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https://www.readbyqxmd.com/read/28643621/linoleic-acid-%C3%AE-linolenic-acid-and-enterolactone-affect-lipid-oxidation-and-expression-of-lipid-metabolism-and-antioxidant-related-genes-in-hepatic-tissue-of-dairy-cows
#1
Émilie Fortin, Richard Blouin, Jérôme Lapointe, Hélène V Petit, Marie-France Palin
Although beneficial effects have been attributed to PUFA supplementation in high-yielding dairy cows, diets rich in PUFA may also increase oxidative stress in tissues such as the liver. To fully exploit the health benefits of PUFA, we believe that the addition of natural antioxidants could help in preventing oxidative damage. Using an in vitro precision-cut liver slices (PCLS) tissue culture system, we investigated the effects of different linoleic acid (LA, n-6):α-linolenic acid (ALA, n-3) ratios (LA:ALA ratio of 4, LA:ALA ratio of 15 and LA:ALA ratio of 25) in the presence or absence of the antioxidant enterolactone (ENL) on (1) the mRNA abundance of genes with key roles in hepatic lipid metabolism, oxidative stress response and inflammatory processes, (2) oxidative damages to lipids and proteins and (3) superoxide dismutase activity in early-lactating dairy cows...
May 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28638275/the-application-of-dehydroepiandrosterone-on-improving-mitochondrial-function-and-reducing-apoptosis-of-cumulus-cells-in-poor-ovarian-responders
#2
Li-Te Lin, Peng-Hui Wang, Zhi-Hong Wen, Chia-Jung Li, San-Nung Chen, Eing-Mei Tsai, Jiin-Tsuey Cheng, Kuan-Hao Tsui
Poor ovarian responders (PORs) pose a great challenge for in vitro fertilization (IVF). Previous studies have suggested that dehydroepiandrosterone (DHEA) may improve IVF outcomes in PORs. The current study attempted to investigate the clinical benefits of DHEA in PORs and the possible mechanisms of DHEA on cumulus cells (CCs). This was a prospective study performed at one tertiary center from January 2015 to March 2016. A total of 131 women who underwent IVF treatment participated, including 59 normal ovarian responders (NORs) and 72 PORs...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28632430/hematopoietic-developmental-potential-of-human-pluripotent-stem-cell-lines-is-accompanied-by-the-morphology-of-embryoid-bodies-and-the-expression-of-endodermal-and-hematopoietic-markers
#3
Lenka Tesarova, Pavel Simara, Stanislav Stejskal, Irena Koutna
The potential clinical applications of hematopoietic stem cells (HSCs) derived from human pluripotent stem cells (hPSCs) are limited by the difficulty of recapitulating embryoid hematopoiesis and by the unknown differentiation potential of hPSC lines. To evaluate their hematopoietic developmental potential, available hPSC lines were differentiated by an embryoid body (EB) suspension culture in serum-free medium supplemented with three different cytokine mixes (CMs). The hPSC differentiation status was investigated by the flow cytometry expression profiles of cell surface molecules, and the gene expression of pluripotency and differentiation markers over time was evaluated by real-time reverse transcription polymerase chain reaction (qRT-PCR)...
June 20, 2017: Cellular Reprogramming
https://www.readbyqxmd.com/read/28630448/progesterone-prevents-epithelial-mesenchymal-transition-of-ovine-amniotic-epithelial-cells-and-enhances-their-immunomodulatory-properties
#4
Angelo Canciello, Valentina Russo, Paolo Berardinelli, Nicola Bernabò, Aurelio Muttini, Mauro Mattioli, Barbara Barboni
The in vitro expansion is detrimental to therapeutic applications of amniotic epithelial cells (AEC), an emerging source of fetal stem cells. This study provides molecular evidences of progesterone (P4) role in preventing epithelial-mesenchymal transition (EMT) in ovine AEC (oAEC). oAEC amplified under standard conditions spontaneously acquired mesenchymal properties through the up-regulation of EMT-transcription factors. P4 supplementation prevented phenotype shift by inhibiting the EMT-inducing mechanism such as the autocrine production of TGF-β and the activation of intracellular-related signaling...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28630042/the-glutamate-cystine-antiporter-slc7a11-xct-enhances-cancer-cell-dependency-on-glucose-by-exporting-glutamate
#5
Pranavi Koppula, Yilei Zhang, Jiejun Shi, Wei Li, Boyi Gan
Cancer cells with specific genetic alterations may be highly dependent on certain nutrients for survival, which can inform therapeutic strategies to target these cancer-specific metabolic vulnerabilities. The glutamate/cystine antiporter solute carrier family 7 member 11 (SLC7A11, also called xCT) is overexpressed in several cancers. Contrasting the established pro-survival roles of SLC7A11 under other stress conditions, here we report an unexpected finding that SLC7A11 overexpression enhances cancer cell dependency on glucose and renders cancer cells more sensitive to glucose starvation-induced cell death, and conversely, that SLC7A11 deficiency by either knockdown or pharmacological inhibition promotes cancer cell survival upon glucose starvation...
