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Urothelial carcinoma pathology

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https://www.readbyqxmd.com/read/28812022/histopathologic-differences-between-jewish-and-arab-population-in-israel-at-first-time-presentation-with-bladder-cancer
#1
Ofir Avitan, Zaher Bahouth, Sarel Halachmi, Sagi Shprits, Ismail Masarwa, Edmond Sabo, Boaz Moskovitz, Ofer Nativ
BACKGROUND: Pathology of urothelial carcinoma may vary in different populations at diagnosis. Our aim was to evaluate the histopathologic differences between Jewish and Arab patients in Israel at first diagnosis of urothelial cancer. PATIENTS AND METHODS: We retrospectively collected data of all patients with confirmed urothelial cancer, treated at our department between January 2010 and January 2015. We examined the distribution of the histopathologic data among the studied populations...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28803791/squamous-differentiation-predicts-poor-response-to-cisplatin-based-chemotherapy-and-unfavorable-prognosis-in-urothelial-carcinoma-of-the-urinary-bladder
#2
Akinori Minato, Naohiro Fujimoto, Tatsuhiko Kubo
OBJECTIVE: The efficacy of chemotherapy on UCSD is not known. This study was conducted to investigate the efficacy of cisplatin-based chemotherapy and prognosis of patients with UC with or without SD of the bladder. METHODS: Patients with invasive bladder cancer (clinical T3-4aN0M0) who were treated between March 2003 and March 2015 with 2 or 3 cycles of neoadjuvant chemotherapy followed by radical cystectomy were retrospectively evaluated. Treatment outcomes were compared for each pathologic type in UCSD and pure UC...
July 22, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28795841/serous-carcinoma-mimicking-primary-urothelial-carcinoma-on-clinical-evaluation-and-pathology-a-potential-diagnostic-pitfall
#3
Leili Mirsadraei, Alexey Hodkoff, Karra Jones, Ahmed Shabaik, A Karim Kader, Cheryl C Saenz, Rodolfo Montironi, David E Tacha, Oluwole Fadare, Donna E Hansel
CONTEXT: - Serous carcinoma of the gynecologic tract often involves the external bladder wall and can occasionally mimic primary urothelial carcinoma of the bladder. OBJECTIVE: - To define the spectrum of morphologic and immunohistochemical features that characterize serous carcinoma involving the bladder wall and its distinction from urothelial carcinoma. DESIGN: - We reviewed all cases of serous carcinoma secondarily involving the bladder wall from the University of California San Diego and Polytechnic Institute for histopathologic and immunohistochemical features...
August 10, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28789622/squamous-differentiation-in-patients-with-superficial-bladder-urothelial-carcinoma-is-associated-with-high-risk-of-recurrence-and-poor-survival
#4
Gang Li, Jianpeng Yu, Hualin Song, Shimiao Zhu, Libin Sun, Zhiqun Shang, Yuanjie Niu
BACKGROUND: The independent prognostic role of squamous differentiation in pT1 bladder urothelial carcinoma has not been reported in previous studies. This article describes the impact of squamous differentiation on tumor recurrence and survival, and whether this histologic variant could indeed alter definitive treatment, based on single center-based retrospective data. METHODS: Totally, we retrieved (1)1449 histologically confirmed pT1 bladder urothelial carcinoma patients without histologic variants; (2)227 pT1 bladder urothelial carcinoma patients with squamous differentiation in our institution, from May 2004 to Oct 2015...
August 8, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28768702/tumour-front-inflammation-and-necrosis-are-independent-prognostic-predictors-in-high-grade-urothelial-carcinoma-of-the-bladder
#5
Anjelica Hodgson, Bin Xu, Raj Satkunasivam, Michelle R Downes
AIMS: Inflammation and necrosis have been associated with prognosis in multiple epithelial malignancies. Our objective was to evaluate inflammation and necrosis in a cohort of patients with high-grade urothelial carcinomas of the bladder to determine their association with pathological parameters and their prognostic effect on relapse-free and disease-specific survival. METHODS: A retrospective cohort that underwent radical cystectomy for urothelial carcinomas (n=235) was evaluated for invasive front and central inflammation using the Klintrup-Makinen assessment method...
