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https://www.readbyqxmd.com/read/27911391/a-murine-model-of-group-b-streptococcus-vaginal-colonization
#1
Kathryn A Patras, Kelly S Doran
Streptococcus agalactiae (group B Streptococcus, GBS), is a Gram-positive, asymptomatic colonizer of the human gastrointestinal tract and vaginal tract of 10 - 30% of adults. In immune-compromised individuals, including neonates, pregnant women, and the elderly, GBS may switch to an invasive pathogen causing sepsis, arthritis, pneumonia, and meningitis. Because GBS is a leading bacterial pathogen of neonates, current prophylaxis is comprised of late gestation screening for GBS vaginal colonization and subsequent peripartum antibiotic treatment of GBS-positive mothers...
November 16, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27908639/animal-models-of-respiratory-syncytial-virus-infection
#2
Geraldine Taylor
Human respiratory syncytial virus (hRSV) is a major cause of respiratory disease and hospitalisation of infants, worldwide, and is also responsible for significant morbidity in adults and excess deaths in the elderly. There is no licensed hRSV vaccine or effective therapeutic agent. However, there are a growing number of hRSV vaccine candidates that have been developed targeting different populations at risk of hRSV infection. Animal models of hRSV play an important role in the preclinical testing of hRSV vaccine candidates and although many have shown efficacy in preclinical studies, few have progressed to clinical trials or they have had only limited success...
November 29, 2016: Vaccine
https://www.readbyqxmd.com/read/27904100/usefulness-of-oral-care-related-information-provision-at-drugstores-to-prevent-pneumonia
#3
Masaru Mizoguchi, Sako Kuwano, Ikuko Suzuki, Masato Shigeyama
 Although the removal of bacteria in the oral cavity is regarded as an important preventive measure against pneumonia, the majority of elderly individuals are rarely provided with oral care-related information. This study examined the usefulness of oral care-related information provision for the elderly by pharmacists working at drugstores. A questionnaire survey was conducted, involving 387 pharmacists working at drugstores and 51 elderly individuals who visited such stores. Oral care-related information had been actively provided by 14...
2016: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/27894495/rib-fracture-fixation-indications-and-outcomes
#4
REVIEW
Lara Senekjian, Raminder Nirula
Rib fractures are a frequently identified injury in the trauma population. Not only are multiple rib fractures painful, but they are associated with an increased risk of adverse outcomes. Pneumonia in particular can be devastating, especially to an elderly patient, but other complications such as prolonged ventilation and increased intensive care and hospital durations of stay have a negative impact on the patient. Computed tomography scan is the best modality to diagnosis rib fractures but the treatment of fractures is still evolving...
January 2017: Critical Care Clinics
https://www.readbyqxmd.com/read/27893998/influenza-and-rhinovirus-viral-load-and-disease-severity-in-upper-respiratory-tract-infections
#5
Andrea Granados, Adriana Peci, Allison McGeer, Jonathan B Gubbay
BACKGROUND: The role of viral load in respiratory viral infection is unclear. It is proposed that the viral load of some, but not all respiratory viruses correlate with disease severity. OBJECTIVES: We aimed to determine if an association exists between viral loads among patients in ambulatory settings, compared to those requiring hospitalization/intensive care unit (ICU) admission with influenza A/H3N2, influenza B, or human rhinovirus (HRV); we also explored the impact of age, gender and co-detection of Streptococcus pneumoniae on patient setting...
November 22, 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27892875/the-zoonotic-potential-of-lactococcus-garvieae-an-overview-on-microbiology-epidemiology-virulence-factors-and-relationship-with-its-presence-in-foods
#6
REVIEW
Alicia Gibello, Fátima Galán-Sánchez, M Mar Blanco, Manuel Rodríguez-Iglesias, Lucas Domínguez, José F Fernández-Garayzábal
Lactococcus garvieae is a relevant worldwide fish pathogen affecting various farmed and wild marine and freshwater species. It has also been isolated from other animals, such as ruminants with subclinical mastitis and pigs with pneumonia. From the early 90s, L. garvieae has been associated with different human infections, mainly endocarditis. During the last five years, human infections by this bacterium appear to be increasing, likely due to the improvement in microbiological methods for bacterial identification and the alertness of this bacterium by physicians...
