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https://www.readbyqxmd.com/read/29126993/trophic-effect-of-pacap-on-human-corneal-endothelium
#1
Grazia Maugeri, Antonio Longo, Grazia Agata D'Amico, Daniela Maria Rasà, Michele Reibaldi, Andrea Russo, Vincenza Bonfiglio, Teresio Avitabile, Velia D'Agata
Cornea's posterior surface includes endothelium maintaining stromal hydration and clarity. Due to their limited proliferative capability, the loss of endothelial cells can outcome in permanent opacity. In the last years, different studies have demonstrated the protective effect of pituitary adenylate cyclase-activating polypeptide (PACAP) in different ocular diseases. However, its role on human corneal endothelial cells (HCECs) has not been investigated, yet. Here, we have developed a culture protocol to differentiate HCECs from donor's cornea...
November 7, 2017: Peptides
https://www.readbyqxmd.com/read/29062739/pros-and-cons-of-transcatheter-aortic-valve-implantation-tavi
#2
REVIEW
Juan A Terré, Isaac George, Craig R Smith
Transcatheter aortic valve implantation (TAVI) or replacement (TAVR) was recently approved by the FDA for intermediate risk patients with severe aortic stenosis (AS). This technique was already worldwide adopted for inoperable and high-risk patients. Improved device technology, imaging analysis and operator expertise has reduced the initial worrisome higher complications rate associated with TAVR, making it comparable to surgical aortic valve replacement (SAVR). However, many answers need to be addressed before adoption in lower risk patients...
September 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28993215/surveying-selected-european-feed-and-livestock-production-chains-for-features-enabling-the-case-specific-post-market-monitoring-of-livestock-for-intake-and-potential-health-impacts-of-animal-feeds-derived-from-genetically-modified-crops
#3
Gijs Kleter, Sarah McFarland, Alex Bach, Umberto Bernabucci, Paul Bikker, Luca Busani, Esther Kok, Kaloyan Kostov, Anna Nadal, Maria Pla, Bruno Ronchi, Marta Terre, Ralf Einspanier
This review, which has been prepared within the frame of the European Union (EU)-funded project MARLON, surveys the organisation and characteristics of specific livestock and feed production chains (conventional, organic, GM-free) within the EU, with an emphasis on controls, regulations, traceability, and common production practices. Furthermore, an overview of the origin of animal feed used in the EU as well as an examination of the use of genetically modified organisms (GMOs) in feed is provided. From the data, it shows that livestock is traceable at the herd or individual level, depending on the species...
October 6, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28891988/a-multivariate-dynamic-spatial-factor-model-for-speciated-pollutants-and-adverse-birth-outcomes
#4
Kimberly A Kaufeld, Montse Fuentes, Brian J Reich, Amy H Herring, Gary M Shaw, Maria A Terres
Evidence suggests that exposure to elevated concentrations of air pollution during pregnancy is associated with increased risks of birth defects and other adverse birth outcomes. While current regulations put limits on total PM2.5 concentrations, there are many speciated pollutants within this size class that likely have distinct effects on perinatal health. However, due to correlations between these speciated pollutants, it can be difficult to decipher their effects in a model for birth outcomes. To combat this difficulty, we develop a multivariate spatio-temporal Bayesian model for speciated particulate matter using dynamic spatial factors...
September 11, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28883988/the-current-state-of-genetic-counseling-and-newborn-screening-an-interview-with-megan-tucker
#5
Megan Tucker
Megan Tucker talks to Francesca Lake, Managing Editor: A certified genetic counselor for over 10 years, Megan is currently the director of the Indiana State University Genetic Counseling Graduate Program and the Genetic Counseling Clinic at Union Hospital (Terre Haute, IN, USA). She began her career split between the Center for Prenatal Diagnosis and the Medical Genetics and Neurodevelopmental Center at St Vincent Hospital (Indianapolis, IN, USA). During this time she was instrumental in both the development of the statewide Perinatal Loss Evaluation Program and a hospital protocol to ensure collection of cord blood to allow time to effectively genetically evaluate babies...
