keyword
https://read.qxmd.com/read/38515759/health-related-quality-of-life-in-patients-with-inborn-errors-of-immunity-a-bibliometric-analysis
#21
Ningkun Xiao, Xinlin Huang, Wanli Zang, Sergey Kiselev, Mikhail A Bolkov, Irina A Tuzankina, Valery A Chereshnev
BACKGROUND: Inborn Errors of Immunity (IEI) are characterized by a heightened susceptibility to infections, allergies, and various other health complications. Health-Related Quality of Life (HRQOL) in patients with IEI is a critical area of research that demands attention due to the impact of IEI on patients' lives. This study utilized bibliometric methods, aiming to comprehensively explore the research content and hotspots in the field of HRQOL in patients with IEI. METHODS: This bibliometric analysis utilized data from the Science Citation Index Expanded (SCIE) and Social Sciences Citation Index (SSCI) within the Web of Science core datasets up to January 1, 2024...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38513838/landscape-fire-smoke-airway-exposure-impairs-respiratory-and-cardiac-function-and-worsens-experimental-asthma
#22
JOURNAL ARTICLE
Henry M Gomez, Tatt J Haw, Dusan Ilic, Peter Robinson, Chantal Donovan, Amanda J Croft, Kanth S Vanka, Ellen Small, Olivia R Carroll, Richard Y Kim, Jemma R Mayall, Tesfalidet Beyene, Thava Palanisami, Doan Tm Ngo, Graeme R Zosky, Elizabeth G Holliday, Megan E Jensen, Vanessa M McDonald, Vanessa E Murphy, Peter Gibson, Jay C Horvat
BACKGROUND: Millions of people are exposed to landscape fire smoke (LFS) globally and inhalation of LFS particulate matter is associated with poor respiratory and cardiovascular outcomes. However, how LFS affects respiratory and cardiovascular function is less well understood. OBJECTIVE: To characterize the pathophysiological effects of representative LFS airway exposure on respiratory and cardiac function and on asthma outcomes. METHODS: LFS was generated using a customized combustion chamber...
March 19, 2024: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38513837/ige-to-cyclophilins-in-pollen-allergic-children-epidemiological-clinical-and-diagnostic-relevance-of-a-neglected-panallergen
#23
JOURNAL ARTICLE
Paolo Maria Matricardi, Ekaterina Potapova, Valentina Panetta, Jonas Lidholm, Lars Mattsson, Enrico Scala, Roberto Bernardini, Carlo Caffarelli, Antonella Casani, Rosa Cervone, Loredana Chini, Pasquale Comberiati, Giovanna De Castro, Michele Miraglia Del Giudice, Iride Dello Iacono, Andrea Di Rienzo Businco, Marcella Gallucci, Arianna Giannetti, Viviana Moschese, Elena Varin, Annamaria Bianchi, Mauro Calvani, Tullio Frediani, Francesco Macrì, Nunzia Maiello, Francesco Paravati, Umberto Pelosi, Diego Peroni, Giuseppe Pingitore, Mariangela Tosca, Anna Maria Zicari, Giampaolo Ricci, Riccardo Asero, Salvatore Tripodi
BACKGROUND: - Cyclophilins are ubiquitous panallergens whose epidemiological, diagnostic, and clinical relevance is largely unknown and whose sensitization is rarely examined in routine allergy practice. The aim of this study was to investigate the epidemiological, diagnostic, and clinical relevance of cyclophilin in seasonal allergic rhinitis and its comorbidities. METHODS: - We examined a random sample (25%, n 253) of 1263 Italian children affected by seasonal allergic rhinitis from the "Panallergen in Pediatrics" (PAN-PED) cohort...
