keyword
MENU ▼
Read by QxMD icon Read
search

Kidney cancer pathology

keyword
https://www.readbyqxmd.com/read/29777523/application-of-cu-64-nodaga-psma-pet-in-prostate-cancer
#1
Sabina Sevcenco, Hans Christoph Klingler, Klaus Eredics, Alexander Friedl, Jenifer Schneeweiss, Peter Knoll, Thomas Kunit, Lukas Lusuardi, Siroos Mirzaei
INTRODUCTION: The high diagnostic potential of 64 Cu-PSMA PET-CT imaging was clinically investigated in prostate cancer patients with recurrent disease and in the primary staging of selected patients with advanced local disease. The aim of our study is to assess the uptake behavior in the clinical setting of 64Copper Prostate-Specific Membrane Antigen (64 Cu PSMA) Positron Emission Tomography/Computed Tomography (PET/CT) in prostate cancer. METHODS: A retrospective study was performed in 23 patients with intermediate, high risk and progressive disease at primary staging of prostate cancer...
May 17, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29767974/in-vitro-and-in-vivo-demonstration-of-human-ovarian-cancer-necrosis-through-a-water-soluble-and-near-infrared-absorbing-chlorin
#2
Betsy Marydasan, Bollapalli Madhuri, Shirisha Cherukommu, Jedy Jose, Mambattakkara Viji, Suneesh C Karunakaran, Tavarekere K Chandrashekar, Kunchala Sridhar Rao, Ch Mohan Rao, Danaboyina Ramaiah
With an objective to develop efficient sensitizers for therapeutical applications, we synthesized a water soluble, 5,10,15,20-tetrakis(3,4-dihydroxyphenyl)chlorin (TDC), and investigated its in vitro and in vivo biological efficacy and compared with the commercially available sensitizers. TDC showed high water solubility (6-fold), when compared to Foscan and exhibited excellent triplet excited state () and singlet oxygen () yields. In vitro photobiological investigations in human ovarian cancer cell lines SKOV-3 showed high photocytotoxicity, negligible dark toxicity, rapid cellular uptake and specific localization of TDC in neoplastic cells as assessed by flow cytometric cell-cycle and propidium iodide staining analysis...
May 16, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29739453/spontaneous-renal-hemorrhage-secondary-to-choriocarcinoma-in-a-man-with-congenital-hypospadias-and-cryptorchidism-a-case-report-and-literature-review
#3
Yi Li, Gang Chen, Han Chen, Shuang Wen, Chao-Yu Xiong, Zi-Yi Yang, Yun-Xiao Zhu, Nathan Jeffreys
BACKGROUND: Choriocarcinoma is a rare malignant germ-cell tumour, most commonly found in adult women. It infrequently presents as spontaneous renal haemorrhage (SRH). Genital malformation and SRH secondary to choriocarcinoma has previously been only reported in females. We present what we believe to be the first case of a male patient with genital malformation (hypospadias and cryptorchidism) and SRH at presentation of choriocarcinoma. CASE PRESENTATION: A 25-year-old man presented to the department with intense pain in the right flank region and lower back...
May 8, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29731099/oncologic-outcomes-of-post-kidney-transplantation-superficial-urothelial-carcinoma
#4
G-L Huang, H-L Luo, Y-T Chen, Y-T Cheng
PURPOSE: To analyze the oncologic effect of post-kidney transplantation (KT) immunosuppressive status for end-stage renal disease (ESRD) patients with superficial urothelial carcinoma. METHODS: From 2010 to 2015, there were 106 ESRD patients with superficial urinary bladder urothelial carcinoma (UB-UC) and 68 ESRD patients with superficial upper urinary tract urothelial carcinoma (UT-UC) in a single institution. Oncologic outcomes including bladder cancer recurrences and systemic disease recurrences within 5 years were compared between patients with and without KT...
May 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29730837/contemporary-assessment-of-the-correlation-between-bosniak-classification-and-histological-characteristics-of-surgically-removed-atypical-renal-cysts-uroccr-12-study
#5
François-Xavier Nouhaud, Jean-Christophe Bernhard, Pierre Bigot, Zine-Eddine Khene, François Audenet, Herve Lang, Sebastien Bergerat, Guillaume Fraisse, Nicolas Grenier, François Cornelis, Cosmina Nedelcu, Sofiane Béjar, Gaëlle Fromont-Hankard, Yves Allory, Véronique Lindner, Virginie Verkarre, Laurent Daniel, Mokrane Yacoub, Jean-Michel Correas, Arnaud Méjean, Nathalie Rioux-Leclercq, Karim Bensalah
PURPOSE: To evaluate and compare pathological characteristics of renal cysts Bosniak IIF, III and IV in light of recent histological classification. PATIENTS AND METHODS: The French research network for kidney cancer UroCCR conducted a multicentre study on patients treated surgically for a renal cyst between 2007 and 2016. Independent radiological and centralized pathological reviews were performed for every patient. Pathological characteristics were compared to the Bosniak classification...