August 2017: Future Science OA
https://www.readbyqxmd.com/read/28854227/relational-values-resonate-broadly-and-differently-than-intrinsic-or-instrumental-values-or-the-new-ecological-paradigm
#6
Sarah C Klain, Paige Olmsted, Kai M A Chan, Terre Satterfield
Value orientations used to explain or justify conservation have been rooted in arguments about how much and in what context to emphasize the intrinsic versus instrumental value of nature. Equally prominent are characterizations of beliefs known as the New Ecological Paradigm (NEP), often used to help explain pro-environmental behaviour. A recent alternative to these positions has been identified as 'relational value'-broadly, values linking people and ecosystems via tangible and intangible relationships to nature as well as the principles, virtues and notions of a good life that may accompany these...
2017: PloS One
https://www.readbyqxmd.com/read/28831972/influence-of-milk-processing-temperature-on-growth-performance-nitrogen-retention-and-hindgut-s-inflammatory-status-and-bacterial-populations-in-a-calf-model
#7
Alex Bach, Anna Aris, Maria Vidal, Francesc Fàbregas, Marta Terré
This research communication describes a study aimed at evaluating the effects of heat treatment of milk on growth performance, N retention, and hindgut's inflammatory status and bacterial populations using young dairy calves as a model. Twenty-one Holstein calves were randomly allocated to one of three treatments: raw milk (RM), pasteurised milk (PAST), or UHT milk (UHT). Calves were submitted to a N balance study, and a biopsy from the distal colon and a faecal sample were obtained from 5 animals per treatment to determine expression of several genes and potential changes in the hindgut's bacterial population...
August 2017: Journal of Dairy Research
https://www.readbyqxmd.com/read/28790105/impact-of-cytogenetic-abnormalities-in-adults-with-ph-negative-b-cell-precursor-acute-lymphoblastic-leukemia
#8
Marina Lafage-Pochitaloff, Laurence Baranger, Mathilde Hunault, Wendy Cuccuini, Christine Lefebvre, Audrey Bidet, Isabelle Tigaud, Virginie Eclache, Eric Delabesse, Chrystèle Bilhou-Nabéra, Christine Terré, Elise Chapiro, Nathalie Gachard, Marie-Joelle Mozziconacci, Geneviève Ameye, Sarah Porter, Nathalie Grardel, Marie C Béné, Yves Chalandon, Carlos Graux, Françoise Huguet, Véronique Lhéritier, Norbert Ifrah, Hervé Dombret
Multiple cytogenetic subgroups have been described in adult Philadelphia chromosome (Ph)-negative B-cell precursor (BCP) acute lymphoblastic leukemia (ALL), often comprising small numbers of patients. In this study, we aimed to reassess the prognostic value of cytogenetic abnormalities in a large series of 617 adult patients with Ph-negative BCP-ALL (median age, 38 years), treated in the intensified Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL)-2003/2005 trials. Combined data from karyotype, DNA index, fluorescence in situ hybridization, and polymerase chain reaction screening for relevant abnormalities were centrally reviewed and were informative in 542 cases (88%), allowing classification in 10 exclusive primary cytogenetic subgroups and in secondary subgroups, including complex and monosomal karyotypes...
October 19, 2017: Blood
https://www.readbyqxmd.com/read/28767694/group-elicitations-yield-more-consistent-yet-more-uncertain-experts-in-understanding-risks-to-ecosystem-services-in-new-zealand-bays
#9
Gerald G Singh, Jim Sinner, Joanne Ellis, Milind Kandlikar, Benjamin S Halpern, Terre Satterfield, Kai Chan
The elicitation of expert judgment is an important tool for assessment of risks and impacts in environmental management contexts, and especially important as decision-makers face novel challenges where prior empirical research is lacking or insufficient. Evidence-driven elicitation approaches typically involve techniques to derive more accurate probability distributions under fairly specific contexts. Experts are, however, prone to overconfidence in their judgements. Group elicitations with diverse experts can reduce expert overconfidence by allowing cross-examination and reassessment of prior judgements, but groups are also prone to uncritical "groupthink" errors...
