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Nrf2 AND NQO1

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https://www.readbyqxmd.com/read/29163788/mind4-17-protects-retinal-pigment-epithelium-cells-and-retinal-ganglion-cells-from-uv
#1
Chaopeng Li, Kang Yan, Wenqi Wang, Qing Bai, Changming Dai, Xiaofeng Li, Darui Huang
Nrf2 activation would efficiently protect retinal cells from UV radiation (UVR). Recent studies have developed a Nrf2-targeting thiazole-containing compound MIND4-17, which activates Nrf2 through blocking its association with Keap1. In the current study, we demonstrated that pretreatment with MIND4-17 efficiently protected retinal pigment epithelium (RPE) cells (RPEs) and retinal ganglion cells (RGCs) from UVR. UVR-induced apoptosis in the retinal cells was also largely attenuated by MIND4-17 pretreatment. MIND4-17 presumably separated Nrf2 from Keap1, allowing its stabilization and accumulation in retinal cells, which then translocated to cell nuclei and promoted transcription of ARE-dependent anti-oxidant genes, including HO1, NQO1 and GCLM...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156292/dietary-luteolin-protects-against-hgcl2-induced-renal-injury-via-activation-of-nrf2-mediated-signaling-in-rat
#2
Xiao Tan, Biying Liu, Jingjing Lu, Siyu Li, Ruiqi Baiyun, Yueying Lv, Qian Lu, Zhigang Zhang
Luteolin (Lut) belongs to the flavonoid family with various beneficial bioactivities. Here, we investigated whether Lut attenuate mercuric chloride (HgCl2)-induced renal injury in rat. We found that oral gavage administration of Lut (80mg/kg) alleviated anemia and renal histology upon HgCl2 treatment (80mg/L). Lut also significantly reduced HgCl2-induced oxidative stress and inflammatory, presenting as the reduced malondialdehyde (MDA) formation, increased glutathione (GSH) level, and inhibited activation of nuclear factor kappa B (NF-κB)...
November 9, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29155359/4-methylthio-3-butenyl-isothiocyanate-mediates-nuclear-factor-erythroid-derived-2-like-2-activation-by-regulating-reactive-oxygen-species-production-in-human-esophageal-epithelial-cells
#3
Tadashi Hirata, Young-Man Cho, Isamu Suzuki, Takeshi Toyoda, Jun-Ichi Akagi, Yasushi Nakamura, Satoshi Numazawa, Kumiko Ogawa
4-Methylthio-3-butenyl isothiocyanate (MTBITC) extracted from daikon (Raphanus sativus), which shows antimutagenicity, may have applications as an effective chemopreventive agent in several cancers; however, few reports have described the associated mechanisms. We investigated whether MTBITC induced cytoprotective genes, including phase II enzymes, in Het-1A human esophageal epithelial cells. HMOX1, NQO1, and GCLC mRNA levels and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) protein levels were increased in Het-1A cells exposed to 10 μM MTBITC...
November 16, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29153953/inhibition-of-curcumin-on-influenza-a-virus-infection-and-influenzal-pneumonia-via-oxidative-stress-tlr2-4-p38-jnk-mapk-and-nf-%C3%AE%C2%BAb-pathways
#4
Jianping Dai, Liming Gu, Yun Su, Qianwen Wang, Ying Zhao, Xiaoxua Chen, Huixiong Deng, Weizhong Li, Gefei Wang, Kangsheng Li
Oxidative stress, Nrf2-HO-1 and TLR-MAPK/NF-κB signaling pathways have been proved to be involved in influenza A virus (IAV) replication and influenzal pneumonia. In the previous studies, we have performed several high-throughput drug screenings based on the TLR pathways. In the present study, through plaque inhibition test, luciferase reporter assay, TCID50, qRT-PCR, western blotting, ELISA and siRNA assays, we investigated the effect and mechanism of action of curcumin against IAV infection in vitro and in vivo...
