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https://www.readbyqxmd.com/read/29603299/efficacy-of-chlorhexidine-as-a-final-irrigant-in-one-visit-root-canal-treatment-a-prospective-comparative-study
#1
S Miçooğullar Kurt, M K Çalışkan
AIM: To evaluate postoperative pain and radiographic evidence of periapical healing in teeth with apical periodontitis treated in one visit with an additional final irrigation using 2% chlorhexidine (CHX) and to compare the results with conventional two-visit root canal treatment (RCT) with an intracanal calcium hydroxide (CH) dressing as a control group. METHODOLOGY: Ninety asymptomatic maxillary anterior teeth with periapical lesions were treated by a single operator...
March 30, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29577949/quantification-of-ligand-density-and-stoichiometry-on-the-surface-of-liposomes-using-single-molecule-fluorescence-imaging
#2
Lisa Belfiore, Lisanne M Spenkelink, Marie Ranson, Antoine M van Oijen, Kara L Vine
Despite the longstanding existence of liposome technology in drug delivery applications, there have been no ligand-directed liposome formulations approved for clinical use to date. This lack of translation is due to several factors, one of which is the absence of molecular tools available for the robust quantification of ligand density on the surface of liposomes. We report here for the first time the quantification of proteins attached to the surface of small unilamellar liposomes using single-molecule fluorescence imaging...
March 22, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29484286/multifaceted-role-of-the-urokinase-type-plasminogen-activator-upa-and-its-receptor-upar-diagnostic-prognostic-and-therapeutic-applications
#3
REVIEW
Niaz Mahmood, Catalin Mihalcioiu, Shafaat A Rabbani
The plasminogen activator (PA) system is an extracellular proteolytic enzyme system associated with various physiological and pathophysiological processes. A large body of evidence support that among the various components of the PA system, urokinase-type plasminogen activator (uPA), its receptor (uPAR), and plasminogen activator inhibitor-1 and -2 (PAI-1 and PAI-2) play a major role in tumor progression and metastasis. The binding of uPA with uPAR is instrumental for the activation of plasminogen to plasmin, which in turn initiates a series of proteolytic cascade to degrade the components of the extracellular matrix, and thereby, cause tumor cell migration from the primary site of origin to a distant secondary organ...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29432651/a-20-year-historical-prospective-cohort-study-of-root-canal-treatments-a-multilevel-analysis
#4
C Prati, C Pirani, F Zamparini, M R Gatto, M G Gandolfi
AIM: To evaluate the number of healthy and functional root filled teeth of patients included in a recall programme for at least 20 years. METHODOLOGY: Teeth were root filled by a single specialist following manual canal instrumentation, lateral/vertical compaction of gutta-percha and restored with glass-ionomer cements and bonding system/composite resin. In a large percentage of teeth, a metal-ceramic crown was placed during follow-up. Patients included in the recall programme (n = 130) were blindly assessed both clinically and radiographically (every 2 years) to evaluate clinical symptoms and periapical status (PAI)...
February 12, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29387404/prognostic-value-of-urokinase-plasminogen-activator-system-in-non-small-cell-lung-cancer-a-systematic-review-and-meta-analysis
#5
Jia-Ju Lu, Hong Guo, Bo Gao, Yun Zhang, Qing-Ling Lin, Jiang Shi, Jing-Jing Liu, Jian Liu
Current relevant research suggests there are significant differences between the expression of the urokinase plasminogen activator (uPA) system in cancer tissues and in normal tissues. However, the potential effectiveness of the uPA system as a prognostic biomarker of non-small cell lung cancer (NSCLC) remains unclear. In the present study, a systematic review and meta-analysis were performed to evaluate the relevance of the uPA system in the prognosis of patients with NSCLC. Using the PubMed, EMBASE, Web of Science and Cochrane Library databases, data from relevant academic journal articles were extracted and subjected to analysis...
January 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29347950/the-microrna-15a-pai-2-axis-in-cholangiocarcinoma-associated-fibroblasts-promotes-migration-of-cancer-cells
#6
Penkhae Utaijaratrasmi, Kulthida Vaeteewoottacharn, Takaaki Tsunematsu, Pranisa Jamjantra, Sopit Wongkham, Chawalit Pairojkul, Narong Khuntikeo, Naozumi Ishimaru, Yongyut Sirivatanauksorn, Ananya Pongpaibul, Peti Thuwajit, Chanitra Thuwajit, Yasusei Kudo
BACKGROUND: Cholangiocarcinoma (CCA) has an abundance of tumor stroma which plays an important role in cancer progression via tumor-promoting signals. This study aims to explore the microRNA (miRNA) profile of CCA-associated fibroblasts (CCFs) and the roles of any identified miRNAs in CCA progression. METHODS: miRNA expression profiles of CCFs and normal skin fibroblasts were compared by microarray. Identified downregulated miRNAs and their target genes were confirmed by real-time PCR...