March 19, 2024: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38513758/summary-of-the-dutch-multidisciplinary-practice-guideline-on-asthma-and-pregnancy
#24
REVIEW
Sarah A Bendien, Martijn D de Kruif, Hanneke Feitsma, Cathelijn van Hoolwerff-Blikkendaal, Kirsten Koehorst-Ter Huurne, Alie Kuiterman, Ekaterina V Baranova, Arjan Wittkampf, Annette Brons, Marjo Poulissen, Akke-Nynke van der Meer
Asthma is the most common chronic respiratory disease in women of childbearing age and during pregnancy. This paper presents a summary of the Dutch multidisciplinary guideline on asthma and pregnancy. The aim of this guideline is to provide structured, where possible, evidence-based recommendations to optimize the management of asthma during pregnancy. The main topics covered in this guideline are: preconception counseling, the safety of asthma medications during pregnancy and breastfeeding and risk assessment and monitoring of asthma during pregnancy...
March 19, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38512039/-research-progress-of-haematopoietic-stem-cells-to-generate-immune-cells-and-its-application
#25
JOURNAL ARTICLE
Yalin Zhang, Juanjuan Li, Penghui Yan, Jin Zhou, Yujie Zhuang, Xuemei Zhang, Xiaolong Wang, Juntao Zhang, Zhiping Zhang, Lixin Deng
Hematopoietic stem cells (HSCs) posses the potential for highly self-renewal, proliferation and multi-lineage differentiation. HSC transplantation has long been the primary method for treating hematologic disorders and autoimmune diseases, and the ability to rebuild the immune system after transplantation is a key indicator of success. To enhance the reconstruction ability of the immune system after transplantation, current research focuses on genetic engineering and the use of HSCs modified by clustered regularly interspaced short palindromic repeats (CRISPR) gene editing technology as a source of transplant cells...
March 2024: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://read.qxmd.com/read/38512038/-advances-in-the-role-and-mechanism-of-nk-cell-immune-response-mediated-by-nkg2a-hla-e-axis-in-viral-infectious-diseases
#26
JOURNAL ARTICLE
Manling Xue, Xiaoyue Xu, Xiyue Zhang, Kang Tang, Yusi Zhang, Chunmei Zhang, Ran Zhuang, Boquan Jin, Yun Zhang, Changwu Yue, Ying Ma
Natural killer (NK) cells directly lysis the virus-infected cells through rapidly releasing cytotoxic mediators and cytokines. The balance between inhibitory and activated receptors on the surface of NK cells, as well as the corresponding ligands expressed on target cells are involved in the regulation of the cytotoxic function of NK cells. NKG2A is one of the highly anticipated inhibitory receptors expressed on NK cells, which can inhibit the cytotoxicity of NK cells to autologous normal tissue cells through interacting with the ligand HLA-E...
March 2024: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://read.qxmd.com/read/38512037/-research-progress-of-cd93-b-lymphocyte-subsets-in-inflammation-and-inflammation-related-diseases
#27
JOURNAL ARTICLE
Changping Niu, Siyu Sun, Dongyan Liu
CD93 is expressed in progenitor B (pro-B) cells, precursor B (pre-B) cells and various immature B cells. It can interact with moesin, MMRN2 and other molecules to participate in cell migration, adhesion and phagocytosis, so it plays an important role in inflammation and angiogenesis. Detection of CD93+ B cell subsets has a crucial role in the diagnosis, treatment and prognosis monitoring of inflammation and inflammation-related diseases, such as Helicobacter pylori-related gastritis, sepsis, non-obese diabetes and periodontitis...
March 2024: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://read.qxmd.com/read/38512036/-preparation-and-characterization-of-chicken-anti-human-b7-h4-igy-polyclonal-antibody
#28
JOURNAL ARTICLE
Li Zhang, Zhenjun Fan, Wenting Zhang, Huanshao Huang, Jiajun Wang, Ailian Hei, Yanguang Cong, Junfa Xu
Objective To prepare anti-human B7 homolog 4 (B7-H4) egg yolk immunoglobulins (IgY) polyclonal antibody and establish a double-antibody sandwich ELISA for the detection of soluble B7-H4 (sB7-H4) protein in human serum. Methods Bioinformatics was used to screen specific B cell epitope peptides of human sB7-H4. New Hyland Grey laying hens were immunized with these peptides, and the eggs from the immunized hens were collected to purify chicken anti-human B7-H4 IgY antibody. The purity, concentration and titer of the antibody were detected, and its specificity and function of the antibodies were verified by using ELISA, Western blot analysis and flow cytometry, respectively...
