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Xiao-Mei Fang, Jing-Lin Bai, Jing Su, Li-Li Zhao, Hong-Yu Liu, Bai-Ping Ma, Yu-Qin Zhang, Li-Yan Yu
Three actinomycete strains originating from the surface-sterilized roots of Paris polyphylla were characterized by using a polyphasic approach. Phylogenetic analyses based on the 16S rRNA gene sequence showed that they formed a deep, monophyletic branch in the genus Glycomyces, and were most closely related to the type strains of the species Glycomyces harbinensis and Glycomycesscopariae. Morphological and chemotaxonomic data supported the affiliation of strains CPCC 204357T , CPCC 204354 and CPCC 204355 to the genus Glycomyces...
March 16, 2018: International Journal of Systematic and Evolutionary Microbiology
Hathairat Rachniyom, Atsuko Matsumoto, Yuki Inahashi, Akira Take, Yoko Takahashi, Arinthip Thamchaipenet
A novel actinomycete strain, designated GKU 128T , isolated from the roots of an Indian oak tree [Barringtonia acutangula (L.) Gaertn.] at Khao Khitchakut district, Chantaburi province, Thailand, was characterized by using a polyphasic approach. The strain formed a branched substrate and aerial mycelia which differentiated into straight to flexuous chains of smooth-ornamented spores. Analysis of the cell wall revealed the presence of meso-diaminopimelic acid and N-acetylmuramic acid in the peptidoglycan. The whole-cell sugars were glucose, madurose, mannose, rhamnose and ribose...
March 15, 2018: International Journal of Systematic and Evolutionary Microbiology
Hyo-Jin Lee, Kyung-Sook Whang
Three actinomycetes strains, designated JBL-5, JBL-14 and JBL-20T , were isolated from bamboo (Sasa borealis) litter in Damyang, Republic of Korea. Morphological, chemotaxonomic and phylogenetic analyses demonstrated that the three strains belong to the genus Streptomyces. Microscopic observation revealed that the three strains produced Spirales spore chains with smooth surfaces. Phylogenetic analysis based on 16S rRNA gene sequence comparisons revealed that these strains showed the highest sequence similarity to Streptomyces gelaticus NRRL B-2928T (97...
March 14, 2018: International Journal of Systematic and Evolutionary Microbiology
Dongmei Li, Weiwei Zheng, Junwei Zhao, Liyuan Han, Xueli Zhao, Hao Jiang, Xiangjing Wang, Wensheng Xiang
A novel actinobacterium, designated strain NEAU-LZC 7T , was isolated from soil collected from Mount Song and characterized using a polyphasic approach. Phylogenetic analysis based on 16S rRNA gene sequence indicated that strain NEAU-LZC 7T belonged to the genus Lentzea, with highest sequence similarity to Lentzea violacea JCM 10975T (98.1 %). Morphological and chemotaxonomic characteristics of the strain also supported its assignment to the genus Lentzea. However, DNA-DNA relatedness, physiological and biochemical data showed that strain NEAU-LZC 7T could be distinguished from its closest relative...
March 14, 2018: International Journal of Systematic and Evolutionary Microbiology
Chitti Thawai
A novel actinomycete, designated strain DH51B-4-3T , which formed long chains of spherical spores borne on the tip of sporophores arising from the aerial mycelium, was isolated from rice rhizosphere soil. The isolate contained meso-diaminopimelic acid in the cell-wall peptidoglycan. The whole-cell sugars of strain DH51B-4-3T were arabinose, galactose, glucose, rhamnose and ribose. The phospholipids in the cell membrane were phosphatidylethanolamine, phosphatidyl methylethanolamine, diphosphatidylglycerol and phosphatidylinositol...
March 14, 2018: International Journal of Systematic and Evolutionary Microbiology
R Andler, S Hiessl, O Yücel, M Tesch, A Steinbüchel
Potential biotechnological recycling processes for rubber products include the bacterial degradation of poly(cis-1,4-isoprene) (IR) in order to achieve its total biodegradation or its biotransformation into useful products. The actinomycete Gordonia polyisoprenivorans strain VH2 catalyzes the degradation of IR and enables its use as a sole carbon source via β-oxidation. The initial cleavage reaction is catalyzed by the extracellular latex clearing protein (Lcp). This dioxygenase is the key enzyme for the formation of oligo(cis-1,4-isoprene) molecules with different lengths, i...
March 9, 2018: New Biotechnology
Govindan Rajivgandhi, Ramachandran Vijayan, Muthuchamy Maruthupandy, Baskaralingam Vaseeharan, Natesan Manoharan
Urinary tract infections (UTIs) are a diverse public health complication and are caused by range of pathogens, however most often by Gram negative bacteria which cause significant life threatening risks to different populations. The prevalence rate and antimicrobial resistance among the Gram negative uropathogens alarmed to significantly heighten the economic burden of these infections. In this study, we investigated the role of Pyrrolo[1,2-a] pyrazine-1,4-dione,hexahydro-3-(2-methylpropyl) on endophytic actinomycetes Nocardiopsis sp...
