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Terpenoids

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https://www.readbyqxmd.com/read/28092849/magnesium-and-manganese-affect-photosynthesis-essential-oil-composition-and-phenolic-compounds-of-tanacetum-parthenium
#1
Soudeh Farzadfar, Fatemeh Zarinkamar, Mostafa Hojati
The accumulation of plant defense metabolites is closely associated with the concentration of nutrient elements, yet data related to the interactive effects of two nutrients on the deployment of phenolics and terpenoids are scare. In the present study, the interaction between magnesium (Mg) and manganese (Mn) on nutrient uptake, photosynthesis, oxidative status and the accumulation of phenolics and terpenoids in the leaves of feverfew plants grown at different concentrations of Mg and Mn was investigated. Nutrient uptake and photosynthesis were associated with the amount of applied Mg but could be modified by the concentration of Mn...
January 3, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28089066/evaluation-and-prevention-of-the-negative-matrix-effect-of-terpenoids-on-pesticides-in-apples-quantification-by-gas-chromatography-tandem-mass-spectrometry
#2
Géraldine Giacinti, Christine Raynaud, Sophie Capblancq, Valérie Simon
The sample matrix can enhance the gas chromatography signal of pesticide residues relative to that obtained with the same concentration of pesticide in solvent. This paper is related to negative matrix effects observed in coupled gas chromatography-mass spectrometry ion trap (GC/MS(2)) quantification of pesticides in concentrated extracts of apple peel prepared by the Quick Easy Cheap Effective Rugged and Safe (QuEChERS) method. It is focused on the pesticides most frequently used on the apple varieties studied, throughout the crop cycle, right up to harvest, to combat pests and diseases and to improve fruit storage properties...
December 21, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28088903/antitubercular-marine-natural-products
#3
Lishu Wang, Jungfeng Wang, Juan Liu, Yonghong Liu
Due to the importance of nature as a source of new drug candidates, the purpose of this article is to emphasize the marine natural products, which exhibit antitubercular activity, published between January 2000 and May 2016, with 138 quotation to 250 compounds obtained from marine resources. These metabolites are organized by chemical constitution and named as simple alkyl lipids derivatives, aromatics derivatives, peptides, alkaloids, terpenoids, steroids, macrolides, and polycyclic polyketides.
January 13, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28088026/current-ambient-concentrations-of-ozone-in-panama-modulate-the-leaf-chemistry-of-the-tropical-tree-ficus-insipida
#4
Gerald F Schneider, Alexander W Cheesman, Klaus Winter, Benjamin L Turner, Stephen Sitch, Thomas A Kursar
Tropospheric ozone (O3) is a major air pollutant and greenhouse gas, affecting carbon dynamics, ecological interactions, and agricultural productivity across continents and biomes. Elevated [O3] has been documented in tropical evergreen forests, the epicenters of terrestrial primary productivity and plant-consumer interactions. However, the effects of O3 on vegetation have not previously been studied in these forests. In this study, we quantified ambient O3 in a region shared by forests and urban/commercial zones in Panama and found levels two to three times greater than in remote tropical sites...
December 27, 2016: Chemosphere
https://www.readbyqxmd.com/read/28087662/terpenoids-in-plant-and-arbuscular-mycorrhiza-reinforced-defence-against-herbivorous-insects
#5
REVIEW
Esha Sharma, Garima Anand, Rupam Kapoor
BACKGROUND: Plants, though sessile, employ various strategies to defend themselves against herbivorous insects and convey signals of an impending herbivore attack to other plant(s). Strategies include the production of volatiles that include terpenoids and the formation of symbiotic associations with fungi, such as arbuscular mycorrhiza (AM). This constitutes a two-pronged above-ground/below-ground attack-defence strategy against insect herbivores. SCOPE: Terpenoids represent an important constituent of herbivore-induced plant volatiles that deter herbivores and/or attract their predators...
