keyword
MENU ▼
Read by QxMD icon Read
search

Urothelial carcinoma pathology

keyword
https://www.readbyqxmd.com/read/27906675/preoperative-serum-pre-albumin-as-an-independent-prognostic-indicator-in-patients-with-localized-upper-tract-urothelial-carcinoma-after-radical-nephroureterectomy
#1
Jiwei Huang, Yanqing Wang, Yichu Yuan, Yong-Hui Chen, Wen Kong, Haige Chen, Jin Zhang, Yiran Huang
PURPOSE: To investigate the prognostic value of preoperative pre-albumin and albumin level in patients with localized upper tract urothelial carcinoma (UTUC) undergoing radical nephroureterectomy. METHODS AND MATERIALS: Between January 2003 and June 2013, we evaluated data on 425 patients with nonmetastatic UTUC (Ta-4N0/+M0) who underwent radical nephroureterectomy at our institution. Low pre-albumin level was defined as <20 mg/dl, while hypoalbuminemia was defined as albumin <35 g/L...
November 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27895794/trousseau-s-syndrome-caused-by-bladder-cancer-producing-granulocyte-colony-stimulating-factor-and-parathyroid-hormone-related-protein-a-case-report
#2
Tomonori Kato, Kenji Yasuda, Hiroaki Iida, Akihiko Watanabe, Yasuyoshi Fujiuchi, Shigeharu Miwa, Johji Imura, Akira Komiya
The present study reports a rare case of bladder cancer that caused Trousseau's syndrome, a malignancy-associated hypercoagulative state leading to venous or arterial thrombosis. A 38-year-old Japanese female patient experienced a sudden onset of visual field defects and lower limb weakness. Cerebral magnetic resonance imaging revealed multi-regional hypointense areas compatible with acute cerebral infarction. Despite the repeated administration of anticoagulant treatment with heparin, the condition could not be adequately controlled and thromboembolic events occasionally recurred...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27895377/frequency-and-predictors-of-recurrence-of-bladder-tumour-on-first-check-cystoscopy-a-tertiary-care-hospital-experience
#3
Muhammad Farhan, Syed Muhammad Nazim, Jibran Ahmed, Muhammad Hammad Ather
OBJECTIVE: To determine the frequency and predictors of non-muscle invasive bladder tumour recurrence on first-check cystoscopy after transurethral resection of bladder tumour. METHODS: This cross-sectional study was conducted at the Aga Khan University Hospital, Karachi, from April to November 2014, and comprised patients with a suspected newly-diagnosed urothelial cancer. Patients with non-muscle invasive disease with complete resection of all visible lesions along with deep biopsy from the tumour base were included...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27887951/a-multi-institutional-comparison-of-clinicopathologic-characteristics-and-oncologic-outcomes-of-upper-tract-urothelial-carcinoma-in-china-and-the-united-states
#4
Nirmish Singla, Dong Fang, Xiaohong Su, Zhengqing Bao, Zhenpeng Cao, Syed M Jafri, Gengyan Xiong, Lei Zhang, Ryan Hutchinson, Arthur Sagalowsky, Yair Lotan, Xuesong Li, Liqun Zhou, Jay D Raman, Vitaly Margulis
PURPOSE: To evaluate differences in clinicopathologic characteristics and oncologic outcomes between upper-tract urothelial carcinoma (UTUC) patients in China and the United States (U.S.). METHODS: Clinicopathologic and oncologic outcomes data of UTUC patients treated surgically at tertiary care medical facilities in the U.S. or China from 1998-2015 were retrospectively compiled. Baseline demographics, comorbidities, and pathologic features were evaluated. Oncologic endpoints including intravesical recurrence and cancer-specific survival (CSS) were obtained following exclusion of patients who received systemic chemotherapy...
November 22, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27879443/skeletal-metastasis-of-canine-urothelial-carcinoma-pathologic-and-computed-tomographic-features
#5
V A Charney, M A Miller, H G Heng, H Y Weng, D W Knapp
Invasive urothelial (transitional cell) carcinoma (UC) is the most common cancer in the canine urinary tract. Prolonged survival of dogs with UC due to better management of the primary tumor and prevention of urethral obstruction might have contributed to an apparent increase in distant metastasis. Metastasis to bone is particularly concerning because the ensuing pain often leads to euthanasia; however, little is known of the frequency, site, or nature of UC skeletal metastasis. In a retrospective analysis, 17 (9%) of 188 canine UC cases had histologically confirmed skeletal metastasis, mainly to the vertebrae...
