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https://www.readbyqxmd.com/read/29678229/the-use-of-serological-tests-in-combination-with-the-intradermal-tuberculin-test-maximizes-the-detection-of-tuberculosis-infected-goats
#1
Javier Bezos, Álvaro Roy, José Antonio Infantes-Lorenzo, Isabel González, Ángel Venteo, Beatriz Romero, Anna Grau, Olga Mínguez, Lucas Domínguez, Lucía de Juan
The diagnosis of tuberculosis (TB) in goats is based mainly on the single and comparative intradermal tuberculin (SIT and CIT) tests and, exceptionally, on the interferon-gamma (IFN-γ) assay, however they are not perfect in terms of sensitivity and specificity. Nevertheless, various serological assays that provide a potential cost-effective approach for the control of TB are also available or under development, and a variety of results have been reported regarding the ability of these tests to detect infected animals, particularly in the early stages of infection...
May 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29673704/synergistic-action-of-the-nephrotoxic-mycotoxins-ochratoxin-a-and-citrinin-at-nanomolar-concentrations-in-human-proximal-tubule-derived-cells
#2
Marie-Christin Schulz, Luise Schumann, Ulrike Rottkord, Hans-Ulrich Humpf, Michael Gekle, Gerald Schwerdt
Increased ochratoxin A (OTA) or citrinin (CIT) concentrations in food correlate with increased prevalence of tubule-interstitial nephropathy. We tested the hypothesis that co-exposure of human proximal tubule-derived epithelial cells (HK-2) to OTA and CIT promotes synergistic events indicative for inflammation, epithelial-to-mesenchymal-transition (EMT) or fibrosis. We measured markers of inflammation, EMT and fibrosis and investigated the role of MAP-kinases. Only concurrent but not individual exposure to OTA and CIT at nanomolar concentrations led to (i) an increase of TNF protein and mRNA, (ii) a decrease of COX-2 protein and mRNA, (iii) a decrease of E-cadherin protein and (iv) an increase of vimentin and α-SMA protein...
April 16, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29673593/augmented-neutrophil-extracellular-traps-formation-promotes-atherosclerosis-development-in-socially-defeated-apoe-mice
#3
Keita Yamamoto, Hiroyuki Yamada, Noriyuki Wakana, Masakazu Kikai, Kensuke Terada, Naotoshi Wada, Shinichiro Motoyama, Makoto Saburi, Takeshi Sugimoto, Daisuke Kami, Takehiro Ogata, Masakazu Ibi, Chihiro Yabe-Nishimura, Satoaki Matoba
Depression is an independent risk factor of cardiovascular disease (CVD); however, the causal association remains undefined. We exposed mice to repeated social defeat (RSD) to precipitate depressive-like behaviors, and investigated the effects on atherosclerosis. Eight-week-old male apoE-/- mice were exposed to RSD by housing with a larger CD-1 mouse in a shared home cage. They were subjected to vigorous physical contact daily for 10 consecutive days and fed a high-cholesterol diet (HCD) for 6 weeks. The social interaction ratio and immobility time showed dramatic social avoidance before and after HCD feeding...
April 16, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29671940/a-long-term-prospective-cohort-study-on-immediately-restored-single-tooth-implants-inserted-in-extraction-sockets-and-healed-ridges-cbct-analyses-soft-tissue-alterations-aesthetic-ratings-and-patient-reported-outcomes
#4
Stefanie Raes, Aryan Eghbali, Vivianne Chappuis, Filiep Raes, Hugo De Bruyn, Jan Cosyn
BACKGROUND: Although many studies have been published on single implants, long-term data remain scarce. PURPOSE: To evaluate immediately restored single implants after at least 8 years of follow-up in terms of buccal bone, soft tissue alterations, aesthetic ratings, and patient-reported outcomes. MATERIALS AND METHODS: This prospective cohort study included patients who were consecutively treated with an immediately restored single implant installed in an extraction socket (IIT) or a healed ridge (CIT) in the anterior maxilla...