March 7, 2018: Microbial Pathogenesis
Jing Jin, Xiaoyan Yang, Tan Liu, Hua Xiao, Guiyang Wang, Mengjie Zhou, Fawang Liu, Yingtao Zhang, Dong Liu, Minghua Chen, Wei Cheng, Donghui Yang, Ming Ma
Aromatic polyketides from marine actinomycetes have received increasing attention due to their unusual structures and potent bioactivities. Compared to their terrestrial counterparts, marine aromatic polyketides have been less discovered and their structural and biological diversities are far from being fully investigated. In this study, we employed a PCR-based genome mining method to discover aromatic polyketides in our marine bacteria collection. Five new atypical angucyclinones, fluostatins M-Q ( 1 - 5 ) featuring a unique 6-5-6-6 ring skeleton, were discovered from one "positive" Streptomyces sp...
March 9, 2018: Marine Drugs
Watsana Penkhrue, Kanaporn Sujarit, Takuji Kudo, Moriya Ohkuma, Kazuo Masaki, Tomoyasu Aizawa, Wasu Pathom-Aree, Chartchai Khanongnuch, Saisamorn Lumyong
A novel bioplastic-degrading actinomycete, strain SCM_MK2-4T , was isolated from paddy soil in Thailand. The 16S rRNA gene sequence showed that strain SCM_MK2-4T belonged to the genus Amycolatopsis, with the highest sequence similarity to Amycolatopsisazurea JCM 3275T (99.4 %), and was phylogenetically clustered with this strain along with Amycolatopsislurida JCM 3141T (99.3 %), A. japonica DSM 44213T (99.2 %), A. decaplanina DSM 44594T (99.0 %), A. roodepoortensis M29T (98.9 %), A. keratiniphilasubsp...
March 8, 2018: International Journal of Systematic and Evolutionary Microbiology
Tōru Kimura, Yuki Inahashi, Hirotaka Matsuo, Takuya Suga, Masato Iwatsuki, Kazuro Shiomi, Yōko Takahashi, Satoshi Ōmura, Takuji Nakashima
Two new antibiotics, designated pyrizomicin A and B, were isolated from the cultured broth of a rare actinomycete strain, Lechevalieria aerocolonigenes K10-0216, by silica gel and HPLC purification. The chemical structures of pyrizomicin A and B were elucidated as new thiazolyl pyridine compounds by nuclear magnetic resonance and mass spectrometry. Pyrizomicin A and B both showed antimicrobial activity.
March 7, 2018: Journal of Antibiotics
D Raszka, S Popelka, J Heřt, D Jahoda, I Landor, P Vavřík
Nocardiosis is a rare infection caused by the aerobic actinomycete of the Nocardia genus. In most cases, nocardiosis manifests as a lung infection or a bone lesion. Due to the nonspecific and mild clinical manifestations of nocardiosis, the establishment of definite diagnosis can be difficult. When antibiotic therapy is incorrectly targeted, only the symptoms of the disease are suppressed. The mainstay in the treatment of Nocardia osteomyelitis has so far been the combined surgical debridement with long-term, initially intravenous, antibiotic administration...
March 5, 2018: Folia Microbiologica
Thao Bich Nguyen, Shigeru Kitani, Shuichi Shimma, Takuya Nihira
In streptomycetes, autoregulators are important signaling compounds that trigger secondary metabolism, and they are regarded as Streptomyces hormones based on their extremely low effective concentrations (nM) and the involvement of specific receptor proteins. Our previous distribution study revealed that butenolide-type Streptomyces hormones, including avenolide, are a general class of signaling molecules in streptomycetes and that Streptomyces albus J1074 may produce butenolide-type Streptomyces hormones. Here, we describe metabolite profiling of a disruptant of the S...
March 2, 2018: Applied and Environmental Microbiology
Larissa Buedenbender, Leesa J Habener, Tanja Grkovic, D İpek Kurtböke, Sandra Duffy, Vicky M Avery, Anthony R Carroll
Microbial products are a promising source for drug leads as a result of their unique structural diversity. However, reisolation of already known natural products significantly hampers the discovery process, and it is therefore important to incorporate effective microbial isolate selection and dereplication protocols early in microbial natural product studies. We have developed a systematic approach for prioritization of microbial isolates for natural product discovery based on heteronuclear single-quantum correlation-total correlation spectroscopy (HSQC-TOCSY) nuclear magnetic resonance profiles in combination with antiplasmodial activity of extracts...
