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https://www.readbyqxmd.com/read/28721461/influence-of-adjuvant-detached-mindfulness-and-stress-management-training-compared-to-pharmacologic-treatment-in-primiparae-with-postpartum-depression
#1
Mohammad Ahmadpanah, Marzieh Nazaribadie, Elham Aghaei, Ali Ghaleiha, Azade Bakhtiari, Mohammad Haghighi, Dena Sadeghi Bahmani, Amineh Akhondi, Hafez Bajoghli, Leila Jahangard, Edith Holsboer-Trachsler, Serge Brand
Ten to 15% of mothers experience postpartum depression (PPD). If untreated, PPD may negatively affect mothers' and infants' mental health in the long term. Accordingly, effective treatments are required. In the present study, we investigated the effect of detached mindfulness (DM) and stress management training (SMT) as adjuvants, compared to pharmacologic treatment only, on symptoms of depression in women with PPD. Forty-five primiparae (mean age: M = 24.5 years) with diagnosed PPD and treated with an SSRI (citalopram; CIT) took part in the study...
July 18, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/28718958/multiplex-pcr-scheme-for-variant-plasmid-mediated-class-c-%C3%AE-lactamase-typing
#2
Le Van Chuong, Virapong Prachayasittikul, Chartchalerm Isarankura Na Ayudhya, Ratana Lawung
BACKGROUND: An increasing of prevalence and diversification of plasmid-mediated AmpC (pAmpC) has been emerged worldwide. The incidence of pAmpC resulted in increasing β-lactamase production and conferred resistance to almost all β-lactam antibiotics excluding carbapenems. The lack of standard method for pAmpC identification and classification exert a challenge in epidemiological surveillance and infection control practices. METHODS: A robust, single tube multiplex PCR has been developed to classify six different pAmpC groups including CIT (CMY-2 like, LAT and CFE), ECB (ACT, MIR), MOX & CMY-1 like, DHA, ACC, and FOX...
July 18, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28712148/influence-of-kidney-offer-acceptance-behavior-on-metrics-of-allocation-efficiency
#3
Andrew Wey, Nicholas Salkowski, Bertram L Kasiske, Ajay K Israni, Jon J Snyder
We investigated associations of deceased donor kidney offer acceptance with likelihood of the kidney being discarded, cold ischemia time at transplant (CIT), and likelihood of the kidney being exported outside the donation service area (DSA). We used kidney offers from donors in the Scientific Registry of Transplant Recipients July 1, 2015-June 30, 2016, and a stratified logistic regression to estimate odds ratios of acceptance for candidates waitlisted in a DSA. We estimated associations between these ratios and likelihood of discard or export and CIT at transplant...
July 16, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28711907/up-regulation-of-cit-promotes-the-growth-of-colon-cancer-cells
#4
Zehua Wu, Xiangying Zhu, Wendi Xu, Yu Zhang, Lin Chen, Fabo Qiu, Binyuan Zhang, Liqun Wu, Zhihai Peng, Huamei Tang
Colon cancer is one of the major causes of cancer mortality worldwide. However, the underlying mechanism and therapeutic targets of colon cancer have not yet been fully elucidated. In the present study, we demonstrate that citron rho-interacting, serine/threonine kinase 21 (CIT) promotes the growth of human colon cancer cells. CIT is overexpressed in human colon cancer tissues and cell lines. High expression of CIT predicts poor survival for patients with colon cancer. In colon cancer cells, CIT knockdown represses cellular proliferation and colony formation...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28707455/human-brown-adipose-tissue-as-a-target-for-obesity-management-beyond-cold-induced-thermogenesis
#5
REVIEW
R K C Loh, B A Kingwell, A L Carey
Elevating energy expenditure via adaptive thermogenesis in brown adipose tissue (BAT) is a potential strategy to reverse obesity. Much early enthusiasm for this approach, based on rodent studies, was tempered by the belief that BAT was relatively inconsequential in healthy adult humans. Interest was reinvigorated a decade ago when a series of studies re-identified BAT, primarily in upper thoracic regions, in adults. Despite the ensuing explosion of pre-clinical investigations and identification of an extensive list of potential target molecules for BAT recruitment, our understanding of human BAT physiology remains limited, particularly regarding interventions which might hold therapeutic promise...
