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https://www.readbyqxmd.com/read/29222277/how-should-we-sequence-and-combine-novel-therapies-in-cll
#1
REVIEW
Matthew S Davids
With the recent approval of several effective and well-tolerated novel agents (NAs), including ibrutinib, idelalisib, venetoclax, and obinutuzumab, patients with chronic lymphocytic leukemia (CLL) have more therapeutic options than ever before. The availability of these agents is both an important advance for patients but also a challenge for practicing hematologist/oncologists to learn how best to sequence NAs, both with respect to chemoimmunotherapy (CIT) and to other NAs. The sequencing of NAs in clinical practice should be guided both by an individual patient's prognostic markers, such as FISH and immunoglobulin heavy chain variable region (IGHV)-mutation status, as well as the patient's medical comorbidities and goals of care...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29220692/plag-alleviates-chemotherapy-induced-thrombocytopenia-via-promotion-of-megakaryocyte-erythrocyte-progenitor-differentiation-in-mice
#2
Ha-Reum Lee, Nina Yoo, Jinseon Jeong, Ki-Young Sohn, Sun Young Yoon, Jae Wha Kim
Previously, PLAG (1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol, acetylated diglyceride) was reported to have an effect on the proliferation of hematopoietic stem cells (HSCs) or to contribute to the prevention of chemotherapy-induced neutropenia. In this study, we examined the role of PLAG in the differentiation of bone marrow cells from HSCs into progenitor cells in mice. After 15days, the lineage-negative cells, especially megakaryocyte/erythrocyte progenitors (MEP), were significantly increased in mice that received daily PLAG administration compared to those in the untreated mice...
October 10, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29215405/123i-fp-cit-spect-accurately-distinguishes-parkinsonian-from-cerebellar-variant-of-multiple-system-atrophy
#3
Nicolas Nicastro, Valentina Garibotto, Pierre R Burkhard
PURPOSE: Dopamine transporter SPECT imaging is a valuable tool to estimate the integrity of presynaptic dopaminergic pathways in degenerative parkinsonisms. Evidence about SPECT differential pattern between parkinsonian and cerebellar forms of multiple system atrophy (MSA-P and MSA-C) is lacking. We aimed at assessing whether MSA-P and MSA-C variants have a distinct semiquantitative I-FP-CIT SPECT pattern. METHODS: We studied a unicentric 13-year (2003-2016) retrospective cohort of subjects with possible or probable MSA and scanned with the same acquisition and reconstruction SPECT protocol...
December 5, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29214016/genotypic-characterization-of-gentamicin-and-cephalosporin-resistant-escherichia-coli-isolates-from-blood-cultures-in-a-norwegian-university-hospital-2011-2015
#4
Øyvind Andreas Fladberg, Silje Bakken Jørgensen, Hege Vangstein Aamot
Background: Cephalosporin resistance in clinical E. coli isolates is increasing internationally. The increase has been caused by virulent and often multidrug-resistant clones, especially the extended spectrum β-lactamase (ESBL) producing E. coli clone O25b-ST131. Methods: In Norway, recommended empirical treatment of sepsis consists of gentamicin and penicillin combined, or a broad-spectrum cephalosporin. To investigate if increased gentamicin and cephalosporins resistance rates in our hospital could be caused by specific clones, we conducted a retrospective study on E...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29212608/clinical-islet-transplantation-for-type-1-diabetes-in-canada-referral-patterns-and-eligibility-assessment
#5
Ying Ling, Aashna Gill, Richard Oram, A M James Shapiro, Peter Senior
OBJECTIVES: Careful selection for clinical islet transplantation (CIT) is required because of limited organ supply and the risks for lifelong immunosuppression. However, the indications for this novel treatment may not be widely known, and selection criteria continue to evolve. We sought to describe the pattern of referrals to our centre and the most common factors determining eligibility for CIT. METHODS: We performed a retrospective chart review of all applications for CIT received at the University of Alberta between May 2009 and April 2012...
