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https://www.readbyqxmd.com/read/28526428/extensively-drug-resistant-bacteria-which-ethical-issues
#1
P Vassal, P Berthelot, J P Chaussinand, S Jay, J P de Filippis, C Auboyer, F Renoux, D Bedoin
OBJECTIVE: The increased bacterial resistance to antibiotics has now become a public health concern. How can we preserve the well-being of patients presenting with infections caused by extensively drug-resistant bacteria (EDRBs) and that of their contacts without inducing any loss of chance of survival, all the while living together and controlling the spread of these EDRBs? METHOD: Terre d'éthique, a French territorial ethics committee, was asked to reflect on this topic by the infection control unit of a French University Hospital as it raises many ethical issues...
May 16, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/28417282/coastal-modification-of-a-scene-employing-multispectral-images-and-vector-operators
#2
Jorge Lira
Changes in sea level, wind patterns, sea current patterns, and tide patterns have produced morphologic transformations in the coastline area of Tamaulipas Sate in North East Mexico. Such changes generated a modification of the coastline and variations of the texture-relief and texture of the continental area of Tamaulipas. Two high-resolution multispectral satellite Satellites Pour l'Observation de la Terre images were employed to quantify the morphologic change of such continental area. The images cover a time span close to 10 years...
May 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28323765/misuse-of-opioids-in-orthopaedic-postoperative-patients
#3
Anup Gangavalli, Ajith Malige, George Terres, Saqib Rehman, Chinenye Nwachuku
OBJECTIVE: In light of the recent uptrend in the prescription of opioids, this study seeks to identify patterns of opioid misuse among orthopaedic postoperative patients and principal external sources in obtaining these medications. DESIGN: Ten-month survey-based study. SETTING: Two Level I trauma centers (urban and suburban). PATIENTS/PARTICIPANTS: Two hundred seven patients between the ages of 18 and 89 years who underwent surgical fixation of fractures involving the pelvis, long bones, or periarticular regions of the knee, ankle, elbow, and wrist...
April 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28221862/randomized-phase-ii-study-of-clofarabine-based-consolidation-for-younger-adults-with-acute-myeloid-leukemia-in-first-remission
#4
Xavier Thomas, Stéphane de Botton, Sylvie Chevret, Denis Caillot, Emmanuel Raffoux, Emilie Lemasle, Jean-Pierre Marolleau, Céline Berthon, Arnaud Pigneux, Norbert Vey, Oumedaly Reman, Marc Simon, Christian Recher, Jean-Yves Cahn, Olivier Hermine, Sylvie Castaigne, Karine Celli-Lebras, Norbert Ifrah, Claude Preudhomme, Christine Terré, Hervé Dombret
Purpose To evaluate the efficacy and safety of a clofarabine-based combination (CLARA) versus conventional high-dose cytarabine (HDAC) as postremission chemotherapy in younger patients with acute myeloid leukemia (AML). Patients and Methods Patients age 18 to 59 years old with intermediate- or unfavorable-risk AML in first remission and no identified donor for allogeneic stem-cell transplantation (SCT) were eligible. Two hundred twenty-one patients were randomly assigned to receive three CLARA or three HDAC consolidation cycles...
April 10, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28220677/toward-a-sociology-of-oceans
#5
John Hannigan
Despite covering around 70 percent of the earth's surface, the ocean has long been ignored by sociology or treated as merely an extension of land-based systems. Increasingly, however, oceans are assuming a higher profile, emerging both as a new resource frontier, a medium for geopolitical rivalry and conflict, and a unique and threatened ecological hot spot. In this article, I propose a new sociological specialty area, the "sociology of oceans" to be situated at the interface between environmental sociology and traditional maritime studies...
