keyword
MENU ▼
Read by QxMD icon Read
search

fatty acids and insulin-secreting cells

keyword
https://www.readbyqxmd.com/read/29754287/protective-role-of-the-elovl2-docosahexaenoic-acid-axis-in-glucolipotoxicity-induced-apoptosis-in-rodent-beta-cells-and-human-islets
#1
Lara Bellini, Mélanie Campana, Claude Rouch, Marta Chacinska, Marco Bugliani, Kelly Meneyrol, Isabelle Hainault, Véronique Lenoir, Jessica Denom, Julien Véret, Nadim Kassis, Bernard Thorens, Mark Ibberson, Piero Marchetti, Agnieszka Blachnio-Zabielska, Céline Cruciani-Guglielmacci, Carina Prip-Buus, Christophe Magnan, Hervé Le Stunff
AIMS/HYPOTHESIS: Dietary n-3 polyunsaturated fatty acids, especially docosahexaenoic acid (DHA), are known to influence glucose homeostasis. We recently showed that Elovl2 expression in beta cells, which regulates synthesis of endogenous DHA, was associated with glucose tolerance and played a key role in insulin secretion. The present study aimed to examine the role of the very long chain fatty acid elongase 2 (ELOVL2)/DHA axis on the adverse effects of palmitate with high glucose, a condition defined as glucolipotoxicity, on beta cells...
May 12, 2018: Diabetologia
https://www.readbyqxmd.com/read/29754194/loss-of-p2x7-receptor-function-dampens-whole-body-energy-expenditure-and-fatty-acid-oxidation
#2
Giacomo Giacovazzo, Savina Apolloni, Roberto Coccurello
The established role of ATP-responsive P2X7 receptor in inflammatory, neurodegenerative, and immune diseases is now expanding to include several aspects of metabolic dysregulation. Indeed, P2X7 receptors are involved in β cell function, insulin secretion, and liability to diabetes, and loss of P2X7 function may increase the risk of hepatic steatosis and disrupt adipogenesis. Recently, body weight gain, abnormal lipid accumulation, adipocyte hyperplasia, increased fat mass, and ectopic fat distribution have been found in P2X7 KO mice...
May 12, 2018: Purinergic Signalling
https://www.readbyqxmd.com/read/29748290/endogenous-fatty-acids-are-essential-signaling-factors-of-pancreatic-%C3%AE-cells-and-insulin-secretion
#3
Sebastian Hauke, Kaya Keutler, Prasad Phapale, Dmytro A Yushchenko, Carsten Schultz
The secretion of insulin from β -cells depends on extracellular factors, in particular glucose and other small molecules, some of which act on G-protein coupled receptors (GPCRs). Fatty acids (FAs) have been discussed as exogenous secretagogues of insulin for decades, especially after the FA receptor GPR40 was discovered. However, the role of FAs as endogenous signaling factor has not been investigated until now. In the present work, we demonstrate that lowering endogenous FA levels in β -cell medium by stringent washing or by the application of fatty acid-free bovine serum albumin (FAF-BSA) immediately reduced glucose-induced oscillations of cytosolic Ca2+ ([Ca2+ ]i oscillations) in MIN6 and primary β -cells, as well as insulin secretion...
May 10, 2018: Diabetes
https://www.readbyqxmd.com/read/29746655/downregulated-angiopoietin-like-peptide-8-production-at-calving-related-to-changes-in-lipid-metabolism-in-dairy-cows
#4
Misato Nakano, Yutaka Suzuki, Satoshi Haga, Eri Yamauchi, Dahye Kim, Koki Nishihara, K Nakajima, Takafumi Gotoh, Seungju Park, Myunggi Baik, Kazuo Katoh, Sanggun Roh
Acute physiological adaptation of lipid metabolism during the postpartum transition period of cows facilitates peripheral metabolic regulation. Hepatokines, which are hormones secreted from hepatocytes, are presumed to play a critical role in systemic metabolic regulation. Angiopoietin-like protein 8 (ANGPTL8) has been identified as a novel hepatokine associated with circulating triglyceride concentrations in mice and humans. However, regulation of ANGPTL8 and its physiological effects are still unknown in cattle...
