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https://www.readbyqxmd.com/read/28794016/serine-protease-inhibitor-serpinb2-binds-and-stabilizes-p21-in-senescent-cells
#1
Hsi-Hsien Hsieh, Ying-Chieh Chen, Jing-Ru Jhan, Jing-Jer Lin
SerpinB2 is a serine protease inhibitor that is also known as plasminogen activator inhibitor type 2 (PAI-2). It has been well documented that SerpinB2 is an inhibitor of urokinase plasminogen activator (uPA) and tissue plasminogen activator (tPA). Interestingly, SerpinB2 level is increased in senescent cells and is considered a senescence biomarker. Through mimicking the elevated level of SerpinB2 in senescent cells, this study showed the proliferating human fibroblasts were induced into senescence. Senescence induced by SerpinB2 did not relate to its extracellular function as inhibition of SerpinB2 secretion, exogenous introduced SerpinB2, or a SerpinB2 mutant that failed to bind to its extracellular target uPA, did not have an effect on senescence...
August 9, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28416743/the-urokinase-plasminogen-activation-system-in-gastroesophageal-cancer-a-systematic-review-and-meta-analysis
#2
Daniel Brungs, Julia Chen, Morteza Aghmesheh, Kara L Vine, Therese M Becker, Martin G Carolan, Marie Ranson
BACKGROUND: The urokinase plasminogen activation (uPA) system is a crucial pathway for tumour invasion and establishment of metastasis. Although there is good evidence that uPA system expression is a clinically relevant biomarker in some solid tumours, its role in gastroesophageal cancer is uncertain. RESULTS: We identified 22 studies encompassing 1966 patients which fulfilled the inclusion criteria. uPA, uPAR, or PAI-1 expression is significantly associated with high risk clinicopathological features...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28347342/identification-and-analysis-of-genomic-islands-in-burkholderia-cenocepacia-au-1054-with-emphasis-on-pathogenicity-islands
#3
Feng-Biao Guo, Lifeng Xiong, Kai-Yue Zhang, Chuan Dong, Fa-Zhan Zhang, Patrick C Y Woo
BACKGROUND: Genomic islands (GIs) are genomic regions that reveal evidence of horizontal DNA transfer. They can code for many functions and may augment a bacterium's adaptation to its host or environment. GIs have been identified in strain J2315 of Burkholderia cenocepacia, whereas in strain AU 1054 there has been no published works on such regions according to our text mining and keyword search in Medline. RESULTS: In this study, we identified 21 GIs in AU 1054 by combining two computational tools...
March 27, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28289240/pais-2-paracetamol-acetaminophen-in-stroke-2-results-of-a-randomized-double-blind-placebo-controlled-clinical-trial
#4
RANDOMIZED CONTROLLED TRIAL
Inger R de Ridder, Heleen M den Hertog, H Maarten A van Gemert, A H C M L Tobien Schreuder, Annemieke Ruitenberg, E Lisette Maasland, Ritu Saxena, Jordie H van Tuijl, Ben P W Jansen, Renske M Van den Berg-Vos, Frederique Vermeij, Peter J Koudstaal, L Jaap Kappelle, Ale Algra, H Bart van der Worp, Diederik W J Dippel
BACKGROUND AND PURPOSE: Subfebrile body temperature and fever in the first days after stroke are strongly associated with unfavorable outcome. A subgroup analysis of a previous trial suggested that early treatment with paracetamol may improve functional outcome in patients with acute stroke and a body temperature of ≥36.5°C. In the present trial, we aimed to confirm this finding. METHODS: PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2) was a multicenter, randomized, double-blind, placebo-controlled clinical trial...
April 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28218959/survival-and-periapical-health-after-root-canal-treatment-with-carrier-based-root-fillings-5-year-retrospective-assessment
#5
C Pirani, S Friedman, M R Gatto, F Iacono, V Tinarelli, M G Gandolfi, C Prati
AIM: This retrospective study explored survival and periapical healing outcomes in root filled teeth with Thermafil obturators. METHODOLOGY: Root canals of 213 teeth (94 subjects, mean age 48±13 years), instrumented with a step-down technique, irrigated with 5% NaOCl and 10% EDTA and filled with Thermafil and AH-Plus sealer, were involved in a Recall programme. Teeth were retrospectively reexamined after 5±1 years in a controlled environment. Clinical and radiographic data that were collected included: preoperative Periapical Index (PAI) score and signs/symptoms, treatment type, root filling length and presence/absence of voids, restoration type, follow-up PAI score and signs/symptoms...
