keyword
https://read.qxmd.com/read/38431238/maternal-immune-activation-and-estrogen-receptor-modulation-induce-sex-specific-dopamine-related-behavioural-and-molecular-alterations-in-adult-rat-offspring
#1
JOURNAL ARTICLE
Sophie R Debs, Illya Conn, Brendan Navaneethan, Andriane G Penklis, Urs Meyer, Simon Killcross, Cynthia Shannon Weickert, Tertia D Purves-Tyson
Dopamine dysregulation contributes to psychosis and cognitive deficits in schizophrenia that can be modelled in rodents by inducing maternal immune activation (MIA). The selective estrogen receptor (ER) modulator, raloxifene, can improve psychosis and cognition in men and women with schizophrenia. However, few studies have examined how raloxifene may exert its therapeutic effects in mammalian brain in both sexes during young adulthood (age relevant to most prevalent age at diagnosis). Here, we tested the extent to which raloxifene alters dopamine-related behaviours and brain transcripts in young adult rats, both control and MIA-exposed females and males...
February 29, 2024: Brain, Behavior, and Immunity
https://read.qxmd.com/read/37337486/corticosteroid-induced-psychosis-a-report-of-three-cases
#2
Anil K Bachu, Victoria Davis, Mouad Abdulrahim, Lauren Harbaugh, Sakshi Prasad, Vijaya Padma Kotapati, Sushma Srinivas
Corticosteroids are commonly used for pain management and inflammatory conditions but can cause neuropsychiatric complications ranging from anxiety to severe mood and psychotic symptoms. These complications can occur shortly after steroid treatment begins or at any point during therapy, and even after treatment has stopped. We present three cases of corticosteroid-induced psychosis in patients being treated for pain. The mechanism behind these complications is not fully understood, but stress on the hypothalamic-pituitary-adrenal (HPA) axis is thought to play a role...
May 2023: Curēus
https://read.qxmd.com/read/37200642/the-association-between-prolonged-use-of-oral-corticosteroids-and-mental-disorders-do-steroids-have-a-role-in-developing-mental-disorders
#3
JOURNAL ARTICLE
Mouath A Alturaymi, Omar F Almadhi, Yazeed S Alageel, Majed Bin Dayel, Mohammed S Alsubayyil, Badr F Alkhateeb
Background The use of oral corticosteroids has been linked to a variety of mental health problems, including mental disorders such as anxiety, depression, and psychosis. In a recent study, researchers investigated the prevalence of steroid-induced neuropsychiatric side effects in a population of patients receiving steroid treatment. This study aimed to evaluate the association between steroids and mental disorders among patients in King Abdulaziz Medical City. Methods A retrospective descriptive study was conducted in King Abdulaziz Medical City, Riyadh, Saudi Arabia from January 2016 to November 2022...
April 2023: Curēus
https://read.qxmd.com/read/37200146/acute-mania-in-a-patient-with-primary-adrenal-insufficiency-due-to-autoimmune-adrenalitis-a-case-report
#4
JOURNAL ARTICLE
Nolan J Brown, Alex Wang, Gianna Fote, Chris Gabriel, Reza Farokhpay, John Luo
We describe a rare case of acute mania in the setting of autoimmune adrenalitis. A 41-year-old male with no previous psychiatric diagnoses presented with impulsivity, grandiosity, delusions of telepathy, and hyperreligiosity following a previous hospitalization for an acute adrenal crisis and 2 subsequent days of low-dose corticosteroid treatment. Workups for encephalopathy and lupus cerebritis were negative, raising concern that this presentation might represent steroid-induced psychosis. However, discontinuation of corticosteroids for 5 days did not resolve the patient's manic episode, suggesting that his clinical presentation was more likely new onset of a primary mood disorder or a psychiatric manifestation of adrenal insufficiency itself...
May 1, 2023: Journal of Psychiatric Practice
https://read.qxmd.com/read/37074331/glucocorticoid-induced-psychosis-in-children-and-adolescents-a-systematic-review
#5
REVIEW
Parisa Fani-Molky, Jarrod Bradley, Mark S Cooper
Objectives: Knowledge is limited regarding the adverse effects of therapeutic glucocorticoids on pediatric mental health outcomes. Glucocorticoid-induced psychosis (GIP) is a rare but severe side effect of high-dose glucocorticoid therapy in children and adolescents. This study identified reported pediatric cases of GIP, based on DSM-5 criteria, and defined its presentation, treatments, and outcomes. Methods: A systematic review was completed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, including pediatric patients with incident psychosis following glucocorticoid treatment...
