keyword
MENU ▼
Read by QxMD icon Read
search

CIT

keyword
https://www.readbyqxmd.com/read/29455437/live-donor-liver-transplantation-for-acute-liver-failure-a-single-center-experience
#1
Siddharth Mehrotra, Naimish Mehta, Prashantha S Rao, Shailendra Lalwani, Vivek Mangla, Samiran Nundy
INTRODUCTION: Acute liver failure (ALF) is an indication for emergency liver transplantation (LT). Although centers performing only deceased donor liver transplants (DDLT) have shown improved outcomes in this situation, they still have relatively long waiting lists. An alternative would be living donor liver transplantation (LDLT), which has shown equivalent outcomes in the elective situation but there is limited evidence of its results in ALF. AIM: The purpose of this study was to assess the outcomes in patients with ALF undergoing emergency LDLT in our center in Delhi, India...
February 17, 2018: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/29454642/moderate-financial-incentive-does-not-appear-to-influence-the-p300-concealed-information-test-cit-effect-in-the-complex-trial-protocol-ctp-version-of-the-cit-in-a-forensic-scenario-while-affecting-p300-peak-latencies-and-behavior
#2
J Peter Rosenfeld, Evan Sitar, Joshua Wasserman, Anne Ward
Previous research indicated that the skin conductance response (SCR) of the Autonomic Nervous System (ANS) in the Concealed Information Test (CIT) is typically increased in subjects who are financially and otherwise incentivized to defeat the CIT (the paradoxical "motivational impairment" effect). This is not the case for RT-based CITs, nor for P300 tests based on the 3-stimulus protocol or Complex Trial Protocol for detection of cognitive malingering (although these are not the same as forensic CITs)...
February 15, 2018: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29452669/optimal-management-of-the-young-patient-cll-patient
#3
REVIEW
John N Allan, Richard R Furman
The emergence of targeted therapy for patients with chronic lymphocytic leukemia (CLL) has permanently altered the therapeutic landscape. In both upfront and relapsed settings, safe and effective oral kinase inhibitors are available which rival the responses and durability seen with standard chemo immunotherapy regimens. In 2016, ibrutinib was granted Federal Drug Administration approval for first-line therapy in patients with CLL. While its role as initial therapy for older, unfit or deleted 17p CLL patients is less controversial, its role as first-line treatment for younger fit patients is less clear, begging the question, what is the optimal treatment for these patients, novel agents or standard CIT strategies? In this review, we aim to provide guidance for what we believe is the optimal management of young fit patients with CLL...
March 2018: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/29449446/improving-accuracy-of-simultaneously-reconstructed-activity-and-attenuation-maps-using-deep-learning
#4
Donghwi Hwang, Kyeong Yun Kim, Seung Kwan Kang, Seongho Seo, Jin Chul Paeng, Dong Soo Lee, Jae Sung Lee
Simultaneous reconstruction of activity and attenuation using the maximum likelihood reconstruction of activity and attenuation (MLAA) augmented by time-of-flight (TOF) information is a promising method for positron emission tomography (PET) attenuation correction. However, it still suffers from several problems, including crosstalk artifacts, slow convergence speed, and noisy attenuation maps (μ-maps). In this work, we developed deep convolutional neural networks (CNNs) to overcome these MLAA limitations, and we verified their feasibility using a clinical brain PET data set...
February 15, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29449184/relation-of-overactive-bladder-with-motor-symptoms-and-dopamine-transporter-imaging-in-drug-na%C3%A3-ve-parkinson-s-disease
#5
Yasunori Mito, Ichiro Yabe, Hiroaki Yaguchi, Toshiki Takei, Satoshi Terae, Yasutaka Tajima
OBJECTIVES: The aim of the present study was to determine the relation of urinary dysfunction with motor symptoms and nigrostriatal neuron loss in drug-naïve patients with Parkinson's disease (PD). We therefore examined the relation of overactive bladder (OAB) symptoms with motor symptoms and striatal dopamine transporter (DAT) binding measured by [123-Iodine]-fluoropropyl-2beta-carbomethoxy-3beta-(4-iodophenylnortropane) dopamine transporter single-photon emission computed tomography (123 I-FP-CIT SPECT)...