June 19, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28618962/amelioration-of-dalton-s-lymphoma-induced-angiogenesis-by-melatonin
#6
Rani Kumari, Kavita Rawat, Anupma Kumari, Anju Shrivastava
For tumor to grow beyond 1-2 mm(3) size, tumor recruits new blood vessels referred as angiogenesis; therefore, targeting angiogenesis can be a promising strategy to suppress cancer progression. In this study, in order to develop a good angiogenesis model, we investigated effect of Dalton's lymphoma on angiogenesis and further monitored the role of melatonin on regulation of angiogenesis. To evaluate angiogenesis, endothelial cells were isolated from main thoracic aorta and cultured in vitro in the presence or absence of Dalton's lymphoma supplemented with or without melatonin to monitor their role on its proliferation and migration, a hallmark of angiogenesis...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28617821/supplementation-with-small-extracellular-vesicles-from-ovarian-follicular-fluid-during-in-vitro-production-modulates-bovine-embryo-development
#7
Juliano C da Silveira, Gabriella M Andrade, Maite Del Collado, Rafael V Sampaio, Juliano R Sangalli, Luciano A Silva, Fábio V L Pinaffi, Izabelle B Jardim, Marcelo C Cesar, Marcelo F G Nogueira, Aline S M Cesar, Luiz L Coutinho, Rinaldo W Pereira, Felipe Perecin, Flávio V Meirelles
Pregnancy success results from the interaction of multiple factors, among them are folliculogenesis and early embryonic development. Failure during these different processes can lead to difficulties in conception. Alternatives to overcome these problems are based on assisted reproductive techniques. Extracellular vesicles are cell-secreted vesicles present in different body fluids and contain bioactive materials, such as messenger RNA, microRNAs (miRNAs), and proteins. Thus, our hypothesis is that extracellular vesicles from follicular fluid from 3-6 mm ovarian follicles can modulate bovine embryo development in vitro...
2017: PloS One
https://www.readbyqxmd.com/read/28601894/lichenysin-production-is-improved-in-cody-null-bacillus-licheniformis-by-addition-of-precursor-amino-acids
#8
Chengjun Zhu, Fang Xiao, Yimin Qiu, Qin Wang, Zhili He, Shouwen Chen
Lichenysin is categorized into the family of lipopeptide biosurfactants and has a variety of applications in the petroleum industry, bioremediation, pharmaceuticals, and the food industry. Currently, large-scale production is limited due to the low yield. This study found that lichenysin production was repressed by supplementation of extracellular amino acids. The global transcriptional factor CodY was hypothesized to prevent lichenysin biosynthesis under an amino acid-rich condition in Bacillus licheniformis...
June 11, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28601635/silencing-hif-1%C3%AE-induces-tet2-expression-and-augments-ascorbic-acid-induced-5-hydroxymethylation-of-dna-in-human-metastatic-melanoma-cells
#9
Adam P Fischer, Sarah L Miles
Expression and function of Ten-eleven translocation (TET) enzymes, which initiate DNA demethylation by catalyzing the oxidation of 5-methylcytosine to 5-hydroxymethylcytosine (5 hmC) on methylated DNA, are frequently lost in malignant tissue. This ultimately results in lost expression of methylated tumor suppressor genes. Many malignancies, including melanoma, also aberrantly overexpress the oncogenic hypoxia inducible factor-1α (HIF-1α) transcription factor, however the association between HIF-1α and TET enzyme expression is largely uninvestigated...
June 7, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28601148/leptin-supplementation-in%C3%A2-vitro-improved-developmental-competence-of-buffalo-oocytes-and-embryos
#10
Bibhudatta S K Panda, Sriti Pandey, Anjali Somal, Mehtab S Parmar, Irfan A Bhat, Indu Baiju, Mukesh K Bharti, G Sai Kumar, Vikash Chandra, G Taru Sharma
The aim of the present study was to determine potential role of leptin on in vitro developmental competence of buffalo oocytes and embryos. Slaughterhouse derived culture grade buffalo cumulus oocyte complexes (COCs) were matured in vitro (IVM) with leptin (10 ng/ml) or without leptin (control). In each experiment, a pool of matured COCs was used for further in vitro embryo production and another pool of COCs was used for cumulus cells and mature oocytes isolation to study the relative mRNA expression of developmentally important genes...