February 20, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/27956714/auranofin-suppresses-plasminogen-activator-inhibitor-2-expression-through-annexin-a5-induction-in-human-prostate-cancer-cells
#6
Dong-Won Shin, Yeo-Jung Kwon, Dong-Jin Ye, Hyoung-Seok Baek, Joo-Eun Lee, Young-Jin Chun
Auranofin has been developed as antirheumatic drugs, which is currently under clinical development for the treatment of chronic lymphocytic leukemia. Previous report showed that auranofin induced apoptosis by enhancement of annexin A5 expression in PC-3 cells. To understand the role of annexin A5 in auranofin-mediated apoptosis, we performed microarray data analysis to study annexin A5-controlled gene expression in annexin A5 knockdown PC-3 cells. Of differentially expressed genes, plasminogen activator inhibitor (PAI)-2 was increased by annexin A5 siRNA confirmed by qRT-PCR and western blot...
March 1, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/27813404/high-throughput-discovery-of-aptamers-for-sandwich-assays
#7
Andrew T Csordas, Anna Jørgensen, Jinpeng Wang, Emily Gruber, Qiang Gong, Elizabeth R Bagley, Margaret A Nakamoto, Michael Eisenstein, H Tom Soh
Sandwich assays are among the most powerful tools in molecular detection. These assays use "pairs" of affinity reagents so that the detection signal is generated only when both reagents bind simultaneously to different sites on the target molecule, enabling highly sensitive and specific measurements in complex samples. Thus, the capability to efficiently screen affinity reagent pairs at a high throughput is critical. In this work, we describe an experimental strategy for screening "aptamer pairs" at a throughput of 10(6) aptamer pairs per hour-which is many orders of magnitude higher than the current state of the art...
November 15, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27781272/gingival-crevicular-fluid-tissue-blood-vessel-type-plasminogen-activator-and-plasminogen-activator-inhibitor-2-levels-in-patients-with-rheumatoid-arthritis-effects-of-nonsurgical-periodontal-therapy
#8
Ş Kurgan, C Önder, N Balcı, Ö Fentoğlu, F Eser, M Balseven, M A Serdar, D N Tatakis, M Günhan
BACKGROUND AND OBJECTIVE: The aim of this study was to evaluate the effect of nonsurgical periodontal therapy on clinical parameters and gingival crevicular fluid levels of tissue/blood vessel-type plasminogen activator (t-PA) and plasminogen activator inhibitor-2 (PAI-2) in patients with periodontitis, with or without rheumatoid arthritis (RA). MATERIAL AND METHODS: Fifteen patients with RA and chronic periodontitis (RA-P), 15 systemically healthy patients with chronic periodontitis (H-P) and 15 periodontally and systemically healthy volunteers (C) were included in the study...
June 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/27694320/polyphosphate-colocalizes-with-factor-xii-on-platelet-bound-fibrin-and-augments-its-plasminogen-activator-activity
#9
Joanne L Mitchell, Ausra S Lionikiene, Georgi Georgiev, Anja Klemmer, Chelsea Brain, Paul Y Kim, Nicola J Mutch
Activated factor XII (FXIIa) has plasminogen activator capacity but its relative contribution to fibrinolysis is considered marginal compared with urokinase and tissue plasminogen activator. Polyphosphate (polyP) is released from activated platelets and mediates FXII activation. Here, we investigate the contribution of polyP to the plasminogen activator function of αFXIIa. We show that both polyP70, of the chain length found in platelets (60-100 mer), and platelet-derived polyP significantly augment the plasminogen activation capacity of αFXIIa...
December 15, 2016: Blood
https://www.readbyqxmd.com/read/27660159/a-clinical-study-on-single-visit-root-canal-retreatments-on-consecutive-173-patients-frequency-of-periapical-complications-and-clinical-success-rate
#10
Tan Firat Eyuboglu, Kezban Olcay, Mutlu Özcan
OBJECTIVES: This study assessed the outcome measures of single-visit root canal retreatments and frequency of periapical complications considering preoperative, intraoperative and postoperative factors. MATERIALS AND METHODS: Between November 2011 and December 2012, in 173 patients, a total of 234 endodontically treated teeth were retreated in a single appointment by one experienced endodontist. Five teeth were extracted and 119 teeth were lost to follow-up yielding to 110 teeth (47 %) to be examined by two calibrated examiners for the outcome of healing (periapical index score-PAI ≤2; no signs or symptoms) or non-healing (presence of apical periodontitis-PAI >2; signs or symptoms)...