August 2, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28761589/the-role-of-urinary-cytology-when-diagnostic-workup-is-suspicious-for-upper-tract-urothelial-carcinoma-but-tumour-biopsy-is-nonconfirmatory
#6
David Horovitz, Yifan Meng, Jean V Joseph, Changyong Feng, Guan Wu, Hani Rashid, Edward M Messing
INTRODUCTION: We sought to determine the value of obtaining preoperative urinary cytology when diagnostic workup of an upper tract mass is suspicious for upper tract urothelial carcinoma (UTUC), but biopsy fails to confirm the diagnosis. METHODS: Using billing code data, 239 patients were identified as having undergone radical nephroureterectomy (RNU) by 16 urologists from September 29, 1998 to July 31, 2015. Of this group, 19 adult patients had a presumed preoperative diagnosis of UTUC in a native kidney, at least three months of followup, no history of concurrent radical cystectomy with RNU, and negative/non-diagnostic tissue biopsy...
July 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28753886/distinct-lipidomic-landscapes-associated-with-clinical-stages-of-urothelial-cancer-of-the-bladder
#7
Danthasinghe Waduge Badrajee Piyarathna, Thekkelnaycke M Rajendiran, Vasanta Putluri, Venkatrao Vantaku, Tanu Soni, Friedrich-Carl von Rundstedt, Sri Ramya Donepudi, Feng Jin, Suman Maity, Chandrashekar R Ambati, Jianrong Dong, Daniel Gödde, Stephan Roth, Stephan Störkel, Stephan Degener, George Michailidis, Seth P Lerner, Subramaniam Pennathur, Yair Lotan, Cristian Coarfa, Arun Sreekumar, Nagireddy Putluri
BACKGROUND: The first global lipidomic profiles associated with urothelial cancer of the bladder (UCB) and its clinical stages associated with progression were identified. OBJECTIVE: To identify lipidomic signatures associated with survival and different clinical stages of UCB. DESIGN, SETTING, AND PARTICIPANTS: Pathologically confirmed 165 bladder-derived tissues (126 UCB, 39 benign adjacent or normal bladder tissues). UCB tissues included Ta (n=16), T1 (n=30), T2 (n=43), T3 (n=27), and T4 (n=9); lymphovascular invasion (LVI) positive (n=52) and negative (n=69); and lymph node status N0 (n=28), N1 (n=11), N2 (n=9), N3 (n=3), and Nx (n=75)...
April 20, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28753881/platinum-based-neoadjuvant-chemotherapy-improves-oncological-outcomes-in-patients-with-locally-advanced-upper-tract-urothelial-carcinoma
#8
Shogo Hosogoe, Shingo Hatakeyama, Ayumu Kusaka, Itsuto Hamano, Hiromichi Iwamura, Naoki Fujita, Hayato Yamamoto, Yuki Tobisawa, Tohru Yoneyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Chikara Ohyama
BACKGROUND: Neoadjuvant chemotherapy (NAC) use for patients with locally advanced upper tract urothelial carcinoma (UTUC) is debatable. OBJECTIVE: To investigate the efficacy and safety of platinum-based NAC for locally advanced UTUC. DESIGN, SETTINGS, AND PARTICIPANTS: Of 233 consecutive patients who underwent radical nephroureterectomy, 55 patients received NAC (NAC group) and 138 patients did not (Ctrl group). OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: The two arms (Ctrl vs NAC) were matched using propensity scores to minimize selection bias...
April 7, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28753857/the-impact-of-plasmacytoid-variant-histology-on-the-survival-of-patients-with-urothelial-carcinoma-of-bladder-after-radical-cystectomy
#9
Qiang Li, Melissa Assel, Nicole E Benfante, Eugene J Pietzak, Harry W Herr, Machele Donat, Eugene K Cha, Timothy F Donahue, Bernard H Bochner, Guido Dalbagni
BACKGROUND: The clinical significance of the plasmacytoid variant (PCV) in urothelial carcinoma (UC) is currently lacking. OBJECTIVE: To compare clinical outcomes of patients with any PCV with that of patients with pure UC treated with radical cystectomy (RC). DESIGN, SETTING, AND PARTICIPANTS: We identified 98 patients who had pathologically confirmed PCV UC and 1312 patients with pure UC and no variant history who underwent RC at our institution between 1995 and 2014...
