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https://www.readbyqxmd.com/read/28944752/a-randomised-controlled-study-of-the-effectiveness-of-breathing-retraining-exercises-taught-by-a-physiotherapist-either-by-instructional-dvd-or-in-face-to-face-sessions-in-the-management-of-asthma-in-adults
#1
Mike Thomas, Anne Bruton, Paul Little, Stephen Holgate, Amanda Lee, Lucy Yardley, Steve George, James Raftery, Jennifer Versnel, David Price, Ian Pavord, Ratko Djukanovic, Michael Moore, Sarah Kirby, Guiqing Yao, Shihua Zhu, Emily Arden-Close, Manimekalai Thiruvothiyur, Frances Webley, Mark Stafford-Watson, Elizabeth Dixon, Lynda Taylor
BACKGROUND: Asthma control is suboptimal, resulting in quality of life (QoL) impairment and costs. Breathing retraining exercises have evidence of effectiveness as adjuvant treatment, but are infrequently used. OBJECTIVES: To transfer the contents of a brief (three-session) physiotherapist-delivered breathing retraining programme to a digital versatile disc (DVD) and booklet format; to compare the effectiveness of the self-guided intervention with that of 'face-to-face' physiotherapy and usual care for QoL and other asthma-related outcomes; to perform a health economic assessment of both interventions; and to perform a process evaluation using quantitative and qualitative methods...
September 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28944555/biological-hierarchies-and-the-nature-of-extinction
#2
Curtis R Congreve, Amanda R Falk, James C Lamsdell
Hierarchy theory recognises that ecological and evolutionary units occur in a nested and interconnected hierarchical system, with cascading effects occurring between hierarchical levels. Different biological disciplines have routinely come into conflict over the primacy of different forcing mechanisms behind evolutionary and ecological change. These disconnects arise partly from differences in perspective (with some researchers favouring ecological forcing mechanisms while others favour developmental/historical mechanisms), as well as differences in the temporal framework in which workers operate...
September 24, 2017: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/28944516/innovation-or-violation-leveraging-mobile-technology-to-conduct-socially-responsible-community-research
#3
Amanda L Roy
Mobile technology is increasingly being used to measure individuals' moods, thoughts, and behaviors in real time. Current examples include the use of smartphones to collect ecological momentary assessments (EMAs; assessments delivered "in the moment"); wearable technology to passively collect objective measures of participants' movement, physical activity, sleep, and physiological response; and smartphones and wearable devices with global positioning system (GPS) capabilities to collect precise information about where participants spend their time...
September 25, 2017: American Journal of Community Psychology
https://www.readbyqxmd.com/read/28944475/the-effect-of-consumer-pressure-and-abiotic-stress-on-positive-plant-interactions-are-mediated-by-extreme-climatic-events
#4
Alessandro Filazzola, Amanda Rae Liczner, Michael Westphal, Christopher J Lortie
Environmental extremes resulting from a changing climate can have profound implications for plant interactions in desert communities. Positive interactions can buffer plant communities from abiotic stress and consumer pressure caused by climatic extremes, but limited research has explored this empirically. We tested the hypothesis that the mechanism of shrub facilitation on an annual plant community can change with precipitation extremes in deserts. During years of extreme drought and above-average rainfall in a desert, we measured plant interactions and biomass while manipulating a soil moisture gradient and reducing consumer pressure...
September 25, 2017: New Phytologist
https://www.readbyqxmd.com/read/28944244/inherited-2q23-1-microdeletions-involving-the-mbd5-locus
#5
Shereen Tadros, Rubin Wang, Jonathan J Waters, Christine Waterman, Amanda L Collins, Morag N Collinson, Joo W Ahn, Dragana Josifova, Ravi Chetan, Ajith Kumar
BACKGROUND: Microdeletions of 2q23.1 disrupting MBD5 and loss of function mutations of MBD5 cause MBD5-Associated Neurodevelopmental disorders (MAND). Nearly all reported patients have been isolated cases of de novo origin. METHODS: This study investigates three families with inherited MBD5 mutations from three different Regional Genetics Centres in the UK. RESULTS: Two of the parents in the study had MBD5 deletions in a mosaic form. The parent with an MBD5 deletion in an apparently nonmosaic form has a psychiatric disorder in the absence of developmental delay or dysmorphism...
