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Apigenin

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https://www.readbyqxmd.com/read/28074384/microfluidic-gut-liver-chip-for-reproducing-the-first-pass-metabolism
#1
Aerim Choe, Sang Keun Ha, Inwook Choi, Nakwon Choi, Jong Hwan Sung
After oral intake of drugs, drugs go through the first pass metabolism in the gut and the liver, which greatly affects the final outcome of the drugs' efficacy and side effects. The first pass metabolism is a complex process involving the gut and the liver tissue, with transport and reaction occurring simultaneously at various locations, which makes it difficult to be reproduced in vitro with conventional cell culture systems. In an effort to tackle this challenge, here we have developed a microfluidic gut-liver chip that can reproduce the dynamics of the first pass metabolism...
March 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28070575/network-pharmacology-based-virtual-screening-of-natural-products-from-clerodendrum-species-for-identification-of-novel-anti-cancer-therapeutics
#2
Barbi Gogoi, Dhrubajyoti Gogoi, Yumnam Silla, Bibhuti Bhushan Kakoti, Brijmohan Singh Bhau
Plant-derived natural products (NPs) play a vital role in the discovery of new drug molecules and these are used for development of novel therapeutic drugs for a specific disease target. Literature review suggests that natural products possess strong inhibitory efficacy against various types of cancer cells. Clerodendrum indicum and Clerodendrum serratum are reported to have anticancer activity; therefore a study was carried out to identify selective anticancer agents from these plants species. In this report, we employed a docking weighted network pharmacological approach to understand the multi-therapeutics potentiality of C...
January 10, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28064632/protective-effects-of-apigenin-and-myricetin-against-cisplatin-induced-nephrotoxicity-in-mice
#3
Samar M Hassan, Marwa M Khalaf, Sawsan A Sadek, Amira M Abo-Youssef
CONTEXT: Currently, the outcomes of the use of cisplatin in cancer therapy is limited by nephrotoxicity. OBJECTIVE: This study aims to investigate the nephroprotective role of apigenin and myricetin against cisplatin-induced nephrotoxicity in mice. MATERIALS AND METHODS: Adult female Wistar Albino mice were divided into eight groups (n = 8). Group I served as normal control. Groups II, III and IV received apigenin (3 mg/kg, i.p.), myricetin (3 mg/kg, i...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28061797/natural-compounds-targeting-major-cell-signaling-pathways-a-novel-paradigm-for-osteosarcoma-therapy
#4
REVIEW
Pablo Angulo, Gaurav Kaushik, Dharmalingam Subramaniam, Prasad Dandawate, Kathleen Neville, Katherine Chastain, Shrikant Anant
Osteosarcoma is the most common primary bone cancer affecting children and adolescents worldwide. Despite an incidence of three cases per million annually, it accounts for an inordinate amount of morbidity and mortality. While the use of chemotherapy (cisplatin, doxorubicin, and methotrexate) in the last century initially resulted in marginal improvement in survival over surgery alone, survival has not improved further in the past four decades. Patients with metastatic osteosarcoma have an especially poor prognosis, with only 30% overall survival...
January 7, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28058739/comparative-study-of-the-binding-of-3-flavonoids-to-the-fat-mass-and-obesity-associated-protein-by-spectroscopy-and-molecular-modeling
#5
Lijiao Zhang, Ting Ren, Zechun Wang, Ruiyong Wang, Junbiao Chang
This study aims to investigate the interaction between 3 flavonoids (quercetin, apigenin, and naringenin) and fat mass and obesity-associated protein by fluorescence, ultraviolet-visible absorption spectroscopy, and molecular modeling. Results indicate that the intrinsic fluorescence of fat mass and obesity-associated protein can be quenched by the 3 flavonoids through a static quenching procedure. Thermodynamic analysis and molecular modeling results suggest that hydrophobic interaction and hydrogen bond forces play the major roles in the binding process...
January 6, 2017: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/28056971/inhibition-of-epstein-barr-virus-reactivation-by-the-flavonoid-apigenin
#6
Chung-Chun Wu, Chih-Yeu Fang, Yu-Jhen Cheng, Hui-Yu Hsu, Sheng-Ping Chou, Sheng-Yen Huang, Ching-Hwa Tsai, Jen-Yang Chen
BACKGROUND: Lytic reactivation of EBV has been reported to play an important role in human diseases, including NPC carcinogenesis. Inhibition of EBV reactivation is considered to be of great benefit in the treatment of virus-associated diseases. For this purpose, we screened for inhibitory compounds and found that apigenin, a flavonoid, seemed to have the ability to inhibit EBV reactivation. METHODS: We performed western blotting, immunofluorescence and luciferase analyses to determine whether apigenin has anti-EBV activity...
