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JOURNAL ARTICLE
Joanne McPeake, Theodore J Iwashyna, Pamela MacTavish, Helen Devine, Phil Henderson, Tara Quasim, Martin Shaw
BACKGROUND: There is limited evidence to understand what impact, if any, recovery services might have for patients across the socioeconomic spectrum after critical illness. We analysed data from a multicentre critical care recovery programme to understand the impact of this programme across the socioeconomic spectrum. METHODS: The setting for this pre-planned secondary analysis was a critical care rehabilitation programme-Intensive Care Syndrome: Promoting Independence and Return to Employment...
March 2024: BJA Open
#2
JOURNAL ARTICLE
Shuoyan Xiong, Alexandria Hong, Priyabrata Ghana, Brad C Bailey, Heather A Spinney, Hannah Bailey, Briana S Henderson, Steve Marshall, Theodor Agapie
Polar monomer-induced β-H elimination is a key elementary step in polar polyolefin synthesis by coordination polymerization but remains underexplored. Herein, we show that a bulky neutral Ni catalyst, 1 Ph , is not only a high-performance catalyst in ethylene/acrylate copolymerization (activity up to ∼37,000 kg/(mol·h) at 130 °C in a batch reactor, mol % tBA ∼ 0.3) but also a suitable platform for investigation of acrylate-induced β-H elimination. 4 Ph- t Bu , a novel Ni alkyl complex generated after acrylate-induced β-H elimination and subsequent acrylate insertion, was identified and characterized by crystallography...
November 22, 2023: Journal of the American Chemical Society
#3
JOURNAL ARTICLE
Raz Bar-Ziv, Naibedya Dutta, Adam Hruby, Edward Sukarto, Maxim Averbukh, Athena Alcala, Hope R Henderson, Jenni Durieux, Sarah U Tronnes, Qazi Ahmad, Theodore Bolas, Joel Perez, Julian G Dishart, Matthew Vega, Gilberto Garcia, Ryo Higuchi-Sanabria, Andrew Dillin
The nervous system plays a critical role in maintaining whole-organism homeostasis; neurons experiencing mitochondrial stress can coordinate the induction of protective cellular pathways, such as the mitochondrial unfolded protein response (UPRMT ), between tissues. However, these studies largely ignored nonneuronal cells of the nervous system. Here, we found that UPRMT activation in four astrocyte-like glial cells in the nematode, Caenorhabditis elegans , can promote protein homeostasis by alleviating protein aggregation in neurons...
October 13, 2023: Science Advances
#4
Raz Bar-Ziv, Naibedya Dutta, Adam Hruby, Edward Sukarto, Maxim Averbukh, Athena Alcala, Hope R Henderson, Jenni Durieux, Sarah U Tronnes, Qazi Ahmad, Theodore Bolas, Joel Perez, Julian G Dishart, Matthew Vega, Gilberto Garcia, Ryo Higuchi-Sanabria, Andrew Dillin
UNLABELLED: The nervous system plays a critical role in maintaining whole-organism homeostasis; neurons experiencing mitochondrial stress can coordinate the induction of protective cellular pathways, such as the mitochondrial unfolded protein response (UPR MT ), between tissues. However, these studies largely ignored non-neuronal cells of the nervous system. Here, we found that UPR MT activation in four, astrocyte-like glial cells in the nematode, C. elegans , can promote protein homeostasis by alleviating protein aggregation in neurons...
August 8, 2023: bioRxiv
#5
JOURNAL ARTICLE
Joseph A Carnevale, Abhinav Pandey, Cristopher Ramirez-Loera, Jacob L Goldberg, Evan D Bander, Fraser Henderson, Sumit N Niogi, Abtin Tabaee, Ashutosh Kacker, Vijay K Anand, Andrew Kim, Apostolos John Tsiouris, Kyle J Godfrey, Theodore H Schwartz
OBJECTIVE: Minimally invasive endoscope-assisted approaches to the anterior skull base offer an alternative to traditional open craniotomies. Given the restrictive operative corridor, appropriate case selection is critical for success. In this paper, the authors present the results of three different minimal access approaches to meningiomas of the anterior and middle fossae and examine the differences in the target areas considered appropriate for each approach, as well as the outcomes, to determine whether the surgical goals were achieved...
