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https://www.readbyqxmd.com/read/28213991/the-value-of-workforce-data-in-shaping-nursing-workforce-policy-a-case-study-from-north-carolina
#1
Erin P Fraher
BACKGROUND: In 2015, the Institute of Medicine's Committee for Assessing Progress on Implementing the Future of Nursing recommendations noted that little progress has been made in building the data infrastructure needed to support nursing workforce policy. PURPOSE: This article outlines a case study from North Carolina to demonstrate the value of collecting, analyzing, and disseminating state-level workforce data. METHODS: Data were derived from licensure renewal information gathered by the North Carolina Board of Nursing and housed at the North Carolina Health Professions Data System at the University of North Carolina at Chapel Hill...
November 1, 2016: Nursing Outlook
https://www.readbyqxmd.com/read/28213175/quantitative-analysis-of-mycosporine-like-amino-acids-in-marine-algae-by-capillary-electrophoresis-with-diode-array-detection
#2
Anja Hartmann, Adele Murauer, Markus Ganzera
Marine species have evolved a variety of physical or chemical strategies to diminish damage from elevated environmental ultraviolet radiation. Mycosporine-like amino acids, a group of widely distributed small water soluble compounds, are biologically relevant because of their photo-protective potential. In addition, presumed antioxidant and skin protective strategies raise the interest for possible medicinal and cosmetic applications. In this study the first CE method for the quantification of mycosporine-like amino acids in marine species is presented...
February 4, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28212968/-what-goes-around-comes-around-lessons-learned-from-economic-evaluations-of-personalized-medicine-applied-to-digital-medicine
#3
Kathryn A Phillips, Michael P Douglas, Julia R Trosman, Deborah A Marshall
BACKGROUND: The growth of "big data" and the emphasis on patient-centered health care have led to the increasing use of two key technologies: personalized medicine and digital medicine. For these technologies to move into mainstream health care and be reimbursed by insurers, it will be essential to have evidence that their benefits provide reasonable value relative to their costs. These technologies, however, have complex characteristics that present challenges to the assessment of their economic value...
January 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28212966/estimating-preferences-for-complex-health-technologies-lessons-learned-and-implications-for-personalized-medicine
#4
Deborah A Marshall, Juan Marcos Gonzalez, Karen V MacDonald, F Reed Johnson
We examine key study design challenges of using stated-preference methods to estimate the value of whole-genome sequencing (WGS) as a specific example of genomic testing. Assessing the value of WGS is complex because WGS provides multiple findings, some of which can be incidental in nature and unrelated to the specific health concerns that motivated the test. In addition, WGS results can include actionable findings (variants considered to be clinically useful and can be acted on), findings for which evidence for best clinical action is not available (variants considered clinically valid but do not meet as high of a standard for clinical usefulness), and findings of unknown significance...
January 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28212965/assessing-the-value-and-implications-of-personalized-precision-medicine-and-the-lessons-learned-for-emerging-technologies-an-introduction
#5
EDITORIAL
Kathryn A Phillips
No abstract text is available yet for this article.
January 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28212951/priority-to-end-of-life-treatments-views-of-the-public-in-the-netherlands
#6
Sofie Wouters, Job van Exel, Rachel Baker, Werner B F Brouwer
OBJECTIVES: Recent debates in the Netherlands on health care priority setting have focused on the relative value of gains generated by life-extending medicines for people with a terminal illness, mostly new cancer drugs. These treatments are generally expensive, provide relatively small health gains, and therefore usually do not meet common cost per QALY thresholds. Nevertheless, these drugs may be provided under the assumption that there is public support for making a special case for treatments for people with a terminal illness...
January 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28212308/antimicrobial-treatment-of-polymeric-medical-devices-by-silver-nanomaterials-and-related-technology
#7
REVIEW
Markéta Polívková, Tomáš Hubáček, Marek Staszek, Václav Švorčík, Jakub Siegel
Antimicrobial biocompatible polymers form a group of highly desirable materials in medicinal technology that exhibit interesting thermal and mechanical properties, and high chemical resistance. There are numerous types of polymers with antimicrobial activity or antimicrobial properties conferred through their proper modification. In this review, we focus on the second type of polymers, especially those whose antimicrobial activity is conferred by nanotechnology. Nanotechnology processing is a developing area that exploits the antibacterial effects of broad-scale compounds, both organic and inorganic, to form value-added medical devices...
February 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28211325/impact-of-concentration-and-species-of-sulfamethoxazole-and-ofloxacin-on-their-adsorption-kinetics-on-sediments
#8
Peng Wang, Di Zhang, Huang Zhang, Hao Li, Saikat Ghosh, Bo Pan
Antibiotics are used widely in human and veterinary medicine and are ubiquitous in environmental matrices worldwide. The influence of the concentration of antibiotics on adsorption kinetics is still unclear. This study used sulfamethoxazole (SMX) and ofloxacin (OFL) as adsorbates to investigate the adsorption kinetics on sediment affected by varying concentrations of antibiotics adsorbable species. At the experimental pH values, the major adsorbed species of SMX and OFL on sediment were SMX(0) and OFL(+) by hydrophobic interaction and electrostatic attraction, respectively...