May 9, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29718662/high-spatial-resolution-imaging-of-mouse-pancreatic-islets-using-nanospray-desorption-electrospray-ionization-mass-spectrometry
#5
Ruichuan Yin, Jennifer E Kyle, Kristin E Burnum-Johnson, Kent Bloodsworth, Lori Sussel, Charles Ansong, Julia Laskin
Nanospray Desorption Electrospray Ionization mass spectrometry imaging (nano-DESI MSI) enables ambient imaging of biological samples with high sensitivity and minimal sample pretreatment. Recently, we developed an approach for constant-distance mode MSI using shear force microscopy to precisely control the distance between the sample and the nano-DESI probe. Herein, we demonstrate the power of this approach for robust imaging of pancreatic islets with high spatial resolution of ~11 μm. Pancreatic islets are difficult to characterize using traditional mass spectrometry approaches due to their small size (~100 μm) and molecular heterogeneity...
May 2, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29704509/free-fatty-acid-receptor-1-as-a-novel-therapeutic-target-for-type-2-diabetes-mellitus-current-status
#6
REVIEW
Chinedum Eleazu, Ayogu Charles, Kate Eleazu, Ngozi Achi
The incidence of type 2 diabetes mellitus (T2DM) has been on the increase in recent times. Although several oral treatments for T2DM are available, some of them have been found to elicit undesirable side effects. This therefore underscores the need for new treatment options with lesser side effects than the existing ones for people with T2DM. Free fatty acid receptor 1 (FFAR1), also known as GPR40, belongs to a class of G-protein coupled receptors that are encoded by FFAR1 genes in humans. It is expressed in the pancreatic β-cells and it is activated by medium- and long-chain saturated and unsaturated fatty acids...
April 25, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29698923/anti-inflammatory-effects-of-%C3%AE-linolenic-acid-in-m1-like-macrophages-are-associated-with-enhanced-production-of-oxylipins-from-%C3%AE-linolenic-and-linoleic-acid
#7
Samantha D Pauls, Lisa A Rodway, Tanja Winter, Carla G Taylor, Peter Zahradka, Harold M Aukema
Chronic inflammation, mediated in large part by proinflammatory macrophage populations, contributes directly to the induction and perpetuation of metabolic diseases, including obesity, insulin resistance and type 2 diabetes. Polyunsaturated fatty acids (PUFAs) can have profound effects on inflammation through the formation of bioactive oxygenated metabolites called oxylipins. The objective of this study was to determine if exposure to the dietary omega-3 PUFA α-linolenic acid (ALA) can dampen the inflammatory properties of classically activated (M1-like) macrophages derived from the human THP-1 cell line and to examine the accompanying alterations in oxylipin secretion...
April 3, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29687585/bone-another-potential-target-to-treat-prevent-and-predict-diabetes
#8
REVIEW
Dong-Mei Liu, Ioanna Mosialou, Jian-Min Liu
Type 2 diabetes mellitus is now a worldwide health problem with increasing prevalence. Mounting efforts have been made to treat, prevent and predict this chronic disease. In recent years, increasing evidence from mice and clinical studies suggest that bone-derived molecules modulate glucose metabolism. This review aims to summarize our current understanding of the interplay between bone and glucose metabolism and highlight potential new means for therapeutic intervention. The first molecule recognized as a link between bone and glucose metabolism in mice is osteocalcin, which functions in its active form, i...
April 23, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29669317/palmitate-activates-ccl4-expression-in-human-monocytic-cells-via-tlr4-myd88-dependent-activation-of-nf-%C3%AE%C2%BAb-mapk-pi3k-signaling-systems
#9
Shihab Kochumon, Ajit Wilson, Betty Chandy, Steve Shenouda, Jaakko Tuomilehto, Sardar Sindhu, Rasheed Ahmad
BACKGROUND/AIMS: Obesity is associated with adipose tissue inflammation which plays a key role in the development of insulin resistance and type 2 diabetes (T2D). Saturated free fatty acids (SFAs) levels are found to be elevated in obesity and T2D. Chemokines are known to have potent inflammatory functions in a wide range of biological processes linked to immunological disorders. Since CCL4 (Chemokine (C-C motif) ligand 4), also known as macrophage inflammatory protein-1β (MIP-1β), plays an important role in the migration of monocytes into the adipose tissue, we investigated the expression of CCL4 in monocytic cells/macrophages following activation with free fatty acid palmitate...