November 22, 2016: Veterinary Pathology
https://www.readbyqxmd.com/read/27875858/contemporary-rates-of-pathological-features-and-mortality-for-adenocarcinoma-of-the-urinary-bladder-in-the-usa
#6
Emanuele Zaffuto, Stéphanie Gazdovich, Sami-Ramzi Leyh-Bannurah, Hartwig Huland, Firas Abdollah, Shahrokh F Shariat, Mani Menon, Alberto Briganti, Francesco Montorsi, Pierre I Karakiewicz
OBJECTIVES: To examine contemporary rates of pathological features and mortality for adenocarcinoma of the urinary bladder in the USA using population-based data analysis. METHODS: We relied on 10 024 patients with non-metastatic bladder cancer diagnosed between 2004 and 2013 within the Surveillance, Epidemiology and End Results registries. Logistic regression analyses focused on grade and stage. Kaplan-Meier analyses assessed cancer-specific mortality rates in adenocarcinoma and urothelial carcinoma of the bladder...
November 22, 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/27865750/outcomes-following-radical-cystectomy-for-plasmacytoid-urothelial-carcinoma-defining-the-need-for-improved-local-cancer-control
#7
Patrick A Cockerill, John C Cheville, Stephen A Boorjian, Andrew Blackburne, Prabin Thapa, Robert F Tarrell, Igor Frank
OBJECTIVE: To evaluate oncologic outcomes after radical cystectomy (RC) in patients with plasmacytoid urothelial carcinoma (UC), and compared survival to that in patients with pure UC of the bladder. METHODS: We identified 46 patients with plasmacytoid UC and 972 with pure UC who were treated with RC between 1980 and 2009. All pathologic specimens were re-reviewed by a single GU pathologist. Patients were matched 1:2 by age, gender, ECOG performance status, pathological tumor stage and nodal status to patients with pure UC...
November 16, 2016: Urology
https://www.readbyqxmd.com/read/27846934/-ccafu-french-national-guidelines-2016-2018-on-upper-tract-tumors
#8
M Rouprêt, P Colin, E Xylinas, E Compérat, F Dubosq, N Houédé, S Larré, A Masson-Lecomte, Y Neuzillet, G Pignot, P Puech, M Roumiguié, A Méjean
INTRODUCTION: The purpose was to propose an update of the french guidelines from the national committee CCAFU on upper tract urothelial carcinomas (UTUC). METHODS: A systematic Medline search was performed between 2013 and 2016, as regards diagnosis, options of treatment and follow-up of UTUC, to evaluate different references with levels of evidence. RESULTS: The diagnosis of this rare pathology is based on CT-scan acquisition during excretion and ureteroscopy with histological biopsies...
November 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27830374/prognostic-role-of-expression-of-n-cadherin-in-patients-with-upper-tract-urothelial-carcinoma-a-multi-institutional-study
#9
Mohammad Abufaraj, Marco Moschini, Francesco Soria, Kilian Gust, Mehmet Özsoy, Romain Mathieu, Morgan Rouprêt, Vitaly Margulis, Jose A Karam, Christopher G Wood, Alberto Briganti, Karim Bensalah, Andrea Haitel, Shahrokh F Shariat
PURPOSE: To assess the role of N-cadherin as prognostic biomarker in patients with upper tract urothelial carcinoma (UTUC) in a large multi-institutional cohort of patients. PATIENTS AND METHODS: Immunohistochemistry was used to evaluate the status of N-cadherin expression in 678 patients with unilateral sporadic UTUC treated with radical nephroureterectomy. N-cadherin was considered positive if any immunoreactivity with membranous staining was detected. The Kaplan-Meier method was used to estimate recurrence-free survival, overall survival and cancer-specific survival...
November 9, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27818773/transurethral-biopsy-of-the-prostatic-urethra-is-associated-with-final-apical-margin-status-at-radical-cystoprostatectomy
#10
Friedrich-Carl von Rundstedt, Douglas A Mata, Steven Shen, Yi Li, Guilherme Godoy, Seth P Lerner
PURPOSE: Biopsy of the prostatic urethra is an integral part of clinical staging in patients prior to radical cystoprostatectomy (RC) and urinary diversion. We examined whether preoperative transurethral resection (TUR) biopsy was associated with final apical urethral margin status and hypothesized that a negative biopsy could replace intraoperative frozen section for decision making regarding the feasibility of orthotopic neobladder reconstruction. METHODS: TUR biopsy, frozen section, urethrectomy, and final apical urethral margin pathologic data were extracted from the charts of men who had undergone RC at the Houston Methodist Hospital between 1987 and 2013...