November 15, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29149616/protective-effects-of-proanthocyanidins-against-cadmium-induced-testicular-injury-through-the-modification-of-nrf2-keap1-signal-path-in-rats
#5
Liu He, Peng Li, Li-Hui Yu, Lin Li, Yi Zhang, Yang Guo, Miao Long, Jian-Bin He, Shu-Hua Yang
The purpose of this study was to evaluate the potential chemoprotective effects of proanthocyanidins (PAs) against cadmium (Cd)-induced oxidative damage of testes via Nrf2-Keap1 signal pathway in rats. Briefly, by using biochemical histological analysis, as well as the real time PCR and western blot approach, oxidative damage in rat testicular tissue was observed after exposure to Cd. In addition, significant down-regulations of mRNA and protein levels of nuclear erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1), γ-glutamyl cysteine synthetase (γ-GCS), glutathione peroxidase (GSH-Px) and quinone oxidoreductase 1 (NQO1), as well as a significant up-regulation of Kelch sample related protein-1 (Keap1) levels in testicular tissue were observed after Cd exposure...
November 3, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29144506/soluble-p-selectin-promotes-retinal-ganglion-cell-survival-through-activation-of-nrf2-signaling-after-ischemia-injury
#6
Kishan Kapupara, Yao-Tseng Wen, Rong-Kung Tsai, Shun-Ping Huang
Retinal ischemic injuries play an important role in the pathogenesis of several eye disorders. Inflammation and oxidative stress are key players in ischemic injuries. Following retinal ischemia, vascular endothelial cells and leukocytes express several inflammatory adhesion receptors, such as selectins and cell adhesion molecules. P-selectin stimulates leukocyte recruitment to platelet aggregates and has an important role in vascular homeostasis and inflammatory leukocyte extravasation. Soluble P-selectin can be neuroprotective through competitive binding to the receptors of endogenous P-selectin molecules...
November 16, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29144408/antioxidant-effect-of-barley-sprout-extract-via-enhancement-of-nuclear-factor-erythroid-2-related-factor-2-activity-and-glutathione-synthesis
#7
Yun-Hee Lee, Sou Hyun Kim, Seunghyun Lee, Kyung-Mi Kim, Jae-Chul Jung, Tae Gen Son, Sung Hwan Ki, Woo-Duck Seo, Jae-Hwan Kwak, Jin Tae Hong, Young-Suk Jung
We previously showed that barley sprout extract (BSE) prevents chronic alcohol intake-induced liver injury in mice. BSE notably inhibited glutathione (GSH) depletion and increased inflammatory responses, revealing its mechanism of preventing alcohol-induced liver injury. In the present study we investigated whether the antioxidant effect of BSE involves enhancing nuclear factor-erythroid 2 related factor 2 (Nrf2) activity and GSH synthesis to inhibit alcohol-induced oxidative liver injury. Mice fed alcohol for four weeks exhibited significantly increased oxidative stress, evidenced by increased malondialdehyde (MDA) level and 4-hydroxynonenal (4-HNE) immunostaining in the liver, whereas treatment with BSE (100 mg/kg) prevented these effects...
November 16, 2017: Nutrients
https://www.readbyqxmd.com/read/29143802/the-inhibitory-effects-of-cobalt-protoporphyrin-ix-and-cannabinoid-2-receptor-agonists-in-type-2-diabetic-mice
#8
Christina McDonnell, Sergi Leánez, Olga Pol
The activation of the transcription factor Nrf2 inhibits neuropathy and modulates the activity of delta-opioid receptors (DOR) in type 2 diabetic mice but the impact of Nrf2/HO-1 pathway on the antinociceptive actions of cannabinoid 2 receptors (CB2R) has not been assessed. Using male mice BKS.Cg-m+/+Leprdb/J (db/db) we investigated if treatment with cobalt protoporphyrin IX (CoPP), an HO-1 inductor, inhibited mechanical allodynia, hyperglycemia and obesity associated to type 2 diabetes. The antinociceptive effects of JWH-015 and JWH-133 (CB2R agonists) administered with and without CoPP or sulforaphane (SFN), a Nrf2 transcription factor activator, have been also evaluated...