April 19, 2018: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/29669609/neuropsychological-test-performance-in-parkinsonism-without-dopaminergic-deficiency-on-123i-fp-cit-spect-imaging
#5
Kathryn A Wyman-Chick, Phillip K Martin, Michal Minár, Manuel Menéndez-González, Lauren O Erickson, Tania Álvarez-Avellón, Ryan W Schroeder
OBJECTIVES: To examine neuropsychological test performance among individuals clinically diagnosed with Parkinson's disease (PD) without evidence of dopaminergic deficiency on [123]I-CIT single photon emission computed tomography imaging. METHODS: Data were obtained from the Parkinson's Progression Marker Initiative. The sample included 59 participants with scans without evidence of dopaminergic deficiency (SWEDD), 412 with PD, and 114 healthy controls (HC). Tests included Judgment of Line Orientation, Letter-Number Sequencing, Symbol Digit Modalities, Hopkins Verbal Learning Test-Revised, and Letter and Category Fluency...
April 19, 2018: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29666579/d-dencichine-regulates-thrombopoiesis-by-promoting-megakaryocyte-adhesion-migration-and-proplatelet-formation
#6
Shilan Ding, Min Wang, Song Fang, Huibo Xu, Huiting Fan, Yu Tian, Yadong Zhai, Shan Lu, Xin Qi, Fei Wei, Guibo Sun, Xiaobo Sun
Life-threatening chemotherapy-induced thrombocytopenia can increase the risk of bleeding due to a dramatic low platelet count, which may limit or delay treatment schedules in cancer patients. The pressing need for the rapid alleviation of the symptoms of thrombocytopenia has prompted us to search for novel highly effective and safe thrombopoietic agents. Pharmacological investigations have indicated that dencichine can prevent and treat blood loss and increase the number of platelets. On the basis of the neurotoxicity of dencichine, D-dencichine is artificially synthesized in the laboratory...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29665043/the-act-of-answering-questions-elicited-differentiated-responses-in-a-concealed-information-test
#7
Takuro Otsuka, Mitsuyoshi Mizutani, Akihiro Yagi, Jun'ichi Katayama
The concealed information test (CIT), a psychophysiological detection of deception test, compares physiological responses between crime-related and crime-unrelated items. In previous studies, whether the act of answering questions affected physiological responses was unclear. This study examined effects of both question-related and answer-related processes on physiological responses. Twenty participants received a modified CIT, in which the interval between presentation of questions and answering them was 27 s...
April 17, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29664688/predictive-value-of-cd4-cd8-ratio-in-patients-with-breast-cancer-receiving-recombinant-human-thrombopoietin
#8
Junnan Xu, Lei Jiang, Hui Cao, Yufeng Jia, Shuo Wu, Cui Jiang, Tao Sun
Recombinant human thrombopoietin (rhTPO) is a key determinant of therapy for chemotherapy-induced thrombocytopenia (CIT) in patients with breast cancer. To assess the predictive value of preoperative inflammatory cells for response to rhTPO in breast cancer patients, a total of 198 female patients with breast cancer were enrolled between June 2011 and December 2016 in Liaoning Cancer Hospital. Peripheral blood samples before rhTPO therapy were obtained, the ratios of helper T cell (CD4+ ), cytotoxic T cell (CD8+ ), NK cell (CD16+ /CD56+ ), and B cell (CD19+ ) were analyzed, and CD4/CD8 ratios were calculated...
April 17, 2018: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/29661737/a-rapid-triage-protocol-to-optimize-cold-ischemic-time-for-breast-resection-specimens
#9
Ellen G East, Matthew Gabbeart, Emily Roberts, Lili Zhao, Julie M Jorns
Prolonged time from specimen excision to adequate formalin exposure, or cold ischemic time (CIT), negatively impacts estrogen receptor (ER), progesterone receptor (PR) and HER-2 biomarker studies routinely performed on breast specimens. Current guidelines recommend CIT of ≤1 h. Since formalin penetrates resections slowly, optimal fixation requires incision. We evaluated the efficacy of a rapid triage protocol developed to optimize CIT. We identified 2821 specimens: 650 (23.0%) excisional biopsies (EB), 1051 (37...
