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Urothelial carcinoma pathology

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https://www.readbyqxmd.com/read/29781067/rare-plasmacytoid-urothelial-carcinoma-of-the-bladder-two-case-reports
#1
Tuba Devrim, Fatih Atac, Canan Altunkaya, Ayse Ozbek, Gulhan Ozdemir, Merve Eryol
Plasmacytoid urothelial carcinoma is a rare and aggressive form of urothelial carcinoma characterized with delayed presentation and poor prognosis. Very few cases of this carcinoma have been reported in the literature. Here, we report and discuss two cases of bladder plasmacytoid urothelial carcinoma of a 57-year-old male presentedwith renal colic, and a 33-year-old female presented with macroscopic hematuria. Pathologic examinations of thetransurethral biopsies revealed urothelial carcinoma with plasmacytoid appearance...
May 21, 2018: Urology Journal
https://www.readbyqxmd.com/read/29780656/primary-leiomyosarcoma-of-the-colon-a-report-of-two-cases-review-of-the-literature-and-association-with-immunosuppression-for-ibd-and-rheumatoid-arthritis
#2
Jessica S Crystal, Kristin Korderas, David Schwartzberg, Steven C Tizio, Min Zheng, Glenn Parker
Primary leiomyosarcomas (LMS) of the colon are rare and aggressive neoplasms and have been infrequently reported in the literature. These tumors are more aggressive and have poorer prognoses than adenocarcinoma of the colon and are often mistaken as such on initial evaluation. While the former has a clear association with inflammatory bowel disease (IBD), this correlation is not known to exist with LMS and IBD. Nor is there a known link between LMS and the immunosuppression for IBD, despite the known association between malignancy and immunosuppression for other diseases...
2018: Case Reports in Surgery
https://www.readbyqxmd.com/read/29776013/prognostic-pathologic-factors-in-radical-cystectomy-after-neoadjuvant-chemotherapy
#3
Fadi Brimo, Michelle R Downes, Tamara Jamaspishvili, David Berman, Guliz A Barkan, Daniel Athanazio, Schuharazad Abro, Kash Visram, Asli Yilmaz, Shraddha Solanki, Elan Hahn, Robert Siemens, Wassim Kassouf, Kiril Trpkov
We undertook a systematic evaluation of the prognostic value of numerous histologic factors in 165 radical cystectomies (RC) of patients with invasive urothelial carcinoma who underwent surgery after neoadjuvant chemotherapy (NAC). Tumor regression grade (TRG) and therapy-related stromal and epithelial changes were also recorded. Locally advanced disease (≥pT2 and/or pN+) was present in 64% of patients, 22% had no evidence of residual carcinoma (pT0+pN0) and 28% had no evidence of residual muscle invasive carcinoma (≤pT1+N0)...
May 18, 2018: Histopathology
https://www.readbyqxmd.com/read/29772616/-recurrent-urothelial-carcinoma-in-the-uretero-vesical-junction-treated-with-partial-ureterectomy-and-ureteroneocystostomy-during-long-term-follow-up-a-case-report
#4
Soichiro Shimura, Kazumasa Matsumoto, Ken-Ichi Tabata, Tetsuo Fujita, Masatsugu Iwamura
A 54-year-old woman who had been treated with transurethral resection of bladder tumor for nonmuscle invasive urothelial carcinoma approximately nine years before presented with gross hematuria. Cystoscopy demonstrated a papillary tumor at the left side of the ureteral orifice. Magnetic resonance imaging showed a 1.3 cm non-muscle invasive lesion in the lower ureter from the ureteral orifice. She suffered from connective tissue disease treated with steroids. To avoid renal failure, we performed partial ureterectomy and ureteroneocystostomy...