November 2016: Journal of Clinical Urology
https://www.readbyqxmd.com/read/27818288/clinical-significance-of-prominent-retraction-clefts-in-invasive-urothelial-carcinoma
#11
Tanmay S Shah, Matthew Kaag, Jay D Raman, Wilson Chan, Truc Tran, Sudhir Kunchala, Lauren Shuman, David J DeGraff, Guoli Chen, Joshua I Warrick
Micropapillary morphology in invasive urothelial carcinoma is an established predictor of aggressive disease. It is unknown, however, if prominent retraction is associated with more aggressive disease in the absence of classic micropapillary morphology. We reviewed a retrospective series of 309 radical cystectomy specimens with clinical follow-up data, and documented the presence or absence of invasive urothelial carcinoma with "prominent retraction clefts," defined as invasive carcinoma with retraction involving the majority of invasive tumor nests in at least one 100X field, but without classic micropapillary morphology...
November 3, 2016: Human Pathology
https://www.readbyqxmd.com/read/27816604/invasive-high-grade-upper-tract-urothelial-carcinoma-in-a-14-year-old-girl
#12
Michael K Lam, Aaron P Bayne, Gregory A Thomas, J Christopher Austin
We present an unusual pediatric case of invasive upper tract urothelial carcinoma with an associated genetic predisposition. A 14 year-old female presented with intermittent right flank pain, and was found to have a poorly functioning hydronephrotic right kidney. Laparoscopic nephrectomy was performed. Pathology demonstrated upper tract urothelial carcinoma, and she subsequently underwent completion ureterectomy. Genetic studies demonstrated a double-hit constitutional deletion of a DNA mismatch repair protein, revealing a rare Lynch syndrome variant known as Constitutional Mismatch Repair Deficiency Syndrome (CMMRD)...
November 2, 2016: Urology
https://www.readbyqxmd.com/read/27816402/external-validation-of-the-pathological-nodal-staging-score-in-upper-tract-urothelial-carcinoma-a-population-based-study
#13
Evanguelos Xylinas, Luis Kluth, Malte Rieken, Morgan Rouprêt, Bashir Al Hussein Al Awamlh, Thomas Clozel, Maxine Sun, Pierre I Karakiewicz, Mithat Gonen, Shahrokh F Shariat
OBJECTIVES: To externally validate our previously developed pathological nodal staging model (pNSS) that allows quantification of the likelihood that a patient with pathologic node-negative status has, indeed, no lymph node metastasis (LNM). PATIENTS AND METHODS: We analyzed data from 2,768 patients treated with radical nephroureterectomy (RNU) and lymph node dissection (LND) using the Surveillance, Epidemiology, and End Results database from 1988 to 2010. We estimated the sensitivity of pathologic nodal staging using a beta-binomial model and developed a new pNSS...
November 2, 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27814469/pathological-downstaging-and-survival-after-induction-chemotherapy-and-radical-cystectomy-for-clinically-node-positive-bladder-cancer-results-of-a-nationwide-population-based-study
#14
Tom J N Hermans, Elisabeth E Fransen van de Putte, Simon Horenblas, Richard P Meijer, Joost L Boormans, Katja K H Aben, Michiel S van der Heijden, Ronald de Wit, Laurens V Beerepoot, Rob H A Verhoeven, Bas W G van Rhijn
BACKGROUND: Induction chemotherapy (IC) for clinically node-positive bladder cancer is applied without clinical evidence of improved outcome. Our objective was to compare complete pathological downstaging (pCD) and overall survival (OS) for IC versus upfront radical cystectomy (RC) in cT1-4aN1-3M0 urothelial carcinoma (UC). METHODS: This population-based study included 659 cN+ patients treated with RC between 1995 and 2013. IC was applied in 212 (32%) patients...
October 27, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27785429/predictive-models-and-prognostic-factors-for-upper-tract-urothelial-carcinoma-a-comprehensive-review-of-the-literature
#15
REVIEW
Aurélie Mbeutcha, Romain Mathieu, Morgan Rouprêt, Kilian M Gust, Alberto Briganti, Pierre I Karakiewicz, Shahrokh F Shariat
In the context of customized patient care for upper tract urothelial carcinoma (UTUC), decision-making could be facilitated by risk assessment and prediction tools. The aim of this study was to provide a critical overview of existing predictive models and to review emerging promising prognostic factors for UTUC. A literature search of articles published in English from January 2000 to June 2016 was performed using PubMed. Studies on risk group stratification models and predictive tools in UTUC were selected, together with studies on predictive factors and biomarkers associated with advanced-stage UTUC and oncological outcomes after surgery...