October 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29136249/natural-polyphenol-chlorogenic-acid-protects-against-acetaminophen-induced-hepatotoxicity-by-activating-erk-nrf2-antioxidative-pathway
#9
Mengjuan Wei, Zhiyong Zheng, Liang Shi, Yao Jin, Lili Ji
Hepatotoxicity due to acetaminophen (APAP) overdose is a leading cause of drug-induced acute liver failure in clinic. Chlorogenic acid (CGA), a dietary polyphenol, was reported to prevent APAP-induced liver injury in our previous studies. This study aims to investigate the protection provided by CGA against APAP-induced hepatotoxicity via focusing on nuclear factor erythroid 2-related factor 2 (Nrf2) and extracellular regulated protein kinases (ERK)1/2. CGA prevented APAP-induced oxidative liver injury and enhanced Nrf2 activation in mice and in hepatocytes in vitro...
November 10, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29135935/tucum-do-cerrado-bactris-setosa-mart-may-promote-anti-aging-effect-by-upregulating-sirt1-nrf2-pathway-and-attenuating-oxidative-stress-and-inflammation
#10
Marcela de Sá Barreto da Cunha, Sandra Fernandes Arruda
Aging may be related to oxidative damage accumulation and a low-grade inflammation, both responses are modulated by iron and phytochemicals. This study investigated the effect of tucum-do-cerrado (Bactris setosa Mart.) consumption on the expression of sirtuins (SIRT 1 and 3) and senescence marker protein-30 (SMP30), and on the redox and inflammatory responses, in adult rats supplemented or not with dietary iron. Male Wistar rats were treated for 12 weeks with: control diet (CT); iron enriched-diet (+Fe); control diet + 15% tucum-do-cerrado (Tuc); or iron enriched-diet + 15% tucum-do-cerrado (Tuc + Fe)...
November 14, 2017: Nutrients
https://www.readbyqxmd.com/read/29128856/activation-of-nrf2-pathway-and-inhibition-of-nlrp3-inflammasome-activation-contribute-to-the-protective-effect-of-chlorogenic-acid-on-acute-liver-injury
#11
Ameng Shi, Haitao Shi, Yan Wang, Xin Liu, Yan Cheng, Hong Li, Hongli Zhao, Shuangni Wang, Lei Dong
Chlorogenic acid (CGA), a kind of polyphenol found in coffee, fruits and vegetables, has potent anti-oxidant and anti-inflammatory properties. Our previous studies showed CGA could efficiently alleviate liver fibrosis in rats. However, whether CGA regulates nuclear factor erythroid-2-related factor 2 (Nrf2) anti-oxidant pathway and NLRP3 inflammasome activation and protects against carbon tetrachloride (CCl4)-induced acute liver injury are unknown. We found that CGA could increase Nrf2 activation and expression of Nrf2-related anti-oxidant genes, including HO-1, NQO1 and GCLC...
November 9, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29105806/the-orally-active-pterocarpanquinone-lqb-118-exhibits-cytotoxicity-in-prostate-cancer-cell-and-tumor-models-through-cellular-redox-stress
#12
Thiago Martino, Tarana A Kudrolli, Binod Kumar, Isis Salviano, André Mencalha, Marsen Garcia P Coelho, Graça Justo, Paulo R Ribeiro Costa, Kátia C Carvalho Sabino, Shawn E Lupold
BACKGROUND: The targeted induction of reactive oxygen species (ROS) is a developing mechanism for cancer therapy. LQB-118 is a pterocarpanquinone and ROS-inducing agent with proven antineoplastic activity. Here, LQB-118 efficacy and mechanism of activity, were examined in Prostate Cancer (PCa) cell and tumor models. METHODS: PC3, LNCaP, and LAPC4 PCa cells were applied. Dicoumarol treatment was used to inhibit quinone reductase activity. N-acetylcysteine (NAC) was applied as a ROS scavenger...