December 4, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29208868/detection-of-plasmid-mediated-ampc-%C3%AE-lactamases-among-gram-negative-uropathogens-at-a-tertiary-care-hospital-dhaka-city
#6
N Begum, S M Shamsuzzaman, S Afroz, A K Azad
Plasmid-mediated AmpC β-lactamase (PMABL) resistance among gram negative bacilli is an emerging problem worldwide. They likely originate from chromosomal AmpC of certain Gram-negative bacterial species and subsequently are mobilized to transmissible plasmids. There are reports of unfavorable clinical outcomes in patients infected with these organisms and treated with broad-spectrumcephalosporins. The present cross sectional study was designed to detect PMABL genes among gram negative uropathogens in a tertiary care hospital, Dhaka city, Bangladesh from January 2014 to December 2014...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29202867/testing-the-4rs-and-2ss-multiple-family-group-intervention-study-protocol-for-a-randomized-controlled-trial
#7
Mary Acri, Emily Hamovitch, Maria Mini, Elene Garay, Claire Connolly, Mary McKay
BACKGROUND: Oppositional defiant disorder (ODD) is a major mental health concern and highly prevalent among children living in poverty-impacted communities. Despite that treatments for ODD are among the most effective, few children living in poverty receive these services due to substantial barriers to access, as well as difficulties in the uptake and sustained adoption of evidence-based practices (EBPs) in community settings. The purpose of this study is to examine implementation processes that impact uptake of an evidence-based practice for childhood ODD, and the impact of a Clinic Implementation Team (CIT)-driven structured adaptation to enhance its fit within the public mental health clinic setting...
December 4, 2017: Trials
https://www.readbyqxmd.com/read/29200226/green-synthesis-of-a-new-layered-aluminium-citraconate-crystal-structures-intercalation-behaviour-towards-h2o-and-in-situ-pxrd-studies-of-its-crystallisation
#8
Niclas Heidenreich, Alexandra Lieb, Norbert Stock, Helge Reinsch
A new Al-based layered MOF [Al2(OH)4(O2C-C3H4-CO2)]·nH2O denoted as CAU-15-Cit was synthesised under mild aqueous conditions. It exhibits a layered structure incorporating infinite chains of edge-sharing AlO6 polyhedra being interconnected by citraconate anions to arrange into layers, which are stacked in an AAA fashion (citraconic acid = methylmaleic acid = H2Cit, HO2C-C3H4-CO2H). The crystal structures of the hydrated and dehydrated MOF were determined ab initio from powder X-ray diffraction (PXRD) data...
December 4, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29199345/-clinical-application-of-individualized-three-dimensional-printing-implant-template-in-multi-tooth-dental-implantation
#9
Lie Wang, Zhi-Yuan Chen, Rong Liu, Hao Zeng
PURPOSE: To study the value and satisfaction of three-dimensional printing implant template and conventional implant template in multi-tooth dental implantation. METHODS: Thirty cases (83 teeth) with missing teeth needing to be implanted were randomly divided into conventional implant template group (CIT group, 15 cases, 42 teeth) and 3D printing implant template group (TDPIT group, 15 cases, 41 teeth). Patients in CIT group were operated by using conventional implant template, while patients in TDPIT group were operated by using three-dimensional printing implant template...
August 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/29195972/impact-of-phenylalanine-and-urea-applications-to-tempranillo-and-monastrell-vineyards-on-grape-amino-acid-content-during-two-consecutive-vintages
#10
Teresa Garde-Cerdán, Gastón Gutiérrez-Gamboa, Javier Portu, José Ignacio Fernández-Fernández, Rocío Gil-Muñoz
Nitrogen plays a key role in the fermentation and secondary metabolites formation. The aim was to study the influence of vine nitrogen applications on grape amino acid composition. Nitrogen sources applied to Tempranillo and Monastrell grapevines were phenylalanine and urea, during two seasons. Results showed that the application of these compounds had little effect on grape amino acid composition, regardless of variety and vintage. This could be due to the fact that vineyards did not present nitrogenous requirements...