January 18, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29336491/effect-of-sex-steroid-hormone-fluctuations-in-the-pathophysiology-of-male-retinal-pigment-epithelial-cells
#7
Carlo Astarita, Barbara D'Angelo-Maansson, Mina Massaro-Giordano, Maria P Alba, Silvia Boffo, Ilaria Macchi, Antonio Giordano, Marcella Macaluso
Gender-based differences may influence the occurrence of several ocular conditions suggesting the possibility that fluctuations in sex steroid homeostasis may have direct effects on the eye physiology. Here, we evaluated the effect of sex steroid hormone fluctuations in male retinal pigment epithelial cells, RPEs (ARPE-19). To mimic hormonal fluctuations occurring during aging, we exposed ARPE-19 to acute, prolonged or chronic estradiol, and progesterone challenges. We found that chronic estradiol treatment promotes a remarkable necrosis of RPE cells, and does not affect pRb2/p130 or PAI-2 sub-cellular localization...
January 16, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28794016/the-serine-protease-inhibitor-serpinb2-binds-and-stabilizes-p21-in-senescent-cells
#8
Hsi-Hsien Hsieh, Ying-Chieh Chen, Jing-Ru Jhan, Jing-Jer Lin
SerpinB2 is a serine protease inhibitor also known as plasminogen activator inhibitor type 2 (PAI-2). It has been well documented that serpinB2 is an inhibitor of urokinase plasminogen activator (uPA) and tissue plasminogen activator (tPA). Interestingly, serpinB2 levels are increased in senescent cells and serpinB2 is thus considered a senescence biomarker. In this study, by mimicking the elevated levels of serpinB2 in senescent cells, proliferating human fibroblasts were induced into senescence. Senescence induced by serpinB2 did not relate to its extracellular function, as inhibition of serpinB2 secretion, exogenous introduced serpinB2, or a serpinB2 mutant that failed to bind to its extracellular target uPA did not affect senescence...
October 1, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28416743/the-urokinase-plasminogen-activation-system-in-gastroesophageal-cancer-a-systematic-review-and-meta-analysis
#9
REVIEW
Daniel Brungs, Julia Chen, Morteza Aghmesheh, Kara L Vine, Therese M Becker, Martin G Carolan, Marie Ranson
BACKGROUND: The urokinase plasminogen activation (uPA) system is a crucial pathway for tumour invasion and establishment of metastasis. Although there is good evidence that uPA system expression is a clinically relevant biomarker in some solid tumours, its role in gastroesophageal cancer is uncertain. RESULTS: We identified 22 studies encompassing 1966 patients which fulfilled the inclusion criteria. uPA, uPAR, or PAI-1 expression is significantly associated with high risk clinicopathological features...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28347342/identification-and-analysis-of-genomic-islands-in-burkholderia-cenocepacia-au-1054-with-emphasis-on-pathogenicity-islands
#10
Feng-Biao Guo, Lifeng Xiong, Kai-Yue Zhang, Chuan Dong, Fa-Zhan Zhang, Patrick C Y Woo
BACKGROUND: Genomic islands (GIs) are genomic regions that reveal evidence of horizontal DNA transfer. They can code for many functions and may augment a bacterium's adaptation to its host or environment. GIs have been identified in strain J2315 of Burkholderia cenocepacia, whereas in strain AU 1054 there has been no published works on such regions according to our text mining and keyword search in Medline. RESULTS: In this study, we identified 21 GIs in AU 1054 by combining two computational tools...
