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Nathan H J Bittner, Peter F Orio, Gregory S Merrick, Bradley R Prestidge, Alan Charles Hartford, Seth A Rosenthal
Transperineal permanent brachytherapy is a safe and effective treatment option for patients with organ-confined prostate cancer. Careful adherence to established brachytherapy standards has been shown to improve the likelihood of procedural success and reduce the incidence of treatment-related morbidity. A collaborative effort of the American College of Radiology (ACR) and the American Brachytherapy Society (ABS) has produced practice parameters for LDR prostate brachytherapy. These practice parameters define the qualifications and responsibilities of all the involved personnel, including the radiation oncologist, physicist and dosimetrist...
January 2017: Brachytherapy
Jing Zhang, Rohina Joshi, Jixin Sun, Samantha R Rosenthal, Miao Tong, Cong Li, Rasika Rampatige, Meghan Mooney, Alan Lopez, Lijing L Yan
BACKGROUND: Currently there are two main sources of mortality data with cause of death assignments in China. Both sources-the Ministry of Health-Vital Registration system and the Chinese Disease Surveillance Point system-present their own challenges. A new approach to cause of death assignment is a smartphone-based shortened version of a verbal autopsy survey. This study evaluates the feasibility and acceptability of this new method conducted by township health care providers (THP) and village doctors (VD) in rural China, where a large proportion of deaths occur in homes and cause of death data are inaccurate or lacking...
August 20, 2016: Population Health Metrics
Saeed Shoar, Alan A Saber, Mohammaed Aladdin, Moataz M Bashah, Mohammed J AlKuwari, Mohamed Rizwan, Raul J Rosenthal
BACKGROUND: Gastric artery embolization (GAE) has recently received attention as a minimally invasive intervention in bariatric setting. AIMS: The current systematic review aimed to gather and categorizes the existing data in the literature regarding bariatric gastric artery manipulation. This will highlight the importance of this potential concept as a therapeutic modality. METHODS: A PubMed/Medline search was conducted to identify animal and human studies investigating the effect of gastric artery manipulation on weight, ghrelin, obesity, and tissue adiposity...
December 2016: International Journal of Surgery
Jing Zhang, Rohina Joshi, Jixin Sun, Samantha R Rosenthal, Miao Tong, Cong Li, Rasika Rampatige, Meghan Mooney, Alan Lopez, Lijing L Yan
BACKGROUND: Currently there are two main sources of mortality data with cause of death assignments in China. Both sources-the Ministry of Health-Vital Registration system and the Chinese Disease Surveillance Point system-present their own challenges. A new approach to cause of death assignment is a smartphone-based shortened version of a verbal autopsy survey. This study evaluates the feasibility and acceptability of this new method conducted by township health care providers (THP) and village doctors (VD) in rural China, where a large proportion of deaths occur in homes and cause of death data are inaccurate or lacking...
2016: Population Health Metrics
Alan A Saber, Saeed Shoar, Mahmoud W Almadani, Natan Zundel, Mohammed J Alkuwari, Moataz M Bashah, Raul J Rosenthal
BACKGROUND: The intragastric balloon (IGB) is an adjunctive treatment for obesity. This meta-analysis aimed to evaluate the efficacy and safety of IGB treatment by reviewing randomized controlled trials (RCTs). METHODS: A total of 20 RCTs involving 1195 patients were identified. Weight loss results before and after 3 months were analyzed separately. The weight loss results of patients with and without IGB treatment were compared. RESULTS: Our meta-analysis calculated the following significant effect sizes: 1...
February 2017: Obesity Surgery
R Rosenthal, D Günzel, S M Krug, J-D Schulzke, M Fromm, A S L Yu
AIM: Claudin-2 is a tight junction protein typically located in 'leaky' epithelia exhibiting large paracellular permeabilities like small intestine and proximal kidney tubule. Former studies revealed that claudin-2 forms paracellular channels for small cations like sodium and potassium and also paracellular channels for water. This study analyses whether the diffusive transport of sodium and water occurs through a common pore of the claudin-2 channel. METHODS: Wild-type claudin-2 and different claudin-2 mutants were expressed in MDCK I kidney tubule cells using an inducible system...
February 2017: Acta Physiologica
Frederick A Jakobiec, Aristomenis Thanos, Anna M Stagner, Hans E Grossniklaus, Alan D Proia
Massive retinal gliosis, a nonneoplastic retinal glial proliferation, was first described in detail over 25 years ago, before the era of immunohistochemistry, in a series of 38 cases-to which can be added 30 case reports or small series (no more than 3 cases) subsequently. We analyze a new series of 3 nontumoral intraretinal glioses and 15 cases of tumoral retinal gliosis, not all of which, strictly speaking, were massive. The data from this series are compared with the findings in previously published cases...
