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Akira Toriihara, Hiromitsu Daisaki, Akihiro Yamaguchi, Makoto Kobayashi, Shogo Furukawa, Katsuya Yoshida, Jun Isogai, Ukihide Tateishi
PURPOSE: To evaluate potential of a semiquantitative method using standardized uptake value (SUV) in 123 I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane (123 I-FP-CIT) single photon emission computed tomography/computed tomography (SPECT/CT) compared with specific binding ratio (SBR). MATERIALS AND METHODS: First, we performed a phantom study to validate the accuracy of measuring SUV. 52 patients (25 male, 27 female; mean age of 75.1-year-old; 40 and 12 patients with neurodegenerative diseases with or without presynaptic dopaminergic deficits, respectively) were enrolled in a retrospective study...
June 14, 2018: Clinical Imaging
Jian Zheng, Hong Zhang, Chun Wang
BACKGROUND: Intradiploic epidermoid cyst (IEC) concurrent with chronic epidural hematoma (CEDH) has never been reported in the literature. We report a unique case of IEC concurrent with anatomically close associated CEDH. CASE DESCRIPTION: A 54-year-old man presented with one week history of headache, confusion and drowsiness. Computed tomography (CT) exposed large extraaxial mixed density lesions with bone destruction and substantial mass effect in the left fronto-temporal region...
June 14, 2018: World Neurosurgery
Vladimir Ostry, Frantisek Malir, Martina Cumova, Veronika Kyrova, Jakub Toman, Yann Grosse, Marketa Pospichalova, Jiri Ruprich
Twenty three strains of Penicillium expansum, as a predominant species, were isolated from 23 (92%) out of 25 grape samples of 17 different grape varieties. The results of the identification of P. expansum strains were confirmed by a PCR method. Most of the isolates of P. expansum (21/23, 91%), when tested for toxigenicity, were bi-toxigenic: they produced citrinin (CIT) and particularly high amounts of patulin (PAT). A validated UPLC-MS/MS method for the determination of PAT and CIT was applied. The limits of quantification (LOQ) for PAT and CIT in grape must and toxigenicity testing samples were 100 and 2 ng/g, respectively...
June 13, 2018: Food and Chemical Toxicology
Linda M Geven, Gershon Ben-Shakhar, Merel Kindt, Bruno Verschuere
From a cognitive perspective, lying can be regarded as a complex cognitive process requiring the interplay of several executive functions. Meta-analytic research on 114 studies encompassing 3,307 participants (Suchotzki, Verschuere, Van Bockstaele, Ben-Shakhar, & Crombez, ) suggests that computerized paradigms can reliably assess the cognitive burden of lying, with large reaction time differences between lying and truth telling. These studies, however, lack a key ingredient of real-life deception, namely self-initiated behavior...
June 15, 2018: Topics in Cognitive Science
Álvaro Roy, José Antonio Infantes-Lorenzo, Juan Carlos Blázquez, Ángel Venteo, Francisco José Mayoral, Mercedes Domínguez, Inmaculada Moreno, Beatriz Romero, Lucía de Juan, Anna Grau, Lucas Domínguez, Javier Bezos
Vaccination against paratuberculosis (PTB) in goats is a cost-effective control strategy, and is also effective as regards preventing the onset of clinical cases. However, it causes interference in the diagnostic tests used in the control of tuberculosis (TB). A group of 99 goats from a herd with no history of TB or PTB infection was vaccinated against PTB at seven months of age. They then underwent consecutive intradermal tests [single (SIT) and comparative (CIT) intradermal tuberculin tests), interferon-gamma release assays (IGRA) and two serological tests (p22_CE and DR-ELISA) every three months, until the interference disappeared...