January 12, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28086865/rnai-reveals-proteins-for-metabolism-and-protein-processing-associated-with-langat-virus-infection-in-ixodes-scapularis-black-legged-tick-ise6-cells
#6
Jeffrey M Grabowski, Monika Gulia-Nuss, Richard J Kuhn, Catherine A Hill
BACKGROUND: Tick-borne flaviviruses (TBFs) cause thousands of human cases of encephalitis worldwide each year, with some TBF infections progressing to hemorrhagic fever. TBFs are of medical and veterinary importance and strategies to reduce flavivirus transmission by the tick vector may have significant application. Analyses of the proteome of ISE6 cells derived from the black legged tick, Ixodes scapularis infected with the TBF, Langat virus (LGTV), have provided insights into proteins and cellular processes involved with LGTV infection...
January 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28074411/biomass-and-terpenoids-produced-by-mutant-strains-of-arthrospira-under-low-temperature-and-light-conditions
#7
Jian Guan, Songdong Shen, Hao Wu, Xin Liu, Weijie Shen, Yuan He, R Duan
The filamentous Cyanobacterium Arthrospira is commercially produced and is a functional, high-value, health food. We identified 5 low temperature and low light intensity tolerant strains of Arthrospira sp. (GMPA1, GMPA7, GMPB1, GMPC1, and GMPC3) using ethyl methanesulfonate mutagenesis and low temperature screening. The 5 Arthrospira strains grew rapidly below 14 °C, 43.75 μmol photons m(-2) s(-1) and performed breed conservation at 2.5 °C, 8.75 μmol photons m(-2) s(-1). We used morphological identification and molecular genetic analysis to identify GMPA1, GMPA7, GMPB1 and GMPC1 as Arthrospira platensis, while GMPC3 was identified as Arthrospira maxima...
February 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28069689/comparative-evaluation-of-raw-and-ripe-fruits-of-forsythia-suspensa-by-hplc-esi-ms-ms-analysis-and-anti-microbial-assay
#8
Jialin Qu, Xinjia Yan, Chunyan Li, Jing Wen, Chongning Lu, Jungang Ren, Ying Peng, Shaojiang Song
A multi-component quantification fingerprint based on high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry technique has been established for the comparative analysis of raw and ripe fruits of Forsythia suspensa originated from different provinces. Eighteen bioactive constituents including three phenylethanoid glycosides derivatives, six phenolic acids, three flavonoids, four phenylpropanoids, one fatty acid and one terpenoid were identified and quantified. Total contents of phenylethanoid glycosides, phenylpropanoids and flavonoids from raw samples were found much higher than those from ripe samples, while total content of phenolic acids showed a contrary tendency...
January 8, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28069166/evaluation-and-prevention-of-the-negative-matrix-effect-of-terpenoids-on-pesticides-in-apples-quantification-by-gas-chromatography-tandem-mass-spectrometry
#9
Géraldine Giacinti, Christine Raynaud, Sophie Capblancq, Valérie Simon
The sample matrix can enhance the gas chromatography signal of pesticide residues relative to that obtained with the same concentration of pesticide in solvent. This paper is related to negative matrix effects observed in coupled gas chromatography-mass spectrometry ion trap (GC/MS(2)) quantification of pesticides in concentrated extracts of apple peel prepared by the Quick Easy Cheap Effective Rugged and Safe (QuEChERS) method. It is focused on the pesticides most frequently used on the apple varieties studied, throughout the crop cycle, right up to harvest, to combat pests and diseases and to improve fruit storage properties...
December 21, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28067842/biological-importance-of-cotton-by-products-relative-to-chemical-constituents-of-the-cotton-plant
#10
REVIEW
Mary A Egbuta, Shane McIntosh, Daniel L E Waters, Tony Vancov, Lei Liu
Although cultivated for over 7000 years, mainly for production of cotton fibre, the cotton plant has not been fully explored for potential uses of its other parts. Despite cotton containing many important chemical compounds, limited understanding of its phytochemical composition still exists. In order to add value to waste products of the cotton industry, such as cotton gin trash, this review focuses on phytochemicals associated with different parts of cotton plants and their biological activities. Three major classes of compounds and some primary metabolites have been previously identified in the plant...
January 6, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28066031/a-total-synthesis-of-hortonone-c
#11
Doleshwar Niroula, Liam P Hallada, Snezna Rogelj, Rodolfo Tello-Aburto
A total synthesis of the cytotoxic terpenoid hortonone C was accomplished and its absolute stereochemistry confirmed. Intermediate (+)-4 was synthesized using either an asymmetric conjugate addition strategy, or by elaboration of the Hajos-Parrish ketone. Reduction of (+)-4 under dissolving-metal conditions and trapping the enolate intermediate served to control the cis-stereochemistry at the ring fusion and provide a silyl enol ether necessary for ring expansion. Comparison of optical rotation data confirmed that the absolute configuration of natural hortonone C is (6S,7S,10S)...
