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Alan rosenthal

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https://www.readbyqxmd.com/read/29759500/antibacterial-envelope-is-associated-with-low-infection-rates-after-implantable-cardioverter-defibrillator-and-cardiac-resynchronization-therapy-device-replacement-results-of-the-citadel-and-centurion-studies
#1
Charles A Henrikson, M Rizwan Sohail, Helbert Acosta, Eric E Johnson, Lawrence Rosenthal, Roman Pachulski, Dan Dan, Walter Paladino, Farhat S Khairallah, Kent Gleed, Ibrahim Hanna, Alan Cheng, Daniel R Lexcen, Grant R Simons
OBJECTIVES: This study sought to determine whether the nonabsorbable TYRX Antibacterial Envelope (TYRX) reduces major cardiovascular implantable electronic device (CIED) infections 12 months after implant. BACKGROUND: TYRX is a monofilament polypropylene mesh impregnated with minocycline and rifampin specifically designed to hold a CIED in place and elute antimicrobials over time. There are limited data on its ability to reduce CIED infections. METHODS: We prospectively enrolled patients who underwent generator replacement with an implantable cardioverter-defibrillator (ICD) or cardiac resynchronization therapy device (CRT), treated with TYRX...
October 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29668072/a-unique-telomere-dna-expansion-phenotype-in-human-retinal-rod-photoreceptors-associated-with-aging-and-disease
#2
W Robert Bell, Alan K Meeker, Anthony Rizzo, Sumit Rajpara, Ian M Rosenthal, Miguel Flores Bellver, Silvia Aparicio Domingo, Xiufeng Zhong, John R Barber, Corinne E Joshu, M Valeria Canto-Soler, Charles G Eberhart, Christopher M Heaphy
We have identified a discrete, focal telomere DNA expansion phenotype in the photoreceptor cell layer of normal, non-neoplastic human retinas. This phenotype is similar to that observed in a subset of human cancers, including a large fraction of tumors of the central nervous system, which maintain their telomeres via the non-telomerase-mediated alternative lengthening of telomeres (ALT) mechanism. We observed that these large, ultra-bright telomere DNA foci are restricted to the rod photoreceptors and are not observed in other cell types...
April 18, 2018: Brain Pathology
https://www.readbyqxmd.com/read/29661561/clinically-actionable-hypercholesterolemia-and-hypertriglyceridemia-in-children-with-nonalcoholic-fatty-liver-disease
#3
Kathryn E Harlow, Jonathan A Africa, Alan Wells, Patricia H Belt, Cynthia A Behling, Ajay K Jain, Jean P Molleston, Kimberly P Newton, Philip Rosenthal, Miriam B Vos, Stavra A Xanthakos, Joel E Lavine, Jeffrey B Schwimmer
OBJECTIVE: To determine the percentage of children with nonalcoholic fatty liver disease (NAFLD) in whom intervention for low-density lipoprotein cholesterol or triglycerides was indicated based on National Heart, Lung, and Blood Institute guidelines. STUDY DESIGN: This multicenter, longitudinal cohort study included children with NAFLD enrolled in the National Institute of Diabetes and Digestive and Kidney Diseases Nonalcoholic Steatohepatitis Clinical Research Network...
April 13, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29438655/short-term-neurodevelopmental-outcome-in-children-born-with-high-risk-congenital-lung-lesions
#4
Enrico Danzer, Casey Hoffman, Jo Ann D'Agostino, Matthew M Boelig, Marsha Gerdes, Judy C Bernbaum, Hannah Rosenthal, Lindsay N Waqar, Natalie E Rintoul, Lisa M Herkert, Michael J Kallan, William H Peranteau, Alan W Flake, N Scott Adzick, Holly L Hedrick
BACKGROUND: This study sought to evaluate neurodevelopmental outcome in survivors of high-risk congenital lung lesions (CLLs) who underwent prenatal intervention or postnatal surgery within the first month of life. METHODS: Forty-five high-risk CLL survivors underwent assessment using the Bayley Scales of Infant Development, 3rd Edition between July 2004 and December 2016. Scores were grouped as average, at-risk, and delayed based on SD intervals. Correlations between outcome and risk factors were analyzed by Fisher's exact test or two-sided t test as appropriate, with significant p values <0...