August 1, 2018: Preventive Veterinary Medicine
Philine von Tippelskirch, Greta Gölz, Michaela Projahn, Katrin Daehre, Anika Friese, Uwe Roesler, Thomas Alter, Stefanie Orquera
Food producing animals are considered a reservoir for Extended-spectrum beta-lactamase (ESBL) and AmpC beta-lactamase (AmpC) producing Enterobacteriaceae. Therefore, meat is discussed to be a potential source for the transmission of these resistant bacteria to humans. There is only limited information about the quantitative load of ESBL-/AmpC-producing Enterobacteriaceae in different sample matrices during slaughter and their distribution in the slaughterhouse environment. Therefore, the aim of this study was to determine the prevalence as well as quantitative load of ESBL-/AmpC-producing Enterobacteriaceae in caecum, skin and filet samples of different broiler chicken flocks during slaughter in Germany...
May 25, 2018: International Journal of Food Microbiology
Georg Gdynia, Tadeusz Robak, Jürgen Kopitz, Anette Heller, Svetlana Grekova, Katarina Duglova, Gloria Laukemper, Monika Heinzel-Gutenbrunner, Cornelius Gutenbrunner, Wilfried Roth, Anthony D Ho, Peter Schirmacher, Michael Schmitt, Peter Dreger, Leopold Sellner
A higher capacity to grow under hypoxic conditions can lead to a more aggressive behavior of tumor cells. Determining tumor activity under hypoxia may identify chronic lymphocytic leukemia (CLL) with aggressive clinical course and predict response to chemo-immunotherapy (CIT). A metabolic score was generated by determining pyruvate kinase and lactate dehydrogenase, key enzymes of glycolysis, ex vivo in primary CLL samples under normoxic and hypoxic conditions. This score was further correlated with clinical endpoints and response to CIT in 96 CLL patients...
June 5, 2018: EBioMedicine
K Dziewanowski, M Myślak, R Drozd, E Krzystolik, A Krzystolik, M Ostrowski, M Droździk, K Tejchman, K Kozdroń, J Sieńko
BACKGROUND: Kidney transplantation is a routine procedure in the treatment of patients with kidney failure and requires collaboration of experts from different disciplines. Improvements in the procedure result from numerous factors. METHODS: The analyzed group consisted of 150 patients divided into 2 equal subgroups: long-term (>15 years) and short-term (<6 years) graft survival. The following factors were taken into consideration: graft survival time, HLA mismatches, recipient sex, sex compatibility, panel reactive antibodies (PRA), cold ischemia time (CIT), and cause of kidney insufficiency...
June 2018: Transplantation Proceedings
Wilfredo D Mansilla, Kayla E Silva, Cuilan Zhu, Charles M Nyachoti, John K Htoo, John P Cant, Cornelis F M de Lange
Background: Dietary ammonia is rapidly absorbed but poorly used for urea synthesis in pigs fed low-crude-protein (low-CP) diets deficient in dispensable amino acid (DAA)-nitrogen. Objective: We explored the effect of dietary ammonia on net amino acid (AA) balances in portal-drained viscera (PDV) and livers of pigs fed a diet deficient in DAA-nitrogen. Methods: Eight barrows with an initial body weight (BW) of 26.5 ± 1.4 kg (mean + SD) were surgically fitted with 4 catheters each (portal, hepatic, and mesenteric veins and carotid artery)...
June 7, 2018: Journal of Nutrition
Haruka Takeshige, Sachiko Nakayama, Kenya Nishioka, Yuanzhe Li, Yumiko Motoi, Nobutaka Hattori
We herein report two patients harboring the mutation N279K in MAPT, who showed parkinsonism with a disease duration within three years from the onset, evaluated by dopamine transporter (DAT) [123 I]N-ω-fluoroprophyl-2β-carbomethoxy-3β-(4-iodophenyl) tropane (123 I-FP-CIT) single-photon emission computed tomography (SPECT). We performed a quantification analysis, comparing five age- and severity-matched PD patients and six normal controls. The patients with the N279K mutation showed a more marked reduction in their DAT densities, especially in the caudate nucleus and anterior putamen, than the others...