October 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/27785428/risk-stratification-for-kidney-sparing-procedure-in-upper-tract-urothelial-carcinoma
#16
REVIEW
Zine-Eddine Khene, Romain Mathieu, Solène-Florence Kammerer-Jacquet, Thomas Seisen, Morgan Roupret, Shahrokh F Shariat, Benoit Peyronnet, Karim Bensalah
Risk stratification for kidney sparing procedures (KSP) to treat upper tract urothelial carcinoma (UTUC) is a major issue. A non-systematic Medline/PubMed literature search was performed using the terms "upper tract urothelial carcinoma" with different combinations of keywords to review the current knowledge on this topic. Original articles, reviews and editorials in English language were selected based on their clinical relevance. Available techniques for KSP include segmental ureterectomy and endoscopic resection through a percutaneous or flexible ureteroscopic access...
October 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/27785420/why-are-upper-tract-urothelial-carcinoma-two-different-diseases
#17
REVIEW
Tibor Szarvas, Orsolya Módos, András Horváth, Péter Nyirády
In the last few years growing evidence highlighted the differences between upper tract urothelial carcinoma (UTUC) and urothelial bladder carcinoma (UBC) which cannot be explained solely by their different anatomical location. The aim of this review was to summarize current progress in UTUC research and to underline the differences and similarities between UTUC and UBC by focusing on epidemiology, etiology, staging and risk factors as well as on surgical and medical management. UBC and UTUC sharing common risk factors such as smoking and aromatic amines, while aristolochic acid exposure or familiar Lynch syndrome are rather specific for UTUC...
October 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/27772934/urothelial-carcinoma-of-bladder-in-department-of-pathology-dr-soetomo-hospital-surabaya-a-descriptive-retrospective-study
#18
Anny Setijo Rahaju, Alphania Rahniayu
No abstract text is available yet for this article.
February 2016: Pathology
https://www.readbyqxmd.com/read/27769917/challenges-in-the-diagnosis-of-urothelial-carcinoma-variants-can-emerging-molecular-data-complement-pathology-review
#19
James P Solomon, Brett M Lowenthal, A Karim Kader, J Kellogg Parsons, Thomas W Flaig, Arlene O Siefker-Radtke, Lars Dyrskjøt, Donna E Hansel
Urothelial carcinoma can exhibit a wide variety of histopathological phenotypes or variant morphologies, classifications of which have recently been revised in the 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs. Many of these variants not only present diagnostic challenges, but also have clinical implications that affect patient prognosis and treatment strategies. This review will discuss these variant morphologies and their relationship to current understanding of the underlying biology of urothelial carcinoma and molecular classification paradigms...
October 18, 2016: Urology
https://www.readbyqxmd.com/read/27756245/a-diagnostic-marker-for-superficial-urothelial-bladder-carcinoma-lack-of-nuclear-atbf1-zfhx3-by-immunohistochemistry-suggests-malignant-progression
#20
Makoto Kawaguchi, Noboru Hara, Vladimir Bilim, Hiroshi Koike, Mituko Suzuki, Tae-Sun Kim, Nan Gao, Yu Dong, Sheng Zhang, Yuji Fujinawa, Osamu Yamamoto, Hiromi Ito, Yoshihiko Tomita, Yuchi Naruse, Akira Sakamaki, Yoko Ishii, Koichi Tsuneyama, Masaaki Inoue, Johbu Itoh, Masanori Yasuda, Nobuo Sakata, Cha-Gyun Jung, Satoshi Kanazawa, Hiroyasu Akatsu, Hiroshi Minato, Takayuki Nojima, Kiyofumi Asai, Yutaka Miura
BACKGROUND: Pathological stage and grade have limited ability to predict the outcomes of superficial urothelial bladder carcinoma at initial transurethral resection (TUR). AT-motif binding factor 1 (ATBF1) is a tumor suppressive transcription factor that is normally localized to the nucleus but has been detected in the cytoplasm in several cancers. Here, we examined the diagnostic value of the intracellular localization of ATBF1 as a marker for the identification of high risk urothelial bladder carcinoma...
October 18, 2016: BMC Cancer
keyword
keyword
95538
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"