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https://www.readbyqxmd.com/read/29122348/associations-of-urinary-phthalate-metabolites-with-residential-characteristics-lifestyles-and-dietary-habits-among-young-children-in-shanghai-china
#1
Chenxi Liao, Wei Liu, Jialing Zhang, Wenming Shi, Xueying Wang, Jiao Cai, Zhijun Zou, Rongchun Lu, Chanjuan Sun, Heng Wang, Chen Huang, Zhuohui Zhao
Exposure to household phthalates has been reported to have adverse effects on children's health. In this paper, we used phthalate metabolites in the first morning urine as indicators of household phthalate exposures and examined their associations with residential characteristics, lifestyles and dietary habits among young children. During 2013-2014, we collected morning urines from children aged 5-10years in Shanghai, China and obtained the related information about analyzed factors in this study by questionnaires...
November 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29120934/predictors-of-program-completion-and-nclex-rn-success-in-an-associate-degree-nursing-program
#2
Nicole Robert
Unsuccessful nursing students have a great impact on nursing programs. The purpose of this study was to determine the relationships among preadmission HESI A2 (Health Education Systems, Incorporated Admission Assessment) score, science and math course grades, program completion, and NCLEX-RN success in an associate degree nursing program using a retrospective, correlational research design. A statistically significant relationship was found between preadmission examination scores and successful NCLEX-RN passage on first attempt...
November 9, 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/29071365/dispersive-multi-walled-carbon-nanotubes-extraction-of-benzenesulfonamides-benzotriazoles-and-benzothiazoles-from-environmental-waters-followed-by-microwave-desorption-and-hplc-hesi-ms-ms
#3
Andrea Speltini, Federica Maraschi, Michela Sturini, Matteo Contini, Antonella Profumo
This work shows a novel analytical method for the simultaneous extraction of environmental emerging contaminants as benzenesulfonamides (BSAs), benzotriazoles (BTRs), and benzothiazoles (BTs) from water samples. Pristine multi-walled carbon nanotubes (MWCNTs), not yet tested for such analytes, are here employed as the sorbent phase for dispersive solid-phase extraction (d-SPE) followed by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry (HPLC-HESI-MS/MS). Quantitative sorption is gained by treating 50 mL sample with 100 mg MWCNTs (2 g L(-1)) in 10 min contact, both in tap and raw river water...
October 25, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28992566/quantification-of-xanthine-and-uric-acid-related-compounds-in-urine-using-a-dilute-and-shoot-technique-coupling-ultra-high-performance-liquid-chromatography-and-high-resolution-orbitrap-mass-spectrometry
#4
Adrian Rodriguez, Rosa Maria Gomila, Gabriel Martorell, Antonia Costa-Bauza, Felix Grases
Quantitative analysis of relevant metabolites in biofluids such as urine is often a tedious procedure, since it usually requires extraction, purification or preconcentration. For instance, in the analysis of methylxanthines in urine, a solid-phase extraction is often required. In the current work, a rapid and highly sensitive "dilute-and-shoot" method combining ultra-high-performance liquid chromatography and high-resolution mass spectrometry (UHPLC/HRMS) was validated for urinary determination of twelve analytes: uric acid, hypoxanthine, xanthine, 1-methyluric acid, 1,3-dimethyluric acid, 1-methylxanthine, 3-methylxanthine, 7-methylxanthine, theophylline, theobromine, paraxanthine and caffeine...
November 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28968543/correlates-of-school-dropout-and-absenteeism-among-adolescent-girls-from-marginalized-community-in-north-karnataka-south-india
#5
Ravi Prakash, Tara Beattie, Prakash Javalkar, Parinita Bhattacharjee, Satyanarayana Ramanaik, Raghavendra Thalinja, Srikanta Murthy, Calum Davey, James Blanchard, Charlotte Watts, Martine Collumbien, Stephen Moses, Lori Heise, Shajy Isac
Secondary education among lower caste adolescent girls living in rural Karnataka, South India, is characterized by high rates of school drop-out and absenteeism. A cross-sectional baseline survey (N=2275) was conducted in 2014 as part of a cluster-randomized control trial among adolescent girls (13-14 year) and their families from marginalized communities in two districts of north Karnataka. Bivariate and multivariate logistic regression models were used. Overall, 8.7% girls reported secondary school dropout and 8...
