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Testicular germ cell tumor pathology

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https://www.readbyqxmd.com/read/28816282/-long-term-follow-up-experience-of-comprehensive-treatment-of-testicular-mixed-germ-cell-tumors
#1
J F Ye, B Wang, L L Ma, L Zhao, G L Wang, K Hong
OBJECTIVE: Testicular mixed germ cell tumor is mixed with embryonal carcinoma, choriocarcinoma, yolk sac tumor, teratoma, seminoma and other two or more components of the testicular tumor, the clinical is relatively rare and high degree of malignancy, this article will summarize its clinical features and optimize its treatment. METHODS: A retrospective analysis of the clinical data of 22 patients with testicular tumor mixed germ cell in Peking University Third Hospital from May 1994 to November 2016 was conducted using a combination of statistical analysis and discussion of the relevant literature...
August 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28719463/do-nonseminomatous-germ-cell-tumors-of-the-testis-with-lymphovascular-invasion-of-the-spermatic-cord-merit-staging-as-pt3
#2
Jennifer Gordetsky, Joseph Sanfrancesco, Jonathan I Epstein, Karen Trevino, Huiping Xu, Adeboye Osunkoya, Guang Q Xiao, Chia-Sui Kao, Pamela Unger, Neda Hashemi-Sadraei, Constantine Albany, Julie M Jorns, David Y Lu, Andres Matoso, Soroush Rais-Bahrami, Lauren E Schwartz, Thomas M Ulbright, Muhammad T Idrees
The staging of testicular nonseminomatous germ cell tumors (NSGCTs) with lymphovascular invasion (LVI) of the spermatic cord in the absence of cord parenchymal involvement remains controversial. Our previous study showed that tumors with spermatic cord LVI present at a higher clinical stage than tumors with LVI confined to the testis (pT2). We compared NSGCTs with LVI of the spermatic cord without direct involvement of the spermatic cord soft tissues to pT3 tumors to help clarify the appropriate staging of this histologic finding...
July 17, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28715257/association-between-testicular-microlithiasis-and-testicular-neoplasia-large-multicenter-study-in-a-pediatric-population
#3
Andrew T Trout, Jeanne Chow, Erin R McNamara, Kassa Darge, Raul Ramirez Grueso, Marthe Munden, Sarah M Rothan, Oscar M Navarro, Marta Tijerín Bueno, Kevin E Bove, Kudakwashe R Chikwava, Amer Heider, M John Hicks, Gino R Somers, Bin Zhang, Jonathan R Dillman
Purpose To retrospectively define the strength of association between testicular microlithiasis and testicular neoplasia in a large geographically diverse pediatric population. Materials and Methods Retrospective review of scrotal ultrasonographic (US) examination reports and pathology specimens obtained between January 2000 and May 2014 at six academic pediatric hospitals in North America was performed. Reported cases were reviewed to confirm microlithiasis. Radiology and pathology data bases were searched for pathology-proven testicular tumors (benign or malignant germ cell or stromal tumors)...
July 17, 2017: Radiology
https://www.readbyqxmd.com/read/28676275/testicular-adrenal-rest-tumor-tart-in-congenital-adrenal-hyperplasia
#4
Hatice Ozisik, Banu Sarer Yurekli, Ilgin Yildirim Simsir, Ilker Altun, Utku Soyaltin, Ezgi Guler, Huseyin Onay, Banu Sarsik, Fusun Saygili
Congenital adrenal hyperplasia is one of the most common autosomal recessive genetic disorders. Testicular adrenal tumors are significant complications of congenital adrenal hyperplasia. We would like to present two patients of testicular adrenal rest tumors. Patient 1 24 year-old male, he was diagnosed with congenital adrenal hyperplasia at the age of 8 due to precocious puberty. He received hydro-cortisone treatment until the age of 18. Testicular mass had been detected and right radical orchiectomy had been applied 6 months ago and reported as testicular adrenal rest tumor...