June 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27644043/circulating-fibronectin-and-plasminogen-activator-inhibitor-2-levels-as-possible-predictors-of-recurrent-placental-syndrome-an-exploratory-study
#11
Carmen A H Severens-Rijvers, Salwan Al-Nasiry, Chahinda Ghossein-Doha, Sara Marzano, Hugo Ten Cate, Bjorn Winkens, Marc A E Spaanderman, Louis L H Peeters
BACKGROUND/AIM: Placental syndromes (PS) are characterized by endothelial dysfunction complicating placental dysfunction. Possible markers for endothelial dysfunction and amount of trophoblast are fibronectin and plasminogen activator inhibitor-2 (PAI-2), respectively. We aimed (1) to determine whether in women with recurrent PS (rPS), this complication is preceded by deviating fibronectin- and PAI-2-levels, and (2) whether this is dependent on pre-pregnant plasma volume (PV). METHODS: In 36 former patients, we determined fibronectin- and PAI-2-levels in blood-samples collected preconceptionally and at 12-16 weeks in their next pregnancy...
2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27600972/leucocyte-expression-of-genes-implicated-in-the-plasminogen-activation-cascade-is-modulated-by-yoghurt-peptides
#12
COMPARATIVE STUDY
Georgios Theodorou, Ioannis Politis
The urokinase-plasminogen activator (u-PA), its receptor (u-PAR) and the inhibitors of u-PA (PAI-1 and PAI-2) provide a multi-molecular system in leucocytes that exerts pleiotropic functions influencing the development of inflammatory and immune responses. The objective of the present study was to examine the ability of water soluble extracts (WSE) obtained from traditional Greek yoghurt made from bovine or ovine milk to modulate the expression of u-PA, u-PAR, PAI-1 and PAI-2 in ovine monocytes and neutrophils...
August 2016: Journal of Dairy Research
https://www.readbyqxmd.com/read/27598010/fibrinolysis-parameters-in-sudanese-women-with-severe-preeclampsia
#13
Husham O Elzein, Abdel Rahim M Muddathir, Mohammed Rida, Duria A Rayis, Elhassan M Elhassan, Ishag Adam
BACKGROUND: Although preeclampsia remains a major cause of maternal and fetal morbidity and mortality, its pathogenesis is not fully understood. Coagulation and fibrinolysis changes were suggested to have a role in the pathogenesis of preeclampsia. OBJECTIVES: A case-control study was conducted in Medani Hospital, Sudan, to investigate thrombin-activatable fibrinolysis inhibitor (TAFI) and plasminogen-activated inhibitor (PAI) in women with severe preeclampsia. Obstetrics and medical history was gathered using questionnaire...
November 2016: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/27554634/pzp-and-pai-2-structurally-diverse-functionally-similar-pregnancy-proteins
#14
Amy R Wyatt, Jordan H Cater, Marie Ranson
Pregnancy zone protein (PZP) and plasminogen activator inhibitor type 2 (PAI-2) are two multifunctional proteins that are elevated in normal pregnancy and numerous other inflammatory states. Both proteins were originally identified as protease inhibitors, but current evidence supports the notion that they may also function as modulators of T-helper cells and/or extracellular chaperones. Exacerbated inflammation, fibrinolytic disturbances and misfolded proteins are all implicated in the pathology of preeclampsia, a leading cause of maternal and foetal mortality and morbidity...
October 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27412942/-xinfeng-capsule-improves-hypercoagulative-state-by-inhibiting-mir-155-nf-%C3%AE%C2%BAb-signaling-pathway-in-patients-with-active-ankylosing-spondylitis
#15
RANDOMIZED CONTROLLED TRIAL
Li Fang, Jian Liu, Lei Wan, Fubing Zhu, Bing Tan, Pingheng Zhang
Objective To observe the effect of Xinfeng capsule (XFC) on miR-155, nuclear factor kappa B (NF-κB) signal pathway, and indexes related to hypercoagulative state in patients with active ankylosing spondylitis (AS), and investigate the possible mechanism. Methods Fifty-six cases in active AS were randomly divided into XFC group and sulfasalazine (SASP) group. All cases in the XFC group took three capsules three times daily for twelve consecutive weeks. The ones in the SASP group took four tablets two times daily for twelve consecutive weeks...