April 2023: Journal of Child and Adolescent Psychopharmacology
https://read.qxmd.com/read/36733547/the-rationale-for-using-corticosteroids-in-covid-19-encephalopathy-lessons-from-a-case-report-with-evidence-from-literature
#6
Muhammad Atif Ameer, Haroon Chaudhry, Maham Babar, Nimi Patel, Monata Song, Mathew Mathew
The coronavirus disease 2019 (COVID-19) virus primarily affects the pulmonary system, but neurological manifestations and complication of COVID-19 has been reported in abundance in the literature. We present a case of a middle-aged Caucasian male who was brought to the emergency department for altered mental status. His chief complaints were neurological rather than respiratory. A positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcription polymerase chain reaction (RT-PCR) nasal swab confirmed the diagnosis...
January 2023: Curēus
https://read.qxmd.com/read/36582883/psychotic-symptoms-in-a-patient-with-systemic-lupus-erythematosus-a-diagnostic-dilemma-between-lupus-psychosis-and-steroid-induced-psychosis
#7
Bishnu Deep Pathak, Binit Upadhaya Regmi, Bishal Dhakal, Sushil Joshi, Nabin Simkhada, Suhail Sapkota, Sushant Joshi, Sujan Rana Thapa
INTRODUCTION: Systemic Lupus Erythematosus (SLE) is a chronic auto-immune disorder with the involvement of multiple organ systems. It is more common in females. CASE PRESENTATION: Here, we present a case of 12-year-old female, known case of SLE with lupus nephritis, presenting with neuropsychiatric symptoms. She was under steroids as well for a few weeks due to flare-up of symptoms prior to that. Due to this, there was a diagnostic dilemma between lupus psychosis and steroid induced psychosis...
December 2022: Annals of Medicine and Surgery
https://read.qxmd.com/read/36291231/food-restriction-counteracts-dexamethasone-induced-downregulation-of-genes-involved-in-cholesterol-homeostasis-in-rat-brain-during-aging
#8
JOURNAL ARTICLE
Jelena Ciric, Vesna Tesic, Nikola Milovanovic, Irena Jovanovic Macura, Sanja Ivkovic, Selma Kanazir, Milka Perovic
Glucocorticoids are the most potent anti-inflammatory agents known. Limited in vivo data are available to characterize the mechanism underlying their cognitive side effects and transient occurrence of steroid psychosis. Cholesterol is important for proper neurotransmission and brain plasticity, and disruption of its homeostasis in the brain has been closely associated with memory decline during aging and in age-related neurodegenerative disorders. In the present study, we assessed the direct effects of dexamethasone, a potent synthetic glucocorticoid, on the expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), apolipoprotein E (ApoE) and cholesterol 24S-hydroxylase (CYP46A1), major enzymes involved in cholesterol synthesis, metabolism, and excretion, respectively...
September 26, 2022: Brain Sciences
https://read.qxmd.com/read/36254327/myocarditis-following-immune-checkpoint-inhibition-with-pembrolizumab-management-in-a-context-of-steroid-intolerance
#9
Laura L Onderko, Ross Heinrich, Katalin Gosling, Tim Downs, Maxwell Eyram Afari
Immune checkpoint inhibitors (ICIs) are a major advance in oncology and have become first- or second-line therapy for over 50% of oncology patients. ICI-associated myocarditis is a complication that, although rare, has a high mortality rate. We present a case of ICI-associated myocarditis presenting as complete heart block. Traditional treatment with high-dose steroids was abandoned in this case, owing to steroid-induced psychosis. Alternative treatment with immunomodulators was initiated with a good response...