January 5, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28053955/role-of-apigenin-in-cancer-prevention-via-the-induction-of-apoptosis-and-autophagy
#7
REVIEW
Bokyung Sung, Hae Young Chung, Nam Deuk Kim
Apigenin (4',5,7-trihydroxyflavone) is a flavonoid commonly found in many fruits and vegetables such as parsley, chamomile, celery, and kumquats. In the last few decades, recognition of apigenin as a cancer chemopreventive agent has increased. Significant progress has been made in studying the chemopreventive aspects of apigenin both in vitro and in vivo. Several studies have demonstrated that the anticarcinogenic properties of apigenin occur through regulation of cellular response to oxidative stress and DNA damage, suppression of inflammation and angiogenesis, retardation of cell proliferation, and induction of autophagy and apoptosis...
December 2016: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28050929/development-and-optimization-of-apigenin-loaded-transfersomal-system-for-skin-cancer-delivery-in-vitro-evaluation
#8
Manmohan Singh Jangdey, Anshita Gupta, Shailendra Saraf, Swarnlata Saraf
The aim of this work is to apply Box-Behnken design to optimize the transfersomes were formulated by modified rotary evaporation sonication technique using surfactant Tween 80. The response surface methodology was used having three-factored with three levels. The prepared formulations were characterized for vesicle shape, size, entrapment efficiency (%), stability, and in vitro permeation. The result showed that drug entrapment of 84.24% with average vesicle size of 35.41 nm and drug loading of 8.042%. Thus, optimized formulation was found good stability and is a promising approach to improve the permeability of apigenin in sustained release for prolonged period of time...
January 4, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28050761/role-of-the-polycarboxylic-compounds-in-the-response-of-silene-vulgaris-to-chromium
#9
Ana E Pradas Del Real, Jose Manuel Silvan, Sonia de Pascual-Teresa, Ana Guerrero, Pilar García-Gonzalo, M Carmen Lobo, Araceli Pérez-Sanz
This work aims to investigate the nature and the specific mechanisms by which polycarboxylic compounds participate in the tolerance of Silene vulgaris to Cr with special attention given to the rhizosphere system. This knowledge is important to use this species in the implementation of phytoremediation technologies in Cr-polluted soils. According to the results, chromium is chelated and mobilized by the citric and malic acids in plant tissues, while oxalic acid might participate in the reduction and chelation of Cr in the rhizosphere...
January 3, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28036089/chemical-composition-and-antioxidant-activity-of-euterpe-oleracea-roots-and-leaflets
#10
Christel Brunschwig, Louis-Jérôme Leba, Mona Saout, Karine Martial, Didier Bereau, Jean-Charles Robinson
Euterpe oleracea (açaí) is a palm tree well known for the high antioxidant activity of its berries used as dietary supplements. Little is known about the biological activity and the composition of its vegetative organs. The objective of this study was to investigate the antioxidant activity of root and leaflet extracts of Euterpe oleracea (E. oleracea) and characterize their phytochemicals. E. oleracea roots and leaflets extracts were screened in different chemical antioxidant assays (DPPH-2,2-diphenyl-1-picrylhydrazyl, FRAP-ferric feducing antioxidant power, and ORAC-oxygen radical absorbance capacity), in a DNA nicking assay and in a cellular antioxidant activity assay...
December 29, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28035114/an-in-vitro-study-of-antileishmanial-effect-of-portulaca-oleracea-extract
#11
Elham Gharirvand Eskandari, Monir Doudi, Saeid Abedi
BACKGROUND & OBJECTIVES: Leishmaniasis is caused by protozoa of Leishmania genus and is considered as a zoonotic disease. It is a major public health problem worldwide, with high endemicity in developing countries like Iran. Various chemical drugs are used for leishmaniasis treatment, but their side-effects and the emergence of drug resistance have led to look for new effective compounds. The aim of this study was to introduce purslane (Portulaca oleracea) as a traditional and medicinal herb which might act as a valuable source for designing new pharmaceutical drug/lead against Leishmania sp...