March 6, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29661421/liver-transplantation-using-prolonged-cold-ischemia-time-grafts-preserved-with-institute-george-lopez-1-solution
#10
J C Wiederkehr, M R Igreja, N Gonçalves, M Nogara, M Godoy, C Drago, A M Massutti, H A Wiederkehr, B A Wiederkehr
Institute George-Lopez-1 (IGL-1) solution is a preservation solution with lower potassium and lower viscosity than the University of Wisconsin solution that has been recently used in liver transplantation. In the present series, we compare the outcome of liver grafts from brain-dead donors preserved in IGL-1cold storage solution, with cold ischemia times (CITs) longer than 8 hours and those less than 8 hours. Two hundred fifty-two liver transplantations performed from January 2014 to December 2016 at Hospital Santa Isabel, Blumenau, Brazil, were retrospectively analyzed...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29656429/citalopram-attenuated-neurobehavioral-biochemical-and-metabolic-alterations-in-transient-middle-cerebral-artery-occlusion-model-of-stroke-in-male-wistar-rats
#11
Sangeetha Gupta, Deepti Upadhayay, Uma Sharma, Naranamangalam R Jagannathan, Yogendra Kumar Gupta
Oxidative stress and inflammation are implicated as cardinal mechanisms of neuronal death following stroke. In the present study citalopram (Cit) was investigated in a 2 h middle cerebral artery occlusion (MCAo) model of stroke in male Wistar rats. Pretreatment, posttreatment (Post Cit) and pre plus posttreatment (Pre + Post Cit) with Cit were evaluated for its neuroprotective effect. In pretreatment protocol, effect of Cit at three doses (2, 4, and 8 mg/kg) administered i.p., 1 h prior to MCAo was evaluated using neurological deficit score (NDS), motor deficit paradigms, and cerebral infarction 24 h post-MCAo...
April 15, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29656176/underreporting-of-fatal-poisonings-in-brazil-a-descriptive-study-using-data-from-four-information-systems
#12
Andrea Franco Amoras Magalhães, Eloisa Dutra Caldas
Poisoning is a worldwide problem that involves individuals of all ages and a range of chemicals. In this study, fatal poisoning cases that occurred in the Federal District of Brazil (DF) from 2009 to 2013 were described using information from four systems, and the reasons for underreporting of each system were discussed. Data were obtained from the mortality information system (SIM), the notifiable disease information system (SINAN), the poison information center (CIT), and the forensic medicine institute (IML) of the DF...
April 4, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29651376/synthesis-characterization-and-application-of-lipase-conjugated-citric-acid-coated-magnetic-nanoparticles-for-ester-synthesis-using-waste-frying-oil
#13
Unisha Patel, Kishor Chauhan, Shilpa Gupte
In the present work, magnetic nanoparticles (MNPs) were prepared by chemical precipitation of trivalent and divalent iron ions which were functionalized using citric acid. The bacterial isolate Staphylococcus epidermidis KX781317 was isolated from oil-contaminated site. The isolate produced lipase, which was purified and immobilized on magnetic nanoparticles (MNPs) for ester synthesis from waste frying oil (WFO). The characterization of MNPs employed conventional TEM, XRD and FTIR techniques. TEM analysis of MNPs showed the particle size in the range of 20-50 nm...
April 2018: 3 Biotech
https://www.readbyqxmd.com/read/29651282/effect-of-cinnamaldehyde-and-citral-combination-on-transcriptional-profile-growth-oxidative-damage-and-patulin-biosynthesis-of-penicillium-expansum
#14
Yuan Wang, Kewei Feng, Haihua Yang, Zhiwei Zhang, Yahong Yuan, Tianli Yue
Penicillium expansum , as a main postharvest pathogen of fruits, can secrete patulin (PAT), causing fruit decay and health problems. In this study, the antifungal test, SEM (scanning electron microscope) observation, transcriptional profile, PAT biosynthesis, and physiological characters of P. expansum exposed to cinnamaldehyde and citral combination (Cin/Cit) were evaluated. Cin/Cit could inhibit the mycelial growth and spore germination of P. expansum in a dose-dependent manner. Besides, Cin/Cit caused spores and mycelia wrinkled and depressed by SEM observation...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29648856/treatment-expectancy-and-working-alliance-in-pharmacotherapy-as-predictors-of-outcomes-in-complicated-grief
#15
Elizabeth M Goetter, Christine M Mauro, Xin Qiu, Natalia A Skritskaya, Charles F Reynolds, Sidney Zisook, M Katherine Shear, Naomi M Simon
OBJECTIVE: Nonspecific factors, such as treatment outcome expectancy and working alliance, can influence treatment outcome. No studies to date have examined the role of expectancy and alliance on pharmacotherapy outcomes in individuals with complicated grief (CG). METHOD: This secondary analysis of a larger randomized, control trial (RCT) examined the relationship between pharmacotherapy expectancy and alliance on treatment outcome in adults with CG who were participating in a multisite, double-blind, RCT examining the efficacy of citalopram and complicated grief treatment (CGT)...