June 30, 2023: Journal of Neurosurgery
#6
JOURNAL ARTICLE
Theodore P Croll, Ben Z Swanson
An unusual card advertising the dental services of T.S. Henderson revives the story of an Irish dentist who left his homeland and came to Brooklyn, New York to practice. He was a fervent Irish Nationalist and was active in Irish causes. Henderson was an abuser of alcohol and eventually found dead in Albany, New York. The death was considered a suicide, but was it?
2023: Journal of the History of Dentistry
#7
JOURNAL ARTICLE
Sarah E Sheppard, Laura Bryant, Rochelle N Wickramasekara, Courtney Vaccaro, Brynn Robertson, Jodi Hallgren, Jason Hulen, Cynthia J Watson, Victor Faundes, Yannis Duffourd, Pearl Lee, M Celeste Simon, Xavier de la Cruz, Natália Padilla, Marco Flores-Mendez, Naiara Akizu, Jacqueline Smiler, Renata Pellegrino Da Silva, Dong Li, Michael March, Abdias Diaz-Rosado, Isabella Peixoto de Barcelos, Zhao Xiang Choa, Chin Yan Lim, Christèle Dubourg, Hubert Journel, Florence Demurger, Maureen Mulhern, Cigdem Akman, Natalie Lippa, Marisa Andrews, Dustin Baldridge, John Constantino, Arie van Haeringen, Irina Snoeck-Streef, Penny Chow, Anne Hing, John M Graham, Margaret Au, Laurence Faivre, Wei Shen, Rong Mao, Janice Palumbos, David Viskochil, William Gahl, Cynthia Tifft, Ellen Macnamara, Natalie Hauser, Rebecca Miller, Jessica Maffeo, Alexandra Afenjar, Diane Doummar, Boris Keren, Pamela Arn, Sarah Macklin-Mantia, Ilse Meerschaut, Bert Callewaert, André Reis, Christiane Zweier, Carole Brewer, Anand Saggar, Marie F Smeland, Ajith Kumar, Frances Elmslie, Charu Deshpande, Mathilde Nizon, Benjamin Cogne, Yvette van Ierland, Martina Wilke, Marjon van Slegtenhorst, Suzanne Koudijs, Jin Yun Chen, David Dredge, Danielle Pier, Saskia Wortmann, Erik-Jan Kamsteeg, Johannes Koch, Devon Haynes, Lynda Pollack, Hannah Titheradge, Kara Ranguin, Anne-Sophie Denommé-Pichon, Sacha Weber, Rubén Pérez de la Fuente, Jaime Sánchez Del Pozo, Jose Miguel Lezana Rosales, Pascal Joset, Katharina Steindl, Anita Rauch, Davide Mei, Francesco Mari, Renzo Guerrini, James Lespinasse, Frédéric Tran Mau-Them, Christophe Philippe, Benjamin Dauriat, Laure Raymond, Sébastien Moutton, Anna M Cueto-González, Tiong Yang Tan, Cyril Mignot, Sarah Grotto, Florence Renaldo, Theodore G Drivas, Laura Hennessy, Anna Raper, Ilaria Parenti, Frank J Kaiser, Alma Kuechler, Øyvind L Busk, Lily Islam, Jacob A Siedlik, Lindsay B Henderson, Jane Juusola, Richard Person, Rhonda E Schnur, Antonio Vitobello, Siddharth Banka, Elizabeth J Bhoj, Holly A F Stessman
Pathogenic variants in KMT5B , a lysine methyltransferase, are associated with global developmental delay, macrocephaly, autism, and congenital anomalies (OMIM # 617788). Given the relatively recent discovery of this disorder, it has not been fully characterized. Deep phenotyping of the largest ( n = 43) patient cohort to date identified that hypotonia and congenital heart defects are prominent features that were previously not associated with this syndrome. Both missense variants and putative loss-of-function variants resulted in slow growth in patient-derived cell lines...