2017: PloS One
https://www.readbyqxmd.com/read/28755935/effects-of-feeding-pasteurized-waste-milk-to-dairy-calves-on-phenotypes-and-genotypes-of-antimicrobial-resistance-in-fecal-escherichia-coli-isolates-before-and-after-weaning
#10
G Maynou, L Migura-Garcia, H Chester-Jones, D Ziegler, A Bach, M Terré
The aim of this study was to evaluate the effects of feeding pasteurized waste milk (pWM) to calves on antimicrobial resistance of fecal Escherichia coli at both phenotypic and genotypic levels. Fifty-two Holstein female calves (3 ± 1.3 d of age) were fed 1 of the 2 different types of milk: milk replacer (MR) without antimicrobials or pWM with β-lactam residues until weaning at 49 d of age. Fecal swabs of all calves were obtained on d 0, 35, and 56 of the study and 3 E. coli isolates per sample were studied...
July 26, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28680482/combination-of-t-4-14-del-17p13-del-1p32-and-1q21-gain-fish-probes-identifies-clonal-heterogeneity-and-enhances-the-detection-of-adverse-cytogenetic-profiles-in-233-newly-diagnosed-multiple-myeloma
#11
Thomas Smol, Annika Dufour, Sabine Tricot, Mathieu Wemeau, Laure Stalnikiewicz, Franck Bernardi, Christine Terré, Benoît Ducourneau, Hervé Bisiau, Agnès Daudignon
BACKGROUND: Our aim was to set the FISH combination of del(17p13), t(4;14), 1q21 gain and del(1p32), four adverse cytogenetic factors rarely evaluated together, and compare our technical thresholds with those defined in the literature. METHODS: Two hundred thirty-three patients with MM at diagnosis were studied using FISH to target 4 unfavorable cytogenetic abnormalities: 17p13 deletion, t(4;14) translocation, 1p32 deletion and 1q21 gain. Technical thresholds were determined for each probe using isolated CD138-expressing PC from patients without MM...
2017: Molecular Cytogenetics
https://www.readbyqxmd.com/read/28618317/citizen-science-for-water-quality-monitoring-data-implications-of-citizen-perspectives
#12
Ashlee Jollymore, Morgan J Haines, Terre Satterfield, Mark S Johnson
Citizen science, where citizens play an active role in the scientific process, is increasingly used to expand the reach and scope of scientific research while also achieving engagement and educational goals. Despite the emergence of studies exploring data outcomes of citizen science, the process and experience of engaging with citizens and citizen-lead groups through participatory science is less explored. This includes how citizen perspectives alter data outcomes, a critical upshot given prevalent mistrust of citizen versus scientist data...
June 12, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28551858/cost-effectiveness-of-drug-treatments-for-advanced-melanoma-a-systematic-literature-review
#13
REVIEW
Darío Rubio-Rodríguez, Silvia De Diego Blanco, Maite Pérez, Carlos Rubio-Terrés
BACKGROUND: Until recently, advanced melanoma (unresectable and metastatic) has had a poor prognosis and has been treated with chemotherapy. The introduction of new treatments (BRAF and MEK inhibitors and immunotherapy) has improved overall survival and progression-free survival of some patients. OBJECTIVE: The objective of this study was to review the published evidence on the cost-effectiveness of pharmacological treatments for advanced melanoma. METHODS: A systematic literature search was conducted, without date or language restrictions, in PubMed, EMBASE, Scopus, the Cochrane Library, the UK National Institute for Health and Care Excellence databases and the Health Technology Assessment journal...
May 27, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28549274/mechanisms-and-risk-of-cumulative-impacts-to-coastal-ecosystem-services-an-expert-elicitation-approach
#14
Gerald G Singh, Jim Sinner, Joanne Ellis, Milind Kandlikar, Benjamin S Halpern, Terre Satterfield, Kai M A Chan
Coastal environments are some of the most populated on Earth, with greater pressures projected in the future. Managing coastal systems requires the consideration of multiple uses, which both benefit from and threaten multiple ecosystem services. Thus understanding the cumulative impacts of human activities on coastal ecosystem services would seem fundamental to management, yet there is no widely accepted approach for assessing these. This study trials an approach for understanding the cumulative impacts of anthropogenic change, focusing on Tasman and Golden Bays, New Zealand...
