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Recurrent otitis

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https://www.readbyqxmd.com/read/28541783/cyclosporine-causes-no-hearing-defect-in-paediatric-patients-with-nephrotic-syndrome
#1
Belde Kasap-Demir, Derya Özmen, Günay Kırkım, Ersoy Doğan, Alper Soylu, Bülent Şerbetçioğlu, Salih Kavukçu
OBJECTIVE: We aimed to evaluate the ototoxicity of cyclosporine A (CsA) in children with nephrotic syndrome (NS). DESIGN: Data of paediatric patients with NS followed in paediatric nephrology department were evaluated retrospectively, and hearing functions were evaluated by pure tone audiometry (PTA) and transient evoked otoacoustic emissions (TEOAEs). Age, gender, type of NS, duration and cumulative doses of immunosuppressives were noted. STUDY SAMPLE: The patients who had received CsA (n: 16) and immunosuppressives other than CsA (n: 13) for at least 6 months formed two patient groups and healthy cases formed a control group (n: 20)...
May 25, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28540514/the-effectiveness-of-myringotomy-and-ventilation-tube-insertion-versus-observation-in-post-radiation-otitis-media-with-effusion
#2
Paninee Charusripan, Likhit Khattiyawittayakun
To compare the effectiveness of myringotomy and ventilation tube insertion versus observation in post-radiation otitis media with effusion (OME) in nasopharyngeal carcinoma (NPC). NPC patients who finished radiotherapy and had persistent OME were randomized to myringotomy and ventilation tube insertion and observation groups. The resolution rate of OME and hearing outcomes were evaluated. Forty three patients (23 in control group and 20 in intervention group) were analyzed. One patient in the control group obtained a resolution of OME...
May 24, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28535362/tympanostomy-tube-placement-vs-medical-management-for-recurrent-acute-otitis-media-in-tricare-insured-children
#3
Nikhila Raol, Meesha Sharma, Emily F Boss, Wei Jiang, John W Scott, Peter Learn, Joel S Weissman
Objective To compare number of infections and health care utilization in children insured by TRICARE with recurrent acute otitis media (RAOM) managed surgically with tympanostomy tube (TT) placement compared with those managed medically. Study Design Retrospective matched cohort study. Setting TRICARE claims database from 2006 to 2010. Subjects and Methods We matched TRICARE beneficiaries ≤5 years of age diagnosed with RAOM who underwent TT placement with those managed medically using 1:1 coarsened-exact matching on age, sex, race, sponsor rank, and region...
May 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28491450/contribution-of-oral-triamcinolone-to-treating-proliferative-and-necrotising-otitis-externa-in-a-14-year-old-persian-cat
#4
Yutaka Momota, Junya Yasuda, Nobuaki Arai, Masami Yamamoto, Hisashi Yoshimura, Mitsutaka Ikezawa, Shuji Suzuki, Kimimasa Takahashi, Toshinori Sako
CASE SUMMARY: A 14-year-old female spayed cat was referred for recurrent otitis externa and unusual proliferative lesions in both ear canals. The affected pinnae and external ear canals were covered with large reddish-to-dark-brown verrucous and necrotic tissue. Friable material and exudates occluded both ear canals. Proliferative lesions developed in both ears 2-3 weeks before referral. The histopathological diagnosis from two biopsies obtained from the friable materials with endoscopic biopsy forceps was proliferative and necrotising otitis externa (PNOE)...
January 2017: JFMS Open Rep
https://www.readbyqxmd.com/read/28466356/recurrent-otorrhea-in-chronic-suppurative-otitis-media-is-biofilm-the-missing-link
#5
Ramon Gordon Jensen, Helle Krogh Johansen, Thomas Bjarnsholt, Steffen Robert Eickhardt-Sørensen, Preben Homøe
Dispersal of bacteria from a biofilm in the middle ear, serving as a bacterial reservoir, could explain the recurrent and chronic nature of chronic suppurative otitis media (CSOM). The objective of this study is to investigate if the same strains of bacteria could be detected in repeated episodes of otorrhea in CSOM. In a prospective case series at a primary healthcare clinic in Nuuk, Greenland, patients with more than 14 days of otorrhea were included consecutively. Samples for culturing and biofilm analysis were taken at enrollment and at any subsequent episode with otorrhea...
