keyword
MENU ▼
Read by QxMD icon Read
search

CIT

keyword
https://www.readbyqxmd.com/read/28098230/molecular-mechanism-of-the-allosteric-regulation-of-the-%C3%AE-%C3%AE-heterodimer-of-human-nad-dependent-isocitrate-dehydrogenase
#1
Tengfei Ma, Yingjie Peng, Wei Huang, Jianping Ding
Human NAD-dependent isocitrate dehydrogenase catalyzes the decarboxylation of isocitrate (ICT) into α-ketoglutarate in the Krebs cycle. It exists as the α2βγ heterotetramer composed of the αβ and αγ heterodimers. Previously, we have demonstrated biochemically that the α2βγ heterotetramer and αγ heterodimer can be allosterically activated by citrate (CIT) and ADP. In this work, we report the crystal structures of the αγ heterodimer with the γ subunit bound without or with different activators...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28088950/-risk-factors-for-acute-rejection-in-living-donor-kidney-transplant-recipients-in-china-a-subgroup-analysis-of-a-multi-center-registry-study
#2
X P Hu, Y Tian, T Y Zhu, J H Chen, C X Wang, X T Li, W J Xue, T Lin, L K Peng, J M Tan, G W Feng, Z S Chen, W K Han, J Dong, Y Fan, X D Zhang
Objective: To evaluate pre-and early post-transplantation risk factors for acute rejection(AR) in kidney recipients. Methods: This subgroup analysis of a multi-center registry study was conducted on living-donor kidney transplant recipients in China with 10 years of follow-up. This study analyzed 1 255 recipients including 921 males(73.4%) and with a mean age of (33±10)years. Data from patients were first analyzed with univariate analysis and then multivariate analysis was used for finding out the potential risk factors of AR...
January 10, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28077270/instructions-to-suppress-semantic-memory-enhances-or-has-no-effect-on-p300-in-a-concealed-information-test-cit
#3
J Peter Rosenfeld, Anne Ward, Jesse Drapekin, Elena Labkovsky, Samuel Tullman
The present study investigated the extent to which people can suppress semantic memory as indexed with the P300 ERP and the autobiographical implicit association test (aIAT). In EXP 1, participants (22) were run in a counterbalanced repeated measures study in both simply knowledgeable (SK) and knowledgeable with suppression (SP) conditions. A P300-based, concealed information test ("Complex Trial Protocol"; CTP) with a 50/50 Target/Nontarget (T/NT) ratio was given both with and without instructions to suppress semantic memories...
January 7, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28047250/we-ab-207a-06-progressive-dose-control-for-cone-beam-ct-with-deformation-assisted-temporal-nonlocal-means-method
#4
L Chen, C Shen, J Wang, S Jiang, X Jia
PURPOSE: To reduce cone beam CT (CBCT) imaging dose, we previously proposed a progressive dose control (PDC) scheme to employ temporal correlation between CBCT images at different fractions for image quality enhancement. A temporal non-local means (TNLM) method was developed to enhance quality of a new low-dose CBCT using existing high-quality CBCT. To enhance a voxel value, the TNLM method searches for similar voxels in a window. Due to patient deformation among the two CBCTs, a large searching window was required, reducing image quality and computational efficiency...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043699/effect-of-phosphate-buffer-on-aggregation-kinetics-of-citrate-coated-silver-nanoparticles-induced-by-monovalent-and-divalent-electrolytes
#5
K Afshinnia, M Baalousha
The attachment efficiency (α) is an important parameter that can be used to characterize nanoparticle (NPs) aggregation behavior and has been a topic of discussion of several papers in the past few years. The importance of α is because it is one of the key parameters that can be used to model NP environmental fate and behavior. This study uses UV-vis and laser Doppler electrophoresis to monitor the aggregation behavior of citrate-coated silver nanoparticles (cit-AgNPs) induced by Na(+) and Ca(2+) as counter ions in the presence and absence of Suwannee River fulvic acid (SRFA) as a surrogate of natural organic matter and different concentrations of phosphate buffer (0-1mM)...