September 1, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28526428/extensively-drug-resistant-bacteria-which-ethical-issues
#15
P Vassal, P Berthelot, J P Chaussinand, S Jay, J P de Filippis, C Auboyer, F Renoux, D Bedoin
OBJECTIVE: The increased bacterial resistance to antibiotics has now become a public health concern. How can we preserve the well-being of patients presenting with infections caused by extensively drug-resistant bacteria (EDRBs) and that of their contacts without inducing any loss of chance of survival, all the while living together and controlling the spread of these EDRBs? METHOD: Terre d'éthique, a French territorial ethics committee, was asked to reflect on this topic by the infection control unit of a French University Hospital as it raises many ethical issues...
May 16, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/28417282/coastal-modification-of-a-scene-employing-multispectral-images-and-vector-operators
#16
Jorge Lira
Changes in sea level, wind patterns, sea current patterns, and tide patterns have produced morphologic transformations in the coastline area of Tamaulipas Sate in North East Mexico. Such changes generated a modification of the coastline and variations of the texture-relief and texture of the continental area of Tamaulipas. Two high-resolution multispectral satellite Satellites Pour l'Observation de la Terre images were employed to quantify the morphologic change of such continental area. The images cover a time span close to 10 years...
May 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28323765/misuse-of-opioids-in-orthopaedic-postoperative-patients
#17
MULTICENTER STUDY
Anup Gangavalli, Ajith Malige, George Terres, Saqib Rehman, Chinenye Nwachuku
OBJECTIVE: In light of the recent uptrend in the prescription of opioids, this study seeks to identify patterns of opioid misuse among orthopaedic postoperative patients and principal external sources in obtaining these medications. DESIGN: Ten-month survey-based study. SETTING: Two Level I trauma centers (urban and suburban). PATIENTS/PARTICIPANTS: Two hundred seven patients between the ages of 18 and 89 years who underwent surgical fixation of fractures involving the pelvis, long bones, or periarticular regions of the knee, ankle, elbow, and wrist...
April 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28221862/randomized-phase-ii-study-of-clofarabine-based-consolidation-for-younger-adults-with-acute-myeloid-leukemia-in-first-remission
#18
RANDOMIZED CONTROLLED TRIAL
Xavier Thomas, Stéphane de Botton, Sylvie Chevret, Denis Caillot, Emmanuel Raffoux, Emilie Lemasle, Jean-Pierre Marolleau, Céline Berthon, Arnaud Pigneux, Norbert Vey, Oumedaly Reman, Marc Simon, Christian Recher, Jean-Yves Cahn, Olivier Hermine, Sylvie Castaigne, Karine Celli-Lebras, Norbert Ifrah, Claude Preudhomme, Christine Terré, Hervé Dombret
Purpose To evaluate the efficacy and safety of a clofarabine-based combination (CLARA) versus conventional high-dose cytarabine (HDAC) as postremission chemotherapy in younger patients with acute myeloid leukemia (AML). Patients and Methods Patients age 18 to 59 years old with intermediate- or unfavorable-risk AML in first remission and no identified donor for allogeneic stem-cell transplantation (SCT) were eligible. Two hundred twenty-one patients were randomly assigned to receive three CLARA or three HDAC consolidation cycles...
April 10, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28220677/toward-a-sociology-of-oceans
#19
John Hannigan
Despite covering around 70 percent of the earth's surface, the ocean has long been ignored by sociology or treated as merely an extension of land-based systems. Increasingly, however, oceans are assuming a higher profile, emerging both as a new resource frontier, a medium for geopolitical rivalry and conflict, and a unique and threatened ecological hot spot. In this article, I propose a new sociological specialty area, the "sociology of oceans" to be situated at the interface between environmental sociology and traditional maritime studies...
February 2017: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/28215892/feeding-of-waste-milk-to-holstein-calves-affects-antimicrobial-resistance-of-escherichia-coli-and-pasteurella-multocida-isolated-from-fecal-and-nasal-swabs
#20
G Maynou, A Bach, M Terré
The use of milk containing antimicrobial residues in calf feeding programs has been shown to select for resistant fecal Escherichia coli in dairy calves. However, information is scarce about the effects of feeding calves waste milk (WM) on the prevalence of multidrug-resistant bacteria. The objective of this study was to determine the antimicrobial resistance patterns of fecal E. coli and nasal Pasteurella multocida isolates from calves fed either milk replacer (MR) or WM in 8 commercial dairy farms (4 farms per feeding program)...
April 2017: Journal of Dairy Science
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