Hui Yuan, Entao Liu, Guojin Zhang, Chaoquan Lai, Qing Zhang, Yuxiang Shang, Zhen Cheng, Lei Jiang
PURPOSE: To identify the biodistribution and diagnostic performance of a novel fibroblast activation protein (FAP) targeted positron emission tomography (PET) tracer, [68 Ga]Ga-DOTA-GPFAPI-04, in patients with solid tumors in a head-to-head comparison with [18 F]F-FDG. METHODS: Twenty-six patients histologically proven with cancers of nasopharyngeal (n = 5), esophagus (n = 5), gastro-esophagus (n = 1), stomach (n = 7), liver (n = 3), and colorectum (n = 5) were recruited for [68 Ga]Ga-DOTA-GPFAPI-04 and [18 F]F-FDG PET/CT scans on consecutive days...
May 10, 2024: European Journal of Nuclear Medicine and Molecular Imaging