December 30, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/28041833/x-ray-structure-based-evaluation-of-analogs-of-citalopram-compounds-with-increased-affinity-and-selectivity-compared-with-r-citalopram-for-the-allosteric-site-s2-on-hsert
#6
Sid Topiol, Benny Bang-Andersen, Connie Sanchez, Per Plenge, Claus J Loland, Karsten Juhl, Krestian Larsen, Peter Bregnedal, Klaus P Bøgesø
The recent publication of X-ray structures of SERT includes structures with the potent antidepressant S-Citalopram (S-Cit). Earlier predictions of ligand binding at both a primary (S1) and an allosteric modulator site (S2), were confirmed. We provide herein examples of a series of Citalopram analogs, showing distinct structure-activity relationship (SAR) at both sites that is independent of the SAR at the other site. Analogs with a higher affinity and selectivity than benchmark R-Citalopram (R-Cit) for the S2 versus the S1 site were identified...
December 21, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28039431/data-integration-in-physiology-using-bayes-rule-and-minimum-bayes-factors-deubiquitylating-enzymes-in-the-renal-collecting-duct
#7
Zhe Xue, Jia-Xu Chen, Yue Zhao, Barbara Medvar, Mark A Knepper
A major challenge in physiology is to exploit the many large-scale datasets available from "-omic" studies in order to seek answers to key physiological questions. In previous studies, Bayes' Theorem has been used for this purpose. This approach requires a means to map continuously distributed experimental data to probabilities (likelihood values) in order to derive posterior probabilities from the combination of prior probabilities and new data. Here, we introduce the use of Minimum Bayes' Factors for this purpose and illustrate the approach by addressing a physiological question, "Which deubiquitylating enzymes (DUBs) encoded by mammalian genomes are most likely to regulate plasma membrane transport processes in renal cortical collecting duct principal cells?" To do this, we have created a comprehensive online database of 110 DUBs present in the mammalian genome (https://hpcwebapps...
December 30, 2016: Physiological Genomics
https://www.readbyqxmd.com/read/28029437/the-nature-and-extent-of-police-use-of-force-in-encounters-with-people-with-behavioral-health-disorders
#8
Melissa S Morabito, Kelly Socia, Amanda Wik, William H Fisher
Previous research studies have examined the treatment of people with mental illnesses by the police. Much available data support the adoption of the Crisis Intervention Team (CIT) model. A key issue in CIT development has been reduction in the use of force by CIT officers, and it is suggested that such adoption does accomplish such reduction. However, to date, scant research compares variation in police use of force by CIT officers across populations with mental illnesses, co-occurring disorders, and substance abuse disorders, as compared to their non-disordered peers...
October 28, 2016: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/28024811/revealing-the-complex-effects-of-salinity-on-copper-toxicity-in-an-estuarine-clam-potamocorbula-laevis-with-a-toxicokinetic-toxicodynamic-model
#9
Wen-Qian Chen, Wen-Xiong Wang, Qiao-Guo Tan
The effects of salinity on metal toxicity are complex: not only affecting metal bioaccumulation, but also altering the physiology and sensitivity of organisms. In this study, we used a toxicokinetic-toxicodynamic (TK-TD) model to separate and quantify the dual effects of salinity on copper (Cu) toxicity in a euryhaline clam Potamocorbula laevis. The toxicokinetics of Cu was determined using the stable isotope (65)Cu as a tracer at concentrations (10-500 μg L(-1)) realistic to contaminated environments and at salinities ranging from 5 to 30...
December 23, 2016: Environmental Pollution
https://www.readbyqxmd.com/read/28012421/distribution-of-tetracycline-resistance-genes-and-ampc-%C3%AE-lactamase-genes-in-representative-non-urban-sewage-plants-and-correlations-with-treatment-processes-and-heavy-metals
#10
Yan-Bin Xu, Mao-Yu Hou, Ya-Fei Li, Lu Huang, Jing-Jing Ruan, Li Zheng, Qing-Xia Qiao, Qing-Ping Du
The mixed development of livestock breeding and industry in non-urban zones is a very general phenomenon in China. Distribution of antibiotic resistance genes (ARGs) in non-urban sewage treatment systems has not been paid enough attentions. In this study, eleven tetracycline resistance genes (tetA, tetB, tetC, tetE, tetG, tetL, tetM, tetO, tetQ, tetS and tetX), four AmpC β-lactamase genes (EBC, MOX, FOX and CIT) and four heavy metals (Cu, Zn, Cd and Pb) were detected and analyzed in four non-urban sewage plants with different sewage sources and different treatment processes in Guangzhou...