March 27, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28289240/pais-2-paracetamol-acetaminophen-in-stroke-2-results-of-a-randomized-double-blind-placebo-controlled-clinical-trial
#11
RANDOMIZED CONTROLLED TRIAL
Inger R de Ridder, Heleen M den Hertog, H Maarten A van Gemert, A H C M L Tobien Schreuder, Annemieke Ruitenberg, E Lisette Maasland, Ritu Saxena, Jordie H van Tuijl, Ben P W Jansen, Renske M Van den Berg-Vos, Frederique Vermeij, Peter J Koudstaal, L Jaap Kappelle, Ale Algra, H Bart van der Worp, Diederik W J Dippel
BACKGROUND AND PURPOSE: Subfebrile body temperature and fever in the first days after stroke are strongly associated with unfavorable outcome. A subgroup analysis of a previous trial suggested that early treatment with paracetamol may improve functional outcome in patients with acute stroke and a body temperature of ≥36.5°C. In the present trial, we aimed to confirm this finding. METHODS: PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2) was a multicenter, randomized, double-blind, placebo-controlled clinical trial...
April 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28218959/survival-and-periapical-health-after-root-canal-treatment-with-carrier-based-root-fillings-5-year-retrospective-assessment
#12
C Pirani, S Friedman, M R Gatto, F Iacono, V Tinarelli, M G Gandolfi, C Prati
AIM: This retrospective study explored survival and periapical healing outcomes in root filled teeth with Thermafil obturators. METHODOLOGY: Root canals of 213 teeth (94 subjects, mean age 48±13 years), instrumented with a step-down technique, irrigated with 5% NaOCl and 10% EDTA and filled with Thermafil and AH-Plus sealer, were involved in a Recall programme. Teeth were retrospectively reexamined after 5±1 years in a controlled environment. Clinical and radiographic data that were collected included: preoperative Periapical Index (PAI) score and signs/symptoms, treatment type, root filling length and presence/absence of voids, restoration type, follow-up PAI score and signs/symptoms...
February 20, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/27956714/auranofin-suppresses-plasminogen-activator-inhibitor-2-expression-through-annexin-a5-induction-in-human-prostate-cancer-cells
#13
Dong-Won Shin, Yeo-Jung Kwon, Dong-Jin Ye, Hyoung-Seok Baek, Joo-Eun Lee, Young-Jin Chun
Auranofin has been developed as antirheumatic drugs, which is currently under clinical development for the treatment of chronic lymphocytic leukemia. Previous report showed that auranofin induced apoptosis by enhancement of annexin A5 expression in PC-3 cells. To understand the role of annexin A5 in auranofin-mediated apoptosis, we performed microarray data analysis to study annexin A5-controlled gene expression in annexin A5 knockdown PC-3 cells. Of differentially expressed genes, plasminogen activator inhibitor (PAI)-2 was increased by annexin A5 siRNA confirmed by qRT-PCR and western blot...
March 1, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/27813404/high-throughput-discovery-of-aptamers-for-sandwich-assays
#14
Andrew T Csordas, Anna Jørgensen, Jinpeng Wang, Emily Gruber, Qiang Gong, Elizabeth R Bagley, Margaret A Nakamoto, Michael Eisenstein, H Tom Soh
Sandwich assays are among the most powerful tools in molecular detection. These assays use "pairs" of affinity reagents so that the detection signal is generated only when both reagents bind simultaneously to different sites on the target molecule, enabling highly sensitive and specific measurements in complex samples. Thus, the capability to efficiently screen affinity reagent pairs at a high throughput is critical. In this work, we describe an experimental strategy for screening "aptamer pairs" at a throughput of 10(6) aptamer pairs per hour-which is many orders of magnitude higher than the current state of the art...
November 15, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27781272/gingival-crevicular-fluid-tissue-blood-vessel-type-plasminogen-activator-and-plasminogen-activator-inhibitor-2-levels-in-patients-with-rheumatoid-arthritis-effects-of-nonsurgical-periodontal-therapy
#15
Ş Kurgan, C Önder, N Balcı, Ö Fentoğlu, F Eser, M Balseven, M A Serdar, D N Tatakis, M Günhan
BACKGROUND AND OBJECTIVE: The aim of this study was to evaluate the effect of nonsurgical periodontal therapy on clinical parameters and gingival crevicular fluid levels of tissue/blood vessel-type plasminogen activator (t-PA) and plasminogen activator inhibitor-2 (PAI-2) in patients with periodontitis, with or without rheumatoid arthritis (RA). MATERIAL AND METHODS: Fifteen patients with RA and chronic periodontitis (RA-P), 15 systemically healthy patients with chronic periodontitis (H-P) and 15 periodontally and systemically healthy volunteers (C) were included in the study...