September 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28944019/utility-of-dna-barcoding-to-identify-rare-endemic-vascular-plant-species-in-trinidad
#6
Fazeeda N Hosein, Nigel Austin, Shobha Maharaj, Winston Johnson, Luke Rostant, Amanda C Ramdass, Sephra N Rampersad
The islands of the Caribbean are considered to be a "biodiversity hotspot." Collectively, a high level of endemism for several plant groups has been reported for this region. Biodiversity conservation should, in part, be informed by taxonomy, population status, and distribution of flora. One taxonomic impediment to species inventory and management is correct identification as conventional morphology-based assessment is subject to several caveats. DNA barcoding can be a useful tool to quickly and accurately identify species and has the potential to prompt the discovery of new species...
September 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28943478/sexual-dimorphism-of-metabolic-and-vascular-dysfunction-in-aged-mice-and-those-lacking-the-sphingosine-1-phosphate-receptor-3
#7
Amanda T Cao, Martina Mackova, Daniel Kerage, David N Brindley, Denise G Hemmings
Elderly people often suffer adverse health because of inflammation associated with poor metabolism and cardiovascular dysfunction, but these conditions present differently in men and women. We performed experiments in aged male and female mice to understand this sexual dimorphism. We focused on sphingosine 1-phosphate (S1P) signaling, which has both protective and detrimental effects on vascular and metabolic function. We examined vascular function of mesenteric (resistance) arteries from aged male and female wild-type (WT) mice compared to littermate S1P receptor 3 (S1PR3) knockouts (KO)...
September 21, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28943139/diagnostic-utility-of-core-needle-biopsy-versus-open-wedge-biopsy-for-pediatric-intraabdominal-solid-tumors-results-of-a-prospective-clinical-study
#8
Scott Deeney, Camille Stewart, Amanda L Treece, Jennifer O Black, Mark A Lovell, Timothy Garrington, Frederick Karrer, Jennifer Bruny
PURPOSE: The best method for diagnosing pediatric nonnephroblastoma solid intraabdominal tumors is unknown. We hypothesized that core needle biopsy (CNB) is noninferior to open wedge biopsy (OWB) for pathologic diagnosis. METHODS: We prospectively enrolled children aged 1day to 17years with radiographic evidence of nonnephroblastoma solid intraabdominal tumors scheduled for OWB from 5/2013 to 12/2015 at a single institution. Four 16-gauge CNBs were obtained, followed by OWB...
September 4, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28943021/leadership-for-addressing-aging-in-america-the-health-and-aging-policy-fellowship
#9
Pamela Z Cacchione, Gary Epstein-Lubow, Amanda Borer, Peter Curran, Annette DeVito Dabbs, Julia Dreissen, Brian Kaskie, Fazal Khan, Madeline Naegle, Anne Ordway, Lynn F Reinke, Gary Stein, Turner West, Katie Wright, Sharon K Inouye
The Health and Aging Policy Fellows Program funded by The John A. Hartford Foundation and Atlantic Philanthropies trains future leaders to influence healthcare policy, systems, and program development in aging. Following a rigorous residential training in Washington, DC, Fellows establish placements of up to 1 year in the executive, legislative, or judicial branch of government, at a federal agency, state or community agency or committee, or with a nongovernmental organization. The 2016-2017 Fellows' activities represent a broad scope of work, including contributions to national and local policy priorities expected to build over time far beyond the core fellowship year...
October 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28942920/adipose-tissue-macrophage-derived-exosomal-mirnas-can-modulate-in%C3%A2-vivo-and-in%C3%A2-vitro-insulin-sensitivity
#10
Wei Ying, Matthew Riopel, Gautam Bandyopadhyay, Yi Dong, Amanda Birmingham, Jong Bae Seo, Jachelle M Ofrecio, Joshua Wollam, Angelina Hernandez-Carretero, Wenxian Fu, Pingping Li, Jerrold M Olefsky
MiRNAs are regulatory molecules that can be packaged into exosomes and secreted from cells. Here, we show that adipose tissue macrophages (ATMs) in obese mice secrete miRNA-containing exosomes (Exos), which cause glucose intolerance and insulin resistance when administered to lean mice. Conversely, ATM Exos obtained from lean mice improve glucose tolerance and insulin sensitivity when administered to obese recipients. miR-155 is one of the miRNAs overexpressed in obese ATM Exos, and earlier studies have shown that PPARγ is a miR-155 target...
