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JOURNAL ARTICLE
Sushant Sharma Chaudhary, Andrew Toivonen, Gaurav Waratkar, Geoffrey Mo, Deep Chatterjee, Sarah Antier, Patrick Brockill, Michael W Coughlin, Reed Essick, Shaon Ghosh, Soichiro Morisaki, Pratyusava Baral, Amanda Baylor, Naresh Adhikari, Patrick Brady, Gareth Cabourn Davies, Tito Dal Canton, Marco Cavaglia, Jolien Creighton, Sunil Choudhary, Yu-Kuang Chu, Patrick Clearwater, Luke Davis, Thomas Dent, Marco Drago, Becca Ewing, Patrick Godwin, Weichangfeng Guo, Chad Hanna, Rachael Huxford, Ian Harry, Erik Katsavounidis, Manoj Kovalam, Alvin K Y Li, Ryan Magee, Ethan Marx, Duncan Meacher, Cody Messick, Xan Morice-Atkinson, Alexander Pace, Roberto De Pietri, Brandon Piotrzkowski, Soumen Roy, Surabhi Sachdev, Leo P Singer, Divya Singh, Marek Szczepanczyk, Daniel Tang, Max Trevor, Leo Tsukada, Verónica Villa-Ortega, Linqing Wen, Daniel Wysocki
Multimessenger searches for binary neutron star (BNS) and neutron star-black hole (NSBH) mergers are currently one of the most exciting areas of astronomy. The search for joint electromagnetic and neutrino counterparts to gravitational wave (GW)s has resumed with ALIGO's, AdVirgo's and KAGRA's fourth observing run (O4). To support this effort, public semiautomated data products are sent in near real-time and include localization and source properties to guide complementary observations. In preparation for O4, we have conducted a study using a simulated population of compact binaries and a mock data challenge (MDC) in the form of a real-time replay to optimize and profile the software infrastructure and scientific deliverables...
April 30, 2024: Proceedings of the National Academy of Sciences of the United States of America
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JOURNAL ARTICLE
Emily Wiecek, Anna Kosovicheva, Zain Ahmed, Amanda Nabasaliza, Melanie Kazlas, Kimberley Chan, David G Hunter, Peter J Bex
PURPOSE: Individuals with amblyopia experience central vision deficits, including loss of visual acuity, binocular vision, and stereopsis. In this study, we examine the differences in peripheral binocular imbalance in children with anisometropic amblyopia, strabismic amblyopia, and typical binocular vision to determine if there are systematic patterns of deficits across the visual field. METHODS: This prospective cohort study recruited 12 participants with anisometropic amblyopia, 10 with strabismic amblyopia, and 10 typically sighted controls (age range, 5-18 years)...
April 1, 2024: Investigative Ophthalmology & Visual Science
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JOURNAL ARTICLE
Andreu Fernández-Codina, Tatiana Nevskaya, Murray Baron, C Thomas Appleton, Matthew J Cecchini, Amanda Philip, Maha El-Shimy, Louise Vanderhoek, Iago Pinal-Fernández, Janet E Pope
OBJECTIVE: We explored the efficacy and safety of brentuximab vedotin, a chimeric anti-CD30 antibody drug conjugate, in patients with severe active diffuse cutaneous systemic sclerosis (dcSSc). METHODS: This phase II proof-of-concept, single center, open-label, single arm, investigator-initiated trial included patients ≥18 years, with dcSSc, modified Rodnan skin score (mRSS) ≥15 with <5 years since the first non-Raynaud's symptom and/or skin worsening despite immunosuppression who were treated with intravenous brentuximab vedotin 0...
April 23, 2024: Rheumatology
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JOURNAL ARTICLE
Jiyun Zhang, Jens A Hauch, Christoph J Brabec
ConspectusIn the ever-increasing renewable-energy demand scenario, developing new photovoltaic technologies is important, even in the presence of established terawatt-scale silicon technology. Emerging photovoltaic technologies play a crucial role in diversifying material flows while expanding the photovoltaic product portfolio, thus enhancing security and competitiveness within the solar industry. They also serve as a valuable backup for silicon photovoltaic, providing resilience to the overall energy infrastructure...