April 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29762839/circulating-uca1-is-highly-expressed-in-patients-with-systemic-lupus-erythematosus-and-promotes-the-progression-through-the-akt-pathway
#5
C-R Jiang, T-H Li
OBJECTIVE: To investigate the role of Urothelial Carcinoma Associated 1 (UCA1) during the progression of systemic lupus erythematosus (SLE) and the underlying mechanism. PATIENTS AND METHODS: UCA1 expression in peripheral blood of SLE patients, as well as the expression of protein kinase B (AKT) in the peripheral blood mononuclear cell (PBMC), was detected by qRT-PCR. Expression differences in UCA1 and AKT between different groups were compared by t-test or univariate analysis...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29762827/upregulation-of-long-non-coding-rna-hnf1a-as1-is-associated-with-poor-prognosis-in-urothelial-carcinoma-of-the-bladder
#6
Y-H Wang, Y-H Liu, Y-J Ji, Q Wei, T-B Gao
OBJECTIVE: Long noncoding RNAs (lncRNAs) play important roles in the pathogenesis of bladder cancer. A recent study reported that lncRNA HNF1A-AS1 (HNF1A-AS1) was upregulated in urothelial carcinoma of the bladder (UCB) and served as a tumor promoter. However, the clinical significance of HNF1A-AS1 in the prognosis of patients with UCB was poorly understood. This work was designed to investigate the relationship between HNF1A-AS1 expression level and the prognosis of UCB. PATIENTS AND METHODS: Relative expression levels of HNF1A-AS1 in UCB tissues were determined by qRT-PCR...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29761225/pathological-characteristics-and-prognostic-indicators-of-different-histopathological-types-of-urinary-bladder-cancer-following-radical-cystectomy-in-a-large-single-center-egyptian-cohort
#7
Jeremy W Martin, Simone L Vernez, Yair Lotan, Ahmed Abdelhalim, Rahul Dutta, Ahmed Shokeir, Hassan Abol-Enein, Ahmed Mosbah, Mohamed Ghoneim, Ramy F Youssef
OBJECTIVE: To evaluate differences in pathological features and prognostics across four bladder cancer histopathological types: urothelial carcinoma (UC), urothelial carcinoma with variant histology (UCV), squamous cell carcinoma (SCC) and adenocarcinoma (ADC), utilizing a large cohort of radical cystectomy (RC) patients. METHODS: A retrospective analysis of patients who underwent RC at a single institution in Egypt between 1997 and 2004 was performed. Kaplan-Meier and multivariable analyses were performed to evaluate the prognostic significance of pathological features including tumor stage, grade, lymphovascular invasion (LVI), and lymph node (LN) involvement in the different subtypes on disease-free survival (DFS)...
May 14, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29750666/pd-l1-immunohistochemistry-assay-concordance-in-urothelial-carcinoma-of-the-bladder-and-hypopharyngeal-squamous-cell-carcinoma
#8
Anjelica Hodgson, Elzbieta Slodkowska, Achim Jungbluth, Stanley K Liu, Danny Vesprini, Danny Enepekides, Kevin Higgins, Nora Katabi, Bin Xu, Michelle R Downes
Programmed death ligand-1 (PD-L1) immunohistochemistry is used to guide treatment decisions regarding the use of checkpoint immunotherapy in the management of urothelial carcinoma of the bladder and hypopharyngeal (HP) squamous cell carcinoma. With increasing PD-L1 testing options, a need has arisen to assess the analytical comparability of diagnostic assays in order to develop a more sustainable testing strategy. Using tissue microarrays, PD-L1 expression in tumor cells (TCs) and immune cells (ICs) was manually scored in 197 cases and 27 cases of bladder and HP cancer, respectively...
May 10, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29748589/prognostic-impact-of-tumor-infiltrating-lymphocytes-on-patients-with-metastatic-urothelial-carcinoma-receiving-platinum-based-chemotherapy
#9
Hui-Shan Huang, Harvey Yu-Li Su, Pei-Hsu Li, Po-Hui Chiang, Cheng-Hua Huang, Chien-Hsu Chen, Meng-Che Hsieh
The impact of tumor infiltrating lymphocytes (TILs) on survival was confirmed in various cancer types. Our study aims to investigate the prognostic role of TILs on survival in patients with metastatic urothelial carcinoma (mUC) receiving platinum based chemotherapy. Patients who were diagnosed to have pathologically proved mUC between 1997 and 2016 and received palliative chemotherapy with platinum based regimen were recruited into our study. Kaplan-Meier curves and Cox regression analysis were constructed for overall survival (OS)...