September 19, 2017: Cell
https://www.readbyqxmd.com/read/28942722/pharmacy-workload-benchmarking-establishing-a-health-system-outpatient-infusion-productivity-metric
#11
Jeffrey S Reichard, David M Garbarz, Amanda L Teachey, Jonathan Allgood, M Jay Brown
Background and objectives Current productivity assessment models lack the ability to measure the quality of pharmacy services through workload validation. The goal of our efforts was to create a model to more accurately assess workload at multiple outpatient infusion centers. Method Current procedural terminology codes were identified as representative of the key drivers of pharmacy workload. Fourteen current procedural terminology codes representing medication orders were selected and categorized into eight distinctive groups associated with varying amounts of pharmacy workload...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/28942675/cycling-through-cancer-exploring-childhood-cancer-survivors-experiences-of-well-and-ill-being
#12
Shaunna M Burke, Jennifer Brunet, Amanda Wurz, Christina Butler, Andrea Utley
The benefits of informal physical activity during recovery from childhood cancer have rarely been investigated. This study adopted a multiple case study approach to explore the impact of recreational cycling on childhood cancer survivors' experiences of well- and ill-being. Three semistructured interviews were conducted over a 3-month period with four survivors to explore their experiences of physical, psychological, and social well- and ill-being. Within-case analysis followed by cross-case analysis identified three themes that captured their well- and ill-being experiences with recreational cycling and cancer: (a) cultivating feelings and emotions, (b) experiencing physical changes, and (c) encountering positive and negative social interactions...
September 23, 2017: Adapted Physical Activity Quarterly: APAQ
https://www.readbyqxmd.com/read/28942268/computational-fluid-dynamics-and-additive-manufacturing-to-diagnose-and-treat-cardiovascular-disease
#13
REVIEW
Amanda Randles, David H Frakes, Jane A Leopold
Noninvasive engineering models are now being used for diagnosing and planning the treatment of cardiovascular disease. Techniques in computational modeling and additive manufacturing have matured concurrently, and results from simulations can inform and enable the design and optimization of therapeutic devices and treatment strategies. The emerging synergy between large-scale simulations and 3D printing is having a two-fold benefit: first, 3D printing can be used to validate the complex simulations, and second, the flow models can be used to improve treatment planning for cardiovascular disease...
September 20, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28941491/vitiligo-surgery-shuffling-melanocytes
#14
REVIEW
Amanda F Nahhas, Tasneem F Mohammad, Iltefat H Hamzavi
Vitiligo is a disorder characterized by the development of depigmented macules and patches secondary to melanocyte destruction. Several treatment options are available, including medical, light-based, and surgical therapies, that are often used in combination to achieve maximal repigmentation. Vitiligo surgery is an effective yet underperformed treatment, mainly because of lack of awareness and availability. The purpose of this article is to review one method of vitiligo surgery, the melanocyte-keratinocyte transplantation procedure, and discuss its utility in treating vitiligo...
October 2017: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/28941221/how-well-do-rheumatology-fellows-manage-acute-infusion-reactions-a-pilot-curricular-intervention
#15
Jason J Weiner, Amanda M Eudy, Lisa G Criscione-Schreiber
BACKGROUND: Infusible DMARDs are commonly prescribed in rheumatology and other fields. There are no published formal educational curricula rheumatology fellowship programs can use to teach infusion reaction management skills to fellows. We aimed to better understand this educational gap, and implement and assess the effectiveness of an experiential curriculum on acute infusion reaction management. METHODS: We included current rheumatology fellows and recent graduates from five fellowship programs...