July 14, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28706987/influence-of-cold-ischemia-time-in-kidney-transplants-from-small-pediatric-donors
#6
Liise K Kayler, Michelle Lubetzky, Xia Yu, Patricia Friedmann
BACKGROUND: Clinicians may be reluctant to transplant small pediatric kidneys that have prolonged cold ischemia time (CIT) for fear of an additional deleterious effect because pediatric grafts are thought to be more sensitive to ischemia. We aimed to assess the risks associated with transplantation of small pediatric kidneys with prolonged CIT. METHODS: We performed a retrospective cohort study examining US registry data between 1998 and 2013 of adult first-time kidney-only recipients of small pediatric kidneys from donors weighing 10 to 20 kg, stratified by CIT levels of 0 to 18 (n = 1413), 19 to 30 (n = 1116), and longer than 30 (n = 338) hours...
July 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28706980/impact-of-cold-ischemia-time-in-kidney-transplants-from-donation-after-circulatory-death-donors
#7
Liise Kayler, Xia Yu, Carlos Cortes, Michelle Lubetzky, Patricia Friedmann
BACKGROUND: Deceased-donor kidneys are exposed to ischemic events from donor instability during the process of donation after circulatory death (DCD). Clinicians may be reluctant to transplant DCD kidneys with prolonged cold ischemia time (CIT) for fear of an additional deleterious effect. METHODS: We performed a retrospective cohort study examining US registry data between 1998 and 2013 of adult first-time kidney-only recipients of paired kidneys (derived from the same donor transplanted into different recipients) from DCD donors...
July 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28706976/donor-diabetes-and-prolonged-cold-ischemia-time-synergistically-increase-the-risk-of-graft-failure-after-liver-transplantation
#8
Isabel M A Brüggenwirth, Natasha H Dolgin, Robert J Porte, Adel Bozorgzadeh, Paulo N A Martins
BACKGROUND: Both prolonged cold ischemia time (CIT) and donor history of diabetes mellitus (DM) are associated with reduced graft survival after liver transplantation. However, it is unknown whether the adverse effect of prolonged CIT on posttransplant graft survival is more pronounced after transplant with DM versus non-DM donor grafts. METHODS: The study sample included 58 226 liver transplant recipients (2002-2015) from the Scientific Registry of Transplant Recipients...
July 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28701519/nineteen-complex-related-factor-prp45-is-required-for-the-early-stages-of-cotranscriptional-spliceosome-assembly
#9
Martina Hálová, Ondřej Gahura, Martin Převorovský, Zdeněk Cit, Marian Novotný, Anna Valentová, Kateřina Abrhámová, František Půta, Petr Folk
Splicing in S. cerevisiae has been shown to proceed cotranscriptionally, but the nature of the coupling remains a subject of debate. Here, we examine the effect of nineteen complex-related splicing factor Prp45 (a homolog of SNW1/SKIP) on cotranscriptional splicing. RNA-sequencing and RT-qPCR showed elevated pre-mRNA levels but only limited reduction of spliced mRNAs in cells expressing C-terminally truncated Prp45, Prp45(1-169). Assays with a series of reporters containing the AMA1 intron with regulatable splicing confirmed decreased splicing efficiency and showed the leakage of unspliced RNAs in prp45(1-169) cells...
July 12, 2017: RNA
https://www.readbyqxmd.com/read/28697541/first-experience-of-cadaveric-renal-transplantation-in-sri-lanka
#10
P K Harrischandra, D N Jayatunge, U B Rambukwella, I B Sumithraarachchi, U I Karunadasa, A S Abeyagunawardena
Objectives: To analyse the outcome of 50 consecutive cadaveric renal transplants performed in Sri Lanka. Methods: This was a single-centre longitudinal cohort study conducted in the Nephrology and Kidney Transplant Unit, Teaching Hospital Kandy, Sri Lanka. Records of 50 Sri Lankan cadaveric renal transplant recipients from 7th December 2004 to 1st September 2013 were reviewed and categorized according to early graft function, cold ischaemia time and the duration of dialysis before surgery...