July 1, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/28658171/gonadal-germ-cell-tumors-in-children-a-retrospective-review-of-a-10-year-single-center-experience
#5
Xiaokun Lin, Dazhou Wu, Na Zheng, Qiongzhang Xia, Yijiang Han
BACKGROUND: The true incidence of gonadal germ cell tumors (GCTs) in children is unknown. Few studies have been published concerning about pediatric gonadal GCTs. The aim of this study is to review and analyze clinical data on the diagnosis and management of gonadal GCTs in children. METHODS: Between 2005 and 2015, 127 pediatric patients (<14 years old) with gonadal GCTs admitted to our institute were reviewed. Clinical features, imaging and laboratory studies, surgical approaches, as well as pathological diagnoses were recorded...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28647396/testicular-cancer-the-usage-of-central-review-for-pathology-diagnosis-of-orchiectomy-specimens
#6
Saul E Harari, Daniel J Sassoon, David S Priemer, Joseph M Jacob, John N Eble, Anna Caliò, David J Grignon, Mohammed Idrees, Costantine Albany, Timothy A Masterson, Nasser H Hanna, Richard S Foster, Thomas M Ulbright, Lawrence H Einhorn, Liang Cheng
BACKGROUND: Radical orchiectomy specimens present a unique set of challenges for pathology assessment owing to their rarity and complexity. This study compares second opinion pathology reports generated at a single, large academic institution to primary reports from outside hospitals. METHODS: A database search was conducted for orchiectomy cases that were sent to our institution for management of testicular cancer from 2014 to 2015. Cases sent for consultation without a finalized diagnosis from the outside hospitals were excluded...
June 21, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28631119/-expression-of-cancer-testis-ct-antigens-in-pediatric-and-adolescent-melanomas
#7
REVIEW
N Behrendt, T Schultewolter, K Busam, D Frosina, G Spagnoli, A Jungbluth
BACKGROUND: One of the main problems in the diagnostics of pediatric melanomas is the differentiation from benign dermal lesions typical for this age group, such as Spitz nevus. The biological behavior of pediatric melanomas differs considerably from that of melanomas in adults. MATERIAL AND METHODS: Cancer testis (CT) antigens are named after their typical expression pattern since they are present in various types of malignant tumors but in normal adult tissues are solely expressed in testicular germ cells...
July 2017: Der Pathologe
https://www.readbyqxmd.com/read/28592902/ggnbp2-is-necessary-for-testis-morphology-and-sperm-development
#8
Anqi Chen, Jixi Li, Lesheng Song, Chaoneng Ji, Marion Böing, Jinzhong Chen, Beate Brand-Saberi
Gametogenetin Binding Protein 2 (GGNBP2) was identified as a tumor suppressor and verified as such by several studies. GGNBP2 has also been reported to be essential for pregnancy maintenance via regulation of trophoblast stem cells. Gametogenetin (GGN) is a testicular germ cell-specific gene expressed in adult testes. As a potential GGN1-interacting protein, the role of GGNBP2 in spermatogenesis has not yet been clarified. We generated heterozygous GGNBP2 knockout mice and bred them by intercrossing. We found that among the offspring, homozygous GGNBP2 knockout (KO) mice were present in severely reduced numbers...
June 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28574809/testicular-seminoma-and-its-mimics-from-the-radiologic-pathology-archives
#9
Jamie Marko, Darcy J Wolfman, Alex L Aubin, Isabell A Sesterhenn
Testicular seminoma is the most common malignant tumor of the testis. It classically manifests as a painless mass. Radiologic evaluation with high-frequency ultrasonography (US) is critical for diagnosis. Seminomas are usually homogeneously hypoechoic masses at US. In challenging cases, magnetic resonance (MR) imaging may help confirm that a mass is intratesticular and provide data for local staging. Computed tomography (CT) provides valuable information for staging, including the presence and size of retroperitoneal lymph nodes...