October 2016: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/28025554/antioxidant-activities-and-chemical-constituents-of-flavonoids-from-the-flower-of-paeonia-ostii
#12
Huifang Zhang, Xiaofang Li, Ke Wu, Mengke Wang, Pu Liu, Xinsheng Wang, Ruixue Deng
Paeonia ostii is a traditional medicinal plant popularly used in China. This study intended to evaluate the antioxidant properties and the chemical components of the flavonoid-rich extracts from the flowers of P. ostii. The results showed that the flavonoid-rich extracts from the flowers of P. ostii had strong scavenging capacities on 2,2'-Azinobis-(3-ethylbenzthiazoline-6-sulphonate) (ABTS), hydroxyls, superoxide anions, and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals in a dose-dependent manner. Five flavonoids, dihydrokaempferol (1), apigenin-7-O-β-d-glucoside (2), apigenin-7-O-β-d-neohesperidoside (3), kaempferol-7-O-β-d-glucopyranoside (4), and kaempferol-3-O-β-d-glucopyranosyl-7-O-β-d-glucopyranoside (5), were isolated from the flavonoid-rich extracts of the flowers of P...
December 23, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28025107/apigenin-potentiates-the-antitumor-activity-of-5-fu-on-solid-ehrlich-carcinoma-crosstalk-between-apoptotic-and-jnk-mediated-autophagic-cell-death-platforms
#13
Hanaa H Gaballah, Rasha A Gaber, Darin A Mohamed
BACKGROUND: Although 5- Fluorouracil (5-FU) has exhibited effectiveness against cancer, novel therapeutic strategies are needed to enhance its antitumor efficiency and modulate its cytotoxity. Apigenin, a flavonoid present in fruits and vegetables, is a potent dietary phytochemical effective in cancer chemoprevention. AIM: This study was undertaken to investigate the potential synergistic antitumor activity of apigenin and 5-FU on Solid Ehrlich carcinoma (SEC). METHODS: Eighty Swiss albino male mice were divided into four equal groups: vehicle treated control SEC, SEC+5-FU, SEC+apigenin, SEC+ 5-FU+apigenin...
December 23, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28024940/a-new-flavonoid-glycoside-apg-isolated-from-clematis-tangutica-attenuates-myocardial-ischemia-reperfusion-injury-via-activating-pkc%C3%AE%C2%B5-signaling
#14
Yanrong Zhu, Shouyin Di, Wei Hu, Yingda Feng, Qing Zhou, Bing Gong, Xinlong Tang, Juntian Liu, Wei Zhang, Miaomiao Xi, Lin Jiang, Chao Guo, Jingyi Cao, Chongxi Fan, Zhiqiang Ma, Yang Yang, Aidong Wen
Clematis tangutica has been shown to be beneficial for the heart; however, the mechanism of this effectremains unknown. Apigenin-7-O-β-D-(-6″-p-coumaroyl)-glucopyranoside (APG) is a new flavonoid glycoside isolated from Clematis tangutica. This study investigates the effects of APG on myocardial ischemia/reperfusion (IR) injury (IRI). An IRI model of primary myocardial cells and mice was used in this study. Compared with the IR group, APG preconditioning is protective against IRI in primary myocardial cells and in mice hearts in a dose-dependent manner...
December 24, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28024731/olive-oil-polyphenols-a-quantitative-method-by-high-performance-liquid-chromatography-diode-array-detection-for-their-determination-and-the-assessment-of-the-related-health-claim
#15
Massimo Ricciutelli, Shara Marconi, Maria Chiara Boarelli, Giovanni Caprioli, Gianni Sagratini, Roberto Ballini, Dennis Fiorini
In order to assess if an extra virgin olive oil (EVOO) can be acknowledged with the health claim related to olive oil polyphenols (Reg. EU n.432/2012), a new method to quantify these species in EVOO, by means of liquid-liquid extraction followed by HPLC-DAD/MS/MS of the hydroalcoholic extract, has been developed and validated. Different extraction procedures, different types of reverse-phase analytical columns (Synergi Polar, Spherisorb ODS2 and Kinetex) and eluents have been tested. The chromatographic column Synergi Polar (250×4...
