presence of the drug...
October 2016: Asian Journal of Urology
https://www.readbyqxmd.com/read/28630625/quantification-of-antioxidant-phenolic-compounds-in-a-new-chrysanthemum-cultivar-by-high-performance-liquid-chromatography-with-diode-array-detection-and-electrospray-ionization-mass-spectrometry
#3
Ah-Reum Han, Hyo Young Kim, Yangkang So, Bomi Nam, Ik-Soo Lee, Joo-Won Nam, Yeong Deuk Jo, Sang Hoon Kim, Jin-Baek Kim, Si-Yong Kang, Chang Hyun Jin
The flowers of Chrysanthemum morifolium Ramat. have been used as an herbal tea and in traditional medicine, and the plant has been developed to produce horticultural cultivars of various colors and shapes. In this study, a new chrysanthemum cultivar with dark purple petals (C. morifolium cv. ARTI-Dark Chocolate; ADC) was developed by radiation-induced mutation breeding of its original cultivar with purple striped white petals (C. morifolium cv. Noble Wine, NW). The phenolic profile and antioxidant property of ADC were investigated and compared with NW and the commercially available medicinal herb, C...
2017: International Journal of Analytical Chemistry
https://www.readbyqxmd.com/read/28629185/leptadenia-reticulata-retz-wight-arn-jivanti-botanical-agronomical-phytochemical-pharmacological-and-biotechnological-aspects
#4
REVIEW
Sudipta Kumar Mohanty, Mallappa Kumara Swamy, Uma Rani Sinniah, Maniyam Anuradha
Leptadenia reticulata (Retz.) Wight & Arn. (Apocynaceae), is a traditional medicinal plant species widely used to treat various ailments such as tuberculosis, hematopoiesis, emaciation, cough, dyspnea, fever, burning sensation, night blindness, cancer, and dysentery. In Ayurveda, it is known for its revitalizing, rejuvenating, and lactogenic properties. This plant is one of the major ingredients in many commercial herbal formulations, including Speman, Envirocare, Calshakti, Antisept, and Chyawanprash. The therapeutic potential of this herb is because of the presence of diverse bioactive compounds such as α-amyrin, β-amyrin, ferulic acid, luteolin, diosmetin, rutin, β-sitosterol, stigmasterol, hentricontanol, a triterpene alcohol simiarenol, apigenin, reticulin, deniculatin, and leptaculatin...
June 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28627294/polyphenolic-characterisation-and-bioactivity-of-an-oxalis-pes-caprae-l-leaf-extract
#5
Marisa C Gaspar, Diogo A Fonseca, Manuel J Antunes, Christian Frigerio, Nelson G M Gomes, M Vieira, Armanda E Santos, Maria T Cruz, Maria D Cotrim, Maria G Campos
The present work is focused on the characterisation of the polyphenolic content of an Oxalis pes-caprae L. leaf extract and on the evaluation of its bioactivity with particular interest on its vascular activity and antioxidant potential. The polyphenolic content was characterised by HPLC-DAD and LC-MS/MS. The vascular activity was evaluated according to the influence on the serotonergic and adrenergic systems of the human internal mammary artery (HIMA). Antioxidant and neuroprotective studies were also conducted...
June 18, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28626741/isolation-and-identification-of-two-phenolic-compounds-from-a-moderately-cytotoxic-fraction-of-cousinia-verbascifolia-bunge
#6
Seyed Ebrahim Sajjadi, Mustafa Ghanadian, Mehrangiz Haghighi
BACKGROUND: Little information is available about chemical components of the Cousinia genus. A primary cytotoxicity screening on Cousinia verbascifolia showed moderate cytotoxic activity against OVCAR-3 ovarian and HT-29 colon cancer cells. Therefore, the aim of this study is a phytochemical investigation to identify the compounds responsible for this bioactivity. MATERIALS AND METHODS: Extraction was done through percolation and fractionations by reverse phase column chromatography and normal column chromatography...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28626476/chemical-compositions-and-biological-activities-of-scutellaria-pinnatifida-a-hamilt-aerial-parts
#7
Abbas Delazar, Hossein Nazemiyeh, Fariba Heshmati Afshar, Niloofar Barghi, Solmaz Esnaashari, Parina Asgharian
Phytochemical analysis of the methanolic and dichloromethane extracts of the aerial parts of Scutellaria pinnatifida led to the isolation of a phenylpropanoid, 1-o-feruloyl-β-D-glucose (1), two known flavonoids including luteolin-7-o-glucoside (2) and apigenin-7-o-glucoside (3), three known phenylethanoid glycosides composed of phlomisethanoside (4), syringalide A (5), and verbascoside (6), and oleic acid (7). Isolation and structural elucidation of compounds were accomplished by HPLC and spectroscopic methods (UV, (1)H-NMR, (13)C-NMR)...