May 2016: Survey of Ophthalmology
Jacob W Skovira, Shruti V Kabadi, Junfang Wu, Zaorui Zhao, Joseph DuBose, Robert Rosenthal, Gary Fiskum, Alan I Faden
Aeromedical evacuation, an important component in the care of many patients with traumatic brain injury (TBI), particularly in war zones, exposes them to prolonged periods of hypobaria. The effects of such exposure on pathophysiological changes and outcome after TBI are largely unexplored. The objective of this study was to investigate whether prolonged hypobaria in rats subjected to TBI alters behavioral and histological outcomes. Adult male Sprague-Dawley rats underwent fluid percussion induced injury at 1...
July 15, 2016: Journal of Neurotrauma
Danica A Helb, Kevin K A Tetteh, Philip L Felgner, Jeff Skinner, Alan Hubbard, Emmanuel Arinaitwe, Harriet Mayanja-Kizza, Isaac Ssewanyana, Moses R Kamya, James G Beeson, Jordan Tappero, David L Smith, Peter D Crompton, Philip J Rosenthal, Grant Dorsey, Christopher J Drakeley, Bryan Greenhouse
Tools to reliably measure Plasmodium falciparum (Pf) exposure in individuals and communities are needed to guide and evaluate malaria control interventions. Serologic assays can potentially produce precise exposure estimates at low cost; however, current approaches based on responses to a few characterized antigens are not designed to estimate exposure in individuals. Pf-specific antibody responses differ by antigen, suggesting that selection of antigens with defined kinetic profiles will improve estimates of Pf exposure...
August 11, 2015: Proceedings of the National Academy of Sciences of the United States of America
Seth A Rosenthal, Daniel Hunt, A Oliver Sartor, Kenneth J Pienta, Leonard Gomella, David Grignon, Raghu Rajan, Kevin J Kerlin, Christopher U Jones, Michael Dobelbower, William U Shipley, Kenneth Zeitzer, Daniel A Hamstra, Viroon Donavanik, Marvin Rotman, Alan C Hartford, Jeffrey Michalski, Michael Seider, Harold Kim, Deborah A Kuban, Jennifer Moughan, Howard Sandler
PURPOSE: Long-term (LT) androgen suppression (AS) with radiation therapy (RT) is a standard treatment of high-risk, localized prostate cancer (PCa). Radiation Therapy Oncology Group 9902 was a randomized trial testing the hypothesis that adjuvant combination chemotherapy (CT) with paclitaxel, estramustine, and oral etoposide plus LT AS plus RT would improve overall survival (OS). METHODS AND MATERIALS: Patients with high-risk PCa (prostate-specific antigen 20-100 ng/mL and Gleason score [GS] ≥ 7 or clinical stage ≥ T2 and GS ≥ 8) were randomized to RT and AS (AS + RT) alone or with adjuvant CT (AS + RT + CT)...
October 1, 2015: International Journal of Radiation Oncology, Biology, Physics
Alan Riley, Craig Sable, Aparna Prasad, Christopher Spurney, Ashraf Harahsheh, Sarah Clauss, Jessica Colyer, Marcin Gierdalski, Ashley Johnson, Gail D Pearson, Joanna Rosenthal
Adult patient series have shown hand-held echocardiography (echo) units (HHE) to be accurate for rapid diagnosis and triage. This is the first study to evaluate the ability of HHE to inform decision making in outpatient pediatric cardiology. New pediatric cardiology patients in outpatient clinics staffed by six pediatric cardiologists (experience 1-17 years) were prospectively enrolled if an echocardiogram (echo) was ordered during their initial visit. After history and physical examination and before a standard echo, the cardiologists performed a bedside HHE examination (GE Vscan 1...
December 2014: Pediatric Cardiology
Kay Denise Spong Lozano, C Matthew Hawkins, Seth A Rosenthal, Alan H Matsumoto, L D Ma, Kimberly E Applegate
The open-microphone sessions at the AMCLC provide a forum for the ACR's membership to be heard. The topics in 2013 included a review of the annual radiology workforce survey, the impact of teleradiology services, and the rationale for the new Imaging 3.0 initiative. Comments from members at the 2013 AMCLC unequivocally illustrated a single overarching theme: anxiety-anxiety about the future of our practices and anxiety about our profession. In light of recent and anticipated changes in health care, radiologists, radiation oncologists, interventional radiologists, nuclear medicine physicians, and medical physicists-members of the ACR-must continue to establish a leadership role in the health care system and serve as a cornerstone for all patient-care delivery models...
April 2014: Journal of the American College of Radiology: JACR
Alan Howard, Pintip Chitphakdithai, Edmund K Waller, Wayne Harris, Hilary Rosenthal, Wanda Nelson, Navneet Majhail, Willis Navarro, Stephanie Waldvogel, Joel Lisy, Jeff Uecker, John Miller, Stephen R Spellman
BACKGROUND: Peripheral blood stem cell (PBSC) products have traditionally been transported from the collection center to a transplant center using validated volunteer courier-based procedures. Evolving airline service strategies and security policies have complicated this model of product transport. This study was designed to evaluate the feasibility of transporting PBSC products using commercial overnight shipping services, while maintaining product quality, compared to courier-transported products...
