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Testicular germ cell tumor pathology

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https://www.readbyqxmd.com/read/28097877/the-epigenetics-of-testicular-germ-cell-tumors-looking-for-novel-disease-biomarkers
#1
Ana Laura Costa, João Lobo, Carmen Jerónimo, Rui Henrique
Testicular germ cell tumors (TGCT) are a group of heterogeneous, biologically diverse and clinically challenging neoplasms. Despite the relatively low incidence and mortality rates, a subgroup of patients with disseminated disease relapse after conventional therapy and have a dismal prognosis. Moreover, TGCT afflict mostly young men and have therapeutic peculiarities, with some patients showing resistance to cisplatin-based treatments and others being troubled by irreversible side effects, such as infertility...
January 18, 2017: Epigenomics
https://www.readbyqxmd.com/read/28066838/neuroendocrine-carcinoma-of-the-ovotestis-a-case-report-and-review-of-literatures
#2
Tahereh Ashrafganjoei, Ainaz Sourati, Mahdiss Mohamadianamiri
BACKGROUND: Neuroendocine carcinoma of the gynecologic tract is rare and poses a significant clinical challenge because of tumor heterogeneity and lack of standardized guidelines for treatment. Ovotestis refers to the histology of a gonad that contains both ovarian follicles and testicular tubular elements. Ovotesticular disorder of sexual development occurs in fewer than 10% of all disorders of sexual development. Gonadal tumors with malignant potential occur in 2.6% of all cases of ovotesticular disorder of sexual development...
December 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/28002522/primary-retroperitoneal-seminoma-embryology-histopathology-and-treatment-particularities
#3
Constantin Virgil Gîngu, Mihaela Mihai, Cătălin Baston, Mugurel Alexandru Crăsneanu, Alexandru Vladimir Dick, Vlad Olaru, Ioanel Sinescu
INTRODUCTION: Retroperitoneal seminoma is a very rare form of cancer, with embryological origin represented by primordial germ cells from the urogenital ridges left behind during the fetal development. Extragenital germ cell tumors can also occur in the mediastinum or the pineal gland. The aim of this paper is to outline the particularities and draw embryological, histopatological and treatment conclusions regarding extragonadal germ cell tumors. PATIENT AND METHODS: A 43-year-old patient without any additional pathology was admitted for anemia of unknown etiology...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27822117/the-danish-testicular-cancer-database
#4
REVIEW
Gedske Daugaard, Maria Gry Gundgaard Kier, Mikkel Bandak, Mette Saksø Mortensen, Heidi Larsson, Mette Søgaard, Birgitte Groenkaer Toft, Birte Engvad, Mads Agerbæk, Niels Vilstrup Holm, Jakob Lauritsen
AIM: The nationwide Danish Testicular Cancer database consists of a retrospective research database (DaTeCa database) and a prospective clinical database (Danish Multidisciplinary Cancer Group [DMCG] DaTeCa database). The aim is to improve the quality of care for patients with testicular cancer (TC) in Denmark, that is, by identifying risk factors for relapse, toxicity related to treatment, and focusing on late effects. STUDY POPULATION: All Danish male patients with a histologically verified germ cell cancer diagnosis in the Danish Pathology Registry are included in the DaTeCa databases...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27796764/more-cases-of-benign-testicular-teratomas-are-detected-in-adults-than-in-children-a-clinicopathological-study-of-543-testicular-germ-cell-tumor-cases
#5
Semjén David, Farkas András, Kalman Endre, Kaszas Balint, Kovács Árpad, Pusztai Csaba, Szuhai Karoly, Tornóczky Tamás
Benign testicular teratomas are always thought to be pediatric neoplasms and previously all the teratoid tumors in the adult testis regarded as malignant. Recently, three publications reported benign testicular teratomas in adulthood and the latest WHO classification refers them as "prepubertal type of teratomas" which rarely appear in adulthood. These neoplasms behave benign and seemingly analogous independently whether they appear in pre- or postpubertal patients. The aim of our study was to investigate the frequency of benign testicular teratomas both in children and adults...