February 9, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29440891/ph-responsive-charge-reversal-polymer-functionalized-boron-nitride-nanospheres-for-intracellular-doxorubicin-delivery
#6
Shini Feng, Huijie Zhang, Chunyi Zhi, Xiao-Dong Gao, Hideki Nakanishi
Background: Anticancer drug-delivery systems (DDSs) capable of responding to the physiological stimuli and efficiently releasing drugs inside tumor cells are highly desirable for effective cancer therapy. Herein, pH-responsive, charge-reversal poly(allylamine hydrochlorid)-citraconic anhydride (PAH-cit) functionalized boron nitride nanospheres (BNNS) were fabricated and used as a carrier for the delivery and controlled release of doxorubicin (DOX) into cancer cells. Methods: BNNS was synthesized through a chemical vapor deposition method and then functionalized with synthesized charge-reversal PAH-cit polymer...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29437879/characterizing-the-potency-and-impact-of-carbon-ion-therapy-in-a-primary-mouse-model-of-soft-tissue-sarcoma
#7
Jeremy Michael Brownstein, Amy Jordan Wisdom, Katherine D Castle, Yvonne M Mowery, Peter M Guida, Chang-Lung Lee, Francesco Tommasino, Chiara La Tessa, Emanuele Scifoni, Junheng Gao, Lixia Luo, Lorraine Da Silva Campos, Yan Ma, Nerissa Williams, Sin-Ho Jung, Marco Durante, David G Kirsch
Carbon ion therapy (CIT) offers several potential advantages for treating cancers compared with X-ray and proton radiotherapy including increased biological efficacy and more conformal dosimetry. However, CIT potency has not been characterized in primary tumor animal models. Here, we calculate the relative biological effectiveness (RBE) of carbon ions compared to X-rays in an autochthonous mouse model of soft tissue sarcoma. We used Cre/loxP technology to generate primary sarcomas in KrasLSL-G12D/+; p53fl/fl mice...
February 7, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29433608/brain-stem-serotonin-transporter-availability-in-maternal-uniparental-disomy-and-deletion-prader-willi-syndrome
#8
Rajeev Krishnadas, Sally-Ann Cooper, Alice Nicol, Sally Pimlott, Sarita Soni, Anthony J Holland, Laura McArthur, Jonathan Cavanagh
Prader-Willi syndrome (PWS) is a rare condition because of the deletion of paternal chromosomal material (del PWS), or a maternal uniparental disomy (mUPD PWS), at 15q11-13. Affective psychosis is more prevalent in mUPD PWS. We investigated the relationship between the two PWS genetic variants and brain-stem serotonin transporter (5-HTT) availability in adult humans. Mean brain-stem 5-HTT availability determined by [123I]-beta-CIT single photon emission tomography was lower in eight adults with mUPD PWS compared with nine adults with del PWS (mean difference -0...
January 2018: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29432664/the-impact-of-cold-ischemia-time-cit-at-the-higher-end-of-the-kdpi-spectrum-what-is-the-risk
#9
David D Lee, Hani M Wadei
On December 4, 2014, the new kidney allocation system (KAS) was implemented to reduce extreme longevity mismatches between kidney allograft and recipient life expectancy, increase the highly sensitized patients' access to transplantation through prioritization, broaden access for disadvantaged candidates by counting dialysis time towards wait-list time, and potentially increase the utilization of "marginal kidneys" through broader allocation at the local and regional level. In the first year after implementation, the early results of KAS suggested that the new policies were successful in meeting many of these goals 1 ...
February 12, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29428804/links-between-a-biomarker-profile-cold-ischaemic-time-and-clinical-outcome-following-simultaneous-pancreas-and-kidney-transplantation
#10
Hussein A Khambalia, M Yvonne Alexander, Mahesan Nirmalan, Ria Weston, Phillip Pemberton, Zia Moinuddin, Angela Summers, David van Dellen, Titus Augustine
In sepsis, trauma and major surgery, where an explicit physiological insult leads to a significant systemic inflammatory response, the acute evolution of biomarkers have been delineated. In these settings, Interleukin (IL) -6 and TNF-α are often the first pro-inflammatory markers to rise, stimulating production of acute phase proteins followed by peaks in anti-inflammatory markers. Patients undergoing SPKT as a result of diabetic complications already have an inflammatory phenotype as a result of uraemia and glycaemia...