April 2018: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/29643961/cecal-intubation-rates-in-different-eras-of-endoscopic-technological-development
#16
Maciej Matyja, Artur Pasternak, Mirosław Szura, Michał Pędziwiatr, Piotr Major, Kazimierz Rembiasz
Introduction: Colonoscopy plays a critical role in colorectal cancer (CRC) screening and has been widely regarded as the gold standard. Cecal intubation rate (CIR) is one of the well-defined quality indicators used to assess colonoscopy. Aim: To assess the impact of new technologies on the quality of colonoscopy by assessing completion rates. Material and methods: This was a dual-center study at the 2nd Department of Surgery at Jagiellonian University Medical College and at the Specialist Center "Medicina" in Krakow, Poland...
March 2018: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/29629914/123i-fp-cit-spect-and-mri-findings-in-a-patient-with-parkinsonism-after-fenpyroximate-intoxication
#17
Kyeong Joon Kim, Jong-Min Kim, Yun Jung Bae, Yoo Sung Song, Sang Eun Kim
Fenpyroximate is a widely used acaricide. Its main action is to inhibit the mitochondrial respiratory chain. Chronic exposure to fenpyroximate is associated with dopaminergic cell loss and parkinsonism; however, to date, there has not been a reported case of parkinsonism as a result of acute fenpyroximate intoxication. Here, we report a 58-year-old man who developed parkinsonism after deliberate fenpyroximate intoxication, but with normal presynaptic I-Ioflupane SPECT image.
April 6, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29627202/critical-incident-technique-analysis-applied-to-perianesthetic-cardiac-arrests-at-a-university-teaching-hospital
#18
Erik H Hofmeister, Rachel A Reed, Michele Barletta, Molly Shepard, Jane Quandt
OBJECTIVE: To apply the critical incident technique (CIT) methodology to a series of perianesthetic cardiac arrest events at a university teaching hospital to describe the factors that contributed to cardiac arrest. STUDY DESIGN: CIT qualitative analysis of a case series. ANIMALS: A group of 16 dogs and cats that suffered a perioperative cardiac arrest between November 2013 and November 2016. METHODS: If an arrest occurred, the event was discussed among the anesthesiologists...
January 17, 2018: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29616790/novel-tadalafil-derivatives-ameliorates-scopolamine-induced-cognitive-impairment-in-mice-via-inhibition-of-acetylcholinesterase-ache-and-phosphodiesterase-5-pde5
#19
Wei Ni, Huan Wang, Xiaokang Li, Xinyu Zheng, Manjiong Wang, Jian Zhang, Qi Gong, Dazheng Ling, Fei Mao, Haiyan Zhang, Jian Li
Based on the drugs repositioning and redeveloping strategy, first-generation dual-target inhibitors of acetylcholinesterase (AChE) and phosphodiesterase 5 (PDE5), have been recently reported as a potentially novel therapeutic method for the treatment of Alzheimer's disease (AD), and the lead compound 2 has proven this method was feasible in AD mouse models. In this study, our work focused on exploring alternative novel tadalafil derivatives (3a-s). Among the nineteen analogues, compound 3c exhibited good selective dual-target AChE/PDE5 inhibition, good blood-brain barrier (BBB) permeability...
April 4, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29599639/association-of-well-being-index-and-cognitive-impairment-with-primary-open-angle-glaucoma-patients-of-malaysia-a-case-control-study
#20
Soumendra Sahoo, Thanigasalam Thevi, Htoo Htoo Kyaw Soe
The purpose of this study was to determine the association of well-being and cognitive impairment with primary open angle glaucoma (POAG) patients attending a tertiary care hospital in Malaysia. Fifty-four individuals were recruited for study as cases were matched with 60 individuals as the control subjects, and data were collected using the WHO well-being index and the validated 6-item cognitive impairment test dementia test. The results showed that there was no significant association between gender, ethnicity, socioeconomic status and POAG...
February 2018: Malaysian Journal of Medical Sciences: MJMS
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