September 29, 2017: Journal of Adolescence
https://www.readbyqxmd.com/read/28877433/detection-of-chemical-warfare-agent-related-phenylarsenic-compounds-in-marine-biota-samples-by-lc-hesi-ms-ms
#6
Hanna Niemikoski, Martin Söderström, Paula Vanninen
A new method has been developed to determine oxidation products of three chemical warfare agent (CWA) related phenylarsenic compounds from marine biota samples by a liquid chromatography-heated electrospray ionization/tandem mass spectrometry (LC-HESI/MS/MS). The target chemicals were oxidation products of Adamsite (DM[ox]), Clark I (DPA[ox]), and triphenylarsine (TPA[ox]). Method was validated within the concentration range of 1-5, 0.2-5, and 0.2-5 ng/g for DM[ox], DPA[ox], and TPA[ox], respectively. The method was linear, precise and accurate...
October 17, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28876440/factors-associated-with-first-time-nclex-rn-success-a-descriptive-research-study
#7
Tanya Johnson, Bonnie Sanderson, Chih-Hsuan Wang, Francine Parker
BACKGROUND: The purpose of this study was to identify variables associated with scores achieved on the Health Education Systems, Inc. (HESI) exit examination and successful first-time NCLEX-RN(®) pass rates. METHOD: A retrospective descriptive study examined the administrative data of 211 baccalaureate nursing students. RESULTS: Students who completed the program in sequence and scored higher in certain HESI course examinations were more likely to have a better performance on the HESI exit examination...
September 1, 2017: Journal of Nursing Education
https://www.readbyqxmd.com/read/28820983/a-sensitive-method-for-the-separation-and-quantification-of-low-level-adenine-nucleotides-using-porous-graphitic-carbon-based-liquid-chromatography-and-tandem-mass-spectrometry
#8
Sonia Bustamante, Robert B Gilchrist, Dulama Richani
A liquid chromatography coupled to heated electrospray ionization/tandem mass spectrometry (LC-HESI-MS/MS) method was developed for the simultaneous quantitative analysis of low nanomolar level adenine nucleotides AMP, ADP, ATP, cyclic AMP (cAMP), and the nucleoside adenosine. For analyte retention and separation, reverse phase chromatography using porous graphitic carbon (PGC) was employed as it provided full resolution. The erratic chromatographic behaviour characteristic of PGC, including deterioration of analyte resolution and increased peak tailing (leading to decreased sensitivity), was mitigated by incorporating acidic equilibration within runs using a quaternary gradient...
September 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28802219/development-and-validation-of-a-high-performance-liquid-chromatography-tandem-mass-spectrometry-method-to-quantify-ly-354-740-in-rat-and-marmoset-plasma
#9
Fleur Gaudette, Adjia Hamadjida, Dominique Bédard, Stephen G Nuara, Francis Beaudry, Philippe Huot
LY-354,740 (eglumegad) is a selective and potent agonist of the metabotropic glutamate group II receptors (mGluR2,3) that has already entered clinical trials as a potential anti-psychotic agent and therefore has well-documented pharmacokinetic (PK), safety and tolerability profiles in human. Whereas its development as an anti-psychotic agent has not been pursued, LY-354,740 may have potential in other neuroscience-related fields, notably anxiety and neuro-protection. The common marmoset is a small primate that has long been used in neuroscience...
September 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28742650/reliable-and-easy-to-use-liquid-chromatography-tandem-mass-spectrometry-method-for-simultaneous-analysis-of-fluconazole-isavuconazole-itraconazole-hydroxy-itraconazole-posaconazole-and-voriconazole-in-human-plasma-and-serum
#10
Carsten Müller, David Gehlen, Cornelia Blaich, Domenik Prozeller, Blasius Liss, Thomas Streichert, Martin H J Wiesen
BACKGROUND: A fast and easy-to-use liquid chromatography-tandem mass spectrometry method for the determination and quantification of 6 triazoles [fluconazole (FLZ), isavuconazole (ISZ), itraconazole (ITZ), hydroxy-itraconazole (OH-ITZ), posaconazole (PSZ), and voriconazole (VRZ)] in human plasma and serum was developed and validated for therapeutic drug monitoring. METHODS: Sample preparation was based on protein precipitation with acetonitrile and subsequent centrifugation...