February 8, 2018: Cytokine
https://www.readbyqxmd.com/read/29422337/depressed-and-non-depressed-mothers-touching-during-social-interactions-with-their-infants
#11
Irene Mantis, Marisa Mercuri, Dale M Stack, Tiffany M Field
Touch is a critical channel of communication used by mothers to communicate and interact with their infants and to contribute to their infants' socio-emotional development. The present study examined maternal touching in 41 mothers with and without depressive symptomatology. Mothers and their 4-month-old infants participated in the Still-Face (maternal emotional unavailability) and Separation (maternal physical unavailability) procedures. Maternal touching behaviours were video-recorded and coded using the Caregiver Infant Touch Scale (CITS)...
February 2, 2018: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29421354/risk-management-of-ochratoxigenic-fungi-and-ochratoxin-a-in-maize-grains-by-bioactive-evoh-films-containing-individual-components-of-some-essential-oils
#12
Andrea Tarazona, José V Gómez, Rafael Gavara, Rufino Mateo-Castro, José V Gimeno-Adelantado, Misericordia Jiménez, Eva M Mateo
Aspergillus steynii and Aspergillus tubingensis are possibly the main ochratoxin A (OTA) producing species in Aspergillus section Circumdati and section Nigri, respectively. OTA is a potent nephrotoxic, teratogenic, embryotoxic, genotoxic, neurotoxic, carcinogenic and immunosuppressive compound being cereals the first source of OTA in the diet. In this study bioactive ethylene-vinyl alcohol copolymer (EVOH) films containing cinnamaldehyde (CINHO), linalool (LIN), isoeugenol (IEG) or citral (CIT) which are major components of some plant essential oils (EOs) were produced and tested against A...
February 3, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29420890/an-immunoblotting-quantification-approach-for-identifying-potential-hypoallergenic-citrus-cultivars
#13
Jinlong Wu, Wenjun Deng, Dingbo Lin, Xiuxin Deng, Zhaocheng Ma
The inherent allergens of citrus fruits, such as Cit s 1, Cit s 2, Cit s 3 can cause allergic reactions. A better understanding of the genetic factors (cultivar to cultivar) affecting the allergenic potential of citrus fruits would be beneficial for further identification of hypoallergenic genotypes. In the present study, an immunoblotting quantification approach was adopted to assess the potential allergenicity of 21 citrus cultivars, including nine subgroups (tangerine, satsuma, orange, pummelo, grapefruit, lemon, kumquat, tangor and tangelo)...
February 8, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29415069/administration-of-l-arginine-plus-l-citrulline-or-l-citrulline-alone-successfully-retarded-endothelial-senescence
#14
Tomoe Tsuboi, Morihiko Maeda, Toshio Hayashi
L-citrulline and L-arginine supplementation has been shown to have several beneficial effects on the cardiovascular system. Nitric oxide (NO) protects against the progression of atherosclerosis and is synthesized by nitric oxide synthase (NOS), which converts L-arginine (L-Arg) into L-citrulline (L-Cit). Our previous study revealed that chronic administration of a combination of L-Cit and L- Arg has a better therapeutic effect on high cholesterol-induced atherosclerosis in rabbits. We investigated how L-Arg and L-Cit affect endothelial function, aging and atherosclerosis...
2018: PloS One
https://www.readbyqxmd.com/read/29414568/influence-of-ligand-chemistry-on-silver-nanoparticles-for-colorimetric-detection-of-cr3-and-hg2-ions
#15
Suresh Kumar Kailasa, Madhurya Chandel, Vaibhavkumar N Mehta, Tae Jung Park
In this work, we describe the role of ligand chemistry on the surfaces of silver nanoparticles (Ag NPs) for tuning their analytical applications. The citrate and melamine (MA) molecules were used as ligands for the surface modification of Ag NPs. The addition of Cr3+ ion in citrate-Ag NPs (Cit-Ag NPs) and of Hg2+ ion in melamine-Ag NPs (MA-Ag NPs) cause Ag NPs aggregation, and are accompanied by a color change and a red-shift. The resulting distinctly visual readouts are favorable for colorimetric detection of Cr3+ and Hg2+ ions...