September 17, 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27885231/two-elderly-patients-with-difficult-to-treat-acquired-hemophilia-a
#7
Makoto Saito, Masanobu Morioka
We herein report the cases of two elderly patients with acquired hemophilia A (AHA) for whom treatment was difficult.An 89-year-old woman (Case 1) was admitted to our department with subcutaneous hemorrhage and melena. Her activated partial thromboplastin time (APTT), factor VIII activity, and factor VIII inhibitor level were 127.7 seconds, 1.0%, and 48 BU/mL, respectively, which was suggestive of AHA. The administration of prednisolone (PSL 0.5 mg/kg) was initiated. After 3 weeks, PSL was combined with cyclophosphamide (CPA 50 mg)...
2016: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
https://www.readbyqxmd.com/read/27885228/factors-associated-with-the-prognosis-of-elderly-patients-with-advanced-dementia-who-receive-palliative-care-from-geriatric-health-services-facilities
#8
Keizo Sakai, Yasuhiko Masuda, Kunio Miyanishi
AIM: The aim of the present study is to identify the factors associated with the prognosis of advanced dementia patients who are newly admitted to a geriatric health services facility. METHODS: This retrospective cohort study used data that were obtained on admission in the care-assessment of long-term care facility patients. The 177 participants with advanced dementia were admitted to our facility between 2006 and 2013. The association between the factors in the care-assessment and the three-month-mortality rates were examined throughout the year...
2016: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
https://www.readbyqxmd.com/read/27885198/the-difference-between-ideal-and-actual-fasting-duration-in-the-treatment-of-patients-with-aspiration-pneumonia-a-nationwide-survey-of-clinicians-in-japan
#9
Tsuneaki Kenzaka, Koki Kosami, Yasufumi Matsuoka, Ayako Noda, Ayako Kumabe
In Japan, aspiration pneumonia is common among the elderly and patients are often treated by temporary discontinuation of meals. However, there are few published studies on the fasting duration for aspiration pneumonia treatment. Therefore, we conducted the present study to assess the opinions of clinicians regarding the fasting duration for the treatment of patients with aspiration pneumonia and the actual medical practice with regard to oral ingestion in hospitalized patients with aspiration pneumonia. We targeted hospitals with internal medicine and respiratory medicine departments across Japan...
2016: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27884117/erratum-to-hospitalization-costs-for-community-acquired-pneumonia-in-dutch-elderly-an-observational-study
#10
Conrad E Vissink, Susanne M Huijts, G Ardine de Wit, Marc J M Bonten, Marie-Josée J Mangen
No abstract text is available yet for this article.
November 24, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27874977/relationship-between-age-and-trajectories-of-rehospitalization-risk-in-older-adults
#11
Kumar Dharmarajan, Angela Hsieh, Rachel P Dreyer, Jack Welsh, Li Qin, Harlan M Krumholz
OBJECTIVES: To characterize the magnitude and duration of risk of rehospitalization according to age after hospitalization for heart failure (HF), acute myocardial infarction (AMI), or pneumonia. DESIGN: Retrospective cohort study. SETTING: U.S. hospitals (n = 4,767). PARTICIPANTS: All Medicare fee-for-service beneficiaries aged 65 and older surviving hospitalization for HF, AMI, or pneumonia between October 2012 and December 2013...
