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JOURNAL ARTICLE
Chelsey Baldwin, Jonathan D Newman, Franco Vallejo, Valerie Peck, Loren Wissner Greene, Ira J Goldberg
Context: Thyroid hormone plays a critical role in cardiovascular function. Severe hypothyroidism can be associated with "myxedema heart" characterized by relative bradycardia and pericardial effusion. Effusions associated with severe hypothyroidism can be large. Despite the large volume of effusions, tamponade is not a common consequence. However, with the incorporation of echocardiography into routine practice for evaluation of effusion, echocardiographic findings suggestive of clinical tamponade occur frequently...
January 1, 2021: Journal of the Endocrine Society
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JOURNAL ARTICLE
Irena Jacukowicz-Sobala, Ewa Stanisławska, Agnieszka Baszczuk, Marek Jasiorski, Elżbieta Kociołek-Balawejder
Composite materials containing zero valent copper (ZVC) dispersed in the matrix of two commercially available strongly basic anion exchangers with a macroreticular (Amberlite IRA 900Cl) and gel-like (Amberlite IRA 402OH) structure were obtained. Cu0 particles appeared in the resin phase as the product of the reduction of the precursor, i.e., copper oxide(I) particles previously deposited in the two supporting materials. As a result of a one-step transformation of preformed Cu2 O particles as templates conducted using green reductant ascorbic acid and under mild conditions, macroporous and gel-type hybrid products containing ZVC were obtained with a total copper content of 7...
November 9, 2020: Polymers
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JOURNAL ARTICLE
Carla Arnau Del Valle, Vanesa Pérez-Laguna, Ignacio Muñoz Resta, Raquel Gavara, Carles Felip-León, Juan F Miravet, Antonio Rezusta, Francisco Galindo
Two new photoactive materials have been prepared, characterized and tested against Pseudomonas aeruginosa bacteria (planktonic suspension). The synthesis of the polymeric photosensitizers can be made at a multigram scale, in few minutes, starting from inexpensive and readily available materials, such as Rose Bengal (photosensitizer) and ion exchange resins Amberlite® IRA 900 (macroporous) or IRA 400 (gel-type) as cationic polystyrene supports. The most notable feature of these systems is their notable bactericidal activity in the dark (4-5 log10 CFU/mL reduction of the population of P...
December 2020: Materials Science & Engineering. C, Materials for Biological Applications
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JOURNAL ARTICLE
Marisa C May, David C Pavone, Ira S Lurie
This study ascertained the viability of a portable liquid chromatograph, operating at low μL/min flow, for the analysis of seized drugs at remote sites as well as in laboratory settings. Synthetic cathinones were screened using dual capillary columns in series, C8 and biphenyl, with on-column ultraviolet detection at 255 nm and 275 nm. The relative retention times of the two columns in series and their peak area absorbance ratio were used to determine if the 16 synthetic cathinones investigated could be uniquely identified in these conditions...
August 3, 2020: Journal of Separation Science
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JOURNAL ARTICLE
Laura Green, Jahnavi Daru, Julie Dodds, Francisco Jose Gonzalez Carreras, Doris Lanz, Javier Zamora, Maria Del Carmen Pardo Llorente, Teresa Pérez Pérez, Lorna Sweeney, Shakila Thangaratinam, Amy Thomas, Khalid Saeed Khan
INTRODUCTION: The incidence of severe postpartum haemorrhage (PPH) that requires blood transfusion is on the increase. Fibrinogen levels have been shown to drop early and significantly during PPH, which is associated with worse outcomes. Early fibrinogen replacement could potentially improve outcomes. No studies have investigated the clinical impact of early cryoprecipitate transfusion in PPH. Prior to performing a full-scale trial, a pilot study is needed to determine feasibility of the intervention and recruitment...
June 21, 2020: BMJ Open
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JOURNAL ARTICLE
Yanqin Yang, Mingming Zhang, Jinjie Hua, Yuliang Deng, Yongwen Jiang, Jia Li, Jinjin Wang, Haibo Yuan, Chunwang Dong
Pyrazines play an important role in the characteristic flavor of roasted green tea due to powerful strong odours and low sensory thresholds. It is important to analyze these compounds reliably and rapidly in roasted green tea. In this study, infrared-assisted extraction coupled to headspace solid-phase microextraction (IRAE-HS-SPME) and gas chromatography-triple quadrupole-tandem mass spectrometry (GC-QqQ-MS/MS) were developed and validated to determine the pyrazines in roasted green tea. Good linear correlation coefficients (0...