September 21, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28941034/genome-wide-interactions-with-dairy-intake-for-body-mass-index-in-adults-of-european-descent
#16
Caren E Smith, Jack L Follis, Hassan S Dashti, Toshiko Tanaka, Mariaelisa Graff, Amanda M Fretts, Tuomas O Kilpeläinen, Mary K Wojczynski, Kris Richardson, Mike A Nalls, Christina-Alexandra Schulz, Yongmei Liu, Alexis C Frazier-Wood, Esther van Eekelen, Carol Wang, Paul S de Vries, Vera Mikkilä, Rebecca Rohde, Bruce M Psaty, Torben Hansen, Mary F Feitosa, Chao-Qiang Lai, Denise K Houston, Luigi Ferruci, Ulrika Ericson, Zhe Wang, Renée de Mutsert, Wendy H Oddy, Ester A L de Jonge, Ilkka Seppälä, Anne E Justice, Rozenn N Lemaitre, Thorkild I A Sørensen, Michael A Province, Laurence D Parnell, Melissa E Garcia, Stefania Bandinelli, Marju Orho-Melander, Stephen S Rich, Frits R Rosendaal, Craig E Pennell, Jessica C Kiefte-de Jong, Mika Kähönen, Kristin L Young, Oluf Pedersen, Stella Aslibekyan, Jerome I Rotter, Dennis O Mook-Kanamori, M Carola Zillikens, Olli T Raitakari, Kari E North, Kim Overvad, Donna K Arnett, Albert Hofman, Terho Lehtimäki, Anne Tjønneland, André G Uitterlinden, Fernando Rivadeneira, Oscar H Franco, J Bruce German, David S Siscovick, L Adrienne Cupples, José M Ordovás
SCOPE: Body weight responds variably to the intake of dairy foods. Genetic variation may contribute to inter-individual variability in associations between body weight and dairy consumption. METHODS AND RESULTS: We conducted a genome-wide interaction study to discover genetic variants that account for variation in BMI in the context of low-fat, high-fat and total dairy intake in cross-sectional analysis. Data from 9 discovery studies (up to 25,513 European descent individuals) were meta-analyzed...
September 21, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28940864/the-22q11-2-deletion-syndrome-cancer-predisposition-platelet-abnormalities-and-cytopenias
#17
REVIEW
Michele P Lambert, Abinaya Arulselvan, Amanda Schott, Stephen J Markham, Terrance B Crowley, Elaine H Zackai, Donna M McDonald-McGinn
The 22q11.2 deletion syndrome (DS) is associated with variable phenotypic expression as findings range from severely affected individuals with the classical triad of DiGeorge and velocardiofacial syndromes, including congenital heart disease, immunodeficiency, hypocalcemia, and palatal abnormalities, to subtly affected adults who only come to attention following the diagnosis of a more severely affected child. The multiple manifestations can affect all organ systems, including the hematologic system resulting in baseline lower platelet counts for individuals with 22q11...
September 22, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28940645/lineage-tracing-reveals-dynamic-changes-in-oligodendrocyte-precursor-cells-following-cuprizone-induced-demyelination
#18
Emily G Baxi, Joseph DeBruin, Jing Jin, Hayley J Strasburger, Matthew D Smith, Jennifer L Orthmann-Murphy, Jason T Schott, Amanda N Fairchild, Dwight E Bergles, Peter A Calabresi
The regeneration of oligodendrocytes is a crucial step in recovery from demyelination, as surviving oligodendrocytes exhibit limited structural plasticity and rarely form additional myelin sheaths. New oligodendrocytes arise through the differentiation of platelet-derived growth factor receptor α (PDGFRα) expressing oligodendrocyte progenitor cells (OPCs) that are widely distributed throughout the CNS. Although there has been detailed investigation of the behavior of these progenitors in white matter, recent studies suggest that disease burden in multiple sclerosis (MS) is more strongly correlated with gray matter atrophy...
September 22, 2017: Glia
https://www.readbyqxmd.com/read/28940541/ebstein-anomaly-and-sudden-childhood-death
#19
Amanda Freeman, Roger W Byard
A 13-year-old girl is reported who died suddenly and unexpectedly in her sleep from previously undiagnosed Ebstein anomaly. At autopsy, there was dilatation of the right atrium with marked dilatation of the right auricle and apical displacement of the tricuspid valve into the right ventricular cavity with atrialization of the upper portion of the right ventricle. There were also prominent dysplastic changes in both the septal and posterior leaflets of the tricuspid valve with thickening of the valve and fusion of leaflets to the wall of the ventricle...
September 20, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28940320/a-randomized-clinical-trial-examining-the-effect-of-video-based-prevention-of-alcohol-and-marijuana-use-among-recent-sexual-assault-victims
#20
Kate Walsh, Amanda K Gilmore, Patricia Frazier, Linda Ledray, Ron Acierno, Kenneth J Ruggiero, Dean G Kilpatrick, Heidi S Resnick
BACKGROUND: This study examined whether a brief video intervention (Prevention of Postrape Stress; PPRS) delivered in the emergency department to recent sexual assault (SA) victims reduced alcohol and marijuana use at three points over the course of a six-month follow-up compared to treatment as usual (TAU) and an active control condition (Pleasant Imagery and Relaxation Information; PIRI). Prior assault history, minority status, and pre-SA substance use also were examined as moderators of intervention efficacy...
September 20, 2017: Alcoholism, Clinical and Experimental Research
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