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Agnès Daudignon, Benoît Quilichini, Geneviève Ameye, Hélène Poirel, Christian Bastard, Christine Terré
Cytogenetics of multiple myeloma has evolved in recent years by the emergence of Interphasic fluorescence in situ hybridization (FISH) performed on sorted plasma cells detecting abnormalities independently of a proliferative and infiltrative index. Cytogenetic analysis plays a major part in the risk stratification of myeloma diagnosis due to prognostic impact of various cytogenetic abnormalities as well as to the association between emerging therapeutic approaches in MM. Thus, practice guidelines now recommend interphasic FISH or alternative molecular technics as the initial analysis for multiple myeloma...
October 1, 2016: Annales de Biologie Clinique
Luis Felipe Casado, Amparo Burgos, Eva González-Haba, Javier Loscertales, Tania Krivasi, Javier Orofino, Carlos Rubio-Terres, Darío Rubio-Rodríguez
OBJECTIVE: To evaluate the cost-effectiveness of obinutuzumab in combination with chlorambucil (GClb) versus rituximab plus chlorambucil (RClb) in the treatment of adults with previously untreated chronic lymphocytic leukemia (CLL) and with comorbidities that make them unsuitable for full-dose fludarabine-based therapy, from the perspective of the Spanish National Health System. METHODS: A Markov model was developed with three mutually exclusive health states: progression-free survival (with or without treatment), progression, and death...
2016: ClinicoEconomics and Outcomes Research: CEOR
O Nibourel, S Guihard, C Roumier, N Pottier, C Terre, A Paquet, P Peyrouze, S Geffroy, S Quentin, A Alberdi, R B Abdelali, A Renneville, C Demay, K Celli-Lebras, P Barbry, B Quesnel, S Castaigne, H Dombret, J Soulier, C Preudhomme, M H Cheok
Recent advances in genomic technologies have revolutionized acute myeloid leukemia (AML) understanding by identifying potential novel actionable genomic alterations. Consequently, current risk stratification at diagnosis not only relies on cytogenetics but also on the inclusion of several of these abnormalities. Despite this progress, AML remains a heterogeneous and complex malignancy with variable response to current therapy. Although copy number alterations (CNA) are accepted prognostic markers in cancers, large-scale genomic studies aiming at identifying specific prognostic CNA-based markers in AML are still lacking...
September 30, 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Martina Cappelletti, Daniele Ghezzi, Davide Zannoni, Bruno Capaccioni, Stefano Fedi
"Terre Calde di Medolla" (TCM) (literally, "Hot Lands of Medolla") refers to a farming area in Italy with anomalously high temperatures and diffuse emissions of biogenic CO2, which has been linked to CH4 oxidation processes from a depth of 0.7 m to the surface. We herein assessed the composition of the total bacterial community and diversity of methane-oxidizing bacteria (MOB) in soil samples collected at a depth at which the peak temperature was detected (0.6 m). Cultivation-independent methods were used, such as: i) a clone library analysis of the 16S rRNA gene and pmoA (coding for the α-subunit of the particulate methane monooxygenase) gene, and ii) Terminal Restriction Fragment Length Polymorphism (T-RFLP) fingerprinting...
September 17, 2016: Microbes and Environments
Tina M Kruger, Sarah Gilland, Jacquelyn B Frank, Bridget C Murphy, Courtney English, Jana Meade, Kaylee Morrow, Evan Rush
In May 2014, a short-term study-abroad experience was conducted in Finland through a course offered at Indiana State University (ISU). Students and faculty from ISU and Eastern Illinois University participated in the experience, which was created to facilitate a cross-cultural comparison of long-term-care settings in the United States and Finland. With its outstanding system of caring for the health and social needs of its aging populace, Finland is a logical model to examine when considering ways to improve the quality of life for older adults who require care in the United States ...
September 16, 2016: Gerontology & Geriatrics Education
Isabelle Luquet, Audrey Bidet, Wendy Cuccuini, Marina Lafage-Pochitaloff, Marie-Joëlle Mozziconacci, Christine Terré
The karyotype is critical for the evaluation of acute myeloid leukemia (AML) at diagnosis. Cytogenetic abnormalities detected in AML are one of the most powerful independent prognostic factors. It impacts on the choice of treatment in clinical trials. All chromosomes can be targeted, common chromosomal abnormalities are recurrent and may be associated with a cytological well-defined type. In 40% of the cases, the karyotype is normal and must be associated with molecular biology studies that can refine the prognosis...