May 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29748098/multi-institutional-evaluation-of-the-prognostic-significance-of-ezh2-expression-in-high-grade-upper-tract-urothelial-carcinoma
#10
Nirmish Singla, Laura-Maria Krabbe, Ahmet M Aydin, Vandana Panwar, Solomon L Woldu, Yuval Freifeld, Christopher G Wood, Jose A Karam, Alon Z Weizer, Jay D Raman, Mesut Remzi, Nathalie Rioux-Leclercq, Andrea Haitel, Marco Roscigno, Christian Bolenz, Karim Bensalah, Arthur I Sagalowsky, Shahrokh F Shariat, Yair Lotan, Aditya Bagrodia, Payal Kapur, Vitaly Margulis
PURPOSE: Enhancer of zeste homolog 2 is a methyltransferase encoded by the EZH2 gene, whose role in upper tract urothelial carcinoma (UTUC) is poorly understood. We sought to evaluate the prognostic value of EZH2 expression in UTUC. METHODS: We reviewed a multi-institutional cohort of patients who underwent radical nephroureterectomy for high-grade UTUC from 1990 to 2008. Immunohistochemistry for EZH2 was performed on tissue microarrays. Percentage of staining was evaluated, and the discriminative value of EZH2 was tested, with EZH2 positivity defined as>20% staining present...
May 7, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29744601/asymptomatic-recurrence-detection-and-cost-effectiveness-in-urothelial-carcinoma
#11
REVIEW
Hiromichi Iwamura, Shingo Hatakeyama, Makoto Sato, Chikara Ohyama
For the management of muscle-invasive bladder cancer or upper tract urothelial carcinoma, the set guidelines recommend regular surveillance after radical cystectomy or radical nephroureterectomy. However, the prognostic benefit of regular oncological surveillance remains controversial in the absence of prospective studies although several retrospective studies with relatively large sample sizes have demonstrated the association between asymptomatic recurrence and better oncological outcomes. Seven out of eight studies reported that patients diagnosed with symptomatic recurrence showed significantly poorer prognosis in comparison to those diagnosed with asymptomatic recurrence...
May 9, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29742604/right-ureteral-carcinoma-suggested-by-99mtc-dtpa-renography-in-a-patient-with-left-pyelocaliceal-carcinoma
#12
Wei Wang, Leilei Yuan, Ying Kan, Jie Liu, Jigang Yang
Abdominal enhanced CT of a 72-year-old woman demonstrated 1 enhancing lesion in the left kidney, which suggested malignancy. No significant findings were reported in the right kidney and ureter. A Tc-DTPA renography was performed as part of the presurgical evaluation. However, the dynamics of urine elimination by the left kidney was normal, whereas elimination of the urine on the right one delayed, which was unexpected. The patient's CT images were further analyzed. An enhancing lesion in the right ureter was noted by further review, suggesting malignancy, which was subsequently pathologically proven as low-grade papillary urothelial carcinoma...
May 7, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29740903/utility-of-intravoxel-incoherent-motion-mri-derived-parameters-for-prediction-of-aggressiveness-in-urothelial-bladder-carcinoma
#13
Miaomiao Zhang, Yan Chen, Xinying Cong, Xinming Zhao
BACKGROUND: Preoperative accurate judgment of aggressiveness is of great importance to determine treatment and prognosis of bladder cancers. PURPOSE: To evaluate the utility of IVIM-MRI parameters in predicting aggressiveness of bladder urothelial carcinoma. STUDY TYPE: Prospective. POPULATION MODEL: Sixty-seven patients with bladder urothelial cancer. FIELD STRENGTH/SEQUENCE: 3.0 T/T2WI and IVIM-MRI...
May 8, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29733795/muscle-invasive-bladder-and-urethral-cancer-recurrence-after-surgical-management-of-upper-tract-urothelial-carcinoma-a-review-of-305-patients
#14
Mohamed Mohamed Elawdy, Yasser Osman, Diaa Eldin Taha, Samer El-Halwagy
OBJECTIVE: Bladder cancer recurrence after management of upper tract urothelial carcinoma (UTUC) is a common disease. Although the incidence and risk factors for the development of noninvasive bladder tumor have been reported in many series, rare studies have reported on muscle invasive bladder cancer (MIBC) and its urethral recurrence. We aimed to report the incidence, risk factors and survival rate for the development of MIBC and urethral tumors after surgical management of UTUC. MATERIAL AND METHODS: We retrospectively reviewed patients who were surgically treated for UTUC from 1983 to 2013...
May 2018: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29732388/systematic-review-characteristics-and-preclinical-uses-of-bladder-cancer-cell-lines
#15
Tahlita C M Zuiverloon, Florus C de Jong, James C Costello, Dan Theodorescu
Background: Bladder cancer (BC) cell lines are indispensable in basic and preclinical research. Currently, an up-to-date and comprehensive overview of available BC cell lines is not available. Objective: To provide an overview and resources on the origin, pathological and molecular characteristics of commonly used human, murine and canine BC cell lines. Methods: A PubMed search was performed for relevant articles published between 1980 and 2017 according to the following MeSH terms: cell line; cell line, tumor; urinary bladder neoplasms; carcinoma, transitional cell...