May 2, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28446389/infectious-and-non-infectious-pulmonary-complications-in-primary-immunodeficiencies
#6
R Yazdani, H Abolhassani, M Asgardoon, M Shaghaghi, M Modaresi, G Azizi, A Aghamohammadi
Primary immunodeficiency disorders (PIDs) have been described as diseases caused by one or more defects of the immune system. These patients are more likely to experience recurrent and/or severe infections and have a tendency to develop a wide range of complications. Respiratory diseases are the main and initial manifestation for the majority of PID patients and most common complication in this group of patients. Pulmonary complications present a significant cause of morbidity and also mortality among patients suffering from different forms of PIDs...
April 27, 2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28443591/clinical-findings-of-pediatric-hiv-infection-at-a-tertiary-center-in-turkey
#7
Murat Sütçü, Manolya Acar, Hacer Aktürk, Selda Hançerli Torun, Hayati Beka, Ali Ağaçfidan, Nuran Salman, Ayper Somer
BACKGROUND: Pediatric HIV infection is different from adult type of disease in many ways including transmission routes, clinical findings and treatment strategies. AIMS: Our aim was to evaluate clinical data of our pediatric HIV patients. STUDY DESIGN: Retrospective cross-sectional study. METHODS: The charts of 22 pediatric patients diagnosed with HIV infection in our clinic during a 14 year period through 2001-2015 were retrospectively analyzed...
April 6, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28440726/expression-of-c-type-lectin-receptor-mrna-in-chronic-otitis-media-with-cholesteatoma
#8
Sang Hoon Kim, Seung-Ho Han, Jae Yong Byun, Moon Suh Park, Young Il Kim, Seung Geun Yeo
CONCLUSIONS: The levels of expression of various C-type lectin receptors (CLRs) messenger ribo nucleic acids (mRNAs) were significantly higher in cholesteatomas than in normal skin, suggesting that these CLRs may be involved in the pathogenesis of cholesteatoma. OBJECTIVES: Altered expression of pattern recognition receptors may be associated with immune responses in patients with cholesteatoma. This study assessed the levels of expression of CLR mRNAs in normal skin and in cholesteatoma...
June 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28431842/significance-of-intraoperative-findings-in-revision-tympanomastoidectomy
#9
Andro Košec, Iva Kelava, Jakov Ajduk, Mihael Ries, Robert Trotić, Vladimir Bedeković
PURPOSE: The study was designed to assess correlations between intraoperative findings in revision tympanomastoidectomy as predictors of cholesteatoma recurrence. MATERIALS AND METHODS: A retrospective single-institution cohort of 101 patients who underwent surgical treatment for recurrent chronic otitis media in a tertiary referral otology centre. RESULTS: Out of 101 patients, 65 had canal wall up and 36 canal wall down revision surgery. There were 35 cholesteatoma recurrences...
April 12, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28403045/polymorphisms-of-mannose-binding-lectin-and-toll-like-receptors-2-3-4-7-and-8-and-the-risk-of-respiratory-infections-and-acute-otitis-media-in-children
#10
Laura Toivonen, Juho Vuononvirta, Jussi Mertsola, Matti Waris, Qiushui He, Ville Peltola
BACKGROUND: Mannose-binding lectin (MBL) and toll-like receptors (TLRs) are important components of the innate immune system. We assessed the susceptibility of children with genetic variants in these factors to respiratory infections, rhinovirus infections and acute otitis media. METHODS: In a prospective cohort study, blood samples from 381 Finnish children were analyzed for polymorphisms in MBL2 at codons 52, 54 and 57, TLR2 Arg753Gln, TLR3 Leu412Phe, TLR4 Asp299Gly, TLR7 Gln11Leu and TLR8 Leu651Leu...
