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Urothelial carcinoma pathology

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https://www.readbyqxmd.com/read/28709887/frequency-and-prognostic-value-of-pten-loss-in-patients-with-upper-tract-urothelial-carcinoma-treated-with-radical-nephroureterectomy
#1
Malte Rieken, Shahrokh F Shariat, Jose A Karam, Beat Foerster, Francesca Khani, Kilian Gust, Mohammad Abufaraj, Christopher G Wood, Alon Z Weizer, Jay D Raman, Charles C Guo, Nathalie Rioux-Leclercq, Andrea Haitel, Karim Bensalah, Yair Lotan, Alexander Bachmann, Angelo M De Marzo, Brian D Robinson, Vitaly Margulis
PURPOSE: The frequency and prognostic significance of phosphatase and tensin homolog (PTEN) protein expression in upper tract urothelial carcinoma (UTUC) have not been investigated yet in large studies. To analyze PTEN protein status and its association with disease recurrence and survival outcomes in a large, multi-institutional UTUC cohort. MATERIALS AND METHODS: Retrospective analysis of 611 patients with UTUC treated with radical nephroureterectomy (RNU) between 1991 and 2008 at seven institutions...
July 11, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28694418/-a-case-of-long-survival-in-aggressively-growing-small-cell-carcinoma-of-the-bladder-successfully-treated-by-combined-chemotherapy-of-methotrexate-etoposide-and-cisplatin
#2
Ryosuke Jikuya, Kouta Washimi, Masato Yasui, Akihito Hashizume, Tomoyuki Tatenuma, Nobuhiko Mizuno, Kentaro Muraoka, Susumu Umemoto, Masaki Kawai, Takeshi Kishida
A 74-year-old man underwent transurethral resection for a bladder tumor (TURBT). The pathological diagnosis was urothelial carcinoma, grade 3 pT2 at least. He desired preservation of the bladder. Thus, MEC (methotrexate 100-150 mg/body (day 1), etoposide 100 mg/m2 (day 2-4), cisplatin 20 mg/m2 (day 2-6)) chemotherapy was administered for 2 courses. The next year, he had a relapse in the bladder, and the pathological diagnosiswasurothelial carcinoma, grade 2 pTa and pTis. He underwent Calmette-Guerin Bacillus (BCG) immunotherapy for 6 courses that resulted in a complete response without recurrence for 6 years...
June 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28694147/predictive-and-prognostic-value-of-preoperative-thrombocytosis-in-upper-tract-urothelial-carcinoma
#3
Beat Foerster, Marco Moschini, Mohammad Abufaraj, Francesco Soria, Kilian M Gust, Morgan Rouprêt, Pierre I Karakiewicz, Alberto Briganti, Michael Rink, Luis Kluth, Romain Mathieu, Vitaly Margulis, Yair Lotan, Atiqullah Aziz, Hubert John, Shahrokh F Shariat
PURPOSE: The purpose of this study was to evaluate the predictive and prognostic role of preoperative thrombocytosis (TC) in upper tract urothelial carcinoma (UTUC) after radical nephroureterectomy (RNU) in a large multi-institutional cohort of patients. METHODS: Records of 2492 patients undergoing RNU for non-metastatic UTUC between 1990 and 2008 were retrospectively analyzed. Preoperative TC was defined as a platelet count > 400 × 10(9)/L, irrespective of gender type...
June 19, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28668287/prognostic-value-of-pd-1-and-pd-l1-expression-in-patients-with-high-grade-upper-tract-urothelial-carcinoma
#4
Laura-Maria Krabbe, Barbara Heitzplatz, Sina Preuss, Ryan C Hutchinson, Solomon L Woldu, Nirmish Singla, Martin Boegemann, Christopher G Wood, Jose A Karam, Alon Z Weizer, Jay D Raman, Mesut Remzi, Nathalie Rioux-Leclercq, Andrea Haitel, Leonid M Rapoport, Peter V Glybochko, Marco Roscigno, Christian Bolenz, Karim Bensalah, Arthur I Sagalowsky, Shahrokh F Shariat, Yair Lotan, Evanguelos Xylinas, Vitaly Margulis
PURPOSE: To investigate the prognostic value of PD-1 and PD-L1 expression in patients with high-grade upper tract urothelial carcinoma (UTUC). PATIENTS AND METHODS: Tissue microarrays of 423 patients with extirpative surgery for high-grade UTUC from the International UTUC collaboration were stained for PD-1 and PD-L1 (antibodies: Cell Marque, NAT105 diluted 1:250 and Cell Signaling, E1L3N© prediluted) via immunohistochemistry. A staining percentage of ≥1% of tumor-infiltrating lymphocytes (PD-1) and tumor cells (PD-L1) was considered positive...
