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Kidney cancer pathology

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https://www.readbyqxmd.com/read/27932164/retzius-space-preservation-technique-for-robotic-assisted-laparoscopic-radical-prostatectomy-in-a-kidney-transplant-patient-first-case-in-thailand-and-our-first-experience
#1
P Jenjitranant, P Sangkum, P Sirisreetreerux, W Viseshsindh, S Patcharatrakul, W Kongcharoensombat
OBJECTIVE: The aim of this work was to report our experience in robotic-assisted laparoscopic radical prostatectomy for the treatment of localized prostate cancer in a kidney transplant recipient. METHODS: A 73-year-old man with chronic renal failure underwent living-donor kidney transplantation (KT) in 1993. His baseline creatinine after KT was ∼1.2 mg/dL. He developed lower urinary tract symptoms in 1999. He was diagnosed with benign prostatic hyperplasia and treated accordingly...
November 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27919129/-a-case-of-recurrent-renal-cancer-in-the-autografted-kidney-treated-with-percutaneous-cryoablation
#2
Eisuke Tomiyama, Shinichiro Fukuhara, Takeshi Ujike, Akira Nagahara, Motohide Uemura, Hiroshi Kiuchi, Ryoichi Imamura, Yasushi Miyagawa, Mikio Nin, Norio Nonomura
We report a case of recurrent renal cancer in the autografted kidney, treated with percutaneous cryoablation. A 59-year-old man who had bilateral renal tumors underwent radical left nephrectomy, ex vivo right partial nephrectomy and auto-transplantation at the right ileal fossa in our hospital 11 years ago. Histopathological examination showed clear cell renal cell carcinoma in bilateral kidneys (pT1bN0M0). He had been followed at another hospital without tumor recurrence for 11 years. In 2014, an enhanced CT scan revealed a renal tumor with a diameter of two centimeters in the autografted kidney, which was thought to be a recurrence of the initial renal cancer...
October 2016: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/27909618/clinico-pathological-outcomes-of-post-primary-and-salvage-chemotherapy-retroperitoneal-lymph-node-dissection-for-mixed-germ-cell-tumors-king-hussein-cancer-center-experience
#3
Kholoud Alqasem, Ibrahim Abukhiran, Judy Jasser, Tamer Bisharat, Riyad T Ellati, Jakub Khzouz, Ibrahim Al-Saidi, Ali Al-Daghamin
OBJECTIVE: We sought to characterize clinical and pathologic outcomes of advanced mixed germ cell tumors after retroperitoneal lymph node dissection for post-chemotherapy residual masses. MATERIAL AND METHODS: Between January 2006 and November 2015, 56 patients underwent retroperitoneal lymph node dissection (RPLND) for residual masses of greater than 1 cm after receiving either primary chemotherapy or salvage chemotherapy. Retrospective review of the patients' characteristics, clinical, pathological, and treatment outcomes were performed after institutional review board (IRB) and ethics committee approval...
December 2016: Turkish Journal of Urology
https://www.readbyqxmd.com/read/27899233/clear-cell-type-a-and-b-molecular-subtypes-in-metastatic-clear-cell-renal-cell-carcinoma-tumor-heterogeneity-and-aggressiveness
#4
Daniel J Serie, Richard W Joseph, John C Cheville, Thai H Ho, Mansi Parasramka, Tracy Hilton, R Houston Thompson, Bradley C Leibovich, Alexander S Parker, Jeanette E Eckel-Passow
BACKGROUND: Intratumor molecular heterogeneity has been reported for primary clear cell renal cell carcinoma (ccRCC) tumors; however, heterogeneity in metastatic ccRCC tumors has not been explored. OBJECTIVE: To evaluate intra- and intertumor molecular heterogeneity in resected metastatic ccRCC tumors. DESIGN, SETTING, AND PARTICIPANTS: We identified 111 patients who had tissue available from their primary tumor and at least one metastasis...
November 26, 2016: European Urology
https://www.readbyqxmd.com/read/27883184/epigenetics-in-reactive-and-reparative-cardiac-fibrogenesis-the-promise-of-epigenetic-therapy
#5
REVIEW
Asish K Ghosh, Rahul Rai, Panagiotis Flevaris, Douglas E Vaughan
Epigenetic changes play a pivotal role in the development of a wide spectrum of human diseases including cardiovascular diseases, cancer, diabetes, and intellectual disabilities. Cardiac fibrogenesis is a common pathophysiological process seen during chronic and stress-induced accelerated cardiac aging. While adequate production of extracellular matrix (ECM) proteins is necessary for post-injury wound healing, excessive synthesis and accumulation of extracellular matrix protein in the stressed or injured hearts causes decreased or loss of lusitropy that leads to cardiac failure...