January 26, 2017: Tetrahedron
https://www.readbyqxmd.com/read/28062071/chemical-profile-and-defensive-function-of-the-latex-of-euphorbia-peplus
#12
Juan Hua, Yan Liu, Chao-Jiang Xiao, Shu-Xi Jing, Shi-Hong Luo, Sheng-Hong Li
Plant latex is an endogenous fluid secreted from highly specialized laticifer cells and has been suggested to act as a plant defense system. The chemical profile of the latex of Euphorbia peplus was investigated. A total of 13 terpenoids including two previously unknown diterpenoids, (2S*,3S*,4R*,5R*,6R*,8R*,l1R*,13S*,14S*,15R*, 16R*)-5,8,15-triacetoxy-3-benzoyloxy-11,16-dihydroxy-9-oxopepluane and (2R*,3R*, 4S*,5R*,7S*,8S*,9S*,l3S*,14S*,15R*)-2,5,8,9,14-pentaacetoxy-3-benzoyloxy-15-hydroxy-7-isobutyroyloxyjatropha-6(17),11E-diene), ten known diterpenoids, and a known acyclic triterpene alcohol peplusol, were identified, using HPLC and UPLC-MS/MS analyses and through comparison with the authentic compounds isolated from the whole plant...
January 3, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28059043/natural-products-as-anticancerous-therapeutic-molecules-with-special-reference-to-enzymatic-targets-topoisomerase-cox-lox-and-aromatase
#13
Swati Singh, Manika Awasthi, Veda P Pandey, Upendra Dwivedi
Cancer, characterized by uncontrolled growth and proliferation of cells, is affecting millions of people every year and estimated as the second leading cause of death. Its successful treatment yet remains a challenge due to the lack of selectivity, toxicity and the development of multi-drug resistant cells to the currently available drugs. Plant derived natural products hold great promise for discovery and development of new pharmaceuticals against cancer as evident by the fact that out of 121 drugs prescribed for cancer treatment till date, 90 are derived from plant sources...
January 5, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28056963/antimalarial-activity-of-syzygium-guineense-during-early-and-established-plasmodium-infection-in-rodent-models
#14
Solomon Asmamaw Tadesse, Zewdu Birhanu Wubneh
BACKGROUND: In Ethiopia, the leaves of Syzygium guineense have been found useful for the prevention and cure of malaria, and demonstrated antiplasmodial activity in vitro. Nevertheless, no scientific study has been conducted to confirm its antimalarial activity in vivo. Therefore, the objective of the study was to evaluate the antimalarial effect of Syzygium guineense leaf extract in mice. METHODS: Inoculation of the study mice was carried out by using the malaria parasite, Plasmodium berghei...
January 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28056932/in-vivo-antimalarial-activity-of-crude-extracts-and-solvent-fractions-of-leaves-of-strychnos-mitis-in-plasmodium-berghei-infected-mice
#15
Selamawit Fentahun, Eyasu Makonnen, Tesfaye Awas, Mirutse Giday
BACKGROUND: Malaria is a major public health problem in the world which is responsible for death of millions particularly in sub-Saharan Africa. Today, the control of malaria has become gradually more complex due to the spread of drug-resistant parasites. Medicinal plants are the unquestionable source of effective antimalarials. The present study aimed to evaluate antiplasmodial activity and acute toxicity of the plant Strychnos mitis in Plasmodium berghei infected mice. METHODS: Standard procedures were employed to investigate acute toxicity and 4-day suppressive effect of crude aqueous and hydro-methanolic extracts of the leaves of Strychnos mitis against P...