March 2024: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://read.qxmd.com/read/38512035/-yes-associated-protein-yap-promotes-invasion-and-migration-of-cutaneous-squamous-cell-carcinoma-cells-by-activating-the-pi3k-akt-pathway
#29
JOURNAL ARTICLE
Zhenling Li, Fan Yang, Xuemei Jin, Xueyan Wang, Taiqin Chen, Chunji Quan
Objective To investigate the expression of Yes-associated protein (YAP) in cutaneous squamous cell carcinoma (cSCC) and its effects on invasion and migration. Methods Immunohistochemical staining was used to detect the expression of YAP in cSCC, Bowen disease (BD), and adjacent normal tissues, and analyzed the correlation between YAP expression and clinicopathological characteristics of cSCC. A stable cell line in A431 cells with YAP gene silencing was established through lentiviral infection. Tetramethylrhodamine isothiocyanate (TRITC)-phalloidin staining was performed to analyze the distribution and number of microfilaments in A431 cells...
March 2024: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://read.qxmd.com/read/38512034/-3-deazaadenosine-3-daa-accelerates-japanese-encephalitis-virus-replication-and-down-regulates-levels-of-inflammatory-factors-in-mouse-and-hamster-cells
#30
JOURNAL ARTICLE
Xueyun Li, Min Yao, Yuexiang Li, Zhirong Cheng, Shizhe Zhang, Fanglin Zhang, Xin Lyu
Objective To investigate the effect of 3-deazaadenosine (3-DAA), an N6 -methyladenosine (m6 A) methylation modification inhibitor, on the replication of the Japanese encephalitis virus (JEV). Methods Neuro2a mouse neuroblastoma cells, N9 mouse microglial cells, and BHK baby hamster kidney cells were exposed to JEV and then treated with 3-DAA. JEV was also injected into the footpad of adult C57BL/6 mice, which were then administered 3-DAA intraperitoneally. Real-time quantitative PCR was utilized to measure mRNA expression levels of JEV, interleukin 1β (IL-1β), IL-6, tumor necrosis factor α (TNF-α), monocyte chemoattractant protein 1 (MCP-1), inducible nitric oxide synthase (iNOS), arginase 1 (Arg1), interferon (IFN)-α, IFN-β, IFN-γ, and C-X-C motif chemokine ligand 10 (CXCL10) in the cells and mouse brain tissues...
March 2024: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://read.qxmd.com/read/38512033/-%C3%AE-caryophyllene-downregualtes-inflammatory-cytokine-expression-and-alleviates-systemic-inflammation-in-mice-by-inhibiting-the-nf-%C3%AE%C2%BAb-signaling-pathway
#31
JOURNAL ARTICLE
Bingye Yang, Minlong Wang, Ying Li
Objective To investigate the anti-inflammatory mechanism of β-caryophyllene (BCP) on lipopolysaccharide (LPS)-induced systemic inflammation in mice. Methods C57BL mice were divided into control group, LPS-treated group, dexamethasone-treated group, and BCP-treated group. Twelve hours after the establishment of the whole body inflammation model by intraperitoneal injection of LPS, the serum levels of interleukin 1β(IL-1β), tumor necrosis factor α (TNF-α), and IL-6 were measured by ELISA...
March 2024: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://read.qxmd.com/read/38512032/-triptolide-reduces-neuronal-damage-in-cerebral-ischemia-reperfusion-rats-by-promoting-microglial-m2-polarization
#32
JOURNAL ARTICLE
Bingtao Mu, Minfang Guo, Jingwen Yu, Huiyu Zhang
Objective To investigate the effects of triptolide (TP) on microglial M1/M2 polarization after cerebral ischemia-reperfusion (I/R) injury in rats and the underlying molecular mechanism. Methods A rat model of middle cerebral artery occlusion (MCAO) was established. TP was administered to rats at doses of 0.1 and 0.2 mg/kg, with a sham surgery group as the control group. Longa scoring was performed to grade neurological deficits in rats; HE staining was used to observe the morphology of neurons in ischemic brain tissues; neuron-specific nuclear protein (NeuN) immunofluorescence staining was used to measure the number of neurons; and Western blot analysis was used to measure the expression levels of ionised calcium-binding adaptor molecule-1 (Iba1), inducible nitric oxide synthase (iNOS), arginase 1 (Arg1), Toll-like receptor 4 (TLR4), nuclear factor κB (NF-κB), NeuN and caspase-3 in ischemic-brain tissues...