June 30, 2017: Ceylon Medical Journal
https://www.readbyqxmd.com/read/28696530/immunogenicity-and-safety-of-single-dose-13-valent-pneumococcal-conjugate-vaccine-in-pediatric-and-adolescent-oncology-patients
#11
Te-Yu Hung, Rishi S Kotecha, Christopher C Blyth, Sarah K Steed, Ruth B Thornton, Anne L Ryan, Catherine H Cole, Peter C Richmond
BACKGROUND: Children receiving immunosuppressive treatment for cancer are at high risk for invasive pneumococcal disease. The 13-valent pneumococcal conjugate vaccine (PCV13) can prevent pneumococcal disease in healthy children; however, there is an absence of literature regarding the benefit of PCV13 in immunocompromised children with cancer. METHODS: A prospective, open-label cohort study recruited children between ages 1 and 18 years who were receiving active immunosuppressive therapy (AIT) or were within 12 months after completing immunosuppressive therapy (CIT)...
July 11, 2017: Cancer
https://www.readbyqxmd.com/read/28674376/characterization-of-h-box-region-mutants-of-walk-inert-to-the-action-of-waldiomycin-in-bacillus-subtilis
#12
Akinori Kato, Shuhei Ueda, Taku Oshima, Yoichi Inukai, Toshihide Okajima, Masayuki Igarashi, Yoko Eguchi, Ryutaro Utsumi
The WalK/WalR two-component system is essential for cell wall metabolism and thus for cell growth in Bacillus subtilis. Waldiomycin was previously isolated as an antibiotic that targeted WalK, the cognate histidine kinase (HK) of the response regulator, WalR, in B. subtilis. To gain further insights into the action of waldiomycin on WalK and narrow down its site of action, mutations were introduced in the H-box region, a well-conserved motif of the bacterial HKs of WalK. The half-maximal inhibitory concentrations (IC50s) of waldiomycin against purified WalK protein with triple substitutions in the H-box region, R377M/R378M/S385A and R377M/R378M/R389M, were 26...
July 1, 2017: Journal of General and Applied Microbiology
https://www.readbyqxmd.com/read/28674240/molecular-genetic-analysis-of-consanguineous-families-with-primary-microcephaly-identified-pathogenic-variants-in-the-aspm-gene
#13
Muzammil Ahmad Khan, Christian Windpassinger, Muhammad Zeeshan Ali, Muhammad Zubair, Hadia Gul, Safdar Abbas, Saadullah Khan, Muhammad Badar, Ramzi M Mohammad, Zafar Nawaz
Autosomal recessive primary microcephaly is a rare genetic disorder that is characterized by reduced head circumference and a varying degree of intellectual disability. Genetic studies on consanguineous families with primary microcephaly have identified 15 (MCPH) causative genes that include MCPH1, WDR62, CDK5RAP2, CASC5, ASPM, CENPJ, STIL, CEP135, CEP152, ZNF335, PHC1, CDK6, CENPE, SASS6 MFSD2A ANKLE2 and CIT (Khan et al. 2014; Yamamoto et al. 2014; Alakbarzade et al. 2015;Morris-Rosendahl and Kaindl 2015; Basit et al...
June 2017: Journal of Genetics
https://www.readbyqxmd.com/read/28662820/survival-in-parkinson-s-disease-in-relation-to-striatal-dopamine-transporter-binding
#14
Elina Mäkinen, Juho Joutsa, Tero Vahlberg, Valtteri Kaasinen
OBJECTIVE: To investigate whether dopamine transporter (DAT) binding, as measured with single photon emission computed tomography (SPECT), can be used to predict mortality in patients with Parkinson's disease (PD). METHODS: A total of 162 patients with PD and abnormal [I-123]FP-CIT SPECT were clinically followed for a median of 5.8 years. A multivariate Cox regression model was used to investigate survival with the independent predictors of age, gender, severity of motor impairment, levodopa-equivalent daily dose of medication, presence of cognitive defects, and putaminal specific binding ratio (SBR) of [I-123]FP-CIT...
June 23, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28662334/protease-cleavable-linkers-modulate-the-anticancer-activity-of-noninternalizing-antibody-drug-conjugates
#15
Alberto Dal Corso, Samuele Cazzamalli, Rémy Gébleux, Martin Mattarella, Dario Neri
Antibody-drug conjugates (ADCs) represent an attractive class of biopharmaceutical agents, with the potential to selectively deliver potent cytotoxic agents to tumors. It is generally assumed that ADC products should preferably bind and internalize into cancer cells in order to liberate their toxic payload, but a growing body of evidence indicates that also ADCs based on noninternalizing antibodies may be potently active. In this Communication, we investigated dipeptide-based linkers (frequently used for internalizing ADC products) in the context of the noninternalizing F16 antibody, specific to a splice isoform of tenascin-C...