January 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28049347/strategies-to-enhance-biologically-active-secondary-metabolites-in-cell-cultures-of-artemisia-current-trends
#16
Mohammad Ali, Bilal Haider Abbasi, Nisar Ahmad, Haji Khan, Gul Shad Ali
The genus Artemisia has been utilized worldwide due to its immense potential for protection against various diseases, especially malaria. Artemisia absinthium, previously renowned for its utilization in the popular beverage absinthe, is gaining resurgence due to its extensive pharmacological activities. Like A. annua, this species exhibits strong biological activities like antimalarial, anticancer and antioxidant. Although artemisinin was found to be the major metabolite for its antimalarial effects, several flavonoids and terpenoids are considered to possess biological activities when used alone and also to synergistically boost the bioavailability of artemisinin...
January 3, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28045448/molecular-cloning-characterization-and-functional-analysis-of-acetyl-coa-c-acetyltransferase-and-mevalonate-kinase-genes-involved-in-terpene-trilactone-biosynthesis-from-ginkgo-biloba
#17
Qiangwen Chen, Jiaping Yan, Xiangxiang Meng, Feng Xu, Weiwei Zhang, Yongling Liao, Jinwang Qu
Ginkgolides and bilobalide, collectively termed terpene trilactones (TTLs), are terpenoids that form the main active substance of Ginkgo biloba. Terpenoids in the mevalonate (MVA) biosynthetic pathway include acetyl-CoA C-acetyltransferase (AACT) and mevalonate kinase (MVK) as core enzymes. In this study, two full-length (cDNAs) encoding AACT (GbAACT, GenBank Accession No. KX904942) and MVK (GbMVK, GenBank Accession No. KX904944) were cloned from G. biloba. The deduced GbAACT and GbMVK proteins contain 404 and 396 amino acids with the corresponding open-reading frame (ORF) sizes of 1215 bp and 1194 bp, respectively...
January 2, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28045196/mechanistic-studies-of-sesquiterpene-cyclases-based-on-their-carbon-isotope-ratios-at-natural-abundance
#18
Wenhua Tan, Stefan Bartram, Wilhelm Boland
During the process of terpene biosynthesis, C-C bond breaking and forming steps are subjected to kinetic carbon isotope effects, leading to distinct carbon isotopic signatures of the products. Accordingly, carbon isotopic signatures could be used to reveal the "biosynthetic history" of the produced terpenoids. Five known sesquiterpene cyclases, regulating three different pathways, representing simple to complex biosynthetic sequences, were heterologously expressed and used for in vitro assays with farnesyl diphosphate as substrate...
January 3, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28042460/asperterpenes-a-and-b-two-unprecedented-meroterpenoids-from-aspergillus-terreus-with-bace1-inhibitory-activities
#19
Changxing Qi, Jian Bao, Jianping Wang, Hucheng Zhu, Yongbo Xue, Xiaochuan Wang, Hua Li, Weiguang Sun, Weixi Gao, Yongji Lai, Jian-Guo Chen, Yonghui Zhang
Asperterpenes A (1) and B (2), two 3,5-dimethylorsellinic acid-based meroterpenoids that contain a unique β-oriented Me-21 with an unprecedented 1,2,5-trimethyl-4,9-dioxobicyclo[3.3.1]non-2-ene-3-carboxylic acid moiety, were obtained from Aspergillus terreus in very limited amounts of 3.6 mg and 1.8 mg, respectively. The absolute structure of 1 was determined using X-ray diffraction. Because of the low yield of 1, a comprehensive characterization of the BACE1 inhibitory activities of 1 was completed via molecular biological, cell and animal studies guided by in silico target confirmation (ISTC)...
October 19, 2016: Chemical Science
https://www.readbyqxmd.com/read/28040409/antifungal-effects-of-phytocompounds-on-candida-species-alone-and-in-combination-with-fluconazole
#20
REVIEW
Mengjiao Lu, Tao Li, Jianjian Wan, Xiuyun Li, Lei Yuan, Shujuan Sun
Invasive fungal infections caused by Candida spp. remain the most predominant nosocomial fungal infections. Owing to the increased use of antifungal agents, resistance of Candida spp. to antimycotics has emerged frequently, especially to fluconazole (FLC). To cope with this issue, new efforts have been dedicated to discovering novel antimycotics or new agents that can enhance the susceptibility of Candida spp. to existing antimycotics. The secondary metabolites of plants represent a large library of compounds that are important sources for new drugs or compounds suitable for further modification...
December 15, 2016: International Journal of Antimicrobial Agents
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