June 27, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28753846/the-landscape-of-whole-genome-alterations-and-pathologic-features-in-genitourinary-malignancies-an-analysis-of-the-cancer-genome-atlas
#10
Mark W Ball, Michael A Gorin, Charles G Drake, Hans J Hammers, Mohamad E Allaf
BACKGROUND: The accumulation of somatic genetic alterations drives carcinogenesis. Little is known, however, about how the level of genetic alteration across an entire cancer genome affects tumor grade, stage or survival. OBJECTIVE: To investigate the influence of somatic mutation count (MC) and copy number variation (CNV) on pathologic and oncologic outcomes in patients with genitourinary malignancies in The Cancer Genome Atlas (TCGA). DESIGN, SETTING, AND PARTICIPANTS: TCGA data sets for adrenocortical carcinoma (ACC), bladder urothelial carcinoma (BLCA), chromophobe renal cell carcinoma (RCC; KICH), clear cell RCC (KIRC), papillary RCC (KIRP), pheochromocytoma and paraganglioma (PCPG), prostate adenocarcinoma (PRAD), and testis germ cell tumor (TGCT) were accessed via cBioportal...
February 8, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28753840/caveolin-1-expression-in-upper-tract-urothelial-carcinoma
#11
David D'Andrea, Marco Moschini, Beat Foerster, Mohammad Abufaraj, Vitaly Margulis, Jose Karam, Yair Lotan, Jay Raman, Romain Mathieu, Morgan Rouprêt, Pierre I Karakiewicz, Alberto Briganti, Andrea Haitel, Sharhrokh F Shariat
BACKGROUND: Improvement in postoperative risk stratification of upper tract urothelial carcinoma (UTUC) is required to better predict outcomes and counsel patients on adjuvant treatment. OBJECTIVE: To validate the association between caveolin-1 and oncological outcomes in patients treated with radical nephroureterectomy (RNU) for UTUC. DESIGN, SETTING, AND PARTICIPANTS: Caveolin-1 expression was evaluated via immunochemistry on a tissue microarray from 621 patients...
July 1, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28753826/programmed-death-ligand-1-expression-in-upper-tract-urothelial-carcinoma
#12
Stephanie L Skala, Tzu-Ying Liu, Aaron M Udager, Alon Z Weizer, Jeffrey S Montgomery, Ganesh S Palapattu, Javed Siddiqui, Xuhong Cao, Kristina Fields, Ahmed E Abugharib, Moaaz Soliman, Khaled S Hafez, David Miller, Cheryl T Lee, Ajjai Alva, Arul M Chinnaiyan, Todd M Morgan, Daniel E Spratt, Hui Jiang, Rohit Mehra
BACKGROUND: Urothelial carcinoma (UC) is the most common malignancy of the urinary tract. Upper tract (renal pelvis and ureter) urothelial carcinomas (UTUC) account for approximately 5% of UCs but a significant subset are invasive and associated with poor clinical outcomes. OBJECTIVE: To evaluate programmed death-ligand 1 (PD-L1) expression in UTUC. DESIGN, SETTING, AND PARTICIPANTS: UTUC cases from 1997-2016 were retrospectively identified from the surgical pathology database at a single large academic institution...