May 5, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29720944/identification-of-biomarkers-associated-with-pathological-stage-and-prognosis-of-clear-cell-renal-cell-carcinoma-by-co-expression-network-analysis
#6
Liang Chen, Lushun Yuan, Kaiyu Qian, Guofeng Qian, Yuan Zhu, Chin-Lee Wu, Han C Dan, Yu Xiao, Xinghuan Wang
Clear cell renal cell carcinoma (ccRCC) is the most common subtype among renal cancer whose prognostic is affected by the tumor progression associated with complex gene interactions. However, there is currently no available molecular markers associated with ccRCC progression and used or clinical application. In our study, microarray data of 101 ccRCC samples and 95 normal kidney samples were analyzed and 2,425 differentially expressed genes (DEGs) were screened. Weighted gene co-expression network analysis (WGCNA) was then conducted and 11 co-expressed gene modules were identified...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29693458/segmental-ureterectomy-is-acceptable-for-high-risk-ureteral-carcinoma-comparing-to-radical-nephroureterectomy
#7
Zixiong Huang, Xiaowei Zhang, Xiaopeng Zhang, Qing Li, Shijun Liu, Luping Yu, Tao Xu
PURPOSE: To determine if segmental ureterectomy (SU) could be chosen for wider oncological indications than low-risk ureteral carcinoma, given the difficulties in accurate preoperative risk stratification determination and kidney-sparing needs for successive therapy. METHODS: Data from ureteral carcinoma patients who underwent open SU or laparoscopic radical nephroureterectomy (RNU) between 2011 and 2016 were retrospectively reviewed. Kaplan-Meier survival analysis and Cox regression model with patients' baseline characteristics (age, bladder cancer history, hydronephrosis), procedure type, and tumor characteristics (site, size, pathological features) as covariates were used to evaluate oncological outcomes...
April 25, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29689304/proteomics-of-liquid-biopsies-depicting-rcc-infiltration-into-the-renal-vein-by-ms-analysis-of-urine-and-plasma
#8
Clizia Chinello, Martina Stella, Isabella Piga, Andrew James Smith, Giorgio Bovo, Marta Varallo, Mariia Ivanova, Vanna Denti, Marco Grasso, Angelica Grasso, Marina Del Puppo, Apostolos Zaravinos, Fulvio Magni
Liquid biopsies, as blood and urine, could offer an invaluable, easily accessible source of biomarkers, and evidences for elucidating the pathological processes. Only few studies integrated the proteomes driven by more than one biofluid. Furthermore, it is not clear which biofluid better mirrors the alterations triggered by disease. Venous infiltrating RCC(Renal Cell Carcinoma) could represent an advantageous model for exploring this aspect. Herein, we investigate how blood and urine "proteomically" reflect the changes occurring during RCC infiltration into renal vein(RV) by label-free nLC-ESI-MS/MS...
April 21, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29650272/treatment-of-spinal-metastases-in-renal-cell-carcinoma-a-critical-review
#9
REVIEW
Diego Teyssonneau, Marine Gross-Goupil, Charlotte Domblides, Thibaud Haaser, Vincent Pointillart, Amaury Daste, Olivier Hauger, Alain Ravaud
Kidney cancer is the 9th most common cancer in men and the 14th most common in women worldwide. Renal cell carcinoma (RCC) constitutes 90% of all malignancies of the kidney. RCC, is known to be highly vascular and relatively radioresistant. Bone metastases are one of the most common metastatic sites and occur in around 30% of RCCs. They significantly impact the quality of life of patients causing pain and pathological fractures. Spinal metastases represent a particular case with regard to symptoms and treatment...
May 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29620271/mir%C3%A2-152-regulates-tgf%C3%A2-%C3%AE-1%C3%A2-induced-epithelial%C3%A2-mesenchymal-transition-by-targeting-hpip-in-tubular-epithelial-cells
#10
Ya-Xian Ning, Xiao-Yuan Wang, Jian-Qin Wang, Rong Zeng, Gou-Qin Wang
Renal fibrosis is a common pathological feature of chronic kidney diseases, and their development and progression are influenced by epigenetic modifications including aberrant microRNA (miRNA or miR) expression. miRNAs have been demonstrated to modulate the aggressiveness of various cancers and have emerged as possible therapeutic agents for the management of renal fibrosis. Transforming growth factor β1 (TGF‑β1)‑induced epithelial‑mesenchymal transition (EMT) of tubular epithelial cells serves a role in the initiation and progression of renal fibrosis...