October 2022: CJC open
https://read.qxmd.com/read/36147063/steroid-induced-psychosis-in-a-child-with-nephrotic-syndrome-a-case-report
#10
Amrit Bhusal, Silan Bhandari, Sagar Pokhrel, Shankar Prasad Yadav
Background: and Importance: Steroids induced psychosis is one of major adverse effects of corticosteroids therapy especially in patients with disease causing low serum albumin level like nephrotic syndrome. The literature review about this adverse effects is lesser in children than adults population. The management is done by tapering dose of steroids in aid of immunosuppressive drug with an antipsychotics drug. Case presentation: Here we present a case of 14 years old female child known case of nephrotic syndrome secondary to Focal segmental glomerulosclerosis with steroids induced psychosis who is managed by tapering dose of prednisolone with Tacrolimus as immunosuppressive and Quetiapine as antipsychotic...
September 2022: Annals of Medicine and Surgery
https://read.qxmd.com/read/36074112/acute-onset-psychosis-with-mystical-delusions-in-a-young-male-patient-following-discontinuation-of-corticosteroid-therapy-a-case-report
#11
JOURNAL ARTICLE
Giuseppe Bartolomei, Luca Lorenzini, Maria Martelli, Eleonora Gambaro, Patrizia Zeppegno, Carla Gramaglia
Corticosteroid-based drugs are widely used in the general population to treat several acute and chronic inflammatory conditions. However, the therapeutic efficacy of these drugs is often accompanied by severe psychiatric adverse effects through a yet unknown mechanism. To further complicate this situation, therapeutic strategies to counteract psychotic symptoms associated with these agents have yet to be devised. We report a case of a young white male Jehovah's Witness admitted to the psychiatry ward of the Maggiore della Carità Hospital, Novara, Italy...
September 1, 2022: Journal of Psychiatric Practice
https://read.qxmd.com/read/35755003/mania-as-a-rare-adverse-event-secondary-to-steroid-eye-drops
#12
Moayyad Alsalem, Majed A Alharbi, Rayan A Alshareef, Raghad Khorshid, Salman Thabet, Abdulrahman Alghamdi
Since glucocorticoids (GCs) were introduced for the treatment of various diseases, they have been linked with the development of psychiatric adverse effects such as mania, depression, and psychosis. These behavioral or psychiatric adverse events usually appear within a few days after commencing GCs and are possibly to reverse with drug withdrawal. We present a rare case of a 75-year-old woman who developed mania during treatment with GC eye drops following cataract surgery. Management consisted of discontinuing prednisolone and administering olanzapine, which resulted in full recovery in a week...
2022: Case Reports in Psychiatry
https://read.qxmd.com/read/35747766/an-immunologic-storm-a-case-of-encephalitis-and-thrombotic-thrombocytopenic-purpura-with-underlying-likely-sjogren-s-syndrome-induced-by-a-covid-19-immune-response
#13
Brittany M Kasturiarachi, Diana L Alsbrook, Jennifer Crook, Namrata Shah
Introduction: There are rare cases of Sjogren's syndrome presenting with manifestations of encephalitis. There are also rare patients with Sjogren's presenting with acute thrombotic thrombocytopenic purpura (TTP). There are no cases of both occurring together as the only symptoms of the syndrome. During the COVID-19 pandemic, more cases of autoimmunity are being described given its robust immune response. It is important to keep a wide differential about these varying clinical presentations...
July 2022: Neurohospitalist
https://read.qxmd.com/read/35602375/management-of-psychiatric-disorders-in-patients-with-endocrine-disorders
#14
JOURNAL ARTICLE
Kshirod Kumar Mishra, Neena Sawant, Shobit Garg
The neuropsychiatric symptoms and disorders among endocrine disorders are discussed in the context of current global and local epidemiological data. Neuropsychiatric symptoms, clinical differentials in hypothyroidism, hyperthyroidism, and parathyroid disorders, and relevant management protocols are described. HPT axis and its interaction with psychotropic usage are mentioned. Stress diathesis, depression, anxiety disorders, and severe mental illnesses and their respective association with diabetes, the relevant mechanisms, and management protocols are stated...
March 2022: Indian Journal of Psychiatry
https://read.qxmd.com/read/35467605/medication-induced-psychotic-disorder-a-review-of-selected-drugs-side-effects
#15
REVIEW
Anna Niebrzydowska, Jakub Grabowski
BACKGROUND: Medication-induced psychotic disorder (MIPD) is a diagnostic term for a syndrome with symptoms such as hallucinations and delusions directly related to drug intake. The purpose of this review is to report and comment on the current knowledge about pathomechanisms, risk factors, symptoms, and treatment of MIPD caused by selected widely used medications. METHODS: PubMed, Scopus, and Google Scholar databases were searched for articles on MIPD published prior to January 2021 using search terms 'psychosis' OR 'psychotic disorder' AND 'side effects' combined with certain medications group...