December 13, 2016: European Urology Focus
https://www.readbyqxmd.com/read/28753817/detection-of-lymph-node-metastasis-in-patients-with-bladder-cancer-using-maximum-standardised-uptake-value-and-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-results-from-a-high-volume-centre-including-long-term-follow-up
#13
Stefan Vind-Kezunovic, Kirsten Bouchelouche, Pia Ipsen, Søren Høyer, Cathrine Bell, Jørgen Bjerggaard Jensen
BACKGROUND: Preoperative staging with (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET) combined with computed tomography (CT) is used for the evaluation of metastatic disease in patients with invasive bladder cancer. The use of quantification with maximum standardized uptake value (SUVmax) of regional lymph nodes (LNs) has been suggested to increase the diagnostic ability for detection of malignancy. OBJECTIVE: Assessment of the utility and clinical relevance of SUVmax in (18)F-FDG PET in detecting regional nodal metastases in patients considered for radical cystectomy...
June 23, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28750448/-role-of-the-human-erbb-family-receptors-in-urothelial-carcinoma-of-the-bladder-mrna-expression-status-and-prognostic-relevance
#14
Philipp Erben, Felix Wezel, Ralph Wirtz, Thomas Martini, Doron Stein, Cleo-Aaron Weis, Arndt Hartmann, Christian Bolenz
Background Altered expression of epidermal growth factor (EGF) family (ErbB) receptors in urothelial carcinoma of the urinary bladder (UCB) has been associated with adverse outcomes. Given the limited treatment options in UCB, EGFR and HER2 (ERBB2) represent established therapeutic targets in other entities. We assessed the expression of ErbB family receptors (ERBB1 - 4) on mRNA levels in correlation with histopathological and clinical parameters in patients treated with radical cystectomy (RC). Methods 94 patients (female = 22; male = 72; median age: 66...
August 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/28738880/level-of-mitoses-in-non-muscle-invasive-papillary-urothelial-carcinomas-pta-and-pt1-at-initial-bladder-biopsy-is-a-simple-and-powerful-predictor-of-clinical-outcome-a-multi-center-study-in-south-korea
#15
Ji Eun Kwon, Nam Hoon Cho, Yeong-Jin Choi, So Dug Lim, Yong Mee Cho, Sun Young Jun, Sanghui Park, Young A Kim, Sung-Sun Kim, Mi Sun Choe, Jung-Dong Lee, Dae Yong Kang, Jae Y Ro, Hyun-Jung Kim
BACKGROUND: Histologic grade is the most important predictor of the clinical outcome of non-muscle invasive (Ta, T1) papillary urothelial carcinoma (NMIPUCa), but its ambiguous criteria diminish its power to predict recurrence/progression for individual patients. We attempted to find an objective and reproducible histologic predictor of NMIPUCa that correlates well with the clinical outcome. METHODS: A total of 296 PUCas were collected from the Departments of Surgical Pathology of 11 institutions in South Korea...
July 24, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28732373/impact-of-preoperative-diagnostic-turbt-on-progression-free-survival-in-patients-with-pathological-high-grade-stage-t3-t4-bladder-urothelial-carcinoma
#16
Haichao Huang, Zhenhua Liu, Xin Li, Wei Li, Jinchun Xing, Wei Yu, Jie Jin
Transurethral bladder tumor resection (TURBT) reportedly increases the circulating tumor cell count in patients with urothelial carcinoma of the bladder (UCB). To determine whether diagnostic TURBT leads to poorer progression-free survival (PFS) than diagnostic cystoscopic biopsy, we retrospectively reviewed the records of 96 consecutive primary pathological high-grade, stage T3/T4 UCB patients treated with radical cystectomy (RC) between January 2009 to December 2013. Clinicopathological features were collected from the medical records...
July 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28709887/frequency-and-prognostic-value-of-pten-loss-in-patients-with-upper-tract-urothelial-carcinoma-treated-with-radical-nephroureterectomy
#17
Malte Rieken, Shahrokh F Shariat, Jose A Karam, Beat Foerster, Francesca Khani, Kilian Gust, Mohammad Abufaraj, Christopher G Wood, Alon Z Weizer, Jay D Raman, Charles C Guo, Nathalie Rioux-Leclercq, Andrea Haitel, Karim Bensalah, Yair Lotan, Alexander Bachmann, Angelo M De Marzo, Brian D Robinson, Vitaly Margulis
PURPOSE: The frequency and prognostic significance of phosphatase and tensin homolog (PTEN) protein expression in upper tract urothelial carcinoma (UTUC) have not been investigated yet in large studies. To analyze PTEN protein status and its association with disease recurrence and survival outcomes in a large, multi-institutional UTUC cohort. MATERIALS AND METHODS: Retrospective analysis of 611 patients with UTUC treated with radical nephroureterectomy (RNU) between 1991 and 2008 at seven institutions...
