Wasita W Parksook, Jenifer M Brown, Kei Omata, Yuta Tezuka, Yoshikiyo Ono, Fumitoshi Satoh, Laura C Tsai, Yvonne Niebuhr, Julia Milks, Anna Moore, Brooke Honzel, Haiping Liu, Richard J Auchus, Sarat Sunthornyothin, Adina F Turcu, Anand Vaidya
CONTEXT: Primary aldosteronism is a form of low-renin hypertension characterized by dysregulated aldosterone production. OBJECTIVE: To investigate the contributions of renin-independent aldosteronism, and ACTH-mediated aldosteronism, in individuals with a low-renin phenotype representing the entire continuum of blood pressure.. DESIGN/PARTICIPANTS: Human physiology study of 348 participants with a low-renin phenotype with severe and/or resistant hypertension, hypertension with hypokalemia, elevated blood pressure and stage I/II hypertension, and normal blood pressure...
March 7, 2024: Journal of Clinical Endocrinology and Metabolism