April 23, 2024: Accounts of Chemical Research
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JOURNAL ARTICLE
Amanda Rodrigues Rehem, Letícia Rampazzo da Gama Viveiro, Evelyn Luzia De Souza Santos, Paulo Henrique Fonseca do Carmo, Newton Soares da Silva, Juliana Campos Junqueira, Liliana Scorzoni
Cryptococcosis is an invasive mycosis caused mainly by Cryptococcus gattii and C. neoformans and is treated with amphotericin B (AMB), fluconazole and 5-fluorocytosine. However, antifungal resistance, limited and toxic antifungal arsenal stimulate the search for therapeutic strategies such as drug repurposing. Among the repurposed drugs studied, the selective serotonin reuptake inhibitors (SSRIs) have shown activity against Cryptococcus spp. However, little is known about the antifungal effect of duloxetine hydrochloride (DH), a selective serotonin and norepinephrine reuptake inhibitor (SSNRI), against C...
April 23, 2024: Folia Microbiologica
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JOURNAL ARTICLE
Ingrid S Tien, Junok Kim, Amanda R Johnson, Jeffrey J Wood
PURPOSE: Recent research has suggested that autism may present differently in girls compared to boys, encouraging the exploration of a sex-differential diagnostic criteria. Gender differences in diagnostic assessments have been shown on the ADOS-II, such that, on average, females score significantly lower than males on all scales and are less likely to show atypicality on most items related to social communicative difficulties. Yet, gender differences in the latent structure of instruments like the ADOS-II have not been examined systematically...
April 23, 2024: Journal of Autism and Developmental Disorders
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JOURNAL ARTICLE
Mark Milhaven, Heba A Bakry, Anuvi Batra, Amanda M Bermingham, Gloria Grama, Jacob Kebe, Shawn S Martinez, Rishika V Mudunuri, Megan R Nelson, Evie T Nguyen, Mia M Peterson, Alexis Pruitt, Kristan Tran, Akarshi Brar, Gabriella Cerna, Elaine Chaffee, Steven M Caruso, Susanne P Pfeifer
Amabiko is a lytic subcluster BE2 bacteriophage that infects Streptomyces scabiei -a bacterium causing common scab in potatoes. Its 131,414 bp genome has a GC content of 49.5% and contains 245 putative protein-coding genes, 45 tRNAs, and one tmRNA. Amabiko is closely related to Streptomyces bacteriophage MindFlayer (gene content similarity: 86.5%).
April 23, 2024: Microbiology Resource Announcements
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JOURNAL ARTICLE
Anne T Berg, Christopher H Thompson, Leah Schust Myers, Erica Anderson, Lindsey Evans, Ariela J E Kaiser, Katherine Paltell, Amanda N Nili, Jean-Marc DeKeyser, Tatiana V Abramova, Gerry Nesbitt, Shawn Egan, Carlos G Vanoye, Alfred L George
SCN2A-related disorders secondary to altered function in the voltage-gated sodium channel NaV1.2 are rare with clinically heterogeneous expressions that include epilepsy, autism, and multiple severe to profound impairments and other conditions. To advance understanding of the clinical phenotypes and their relation to channel function, 81 patients (36, 44% female, median age 5.4 years) with 69 unique SCN2A variants were systematically phenotyped and their NaV1.2 channel function systematically assessed. Participants were recruited through the FamileSCN2A Foundation...
April 23, 2024: Brain
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JOURNAL ARTICLE
Amanda Rosenthal, Margit L W Juhasz, Crystal Chang, Nima M Gharavi
BACKGROUND: Lasers may present an alternative treatment modality for the management of nonmelanoma skin cancer (NMSC). OBJECTIVE: To investigate lasers as a definitive treatment of NMSC. METHODS: A comprehensive search was performed on MEDLINE, the Cochrane Library, and the National Institutes of Health (www.clinicaltrials.gov). The Preferred Reporting Items for Systematic Reviews and Meta-Analysis was used to finalize a list of relevant literature studies evaluating the role of laser therapy for NMSC...
April 23, 2024: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
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REVIEW
Laventa M Obare, Rachel H Bonami, Amanda C Doran, Celestine N Wanjalla
Atherosclerosis remains a leading cause of cardiovascular disease (CVD) globally, with the complex interplay of inflammation and lipid metabolism at its core. Recent evidence suggests a role of B cells in the pathogenesis of atherosclerosis; however, this relationship remains poorly understood, particularly in the context of HIV. We review the multifaceted functions of B cells in atherosclerosis, with a specific focus on HIV. Unique to atherosclerosis is the pivotal role of natural antibodies, particularly those targeting oxidized epitopes abundant in modified lipoproteins and cellular debris...