August 2017: Theriogenology
https://www.readbyqxmd.com/read/28599877/zeaxanthin-improves-diabetes-induced-cognitive-deficit-in-rats-through-activiting-pi3k-akt-signaling-pathway
#11
Xiaoyan Zhou, Shanshan Wang, Xin Ding, Li Qin, Yizhen Mao, Lei Chen, Wei Li, Changjiang Ying
Published studies have shown that cognitive deficit is a characteristic manifestation of neurodegenerative disease in diabetes. However, there is no effective prevention and treatment for this diabetes-associated behavior disorder. In the present study, we attempted to elucidate the effect of zeaxanthin on cognitive deficit and the change in the hippocampus correlated with cognitive decline in diabetic rats. Diabetic rats in this study were induced by high-fat diet and low-dose streptozocin (STZ), cognitive ability of rats were evaluated use morris water maze (MWM) and morphology change in hippocampus was assessed by cresyl violet stain...
June 10, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28598237/homocysteine-as-a-diagnostic-and-etiopathogenic-factor-in-children-with-autism-spectrum-disorder
#12
Jan Józefczuk, Wiktoria Kasprzycka, Rafał Czarnecki, Alfreda Graczyk, Paweł Józefczuk, Krzysztof Magda, Urszula Lampart
Substantial characteristics of autism are cognitive and psychophysical disorders. Etiopathogenetic factors are thought to be responsible for development of autism in children with genetic predisposition as well as have their effect on the severity of the disorders. The main problem of early identification of patients affected by autism spectrum disorder is that there are no clear diagnostic criteria. The aim of our study was assessment of hair magnesium and serum homocysteine concentrations in children with autism...
June 9, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28589421/tat-myod-fused-proteins-together-with-c2c12-conditioned-medium-are-able-to-induce-equine-adult-mesenchimal-stem-cells-towards-the-myogenic-fate
#13
Marco Patruno, Chiara Gomiero, Roberta Sacchetto, Ohad Topel, Alessandro Negro, Tiziana Martinello
The Tat protein is able to translocate through the plasma membrane and when it is fused with other peptides may acts as a protein transduction system. This ability appears particularly interesting to induce tissue-specific differentiation when the Tat protein is associated to transcription factors. In the present work, the potential of the complex Tat-MyoD in inducing equine peripheral blood mesenchymal stem cells (PB-MSCs) towards the myogenic fate, was evaluated. Results showed that the internalization process of Tat-MyoD happens only in serum free conditions and that the nuclear localization of the fused complex is observed after 15 hours of incubation...
June 6, 2017: Veterinary Research Communications
https://www.readbyqxmd.com/read/28578257/melatonin-supplementation-plus-exercise-behavior-ameliorate-insulin-resistance-hypertension-and-fatigue-in-a-rat-model-of-type-2-diabetes-mellitus
#14
Md Mahbubur Rahman, Han-Sol Kwon, Myung-Jin Kim, Hyeon-Kyu Go, Min-Ho Oak, Do-Hyung Kim
INTRODUCTION: The objective was to investigate the effects of melatonin and exercise on insulin resistance (IR), hypertension and fatigue syndrome in a rat model of type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: Rats were divided into 5 groups namely normal control (NC), T2DM control group (DC), diabetes plus exercise (DE), diabetes plus oral melatonin supplement (DM) and diabetes plus melatonin and exercise (DME) groups. Melatonin was administered orally 5mg/kg twice daily and 40min swimming/day 5days/week were regimented after diabetes induction...
August 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28570634/neuroprotective-effect-of-bilberry-extract-in-a-murine-model-of-photo-stressed-retina
#15
Hideto Osada, Tomohiro Okamoto, Hirohiko Kawashima, Eriko Toda, Seiji Miyake, Norihiro Nagai, Saori Kobayashi, Kazuo Tsubota, Yoko Ozawa
Excessive exposure to light promotes degenerative and blinding retinal diseases such as age-related macular degeneration and retinitis pigmentosa. However, the underlying mechanisms of photo-induced retinal degeneration are not fully understood, and a generalizable preventive intervention has not been proposed. Bilberry extract is an antioxidant-rich supplement that ameliorates ocular symptoms. However, its effects on photo-stressed retinas have not been clarified. In this study, we examined the neuroprotective effects of bilberry extract against photo-stress in murine retinas...