March 2024: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://read.qxmd.com/read/38512031/-the-functional-differences-of-macrophages-derived-from-murine-bone-marrow-and-peritoneal-cavity
#33
JOURNAL ARTICLE
Manjing Huang, Yanggan Luo, Zihan Lu, Weiling Wang, Doudou Hao, Hanjing Liao, Zhixiang Zhu
Objective To compare the functional differences between bone marrow derived macrophages and peritoneal macrophages, which may provide the basis for the selection of macrophages in immunological research and immunoregulatory drug evaluation. Methods Marophage colony-stimulating factor (M-CSF) was used to induce the differentiation of bone marrow monocytes into macrophages, and thioglycolate medium was used to induce peritonitis to obtain peritoneal macrophages. After both macrophages being stimulated by zymosan, LPS, R848 and CpG respectively, mRNA levels of tumor necrosis factor α(TNF-α), interleukin 6(IL-6), macrophage inflammatory protein 1α(MIP-1α), monocyte chemoattractant protein 1(MCP-1) were measured by Real-time fluorescent quantitative PCR and the concentrations of secreted TNF-α, IL-6, MIP-1α and MCP-1 were detected by ELISA...
March 2024: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://read.qxmd.com/read/38512030/-leukocyte-associated-immunoglobulin-like-receptor-1-lair-1-inhibits-proliferation-and-promotes-apoptosis-of-human-hel-cells-with-jak2-v617f-mutation-by-blocking-the-jak-stat-and-pi3k-akt-signaling-pathways
#34
JOURNAL ARTICLE
Cui Fan, Yawei Zhang, Rui Yang, Xiaojie Wu, Jiadi Zhou, Jiangnan Xue
Objective To investigate the role of human leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) in the regulation of Janus kinase/signal transducers and activators of transcription (JAK/STAT) and phosphatidylinositol 3 kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT /mTOR) signaling pathways in human acute myeloid leukemia HEL cells carrying the JAK2 V617F mutation, along with its effects on cell proliferation and apoptosis. MethodsThe JAK2 V617F mutation was identified using reverse transcription PCR and gene sequencing...
March 2024: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://read.qxmd.com/read/38512029/-prunetin-inhibits-tlr4-myd88-pathway-to-attenuate-intestinal-epithelial-inflammatory-response-and-ameliorate-mouse-crohn-s-disease-like-colitis
#35
JOURNAL ARTICLE
Jing Li, Yang Sun, Xinyu Xiong, Minda Wang, Lugen Zuo, Yueyue Wang, Zhijun Geng
Objective To investigate the regulatory role of natural plant compound prunetin (PRU) on the intestinal epithelial inflammation and the barrier structure in Crohn's disease-like colitis. Methods A lipopolysaccharide (LPS)-induced inflammatory injury model of colonic organoids and a 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced mouse colitis model were established to evaluate the effects of PRU on the intestinal epithelial inflammation and intestinal barrier. In addition, network pharmacological predictions, combined with in vitro and in vivo studies, were used to analyze the molecular mechanisms by which PRU modulates intestinal epithelial inflammation and intestinal barrier in CD-like colitis...