June 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28623737/rumpictuside-a-unusual-9-10-anthraquinone-glucoside-from-rumex-pictus-forssk
#8
Walaa A El-Kashak, Abdelsamed I Elshamy, Tarik A Mohamed, Abd El-Nasser G El Gendy, Ibrahim A Saleh, Akemi Umeyama
A new 8-ionized hydroxylated 9,10-anthraquinone namely, 1-hydroxy-3-methyl-9,10-anthraquinone-6-O-β-D-glucopyranoside-8-olate (Rumpictuside A, 1) along with five known flavonoids, apigenin 7-O-β-D-glucoside (2), vitexin (3), quercetin 3-O-β-D-glucouronide (4), orientin (5), and isorientin (6) were isolated from Rumex pictus. The structures of isolated compounds were identified by the extensive spectroscopic techniques such as, UV, FT-IR, 1D, 2D NMR and HR-FAB-ESI-MS. The ionized hydroxyl group in the new anthraquinone (1) was rarely found for anthraquinone glycosides isolated from natural sources...
June 9, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28622621/development-of-an-ultra-fast-liquid-chromatography-tandem-mass-spectrometry-method-for-simultaneous-determination-of-seven-flavonoids-in-rat-plasma-application-to-a-comparative-pharmacokinetic-investigation-of-ginkgo-biloba-extract-and-single-pure-ginkgo-flavonoids
#9
Tianyang Wang, Jie Xiao, Huiping Hou, Pei Li, Ziyue Yuan, Huarong Xu, Ran Liu, Qing Li, Kaishun Bi
For deeper pharmacokinetic investigation and further curative application of ginkgo flavonoids, a delicate, efficient and precise UFLC-MS/MS technique for synchronous quantitation of seven flavonoids, apigenin, luteolin, naringenin, quercetin, diosmetin, kaempferol and isorhamnetin in rat plasma has been established. After mixing with the internal standard (IS) linarin, bio-samples were pretreated via ethyl acetate for liquid-liquid extraction, then isolated at 0.2ml/min flow rate on a Venusil MP C18 chromatographic column (100mm×2...
May 30, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28620306/characterization-of-antileishmanial-compounds-from-lawsonia-inermis-l-leaves-using-semi-high-resolution-antileishmanial-profiling-combined-with-hplc-hrms-spe-nmr
#10
Kashif Iqbal, Javeid Iqbal, Dan Staerk, Kenneth T Kongstad
This work describes an analytical platform based on semi-high-resolution antileishmanial profiling combined with hyphenation of high-performance liquid chromatography - high-resolution mass spectrometry - solid-phase extraction - nuclear magnetic resonance spectroscopy, i.e., semiHR-antileishmanial assay/HPLC-HRMS-SPE-NMR. The platform enables fast pinpointing of HPLC peaks representing Leishmania tropica inhibitors in complex matrices, with subsequent structural identification of targeted inhibitors. Active analytes were cumulatively trapped on SPE cartridges and the structures elucidated by analysis of NMR spectra obtained in the HPLC-HRMS-SPE-NMR mode...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28617956/apigenin-induces-ros-dependent-apoptosis-and-er-stress-in-human-endometriosis-cells
#11
Sunwoo Park, Whasun Lim, Fuller W Bazer, Gwonhwa Song
Apigenin is a plant-derived flavonoid having anti-proliferative, anti-inflammatory and anti-angiogenic properties in chronic and metabolic diseases, and cancers. However, the functional role of apigenin remains to be identified in human endometriosis that is a benign inflammatory disease causing infertility, dysmenorrhea, dyspareunia, and chronic abdominal or pelvic pain. In the present study, we determined the effects of apigenin on two well-established human endometriosis cell lines (VK2/E6E7 and End1/E6E7)...