October 28, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27785439/malignancy-in-disorders-of-sex-development
#6
REVIEW
Martin Kathrins, Thomas F Kolon
Disorders of sex development (DSD) represent a spectrum of conditions in which chromosomal, gonadal, or anatomic sex are atypical and affect 1 in 4,500-5,000 live births. The diagnosis of DSD raises concerns of tumor risk and treatment as well as future fertility preservation. We review the current understanding of the types of gonadal tumors that arise in DSD patients as well as possible markers and treatment. The goal is to inform the members of the DSD team (urologist, endocrinologist, geneticist, psychologist) of the latest findings regarding malignancy in DSD...
October 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/27778488/robot-assisted-laparoscopic-retroperitoneal-lymph-node-dissection-in-testicular-tumor
#7
Fabio C M Torricelli, Denis Jardim, Giuliano B Guglielmetti, Vipul Patel, Rafael F Coelho
INTRODUCTION AND OBJECTIVE: Retroperitoneal lymph node dissection (RPLND) is indicated for patients with non-seminoma¬tous germ cell tumor (NSGCT) with residual disease after chemotherapy. Although the gold standard approach is still the open surgery, few cases of robot-assisted laparoscopic RPLND have been described. Herein, we aim to present the surgical technique for robot-assisted laparoscopic RPLND. PATIENT AND METHOD: A 30 year-old asymptomatic man presented with left testicular swelling for 2 months...
October 25, 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27733750/can-we-predict-chemotherapy-response-in-patients-with-metastatic-testicular-cancer-role-of-thrombocytosis-as-a-novel-marker
#8
Mehmet I Gokce, Murat Mermerkaya, Evren Süer, Faraj Afandiyev, Sümer Baltaci
BACKGROUND: Primary treatment of choice for advanced germ cell tumors is 3 to 4 cycles of combination PEB chemotherapy. Although most patients treated for advanced germ cell tumors (GCT) will be cured, approximately 30% will fail to achieve a durable complete response (CR). Thrombocytosis has been found to be related with significantly shorter survival in many cancers. However, its role in testicular cancer patients has not been studied previously. The objective of this study was to investigate the relationship between thrombocytosis and chemotherapy response in patients with metastatic testicular cancer...
October 12, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27608010/regulation-of-translocator-protein-18-kda-tspo-expression-in-rat-and-human-male-germ-cells
#9
Gurpreet Manku, Martine Culty
Translocator protein 18 kDa (TSPO) is a high affinity cholesterol- and drug-binding protein highly expressed in steroidogenic cells, such as Leydig cells, where it plays a role in cholesterol mitochondrial transport. We have previously shown that TSPO is expressed in postnatal day 3 rat gonocytes, precursors of spermatogonial stem cells. Gonocytes undergo regulated phases of proliferation and migration, followed by retinoic acid (RA)-induced differentiation. Understanding these processes is important since their disruption may lead to the formation of carcinoma in situ, a precursor of testicular germ cell tumors (TGCTs)...
September 6, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27569358/-a-case-of-metastatic-seminomatous-testicular-tumor-with-complicated-diagnosis-by-fdg-pet
#10
Akihito Hashizume, Nobuhiko Mizuno, Masaki Kawai, Takeshi Kishida
18F-fluorodeoxy glucose positron emission tomography (FDG-PET) for evaluation of the post chemotherapy residual tumor of the seminomatous testicular germ cell tumor is recommended by several guidelines. We report a case whose residual tumor was evaluated by FDG PET but the results were difficult to interpret. A 41-year-old male with left seminomatous germ cell tumor of the testis and 60 mm retroperitoneal lymph node (RPLN) metastasis was referred to our hospital. The International Germ Cell Consensus Classification (IGCCC) was good prognosis...