December 9, 2016: Chemosphere
https://www.readbyqxmd.com/read/28002483/physical-characteristics-of-a-citrullinated-pro-filaggrin-epitope-recognized-by-anti-citrullinated-protein-antibodies-in-rheumatoid-arthritis-sera
#11
Nicole Hartwig Trier, Bettina Eide Holm, Ole Slot, Henning Locht, Hanne Lindegaard, Anders Svendsen, Gunnar Houen
Rheumatoid arthritis (RA) is an autoimmune disease of complex etiology. A characteristic feature of a subset of RA is the presence of anti-citrullinated protein antibodies (ACPA), which correlate with a progressive disease course. In this study, we employed streptavidin capture enzyme-linked immunosorbent assay to analyze ACPA reactivity. Using the pro-filaggrin peptide HQCHQEST-Cit-GRSRGRCGRSGS, as template, we analyzed the reactivity of RA sera and healthy donor sera to various peptides in order to determine the physical characteristics of the citrullinated pro-filaggrin epitope and to examine whether biotin labelling influence antibody recognition...
2016: PloS One
https://www.readbyqxmd.com/read/27999534/striatal-dopaminergic-innervation-regulates-subthalamic-beta-oscillations-and-cortical-subcortical-coupling-during-movements-preliminary-evidence-in-subjects-with-parkinson-s-disease
#12
Andrea Canessa, Nicolò G Pozzi, Gabriele Arnulfo, Joachim Brumberg, Martin M Reich, Gianni Pezzoli, Maria F Ghilardi, Cordula Matthies, Frank Steigerwald, Jens Volkmann, Ioannis U Isaias
Activation of the basal ganglia has been shown during the preparation and execution of movement. However, the functional interaction of cortical and subcortical brain areas during movement and the relative contribution of dopaminergic striatal innervation remains unclear. We recorded local field potential (LFP) activity from the subthalamic nucleus (STN) and high-density electroencephalography (EEG) signals in four patients with Parkinson's disease (PD) off dopaminergic medication during a multi-joint motor task performed with their dominant and non-dominant hand...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27995107/evaluating-the-effectiveness-of-adding-magnesium-chloride-to-conventional-protocol-of-citrate-alkali-therapy-on-kidney-stone-size
#13
Hassan Niroomand, Amin Ziaee, Keivan Ziaee, Alaleh Gheissari
BACKGROUND: Potassium citrate (K-Cit) is one of the therapeutic solutions broadly used in patients with urolithiasis. However, recent studies have shown that it is not so effective. Therefore, the goal of our study was to evaluate the effect of a combination of K-Cit - MgCl2 oral supplements, on urinary stone size. MATERIALS AND METHODS: This study was performed on 70 asymptomatic urolithiasis cases. The supplements included K-Cit and magnesium chloride (MgCl2), purchased from (Merck Company, Germany)...
2016: Advanced Biomedical Research
https://www.readbyqxmd.com/read/27974320/from-20th-century-metabolic-wall-charts-to-21st-century-systems-biology-database-of-mammalian-metabolic-enzymes
#14
Callan C Corcoran, Cameron R Grady, Trairak Pisitkun, Jaya Parulekar, Mark A Knepper
The organization of the mammalian genome into gene subsets corresponding to specific functional classes has provided key tools for systems biology research. Here, we have created a web-accessible resource called the Mammalian Metabolic Enzyme Database (https://hpcwebapps.cit.nih.gov/ESBL/Database/MetabolicEnzymes/MetabolicEnzymeDatabase.html) keyed to the biochemical reactions represented on iconic metabolic pathway wall charts created in the previous century. Overall, we have mapped 1647 genes to these pathways, representing approximately 7 percent of the protein-coding genome...
December 14, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27941527/striatal-dopamine-transporter-modulation-after-rotigotine-results-from-a-pilot-single-photon-emission-computed-tomography-study-in-a-group-of-early-stage-parkinson-disease-patients
#15
Carlo Rossi, Dario Genovesi, Paolo Marzullo, Assuero Giorgetti, Elena Filidei, Giovanni Umberto Corsini, Ubaldo Bonuccelli, Roberto Ceravolo
INTRODUCTION: Several in vitro data have reported negative interference by dopamine-agonists on the expression of dopamine transporter (DAT), whereas the majority of imaging studies have shown that neither L-dopa nor dopamine-agonists interfere with DAT availability. As yet, there are no in vivo studies on DAT expression after treatment with rotigotine. METHODS: We evaluated presynaptic nigrostriatal function in 8 patients with de novo Parkinson disease (age, 59 ± 6...