July 11, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28694418/-a-case-of-long-survival-in-aggressively-growing-small-cell-carcinoma-of-the-bladder-successfully-treated-by-combined-chemotherapy-of-methotrexate-etoposide-and-cisplatin
#18
Ryosuke Jikuya, Kouta Washimi, Masato Yasui, Akihito Hashizume, Tomoyuki Tatenuma, Nobuhiko Mizuno, Kentaro Muraoka, Susumu Umemoto, Masaki Kawai, Takeshi Kishida
A 74-year-old man underwent transurethral resection for a bladder tumor (TURBT). The pathological diagnosis was urothelial carcinoma, grade 3 pT2 at least. He desired preservation of the bladder. Thus, MEC (methotrexate 100-150 mg/body (day 1), etoposide 100 mg/m2 (day 2-4), cisplatin 20 mg/m2 (day 2-6)) chemotherapy was administered for 2 courses. The next year, he had a relapse in the bladder, and the pathological diagnosiswasurothelial carcinoma, grade 2 pTa and pTis. He underwent Calmette-Guerin Bacillus (BCG) immunotherapy for 6 courses that resulted in a complete response without recurrence for 6 years...
June 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28694147/predictive-and-prognostic-value-of-preoperative-thrombocytosis-in-upper-tract-urothelial-carcinoma
#19
Beat Foerster, Marco Moschini, Mohammad Abufaraj, Francesco Soria, Kilian M Gust, Morgan Rouprêt, Pierre I Karakiewicz, Alberto Briganti, Michael Rink, Luis Kluth, Romain Mathieu, Vitaly Margulis, Yair Lotan, Atiqullah Aziz, Hubert John, Shahrokh F Shariat
PURPOSE: The purpose of this study was to evaluate the predictive and prognostic role of preoperative thrombocytosis (TC) in upper tract urothelial carcinoma (UTUC) after radical nephroureterectomy (RNU) in a large multi-institutional cohort of patients. METHODS: Records of 2492 patients undergoing RNU for non-metastatic UTUC between 1990 and 2008 were retrospectively analyzed. Preoperative TC was defined as a platelet count > 400 × 10(9)/L, irrespective of gender type...
June 19, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28668287/prognostic-value-of-pd-1-and-pd-l1-expression-in-patients-with-high-grade-upper-tract-urothelial-carcinoma
#20
Laura-Maria Krabbe, Barbara Heitzplatz, Sina Preuss, Ryan C Hutchinson, Solomon L Woldu, Nirmish Singla, Martin Boegemann, Christopher G Wood, Jose A Karam, Alon Z Weizer, Jay D Raman, Mesut Remzi, Nathalie Rioux-Leclercq, Andrea Haitel, Leonid M Rapoport, Peter V Glybochko, Marco Roscigno, Christian Bolenz, Karim Bensalah, Arthur I Sagalowsky, Shahrokh F Shariat, Yair Lotan, Evanguelos Xylinas, Vitaly Margulis
PURPOSE: To investigate the prognostic value of PD-1 and PD-L1 expression in patients with high-grade upper tract urothelial carcinoma (UTUC). PATIENTS AND METHODS: Tissue microarrays of 423 patients with extirpative surgery for high-grade UTUC from the International UTUC collaboration were stained for PD-1 and PD-L1 (antibodies: Cell Marque, NAT105 diluted 1:250 and Cell Signaling, E1L3N© prediluted) via immunohistochemistry. A staining percentage of ≥1% of tumor-infiltrating lymphocytes (PD-1) and tumor cells (PD-L1) was considered positive...
June 28, 2017: Journal of Urology
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