August 2020: Food Research International
#27
JOURNAL ARTICLE
Wen-Qing Zhang, Killian Fleurial, Ira Sherr, Robert Vassov, Janusz J Zwiazek
Bitumen recovery from oil sands in northeastern Alberta, Canada produces large volumes of tailings, which are deposited in mining areas that must be reclaimed upon mine closure. A new technology of non-segregated tailings (NST) developed by Canadian Natural Resources Limited (CNRL) was designed to accelerate the process of oil sands fine tailings consolidation. However, effects of these novel tailings on plants used for the reclamation of oil sands mining areas remain to be determined. In the present study, we investigated the effects of NST on seedlings of three species of plants commonly planted in oil sands reclamation sites including paper birch (Betula papyrifera), white spruce (Picea glauca) and green alder (Alnus viridis)...
January 8, 2020: Environmental Pollution
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JOURNAL ARTICLE
Zhenxin Yan, Chaoyou Xue, Sandeep Kumar, J Brooks Crickard, Yang Yu, Weibin Wang, Nhung Pham, Yuxi Li, Hengyao Niu, Patrick Sung, Eric C Greene, Grzegorz Ira
Rad52 is a key factor for homologous recombination (HR) in yeast. Rad52 helps assemble Rad51-ssDNA nucleoprotein filaments that catalyze DNA strand exchange, and it mediates single-strand DNA annealing. We find that Rad52 has an even earlier function in HR in restricting DNA double-stranded break ends resection that generates 3' single-stranded DNA (ssDNA) tails. In fission yeast, Exo1 is the primary resection nuclease, with the helicase Rqh1 playing a minor role. We demonstrate that the choice of two extensive resection pathways is regulated by Rad52...
September 16, 2019: Molecular Cell
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MULTICENTER STUDY
Mark W Kieran, Birgit Geoerger, Ira J Dunkel, Alberto Broniscer, Darren Hargrave, Pooja Hingorani, Isabelle Aerts, Anne-Isabelle Bertozzi, Kenneth J Cohen, Trent R Hummel, Violet Shen, Eric Bouffet, Christine A Pratilas, Andrew D J Pearson, Lillian Tseng, Noelia Nebot, Steven Green, Mark W Russo, James A Whitlock
PURPOSE: The 2-part, phase I/IIa, open-label study (NCT01677741) sought to determine the safety, tolerability, pharmacokinetics, and preliminary activity of dabrafenib in pediatric patients with advanced BRAF V600-mutated cancers. PATIENTS AND METHODS: This phase I dose-finding part treated patients ages 1 to <18 years with BRAF V600 mutation-positive tumors with oral dabrafenib 3 to 5.25 mg/kg/day to determine the RP2D based on safety and drug exposure target...
December 15, 2019: Clinical Cancer Research
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REVIEW
Ira M Lubin, Edward R Lockhart, Julie Frank, Vincent Y See, Sudhir Vashist, Carol Greene
Background An increasing number of diagnostic evaluations incorporate genetic testing to facilitate accurate and timely diagnoses. The increasing number and complexity of genetic tests continue to pose challenges in deciding when to test, selecting the correct test(s), and using results to inform medical diagnoses, especially for medical professionals lacking genetic expertise. Careful consideration of a diagnostic workflow can be helpful in understanding the appropriate uses of genetic testing within a broader diagnostic workup...
July 9, 2019: Diagnosis
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JOURNAL ARTICLE
Lina Su, Yinghui Deng, Nianzu Chen, Xiuwen Zhang, Taomin Huang
BACKGROUND: Angoroside C, cinnamic acid, and harpagoside are bioactive constituents in Scrophularia ningpoensis. Currently, an infrared-assisted extraction (IRAE) method coupled with high-performance liquid chromatography with ultraviolet detection (HPLC-UV) for the analysis of bioactive constituents in this plant is lacking. METHODS: A method based on HPLC following IRAE has been developed for quantifying angoroside C, cinnamic acid, and harpagoside in Scrophularia ningpoensis...
June 14, 2019: BMC Complementary and Alternative Medicine
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JOURNAL ARTICLE
Junjun Quan, Zhongli Jia, Tiewei Lv, Lei Zhang, Lingjuan Liu, Bo Pan, Jing Zhu, Ira J Gelb, Xupei Huang, Jie Tian
BACKGROUND: Our previous studies have demonstrated that Ca2+ desensitizing catechin could correct diastolic dysfunction in experimental animals with restrictive cardiomyopathy. In this study, it is aimed to assess the effects of green tea extract catechin on cardiac function and other clinical features in pediatric patients with cardiomyopathies. METHODS: Twelve pediatric cardiomyopathy patients with diastolic dysfunction were enrolled for the study. Echocardiography, ECG, and laboratory tests were performed before and after the catechin administration for 12 months...