April 23, 2024: Journal of Cellular Physiology
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JOURNAL ARTICLE
Katerina Z Kolokotroni, Therese E Fozard, Danielle L Selby, Amanda A Harrison
Research has largely focused on how attentional bias to smoking-related cues and impulsivity independently influence the development and maintenance of cigarette smoking, with limited exploration of the relationship between these mechanisms. The current experiments systematically assessed relationships between multiple dimensions of impulsivity and attentional bias, at different stages of attention, in smokers varying in nicotine dependency and deprivation. Nonsmokers (NS; n = 26), light-satiated smokers (LS; n = 25), heavy-satiated smokers (HS; n = 23) and heavy 12-hour nicotine-deprived smokers (HD; n = 30) completed the Barratt Impulsivity Scale, delayed discounting task, stop-signal task, information sampling task and a visual dot-probe assessing initial orientation (200 ms) and sustained attention (2000 ms) toward smoking-related cues...
April 22, 2024: Behavioural Pharmacology
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JOURNAL ARTICLE
Schuyler Kremer, Valentina Shakhnovich, Amanda K Riffel, Lisa Harvey, Chad R Borges
Blood plasma storage is a crucial element of pediatric biobanking. Improperly stored or handled specimens (e.g., at > -30°C) can result in altered biomolecular compositions that no longer reflects in vivo reality. We report application of a previously developed assay in adults-the ΔS-Cys-Albumin assay, which facilitates estimation of plasma and serum exposure to thawed conditions-to a population of pediatric EDTA plasma samples from patients aged 3-18 years to determine the assay's applicability, estimate its reference range for pediatric samples, and assess the impact of pre-centrifugation delay at 0°C...
April 23, 2024: Biopreservation and Biobanking
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JOURNAL ARTICLE
Angélica Ferraz Gomes, Girlane Oliveira Rocha, Caroline Scabini, Jayne Ferreira da Silva Oliveira, Déborah Neres Oliveira, Luise Carvalho Mota, Brenda Novais Almeida Neves, Amanda Menezes Dos Santos, Urias Santos Araújo, Bruno Oliveira Moreira, Flávio Mendes de Souza, Maiara Prates de Almeida, Juliano Geraldo Amaral, Jorge Maurício David
The present study describes the seasonal and circadian variations of the major compounds from Lippia alba leaves. SPSS was used to identify, quantify, and associate the variations in the secondary metabolites of this species through HPLC/DAD analysis of the leaves hydroethanolic extracts of six selected L. alba specimens. For the circadian study, the samples were collected at four different daily hours in each year's season. For the seasonal study, the samples were collected monthly from the same individuals for two consecutive years (2018 and 2019)...
April 23, 2024: Chemistry & Biodiversity
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JOURNAL ARTICLE
Sabra L Katz-Wise, Snehal N Shah, Patrice Melvin, Elizabeth R Boskey, Amanda W Grice, Susan Kornetsky, Tina Young Poussaint, Melicia Y Whitley, Anne M Stack, S Jean Emans, Benjamin Hoerner, James J Horgan, Valerie L Ward
Equity, diversity, and inclusion (EDI) research is increasing, and there is a need for a more standardized approach for methodological and ethical review of this research. A supplemental review process for EDI-related human subject research protocols was developed and implemented at a pediatric academic medical center (AMC). The goal was to ensure that current EDI research principles are consistently used and that the research aligns with the AMC's declaration on EDI. The EDI Research Review Committee, established in January 2022, reviewed EDI protocols and provided recommendations and requirements for addressing EDI-related components of research studies...
April 23, 2024: Pediatrics
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JOURNAL ARTICLE
Luigi Lorini, Paolo Bossi, Amanda Psyrri, Pierluigi Bonomo
INTRODUCTION: Human papillomavirus Virus (HPV)-associated oropharyngeal squamous cell carcinoma (OSCC) has increased in incidence in recent decades and represents a heterogeneous disease entity in the context of Head and Neck Squamous Cell Carcinoma (HNSCC), in terms of disease prognosis. Treatment of locoregionally advanced OSCC is mainly based on concurrent chemoradiotherapy. Given the younger age of patients, if compared with HPV-negative counterparts, and the high cure rates, the acute- and long-term toxicity in survivors represents a field of interest...
2024: Frontiers in Oncology
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JOURNAL ARTICLE
Sanjay K Singh, Amanda Prislovsky, Donald N Ngwa, Undral Munkhsaikhan, Ammaar H Abidi, David D Brand, Alok Agrawal
The biosynthesis of C-reactive protein (CRP) in the liver is increased in inflammatory diseases including rheumatoid arthritis. Previously published data suggest a protective function of CRP in arthritis; however, the mechanism of action of CRP remains undefined. The aim of this study was to evaluate the effects of human CRP on the development of collagen-induced arthritis (CIA) in mice which is an animal model of autoimmune inflammatory arthritis. Two CRP species were employed: wild-type CRP which binds to aggregated IgG at acidic pH and a CRP mutant which binds to aggregated IgG at physiological pH...