May 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28381402/transcutaneous-immunization-with-a-bandaid-prevents-experimental-otitis-media-in-a-polymicrobial-model
#11
Laura A Novotny, John D Clements, Steven D Goodman, Lauren O Bakaletz
Otitis media (OM) is a common pediatric disease and nontypeable Haemophilus influenzae (NTHI) is the predominant pathogen in chronic OM, recurrent OM and OM associated with treatment failure. OM is also a polymicrobial disease, wherein an upper respiratory tract viral infection predisposes to ascension of NTHI from the nasopharynx, the site of colonization, to the normally sterile middle ear, resulting in disease. Using a clinically relevant viral-bacterial co-infection model of NTHI-induced OM, we performed transcutaneous immunization (TCI) via a bandaid delivery system to administer each of three promising NTHI vaccine candidates derived from bacterial adhesive proteins and biofilm mediators: rsPilA, chimV4 and integration host factor...
April 5, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28372534/panel-7-otitis-media-treatment-and-complications
#12
Anne G M Schilder, Tal Marom, Mahmood F Bhutta, Margaretha L Casselbrant, Harvey Coates, Marie Gisselsson-Solén, Amanda J Hall, Paola Marchisio, Aino Ruohola, Roderick P Venekamp, Ellen M Mandel
Objective We aimed to summarize key articles published between 2011 and 2015 on the treatment of (recurrent) acute otitis media, otitis media with effusion, tympanostomy tube otorrhea, chronic suppurative otitis media and complications of otitis media, and their implications for clinical practice. Data Sources PubMed, Ovid Medline, the Cochrane Library, and Clinical Evidence (BMJ Publishing). Review Methods All types of articles related to otitis media treatment and complications between June 2011 and March 2015 were identified...
April 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28372533/panel-6-vaccines
#13
Melinda M Pettigrew, Mark R Alderson, Lauren O Bakaletz, Stephen J Barenkamp, Anders P Hakansson, Kevin M Mason, Johanna Nokso-Koivisto, Janak Patel, Stephen I Pelton, Timothy F Murphy
Objective To review the literature on progress regarding (1) effectiveness of vaccines for prevention of otitis media (OM) and (2) development of vaccine antigens for OM bacterial and viral pathogens. Data Sources PubMed database of the National Library of Science. Review Methods We performed literature searches in PubMed for OM pathogens and candidate vaccine antigens, and we restricted the searches to articles in English that were published between July 2011 and June 2015. Panel members reviewed literature in their area of expertise...
April 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28372530/panel-5-immunology
#14
Jennelle M Kyd, Muneki Hotomi, Masamitsu Kono, Arwa Kurabi, Michael Pichichero, Allen Ryan, W Edward Swords, Ruth Thornton
Objective To perform a state-of-the-art review of the literature from January 2012 through May 2015 on studies that advanced our knowledge of the innate and adaptive immunology related to otitis media. This review also proposes future directions for research in this area. Data Sources PubMed database of the National Library of Medicine. Review Methods Three subpanels comprising experts in the field focused on sections relevant to cytokines, innate immunity, and adaptive immunity. The review focused on animal, cell line, and human studies and was critical in relation to the recommendations from the previous publication and for determination of the proposed goals and priorities...
April 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28349533/subtotal-petrosectomy-surgical-technique-indications-outcomes-and-comprehensive-review-of-literature
#15
Sampath Chandra Prasad, Valeria Roustan, Gianluca Piras, Antonio Caruso, Lorenzo Lauda, Mario Sanna
OBJECTIVES/HYPOTHESIS: To describe the technique of subtotal petrosectomy (STP), to analyze the outcomes, and to review the literature STUDY DESIGN: A retrospective review. METHODS: Four hundred sixty cases of STP performed for various indications were included in the study, which was conducted at a quaternary referral center for otology and skull base surgery. Surgical and audiological parameters, and complications were evaluated. Our results were compared with the existing literature on the subject...