April 3, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29617076/completely-endophytic-renal-tumor-a-laparoscopic-approach
#11
Victor Espinheira Santos, Rafael Ribeiro Meduna, Wilson Bachega, Gustavo Cardoso Guimarães
Kidney cancer is the third most common urologic malignancy and a 2% annual increase in the incidence has occurred over the past two decades, largely because of the increased utilization of imaging. The majority of these tumors are small, so the indications for nephron-sparing surgery and for minimally invasive surgery are continually expanding. Complex kidney lesions, such as those completely endophytic, are still a challenge even for experienced surgeons. Our objective is to demonstrate the operative technique for laparoscopic partial nephrectomy with the aid of intra-operative ultrasound in a man with a totally endophytic renal lesion...
March 15, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29615539/induction-regulation-and-roles-of-neural-adhesion-molecule-l1cam-in-cellular-senescence
#12
Blanka Mrazkova, Rastislav Dzijak, Terezie Imrichova, Lenka Kyjacova, Peter Barath, Petr Dzubak, Dusan Holub, Marian Hajduch, Zuzana Nahacka, Ladislav Andera, Petr Holicek, Pavla Vasicova, Olena Sapega, Jiri Bartek, Zdenek Hodny
Aging involves tissue accumulation of senescent cells (SC) whose elimination through senolytic approaches may evoke organismal rejuvenation. SC also contribute to aging-associated pathologies including cancer, hence it is imperative to better identify and target SC. Here, we aimed to identify new cell-surface proteins differentially expressed on human SC. Besides previously reported proteins enriched on SC, we identified 78 proteins enriched and 73 proteins underrepresented in replicatively senescent BJ fibroblasts, including L1CAM, whose expression is normally restricted to the neural system and kidneys...
March 28, 2018: Aging
https://www.readbyqxmd.com/read/29587322/-the-role-of-biomarkers-in-the-diagnosis-prognosis-and-therapy-of-patients-with-immuno-oncological-treatments-of-genito-urinary-carcinomas
#13
Eva Compérat, Caroline Eymerit, Julien Moroch, Justin Varinot
In recent years, fundamental research has yielded new insights into tumour biology, and new treatments have been developed. This review highlights the role of the pathologist and how he can support clinicians to find the right treatment for each patient. We explain the problems of the molecular subgroups of bladder cancer, the role of neo-adjuvant chemotherapy in the context of these findings, and show the important role of checkpoint inhibitors. Furthermore we focus on kidney cancer, with the clear cell carcinoma as the most frequent tumour type...
April 2018: Aktuelle Urologie
https://www.readbyqxmd.com/read/29579850/reasons-for-noninclusion-on-the-kidney-transplant-waiting-list-analysis-in-a-set-of-hemodialysis-centers
#14
N G Toapanta-Gaibor, M Suñer-Poblet, M Cintra-Cabrera, M Á Pérez-Valdivia, A Suárez-Benjumea, F M Gonzalez-Roncero, G Bernal-Blanco, J L Rocha-Castilla, M Á Gentil-Govantes
INTRODUCTION: End-stage renal disease patients' access to the renal transplant (RT) waiting list (WL) depends on general criteria and their specific application in the different treatment units. METHODS: Study in nonhospital hemodialysis centers (n = 9), dependent on an adult RT center. Cases included 228 patients considered to have nonactive status on the WL due to incomplete immunologic data (no blood group or HLA typing) or temporary contraindication from an incomplete pretransplant study (nonimmunologic) or comorbidity...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29574162/surgical-treatment-in-bone-metastases-in-the-appendicular-skeleton
#15
M A Clara-Altamirano, D Y Garcia-Ortega, H Martinez-Said, C H S Caro-Sánchez, A Herrera-Gomez, M Cuellar-Hubbe
INTRODUCTION: Metastatic bone disease is the most common neoplastic process that affects the skeletal system. Eighty percent of bone metastases come from carcinomas of the breast, lung, kidney, thyroid and prostate. The Katagiri scale enables an estimation of the survival of patients based on the presence or absence of visceral metastases, multiple bone metastases and functional status according to the ECOG scale. MATERIAL AND METHODS: A retrospective, descriptive and observational study conducted between March 1, 2013 and June 30, 2015...
March 21, 2018: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/29563747/role-of-rplnd-and-metastasectomy-in-the-management-of-oligometastatic-renal-cell-carcinoma
#16
H Nagaraja, N Srivatsa, S Hemalatha, S Shweta, S K Raghunath
Although lymphadenectomy is currently accepted as most accurate and reliable staging procedure for lymph node metastases, its therapeutic benefit in renal cell carcinoma (RCC) still remains controversial. Although the new, targeted therapy paradigms have changed the treatment of patients with advanced RCC and offer prolonged survival, cure is extremely uncommon in the absence of surgical resections. In this paper, the current role of metastasectomy is reviewed. Review the available literature concerning the role of retroperitoneal lymph node dissection and metastasectomy in outcome of oligometastatic RCC...