February 10, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29426392/effects-of-lighting-on-reading-speed-as-a-function-of-letter-size
#5
William Seiple, Olga Overbury, Bruce Rosenthal, Tiffany Arango, J Vernon Odom, Alan R Morse
OBJECTIVE: We sought to determine under what conditions brighter lighting improves reading performance. METHOD: Thirteen participants with typical sight and 9 participants with age-related macular degeneration (AMD) read sentences ranging from 0.0 to 1.3 logMAR under luminance levels ranging from 3.5 to 696 cd/m². RESULTS: At the dimmest luminance level (3.5 cd/m²), reading speeds were slowest at the smaller letter sizes and reached an asymptote for larger sizes...
March 2018: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/29383650/rate-and-risk-factors-associated-with-autism-spectrum-disorder-in-congenital-diaphragmatic-hernia
#6
Enrico Danzer, Casey Hoffman, Jo Ann D'Agostino, Judith S Miller, Lindsay N Waqar, Marsha Gerdes, Judy C Bernbaum, Hannah Rosenthal, Natalie E Rintoul, Lisa M Herkert, William H Peranteau, Alan W Flake, N Scott Adzick, Holly L Hedrick
To determine the rate and predictors of autism spectrum disorder (ASD) in congenital diaphragmatic hernia (CDH). Between 06/2004 and 09/2015 a total of 110 CDH survivors underwent neurodevelopmental (ND) testing and screening for ASD, followed by a full autism diagnostic evaluation if indicated at our institution. We found a 9 time higher rate of ASD in CDH children compared to the general population (P = 0.0002). Multiple patient-related and clinical variables risk factors of ASD were identified by univariate analysis...
January 30, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29208020/mapping-upper-limb-motor-performance-after-stroke-a-novel-method-with-utility-for-individualized-motor-training
#7
Orna Rosenthal, Alan M Wing, Jeremy L Wyatt, David Punt, R Chris Miall
BACKGROUND: Chronic upper limb motor impairment is a common outcome of stroke. Therapeutic training can reduce motor impairment. Recently, a growing interest in evaluating motor training provided by robotic assistive devices has emerged. Robot-assisted therapy is attractive because it provides a means of increasing practice intensity without increasing the workload of physical therapists. However, movements practised through robotic assistive devices are commonly pre-defined and fixed across individuals...
December 6, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29127578/comparative-outcomes-of-bariatric-surgery-in-patients-with-and-without-human-immunodeficiency-virus
#8
Gautam Sharma, Andrew T Strong, Mena Boules, Chao Tu, Samuel Szomstein, Raul Rosenthal, John Rodriguez, Alan J Taege, Matthew Kroh
BACKGROUND: Paradoxically, advances in anti-retroviral therapy that has increased survival for patients with human immunodeficiency virus (HIV) have resulted in greater numbers of HIV+ patients developing other chronic diseases, including obesity. Little comparative literature exists detailing perioperative or metabolic outcomes of bariatric surgery in the HIV+ population compared to HIV negative (HIV-) controls. METHODS: This is a retrospective case-control study with both HIV+ (case) and HIV- control patients...
April 2018: Obesity Surgery
https://www.readbyqxmd.com/read/28988661/american-college-of-radiology-american-brachytherapy-society-practice-parameter-for-electronically-generated-low-energy-radiation-sources
#9
Phillip M Devlin, Laurie E Gaspar, Ivan Buzurovic, D Jeffrey Demanes, Michael E Kasper, Subir Nag, Zoubir Ouhib, Joshua H Petit, Seth A Rosenthal, William Small, Paul E Wallner, Alan C Hartford
BACKGROUND: This collaborative practice parameter technical standard has been created between the American College of Radiology and American Brachytherapy Society to guide the usage of electronically generated low energy radiation sources (ELSs). It refers to the use of electronic X-ray sources with peak voltages up to 120 kVp to deliver therapeutic radiation therapy. MAIN FINDINGS: The parameter provides a guideline for utilizing ELS, including patient selection and consent, treatment planning, and delivery processes...
November 2017: Brachytherapy
https://www.readbyqxmd.com/read/28434664/marine-debris-in-beaches-of-the-southwestern-atlantic-an-assessment-of-their-abundance-and-mass-at-different-spatial-scales-in-northern-coastal-argentina
#10
Maria Eugenia Becherucci, Alan Federico Rosenthal, Juan Pablo Seco Pon
Argentina is currently undergoing an intensive development of coastal-oriented tourism due to the temperate climate and coastal sceneries of the Southwestern Atlantic and particularly its wide ocean-open sandy beaches, which may turn into an important contributor of marine debris to the beaches. This study was designed to assess at four spatial scales (i) the variation of the abundance and mass of marine debris and (ii) the composition and sources of these items in sandy-tourist beaches of coastal zones of the province of Buenos Aires, in northern Argentina...
