Yao-Tsung Tsai, Chih-Yi Li, Yen-Hua Huang, Te-Sheng Chang, Chung-Yen Lin, Chia-Hsien Chuang, Chih-Yang Wang, Gangga Anuraga, Tzu-Hao Chang, Tsung-Chieh Shih, Zu-Yau Lin, Yuh-Ling Chen, Ivy Chung, Kuen-Haur Lee, Che-Chang Chang, Shian-Ying Sung, Kai-Huei Yang, Wan-Lin Tsui, Chee-Voon Yap, Ming-Heng Wu
Most cases of hepatocellular carcinoma (HCC) arise with the fibrotic microenvironment where hepatic stellate cells (HSCs) and carcinoma-associated fibroblasts (CAFs) are critical components in HCC progression. Therefore, CAF normalization could be a feasible therapy for HCC. Galectin-1 (Gal-1), a β-galactoside-binding lectin, is critical for HSC activation and liver fibrosis. However, few studies has evaluated the pathological role of Gal-1 in HCC stroma and its role in hepatic CAF is unclear. Here we showed that Gal-1 mainly expressed in HCC stroma, but not cancer cells...
April 22, 2022: Oncogene