April 26, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/29731799/beware-of-bone-marrow-incidental-detection-and-primary-diagnosis-of-solid-tumours-in-bone-marrow-aspiration-and-biopsies-a-study-of-22-cases
#16
Ruchita Tyagi, Aminder Singh, Bhavna Garg, Neena Sood
Background & objective: Introduction: First detection of any solid tumour as metastatic deposits in bone marrow directs clinicians to start searching for the primary tumour. Detection of bone marrow metastasis determines the stage of the malignancy, prognosis, mode of treatment, chemotherapeutic response and follow-up in case of relapse. The aim of the current study was to analyse the clinico-haematological presentation and morphological pattern of infiltration of solid tumours detected first as metastatic deposits on bone marrow examination...
2018: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/29731099/oncologic-outcomes-of-post-kidney-transplantation-superficial-urothelial-carcinoma
#17
G-L Huang, H-L Luo, Y-T Chen, Y-T Cheng
PURPOSE: To analyze the oncologic effect of post-kidney transplantation (KT) immunosuppressive status for end-stage renal disease (ESRD) patients with superficial urothelial carcinoma. METHODS: From 2010 to 2015, there were 106 ESRD patients with superficial urinary bladder urothelial carcinoma (UB-UC) and 68 ESRD patients with superficial upper urinary tract urothelial carcinoma (UT-UC) in a single institution. Oncologic outcomes including bladder cancer recurrences and systemic disease recurrences within 5 years were compared between patients with and without KT...
May 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29725402/high-expression-of-b7-h3-and-cd163-in-cancer-tissues-indicates-malignant-clinicopathological-status-and-poor-prognosis-of-patients-with-urothelial-cell-carcinoma-of-the-bladder
#18
Zhili Xu, Ling Wang, Jianhua Tian, Hongwei Man, Pengfei Li, Baoen Shan
The objective of the present study was to investigate the association of B7-H3 expression and cluster of differentiation (CD)163+ tumor-associated macrophage (TAM) infiltration with clinicopathological parameters in urothelial cell carcinoma of the bladder (UCB), and to investigate their potential conjoint effects on progression of UCB. B7-H3 expression and CD163+ TAM infiltration in tumor specimens from 134 consecutive patients that underwent radical cystectomy for UCB were tested using immunohistochemistry, followed by statistical analysis...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29719336/study-of-proliferating-cell-nuclear-antigen-expression-and-angiogenesis-in-urothelial-neoplasms-correlation-with-tumor-grade-and-stage
#19
Poojan Agarwal, Achin Kumar Sen, Minakshi Bhardwaj, Veronique Dinand, Arvind Ahuja, Rajeev Sood
Background: Urinary bladder carcinoma ranks ninth in worldwide cancer incidence. About 74,000 new cases were diagnosed in 2015 alone and 16,000 persons died of the disease. Since histopathology is considered gold standard for diagnosis, it is prudent to look for potential tumor proliferation and predictive markers in such a prevalent malignancy so as to alert surgical and medical oncologists for timely intervention and provide better patient-tailored therapy. Aims: This study is to analyze the role of potential biomarkers-proliferating cell nuclear antigen (PCNA) and angiogenesis using CD31 in urothelial neoplasms in relation to tumor grade and stage...
April 2018: Urology Annals
https://www.readbyqxmd.com/read/29701416/co-existence-of-abdominal-aortic-aneurysm-with-urologic-neoplasm-which-should-be-treated-first-in-the-endovascular-era
#20
José Oliveiar-Pinto, Nilo Mosquera, José Vidoedo, Sérgio Moreira-Sampaio, José Teixeira
INTRODUCTION: Prevalence of Abdominal Aortic Aneurysm (AAA) with concomitant malignancy rounds 3-13%. Considering only urological neoplasms the prevalence is around 3.6%. Survival at 5 years of bladder carcinoma without extravesical invasion (stage II) rounds 63%. Endovascular Aneurysm Repair (EVAR), due to its minimally invasive profile, is an option for treatment of AAA prior to urological surgery as it does not require laparotomy not conditioning the delay of oncologic surgery. METHODS: Male, 62 years old...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
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