April 13, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29666215/control-of-pancreatic-%C3%AE-cell-bioenergetics
#10
REVIEW
Charles Affourtit, Ben Alberts, Jonathan Barlow, Jane E Carré, Anthony G Wynne
The canonical model of glucose-stimulated insulin secretion (GSIS) by pancreatic β-cells predicts a glucose-induced rise in the cytosolic ATP/ADP ratio. Such bioenergetic sensitivity to metabolic fuel is unusual as it implies that ATP flux is governed, to a significant extent, by ATP supply, while it is predominantly demand-driven in other cell types. Metabolic control is generally shared between different processes, but potential control of ATP consumption over β-cell bioenergetics has been largely ignored to date...
April 17, 2018: Biochemical Society Transactions
https://www.readbyqxmd.com/read/29649104/coordination-of-gpr40-and-ketogenesis-signaling-by-medium-chain-fatty-acids-regulates-beta-cell-function
#11
Julien Benjamin Pujol, Nicolas Christinat, Yann Ratinaud, Claudia Savoia, Siobhan E Mitchell, El Hadji M Dioum
Diabetes prevalence increases with age, and β-cell dysfunction contributes to the incidence of the disease. Dietary lipids have been recognized as contributory factors in the development and progression of the disease. Unlike long chain triglycerides, medium chain triglycerides (MCT) increase fat burning in animal and human subjects as well as serum C-peptide in type 2 diabetes patients. We evaluated the beneficial effects of MCT on β-cells in vivo and in vitro. MCT improved glycemia in aged rats via β-cell function assessed by measuring insulin secretion and content...
April 12, 2018: Nutrients
https://www.readbyqxmd.com/read/29605320/symposium-review-amino-acid-uptake-by-the-mammary-glands-where-does-the-control-lie
#12
John P Cant, Julie J M Kim, Scott R L Cieslar, John Doelman
Milk protein yield responses to changes in the profile of essential amino acids absorbed by the gastrointestinal tract or circulating in blood plasma do not follow the classic limiting amino acid response, in part because of an ability of the mammary glands to modify their blood flow rate and net clearance of amino acids out of plasma. The hypothesis that mammary blood flow is locally regulated to maintain ATP balance accounts for observed changes in flow due to postruminal glucose, insulin, and essential amino acid (EAA) infusions...
March 28, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29595117/non-alcoholic-fatty-pancreas-disease-nafpd-a-silent-spectator-or-the-fifth-component-of-metabolic-syndrome-a-literature-review
#13
Bhupinder Romana, Harleen Chela, Francis Dailey, Fatiha Nassir, Veysel Tahan
Fat accumulation in the pancreas has remained a relatively unknown disease since it was initially described in 1933. However, it has gained increasing attention in the past two decades with the emergence of the obesity epidemic. Pancreatic steatosis is a general term used for fat accumulation in the pancreas. It is further classified into fatty replacement, fatty infiltration, lipomatous pseudo-hypertrophy, non-alcoholic fatty pancreas disease (NAFPD) and non-alcoholic fatty steatopancreatitis (NASP). NAFPD is defined as obesity-associated accumulation of fat in the pancreas without significant alcohol consumption...
March 27, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29593201/adipose-tissue-critical-contributor-to-the-development-of-prostate-cancer
#14
Uehara Hisanori, Tomoko Kobayashi, Minoru Matsumoto, Shunsuke Watanabe, Akiko Yoneda, Bando Yoshimi
The prostate is surrounded by periprostatic adipose tissue. Although adipose tissue was thought to play limited physiological roles, it has recently been recognized as an active endocrine organ, secreting growth factors and adipokines. Epidemiologically, obesity is associated with prostate cancer progression. A major mechanism to explain the link between obesity and cancer includes the insulin and insulin-like growth factor (IGF)-1 axis, sex steroids, and adipokines. When prostate cancer cells invade periprostatic adipose tissue, adipose tissue contributes to create the tumor microenvironment, mainly via adipokine secretion...
2018: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/29592806/%C3%AE-aminoisobutyric-acid-attenuates-lps-induced-inflammation-and-insulin-resistance-in-adipocytes-through-ampk-mediated-pathway
#15
Tae Woo Jung, Hyung Sub Park, Geum Hee Choi, Daehwan Kim, Taeseung Lee
BACKGROUND: β-aminoisobutyric acid (BAIBA) is produced in skeletal muscle during exercise and has beneficial effects on obesity-related metabolic disorders such as diabetes and non-alcoholic fatty liver disease. Thus, it is supposed to prevent high fat diet (HFD)-induced inflammation and insulin resistance in adipose tissue though anti-inflammatory effects in obesity. Previous reports have also demonstrated strong anti-inflammatory effects of BAIBA. METHODS: We used BAIBA treated fully differentiated 3T3T-L1 mouse adipocytes to investigate the effects of exogenous BAIBA on inflammation and insulin signaling in adipocytes...