July 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28569117/testicular-ultrasensitive-doppler-preliminary-experience-a-feasibility-study
#10
Laurence Rocher, Jean-Luc Gennisson, Sophie Ferlicot, Aline Criton, Laurence Albiges, Vincent Izard, Marie France Bellin, Jean-Michel Correas
Background Ultrasensitive Doppler is a novel non-invasive ultrasound (US) Doppler technique that improves sensitivity and resolution for the detection of slow flow. Purpose To investigate the feasibility of ultrasensitive Doppler (USD) for testicular disease diagnosis, using both qualitative and quantitative results. Material and Methods This prospective study was conducted in 160 successive men referred for scrotal US including B-mode and conventional Color-Doppler. A new USD sequence and algorithm dedicated to academic research were implemented into the US system...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28467339/the-primitive-extratesticular-seminoma-diagnosis-of-a-rare-pathology
#11
Luca Saba
 Background: The Primitive Extratesticular Seminoma is a very rare condition and represents 3% of germ cell tumors; it is an indeterminate origin disease, whose diagnosis is often complicated by a nonspecific and highly variable clinical finding. CASE PRESENTATION: A caucasian 55 years old male, non-smoker, arrived to our centre with cough, severe respiratory distress and dysphagia, in a context of the superior vena cava syndrome. A Computed Tomography was performed, which shows the presence of a mediastinal anterior mass with aorto-pulmonary window and left paracardiac invasion...
April 28, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/28440090/spermatocytic-tumor-with-sarcoma-a-rare-testicular-neoplasm
#12
Ashley E Stueck, John E Grantmyre, Lori A Wood, Cheng Wang, Jennifer Merrimen
Spermatocytic tumor, formerly known as spermatocytic seminoma, is an uncommon testicular neoplasm which is a distinct clinicopathologic entity from classic seminoma. These tumors are not associated with germ cell neoplasia in situ, other germ cell tumors, or isochromosome 12p. Although typically, these tumors have an excellent prognosis occasional cases are associated with sarcoma and have a very poor prognosis. We present a case of spermatocytic tumor with sarcoma showing a chondrosarcomatous component, discuss the pathologic findings and differential diagnosis and provide follow-up information...
April 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28429716/polyembryoma-of-the-testis-a-report-of-two-cases-dominant-within-mixed-germ-cell-tumors-and-review-of-gonadal-polyembryomas
#13
Jennifer N Stall, Robert H Young
Two testicular mixed germ cell tumors, from men of 21 and 41 years, in which polyembryoma predominated are described. A literature review uncovered an additional five testicular and nine ovarian cases. One tumor occurred in a 60-year-old man, but all others occurred within the typical age range of gonadal germ cell tumors. One male presented with gynecomastia and one female with sexual precocity, but all otherwise had standard clinical manifestations. These tumors are typically large with non-specific gross features, but a few have a prominent hemorrhagic appearance...
July 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28426398/k-ras-and-n-ras-mutations-in-testicular-germ-cell-tumors
#14
Bekir Muhammet Hacioglu, Hilmi Kodaz, Bulent Erdogan, Ahmet Cinkaya, Ebru Tastekin, Ilhan Hacibekiroglu, Esma Turkmen, Osman Kostek, Ezgi Genc, Sernaz Uzunoglu, Irfan Cicin
Testicular cancer is a relatively rare tumor type, accounting for approximately 1% of all cancers in men. However, among men aged between 15 and 40 years, testicular cancer is the most commonly diagnosed malignancy. Testicular germ cell tumors (TGCTs) are classified as seminoma and non-seminoma. The RAS oncogene controls several cellular functions, including cell proliferation, apoptosis, migration, and differentiation. Thus, RAS signaling is important for normal germ cell development. Mutations of the Kirsten RAS (K-RAS) gene are present in over 20% of all cancers...