November 24, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27863399/different-non-synonymous-polymorphisms-modulate-the-interaction-of-the-wrn-protein-to-its-protein-partners-and-its-enzymatic-activities
#6
Jean-Philippe Gagné, Sophie Lachapelle, Chantal Garand, Serges P Tsofack, Yan Coulombe, Marie-Christine Caron, Guy G Poirier, Jean-Yves Masson, Michel Lebel
Werner syndrome (WS) is characterized by the premature onset of several age-associated pathologies including cancer. The protein defective in WS patients (WRN) is a helicase/exonuclease involved in DNA replication and repair. Here, we present the results of a large-scale proteome analysis that has been undertaken to determine protein partners of different polymorphic WRN proteins found with relatively high prevalence in the human population. We expressed different fluorescently tagged-WRN (eYFP-WRN) variants in human 293 embryonic kidney cells (HEK293) and used a combination of affinity-purification and mass spectrometry to identify different compositions of WRN-associated protein complexes...
November 14, 2016: Oncotarget
https://www.readbyqxmd.com/read/27859269/homocysteine-as-a-pathological-biomarker-for-bone-disease
#7
REVIEW
Jyotirmaya Behera, Jyoti Bala, Mohammed Nuru, Suresh C Tyagi, Neetu Tyagi
In the last few decades, perturbation in methyl-group and homocysteine (Hcy) balance have emerged as independent risk factors in a number of pathological conditions including neurodegenerative disease, cardiovascular dysfunction, cancer development, autoimmune disease and kidney disease. Recent studies report Hcy to be a newly recognized risk factor for osteoporosis. Elevated Hcy levels are known to modulate osteoclastgenesis by causing detrimental effects on bone via oxidative stress induced metalloproteinase-mediated extracellular matrix degradation and decrease in bone blood flow...
November 18, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27846002/renal-metastasis-from-primary-thyroid-cancer-on-131i-and-mri-imaging
#8
Darshan R Patel, Bhishak H Kamat, Michael D Farwell
A 66-year-old woman with a history of papillary thyroid cancer status after total thyroidectomy underwent I radioiodine ablation therapy 3 months after surgery. Posttherapy whole body planar imaging revealed focal intense I uptake in the posterior right abdomen. SPECT/CT of this region localized the uptake to the medial lower pole of the right kidney. Further evaluation with MRI demonstrated a correlative suspicious right renal mass. The patient underwent right partial nephrectomy with pathology demonstrating that the renal mass was of thyroidal origin (papillary subtype)...
January 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27822117/the-danish-testicular-cancer-database
#9
REVIEW
Gedske Daugaard, Maria Gry Gundgaard Kier, Mikkel Bandak, Mette Saksø Mortensen, Heidi Larsson, Mette Søgaard, Birgitte Groenkaer Toft, Birte Engvad, Mads Agerbæk, Niels Vilstrup Holm, Jakob Lauritsen
AIM: The nationwide Danish Testicular Cancer database consists of a retrospective research database (DaTeCa database) and a prospective clinical database (Danish Multidisciplinary Cancer Group [DMCG] DaTeCa database). The aim is to improve the quality of care for patients with testicular cancer (TC) in Denmark, that is, by identifying risk factors for relapse, toxicity related to treatment, and focusing on late effects. STUDY POPULATION: All Danish male patients with a histologically verified germ cell cancer diagnosis in the Danish Pathology Registry are included in the DaTeCa databases...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27815768/diabetes-and-kidney-cancer-outcomes-a-propensity-score-analysis
#10
Madhur Nayan, Antonio Finelli, Michael A S Jewett, David N Juurlink, Peter C Austin, Girish S Kulkarni, Robert J Hamilton
There is conflicting evidence whether diabetes is associated with survival outcomes in patients undergoing a nephrectomy for renal cell carcinoma. We performed a retrospective review of 1034 patients undergoing nephrectomy for unilateral, M0, renal cell carcinoma between 2000 and 2016 at a tertiary academic center. Inverse probability of treatment weights were derived from a propensity score model based on various clinical, surgical, and pathological characteristics. We used Cox proportional hazard models to evaluate the association between diabetes and disease-free survival, cancer-specific survival, and overall survival in the sample weighted by the inverse probability of treatment weights...