June 15, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28109632/the-american-college-of-radiology-and-the-american-brachytherapy-society-practice-parameter-for-transperineal-permanent-brachytherapy-of-prostate-cancer
#11
Nathan H J Bittner, Peter F Orio, Gregory S Merrick, Bradley R Prestidge, Alan Charles Hartford, Seth A Rosenthal
Transperineal permanent brachytherapy is a safe and effective treatment option for patients with organ-confined prostate cancer. Careful adherence to established brachytherapy standards has been shown to improve the likelihood of procedural success and reduce the incidence of treatment-related morbidity. A collaborative effort of the American College of Radiology (ACR) and the American Brachytherapy Society (ABS) has produced practice parameters for LDR prostate brachytherapy. These practice parameters define the qualifications and responsibilities of all the involved personnel, including the radiation oncologist, physicist and dosimetrist...
January 2017: Brachytherapy
https://www.readbyqxmd.com/read/27905970/a-feasibility-study-on-using-smartphones-to-conduct-short-version-verbal-autopsies-in-rural-china
#12
Jing Zhang, Rohina Joshi, Jixin Sun, Samantha R Rosenthal, Miao Tong, Cong Li, Rasika Rampatige, Meghan Mooney, Alan Lopez, Lijing L Yan
BACKGROUND: Currently there are two main sources of mortality data with cause of death assignments in China. Both sources-the Ministry of Health-Vital Registration system and the Chinese Disease Surveillance Point system-present their own challenges. A new approach to cause of death assignment is a smartphone-based shortened version of a verbal autopsy survey. This study evaluates the feasibility and acceptability of this new method conducted by township health care providers (THP) and village doctors (VD) in rural China, where a large proportion of deaths occur in homes and cause of death data are inaccurate or lacking...
August 20, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27751912/bariatric-manipulation-of-gastric-arteries-a-systematic-review-on-the%C3%A2-potential-concept-for-treatment-of-obesity
#13
REVIEW
Saeed Shoar, Alan A Saber, Mohammaed Aladdin, Moataz M Bashah, Mohammed J AlKuwari, Mohamed Rizwan, Raul J Rosenthal
BACKGROUND: Gastric artery embolization (GAE) has recently received attention as a minimally invasive intervention in bariatric setting. AIMS: The current systematic review aimed to gather and categorizes the existing data in the literature regarding bariatric gastric artery manipulation. This will highlight the importance of this potential concept as a therapeutic modality. METHODS: A PubMed/Medline search was conducted to identify animal and human studies investigating the effect of gastric artery manipulation on weight, ghrelin, obesity, and tissue adiposity...
December 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27547126/a-feasibility-study-on-using-smartphones-to-conduct-short-version-verbal-autopsies-in-rural-china
#14
Jing Zhang, Rohina Joshi, Jixin Sun, Samantha R Rosenthal, Miao Tong, Cong Li, Rasika Rampatige, Meghan Mooney, Alan Lopez, Lijing L Yan
BACKGROUND: Currently there are two main sources of mortality data with cause of death assignments in China. Both sources-the Ministry of Health-Vital Registration system and the Chinese Disease Surveillance Point system-present their own challenges. A new approach to cause of death assignment is a smartphone-based shortened version of a verbal autopsy survey. This study evaluates the feasibility and acceptability of this new method conducted by township health care providers (THP) and village doctors (VD) in rural China, where a large proportion of deaths occur in homes and cause of death data are inaccurate or lacking...
2016: Population Health Metrics
https://www.readbyqxmd.com/read/27465936/efficacy-of-first-time-intragastric-balloon-in-weight-loss-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#15
REVIEW
Alan A Saber, Saeed Shoar, Mahmoud W Almadani, Natan Zundel, Mohammed J Alkuwari, Moataz M Bashah, Raul J Rosenthal
BACKGROUND: The intragastric balloon (IGB) is an adjunctive treatment for obesity. This meta-analysis aimed to evaluate the efficacy and safety of IGB treatment by reviewing randomized controlled trials (RCTs). METHODS: A total of 20 RCTs involving 1195 patients were identified. Weight loss results before and after 3 months were analyzed separately. The weight loss results of patients with and without IGB treatment were compared. RESULTS: Our meta-analysis calculated the following significant effect sizes: 1...