March 28, 2018: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29584445/protectin-dx-attenuates-lps-induced-inflammation-and-insulin-resistance-in-adipocytes-via-ampk-mediated-suppression-of-the-nf%C3%AE%C2%BAb-pathway
#16
Tae Woo Jung, Yoon Hee Chung, Hyoung-Chun Kim, A M Abd El-Aty, Ji Hoon Jeong
Several studies have demonstrated that protectins, which are ω-3 fatty acid-derived proresolution mediators, may ameliorate inflammation. Recently, protectin DX (PDX) was also reported to attenuate inflammation and insulin resistance in several cell types. However, the effects of PDX on inflammation in adipocytes remain unclear. In this study, we found that PDX treatment suppressed adipogenesis as well as lipid accumulation during 3T3-L1 differentiation. Treatment of differentiated 3T3-L1 cells with PDX stimulated AMP-activated protein kinase (AMPK) phosphorylation in a dose-dependent manner...
March 27, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29578696/a-microfluidic-chip-with-integrated-electrophoretic-immunoassay-for-investigating-cell-cell-interactions
#17
Shusheng Lu, Colleen E Dugan, Robert T Kennedy
Microfluidics have been used to create "body-on-chip" systems to mimic in vivo cellular interactions with a high level of control. Most such systems rely on optical observation of cells as a readout. In this work we integrated a cell-cell interaction chip with on-line microchip electrophoresis immunoassay to monitor the effects of the interaction on protein secretion dynamics. The system was used to investigate the effects of adipocytes on insulin secretion. Chips were loaded with 190,000 3T3-L1 adipocytes and a single islet of Langerhans in separate chambers...
March 26, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29566909/nafld-helicobacter-species-and-the-intestinal-microbiome
#18
REVIEW
Natalia Castaño-Rodríguez, Hazel M Mitchell, Nadeem O Kaakoush
Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease worldwide. It is well-accepted that gut dysbiosis is associated with NAFLD, however, there is some conflicting evidence regarding the nature of these alterations. Infection with Helicobacter species, mainly H. pylori, has also been associated with increased NAFLD risk, however, some studies have failed to reproduce this finding. Further studies including large study samples and standardised procedures for microbiota analyses, H...
December 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/29546329/metabolomics-identifies-distinctive-metabolite-signatures-for-measures-of-glucose-homeostasis-the-insulin-resistance-atherosclerosis-family-study-iras-fs
#19
Nicholette D Palmer, Hayrettin Okut, Fang-Chi Hsu, Maggie C Y Ng, Yii-Der Ida Chen, Mark O Goodarzi, Kent D Taylor, Jill M Norris, Carlos Lorenzo, Jerome I Rotter, Richard N Bergman, Carl D Langefeld, Lynne E Wagenknecht, Donald W Bowden
Context: Metabolomics provides a biochemical fingerprint that, when coupled with clinical phenotypes, can provide insight into physiological processes. Objective: Survey metabolites associated with dynamic and basal measures of glucose homeostasis. Design: Analysis of 733 plasma metabolites from the Insulin Resistance Atherosclerosis Family Study. Setting: Community based. Participants: One thousand one hundred eleven Mexican Americans...
May 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29537934/the-role-of-polyunsaturated-fatty-acids-n-3-pufas-on-the-pancreatic-%C3%AE-cells-and-insulin-action
#20
Habtamu Wondifraw Baynes, Seifu Mideksa, Sintayehu Ambachew
Polyunsaturated Fatty acids have multiple effects in peripheral tissues and pancreatic beta cell function. The n-3 Polyunsaturated Fatty acids prevent and reverse high-fat-diet induced adipose tissue inflammation and insulin resistance. Insulin secretion is stimulated by glucose, amino acids, and glucagon- like peptide-1 in tissue containing high levels of n-3 Polyunsaturated Fatty acids than lower level of n-3 Polyunsaturated Fatty acids. Also, n-3 Polyunsaturated Fatty acids led to decreased production of prostaglandin, which in turn contributed to the elevation of insulin secretion...
March 14, 2018: Adipocyte
keyword
keyword
95477
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"