June 2014: Transfusion
Xenofon Papanikolaou, Jackie Szymonifka, Adam Rosenthal, Christoph J Heuck, Alan Mitchell, Donald Johann, Jason Keller, Sarah Waheed, Saad Z Usmani, Frits Van Rhee, Clyde Bailey, Nathan Petty, Antje Hoering, John Crowley, Bart Barlogie
Relapsed/refractory multiple myeloma represents a major challenge in multiple myeloma therapy. For patients with relapsed/refractory multiple myeloma, we developed a treatment schema of metronomically scheduled drug therapy. We identified 186 patients who had been treated with metronomic therapy between March 2004 and January 2012 with a median follow up of 24.2 months. Median age was 61 years (range 36-83). Median number of prior therapies was 14 (range 1-51). Median number of completed metronomic therapy cycles was 1 (range 1-5), while 45 of 186 (25%) received 2 or more cycles...
July 2013: Haematologica
Steven K Seung, David A Larson, James M Galvin, Minesh P Mehta, Louis Potters, Christopher J Schultz, Santosh V Yajnik, Alan C Hartford, Seth A Rosenthal
American College of Radiology and American Society for Radiation Oncology Practice Guideline for the Performance of Stereotactic Radiosurgery (SRS). SRS is a safe and efficacious treatment option of a variety of benign and malignant disorders involving intracranial structures and selected extracranial lesions. SRS involves a high dose of ionizing radiation with a high degree of precision and spatial accuracy. A quality SRS program requires a multidisciplinary team involved in the patient management. Organization, appropriate staffing, and careful adherence to detail and to established SRS standards is important to ensure operational efficiency and to improve the likelihood of procedural success...
June 2013: American Journal of Clinical Oncology
Kenneth D R Setchell, James E Heubi, Sohela Shah, Joel E Lavine, David Suskind, Mohammed Al-Edreesi, Carol Potter, David W Russell, Nancy C O'Connell, Brian Wolfe, Pinky Jha, Wujuan Zhang, Kevin E Bove, Alex S Knisely, Alan F Hofmann, Philip Rosenthal, Laura N Bull
BACKGROUND & AIMS: The final step in bile acid synthesis involves conjugation with glycine and taurine, which promotes a high intraluminal micellar concentration to facilitate lipid absorption. We investigated the clinical, biochemical, molecular, and morphologic features of a genetic defect in bile acid conjugation in 10 pediatric patients with fat-soluble vitamin deficiency, some with growth failure or transient neonatal cholestatic hepatitis. METHODS: We identified the genetic defect that causes this disorder using mass spectrometry analysis of urine, bile, and serum samples and sequence analysis of the genes encoding bile acid-CoA:amino acid N-acyltransferase (BAAT) and bile acid-CoA ligase (SLC27A5)...
May 2013: Gastroenterology
Alan H Matsumoto, Mark J Adams, Jacqueline A Bello, Kay D Lozano, L D Ma, Seth A Rosenthal, Timothy L Swan
No abstract text is available yet for this article.
February 2013: Journal of the American College of Radiology: JACR
Ardan Patwardhan, José-Maria Carazo, Bridget Carragher, Richard Henderson, J Bernard Heymann, Emma Hill, Grant J Jensen, Ingvar Lagerstedt, Catherine L Lawson, Steven J Ludtke, David Mastronarde, William J Moore, Alan Roseman, Peter Rosenthal, Carlos-Oscar S Sorzano, Eduardo Sanz-García, Sjors H W Scheres, Sriram Subramaniam, John Westbrook, Martyn Winn, Jason R Swedlow, Gerard J Kleywegt
No abstract text is available yet for this article.
December 2012: Nature Structural & Molecular Biology
George W Bates, David M Rosenthal, Jindong Sun, Maitreyi Chattopadhyay, Emily Peffer, Jing Yang, Donald R Ort, Alan M Jones
Microarray analysis was performed on RNA isolated from guard cells that were manually dissected from leaves of Arabidopsis. By pooling our data with those of two earlier studies on Arabidopsis guard cell protoplasts, we provide a robust view of the guard-cell transcriptome, which is rich in transcripts for transcription factors, signaling proteins, transporters, and carbohydrate-modifying enzymes. To test the hypothesis that photosynthesis-derived sugar signals guard cells to adjust stomatal opening, we determined the profile of genes expressed in guard cells from leaves that had been treated with sucrose...
2012: PloS One
Alan C Hartford, James M Galvin, David C Beyer, Thomas J Eichler, Geoffrey S Ibbott, Brian Kavanagh, Christopher J Schultz, Seth A Rosenthal
Intensity-modulated radiation therapy (IMRT) is a complex technique for the delivery of radiation therapy preferentially to target structures while minimizing doses to adjacent normal critical structures. It is widely utilized in the treatment of a variety of clinical indications in radiation oncology, including tumors of the central nervous system, head and neck, breast, prostate, gastrointestinal tract, and gynecologic organs, as well as in situations where previous radiation therapy has been delivered, and has allowed for significant therapeutic advances in many clinical areas...
December 2012: American Journal of Clinical Oncology
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