November 4, 2016: Endocrine
https://www.readbyqxmd.com/read/27802451/microrna-193b-3p-as-a-predictive-biomarker-of-chronic-kidney-disease-in-patients-undergoing-radical-nephrectomy-for-renal-cell-carcinoma
#11
Francesco Trevisani, Michele Ghidini, Alessandro Larcher, Andrea Lampis, Hazel Lote, Paolo Manunta, Maria Teresa Sciarrone Alibrandi, Laura Zagato, Lorena Citterio, Giacomo Dell'Antonio, Cristina Carenzi, Giovambattista Capasso, Massimo Rugge, Paolo Rigotti, Roberto Bertini, Luciano Cascione, Alberto Briganti, Andrea Salonia, Fabio Benigni, Chiara Braconi, Matteo Fassan, Jens Claus Hahne, Francesco Montorsi, Nicola Valeri
BACKGROUND: A significant proportion of patients undergoing radical nephrectomy (RN) for clear-cell renal cell carcinoma (RCC) develop chronic kidney disease (CKD) within a few years following surgery. Chronic kidney disease has important health, social and economic impact and no predictive biomarkers are currently available. MicroRNAs (miRs) are small non-coding RNAs implicated in several pathological processes. METHODS: Primary objective of our study was to define miRs whose deregulation is predictive of CKD in patients treated with RN...
November 22, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27801735/fading-with-time-of-pd-l1-immunoreactivity-in-non-small-cells-lung-cancer-tissues-a-methodological-study
#12
Francesca Giunchi, Alessio Degiovanni, Niccolò Daddi, Rocco Trisolini, Andrea Dell'Amore, Claudio Agostinelli, Andrea Ardizzoni, Michelangelo Fiorentino
Blockade of inhibitory immune checkpoints is currently arising as a potential immunologic option for tumor therapy. Inhibition of programmed cell death protein 1 and/or its specific ligand programmed death-ligand 1 (PD-L1) was effective in clinical trials in advanced melanoma, non-small cell lung cancer (NSCLC) bladder and kidney cancer. The predictive role of the immunohistochemical (IHC) expression of PD-L1 is highly debated. Different reagents, clones, cutoffs of cell expression and subjective interpretation of PD-L1 immunoreactivity in epithelial cells and lymphocytes are the main issue...
October 31, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/27775595/the-molecular-and-cellular-effect-of-homocysteine-metabolism-imbalance-on-human-health
#13
Henrieta Škovierová, Eva Vidomanová, Silvia Mahmood, Janka Sopková, Anna Drgová, Tatiana Červeňová, Erika Halašová, Ján Lehotský
Homocysteine (Hcy) is a sulfur-containing non-proteinogenic amino acid derived in methionine metabolism. The increased level of Hcy in plasma, hyperhomocysteinemia, is considered to be an independent risk factor for cardio and cerebrovascular diseases. However, it is still not clear if Hcy is a marker or a causative agent of diseases. More and more research data suggest that Hcy is an important indicator for overall health status. This review represents the current understanding of molecular mechanism of Hcy metabolism and its link to hyperhomocysteinemia-related pathologies in humans...
October 20, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27767378/rna-binding-protein-qki-5-inhibits-the-proliferation-of-clear-cell-renal-cell-carcinoma-via-post-transcriptional-stabilization-of-rasa1-mrna
#14
Rui-Li Zhang, Jun-Ping Yang, Li-Xia Peng, Li-Sheng Zheng, Ping Xie, Meng-Yao Wang, Yun Cao, Zhi-Ling Zhang, Fang-Jian Zhou, Chao-Nan Qian, Yong-Xing Bao
Clear cell renal cell carcinoma (ccRCC) is a common pathological subtype of renal cancer. Although the recent application of molecular-targeted agents has modestly improved the prognosis of ccRCC patients, their outcome is still poor. It is therefore important to characterize the molecular and biological mechanisms responsible for the development of ccRCC. Approximately 25% ccRCC patients involves the loss of RNA-binding protein QKI at 6q26, but the role of QKI in ccRCC is unknown. Here, we found that QKI-5 was frequently downregulated in ccRCC patients and its down-regulation was significantly associated with clinical features including T status, M status, and differentiation grade, and poorer patient prognosis...
October 21, 2016: Cell Cycle
https://www.readbyqxmd.com/read/27766038/indoxyl-sulfate-enhance-the-hypermethylation-of-klotho-and-promote-the-process-of-vascular-calcification-in-chronic-kidney-disease
#15
Jing Chen, Xiaoyan Zhang, Han Zhang, Tongqiang Liu, Hui Zhang, Jie Teng, Jun Ji, Xiaoqiang Ding
Chronic kidney disease (CKD) is a state of Klotho deficiency. The Klotho expression may be suppressed due to DNA hypermethylation in cancer cells so we have investigated the effects and possible mechanisms by which Klotho expression is regulated in human aortic smooth muscle cells (HASMCs). The vascular Klotho hypermethylation in radial arteries of patients with end-stage renal disease was described. Cultured HASMCs and 5/6-nephrectomized Sprague Dawley (SD) rats treated with indoxyl sulfate (IS) were used as in vitro and in vivo models, respectively...