May 8, 2019: Journal of Biomedical Science
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JOURNAL ARTICLE
Lorena Fernandez-Mosquera, King Faisal Yambire, Renata Couto, Leonardo Pereyra, Kamil Pabis, Amy H Ponsford, Cátia V Diogo, Massimiliano Stagi, Ira Milosevic, Nuno Raimundo
Mitochondria are key organelles for cellular metabolism, and regulate several processes including cell death and macroautophagy/autophagy. Here, we show that mitochondrial respiratory chain (RC) deficiency deactivates AMP-activated protein kinase (AMPK, a key regulator of energy homeostasis) signaling in tissue and in cultured cells. The deactivation of AMPK in RC-deficiency is due to increased expression of the AMPK-inhibiting protein FLCN (folliculin). AMPK is found to be necessary for basal lysosomal function, and AMPK deactivation in RC-deficiency inhibits lysosomal function by decreasing the activity of the lysosomal Ca2+ channel MCOLN1 (mucolipin 1)...
September 2019: Autophagy
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JOURNAL ARTICLE
Brian J Thomas, Ira E Wight, Wendy Y Y Chou, Marco Moreno, Zachary Dawson, Arielle Homayouni, Huiyan Huang, Hyori Kim, Hanna Jia, Justin R Buland, Jennifer A Wambach, F Sessions Cole, Stephen C Pak, Gary A Silverman, Cliff J Luke
Due to its ease of genetic manipulation and transparency, Caenorhabditis elegans (C. elegans) has become a preferred model system to study gene function by microscopy. The use of Aequorea victoria green fluorescent protein (GFP) fused to proteins or targeting sequences of interest, further expanded upon the utility of C. elegans by labeling subcellular structures, which enables following their disposition during development or in the presence of genetic mutations. Fluorescent proteins with excitation and emission spectra different from that of GFP accelerated the use of multifluorophore imaging in real time...
2019: PloS One
#35
JOURNAL ARTICLE
Wadah Ibrahim, Michael Wilde, Rebecca Cordell, Dahlia Salman, Dorota Ruszkiewicz, Luke Bryant, Matthew Richardson, Robert C Free, Bo Zhao, Ahmed Yousuf, Christobelle White, Richard Russell, Sheila Jones, Bharti Patel, Asia Awal, Rachael Phillips, Graham Fowkes, Teresa McNally, Clare Foxon, Hetan Bhatt, Rosa Peltrini, Amisha Singapuri, Beverley Hargadon, Toru Suzuki, Leong L Ng, Erol Gaillard, Caroline Beardsmore, Kimuli Ryanna, Hitesh Pandya, Tim Coates, Paul S Monks, Neil Greening, Christopher E Brightling, Paul Thomas, Salman Siddiqui
INTRODUCTION: Patients presenting with acute undifferentiated breathlessness are commonly encountered in admissions units across the UK. Existing blood biomarkers have clinical utility in distinguishing patients with single organ pathologies but have poor discriminatory power in multifactorial presentations. Evaluation of volatile organic compounds (VOCs) in exhaled breath offers the potential to develop biomarkers of disease states that underpin acute cardiorespiratory breathlessness, owing to their proximity to the cardiorespiratory system...
March 8, 2019: BMJ Open
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JOURNAL ARTICLE
Tsair-Wei Chien, Hsien-Yi Wang, Yu Chang, Wei-Chih Kan
Schizophrenia is a severe mental disorder affecting more than 21 million people worldwide. Scientific collaborations are required to research schizophrenia. However, there have been limited publications to date investigating scientific collaborations in schizophrenia research or reporting individual researchers' achievements(IRA) for authors. This study aimed to investigate the pattern of coauthor collaborations in schizophrenia research. We conducted a bibliometric study of international scientific publications on schizophrenia...
September 24, 2018: Schizophrenia Research
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JOURNAL ARTICLE
Daniela Nürnberg, Ira Seibel, Aline Isabel Riechardt, Claudia Brockmann, Oliver Zeitz, Jens Heufelder, Antonia M Joussen
Imaging of intraocular tumors is multimodal, multi-purpose, and in continuous development. Therefore, imaging is indispensable for the detection, diagnosis, therapy and monitoring of intraocular tumours. A broad spectrum of imaging procedures is available for diagnostic testing and follow-up. This includes colour image acquisition, infrared imaging, autofluorescence imaging, fluorescence and indocyanine green angiography, optical coherence tomography (OCT) and sonography (US). In this article, the various investigations and their benefits are described using individual examples for the differential diagnosis of choroidal melanoma and retinal vascular tumours located in the fundus periphery...