June 28, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28634017/the-over-time-conditional-survival-of-intravesical-recurrence-in-upper-tract-urothelial-carcinoma
#5
Keisuke Shigeta, Eiji Kikuchi, Masayuki Hagiwara, Toshiyuki Ando, Ryuichi Mizuno, Takayuki Abe, Shuji Mikami, Akira Miyajima, Ken Nakagawa, Mototsugu Oya
PURPOSE: Since a conditional survival (CS) analysis provides better estimates of survival times at each follow-up, we aimed to assess changes in conditional intravesical recurrence-free survival (IVRFS) rates after radical nephroureterectomy (RNU) and how the impact of well-known risk factors evolves over time, particularly in localized upper tract urothelial carcinoma (UTUC) patients. MATERIALS AND METHODS: We identified 364 patients with Ta-3N0M0 UTUC who underwent open or laparoscopic RNU at our three institutions...
June 17, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28626955/expression-profile-of-urothelial-transcription-factors-in-bladder-biopsies-with-interstitial-cystitis
#6
Kanya Kaga, Ken-Ichi Inoue, Mayuko Kaga, Tomohiko Ichikawa, Tomonori Yamanishi
OBJECTIVES: To characterize interstitial cystitis pathology based on the expression profile of urothelial tissue-specific master transcription factors. METHODS: Bladder carcinoma cell lines derived from the urothelial stem cells (epithelial or mesenchymal) were used to identify candidate urothelial master transcription factors. Gene expression was measured with quantitative reverse transcription polymerase chain reaction. From the initial screening of 170 transcription factors (human homologs of Drosophila segmentation genes and known master transcription factors from a database), 28 transcription factors were selected...
June 18, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28606776/extraperitoneal-laparoscopic-radical-nephroureterectomy-and-lymph-node-dissection-in-modified-supine-position
#7
Pengchao Li, Jun Tao, Xiaheng Deng, Chao Qin, Yidong Cheng, Peng Li, Jiexiu Zhang, Yongke Cao, Xiao Yang, Chengdi Yang, Qiang Lu
Objective To explore the feasibilty of extraperitoneal laparoscopic radical nephroureterectomy (RNU) and lymph node dissection in modified supine position for managing urothelial carcinomas in renal pelvis or upper 2/3 ureter. Subjects / Patients and Methods Consecutively from January 2014 to October 2015, 15 patients with high-risk urothelial carcinoma in renal pelvis or upper 2/3 ureter underwent extraperitoneal laparoscopic radical nephroureterectomy (EL-RNU) and extraperitoneal laparoscopic lymph node dissection (EL-LND)...
June 9, 2017: Urology
https://www.readbyqxmd.com/read/28604991/ureteroscopy-in-the-diagnosis-of-upper-tract-transitional-cell-cancer-a-10-year-experience-providing-outcome-data-for-informed-consent
#8
Luke Hanna, Vera Chung, Ahmed Ali, Robert Ritchie, Ann Rogers, Mark Sullivan, Stephen Keoghane
PURPOSE: The aim of the study was to assess the effectiveness of ureteroscopy and biopsy in the diagnosis and management of upper tract urothelial carcinoma. METHODS: We retrospectively collated data from pathology, radiology and operating theatre data sets from two large UK hospitals. During the 10-year period examined, 160 patients underwent ureteroscopy prior to nephro-ureterectomy (NU)/distal ureterectomy (DU). RESULTS: Of the 160 patients identified, 140 were ureteroscopically evaluated and biopsied, 104 (74...
June 7, 2017: Urologia
https://www.readbyqxmd.com/read/28600503/transcriptome-sequencing-identifies-anln-as-a-promising-prognostic-biomarker-in-bladder-urothelial-carcinoma
#9
Shuxiong Zeng, Xiaowen Yu, Chong Ma, Ruixiang Song, Zhensheng Zhang, Xiaoyuan Zi, Xin Chen, Yang Wang, Yongwei Yu, Junjie Zhao, Rongchao Wei, Yinghao Sun, Chuanliang Xu
The prognosis of bladder urothelial carcinoma (BLCA) varies greatly even for patients with similar pathological characteristics. We conducted transcriptome sequencing on ten pairs of BLCA samples and adjacent normal tissues to identify differentially expressed genes. Anillin (ANLN) was identified as a transcript that was significantly up-regulated in BLCA samples compared with normal tissues. Prognostic power of candidate gene was studied using qRT-PCR and immunohistochemistry on 40 and 209 patients, respectively...