March 2018: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29555977/epigenetic-restriction-of-hippo-signaling-by-morc2-underlies-stemness-of-hepatocellular-carcinoma-cells
#17
Tao Wang, Zhong-Yi Qin, Liang-Zhi Wen, Yan Guo, Qin Liu, Zeng-Jie Lei, Wei Pan, Kai-Jun Liu, Xing-Wei Wang, Shu-Jie Lai, Wen-Jing Sun, Yan-Ling Wei, Lei Liu, Ling Guo, Yu-Qin Chen, Jun Wang, Hua-Liang Xiao, Xiu-Wu Bian, Dong-Feng Chen, Bin Wang
The evolutionarily conserved Hippo signaling pathway is a key regulator of stem cell self-renewal, differentiation, and organ size. While alterations in Hippo signaling are causally linked to uncontrolled cell growth and a broad range of malignancies, genetic mutations in the Hippo pathway are uncommon and it is unclear how the tumor suppressor function of the Hippo pathway is disrupted in human cancers. Here, we report a novel epigenetic mechanism of Hippo inactivation in the context of hepatocellular carcinoma (HCC)...
March 19, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29555576/aberrant-high-expression-level-of-morc2-is-a-common-character-in-multiple-cancers
#18
Ding Qian-Shan, Zhang Li, Wang Bi-Cheng, Zeng Zhi, Zou Xian-Qiong, Cao Peng-Bo, M S Zhou Guang-Ming, Tang Meng, Wu Lu, B S Wu Lian-Lian, Yu Hong-Gang, Guo Yong, Zhou Fu-Xiang
Microrchidia 2 (MORC2) plays important roles in DNA damage repair and lipogenesis, but the clinical and functional role of MORC2 in cancer remains largely unexplored. In this study, we showed that MORC2 was widely expressed in human tissues while significantly up-regulated in most cancer types employing immunohistochemical staining and analysis of mRNA expression profile of more than 2000 human tissue samples from 15 different organs (lung, prostate, liver, breast, brain, stomach, colon/rectum, pancreas, ovary, endometrium, skin, nasopharynx, kidney, oesophagus and bladder)...
March 16, 2018: Human Pathology
https://www.readbyqxmd.com/read/29545133/endoglin-based-in-vivo-near-infrared-fluorescence-imaging-of-tumor-models-in-mice-using-activatable-liposomes
#19
Felista L Tansi, Ronny Rüger, Ansgar M Kollmeier, Markus Rabenhold, Frank Steiniger, Roland E Kontermann, Ulf K Teichgraeber, Alfred Fahr, Ingrid Hilger
BACKGROUND: Endoglin (CD105) is overexpressed on tumor cells and tumor vasculatures, making it a potential target for diagnostic imaging and therapy of different neoplasms. Therefore, studies on nanocarrier systems designed for endoglin-directed diagnostic and drug delivery purposes would expose the feasibility of targeting endoglin with therapeutics. METHODS: Liposomes carrying high concentrations of a near-infrared fluorescent dye in the aqueous interior were prepared by the lipid film hydration and extrusion procedure, then conjugated to single chain antibody fragments either selective for murine endoglin (termed mEnd-IL) or directed towards human endoglin (termed hEnd-IL)...
March 13, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29540482/pharmacologically-targeting-the-myristoylation-of-the-scaffold-protein-frs2%C3%AE-inhibits-fgf-fgfr-mediated-oncogenic-signaling-and-tumor-progression
#20
Qianjin Li, Omar Awad Alsaidan, Yongjie Ma, Sungjin Kim, Junchen Liu, Thomas Albers, Kebin Liu, Zanna Beharry, Shaying Zhao, Fen Wang, Iryna Lebedyeva, Houjian Cai
Fibroblast growth factor (FGF)/FGF receptor (FGFR) signaling facilitates tumor initiation and progression. Although currently approved inhibitors of FGFR kinase have shown therapeutic benefit in clinical trials, overexpression or mutations of FGFRs eventually confer drug resistance and thereby abrogate the desired activity of kinase inhibitors in many cancer types. In this study, we report that loss of myristoylation of fibroblast growth factor receptor substrate 2 (FRS2α), a scaffold protein essential for FGFR signaling, inhibits FGF/FGFR-mediated oncogenic signaling and FGF10-induced tumorigenesis...
April 27, 2018: Journal of Biological Chemistry
keyword
keyword
95539
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"