2016: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/27764139/prevalence-of-glomerulopathies-in-canine-mammary-carcinoma
#16
Leandro Z Crivellenti, Gyl E B Silva, Sofia Borin-Crivellenti, Rachel Cianciolo, Christopher A Adin, Márcio Dantas, Denner S Dos Anjos, Mirela Tinucci-Costa, Aureo E Santana
The incidence and prevalence of paraneoplastic glomerulopathy, especially associated with carcinoma, are a matter of debate and the causal link between cancer and glomerular diseases remains unclear. The aim of this study was to evaluate renal biopsies of selected bitches with spontaneous mammary gland carcinoma. We hypothesized that dogs with mammary carcinomas would show histologic evidence of glomerular pathology. A prospective study was performed in dogs with naturally occurring mammary carcinoma that were undergoing tumor resection and ovariohysterectomy...
2016: PloS One
https://www.readbyqxmd.com/read/27757935/impact-of-salt-intake-on-the-pathogenesis-and-treatment-of-hypertension
#17
Petra Rust, Cem Ekmekcioglu
Excessive dietary salt (sodium chloride) intake is associated with an increased risk for hypertension, which in turn is especially a major risk factor for stroke and other cardiovascular pathologies, but also kidney diseases. Besides, high salt intake or preference for salty food is discussed to be positive associated with stomach cancer, and according to recent studies probably also obesity risk. On the other hand a reduction of dietary salt intake leads to a considerable reduction in blood pressure, especially in hypertensive patients but to a lesser extent also in normotensives as several meta-analyses of interventional studies have shown...
October 19, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27715146/-64-cu-psma-617-pet-ct-imaging-of-prostate-adenocarcinoma-first-in-human-studies
#18
Bernhard Grubmüller, Richard P Baum, Enza Capasso, Aviral Singh, Yasaman Ahmadi, Peter Knoll, Andreas Floth, Sergio Righi, Shahin Zandieh, Carlo Meleddu, Shahrokh F Shariat, Hans Christoph Klingler, Siroos Mirzaei
AIM: The prostate-specific membrane antigen (PSMA) is a cell surface protein, which is overexpressed in nearly all cases of prostate cancer (PCa). PET imaging with (68)Ga-PSMA-HBED-CC has recently found widespread application in the diagnosis of recurrent PCa. In this study, the diagnostic potential of (64)Cu-labeled PSMA ligand (PSMA-617) PET in patients with PCa has been investigated. MATERIALS AND METHODS: The study was conducted simultaneously at two nuclear medicine centers, Austria (Vienna, Center 1) and Germany (Bad Berka, Center 2)...
October 7, 2016: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/27692834/localized-chromophobe-carcinomas-treated-by-nephron-sparing-surgery-have-excellent-oncologic-outcomes
#19
Pierre Bigot, Jean-Christophe Bernhard, Vincent Flamand, Inderbir Gill, Grégory Verhoest, Jean Baptiste Beauval, François Xavier Nouhaud, Evren Suer, Guillaume Ploussard, Jean François Hetet, Jérôme Rigaud, Eduard Baco, Stéphane Larré, Philippe Sebe, Nicolas Koutlidis, Aurélien Descazeaud, Masatoshi Eto, Arnaud Doerfler, Morgan Roupret, Nam Son Vuong, Boris Reix, Toru Matsugasumi, Adnan El Bakri, Laurence Albiges, Michel Soulié, Jean-Jacques Patard, Arnaud Méjean, Karim Bensalah
OBJECTIVE: To evaluate the oncologic outcomes of nephron-sparing surgery (NSS) for localized chromophobe renal cell carcinoma (cRCC). MATERIAL AND METHODS: We performed a multicenter international study involving the French Network for Research on Kidney Cancer (UroCCR) and 5 international teams. Data from 808 patients treated with NSS between 2004 and 2014 for non-clear cell RCCs were analyzed. RESULTS: We included 234 patients with cRCC...
September 27, 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27692178/the-calcium-sensing-receptor-in-health-and-disease
#20
G Díaz-Soto, A Rocher, C García-Rodríguez, L Núñez, C Villalobos
The extracellular calcium-sensing receptor (CaSR) is a unique G protein-coupled receptor (GPCR) activated by extracellular Ca(2+) and by other physiological cations including Mg(2+), amino acids, and polyamines. CaSR is the most important master controller of the extracellular Ca(2+) homeostatic system being expressed at high levels in the parathyroid gland, kidney, gut and bone, where it regulates parathyroid hormone (PTH) secretion, vitamin D synthesis, and Ca(2+) absorption and resorption, respectively. Gain and loss of function mutations in the CaSR are responsible for severe disturbances in extracellular Ca(2+) metabolism...
2016: International Review of Cell and Molecular Biology
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