January 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/27941373/added-value-of-combined-semi-quantitative-and-visual-123i-fp-cit-spect-analyses-for-the-diagnosis-of-dementia-with-lewy-bodies
#16
Nicolas Nicastro, Valentina Garibotto, Gilles Allali, Frederic Assal, Pierre R Burkhard
PURPOSE OF THE REPORT: To assess the validity of a semi-quantitative I-FP-CIT SPECT method, compared to the commonly used visual analysis, in patients with probable dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). We also studied DLB specific uptake impairment pattern and correlation of uptake in the presence or absence of parkinsonism. MATERIALS AND METHODS: Among 1202 scans performed at our center from 2003 to 2015, we identified 93 subjects with probable DLB (mean age 76...
December 9, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27940650/autopsy-validation-of-123i-fp-cit-dopaminergic-neuroimaging-for-the-diagnosis-of-dlb
#17
Alan J Thomas, Johannes Attems, Sean J Colloby, John T O'Brien, Ian McKeith, Rodney Walker, Lean Lee, David Burn, Debra J Lett, Zuzana Walker
OBJECTIVE: To conduct a validation study of (123)I-N-fluoropropyl-2b-carbomethoxy-3b-(4-iodophenyl) nortropane ((123)I-FP-CIT) SPECT dopaminergic imaging in the clinical diagnosis of dementia with Lewy bodies (DLB) with autopsy as the gold standard. METHODS: Patients >60 years of age with dementia who had undergone (123)I-FP-CIT imaging in research studies and who had donated their brain tissue to the Newcastle Brain Tissue Resource were included. All had structured clinical research assessments, and clinical diagnoses were applied by consensus panels using international diagnostic criteria...
December 9, 2016: Neurology
https://www.readbyqxmd.com/read/27936859/extracting-critical-information-from-group-members-partial-knowledge-using-the-searching-concealed-information-test
#18
Eitan Elaad
The Concealed Information Test (CIT) is a psychophysiological method designed to detect information that an individual cannot or does not wish to reveal. The present study used a version of the CIT, the Searching Concealed Information Test (SCIT), to extract information from partial information that participants possessed on a planned jailbreak. In the first experiment, 52 undergraduate students were randomly, but not equally, allocated into 15 different clusters of partial knowledge. In each, participants possessed knowledge about 2 of 6 critical items...
December 2016: Journal of Experimental Psychology. Applied
https://www.readbyqxmd.com/read/27928483/emergence-of-cmy-2-and-dha-1-type-ampc-%C3%AE-lactamases-in-enterobacter-cloacae-isolated-from-several-hospitals-of-qazvin-and-tehran-iran
#19
Amir Peymani, Taghi Naserpour-Farivar, Moein Yeylagh-Beygi, Shahiin Bolori
BACKGROUND AND OBJECTIVES: The emergence of plasmid-mediated AmpC (pAmpC) β-lactamases conferring resistance to third-generation cephalosporins has become a major clinical concern worldwide. The aims of this study were to determine the prevalence of pAmpC-producing E. cloacae isolates and typing of them in Qazvin and Tehran provinces, Iran. MATERIALS AND METHODS: A total of 120 cefoxitin non-susceptible isolates of E. cloacae were obtained from educational hospitals of Qazvin and Tehran, Iran...
June 2016: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/27924714/biomonitoring-of-mycotoxins-in-urine-pilot-study-in-mill-workers
#20
Wolfram Föllmann, Nurshad Ali, Meinolf Blaszkewicz, Gisela H Degen
Contamination of grains with mycotoxins results in a dietary background exposure of the general population. In occupational settings such as during processing of raw materials as in milling, an additional mycotoxin exposure by inhalation is possible. Biomonitoring is an integrative approach to assess human exposure from various sources and by all routes. To investigate possible workplace exposure to mycotoxins, a pilot study was conducted that compared levels of urinary biomarkers in mill workers to those in a control group with dietary mycotoxin intake alone...
2016: Journal of Toxicology and Environmental Health. Part A
keyword
keyword
95491
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"