March 27, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28340091/effect-of-antimicrobial-treatment-on-the-resolution-of-middle-ear-effusion-after-acute-otitis-media
#16
Aino Ruohola, Miia K Laine, Paula A Tähtinen
Background.: Acute otitis media (AOM) induces middle-ear effusion (MEE), which affects hearing. The effect of antimicrobial treatment on the resolution of MEE is controversial, and the factors that affect resolution are unknown. Methods.: We studied the effect of antimicrobial treatment on the time to the resolution of MEE as a secondary objective in our randomized double-blind placebo-controlled trial. Children aged 6 to 35 months with stringently diagnosed AOM were allocated to receive amoxicillin-clavulanate (161 patients) or placebo (158 patients) for 7 days and closely followed for 3 months...
March 16, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28333779/impact-of-chronic-suppurative-otitis-media-in-pediatric-cochlear-implant-recipients-insight-into-the-challenges-from-a-tertiary-referral-center-in-uk
#17
Paramita Baruah, Kate Hanvey, Richard Irving, Konstance Tzifa
OBJECTIVE: Analyze the presentation and evolution of chronic suppurative otitis media (CSOM) in children with cochlear implants (CI) and explore the merit of early intervention. STUDY DESIGN: Retrospective patient review. SETTING: Tertiary referral hospital and cochlear implant programme. PATIENTS: Children with a CI who developed CSOM. INTERVENTION: Tympanoplasty. MAIN OUTCOME MEASURES: Disease control, recurrence of cholesteatoma, cochlear implant preservation...
June 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28322025/prevalence-of-hearing-loss-and-clinical-otologic-manifestations-in-patients-with-22q11-2-deletion-syndrome-a-literature-review
#18
Emmy Verheij, Laura S M Derks, Inge Stegeman, Henricus G X M Thomeer
BACKGROUND: Hearing loss and otitis media are frequently reported in patients with 22q11.2 deletion syndrome. OBJECTIVE OF REVIEW: Our objective was to review the current literature on the prevalence of hearing loss and otologic manifestations in patients with 22q11.2 deletion syndrome. TYPE OF REVIEW: Systematic review. SEARCH STRATEGY: We conducted a systematic search in PubMed and Embase combining the term '22q11...
March 21, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28286158/smith-magenis-syndrome-patients-often-display-antibody-deficiency-but-not-other-immune-pathologies
#19
Tiffany Perkins, Jacob M Rosenberg, Carole Le Coz, Joseph T Alaimo, Melissa Trofa, Sureni V Mullegama, Richard J Antaya, Soma Jyonouchi, Sarah H Elsea, Paul J Utz, Eric Meffre, Neil Romberg
BACKGROUND: Smith-Magenis syndrome (SMS) is a complex neurobehavioral disorder associated with recurrent otitis. Most SMS cases result from heterozygous interstitial chromosome 17p11.2 deletions that encompass not only the intellectual disability gene retinoic acid-induced 1 but also other genes associated with immunodeficiency, autoimmunity, and/or malignancy. OBJECTIVES: The goals of this study were to describe the immunological consequence of 17p11.2 deletions by determining the prevalence of immunological diseases in subjects with SMS and by assessing their immune systems via laboratory methods...
March 9, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28283791/balloon-eustachian-tuboplasty-in-children
#20
A Leichtle, D Hollfelder, B Wollenberg, K-L Bruchhage
Endonasal ballon dilatation of the Eustachian tube (BET) is a promising treatment for Eustachian tube dysfunction with encouraging results over the last years in adults. In addition, in children, single studies demonstrated promising results, but revealed the necessity for broader and additional studies. Our retrospective analysis presents outcomes with BET in children with chronic obstructive dysfunction of the Eustachian tube, showing resistance to the conventional therapy after adenotomy with paracentesis or grommets (ventilation tubes)...
June 2017: European Archives of Oto-rhino-laryngology
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