June 6, 2018: Internal Medicine
Tolga Turan, Deepti Kannan, Maulik Patel, J Matthew Barnes, Sonia G Tanlimco, Rongze Lu, Kyle Halliwill, Sarah Kongpachith, Douglas E Kline, Wouter Hendrickx, Alessandra Cesano, Lisa H Butterfield, Howard L Kaufman, Thomas J Hudson, Davide Bedognetti, Francesco Marincola, Josue Samayoa
Anti-cancer immunotherapy is encountering its own checkpoint. Responses are dramatic and long lasting but occur in a subset of tumors and are largely dependent upon the pre-existing immune contexture of individual cancers. Available data suggest that three landscapes best define the cancer microenvironment: immune-active, immune-deserted and immune-excluded. This trichotomy is observable across most solid tumors (although the frequency of each landscape varies depending on tumor tissue of origin) and is associated with cancer prognosis and response to checkpoint inhibitor therapy (CIT)...
June 5, 2018: Journal for Immunotherapy of Cancer
Oscar K Serrano, David M Vock, Srinath Chinnakotla, Ty B Dunn, Raja Kandaswamy, Timothy L Pruett, Roger Feldman, Arthur J Matas, Erik B Finger
BACKGROUND: Recent changes in policies guiding allocation of transplant kidneys are predicted to increase sharing between distant geographic regions. The potential exists for an increase in cold ischemia time (CIT) with resulting increases in delayed graft function (DGF) and transplant-related costs (TRC). We sought to explore the impact of CIT on metrics that may influence TRC. METHODS: Between 2006 and 2014, 81,945 adult solitary deceased donor kidney transplants (KT) were performed in the United States; 477 (0...
May 31, 2018: Transplantation
Yutaka Toyomasu, Yusuke Demizu, Yoshiro Matsuo, Nor Shazrina Sulaiman, Masayuki Mima, Fumiko Nagano, Kazuki Terashima, Sunao Tokumaru, Tomokatsu Hayakawa, Takashi Daimon, Nobukazu Fuwa, Hajime Sakuma, Yoshihito Nomoto, Tomoaki Okimoto
PURPOSE: This retrospective study aimed to determine the clinical outcomes following particle monotherapy (ie, proton therapy [PT] or carbon ion therapy [CIT]) in patients with sinonasal squamous cell carcinoma at a single institution. METHODS AND MATERIALS: Between August 2001 and March 2012, 59 patients were treated with definitive PT or CIT; none underwent chemotherapy or surgery. Of the patients, 22 (37%) had unresectable disease. PT was used in 38 patients (64%); CIT, 21 patients (36%)...
April 22, 2018: International Journal of Radiation Oncology, Biology, Physics
Kwang Jae Yu, Byung Joo Lee, Jin Han, Donghwi Park
RATIONALE: Treating the patients with hand tremors is clinically difficult, because a wide range of disorders can result in hand tremors. Therefore, when treatment for hand tremors begins, various pharmacological options have to be considered. In clinical practice, a practical approach is to initially check hand tremor patients for signs of Parkinson's disease (PD), because patients with PD can benefit from dopamine treatment. However, only part of patients with PD tends to show a meaningful improvement in hand tremors for dopamine treatment...
June 2018: Medicine (Baltimore)
Eiji Matsusue, Yoshio Fujihara, Kenichiro Tanaka, Yuki Aozasa, Manabu Shimoda, Hiroyuki Nakayasu, Kazuhiko Nakamura, Toshihide Ogawa
Background Neuromelanin magnetic resonance imaging (NmMRI) and 123 I-FP-CIT dopamine transporter single photon emission computed tomography (DAT-SPECT) provide specific information that distinguishes Parkinson's disease (PD) from non-degenerative parkinsonian syndrome (NDPS). Purpose To determine whether a multiparametric scoring system (MSS) could improve accuracy compared to each parameter of DAT-SPECT and NmMRI in differentiating PD from NDPS. Material and Methods A total of 49 patients, including 14 with NDPS, 30 with PD, and five with atypical parkinsonian disorder (APD) underwent both NmMRI and DAT-SPECT and were evaluated...