October 1, 2016: Annales de Biologie Clinique
Jordan Levine, Michael Muthukrishna, Kai Chan, Terre Satterfield
In this paper, we take a first step towards better integrating social concerns into empirical ecosystem services (ES) work. We do this by adapting cognitive anthropological techniques to study the Clayoquot Sound social-ecological system, on Canada's Pacific coast. There, we used freelisting and ranking exercises to elicit measures of locals' ES values, and preferred food species, analyzing the data with ANTHROPAC. We consider the results in light of an ongoing 'trophic cascade,' caused by the reintroduction and spread of sea otters (Enhydra lutris) along the island's coast...
July 13, 2016: Conservation Biology: the Journal of the Society for Conservation Biology
Christopher Cabib, Omar Ortega, Hatice Kumru, Ernest Palomeras, Natalia Vilardell, Daniel Alvarez-Berdugo, Desirée Muriana, Laia Rofes, Rosa Terré, Fermín Mearin, Pere Clavé
Oropharyngeal dysphagia (OD) is very prevalent among poststroke patients, causing severe complications but lacking specific neurorehabilitation treatment. This review covers advances in the pathophysiology, diagnosis, and physiologically based neurorehabilitation strategies for poststroke OD. The pathophysiology of oropharyngeal biomechanics can be assessed by videofluoroscopy, as delayed laryngeal vestibule closure is closely associated with aspiration. Stroke may affect afferent or efferent neuronal circuits participating in deglutition...
July 11, 2016: Annals of the New York Academy of Sciences
Oliver Lasry, Roy W Dudley, Rebecca Fuhrer, Jill Torrie, Robert Carlin, Judith Marcoux
BACKGROUND: Indigenous populations are disproportionately affected by traumatic brain injury. These populations rely on large jurisdiction surveillance efforts to inform their prevention strategies, which may not address their needs. We examined the incidence and determinants of traumatic brain injury in an indigenous population in the Terres-Cries-de-la-Baie-James health region of the province of Quebec and compared them with the incidence and determinants in 2 neighbouring health regions and in the province overall...
April 2016: CMAJ Open
François Meurgey
The genus Macrothemis consists of 40 Neotropical species (Garrison et al. 2006). Recently, a new species, Macrothemis meurgeyi from Guadeloupe (French West Indies), was described based on specimens from Habitation Deravin, Basse-Terre (Daigle 2007).
2016: Zootaxa
J G Hanly, A Sayani, S Doucette, S Iczkovitz, J A Ross Terres
OBJECTIVE: The treatment algorithm for new onset systemic lupus erythematosus (SLE) is less well defined than for other rheumatic diseases. We examined the treatment patterns in an inception cohort of SLE patients over the first three years of disease between 2000 and 2010. METHODS: Patients fulfilled the American College of Rheumatology classification criteria for SLE within 12 months of enrollment and completed three subsequent annual visits. Data collection included patient demographics, SLE manifestations, medications, SLE disease activity index-2K (SLEDAI-2K) and Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index...
June 30, 2016: Lupus
Corentin Bochaton, Renaud Boistel, Fabrice Casagrande, Sandrine Grouard, Salvador Bailon
Today, Diploglossine lizards (Anguidae) are common on the Greater Antillean Islands (West Indies), where they are represented by many endemic species. However these lizards are very rare on the Lesser Antillean Islands, where they are only represented by a single species, the Montserrat galliwasp (Diploglossus montisserrati). Here, we show that diploglossine lizards were present in the past on other Lesser Antillean islands, by reporting the discovery of Anguidae fossil remains in two Amerindian archaeological deposits and in a modern deposit...
2016: Scientific Reports
M Terré, M Devant, A Bach
We performed 3 studies to evaluate the effects of feed sensory and form preferences in young calves on performance and rumen fermentation dynamics. In experiment 1, starter feeds containing wheat and soybean meal; wheat and canola meal; and oats and soybean meal were evaluated in 63 calves (9±0.9 d old). In experiment 2, 37 crossbreed female calves were used from 4 to 45 d of age (weaning) in a cafeteria study consisting of 4 different presentations of the same starter feed: meal, pellet, pellet mixed with whole-cereal grains (WHG), and pellet mixed with steamed-rolled cereal grains (SRG)...