June 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28596510/mex3a-expression-and-survival-analysis-of-bladder-urothelial-carcinoma
#10
Jing-Wen Shi, Ying Huang
OBJECTIVE: Bladder urothelial carcinoma is a common tumor in humans and a multifactorial disease. The gene mex3a is associated with tumor formation and may promote cell proliferation and migration. Therefore, this study aimed to determine the relationship between mex3a and bladder urothelial carcinoma. METHODS: The clinical and RNA sequencing expression data in patients with bladder urothelial carcinoma were downloaded from the The Cancer Genome Atlas data portal...
June 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28583528/human-polyomavirus-is-associated-with-earlier-onset-of-upper-urinary-tract-urothelial-carcinoma-in-patients-after-kidney-transplantation
#11
H L Luo, Y T Chen, S C Huang, T C Chen, P H Chiang, S S Lin, Y T Cheng
OBJECTIVES: Polyomavirus has been reported to be oncogenic due to viral integration into the human genome. A relatively high prevalence of upper urinary tract urothelial carcinoma (UTUC) was noted after kidney transplantation (KT) in Taiwan. However, little was known about the impact of polyomavirus on the urothelial cancer behavior. Therefore, the aim of this study is to analyze the characteristics of polyomavirus-related UTUC after KT. METHODS: From 2005 to 2014, 27 patients were found to have UTUCs after KT...
June 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28578357/is-survival-after-radical-cystectomy-for-bladder-cancer-in-saudi-patients-different-from-that-of-western-patients
#12
Alaa Mokhtar, Mohamed Matar Al, Waleed Mohamad Al, Khalid Al Othman, Said A Kattan, Mohammed Faihan Al
BACKGROUND: Although radical cystectomy (RC) is considered the gold standard treatment of muscle invasive bladder cancer, nearly half of patients develop metastases and ultimately die within 2 years. OBJECTIVE: To assess survival, evaluate different prognostic factors that may affect disease-free survival (DFS) in Saudi patients after RC for carcinoma of the bladder and to compare our results with those of Western countries. DESIGN: Retrospective chart review...
May 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/28576425/-correlation-of-genetic-and-cytogenetic-alterations-in-pathological-aggressiveness-urothelial-carcinoma-of-the-bladder-performance-of-bca-1-a-mini-array-comparative-genomic-hybridisation-based-test
#13
P Léon, G Cancel Tassin, K Sighar, E Compérat, C Gaffory, V Ondet, S Hugonin, M Audouin, S Doizi, O Traxer, C Ciofu, M Rouprêt, R Lacave, O Cussenot
INTRODUCTION: Urothelial carcinomas are the fourth leading cause of cancer in humans. Their incidence is increasing by more than 50% in 25 years. The superficial forms (70% cases) require a close active surveillance to identify frequent recurrences and progression to invasive stage. Our main goal was to identify prognostic molecular markers for bladder cancer that could be used alone or in combination in routine clinical practice. In this aim, we evaluated the capability of the BCA-oligo test based on a CGH array to correctly classify tumoral grade/stage...
June 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28556525/upper-urinary-tract-washings-outperform-voided-urine-specimens-to-detect-upper-tract-high-grade-urothelial-carcinoma
#14
M Lisa Zhang, Dorothy L Rosenthal, Christopher J VandenBussche
BACKGROUND: Cytological examination of voided urine (VU) can reliably diagnose high-grade urothelial carcinoma (HGUC) of the lower urinary tract, but its value in the diagnosis of upper tract HGUC (UTHGUC) is less well-established. To clarify the utility of VU in the setting of UTHGUC, we examined urinary specimens from patients with UTHGUC on follow-up surgical pathology. METHODS: 52 VU specimens (47 patients) with subsequent biopsy-proven UTHGUC were identified over a 12-year period; 32 had a corresponding upper tract urinary washing (UW) specimen...
May 28, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28556470/contrast-enhanced-ultrasound-differentiation-between-low-and-high-grade-bladder-urothelial-carcinoma-and-correlation-with-tumor-microvessel-density
#15
Suping Guo, Pan Xu, Aiyun Zhou, Gongxian Wang, Weimin Chen, Jinhong Mei, Fan Xiao, Juan Liu, Cheng Zhang
OBJECTIVES: Time-intensity curves (TICs) of contrast-enhanced ultrasound (CEUS) were analyzed retrospectively to differentiate between low-grade and high-grade bladder urothelial carcinoma, and to investigate correlation with tumor microvessel density (MVD). METHODS: The data of 105 patients with pathologically confirmed bladder urothelial carcinoma (55 low-grade and 50 high-grade) were reviewed. Lesions were examined before surgery using conventional ultrasound and CEUS with TIC analysis...