March 10, 2023: Science Advances
#8
JOURNAL ARTICLE
Fraser Henderson, Brett E Youngerman, Sumit N Niogi, Tyler Alexander, Abtin Tabaee, Ashutosh Kacker, Vijay K Anand, Theodore H Schwartz
OBJECTIVE: The aim of this study was to determine if the distinction between planum sphenoidale (PS) and tuberculum sellae (TS) meningiomas is clinically meaningful and impacts the results of the endoscopic endonasal approach (EEA). METHODS: A consecutive series of patients who were 18 years of age or older and underwent EEA for newly diagnosed grade I PS meningiomas (PSMs) and TS meningiomas (TSMs) between October 2007 and May 2021 were included. The PS and TS were distinguished by drawing a line passing through the center of the TS and perpendicular to the PS on postcontrast T1-weighted MRI...
May 1, 2023: Journal of Neurosurgery
#9
JOURNAL ARTICLE
Fraser Henderson, Evgenii Belykh, Alexander D Ramos, Theodore H Schwartz
Fluorescence-guided surgery (FGS) for high-grade gliomas using 5-aminolevulinic acid has become a new standard of care for neurosurgeons in several countries. In this video the authors present the case of a man with glioblastoma who underwent FGS in which similar images of the operative field were acquired alternating between the microscope and a new commercially available headlight, facilitating the comparison of visualization quality between the two devices. The authors also review some of the principles of fluorescence-guidance surgery that may explain the improved brightness and contrast that they observed when using the headlamp versus the microscope...
January 2022: Neurosurgical focus: Video
#10
EDITORIAL
Theodore A Henderson, Philip F Cohen, Giuseppe Cardaci, Jean-Luc C Urbain
No abstract text is available yet for this article.
2022: Frontiers in Psychiatry
#11
REVIEW
Andrew B Yang, Fraser Henderson, Theodore H Schwartz
PURPOSE: Several surgical strategies have been proposed to treat MRI-negative Cushing's Disease. These include tumor removal, if identified, and if a tumor is not identified, resection of varying degrees of the pituitary gland, often guided by inferior petrosal sinus sampling (IPSS). The relative risks and benefits of each strategy have never been compared. METHODS: This systematic review of the literature included only studies on the results of surgery for MRI-negative patients with Cushing's Disease in which the surgical strategy was clearly described and associated remission and/or hypopituitarism rates detailed for each strategy...
August 2022: Pituitary
#12
JOURNAL ARTICLE
Dan G Pavel, Theodore A Henderson, Simon DeBruin, Philip F Cohen
Brain perfusion single photon emission computed tomography (SPECT) scans were initially developed in 1970s. A key radiopharmaceutical, hexamethylpropyleneamine oxime (HMPAO), was not stabilized until 1993 and most early SPECT scans were performed on single-head gamma cameras. These early scans were of inferior quality. In 1996, the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology (TTASAAN) issued a report regarding the use of SPECT in the evaluation of neurological disorders...
2022: Frontiers in Neurology
#13
JOURNAL ARTICLE
Mary McLean, Theodore A Henderson, Dan G Pavel, Phil Cohen
Bipolar disorder is a significant mental illness affecting over 4 million people in North America and approximately 46 million worldwide. While the onset of bipolar disorder is typically in late adolescence and early adulthood, the correct diagnosis can be delayed for several years. This delay can result in inappropriate pharmaceutical interventions, loss of career or productivity, suicide, family hardship, and unnecessary expense. Moreover, prolonged untreated or inappropriately treated bipolar disorder may cause damage to the brain...
2022: Frontiers in Psychiatry
#14
MULTICENTER STUDY
Joanne McPeake, Philip Henderson, Pamela MacTavish, Helen Devine, Malcolm Daniel, Phil Lucie, Lynn Bollan, Lucy Hogg, Mike MacMahon, Sharon Mulhern, Pauline Murray, Laura O'Neill, Laura Strachan, Theodore J Iwashyna, Martin Shaw, Tara Quasim
BACKGROUND: Caregivers and family members of Intensive Care Unit (ICU) survivors can face emotional problems following patient discharge from hospital. We aimed to evaluate the impact of a multi-centre integrated health and social care intervention, on caregiver and family member outcomes. METHODS: This study evaluated the impact of the Intensive Care Syndrome: Promoting Independence and Return to Employment (InS:PIRE) programme across 9 sites in Scotland. InS:PIRE is an integrated health and social care intervention...