2022: Psychiatria Danubina
https://read.qxmd.com/read/35399095/a-challenging-case-of-an-adolescent-and-young-adult-patient-with-high-risk-acute-lymphoblastic-leukemia-the-need-for-a-multidisciplinary-approach-a-case-report
#16
JOURNAL ARTICLE
Izabela Kranjčec, Nuša Matijašić, Slaven Abdović, Iva Hižar Gašpar, Lavinia La Grasta Sabolić, Filip Jadrijević-Cvrlje
BACKGROUND: Adolescents and young adults diagnosed with acute lymphoblastic leukemia are treated according to pediatric-based regimens to achieve better results. However, implementation of intensive chemotherapy protocols in this age group is associated with increased treatment-related toxicities, affecting almost every organ and system. In this case, the focus of our interest was on rather rare entities: steroid-induced psychosis that seldom develops in children and adolescents, and choroid plexus hemosiderosis, infrequently identified as a first sign of iron overload...
April 11, 2022: Journal of Medical Case Reports
https://read.qxmd.com/read/35373091/glucocorticoid-therapy-in-anca-vasculitis-using-the-glucocorticoid-toxicity-index-as-an-outcome-measure
#17
JOURNAL ARTICLE
Lauren Floyd, Adam Morris, Miland Joshi, Ajay Dhaygude
Background: ANCA-associated vasculitis (AAV) is an autoimmune disease. Induction remission and maintenance treatment typically includes high-dose, tapering glucocorticoids (GC), in addition to other immunosuppressive medication. The use of theGlucocorticoid Toxicity Index (GTI) provides a global, quantifiable assessment tool in which clinicians can assess GC-associated morbidity. Recent trials in AAV have exposed the need for systemic assessment of GC burden. In this small cohort study, we look to address these issues and the justification of newer GC sparing agents, such as C5a inhibitors...
June 24, 2021: Kidney360
https://read.qxmd.com/read/35141097/four-case-reports-of-acute-psychosis-secondary-to-low-doses-of-prednisone-prednisolone
#18
Aquila Lesko, Naciye Kalafat, Maleeha Afreen
Prednisone, the prodrug of prednisolone, has been implicated as the cause of neuropsychiatric symptoms such as depression, mania, agitation, delirium, dementia, psychosis, and many other affective, behavioral, and cognitive changes. Although the literature suggests that patients on 40 mg or more of prednisone a day are at a greater risk for steroid-induced psychosis, patients on <40 mg are still at risk, and therefore, steroid-induced psychosis should not be excluded from the differential. Prednisone is the prodrug of prednisolone, and the two are comparable on a milligram (mg)-to-mg basis...
December 2021: Curēus
https://read.qxmd.com/read/35006131/p001-corticosteroid-induced-mood-changes-in-ibd
#19
JOURNAL ARTICLE
Rachel Gora
BACKGROUND: Depression and anxiety have been identified as symptoms of inflammatory bowel disease (IBD). An association between disease severity and depressive symptoms has been observed. Corticosteroids are used to treat IBD flares but frequently causes neuropsychiatric adverse effects that are expressed as hypomania, anxiety, and psychosis. There is a gap in literature pertaining to the effect of steroids on mood changes in patients with IBD. This scholarly research project aims to investigate this relationship...
December 1, 2021: American Journal of Gastroenterology
https://read.qxmd.com/read/34752563/pharmacological-management-of-steroid-induced-psychosis-a-review-of-patient-cases
#20
REVIEW
Grace Huynh, Justin P Reinert
Objective: To review the efficacy and safety of medications used in the management of steroid-induced psychosis. Data Sources: A comprehensive literature search was conducted using PubMed, MEDLINE, ProQuest, and Scopus between May and October 2020 using the following search terminology: "steroid-induced psychosis" OR "corticosteroid-induced psychosis." Study Selection and Data Extraction: Definitive cases, as defined by the Diagnostic and Statistical Manual of Mental Disorders, 5th edition , were included in this review...
April 2021: Journal of Pharmacy Technology: JPT: Official Publication of the Association of Pharmacy Technicians
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