February 2017: Obesity Surgery
https://www.readbyqxmd.com/read/27359349/claudin-2-mediated-cation-and-water-transport-share-a-common-pore
#16
R Rosenthal, D Günzel, S M Krug, J-D Schulzke, M Fromm, A S L Yu
AIM: Claudin-2 is a tight junction protein typically located in 'leaky' epithelia exhibiting large paracellular permeabilities like small intestine and proximal kidney tubule. Former studies revealed that claudin-2 forms paracellular channels for small cations like sodium and potassium and also paracellular channels for water. This study analyses whether the diffusive transport of sodium and water occurs through a common pore of the claudin-2 channel. METHODS: Wild-type claudin-2 and different claudin-2 mutants were expressed in MDCK I kidney tubule cells using an inducible system...
February 2017: Acta Physiologica
https://www.readbyqxmd.com/read/26703887/so-called-massive-retinal-gliosis-a-critical-review-and-reappraisal
#17
REVIEW
Frederick A Jakobiec, Aristomenis Thanos, Anna M Stagner, Hans E Grossniklaus, Alan D Proia
Massive retinal gliosis, a nonneoplastic retinal glial proliferation, was first described in detail over 25 years ago, before the era of immunohistochemistry, in a series of 38 cases-to which can be added 30 case reports or small series (no more than 3 cases) subsequently. We analyze a new series of 3 nontumoral intraretinal glioses and 15 cases of tumoral retinal gliosis, not all of which, strictly speaking, were massive. The data from this series are compared with the findings in previously published cases...
May 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/26593382/simulated-aeromedical-evacuation-exacerbates-experimental-brain-injury
#18
Jacob W Skovira, Shruti V Kabadi, Junfang Wu, Zaorui Zhao, Joseph DuBose, Robert Rosenthal, Gary Fiskum, Alan I Faden
Aeromedical evacuation, an important component in the care of many patients with traumatic brain injury (TBI), particularly in war zones, exposes them to prolonged periods of hypobaria. The effects of such exposure on pathophysiological changes and outcome after TBI are largely unexplored. The objective of this study was to investigate whether prolonged hypobaria in rats subjected to TBI alters behavioral and histological outcomes. Adult male Sprague-Dawley rats underwent fluid percussion induced injury at 1...
July 15, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/26216993/novel-serologic-biomarkers-provide-accurate-estimates-of-recent-plasmodium-falciparum-exposure-for-individuals-and-communities
#19
Danica A Helb, Kevin K A Tetteh, Philip L Felgner, Jeff Skinner, Alan Hubbard, Emmanuel Arinaitwe, Harriet Mayanja-Kizza, Isaac Ssewanyana, Moses R Kamya, James G Beeson, Jordan Tappero, David L Smith, Peter D Crompton, Philip J Rosenthal, Grant Dorsey, Christopher J Drakeley, Bryan Greenhouse
Tools to reliably measure Plasmodium falciparum (Pf) exposure in individuals and communities are needed to guide and evaluate malaria control interventions. Serologic assays can potentially produce precise exposure estimates at low cost; however, current approaches based on responses to a few characterized antigens are not designed to estimate exposure in individuals. Pf-specific antibody responses differ by antigen, suggesting that selection of antigens with defined kinetic profiles will improve estimates of Pf exposure...
August 11, 2015: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/26209502/a-phase-3-trial-of-2-years-of-androgen-suppression-and-radiation-therapy-with-or-without-adjuvant-chemotherapy-for-high-risk-prostate-cancer-final-results-of-radiation-therapy-oncology-group-phase-3-randomized-trial-nrg-oncology-rtog-9902
#20
RANDOMIZED CONTROLLED TRIAL
Seth A Rosenthal, Daniel Hunt, A Oliver Sartor, Kenneth J Pienta, Leonard Gomella, David Grignon, Raghu Rajan, Kevin J Kerlin, Christopher U Jones, Michael Dobelbower, William U Shipley, Kenneth Zeitzer, Daniel A Hamstra, Viroon Donavanik, Marvin Rotman, Alan C Hartford, Jeffrey Michalski, Michael Seider, Harold Kim, Deborah A Kuban, Jennifer Moughan, Howard Sandler
PURPOSE: Long-term (LT) androgen suppression (AS) with radiation therapy (RT) is a standard treatment of high-risk, localized prostate cancer (PCa). Radiation Therapy Oncology Group 9902 was a randomized trial testing the hypothesis that adjuvant combination chemotherapy (CT) with paclitaxel, estramustine, and oral etoposide plus LT AS plus RT would improve overall survival (OS). METHODS AND MATERIALS: Patients with high-risk PCa (prostate-specific antigen 20-100 ng/mL and Gleason score [GS] ≥ 7 or clinical stage ≥ T2 and GS ≥ 8) were randomized to RT and AS (AS + RT) alone or with adjuvant CT (AS + RT + CT)...
October 1, 2015: International Journal of Radiation Oncology, Biology, Physics
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