May 20, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28414684/who-shot-the-cannonballs-extensive-lung-metastases-in-a-39-year-old-man
#15
D Sommerhalder, J Blondin
CASE: A 39 year-old man presented to the emergency department complaining of a cough of 2 months in duration. He also complained of weight loss of 20 pounds in two months and night sweats over the same period. An x-ray of the chest was performed and revealed innumerable lung nodules and masses. Computed tomography of the chest and abdomen were subsequently performed which confirmed the masses, but imaging did not reveal an obvious primary source. A testicular exam was performed but no obvious abnormalities were noted...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28368923/reporting-and-staging-of-testicular-germ-cell-tumors-the-international-society-of-urological-pathology-isup-testicular-cancer-consultation-conference-recommendations
#16
Clare Verrill, Asli Yilmaz, John R Srigley, Mahul B Amin, Eva Compérat, Lars Egevad, Thomas M Ulbright, Satish K Tickoo, Daniel M Berney, Jonathan I Epstein
The International Society of Urological Pathology held a conference devoted to issues in testicular and penile pathology in Boston in March 2015, which included a presentation and discussion led by the testis microscopic features working group. This conference focused on controversies related to staging and reporting of testicular tumors and was preceded by an online survey of the International Society of Urological Pathology members. The survey results were used to initiate discussions, but decisions were made by expert consensus rather than voting...
June 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28285637/erratum-to-testicular-germ-cell-tumors-tgcts-in-neonates-and-infants-seminars-in-diagnostic-pathology-33-2016-410-418
#17
Juan Carlos Manivel
No abstract text is available yet for this article.
January 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/28262537/robot-assisted-retroperitoneal-lymph-node-dissection-ra-rplnd-in-the-adolescent-population
#18
A P Glaser, D K Bowen, B W Lindgren, J J Meeks
BACKGROUND: Robot-assisted retroperitoneal lymph node dissection (RA-RPLND) has built on success and techniques of laparoscopic RPLND, with the added benefits of robotic technology. This paper demonstrates use of the da Vinci Xi(®) system for RA-RPLND in two adolescent patients. METHODS: Case #1: A 17-year-old male presented with a left testicular mass and elevated alpha-fetoprotein (AFP) and human chorionic gonadotropin (HCG). Pathology revealed a mixed non-seminomatous germ cell tumor (60% embryonal, 35% yolk sac, 5% choriocarcinoma, + lymphovascular invasion)...
February 17, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28192608/testis-sparing-surgery-for-treatment-of-small-testicular-lesions-is-it-feasible-even-in-germ-cell-tumors
#19
Nebojsa Bojanic, Uros Bumbasirevic, Gordana Bojanic, Ivan Vukovic, Bogomir Milojevic, Tatjana Pekmezovic
BACKGROUND AND OBJECTIVES: To evaluate the results of testis-sparing surgery (TSS) in patients, with small testicular lesions and a normal contralateral testicle. METHODS: In all, 28 patients were treated with TSS for small testicular lesions and a normal contralateral testicle. TSS was considered in patients with testicular lesions smaller than 2 cm and no evidence of metastatic disease. RESULTS: The mean age of patients was 35.3 ± 7...
March 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28124545/robot-assisted-laparoscopic-retroperitoneal-lymph-node-dissection-in-testicular-tumor
#20
Fabio C M Torricelli, Denis Jardim, Giuliano B Guglielmetti, Vipul Patel, Rafael F Coelho
INTRODUCTION AND OBJECTIVE: Retroperitoneal lymph node dissection (RPLND) is indicated for patients with non-seminomatous germ cell tumor (NSGCT) with residual disease after chemotherapy. Although the gold standard approach is still the open surgery, few cases of robot-assisted laparoscopic RPLND have been described. Herein, we aim to present the surgical technique for robot-assisted laparoscopic RPLND. PATIENT AND METHOD: A 30 year-old asymptomatic man presented with left testicular swelling for 2 months...
January 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
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