February 9, 2017: Chemosphere
https://www.readbyqxmd.com/read/28209076/an-ethnopharmacological-study-of-aromatic-uyghur-medicinal-plants-in-xinjiang-china
#9
Lu Zhao, Shuge Tian, E Wen, Halmuart Upur
CONTEXT: An ethnobotanical survey was completed in a remote village and surrounding country of Xinjiang, where most Uyghur medicinal plants could be collected. This work clarifies and increases ethnobotanical data. OBJECTIVES: We surveyed and organized aromatic medicinal plants that are commonly used in clinical settings to provide a significant reference for studying new medical activities. MATERIALS AND METHODS: In the survey, informants who have traditional knowledge on aromatic Uyghur medicinal plants were interviewed between March 2014 and September 2014...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28207992/inhibitory-activities-of-n-butanol-fraction-from-butea-monosperma-lam-taub-bark-against-free-radicals-genotoxins-and-cancer-cells
#10
Varinder Kaur, Manish Kumar, Paramjeet Kaur, Sandeep Kaur, Satwinderjeet Kaur
The present study was undertaken to investigate antioxidant, antigenotoxic and antiproliferative activity of n-butanol fraction (Bmbu) from bark of medicinal plant Butea monosperma. Antioxidant potency of Bmbu was examined by various in vitro assays. It was also investigated for antigenotoxic activity using E. coli. PQ37 employing SOS chromotest. Further, cytotoxic and apoptosis inducing activity of Bmbu was evaluated in MCF-7 breast cancer cells. Bmbu showed potent free radical scavenging ability in ABTS assay (IC50 56...
February 16, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28207861/in-vitro-anti-herpes-simplex-virus-2-activity-of-salvia-desoleana-atzei-v-picci-essential-oil
#11
Valeria Cagno, Barbara Sgorbini, Cinzia Sanna, Cecilia Cagliero, Mauro Ballero, Andrea Civra, Manuela Donalisio, Carlo Bicchi, David Lembo, Patrizia Rubiolo
Salvia desoleana Atzei & V. Picci is an indigenous species in Sardinia island used in folk medicine to treat menstrual, digestive and central nervous system diseases. Nowadays, it is widely cultivated for the pleasant smell of its essential oil (EO), whose antimicrobial and antifungal activities have already been screened. This study evaluated the in vitro anti-Herpes Simplex Virus-2 (HSV-2) activity of S. desoleana EO, fractions and main components: linalyl acetate, alpha terpinyl acetate, and germacrene D...
2017: PloS One
https://www.readbyqxmd.com/read/28207163/prognostic-value-and-development-of-a-scoring-system-in-horses-with-systemic-inflammatory-response-syndrome
#12
M-F Roy, G P S Kwong, J Lambert, S Massie, S Lockhart
BACKGROUND: Despite its widespread use in equine medicine, the clinical value of the systemic inflammatory response syndrome (SIRS) concept in horses remains unknown. OBJECTIVES: To study the prognostic value of measures of SIRS in horses and identify the best model of severe SIRS to predict outcome. ANIMALS: A total of 479 consecutive adult horse emergency admissions to a private primary referral practice. METHODS: Prospective observational study...
February 16, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28206828/validity-of-the-timed-25-foot-walk-as-an-ambulatory-performance-outcome-measure-for-multiple-sclerosis
#13
Robert W Motl, Jeffrey A Cohen, Ralph Benedict, Glenn Phillips, Nicholas LaRocca, Lynn D Hudson, Richard Rudick
The Multiple Sclerosis Outcome Assessments Consortium (MSOAC) includes representatives from advocacy organizations, Food and Drug Administration (FDA), European Medicines Agency (EMA), National Institute of Neurological Disorders and Stroke (NINDS), academic institutions, and industry partners along with persons living with multiple sclerosis (MS). One of the MSOAC goals is acceptance and qualification by regulators of performance outcomes that are highly reliable and valid, practical, cost-effective, and meaningful in MS...
February 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28205506/prospective-surveillance-of-antiviral-resistance-in-hospitalized-infants-less-than-12-months-of-age-with-a-h3n2-influenza-infection-and-treated-with-oseltamivir
#14
Barbara Rath, Xi Chen, Vera Spies, Susann Muehlhans, Patrick Obermeier, Franziska Tief, Lea Seeber, Katharina Karsch, Jeanette Milde, Heino Skopnik, Brunhilde Schweiger, Susanne C Duwe
BACKGROUND: Infants exhibit elevated influenza virus loads and prolonged viral shedding, which may increase the risk for resistance development, especially in cases of suboptimal exposure to antiviral therapy. METHODS: We performed a prospective surveillance of hospitalized infants undergoing oseltamivir therapy during the 2008-2009 and 2011-2012 influenza seasons at two paediatric hospitals in Germany. A total of 37 infants less than one year of age with laboratory confirmed influenza A(H3N2) infection received oseltamivir as per physician's order for 5 days (2008-2009 season: 2mg/kg BID; 2011-2012 season: 2...