November 22, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27867430/evaluation-in-mouse-model-of-combined-virus-bacterial-vaccine-based-on-attenuated-influenza-a-h7n3-virus-and-the-group-b-streptococcus-recombinant-polypeptides
#12
Yulia A Desheva, Galina F Leontieva, Tatiana A Kramskaya, Tatiana A Smolonogina, Kornelia B Grabovskaya, Irina V Kiseleva, Larisa G Rudenko, Alexander N Suvorov
BACKGROUND: Secondary bacterial influenza complications are a common cause of excesses morbidity and mortality, which determines the need to develop means for specific prophylaxis. Group B streptococcal infection is especially common cause of pneumonia among children and the elderly with underlying conditions. Here we investigate in a mouse model the effects of combined intranasal immunization using live attenuated influenza vaccine and recombinant polypeptides based on group B Streptococcus surface proteins...
2016: Open Microbiology Journal
https://www.readbyqxmd.com/read/27865876/interstitial-lung-disease-in-the-elderly
#13
Karen C Patterson, Rupal J Shah, Mary K Porteous, Jason D Christie, Carly D'Errico, Matthew Chadwick, Matthew Triano, Charuhas Deshpande, Milton D Rossman, Leslie A Litzky, Maryl E Kreider, Wallace T Miller
BACKGROUND: Despite the relationship of idiopathic pulmonary fibrosis (IPF) with advancing age, little is known about the epidemiology of interstitial lung diseases (ILD) in the elderly. Here we describe the diagnoses, clinical characteristics, and outcomes of patients who were elderly at the time of ILD diagnosis. METHODS: Among subjects from a prospective cohort study of ILD, elderly was defined as age > 70. Diagnoses were derived from a multi-disciplinary review...
November 16, 2016: Chest
https://www.readbyqxmd.com/read/27846277/pneumococcal-conjugated-vaccine-reduces-the-high-mortality-for-community-acquired-pneumonia-in-the-elderly-an-italian-regional-experience
#14
Vincenzo Baldo, Silvia Cocchio, Tolinda Gallo, Patrizia Furlan, Pierantonio Romor, Chiara Bertoncello, Alessandra Buja, Tatjana Baldovin
BACKGROUND: Community-acquired pneumonia (CAP) is an important cause of illness and death worldwide, particularly among the elderly. Previous studies on the factors associated with mortality in patients hospitalized for CAP revealed a direct association between the type of microorganism involved, the characteristics of the patient and mortality. Vaccination status against pneumococcal disease was not considered. We conducted a retrospective analysis on the mortality rates after a first hospitalization for CAP in north-east Italy with a view to examining especially the role of anti-pneumococcal vaccination as a factor associated with pneumonia-related mortality at one year...
2016: PloS One
https://www.readbyqxmd.com/read/27842985/status-epilepticus-in-the-elderly-patients-a-national-data-study-in-thailand
#15
Somsak Tiamkao, Sineenard Pranboon, Kaewjai Thepsuthammarat, Kittisak Sawanyawisuth
There are limited data in terms of incidence, clinical features, and outcomes in elderly patients with status epilepticus (SE) in national level. We retrospectively explored national data in Thailand for reimbursement of all SE in elderly patients admitted in the fiscal year 2004-2012. SE in elderly patients (age>60years old) were diagnosed and searched based on ICD 10 (G41) from the national database of from the National Health and Security Office. There were 3326 SE in elderly patients. The national incidence of SE was highest at 8...
November 9, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27837335/vibrio-cholerae-non-o1-non-o139-bacteraemia-associated-with-pneumonia-italy-2016
#16
Serena Marinello, Giulia Marini, Giancarlo Parisi, Lorena Gottardello, Lucia Rossi, Valeria Besutti, Anna Maria Cattelan
This paper describes an elderly male patient, living in the Veneto Region, Italy, who developed Vibrio cholerae bacteraemia and pneumonia. Some days previously, while on holiday in the Lagoon of Venice, he had been collecting clams in seawater, during which he suffered small abrasions of the skin. On admission to hospital, he was confused, had fever and a cough, but neither diarrhoea nor signs of gastroenteritis were found. Both blood and stool cultures grew V. cholerae of non-O1 non-O-139 type, and the patient recovered after prompt administration of intravenous ceftriaxone for 2 weeks...