June 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/27694320/polyphosphate-colocalizes-with-factor-xii-on-platelet-bound-fibrin-and-augments-its-plasminogen-activator-activity
#16
Joanne L Mitchell, Ausra S Lionikiene, Georgi Georgiev, Anja Klemmer, Chelsea Brain, Paul Y Kim, Nicola J Mutch
Activated factor XII (FXIIa) has plasminogen activator capacity but its relative contribution to fibrinolysis is considered marginal compared with urokinase and tissue plasminogen activator. Polyphosphate (polyP) is released from activated platelets and mediates FXII activation. Here, we investigate the contribution of polyP to the plasminogen activator function of αFXIIa. We show that both polyP70 , of the chain length found in platelets (60-100 mer), and platelet-derived polyP significantly augment the plasminogen activation capacity of αFXIIa...
December 15, 2016: Blood
https://www.readbyqxmd.com/read/27660159/a-clinical-study-on-single-visit-root-canal-retreatments-on-consecutive-173-patients-frequency-of-periapical-complications-and-clinical-success-rate
#17
Tan Firat Eyuboglu, Kezban Olcay, Mutlu Özcan
OBJECTIVES: This study assessed the outcome measures of single-visit root canal retreatments and frequency of periapical complications considering preoperative, intraoperative and postoperative factors. MATERIALS AND METHODS: Between November 2011 and December 2012, in 173 patients, a total of 234 endodontically treated teeth were retreated in a single appointment by one experienced endodontist. Five teeth were extracted and 119 teeth were lost to follow-up yielding to 110 teeth (47 %) to be examined by two calibrated examiners for the outcome of healing (periapical index score-PAI ≤2; no signs or symptoms) or non-healing (presence of apical periodontitis-PAI >2; signs or symptoms)...
June 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27644043/circulating-fibronectin-and-plasminogen-activator-inhibitor-2-levels-as-possible-predictors-of-recurrent-placental-syndrome-an-exploratory-study
#18
Carmen A H Severens-Rijvers, Salwan Al-Nasiry, Chahinda Ghossein-Doha, Sara Marzano, Hugo Ten Cate, Bjorn Winkens, Marc A E Spaanderman, Louis L H Peeters
BACKGROUND/AIM: Placental syndromes (PS) are characterized by endothelial dysfunction complicating placental dysfunction. Possible markers for endothelial dysfunction and amount of trophoblast are fibronectin and plasminogen activator inhibitor-2 (PAI-2), respectively. We aimed (1) to determine whether in women with recurrent PS (rPS), this complication is preceded by deviating fibronectin- and PAI-2-levels, and (2) whether this is dependent on pre-pregnant plasma volume (PV). METHODS: In 36 former patients, we determined fibronectin- and PAI-2-levels in blood-samples collected preconceptionally and at 12-16 weeks in their next pregnancy...
2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27600972/leucocyte-expression-of-genes-implicated-in-the-plasminogen-activation-cascade-is-modulated-by-yoghurt-peptides
#19
COMPARATIVE STUDY
Georgios Theodorou, Ioannis Politis
The urokinase-plasminogen activator (u-PA), its receptor (u-PAR) and the inhibitors of u-PA (PAI-1 and PAI-2) provide a multi-molecular system in leucocytes that exerts pleiotropic functions influencing the development of inflammatory and immune responses. The objective of the present study was to examine the ability of water soluble extracts (WSE) obtained from traditional Greek yoghurt made from bovine or ovine milk to modulate the expression of u-PA, u-PAR, PAI-1 and PAI-2 in ovine monocytes and neutrophils...
August 2016: Journal of Dairy Research
https://www.readbyqxmd.com/read/27598010/fibrinolysis-parameters-in-sudanese-women-with-severe-preeclampsia
#20
Husham O Elzein, Abdel Rahim M Muddathir, Mohammed Rida, Duria A Rayis, Elhassan M Elhassan, Ishag Adam
BACKGROUND: Although preeclampsia remains a major cause of maternal and fetal morbidity and mortality, its pathogenesis is not fully understood. Coagulation and fibrinolysis changes were suggested to have a role in the pathogenesis of preeclampsia. OBJECTIVES: A case-control study was conducted in Medani Hospital, Sudan, to investigate thrombin-activatable fibrinolysis inhibitor (TAFI) and plasminogen-activated inhibitor (PAI) in women with severe preeclampsia. Obstetrics and medical history was gathered using questionnaire...
November 2016: Hypertension in Pregnancy
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