November 6, 2017: Prostate
https://www.readbyqxmd.com/read/29096944/an-in-vitro-inflammation-model-to-study-the-nrf2-and-nf-%C3%AE%C2%BAb-crosstalk-in-presence-of-ferulic-acid-as-modulator
#13
Nadia Lampiasi, Giovanna Montana
The aim of this study was to evaluate the crosstalk between Nrf2 and NF-κB signaling pathways and to explore the modulating activity actuated by ferulic acid. In the inflammation process, a key player is the nuclear factor-κB (NF-κB) transcription factor pathway. On the contrary, the activation of Nrf2 inhibits inflammation and impairs degenerative disease providing an interface between redox and anti-inflammatory responses. Recent studies have demonstrated that protein phosphorylation of IKK complex is a potential mechanism for the activation of both Nrf2 and NF-κB pathways...
October 27, 2017: Immunobiology
https://www.readbyqxmd.com/read/29078262/xiaochaihutang-attenuates-liver-fibrosis-by-activation-of-nrf2-pathway-in-rats
#14
Jin Li, Rui Hu, Shangfu Xu, Yuanyang Li, Ying Qin, Qin Wu, Zhi Xiao
Xiaochaihutang (XCHT) is a decoction of seven botanical extracts used for liver diseases traditionally in East Asia. However, few studies have investigated its anti-hepatic fibrosis effects and the mechanisms of action. Oxidative stress is one of the key factors responsible for occurrence and development of hepatic fibrosis and nuclear factor erythroid 2-related factor 2 (Nrf2) serves as a major regulator of the cellular defense system against oxidative stress. The aim of the present study was to investigate the effect of XCHT on liver fibrosis and focuse on the Nrf2 pathway in the protection of XCHT against CCl4-induced oxidative stress...
October 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29058292/danshen-modulates-nrf2-mediated-signaling-pathway-in-cisplatin-induced-renal-injury
#15
Si-Si Cao, Miao Yan, Zhen-Yan Hou, Ying Chen, Yun-Sheng Jiang, Xin-Rong Fan, Ping-Fei Fang, Bi-Kui Zhang
Danshen, an efficacious agent for cardiovascular diseases, has been found to play an essential role in kidney injury. In the present study, the effect of Danshen on cisplatin-induced renal dysfunction was investigated in a mouse model. Danshen was administered to mice at a dose of 3 g/kg 4 days before and 3 days after cisplatin treatment. A single intraperitoneal injection of 20 mg/kg cisplatin was used to induce nephrotoxicity. The mice were sacrificed 72 h after cisplatin intoxication. Biochemical parameters including serum creatinine and blood urea nitrogen were analyzed...
October 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/29053632/protective-effect-of-flavonoids-from-ziziphus-jujuba-cv-jinsixiaozao-against-acetaminophen-induced-liver-injury-by-inhibiting-oxidative-stress-and-inflammation-in-mice
#16
Weizhen Huang, Yongjie Wang, Xiaoyan Jiang, Yueyue Sun, Zhongxi Zhao, Siying Li
This study was aimed to investigate the chemical composition, antioxidant activities and hepatoprotective effect of flavonoids from Ziziphus jujuba cv. Jinsixiaozao (ZJF). The composition of ZJF was analyzed by high performance liquid chromatography (HPLC) and Liquid chromatography-mass spectrometry (LC-MS), and antioxidant properties were investigated by biological assays in vitro. The hepatoprotective activity of ZJF was evaluated in acetaminophen (APAP)-treated BALB/c mice. Results indicate that ZJF displayed significant antioxidant capacity...