September 2018: Klinische Monatsblätter Für Augenheilkunde
#38
JOURNAL ARTICLE
Ira Seibel, Daniela Nürnberg, Julia Löwen, Sibylle Winterhalter, Oliver Zeitz, Antonia M Joussen
PEHCR (peripheral exudative haemorrhagic chorioretinopathy) is a disease manifested clinically, particularly by subretinal bleeding, retinal exudates, retinal pigment epithelium detachments (RPE detachments), exudative retinal detachment and sub-RPE bleeding. The PEHCR lesion is often characterized by its polypoidal pattern, which is very similar to PCV (polypoidal choroidal vasculopathy) polyps. Diagnosis is best made with a wide-field ICGA (indocyanine green angiography). In approximately half of patients, macular changes in the form of drusen, up to exudative AMD (age-related macular degeneration), are detected in the affected eye or partner eye...
September 2018: Klinische Monatsblätter Für Augenheilkunde
#39
JOURNAL ARTICLE
Claire Butler, Charlotte Brigden, Heather Gage, Peter Williams, Laura Holdsworth, Kay Greene, Bee Wee, Stephen Barclay, Patricia Wilson
INTRODUCTION: Hospice at home (HAH) services aim to enable patients to be cared for and die in their place of choice, if that is at home, and to achieve a 'good death'. There is a considerable range of HAH services operating in England. The published evidence focuses on evaluations of individual services which vary considerably, and there is a lack of consistency in terms of the outcome measures reported. The evidence, therefore, does not provide generalisable information, so the question 'What are the features of hospice at home service models that work, for whom, and under what circumstances?' remains unanswered...
May 16, 2018: BMJ Open
#40
JOURNAL ARTICLE
Rafiq Islam, Chad Briscoe, Joseph Bower, Stephanie Cape, Mark Arnold, Roger Hayes, Mark Warren, Shane Karnik, Bruce Stouffer, Yi Qun Xiao, Barry van der Strate, Daniel Sikkema, Xinping Fang, Ariana Tudoroniu, Rabab Tayyem, Ashley Brant, Franklin Spriggs, Colin Barry, Masood Khan, Anahita Keyhani, Jennifer Zimmer, Maria Cruz Caturla, Philippe Couerbe, Ardeshir Khadang, James Bourdage, Jim Datin, Jennifer Zemo, Nicola Hughes, Saadya Fatmi, Curtis Sheldon, Scott Fountain, Christina Satterwhite, Kelly Colletti, Jenifer Vija, Mathilde Yu, John Stamatopoulos, Jenny Lin, Jim Wilfahrt, Andrew Dinan, Susan Ohorodnik, James Hulse, Vimal Patel, Wei Garofolo, Natasha Savoie, Michael Brown, Damon Papac, Mike Buonarati, George Hristopoulos, Chris Beaver, Nadine Boudreau, Clark Williard, Yansheng Liu, Gene Ray, Dominic Warrino, Allan Xu, Rachel Green, Joanne Hayward-Sewell, John Marcelletti, Christina Sanchez, Michael Kennedy, Jessica St Charles, Mohammed Bouhajib, Corey Nehls, Edward Tabler, Jing Tu, Philip Joyce, Adriana Iordachescu, Ira DuBey, John Lindsay, Jim Yamashita, Edward Wells
The 11th Global CRO Council Closed Forum was held in Universal City, CA, USA on 3 April 2017. Representatives from international CRO members offering bioanalytical services were in attendance in order to discuss scientific and regulatory issues specific to bioanalysis. The second CRO-Pharma Scientific Interchange Meeting was held on 7 April 2017, which included Pharma representatives' sharing perspectives on the topics discussed earlier in the week with the CRO members. The issues discussed at the meetings included cumulative stability evaluations, matrix stability evaluations, the 2016 US FDA Immunogenicity Guidance and recent and unexpected FDA Form 483s on immunogenicity assays, the bioanalytical laboratory's role in writing PK sample collection instructions, biosimilars, CRO perspectives on the use of chiral versus achiral methods, hybrid LBA/LCMS assays, applications of fit-for-purpose validation and, at the Global CRO Council Closed Forum only, the status and trend of current regulated bioanalytical practice in China under CFDA's new BMV policy...
April 1, 2018: Bioanalysis
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