October 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28658524/determination-of-testosterone-esters-in-the-hair-of-male-greyhound-dogs-using-liquid-chromatography-high-resolution-mass-spectrometry
#11
Jayasree Leela Devi, Paul Zahra, John H Vine, Ted Whittem
The doping of greyhound dogs with testosterone is done in an attempt to improve their athletic performance, but such doping cannot easily be confirmed especially in male dogs owing to the natural presence of endogenous testosterone. As testosterone is usually administered as its esters their direct detection in hair would provide confirmatory evidence of the administration of a pharmaceutical product. This paper demonstrates that the use of a liquid chromatography-high resolution mass spectrometry method with heated electrospray ionisation (HESI) combined with the use of amino SPE cartridges for sample clean up, is suitable for the sensitive determination of propionate, phenyl propionate, isocaproate, decanoate and enanthate esters of testosterone in greyhound hair...
June 28, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28655687/the-balkan-endemic-plant-nepeta-rtanjensis-lamiaceae-phenolic-composition-antioxidant-activity-and-antigenotoxic-effects-on-human-lymphocytes-treated-with-triiodothyronine-in-vitro
#12
Jasna Bosnjak-Neumuller, Milena Radakovic, Ninoslav Djelic, Branka Vukovic-Gacic, Zora Dajic Stevanovic, Stoimir Kolarevic, Danijela Misic, Milan Stankovic, Jelena Knezevic-Vukcevicc, Biljana Spremo-Potparevic, Zoran Stanimirovic
The success of antioxidant therapy in hyperthyroidism implies that disease is mediated by oxidative stress, which is known as one of the causing agents of ageing, degenerative diseases, and cancer. The main objective of our study was to determine possible protective effects of methanolic extract of N. rtanjensis in triiodothyronine (T3)-induced DNA breaks of human lymphocytes under in vitro conditions, based upon plant antioxidant capacity related to its phytochemical profile, mainly its polyphenolic complex...
May 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28650332/nepeta-rtanjensis-lamiaceae-a-plant-endemic-to-the-balkans-phenolic-composition-antioxidant-activity-and-in-vitro-antigenotoxic-effects-in-triiodothyronine-induced-dna-damage-in-human-lymphocytes
#13
Jasna Bošnjak-Neumüller, Milena Radaković, Ninoslav Djelić, Branka Vuković-Gačić, Zora Dajić Stevanović, Stoimir Kolarević, Danijela Mišić, Milan Stanković, Jelena Knežević-Vukčević, Biljana Spremo-Potparević, Zoran Stanimirović
The success of antioxidant therapy in hyperthyroidism implies that disease is mediated by oxidative stress, which is known as one of the causing agents of ageing, degenerative diseases, and cancer. The main objective of our study was to determine possible protective effects of methanolic extract of N. rtanjensis in triiodothyronine (T3)-induced DNA breaks of human lymphocytes under in vitro conditions, based upon plant antioxidant capacity related to its phytochemical profile, mainly its polyphenolic complex...
March 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28628072/retention-of-content-utilizing-a-flipped-classroom-approach
#14
Bobbi Shatto, Kristine LʼEcuyer, Jerod Quinn
The flipped classroom experience promotes retention and accountability for learning. The authors report their evaluation of a flipped classroom for accelerated second-degree nursing students during their primary medical-surgical nursing course. Standardized HESI® scores were compared between a group of students who experienced the flipped classroom and a previous group who had traditional teaching methods. Short- and long-term retention was measured using standardized exams 3 months and 12 months following the course...
July 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/28585983/exploring-the-correlation-between-nontraditional-variables-and-student-success-a-longitudinal-study
#15
Haley Perkins Strickland, Michelle Haney Cheshire
BACKGROUND: The purpose of this project was to determine whether a correlation exists between the traditional admission criteria of grade point averages with the potential admission criteria of emotional intelligence (EI) scores or critical thinking (CT) scores to predict upper division student outcomes. METHOD: A quantitative, longitudinal design was selected to examine the identified variables to predict undergraduate student success. The recruiting sample included a convenience sample drawn from 112 junior-level undergraduate nursing students beginning their first of a five-semester nursing program...