October 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29050310/microrna-27b-inhibition-promotes-nrf2-are-pathway-activation-and-alleviates-intracerebral-hemorrhage-induced-brain-injury
#17
Wenzhe Xu, Feng Li, Zhiguo Liu, Zhenkuan Xu, Bin Sun, Jingwei Cao, Yuguang Liu
Oxidative stress and neuroinflammation are the key factors leading to secondary brain injury after intracerebral hemorrhage (ICH). We investigated the effects of miR-27b, an oxidative stress-responsive microRNA, on ICH-induced brain injury in rats. The ICH model was induced by intracerebral injection of collagenase. Following ICH, miR-27b expression in the striatum was reduced, whereas expression of Nrf2 mRNA and protein was increased. In PC12 cells, overexpression of miR-27b reduced expression of Nrf2, Hmox1, Sod1 and Nqo1, while miR-27b inhibition had the opposite effects...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029432/the-involvement-of-nrf2-in-the-protective-effects-of-epigallocatechin-3-gallate-egcg-on-naaso2-induced-hepatotoxicity
#18
Xiao-Dong Han, Yan-Yan Zhang, Ke-Lei Wang, Yong-Pan Huang, Zhong-Bao Yang, Zhi Liu
Arsenic exposure produces hepatotoxicity. The common mechanism determining its toxicity is the generation of oxidative stress. Oxidative stress induced by arsenic leads to the activation of nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. (-)-Epigallocatechin-3-gallate (EGCG) possesses a potent antioxidant capacity and exhibits extensive pharmacological activities. This study aims to evaluate effects of EGCG on arsenic-induced hepatotoxicity and activation of Nrf2 pathway. Plasma activities of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and lactate dehydrogenase were measured; Histological analyses were conducted to observe morphological changes; Biochemical indexes such as oxidative stress (Catalase (CAT), malonyldialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), reactive oxygen species (ROS)), Nrf2 signaling related genes (Nrf2, Nqo1, and Ho-1) were assessed...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029310/fragrance-allergens-linalool-and-limonene-allylic-hydroperoxides-in-skin-allergy-mechanisms-of-action-focusing-on-transcription-factor-nrf2
#19
Chloé Raffalli, Elodie Clouet, Salen Kuresepi, Marie-Hélène Damiens, Jean-Pierre Lepoittevin, Marc Pallardy, Pierre-Jacques Ferret, Elena Giménez-Arnau, Saadia Kerdine-Römer
Allergic contact dermatitis (ACD) is regarded as the most frequent expression of immunotoxicity in humans. Many odorant terpenes commonly used in fragrance compositions are considered as weak skin sensitizers, whereas some of their autoxidation products, allylic hydroperoxides, are classified as strong sensitizers according to the Local Lymph Node Assay (LLNA). However, the mechanism of their effects on the immune system remains unclear. Since dendritic cells play a key role in ACD, we studied their activation by the frequently used linalool (LINA) and limonene (LIMO), and their respective sensitizing allylic hydroperoxides (LINA-OOH, LIMO-OOH)...
September 29, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29022012/vanadate-oxidative-and-apoptotic-effects-are-mediated-by-the-mapk-nrf2-pathway-in-layer-oviduct-magnum-epithelial-cells
#20
Jianping Wang, Xuanyang Huang, Keying Zhang, Xiangbing Mao, Xuemei Ding, Qiufeng Zeng, Shiping Bai, Yue Xuan, Huanwei Peng
Vanadium is a metal of high physiological, environmental and industrial importance. However, vanadium-induced oxidative stress can reduce the egg quality of poultry, and be potentially harmful to humans, and the underlying mechanism is not clear. In this study, we investigated the underlying relationship between the oxidant-sensitive mitogen-activated protein kinase (MAPK) signaling pathway and vanadium-induced oxidative stress in oviduct magnum epithelial (OME) cells. Cultured OME cells were treated with 100 μmol L(-1) vanadium and/or MAPK inhibitors [P38 MAPK inhibitor, SB203580; extracellular regulated protein kinase 1 and 2 (ERK1/2) inhibitor, U0126; c-JUN N-terminal kinases (JNK) inhibitor, SP600125]...
November 15, 2017: Metallomics: Integrated Biometal Science
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