September 2016: Journal of Dairy Science
Mahdi Mohammadi, Mohammad Javad Zare, Hojjat Madadi, Jordi Sellarès, Jasmina Casals-Terré
Direct-current insulator-based dielectrophoresis (DC-iDEP) is a well-known technique that benefits from the electric field gradients generated by an array of insulating posts to separate or trap biological particles. The aim of this study is to provide a first geometrical relationship of the post array that independent of the particles and/or medium, maximizes the trapping. A novel figure of merit is proposed to maximize the particle trapping in the post array while minimizing the required voltage, with a similar footprint and channel thickness...
July 2016: Analytical and Bioanalytical Chemistry
B Terrés, L A Chizhova, F Libisch, J Peiro, D Jörger, S Engels, A Girschik, K Watanabe, T Taniguchi, S V Rotkin, J Burgdörfer, C Stampfer
Quantum point contacts are cornerstones of mesoscopic physics and central building blocks for quantum electronics. Although the Fermi wavelength in high-quality bulk graphene can be tuned up to hundreds of nanometres, the observation of quantum confinement of Dirac electrons in nanostructured graphene has proven surprisingly challenging. Here we show ballistic transport and quantized conductance of size-confined Dirac fermions in lithographically defined graphene constrictions. At high carrier densities, the observed conductance agrees excellently with the Landauer theory of ballistic transport without any adjustable parameter...
2016: Nature Communications
Christina C Hicks, Arielle Levine, Arun Agrawal, Xavier Basurto, Sara J Breslow, Courtney Carothers, Susan Charnley, Sarah Coulthard, Nives Dolsak, Jamie Donatuto, Carlos Garcia-Quijano, Michael B Mascia, Karma Norman, Melissa R Poe, Terre Satterfield, Kevin St Martin, Phillip S Levin
No abstract text is available yet for this article.
April 1, 2016: Science
Trevor H Worthy, Miyess Mitri, Warren D Handley, Michael S Y Lee, Atholl Anderson, Christophe Sand
The giant flightless bird Sylviornis neocaledoniae (Aves: Sylviornithidae) existed on La Grande Terre and Ile des Pins, New Caledonia, until the late Holocene when it went extinct shortly after human arrival on these islands. The species was generally considered to be a megapode (Megapodiidae) until the family Sylviornithidae was erected for it in 2005 to reflect multiple cranial autapomorphies. However, despite thousands of bones having been reported for this unique and enigmatic taxon, the postcranial anatomy has remained largely unknown...
2016: PloS One
Maria Rosa Dalmau Llorca, Míriam Boira Costa, Carlos López Pablo, Josep Maria Pepió Vilaubí, Carina Aguilar Martin, Emma Forcadell Drago
OBJECTIVE: To estimate the prevalence of occult renal failure (RF) in DM2, by comparing two formulas for estimating glomerular filtration rate (GFR): Modification of Diet in Renal Disease 4 (MDRD-4) and Cockcroft-Gault (CG), as well as their associated clinical variables. DESIGN: Multicentre analytical cross-sectional. LOCATION: Two basic Primary Care areas in Terres de l'Ebre, in North-Eastern Spain. PARTICIPANTS: A total of 493 DM2 patients with age >18years with an assigned doctor in the areas studied...
March 15, 2016: Atencion Primaria
Christoph Neumann, Leo Rizzi, Sven Reichardt, Bernat Terrés, Timofiy Khodkov, Kenji Watanabe, Takashi Taniguchi, Bernd Beschoten, Christoph Stampfer
We present a method to create and erase spatially resolved doping profiles in graphene-hexagonal boron nitride heterostructures. The technique is based on photoinduced doping by a focused laser beam and does neither require masks nor photoresists. This makes our technique interesting for rapid prototyping of unconventional electronic device schemes, where the spatial resolution of the rewritable, long-term stable doping profiles is limited by only the laser spot size (≈600 nm) and the accuracy of sample positioning...
April 13, 2016: ACS Applied Materials & Interfaces
Ruben Tavares, Marc Duclos, Marie-Josée Brabant, Daniella Checchin, Nevzeta Bosnic, Katherine Turvey, Jorge Alfonso Ross Terres
AIMS: To determine whether blood glucose test strip (BGTS) utilization in patients with type 2 diabetes (T2D) is associated with the type of diabetes therapy, classified according to hypoglycemic risk. METHODS: A retrospective, longitudinal (2006-2012) study of Canadian private drug plans (PDP) and Ontario Public Drug Programs (OPDP) prescription claims was conducted. Analyses were restricted to patients with T2D with or without a claim for BGTS. Daily BGTS utilization (TS/patient/day) was evaluated by diabetes therapy classified by hypoglycemic risk...
June 2016: Acta Diabetologica
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