May 24, 2022: Critical Care: the Official Journal of the Critical Care Forum
#15
Multilayered macular hemorrhages as an unusual complication of transorbital neuroendoscopic surgery.
William Foulsham, Victoria S North, Benjamin W Botsford, Marc J Dinkin, Fraser Henderson, Kyle J Godfrey, Donald J D'Amico, Theodore H Schwartz, Anton Orlin
Purpose: To report a case of multilayered intraocular hemorrhage at the posterior pole as a complication of transorbital neuroendoscopic surgery. Observations: Our patient underwent an uncomplicated endoscopic transorbital resection of a left sphenoid wing meningioma. In the immediate post-operative period, the patient reported blurred vision of her left eye, and dilated fundus examination demonstrated multilayered hemorrhages at the posterior pole. No intracranial hemorrhage was identified on post-operative imaging...
June 2022: American Journal of Ophthalmology Case Reports
#16
JOURNAL ARTICLE
Fraser Henderson, Victoria S North, Theodore H Schwartz
No abstract text is available yet for this article.
May 1, 2022: Operative Neurosurgery (Hagerstown, Md.)
#17
JOURNAL ARTICLE
John F Thornton, Howard Schneider, Philip F Cohen, Simon DeBruin, John Michael Uszler, Yin-Hui Siow, Mary K McLean, Muriel J van Lierop, Dan G Pavel, Theodore A Henderson
In the community, there is a need to more objectively evaluate the response of common chronic psychiatric disorders to treatment. Brain single photon emission computed tomography (SPECT) indirectly measures cerebral functional activity by uptake of a radiotracer, which follows regional cerebral blood flow. Brain 3D Thresholded SPECT scans are thresholded three dimensional images derived from brain SPECT data. A retrospective community study of longitudinal (before and after treatment) brain 3D Thresholded SPECT scans of 73 patients with all-cause psychiatric disorders (most frequent diagnostic clusters: attention-deficit hyperactivity disorder, post-mild traumatic brain injury, affective disorders, psychotic disorders, post-viral chronic syndromes), shows these baseline SPECT scans predict improvement (non-worsening to large improvement) in clinical functioning with a sensitivity of 94% (95% confidence interval 86-98%) and a specificity of 67% (95% confidence interval 21-94%)...
2022: Frontiers in Psychiatry
#18
JOURNAL ARTICLE
Philip Henderson, Tara Quasim, Martin Shaw, Pamela MacTavish, Helen Devine, Malcolm Daniel, Fiona Nicolson, Peter O'Brien, Ashley Weir, Laura Strachan, Lorraine Senior, Phil Lucie, Lynn Bollan, Jane Duffty, Lucy Hogg, Colette Ross, Malcolm Sim, Radha Sundaram, Theodore J Iwashyna, Joanne McPeake
RATIONALE: At present, clinicians aiming to support patients through the challenges after critical care have limited evidence to base interventions. OBJECTIVES: Evaluate a multicentre integrated health and social care intervention for critical care survivors. A process evaluation assessed factors influencing the programme implementation. METHODS: This study evaluated the impact of the Intensive Care Syndrome: Promoting Independence and Return to Employment (InS:PIRE) programme...
March 21, 2022: Thorax
#19
JOURNAL ARTICLE
Theodore H Schwartz, Fraser Henderson, Alberto Di Somma, Doo-Sik Kong, Matteo de Notaris, Joaquim Enseñat, Kris S Moe
No abstract text is available yet for this article.
December 28, 2021: World Neurosurgery
#20
JOURNAL ARTICLE
Daniel G Amen, Theodore A Henderson, Andrew Newberg
Background: The diagnosis of attention deficit hyperactivity disorder (ADHD) relies on history and observation, as no reliable biomarkers have been identified. In this study, we compared a large single diagnosis group of patients with ADHD (combined, inattentive, and hyperactive) to healthy controls using brain perfusion single-photon emission computed tomography (SPECT) imaging to determine specific brain regions which could serve as potential biomarkers to reliably distinguish ADHD. Methods: In a retrospective analysis, subjects ( n = 1,135) were obtained from a large multisite psychiatric database, where resting state (baseline) and on-task SPECT scans were obtained...
2021: Frontiers in Psychiatry
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