June 15, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28614059/apigenin-sensitizes-bel-7402-adm-cells-to-doxorubicin-through-inhibiting-mir-101-nrf2-pathway
#12
Ai-Mei Gao, Xiao-Yu Zhang, Zun-Ping Ke
Chemo-resistance is one of the main obstacle in hepatocellular carcinoma therapy. Apigenin as a natural bioflavonoid has been exhibited anti-cancer properties in various malignant cancers. The aim of this study is to evaluate the potential chemo-sensitization effect of apigenin in doxorubicin-resistant hepatocellular carcinoma cell line BEL-7402/ADM and to investigate its possible mechanism. We found that apigenin significantly reversed doxorubicin sensitivity and induced caspase-dependent apoptosis in BEL-7402/ADM cells...
May 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28611737/de-novo-biosynthesis-of-apigenin-luteolin-and-eriodictyol-in-the-actinomycete-streptomyces-albus-and-production-improvement-by-feeding-and-spore-conditioning
#13
Laura Marín, Ignacio Gutiérrez-Del-Río, Paula Yagüe, Ángel Manteca, Claudio J Villar, Felipe Lombó
Nutraceutical compounds as plant flavonoids play an important role in prevention and modulation of diverse heath conditions, as they exert interesting antifungal, antibacterial, antioxidant, and antitumor effects. They also possess anti-inflammatory activities in arthritis, cardiovascular disease or neurological diseases, as well as modulatory effects on the CYP450 activity on diverse drugs. Most flavonoids are bioactive molecules of plant origin, but their industrial production is sometimes hindered due to reasons as low concentration in the plant tissues, presence in only some species or as a complex mixture or inactive glycosides in plant vacuolae...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28605679/a-re-investigation-of-the-phytochemical-composition-of-the-edible-herb-amaranthus-retroflexus-l
#14
Serena Fiorito, Francesco Epifano, Roberta Palmisano, Salvatore Genovese, Vito Alessandro Taddeo
In this paper the presence of selected prenylated and unprenylated phenylpropanoids of nutraceutical value, namely umbelliferone, apigenin, 4'-geranyloxyferulic acid, 7-isopentenyloxycoumarin, auraptene, and umbelliprenin have been determined in all parts of the edible herb Amaranthus retroflexus extracted with different methodologies. Roots were seen to contain the widest variety of unprenylated and prenylated phenylpropanoids both in terms of number of secondary metabolites and their quantitites. Findings described in the present study underline how A...
June 3, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28603044/relaxation-of-isolated-guinea-pig-trachea-by-apigenin-a-constituent-of-celery-via-inhibition-of-phosphodiesterase
#15
Junn-Lain Chen, Wun-Chang Ko
Apigenin, was reported to have vasodilatory effects by inhibiting Ca(2+) influx through both voltage- and receptor-operated calcium channels, but not by inhibiting cAMP- or cGMP-phosphodiesterases (PDEs) in rat thoracic aorta. However, apigenin was reported to inhibit PDE1, 2 and 3 in guinea-pig lung and heart. The aim of this study was to clarify that guinea-pig tracheal relaxation by apigenin whether via PDE inhibition. We isometrically recorded the tension of isolated guinea-pig tracheal segments on a polygraph...