2024: Frontiers in Immunology
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JOURNAL ARTICLE
Amanda L Trout, Christopher J McLouth, Jenne M Westberry, Tomoko Sengoku, Melinda E Wilson
Estrogens, such as the biologically active 17-β estradiol (E2), regulate not only reproductive behaviors in adults, but also influence neurodevelopment and neuroprotection in both females and males. E2, contingent upon the timing and concentration of the therapy, is neuroprotective in female and male rodent models of stroke. In Vivo studies suggest that E2 may partially mediate this neuroprotection, particularly in the cortex, via ERα. In Vitro studies, utilizing a chemically induced ischemic injury in cortical explants from both sexes, suggest that ERα or ERβ signaling is needed to mediate the E2 protection...
2024: Aging brain
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JOURNAL ARTICLE
Frank Amankwah Adu, Collins Atta Poku, Amanda Parko Adu, Lydia Boampong Owusu
BACKGROUND AND AIMS: Diabetes mellitus (DM) can result in detrimental complications which are connected with long-term impairments and disabilities. Chronic complications are well-known consequences of type 2 diabetes mellitus (T2DM) progression, which reduce patient quality of life, place a burden on the healthcare system, and increase mortality. Measures to promote health outcomes for people with DM are scanty; the study therefore aimed at determining the effects of self-management and social support on glycemic control of T2DM with complications in Ghana...
April 2024: Health Science Reports
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JOURNAL ARTICLE
Calebe P Mendes, Wido R Albert, Zachary Amir, Marc Ancrenaz, Eric Ash, Badrul Azhar, Henry Bernard, Jedediah Brodie, Tom Bruce, Elliot Carr, Gopalasamy Reuben Clements, Glyn Davies, Nicolas J Deere, Yoan Dinata, Christl A Donnelly, Somphot Duangchantrasiri, Gabriella Fredriksson, Benoit Goossens, Alys Granados, Andrew Hearn, Jason Hon, Tom Hughes, Patrick Jansen, Kae Kawanishi, Margaret Kinnaird, Sharon Koh, Alice Latinne, Matthew Linkie, Federica Loi, Anthony J Lynam, Erik Meijaard, Jayasilan Mohd-Azlan, Jonathan H Moore, Senthilvel K S S Nathan, Dusit Ngoprasert, Wilson Novarino, Ilyas Nursamsi, Timothy O'Brien, Robert Ong, John Payne, Dolly Priatna, D Mark Rayan, Glen Reynolds, Rustam Rustam, Sasidhran Selvadurai, Amanda Shia, Muhammad Silmi, Pablo Sinovas, Kriangsak Sribuarod, Robert Steinmetz, Matthew J Struebig, Ronglarp Sukmasuang, Sunarto Sunarto, Tarmizi Tarmizi, Arjun Thapa, Carl Traeholt, Oliver R Wearn, Hariyo B Wibisono, Andreas Wilting, Seth Timothy Wong, Siew Te Wong, Jettie Word, Wen Xuan Chiok, Zainal Zahari Zainuddin, Matthew Scott Luskin
Information on tropical Asian vertebrates has traditionally been sparse, particularly when it comes to cryptic species inhabiting the dense forests of the region. Vertebrate populations are declining globally due to land-use change and hunting, the latter frequently referred as "defaunation." This is especially true in tropical Asia where there is extensive land-use change and high human densities. Robust monitoring requires that large volumes of vertebrate population data be made available for use by the scientific and applied communities...
April 22, 2024: Ecology
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JOURNAL ARTICLE
Meghan A Costello, Corey Pettit, Amanda F Hellwig, Gabrielle L Hunt, Natasha A Bailey, Joseph P Allen
This study examines links between self-disclosure and relationship quality with close friends from adolescence to adulthood. A diverse community sample of adolescents (N = 184) participated in survey and observational measures annually from ages 13 through 29, along with their close friends and romantic partners. Random intercept cross-lagged panel modeling (RICLPM) was used to parse markers of within-individual change from age 13 to 18. Long-term longitudinal path models also investigated cascading associations among self-disclosure and relationship quality, on aggregate, from adolescence to adulthood...
April 22, 2024: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
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