June 1, 2017: Journal of Nursing Education
https://www.readbyqxmd.com/read/28577816/academic-and-demographic-predictors-of-nclex-rn-pass-rates-in-first-and-second-degree-accelerated-bsn-programs
#16
Mahmoud A Kaddoura, Elizabeth P Flint, Olga Van Dyke, Qing Yang, Li-Chi Chiang
Relatively few studies have addressed predictors of first-attempt outcomes (pass-fail) on the National Council Licensure Examination-Registered Nurses (NCLEX-RN) for accelerated BSN programs. The purpose of this study was to compare potential predictors of NCLEX outcomes in graduates of first-degree accelerated (FDA; n=62) and second-degree accelerated (SDA; n=173) BSN programs sharing a common nursing curriculum. In this retrospective study, bivariate analyses and multiple logistic regression assessed significance of selected demographic and academic characteristics as predictors of NCLEX-RN outcomes...
May 2017: Journal of Professional Nursing: Official Journal of the American Association of Colleges of Nursing
https://www.readbyqxmd.com/read/28434968/cardiac-contractility-correction-strategies-applied-to-telemetry-data-from-a-hesi-sponsored-consortium
#17
Emmanuel Boulay, Michael K Pugsley, Vincent Jacquemet, Alain Vinet, Michael V Accardi, Maxim Soloviev, Eric Troncy, Jennifer M Doyle, Jennifer Beck Pierson, Simon Authier
INTRODUCTION: QT has a long history of heart rate (HR) correction but limited investigations have been undertaken to assess the impact of cardiovascular parameters on left ventricular (LV) contractility in drug safety testing. Cardiac contractility is affected by preload (Cyon-Frank-Starling law), afterload (Anrep effect) and HR (Bowditch effect). We evaluated multi-parameter correction methods to help with dP/dtmax interpretation. METHODOLOGY: Modeling was undertaken using data from dogs in single or double 4×4 Latin square studies...
April 21, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/28364517/an-integrative-review-on-standardized-exams-as-a-predictive-admission-criterion-for-rn-programs
#18
Julie E Twidwell, Kathie Records
Nursing programs reject qualified applicants due to limited clinical placements and faculty. By admitting the strongest candidates, schools of nursing will reduce attrition rates, increase NCLEX-RN pass rates, and speed the entry into practice of well-prepared nurses to help stem the nursing shortage. This integrative review identified the standardized admission exams most predictive of student success. Included were articles published between 2005 and 2016 that focused on admission criteria, RN programs, specific exams (e...
April 1, 2017: International Journal of Nursing Education Scholarship
https://www.readbyqxmd.com/read/28314391/trace-determination-of-perfluorooctane-sulfonate-and-perfluorooctanoic-acid-in-environmental-samples-surface-water-wastewater-biota-sediments-and-sewage-sludge-using-liquid-chromatography-orbitrap-mass-spectrometry
#19
D Zacs, V Bartkevics
An analytical method was established and validated for the analysis of the most frequently monitored representatives among the group of perfluorinated compounds (PFAS), namely, perfluorooctanoic acid (PFOA) and prefluorooctane sulfonate (PFOS) in environmental samples (surface water, wastewater, sediments, sewage sludge, and biota). High performance liquid chromatography (HPLC) coupled to Orbitrap mass spectrometry (Orbitrap-MS) employing a heated electrospray ionization (HESI) interface operated in negative mode was used for the quantitative determination of these contaminants...
November 18, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28266262/using-exposure-bands-for-rapid-decision-making-in-the-risk21-tiered-exposure-assessment
#20
REVIEW
M Dellarco, R Zaleski, B J Gaborek, H Qian, C A Bellin, P Egeghy, N Heard, O Jolliet, D R Lander, N Sunger, K S Stylianou, J Y Tanir
The ILSI Health and Environmental Sciences Institute (HESI) Risk Assessment in the Twenty-first Century (RISK21) project was initiated to address and catalyze improvements in human health risk assessment. RISK21 is a problem formulation-based conceptual roadmap and risk matrix visualization tool, facilitating transparent evaluation of both hazard and exposure components. The RISK21 roadmap is exposure-driven, that is, exposure is used as the second step (after problem formulation) to define and focus the assessment...
April 2017: Critical Reviews in Toxicology
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