November 11, 2016: Infection
https://www.readbyqxmd.com/read/27832976/linezolid-versus-vancomycin-for-nosocomial-pneumonia-due-to-methicillin-resistant-staphylococcus-aureus-in-the-elderly-a-retrospective-cohort-analysis-effectiveness-of-linezolid-in-the-elderly
#17
Hiroaki Takada, Toru Hifumi, Naoki Nishimoto, Takashi Kanemura, Hayato Yoshioka, Ichiro Okada, Nobuaki Kiriu, Junichi Inoue, Yuichi Koido, Hiroshi Kato
OBJECTIVES: Several reports have compared the efficacy of linezolid (LZD) in Methicillin-resistant Staphylococcus aureus (MRSA) infections with that of vancomycin (VCM); however, these two antibiotics for the treatment of nosocomial MRSA pneumonia in elderly patients has not been well evaluated. The purpose of this study is to evaluate the efficacy and safety of LZD compared with VCM for the treatment of elderly patients with nosocomial MRSA pneumonia in a retrospective chart review of a cohort...
October 29, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27832114/seasonal-influenza-a-h1n1pdm09-virus-and-severe-outcomes-a-reason-for-broader-vaccination-in-non-elderly-at-risk-people
#18
Elisa Minchole, Ana L Figueredo, Manuel Omeñaca, Carolina Panadero, Laura Royo, Jose J Vengoechea, Sergio Fandos, Francisco de Pablo, Salvador Bello
BACKGROUND: Recent pandemics of influenza A H1N1pdm09 virus have caused severe illness, especially in young people. Very few studies on influenza A H1N1pdm09 in post-pandemic periods exist, and there is no information on the severity of both seasonal influenza A(H1N1) and A(H3N2) from the same season, adjusting for potential confounders, including vaccine. METHODS AND RESULTS: We performed a retrospective observational study of adults hospitalized during the 2014 season with influenza A(H1N1) or A(H3N2)...
2016: PloS One
https://www.readbyqxmd.com/read/27824151/the-antimicrobial-susceptibility-of-klebsiella-pneumoniae-from-community-settings-in-taiwan-a-trend-analysis
#19
Wu-Pu Lin, Jann-Tay Wang, Shan-Chwen Chang, Feng-Yee Chang, Chang-Phone Fung, Yin-Ching Chuang, Yao-Shen Chen, Yih-Ru Shiau, Mei-Chen Tan, Hui-Ying Wang, Jui-Fen Lai, I-Wen Huang, Tsai-Ling Lauderdale
Drug-resistant Klebsiella pneumoniae, especially extended-spectrum β-lactamase (ESBL)- and/or AmpC β-lactamase-producing strains, is an emerging problem worldwide. However, few data focusing on drug susceptibility of K. pneumoniae from community is available. In this study, we analyzed 1016 K. pneumoniae isolates from outpatients or those visiting emergency rooms collected during 2002-2012 from Taiwan Surveillance of Antimicrobial Resistance program. Significantly decreased susceptibilities to 3(rd) generation cephalosporins and ciprofloxacin were found during the study period...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27803507/role-of-atypical-bacteria-in-hospitalized-patients-with-nursing-home-acquired-pneumonia
#20
Laura Meyer-Junco
Background: Nursing home-acquired pneumonia (NHAP) has been identified as one of the leading causes of mortality and hospitalization for long-term care residents. However, current and previous pneumonia guidelines differ on the appropriate management of NHAP in hospitalized patients, specifically in regard to the role of atypical bacteria such as Chlamydiae pneumonia, Mycoplasma pneumoniae, and Legionella. Objectives: The purpose of this review is to evaluate clinical trials conducted in hospitalized patients with NHAP to determine the prevalence of atypical bacteria and thus the role for empiric antibiotic coverage of these pathogens in NHAP...
October 2016: Hospital Pharmacy
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