January 26, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29411062/aerogel-from-chemo-enzymatically-oxidized-fenugreek-gum-an-innovative-delivery-system-of-isothiazolinones-biocides
#16
Tiziana Silvetti, Luca Merlini, Milena Brasca, Yves M Galante
Aerogels of chemo-enzymatically oxidized, lyophilized fenugreek gum (EOLFG) were evaluated as "delivery system" (DS) of the microbiocide mix 5-chloro-2-methyl-4-isothiazolin-3-one (CIT) and 2-methyl-4-isothiazolin-3-one (MIT). These biocides have a broad activity spectrum and a low MIC (minimal inhibitory concentration) in the ppm range. They are approved under the EU Biocidal Product Directive for various applications, including cosmetics, are classified as skin sensitizers, and are under increasing scrutiny to limit or eliminate their use...
February 6, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29406901/scan-without-evidence-of-dopaminergic-deficit-swedd-in-degenerative-parkinsonism-and-dementia-with-lewy-bodies-a-prospective-study
#17
Nicolas Nicastro, Pierre R Burkhard, Valentina Garibotto
BACKGROUND: 123I-FP-CIT SPECT imaging is a reliable method to assess presynaptic dopaminergic pathways in degenerative parkinsonisms and dementia with Lewy bodies (DLB). METHODS: We aimed at examining sensitivity of combined visual and semi-quantitative 123I-FP-CIT SPECT analyses in a prospective cohort of subjects with DLB and degenerative parkinsonisms - Parkinson's disease (PD), multiple system atrophy (MSA), corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP) to determine prevalence and clinical significance of scans without evidence of dopaminergic deficit (SWEDD)...
February 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29394491/impact-of-l-citrulline-supplementation-on-oxygen-uptake-kinetics-during-walking
#18
John Ashley, Youngdeok Kim, Joaquin U Gonzales
Supplementation with L-citrulline (Cit) has been shown to improve muscle oxygenation and oxygen uptake (VO2) kinetics during moderate-to-high intensity cycling in young men. The aim of this study was to test the hypothesis whether Cit would improve VO2 kinetics during walking in older and young adults. In a randomized, double-blind study, 26 (15 women, 11 men) adults between the ages of 20-35y (n = 15) and 64-86y (n = 11) completed 7 day periods of taking placebo and L-citrulline (6 g/day) in a crossover manner...
February 2, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29389767/outcomes-of-donation-after-cardiac-death-liver-grafts-from-donors-%C3%A2-50-years-of-age-a-multi-center-analysis
#19
Kristopher P Croome, Amit K Mathur, David D Lee, Adyr A Moss, Charles B Rosen, Julie K Heimbach, C Burcin Taner
INTRODUCTION: As the population in the United States continues to age, an increase in the number of potential DCD donors with advanced chronological age can be expected. The aim of this study was to analyze a multi-institutional experience in liver transplantation using DCD donor age ≥50 years. METHODS: All DCD LT performed at Mayo Clinic Florida, Mayo Clinic Rochester and Mayo Clinic Arizona from 2002-2016 were included. Recipients of DCD LT were divided into 2 groups: those with donor age ≥50 years(N=155) and those with donor age <50 years(N=316)...
January 31, 2018: Transplantation
https://www.readbyqxmd.com/read/29385621/outgroup-emotion-processing-in-the-vacc-is-modulated-by-childhood-trauma-and-cacna1c-risk-variant
#20
Johannes T Krautheim, Benjamin Straube, Udo Dannlowski, Martin Pyka, Henriette Schneider-Hassloff, Rebecca Drexler, Axel Krug, Jens Sommer, Marcella Rietschel, Stephanie H Witt, Tilo Kircher
A high frequency of outgroup contact - as experienced by urban dwellers and migrants - possibly increases schizophrenia risk. This risk might be further amplified by genetic and environmental risk factors, such as the A-allele of rs1006737 within the Calcium Voltage-Gated Channel Subunit Alpha1 C (CACNA1C) gene and Childhood Interpersonal Trauma (CIT). Both have been related to ventral anterior cingulate cortex (vACC) functioning. We investigated vACC functioning, during ingroup and outgroup emotion perception in relation to rs1006737 and CIT...
January 29, 2018: Social Cognitive and Affective Neuroscience
keyword
keyword
95491
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"