December 11, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28012918/enhanced-chemotherapeutic-efficacy-of-apigenin-liposomes-in-colorectal-cancer-based-on-flavone-membrane-interactions
#16
Kacoli Banerjee, Shubhadeep Banerjee, Mahitosh Mandal
Recent endeavors in exploiting vast array of natural phytochemicals to ameliorate colorectal cancer led us to investigate apigenin, a naturally occurring dietary flavone as a potential chemo-therapeutic agent. The present study focuses on establishing apigenin as a potential chemotherapeutic agent for alleviating colorectal cancer and reports the development of a stable liposomal nanocarrier with high encapsulation of the hydrophobic flavone apigenin for enhanced chemotherapeutic effects. The enhanced pharmacological activity of apigenin has been assigned to its ability to interact and subsequently influence membrane properties which also resulted in optimal yield of a stable, rigidified, non-leaky nano-carrier with ideal release kinetics...
December 18, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28012393/modulatory-effect-of-standardised-amentoflavone-isolated-from-juniperus-communis-l-agianst-freund-s-adjuvant-induced-arthritis-in-rats-histopathological-and-x-ray-anaysis
#17
Souravh Bais, Naveena Abrol, Yash Prashar, Renu Kumari
ETHOPHARMACOLOGIC RELEVANCE: Juniperus communis. L. is a shrub or small evergreen tree, native to Europe, South Asia, and North America, and belongs to family Cupressaceae. It has been used traditionally in unani system and in Swedish medicine as a decoction in inflammatory diseases. The main chemical constituents, which were reported in J. communis L. was α-pinene,, apigenin, sabinene, β-sitosterol, campesterol, limonene, Amentoflavone (AF), cupressuflavone, and many others. AIM: The aim of present study was to isolate the amentoflavone from the plant juniperus communis L...
December 21, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27991400/isolation-of-chemical-constituents-of-centaurea-virgata-lam-and-xanthine-oxidase-inhibitory-activity-of-the-plant-extract-and-compounds
#18
Burcu S Tuzun, Zsuzsanna Hajdu, Orsolya Orban-Gyapai, Zoltan P Zomborszki, Nikoletta Jedlinszki, Peter Forgo, Bijen Kıvcak, Judit Hohmann
BACKGROUND: Centaurea virgata Lam. is a species widely used in the traditional medicine in Turkey for the treatment of diabetes, allergy and gastric ulcers. The rationale of its use in the therapy has not been studied previously, therefore the present work aimed at the chemical-pharmacological evaluation of the plant. OBJECTIVE: The xanthine oxidase (XO) inhibitory activity of the MeOH extract and its subextracts (n-hexane, CHCl3 and remaining MeOH-H2O) prepared from C...
December 19, 2016: Medicinal Chemistry
https://www.readbyqxmd.com/read/27989856/development-of-oral-site-specific-pellets-containing-flavonoid-extract-with-antioxidant-activity
#19
Zsófia Edit Pápay, Nikolett Kállai-Szabó, Krisztina Ludányi, Imre Klebovich, István Antal
Herbal medicines are recognized as an effective treatment of common diseases, mainly associated with oxidative stress. Therefore developing drug delivery systems of these biological active ingredients are gaining interest. Parsley (Petroselinum crispum L.) is a well-known culinary herb and its leaf contains high amount of apigenin, therefore it is suitable as a natural source of this flavonoid. Apigenin possess many health effects such as antioxidant, anti-inflammatory and anticancer activities. Unfortunately, these benefits are limited due to the low water solubility and bioavailability, it was recently classified as BCS II group compound...
October 29, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27988077/alternating-isocratic-and-step-gradient-elution-high-speed-counter-current-chromatography-for-the-isolation-of-minor-phenolics-from-ormocarpum-kirkii-bark
#20
Eutrophe Le Doux Kamto, Tatiane S C Carvalho, Joséphine Ngo Mbing, Marie C N Matene, Dieudonné E Pegnyemb, Gilda G Leitão
A total of 14 compounds were isolated from the ethanol bark extract of O. kirkii S. Moore (Fabaceae) by alternating isocratic and step gradient elution high-speed counter-current chromatography (HSCCC) methods, using several solvent systems with reference to the polarity of compounds being purified. The extract was successively fractionated with generic solvent systems including n-hexane-ethanol-water (4:2:2) and ethyl acetate-water (1:1). Resulting fractions were further purified using the following preparative gradient elution consisting of ethyl acetate-n-butanol-water (X:Y:10), (X:Y=9:1 (I); 8:2 (II); 7:3 (III); 6:4 (IV); 5:5 (V); 4:6 (VI) 3:7 (VII) and n-hexane- ethyl acetate-methanol-water (1:X:1:1), X=1, 2, 2...
January 13, 2017: Journal of Chromatography. A
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