July 6, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28655626/differential-effects-of-perinatal-exposure-to-antidepressants-on-learning-and-memory-acoustic-startle-anxiety-and-open-field-activity-in-sprague-dawley-rats
#16
Jenna L N Sprowles, Jillian R Hufgard, Arnold Gutierrez, Rebecca A Bailey, Sarah A Jablonski, Michael T Williams, Charles V Vorhees
Most antidepressants inhibit monoamine reuptake. Selective serotonin (5-HT) reuptake inhibitors (SSRIs) act on the 5-HT transporter (SERT) whereas norepinephrine-dopamine reuptake inhibitors (NDRIs) act on the norepinephrine and dopamine transporters. Epidemiological reports link SSRI use during pregnancy to an increased prevalence of autism spectrum disorder (ASD). We previously showed that perinatal exposure to the SSRI citalopram (CIT) results in rodent offspring that exhibit a number of behaviors consistent with an ASD-like phenotype...
June 24, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28648577/impact-of-cap-assisted-colonoscopy-on-learning-curve-and-quality-in-colonoscopy-a-randomized-controlled-trial
#17
Zhouwen Tang, Daniel S Zhang, Aaron P Thrift, Kalpesh K Patel
BACKGROUND AND AIMS: Colonoscopy competency assessment in trainees have traditionally been informal. Comprehensive metrics such as the Assessment of Competency in Endoscopy (ACE) tool suggest competency thresholds are higher than assumed. cap-assisted colonoscopy (CAC) may improve competency but data in novice trainees are lacking. We compare CAC versus standard colonoscopy (SC) among novice trainees in a randomized controlled trial. METHODS: All colonoscopies performed by 3 gastroenterology fellows without prior experience were eligible for enrollment...
June 22, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28646738/the-effect-of-soil-properties-on-the-toxicity-and-bioaccumulation-of-ag-nanoparticles-and-ag-ions-in-enchytraeus-crypticus
#18
Emel Topuz, Cornelis A M van Gestel
Standard natural Lufa soils (2.2, 2.3 and 5M) with different organic carbon contents (0.67-1.61%) and pHCaCl2 (5.5-7.3) were spiked with ionic Ag (AgNO3) and polyvinyl pyrrolidone (AgNP-PVP) and citrate (AgNP-Cit) coated Ag nanoparticles (NPs). Enchytraeus crypticus were exposed for 21 days to assess effects on survival and reproduction. Soil, pore water and animals were analyzed for Ag. AgNP-Cit had a strong increasing effect on soil pH, leading to high enchytraeid mortality at concentrations higher than 60-100mg Ag/kg dry soil which made it impossible to determine the influence of soil properties on its toxicity...
June 22, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28645467/citreoviridin-induces-triglyceride-accumulation-in-hepatocytes-through-inhibiting-ppar-%C3%AE-in%C3%A2-vivo-and-in%C3%A2-vitro
#19
Chang Feng, Dandan Li, Liping Jiang, Xiaofang Liu, Qiujuan Li, Chengyan Geng, Xiance Sun, Guang Yang, Xiaofeng Yao, Min Chen
Citreoviridin (CIT) is a mycotoxin produced by Penicillum citreonigrum, Aspergillus terreus and Eupenicillium ochrosalmoneum. CIT occurs naturally in moldy rice and corn. CIT is associated with the development of atherosclerosis in the general population. Alteration in hepatic lipid metabolism is a pathogenic factor in atherosclerosis. However the effect and the underlying mechanism of CIT on hepatic lipid metabolism are largely unknown. In this study, we reported that CIT induced triglyceride accumulation in mice liver and human liver HepG2 cells as shown in oil red O staining...
June 21, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28644992/surface-coating-modulated-toxic-responses-to-silver-nanoparticles-in-wolffia-globosa
#20
Xiaoyan Zou, Penghui Li, Jie Lou, Hongwu Zhang
With the omnipresence of silver nanoparticles (AgNPs) in our daily consumer products, their release has raised serious concerns. However, the biochemical mechanisms by which plants counteract the toxicity of nanoparticles are largely unknown. This study investigated the exposure of aquatic Wolffia globosa to ATP-nAg (AgNPs coated with adenosine triphosphate), cit-nAg (AgNPs coated with citrate), and Ag(+). Hill reaction activity was basically lost in W. globosa treated with 10mg/L ATP-nAg and Ag(+), while the activity was still maintained at 38...
June 15, 2017: Aquatic Toxicology
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