March 2024: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://read.qxmd.com/read/38512028/-il-1%C3%AE-inhibits-macrophage-m2-polarization-by-down-regulating-cd200-expression-in-human-umbilical-cord-mesenchymal-stem-cells
#36
JOURNAL ARTICLE
Yongzhao Zhu, Li Li, Zheng Wang, Xipeng Tan, Jin Tao, Lu Ding, Hui Dong, Peng Ye
Objective To investigate the regulation of IL-1β on the expression of CD200 in human umbilical cord mesenchymal stem cells (hUC-MSCs), its role in macrophage polarization and the underlying mechanism. Methods hUC-MSCs were isolated and cultured in serum-free medium. Morphological observation and the expressions of CD73, CD90, CD105, CD14, CD34, CD45 and HLA-DR were detected by flow cytometry to confirm the properties of mesenchymal stem cells. hUC-MSCs were treated with IL-1β at the final concentration of 20 ng/mL for 24 hours...
March 2024: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://read.qxmd.com/read/38509863/cdc2-plasticity-and-acquisition-of-a-dc3-like-phenotype-mediated-by-il-6-and-pge2-in-a-patient-derived-colorectal-cancer-organoids-model
#37
JOURNAL ARTICLE
Beatriz Subtil, Iris A E van der Hoorn, Jorge Cuenca-Escalona, Anouk M D Becker, Mar Alvarez-Begue, Kirti K Iyer, Jorien Janssen, Tom van Oorschot, Dennis Poel, Mark A J Gorris, Koen van den Dries, Alessandra Cambi, Daniele V F Tauriello, I Jolanda M de Vries
Metastatic colorectal cancer (CRC) is highly resistant to therapy and prone to recur. The tumor-induced local and systemic immunosuppression allows cancer cells to evade immunosurveillance, facilitating their proliferation and dissemination. Dendritic cells (DCs) are required for the detection, processing, and presentation of tumor antigens, and subsequently for the activation of antigen-specific T cells to orchestrate an effective antitumor response. Notably, successful tumors have evolved mechanisms to disrupt and impair DC functions, underlining the key role of tumor-induced DC dysfunction in promoting tumor growth, metastasis initiation, and treatment resistance...
March 21, 2024: European Journal of Immunology
https://read.qxmd.com/read/38508337/utilization-of-protocols-to-lower-daily-aspirin-dose-prior-to-surgical-procedures-for-patients-with-aspirin-exacerbated-respiratory-disease
#38
JOURNAL ARTICLE
Rose C Corcoran, Laura B Bailey, Alyson N Brown, Kathleen M Buchheit, Jillian C Bensko, Tanya M Laidlaw
No abstract text is available yet for this article.
March 18, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38508336/gaps-in-care-among-uncontrolled-severe-asthma-patients-in-the-united-states
#39
JOURNAL ARTICLE
Tara Carr, Joseph Tkacz, Yen Chung, Christopher S Ambrose, Joseph Spahn, Pallavi Rane, Yan Wang, Andrew W Lindsley, Benjamin Lewing, Autumn Burnette
BACKGROUND: Understanding the implementation of key guideline recommendations is critical for management of severe asthma (SA) in the treatment of uncontrolled disease. OBJECTIVE: To assess specialist visits and medication escalation in US patients with SA following events indicating-uncontrolled-disease (EUD) and associations with health outcomes and social disparity indicators. METHODS: SA patients appearing in administrative claims data spanning 2015-2020 were indexed hierarchically on asthma-related EUD, including hospitalizations, emergency department visits with systemic corticosteroid treatment (SCS), or outpatient visits with SCS...
March 18, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38508295/type-i-interferon-associated-epistasis-may-contribute-to-early-disease-onset-and-high-disease-activity-in-juvenile-onset-lupus
#40
REVIEW
Yves Renaudineau, Amandine Charras, Valentina Natoli, Mathieu Fusaro, Eve M D Smith, Michael W Beresford, Christian M Hedrich
Pathologic type I interferon (T1IFN) expression is a key feature in systemic lupus erythematosus (SLE) that associates with disease activity. When compared to adult-onset disease, juvenile-onset (j)SLE is characterized by increased disease activity and damage, which likely relates to increased genetic burden. To identify T1IFN-associated gene polymorphisms (TLR7, IRAK1, miR-3142/miR-146a, IRF5, IRF7, IFIH1, IRF8, TYK2, STAT4), identify long-range linkage disequilibrium and gene:gene interrelations, 319 jSLE patients were genotyped using panel sequencing...
March 18, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
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