December 2017: Food Research International
https://www.readbyqxmd.com/read/29189505/development-of-a-comprehensive-and-interactive-tool-to-inform-state-violence-and-injury-prevention-plans
#11
Lauren Wilson, Angela J Deokar, Araya Zaesim, Karen Thomas, Marcie-Jo Kresnow-Sedacca
CONTEXT: The Center of Disease Control and Prevention's Core State Violence and Injury Prevention Program (Core SVIPP) provides an opportunity for states to engage with their partners to implement, evaluate, and disseminate strategies that lead to the reduction and prevention of injury and violence. Core SVIPP requires awardees to develop or update their state injury and violence plans. Currently, literature informing state planning efforts is limited, especially regarding materials related to injury and violence...
January 2018: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/29188397/comparison-of-machine-learning-and-semi-quantification-algorithms-for-i123-fp-cit-classification-the-beginning-of-the-end-for-semi-quantification
#12
Jonathan Christopher Taylor, John Wesley Fenner
BACKGROUND: Semi-quantification methods are well established in the clinic for assisted reporting of (I123) Ioflupane images. Arguably, these are limited diagnostic tools. Recent research has demonstrated the potential for improved classification performance offered by machine learning algorithms. A direct comparison between methods is required to establish whether a move towards widespread clinical adoption of machine learning algorithms is justified. This study compared three machine learning algorithms with that of a range of semi-quantification methods, using the Parkinson's Progression Markers Initiative (PPMI) research database and a locally derived clinical database for validation...
November 29, 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/29185861/of-rings-and-spines-the-multiple-facets-of-citron-proteins-in-neural-development
#13
Federico T Bianchi, Marta Gai, Gaia E Berto, Ferdinando Di Cunto
The Citron protein was originally identified for its capability to specifically bind the active form of RhoA small GTPase, leading to the simplistic hypothesis that it may work as a RhoA downstream effector in actin remodeling. More than two decades later, a much more complex picture has emerged. In particular, it has become clear that in animals, and especially in mammals, the functions of the Citron gene (CIT) are intimately linked to many aspects of central nervous system (CNS) development and function, although the gene is broadly expressed...
November 29, 2017: Small GTPases
https://www.readbyqxmd.com/read/29181584/testing-a-potential-alternative-to-traditional-identification-procedures-reaction-time-based-concealed-information-test-does-not-work-for-lineups-with-cooperative-witnesses
#14
Melanie Sauerland, Andrea C F Wolfs, Samantha Crans, Bruno Verschuere
Direct eyewitness identification is widely used, but prone to error. We tested the validity of indirect eyewitness identification decisions using the reaction time-based concealed information test (CIT) for assessing cooperative eyewitnesses' face memory as an alternative to traditional lineup procedures. In a series of five experiments, a total of 401 mock eyewitnesses watched one of 11 different stimulus events that depicted a breach of law. Eyewitness identifications in the CIT were derived from longer reaction times as compared to well-matched foil faces not encountered before...
November 27, 2017: Psychological Research
https://www.readbyqxmd.com/read/29178132/thrombopoietin-receptor-agonists-for-prevention-and-treatment-of-chemotherapy-induced-thrombocytopenia-in-patients-with-solid-tumours
#15
REVIEW
Xia Zhang, Yunhai Chuai, Wei Nie, Aiming Wang, Guanghai Dai
BACKGROUND: Chemotherapy-induced thrombocytopenia (CIT) is defined as a peripheral platelet count less than 100×109/L, with or without bleeding in cancer patients receiving myelosuppressive chemotherapy. CIT is a significant medical problem during chemotherapy, and it carries the risk of sub-optimal overall survival and bleeding. Alternative interventions to platelet transfusion are limited. Different stages of preclinical and clinical studies have examined the thrombopoietin receptor agonists (TPO-RAs) for CIT in patients with solid tumours...