June 9, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28599704/new-horizons-in-the-extraction-of-bioactive-compounds-using-deep-eutectic-solvents-a-review
#16
REVIEW
Mohamad Hamdi Zainal-Abidin, Maan Hayyan, Adeeb Hayyan, Natesan Subramanian Jayakumar
With the rapid development of ionic liquid analogues, termed 'deep eutectic solvents' (DESs), and their application in a wide range of chemical and biochemical processes in the past decade, the extraction of bioactive compounds has attracted significant interest. Recently, numerous studies have explored the extraction of bioactive compounds using DESs from diverse groups of natural sources, including animal and plant sources. This review summarizes the-state-of-the-art effort dedicated to the application of DESs in the extraction of bioactive compounds...
August 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28598487/apigenin-exhibits-protective-effects-in-a-mouse-model-of-d-galactose-induced-aging-via-activating-the-nrf2-pathway
#17
Ying Sang, Fan Zhang, Heng Wang, Jianqiao Yao, Ruichuan Chen, Zhengdao Zhou, Kun Yang, Yan Xie, Tianfeng Wan, Hong Ding
The aim of the present research was to study the protective effects and underlying mechanisms of apigenin on d-galactose-induced aging mice. Firstly, apigenin exhibited a potent antioxidant activity in vitro. Secondly, d-galactose was administered by subcutaneous injection once daily for 8 weeks to establish an aging mouse model to investigate the protective effect of apigenin. We found that apigenin supplementation significantly ameliorated aging-related changes such as behavioral impairment, decreased organic index, histopathological injury, increased senescence-associated β-galactosidase (SAβ-gal) activity and advanced glycation end product (AGE) level...
June 9, 2017: Food & Function
https://www.readbyqxmd.com/read/28597426/anti-hepatitis-antioxidant-activities-and-bioactive-compounds-of-dracocephalum-heterophyllum-extracts
#18
Qiang-Qiang Shi, Jun Dang, Huai-Xiu Wen, Xiang Yuan, Yan-Duo Tao, Qi-Lan Wang
BACKGROUND: Dracocephalum heterophyllum was a traditional Tibetan medicine possesses various pharmacological effects involved in anti-inflammatory, antibacterial activities. However, its anti-hepatitis, antioxidant activity and bioactive compounds have not been reported, the objective of this research work was to investigate the pharmacological activity and bioactive compounds of D. heterophyllum extracts. RESULTS: In the present study, the anti-hepatics and antioxidant activities of four D...
December 2016: Botanical Studies (Taipei, Taiwan)
https://www.readbyqxmd.com/read/28587909/identification-of-a-flavonoid-c-glycoside-as-potent-antioxidant
#19
Lingrong Wen, Yupeng Zhao, Yueming Jiang, Limei Yu, Xiaofang Zeng, Jiali Yang, Miaomiao Tian, Huiling Liu, Bao Yang
Flavonoids have been documented to have good antioxidant activities in vitro. However, reports on the cellular antioxidant activities of flavonoid C-glycosides are very limited. In this work, an apigenin C-glycoside was purified from Artocarpus heterophyllus by column chromatography and was identified to be 2″-O-β-D-xylosylvitexin by nuclear magnetic resonance spectroscopy. The cellular antioxidant activity and anticancer activity of 2″-O-β-D-xylosylvitexin were evaluated for the first time. The quantitative structure-activity relationship was analysed by molecular modeling...
June 3, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28583392/a-novel-molybdenum-disulfide-nanosheet-self-assembled-flower-like-monolithic-sorbent-for-solid-phase-extraction-with-high-efficiency-and-long-service-life
#20
Fanpeng Ran, Hongmei Liu, Xiaoqi Wang, Yong Guo
A novel material consisting of molybdenum disulfide (MoS2) nanosheet that self-assemble into flower-like microspheres which aggregate to form a monolithic matrix with a micro or nano-scaled mesopore structure was successfully synthesized and used as an efficient sorbent for solid-phase extraction (SPE) due to its large specific adsorption area and good stability. The extraction properties of the as-prepared sorbent were evaluated by high-performance liquid chromatography with variable wavelength detection (HPLC-VWD) by analyzing four flavonoids (apigenin, quercetin, luteolin, and kaempferol)...
May 8, 2017: Journal of Chromatography. A
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