May 27, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28554752/diagnostic-utility-of-ki-67-immunohistochemistry-in-small-endoscopic-biopsies-of-the-ureter-and-renal-pelvis
#16
Yuichi Koyama, Teppei Morikawa, Jimpei Miyakawa, Yu Miyama, Tohru Nakagawa, Yukio Homma, Masashi Fukayama
Diagnosis of upper urinary tract urothelial carcinoma in ureteroscopic biopsies is challenging. Therefore, an immunohistochemical marker that can differentiate between malignant and benign urothelium and predict final pathological features is necessary. In this study, we investigated Ki-67 expression in 26 ureteroscopic biopsies of the ureter and renal pelvis diagnosed with urothelial carcinoma (UC) and in 13 biopsies with non-neoplastic urothelium, using digital image analysis. The median Ki-67 labeling index was 1...
April 20, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28549474/a-rare-presentation-of-metastatic-prostate-cancer-initially-a-suspect-for-urothelial-cell-carcinoma-of-the-ureter-a-case-report
#17
Ho Seok Chung, Myung Soo Kim, Yang Hyun Cho, Eu Chang Hwang, Seung Il Jung, Taek Won Kang, Dong Deuk Kwon, Suk Hee Heo, Chan Choi
BACKGROUND: The most common metastatic sites of prostate cancer are the lymph nodes and bone. Ureteral metastasis from prostate cancer is very unusual and only a few cases have been reported. CASE PRESENTATION: We describe a 76-year-old male with ureteral metastasis of prostate cancer along with a review of the literature. Initially, based on the diagnostic evaluation, urothelial cell carcinoma of the left distal ureter was suspected. Nephroureterectomy with bladder cuff excision was performed...
May 26, 2017: BMC Urology
https://www.readbyqxmd.com/read/28548125/next-generation-sequencing-based-molecular-characterization-of-primary-urinary-bladder-adenocarcinoma
#18
Somak Roy, Dinesh Pradhan, Wayne L Ernst, Stephanie Mercurio, Yana Najjar, Rahul Parikh, Anil V Parwani, Reetesh K Pai, Rajiv Dhir, Marina N Nikiforova
Primary bladder adenocarcinoma is a rare and aggressive tumor with poor clinical outcomes and no standard of care therapy. Molecular biology of this tumor is unknown due to the lack of comprehensive molecular profiling studies. The study aimed to identify genomic alterations of clinical and therapeutic significance using next-generation sequencing and compare genomic profile of primary bladder adenocarcinoma with that of high-grade urothelial carcinoma and colorectal adenocarcinoma. A cohort of 15 well-characterized primary bladder adenocarcinoma was subjected to targeted next-generation sequencing for the identification of mutations and copy-number changes in 51 cancer-related genes...
May 26, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28545841/oncologic-outcomes-for-patients-with-residual-cancer-at-cystectomy-following-neoadjuvant-chemotherapy-a-pathologic-stage-matched-analysis
#19
Bimal Bhindi, Igor Frank, Ross J Mason, Robert F Tarrell, Prabin Thapa, John C Cheville, Brian A Costello, Lance C Pagliaro, R Jeffrey Karnes, R Houston Thompson, Matthew K Tollefson, Stephen A Boorjian
While it has been demonstrated that receipt of neoadjuvant chemotherapy (NAC) before radical cystectomy (RC) improves survival compared to RC alone, the driving factor for this benefit may be from patients with ypT0 status at surgery. Meanwhile, the implications of having residual urothelial carcinoma of the bladder (rUCB) at RC after NAC are less clear. We therefore evaluated whether survival differed between patients with rUCB at RC after NAC and stage-matched controls who underwent RC alone. Patients who underwent NAC + RC (n = 180) were matched to controls who underwent RC alone (n=324) on the basis of pT and pN stage, margin status, and year of RC...
May 22, 2017: European Urology
https://www.readbyqxmd.com/read/28506733/variant-morphology-in-upper-urinary-tract-urothelial-carcinoma-a-fourteen-year-case-series-of-biopsy-and-resection-specimens
#20
Hiroyuki Hayashi, Steven Mann, Chia-Sui Kao, David Grignon, Muhammad T Idrees
Upper urinary tract urothelial carcinoma exhibiting variant morphology, especially in higher-grade tumors, is a recognized phenomenon but has not been comparatively studied in biopsy versus resection material. We studied the morphologic patterns and clinicopathological features, and provide a comparison between biopsy and resection specimens. Consultation cases were evaluated separately to investigate for possible consultation bias. A total of 383 in-house cases from 352 patients including 314 resection specimens and 69 biopsies from 2001-2014 were reviewed from a single institution...
May 12, 2017: Human Pathology
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