2017: PloS One
https://www.readbyqxmd.com/read/28566583/bergamottin-promotes-adipocyte-differentiation-and-inhibits-tumor-necrosis-factor-%C3%AE-induced-inflammatory-cytokines-induction-in-3t3-l1-cells
#16
Hideya Mizuno, Tomoko Hatano, Ayako Taketomi, Mami Kawabata, Toshikatsu Nakabayashi
 Nowadays, a lot of food ingredients are marketed as dietary supplements for health. Because the effectiveness and mechanisms of these compounds have not been fully characterized, they might have unknown functions. Therefore, we investigated the effect of several food ingredients (Bergamottin, Chrysin, L-Citrulline and β-Carotene) known as health foods on adipocyte differentiation by using 3T3-L1 preadipocytes. In this study, we found that Bergamottin, a furanocoumarin isolated from grapefruit juice, promotes adipocyte differentiation...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28558369/long-non-coding-rna-expression-profiling-in-obesity-mice-with-folic-acid-supplement
#17
Feifei Ma, Wei Li, Renqiao Tang, Zhuo Liu, Shengrong Ouyang, Dingding Cao, Yuanyuan Li, Jianxin Wu
BACKGROUND/AIMS: Obesity is a major contributor to the growing prevalence of metabolic and cardiovascular diseases. This study was designed to investigate the effect of folic acid (FA) on obese mice by detecting the genome-wide expression profile of lncRNAs and mRNAs in the heart. METHODS: Heart samples were collected from mice fed with standard diet (SD), high-fat diet (HFD) and high-fat diet with FA intake (HFDF). LncRNAs and mRNAs between HFD and HFDF group were analyzed by lncRNA microarray...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28556544/pituicytoma-an-outlook-on-possible-targeted-therapies
#18
Klaus Christian Mende, Jakob Matschke, Till Burkhardt, Wolfgang Saeger, Rolf Buslei, Michael Buchfelder, Rudolf Fahlbusch, Manfred Westphal, Jörg Flitsch
INTRODUCTION: Pituicytoma is a rare neoplasm of the sella region. Tumor resection is the primary treatment option, but remains subtotal due to excessive bleeding in many cases. The search for alternative or additional treatment regimens is necessary. AIMS: We aimed to determine the receptor expression of pituicytoma to find alternatives or supplements to surgical therapy in the use of targeted therapies. METHODS: Pituicytoma samples were collected from three institutions between 2006 and 2015 and were stained for vascular endothelial growth factors (VEGF), thyroid transcription factor (TTF1), and somatostatin receptors (SSTR 2/3/5)...
July 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28553272/rpon-promotes-pseudomonas-aeruginosa-survival-in-the-presence-of-tobramycin
#19
Darija Viducic, Keiji Murakami, Takashi Amoh, Tsuneko Ono, Yoichiro Miyake
Pseudomonas aeruginosa has developed diverse strategies to respond and adapt to antibiotic stress. Among the factors that modulate survival in the presence of antibiotics, alternative sigma factors play an important role. Here, we demonstrate that the alternative sigma factor RpoN (σ(54)) promotes survival in the presence of tobramycin. The tobramycin-sensitive phenotype of logarithmic phase ΔrpoN mutant cells is suppressed by the loss of the alternative sigma factor RpoS. Transcriptional analysis indicated that RpoN positively regulates the expression of RsmA, an RNA-binding protein, in the P...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28551191/a-commercial-immune-modulating-feed-additive-restores-l-selectin-and-ccl5-expression-following-dexamethasone-treatment-of-murine-immune-cells-in-a-myd88-dependent-manner
#20
R J Ortiz-Marty, A Lewandowski, J D Chapman, I Kanevsky-Mullarky
Bovine mastitis costs the dairy industry billions of dollars every year and presents a health challenge in dairy facilities. Immunosuppressive effects of the periparturient period increase the incidence of mastitis. During this time, cattle experience an elevation in circulating cortisol, which reduces polymorphonuclear cell function and ability to clear infection. OmniGen-AF (OMN; Phibro Animal Health, Teaneck, NJ) is an immunomodulatory feed additive that alters gene expression and is used to reduce rates of mastitis...
May 24, 2017: Journal of Dairy Science
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