July 2016: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/27543603/impaired-planar-germ-cell-division-in-the-testis-caused-by-dissociation-of-rhamm-from-the-spindle-results-in-hypofertility-and-seminoma
#11
Huaibiao Li, Lucien Frappart, Jurgen Moll, Anne Winkler, Torsten Kroll, Jana Hamann, Iris Kufferath, Marco Groth, Stefan Taudien, Moritz Schütte, Marie-Laure Yaspo, Heike Heuer, Bodo M H Lange, Matthias Platzer, Kurt Zatloukal, Peter Herrlich, Aspasia Ploubidou
Hypofertility is a risk factor for the development of testicular germ cell tumors (TGCTs), but the initiating event linking these pathologies is unknown. We hypothesized that excessive planar division of undifferentiated germ cells promotes their self-renewal and TGCT development. However, our results obtained from mouse models and seminoma patients demonstrated the opposite. Defective planar divisions of undifferentiated germ cells caused their premature exit from the seminiferous tubule niche, resulting in germ cell depletion, hypofertility, intratubular germ cell neoplasia and seminoma development...
August 19, 2016: Cancer Research
https://www.readbyqxmd.com/read/27416669/-treatments-of-stage-is-testicular-mixed-germ-cell-tumors-a-report-of-3-cases
#12
Jiang-ze Wang, Shan-shan Hu, Lin-mei Zhang, Teng-feng Chen
OBJECTIVE: To investigate different treatment methods for stage-Is testicular mixed germ cell tumors (TMGCTs). METHODS: We retrospectively analyzed the clinical data about 3'cases of stage-Is TMGCTs (aged 26-39 years) treated in the 175th Hospital of PLA, reviewed relevant literature, and explored the clinical characteristics of TMGCTs. RESULTS: Of the 3 patients, 1 was treated by radical orchiectomy, 1 by radical orchiectomy + retroperitoneal lymph node dissection + BEP chemotherapy scheme, and the other by radical orchiectomy + radiotherapy...
May 2016: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/27274891/clinical-and-histopathological-results-of-the-adult-patients-with-unilateral-cryptorchidism
#13
Ferhat Ateş, Hasan Soydan, Sezgin Okçelik, Abdullah Çırakoğlu, İsmail Yılmaz, Ercan Malkoç, Kenan Karademir
OBJECTIVE: To evaluate the clinical and histopathological results of adult unilateral cryptorchidism patients. MATERIAL AND METHODS: Data from adult unilateral cryptorchidism patients that underwent orchiectomy in our clinic between between January 2004 and March 2013 were retrospectively evaluated. Patients were divided into three groups as intra-abdominal, inguinal canal and superficial inguinal region according to the location of the undescended testes. Patients were also grouped according to their testicular volume (<4 cc, 4...
June 2016: Turkish Journal of Urology
https://www.readbyqxmd.com/read/27257466/testicular-hemangioma-mimicking-a-malignant-neoplasm
#14
Rafik Ben Abda, Daniel Bess, Neris Nieves-Robbins
A 34-year-old man who presented with right scrotal pain, and who on subsequent ultrasound examination, was found to have an intratesticular hypoechoic mass. Based on the ultrasound appearance of this mass, a malignant germ cell tumor was thought to be the most likely diagnosis. Preoperative serum tumor markers, including lactate dehydrogenase, alpha-1-fetoprotein, and beta-human chorionic gonadotropin, were negative. Computed tomography imaging of the chest, the abdomen, and the pelvis revealed no evidence of metastasis...
June 2016: Radiology case reports
https://www.readbyqxmd.com/read/27235751/pelvic-lymph-node-dissection-in-patients-treated-for-testis-cancer-the-memorial-sloan-kettering-cancer-center-experience
#15
Shaheen R Alanee, Brett S Carver, Darren R Feldman, Robert J Motzer, George J Bosl, Joel Sheinfeld
OBJECTIVE: To describe the pathologic findings and clinical outcome data for patients undergoing pelvic lymph node dissection (PLND) in the course of management of testicular germ cell tumors at Memorial Sloan Kettering Cancer Center (MSKCC). PATIENTS AND METHODS: Following institutional review board approval, data on 2186 patients who underwent retroperitoneal lymph node dissection (RPLND) at MSKCC between 1989 and 2011 were retrospectively reviewed. Of these 2186 patients, we analyzed data for 44 patients (2%) who underwent PLND at the time of RPLND...