November 27, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29176566/nanoscale-investigation-of-enhanced-electron-field-emission-for-silver-ion-implanted-post-annealed-ultrananocrystalline-diamond-films
#16
Kalpataru Panda, Jeong Jin Hyeok, Jeong Young Park, Kamatchi Jothiramalingam Sankaran, Sundaravel Balakrishnan, I-Nan Lin
Silver (Ag) ions are implanted in ultrananocrystalline diamond (UNCD) films to enhance the electron field emission (EFE) properties, resulting in low turn-on field of 8.5 V/μm with high EFE current density of 6.2 mA/cm2 (at an applied field of 20.5 V/μm). Detailed nanoscale investigation by atomic force microscopy based peak force-controlled tunneling atomic force microscopy (PF-TUNA) and ultra-high vacuum scanning tunneling microscopy (STM) based current imaging tunneling spectroscopy (CITS) reveal that the UNCD grain boundaries are the preferred electron emission sites...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29172590/the-mediating-effect-of-family-cohesion-in-reducing-patient-symptoms-and-family-distress-in-a-culturally-informed-family-therapy-for-schizophrenia-a-parallel-process-latent-growth-model
#17
Caitlin A Brown, Amy Weisman de Mamani
OBJECTIVE: Although both patients with schizophrenia and their caregivers report elevated levels of depression, anxiety, and stress (DASS), affective symptoms in patients and family members seldom constitute a primary treatment focus. The present study tested whether a culturally informed family therapy for schizophrenia (CIT-S) outperformed standard family psychoeducation (PSY-ED) not only in decreasing patient schizophrenia symptoms, but also in decreasing individual DASS. Because CIT-S fostered family cohesion throughout treatment, we predicted that increases in family cohesion would mediate treatment effects...
November 27, 2017: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/29165871/shipping-living-donor-kidneys-and-transplant-recipient-outcomes
#18
Eric Treat, Eric K H Chow, John D Peipert, Amy Waterman, Lorna Kwan, Allan B Massie, Alvin G Thomas, Mary Grace Bowring, David Leeser, Stuart Flechner, Marc L Melcher, Sandip Kapur, Dorry L Segev, Jeffrey Veale
Kidney paired donation (KPD) is an important tool to facilitate living donor kidney transplantation (LDKT). Concerns remain over prolonged cold ischemia times (CIT) associated with shipping kidneys long distances through KPD. We examined the association between CIT and delayed graft function (DGF), allograft survival, and patient survival for 1,267 shipped and 205 non-shipped/internal KPD LDKTs facilitated by the National Kidney Registry in the United States from 2008-2015, compared to 4,800 unrelated, non-shipped, non-KPD LDKTs...
November 22, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29164972/molecular-subtyping-of-breast-cancer-improves-identification-of-both-high-and-low-risk-patients
#19
Maria Rossing, Olga Østrup, Wiktor W Majewski, Savvas Kinalis, Maj-Britt Jensen, Ann Knoop, Niels Kroman, Maj-Lis Talman, Thomas V O Hansen, Bent Ejlertsen, Finn C Nielsen
BACKGROUND: Transcriptome analysis enables classification of breast tumors into molecular subtypes that correlate with prognosis and effect of therapy. We evaluated the clinical benefits of molecular subtyping compared to our current diagnostic practice. MATERIALS AND METHODS: Molecular subtyping was performed on a consecutive and unselected series of 524 tumors from women with primary breast cancer (n = 508). Tumors were classified by the 256 gene expression signature (CIT) and compared to conventional immunohistochemistry (IHC) procedures...
November 22, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29164968/characterization-of-basal-like-subtype-in-a-danish-consecutive-primary-breast-cancer-cohort
#20
Savvas Kinalis, Finn Cilius Nielsen, Maj-Lis Talman, Bent Ejlertsen, Maria Rossing
BACKGROUND: Transcriptome analysis enables classification of breast tumors into molecular subtypes. BRCA1/2 predisposed patients are more likely to suffer from a basal-like subtype and this group of patients displays a more distinct phenotype and genotype. Hence, in-depth characterization of this separate entity is needed. MATERIAL AND METHODS: Molecular subtyping was performed on a consecutive and unselected series of 1560 tumors from patients with primary breast cancer...
November 22, 2017: Acta Oncologica
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