August 2016: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/27345498/is-there-a-role-for-urokinase-type-plasminogen-activator-inhibitors-as-maintenance-therapy-in-patients-with-ovarian-cancer
#16
REVIEW
P A van Dam, A Coelho, C Rolfo
There is abundant evidence that the urokinase-type plasminogen activator (uPA), its inhibitors PAI-1 and PAI-2 (plasminogen activator inhibitor type-1 and type-2) and its cells surface receptor (uPA-R, CD87) play a fundamental role in tumor invasion and metastasis and are of significant prognostic significance for many tumor types. We performed a systematic Med-line search on uPA, PAI, uPA-R and (epithelial) ovarian cancer (EOC). The majority of malignant EOC specimens show moderate to strong immunostating of tumor and stromal cells...
February 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27295389/pai-2-serpinb2-inhibits-proteolytic-activity-in-a-p-gingivalis-dominated-multispecies-bacterial-consortium
#17
Jessica Neilands, Floris J Bikker, Bertil Kinnby
OBJECTIVE: The aim of this study was to investigate the ability of the serine protease inhibitor plasminogen activator inhibitor type 2 (PAI-2/Serpin B2) to inhibit proteases produced by a multispecies bacterial consortium in vitro. BACKGROUND: Gingival and periodontal inflammation is associated with an increased flow of protein-rich gingival fluid. This nutritional change in the microenvironment favors bacteria with a proteolytic phenotype, triggering inflammation and associated tissue breakdown...
October 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/27284570/data-in-support-of-a-central-role-of-plasminogen-activator-inhibitor-2-polymorphism-in-recurrent-cardiovascular-disease-risk-in-the-setting-of-high-hdl-cholesterol-and-c-reactive-protein-using-bayesian-network-modeling
#18
James P Corsetti, Peter Salzman, Dan Ryan, Arthur J Moss, Wojciech Zareba, Charles E Sparks
Data is presented that was utilized as the basis for Bayesian network modeling of influence pathways focusing on the central role of a polymorphism of plasminogen activator inhibitor-2 (PAI-2) on recurrent cardiovascular disease risk in patients with high levels of HDL cholesterol and C-reactive protein (CRP) as a marker of inflammation, "Influences on Plasminogen Activator Inhibitor-2 Polymorphism-Associated Recurrent Cardiovascular Disease Risk in Patients with High HDL Cholesterol and Inflammation" (Corsetti et al...
September 2016: Data in Brief
https://www.readbyqxmd.com/read/27174532/influences-on-plasminogen-activator-inhibitor-2-polymorphism-associated-recurrent-cardiovascular-disease-risk-in-patients-with-high-hdl-cholesterol-and-inflammation
#19
James P Corsetti, Peter Salzman, Dan Ryan, Arthur J Moss, Wojciech Zareba, Charles E Sparks
BACKGROUND AND AIMS: Evidence continues to accumulate that athero-protective effects of high-density lipoprotein (HDL) depend to some degree on effective HDL functionality and that such functionality can become degraded in the setting of chronic inflammation. To investigate this issue, we have studied a group of post-myocardial infarction patients with high levels of C-reactive protein as an indicator of chronic inflammation and with concurrently high levels of HDL cholesterol. For these patients we have demonstrated high-risk for recurrent cardiac events as well as a strong association of risk with a polymorphism of the gene (SERPINB2) for plasminogen activator inhibitor-2 (PAI-2) presumptively reflective of an important role for fibrinolysis in risk...
July 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27144072/single-versus-multi-visit-endodontic-treatment-of-teeth-with-apical-periodontitis-an-in-vivo-study-with-1-year-evaluation
#20
G S Gill, A C Bhuyan, C Kalita, L Das, R Kataki, D Bhuyan
BACKGROUND: Apical periodontitis (AP) is one of the most prevalent diseases of the teeth. Treatment of AP is based on the removal of the cause, i.e., bacteria from the root canals. Achievement of adequate bacterial eradication in one appointment treatment remains a controversy. AIM: This prospective study was conducted with the objective to compare the periapical healing of teeth with AP treated in (a) single visit versus (b) two visits, either with or without Vitapex as an intracanal medicament...
January 2016: Annals of Medical and Health Sciences Research
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