March 2, 2018: Journal of Natural Products
Ting Gong, Xin Zhen, Xing-Lun Li, Jing-Jing Chen, Tian-Jiao Chen, Jin-Ling Yang, Ping Zhu
A new spirotetronate glycoside tetrocarcin Q ( 1 ) and six known analogues tetrocarcin A ( 2 ), AC6H ( 3 ), tetrocarcin N ( 4 ), tetrocarcin H ( 5 ), arisostatin A ( 6 ), and tetrocarcin F1 ( 7 ) were isolated from the fermentation broth of the marine-derived actinomycete Micromonospora carbonacea LS276. Their chemical structures were established on the basis of 1D- and 2D-NMR spectroscopy, as well as HR-ESI-MS analysis. The absolute configurations of their stereogenic carbons were determined by circular dichroism (CD) analysis...
February 24, 2018: Marine Drugs
Chengrong Nie, Xing Yang, Nabeel Khan Niazi, Xiaoya Xu, Yuhui Wen, Jörg Rinklebe, Yong Sik Ok, Song Xu, Hailong Wang
In the current study, we conducted a field experiment using the test plant, Brassica chinesis L. (pak choi), to investigate the effect of sugarcane bagasse-derived biochar on the bioavailability of cadmium (Cd), copper (Cu) and lead (Pb), and the health of soil microbiota in a contaminated soil. Biochar application significantly (P < 0.05) increased pak choi yield. Bioavailability of heavy metals to plant shoots and roots decreased with increasing biochar application rates (at 0, 1.5, 2.25 and 3.0 t ha-1 )...
February 22, 2018: Chemosphere
Robert Howlett, Katri Anttonen, Nicholas Read, Margaret C M Smith
Actinomycete bacteria use polyprenol phosphate mannose as a lipid linked sugar donor for extra-cytoplasmic glycosyl transferases that transfer mannose to cell envelope polymers, including glycoproteins and glycolipids. We showed recently that strains of Streptomyces coelicolor with mutations in the gene ppm1 encoding polyprenol phosphate mannose synthase were both resistant to phage φC31 and have greatly increased susceptibility to antibiotics that mostly act on cell wall biogenesis. Here we show that mutations in the genes encoding enzymes that act upstream of Ppm1 in the polyprenol phosphate mannose synthesis pathway can also confer phage resistance and antibiotic hyper-susceptibility...
March 1, 2018: Microbiology
Juan Vásquez, Carlos Gómez, Angela Chiquillo, Luz Pescador
Actinomycosis is very rare, as well as the central nervous system (CNS) condition associated with it, presenting a mortality up to 28%. Its manifestations could be similar to infectious conditions from other etiologies, thus, having a better understanding of the entity increases clinical suspicion and also it can provide a timely treatment. The clinical case of an adult with edema in an upper extremity is presented as a manifestation of thrombophlebitis and an abscessed axillary lesion, in which actinomycetes infection was confirmed...
December 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
Somaye Mazkour, Saeid Hosseinzadeh, Seyed Shahram Shekarforoush
Background and Objectives: In the present study, the Lut Desert, Iran was chosen as one of the hottest places in the world (with the recorded temperature of 70.7°C during 2003-2009) to find out whether any heat-resistant microorganisms were present in the soil. Materials and Methods: The samples were collected from surface and depth of three identified places of Gandom Beryan in the Lut Desert. Chemical analysis and enumeration of the total bacteria, yeasts and molds were performed...
December 2017: Iranian Journal of Microbiology
Chitti Thawai
A novel actinomycete, designated strain NW8-21T , was isolated from mountain soil in Mae-Wong National Park, Nakornsawan province, Thailand, and was taxonomically characterized by using a polyphasic approach. Based on 16S rRNA gene sequence analysis, the strain was revealed to have the closest similarity to Pseudonocardia endophytica YIM 56035T with the highest 16S rRNA gene sequence similarity value of 98.7 %, followed by Pseudonocardia nantongensis KLBMP 1282T (98.0 %). The chemotaxonomic properties, i...
February 27, 2018: International Journal of Systematic and Evolutionary Microbiology
C Subathra Devi, V Mohanasrinivasan, Priyanka Devi Verma, Shruthi Chaterjee, S Merlyn Keziah
Fibrinolytic enzymes must currently originate a significant product in the arena of medical research. Very limited studies are stated on fibrinolyticenzyme production from actinomycetes.Streptomyces sp. isolated from marine soil was chosen to optimize its fibrinolytic protease production. 16s rRNA sequencing confirmed the isolated potent strain to be Streptomyces rubiginosus VITPSSM. A fibrinolytic protease was then purified from Streptomyces rubiginosus VITPSSM, with the target of producing a cost effective feasible enzyme from a potential actinomycete...
February 26, 2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
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