January 1, 2018: Acta Radiologica
Haohan Yang, Guanghua Lu, Zhenhua Yan, Jianchao Liu, Huike Dong
The influence of suspended sediment (SPS) characteristics on the bioavailability of the antidepressant citalopram (CIT) was investigated in the cladoceran Daphnia magna. The bioaccumulation, swimming behaviours, psychological indices, and oxidative stress were examined. The CIT bioaccumulation were altered in the presence of SPS, such that the body burden of CIT decreased as the concentration of SPS increased and as the organic carbon content of SPS (foc ) increased; moreover, the body burden of CIT increased as SPS particle size increased...
May 24, 2018: Chemosphere
Ruth Djaldetti, Amihai Rigbi, Lior Greenbaum, Johnathan Reiner, Mordechai Lorberboym
BACKGROUND: The role of nuclear imaging in predicting Parkinson's disease (PD) progression is unclear. This study investigated whether the degree of reduced striatal dopamine transporter binding at diagnosis of PD predicts later motor complications and time to disease progression. METHODS: We retrospectively studied 41 patients with early PD who underwent 123 I-FP-CIT SPECT and were followed thereafter with a mean disease duration of 9.51 ± 3.18 years. The association of quantitatively analyzed 123 I-FP-CIT binding in striatal subregions with the development of motor fluctuations, dyskinesias, freezing of gait (FOG) and falls as well as the time to Hoehn and Yahr (H&Y) stage 3 was evaluated...
July 15, 2018: Journal of the Neurological Sciences
Hiroshi Komatsu, Masaaki Kato, Teiko Kinpara, Takashi Ono, Yoshihisa Kakuto
BACKGROUND: Multiple system atrophy (MSA) is an adult-onset, rare, and progressive neurodegenerative disorder characterized by a varying combination of autonomic failure, cerebellar ataxia, and parkinsonism. MSA is categorized as MSA-P with predominant parkinsonism, and as MSA-C with predominant cerebellar features. The prevalence of MSA has been reported to be between 1.86 and 4.9 cases per 100,000 individuals. In contrast, approximately 1% of the population is affected by schizophrenia during their lifetime; therefore, MSA-P comorbidity is very rare in schizophrenic patients...
May 21, 2018: BMC Psychiatry
Jesús Oteo, Aida Mencía, Verónica Bautista, Natalia Pastor, Noelia Lara, Fernando González-González, Francisco Javier García-Peña, José Campos
Antibiotic resistance is a global threat of complex and changeable epidemiology. The role of wild birds in the dissemination of antibacterial resistance might be underestimated. We studied the cloacal colonization by cefotaxime-resistant Enterobacteriaceae in 668 wild birds in Spain. Eighty-eight wild birds (13.2%) of 28 species carried cefotaxime-resistant isolates; 58 of them (8.7%) carried extended-spectrum β-lactamases (ESBLs) and 15 (2.5%) plasmid-mediated AmpCs of the blaCIT family. The 58 ESBLs belonged to the CTX-M-1 group (63...
May 21, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
Kristina Suchotzki, Matthias Gamer
The Concealed Information Test (CIT) is a well-validated means to detect whether someone possesses certain (e.g., crime-relevant) information. The current study investigated whether alcohol intoxication during CIT administration influences reaction time (RT) CIT-effects. Two opposing predictions can be made. First, by decreasing attention to critical information, alcohol intoxication could diminish CIT-effects. Second, by hampering the inhibition of truthful responses, alcohol intoxication could increase CIT-effects...
May 18, 2018: Scientific Reports
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