February 16, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28203619/variation-in-the-response-of-eastern-and-southern-africa-provenances-of-faidherbia-albida-delile-a-chev-seedlings-to-water-supply-a-greenhouse-experiment
#15
Grace Koech, Daniel Ofori, Anne W T Muigai, Jonathan Muriuki, Parveen Anjarwalla, Jan De Leeuw, Jeremias G Mowo
Rural communities value Faidherbia albida in farming systems and pastoralism. Faidherbia albida provides products such as medicine, fodder, fuel, wood, food and services such as shade, soil fertility and nutrient cycling. Excessive browsing by animals, branch lopping and pod harvesting, have critically reduced the natural regeneration in some areas which exposes it to challenges due to dependence upon natural regeneration. The objective of this research was to evaluate response of Faidherbia albida provenances from eastern (Taveta Wangingombe) and southern Africa (Lupaso, Kuiseb Manapools) to different watering regimes to aid in selection of provenances for domestication...
October 2016: Global Ecology and Conservation
https://www.readbyqxmd.com/read/28203449/a-cost-utility-analysis-of-different-antiviral-medicine-regimens-in-patients-with-chronic-hepatitis-c-virus-genotype-1-infection
#16
Seyed Moayed Alavian, Shekoufeh Nikfar, Abbas Kebriaeezadeh, Farhad Lotfi, Ehsan Sanati, Mohsen Rezaei Hemami, Khosro Keshavarz
BACKGROUND: Despite the introduction of new drug regimens with high effectiveness for the hepatitis C virus (HCV) patients, especially in HCV genotype 1, no cost-effectiveness study on the selection of the superior drug strategy in Iran has been conducted yet. OBJECTIVES: This study is aimed to assess the cost-effectiveness of the three drug regimens of pegylated interferon and ribavirin (PR), sofosbuvir (SOF) + PR and ledipasvir and sofosbuvir (LDV/SOF) in patients with HCV genotype 1 in Iran in the year 2014...
November 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28203259/insights-into-the-action-mechanisms-of-traditional-chinese-medicine-in-osteoarthritis
#17
REVIEW
Linfu Li, Haiqing Liu, Weimei Shi, Hai Liu, Jianqiong Yang, Daohua Xu, Hao Huang, Longhuo Wu
Osteoarthritis (OA) is a chronic degenerative joint disease characterized by articular cartilage destruction, synovial inflammation, and osteophyte formation. No effective treatments are available. The current pharmacological medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) and analgesics, accompanied by possible adverse effects, might ameliorate OA symptoms. But they do not arrest the progression of OA. Traditional Chinese medicine (TCM) provides medical value by modification of disease and symptoms in OA...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28201965/preparation-and-characterization-of-silymarin-synchronized-and-sustained-release-dropping-pill
#18
Zhi-Hong Liu, Xue-Jing Li, Ai-Wen Huang, Jing Zhang, Hong-Tao Song
PURPOSE: This study aimed to develop a synchronized and sustained-release silymarin dropping pill, and to evaluate its pharmacokinetic characteristics. METHODS: Polyoxyethylene stearate, glyceryl monostearate, and stearic acid were used to prepare the dropping pills. X-ray powder diffraction, differential scanning calorimetry, and release were used to evaluate its physicochemical properties. The plasma concentration of silybin in beagle dogs after oral administration of silymarin dropping pills and silymarin capsule was determined by RP-HPLC...
February 13, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28201852/the-probability-of-probability-and-research-truths
#19
Daniel M Fatovich, Michael Phillips
The foundation of much medical research rests on the statistical significance of the P-value, but we have fallen prey to the seductive certainty of significance. Other scientific disciplines work to a different standard. This may partly explain why medical reversal is an increasing phenomenon, whereby new studies (based on the 0.05 standard) overturn previous significant findings. This has generated a crisis in the rigour of evidence-based medicine, as many people erroneously believe that a P < 0.05 means the treatment effect is clinically important...
February 15, 2017: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/28199921/pilot-scale-bioconversion-of-rice-and-sunflower-agro-residues-into-medicinal-mushrooms-and-laccase-enzymes-through-solid-state-fermentation-with-ganoderma-lucidum
#20
P D Postemsky, M A Bidegain, R González-Matute, N D Figlas, M A Cubitto
Solid-state fermentation was evaluated at the pilot-scale for the bioconversion and valorization of rice husks and straw (RSH), or sunflower seed hulls (SSH), into medicinal mushrooms and crude extracts, with laccase activity. The average mushroom yield was 56kg dry weight per ton of agro-residues. Laccase activity in crude aqueous extracts showed its maximum value of 10,927Ukg(-1) in RSH (day 10, Exudate phase) and 16,442Ukg(-1) in SSH (day 5, Full colonization phase), the activity at the Residual substrate phase being 511Ukg(-1) in RSH and 803Ukg(-1) in SSH, respectively...
February 2, 2017: Bioresource Technology
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