September 2016: Urology
https://www.readbyqxmd.com/read/27234998/safety-and-early-oncologic-effectiveness-of-primary-robotic-retroperitoneal-lymph-node-dissection-for-nonseminomatous-germ-cell-testicular-cancer
#16
Shane M Pearce, Shay Golan, Michael A Gorin, Amy N Luckenbaugh, Stephen B Williams, John F Ward, Jeffrey S Montgomery, Khaled S Hafez, Alon Z Weizer, Phillip M Pierorazio, Mohamad E Allaf, Scott E Eggener
BACKGROUND: Primary robot-assisted retroperitoneal lymph node dissection (R-RPLND) has been studied as an alternative to open RPLND in single-institution series for patients with low-stage nonseminomatous germ cell tumors (NSGCT). OBJECTIVE: To evaluate a multicenter series of primary R-RPLND for low-stage NSGCT. DESIGN, SETTING, AND PARTICIPANTS: Between 2011 and 2015, 47 patients underwent primary R-RPLND at four centers for Clinical Stage (CS) I-IIA NSGCT...
May 24, 2016: European Urology
https://www.readbyqxmd.com/read/27195317/the-histologic-features-of-intratubular-germ-cell-neoplasia-and-its-correlation-with-tumor-behavior
#17
Abbas Basiri, Saeed Movahhed, Mahmood Parvin, Maziar Salimi, Gholam Hossein Rezaeetalab
PURPOSE: To assess the prevalence of intratubular germ cell neoplasia (ITGCN) in patients with concurrent testis tumor and its correlation with histologic features and serum tumor markers. MATERIALS AND METHODS: From 2003 to 2015, 179 patients underwent radical orchiectomy due to testicular mass. Tissue specimens were evaluated by an expert uro-pathologist using immunohistochemistry (IHC) staining, in addition to light microscopy, to identify presence of ITGCN. Patients' demographic characteristics, histologic subtypes, pathologic stage of tumor and serum tumor markers were gathered and analyzed...
May 2016: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/27182465/brain-metastases-as-presenting-feature-in-burned-out-testicular-germ-cell-tumor
#18
Kate Johnson, Bryan Brunet
Testicular germ cell tumors (TGCTs) are the most common malignancy in males aged 20 to 39, and the incidence is increasing. TGCTs have a tendency to grow rapidly with a high risk of metastatic spread. TGCTs generally present with a palpable testicular mass, yet may present less commonly with symptoms arising from metastatic disease.  A 24-year-old otherwise healthy male presented with progressive headaches. Initial imaging reported a single mass in the right frontal lobe. Complete surgical resection revealed suspicion for metastatic poorly differentiated carcinoma with an inconclusive immunohistochemical profile...
2016: Curēus
https://www.readbyqxmd.com/read/27150447/nonpalpable-testicular-pure-seminoma-with-elevated-serum-alpha-fetoprotein-presenting-with-retroperitoneal-metastasis-a-case-report
#19
Shoichiro Iwatsuki, Taku Naiki, Noriyasu Kawai, Toshiki Etani, Keitaro Iida, Ryosuke Ando, Takashi Nagai, Atsushi Okada, Keiichi Tozawa, Yosuke Sugiyama, Takahiro Yasui
BACKGROUND: Patients with a primary pure seminoma in the testis who have elevated serum alpha-fetoprotein are rare and should be treated as patients with nonseminomatous germ cell tumors. However, nonpalpable testicular tumors in this condition have never been reported. We describe a case of nonpalpable pure testicular seminoma with elevated serum alpha-fetoprotein presenting retroperitoneal metastasis. CASE PRESENTATION: A 29-year-old Asian man was referred to our hospital with right flank pain...
May 5, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27124916/do-histopathologic-variables-affect-the-reporting-of-lymphovascular-invasion-in-testicular-germ-cell-tumors
#20
Bryce L French, Debra L Zynger
OBJECTIVES: Identification of lymphovascular invasion (LVI) in testicular germ cell tumors (GCTs) is a challenging yet important aspect of cancer staging that can alter therapeutic management. Our study aimed to identify pathologic features that affect the reporting of LVI. METHODS: Pathology report and slide review of orchiectomies performed at our institution between 2007 and 2013 for testicular GCTs were performed. RESULTS: Seminomas grossed by residents had a higher rate of reported LVI compared with specimens grossed by pathology assistants (46% vs 15%)...
March 2016: American Journal of Clinical Pathology
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