February 2017: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/28215892/feeding-of-waste-milk-to-holstein-calves-affects-antimicrobial-resistance-of-escherichia-coli-and-pasteurella-multocida-isolated-from-fecal-and-nasal-swabs
#6
G Maynou, A Bach, M Terré
The use of milk containing antimicrobial residues in calf feeding programs has been shown to select for resistant fecal Escherichia coli in dairy calves. However, information is scarce about the effects of feeding calves waste milk (WM) on the prevalence of multidrug-resistant bacteria. The objective of this study was to determine the antimicrobial resistance patterns of fecal E. coli and nasal Pasteurella multocida isolates from calves fed either milk replacer (MR) or WM in 8 commercial dairy farms (4 farms per feeding program)...
April 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28135298/explicit-not-implicit-preferences-predict-conservation-intentions-for-endangered-species-and-biomes
#7
Alejandra Echeverri, Megan M Callahan, Kai M A Chan, Terre Satterfield, Jiaying Zhao
Conservation of biodiversity is determined in part by human preferences. Preferences relevant to conservation have been examined largely via explicit measures (e.g., a self-reported degree of liking), with implicit measures (e.g., preconscious, automatic evaluations) receiving relatively less attention. This is the case despite psychological evidence from other contexts that implicit preferences are more informative of behavior. Thus, the type of measure that predicts conservation intentions for biodiversity is unknown...
2017: PloS One
https://www.readbyqxmd.com/read/28131241/letter-to-the-editor-a-response-to-kertz-2017-extension-and-clarification-of-a-call-for-more-complete-reporting-and-evaluation-of-experimental-methods-physical-forms-of-starters-and-results-in-calf-research
#8
https://www.readbyqxmd.com/read/28115858/cost-effectiveness-analysis-of-combination-antifungal-therapy-with-voriconazole-and-anidulafungin-versus-voriconazole-monotherapy-for-primary-treatment-of-invasive-aspergillosis-in-spain
#9
Santiago Grau, Jose Ramon Azanza, Isabel Ruiz, Carlos Vallejo, Josep Mensa, Johan Maertens, Werner J Heinz, Jon Andoni Barrueta, Carmen Peral, Francisco Jesús Mesa, Miguel Barrado, Claudie Charbonneau, Darío Rubio-Rodríguez, Carlos Rubio-Terrés
OBJECTIVE: According to a recent randomized, double-blind clinical trial comparing the combination of voriconazole and anidulafungin (VOR+ANI) with VOR monotherapy for invasive aspergillosis (IA) in patients with hematologic disease or with hematopoietic stem cell transplant, mortality was lower after 6 weeks with VOR+ANI than with VOR monotherapy in a post hoc analysis of patients with galactomannan-based IA. The objective of this study was to compare the cost-effectiveness of VOR+ANI with VOR, from the perspective of hospitals in the Spanish National Health System...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/28115857/costs-of-adverse-events-associated-with-erlotinib-or-afatinib-in-first-line-treatment-of-advanced-egfr-positive-non-small-cell-lung-cancer
#10
Dolores Isla, Javier De Castro, Oscar Juan, Santiago Grau, Javier Orofino, Rocío Gordo, Carlos Rubio-Terrés, Darío Rubio-Rodríguez
OBJECTIVES: Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are an established treatment for advanced non-small cell lung cancer (NSCLC) with EGFR mutation. According to published meta-analyses, no significant efficacy differences have been demonstrated between erlotinib and afatinib. However, the incidence of EGFR-TKI-related adverse events (AEs) was lower with erlotinib. This study compares the cost of management of the AEs associated with these two drugs from the perspective of the Spanish National Health System (NHS)...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/28056203/postinduction-minimal-residual-disease-predicts-outcome-and-benefit-from-allogeneic-stem-cell-transplantation-in-acute-myeloid-leukemia-with-npm1-mutation-a-study-by-the-acute-leukemia-french-association-group
#11
Marie Balsat, Aline Renneville, Xavier Thomas, Stéphane de Botton, Denis Caillot, Alice Marceau, Emilie Lemasle, Jean-Pierre Marolleau, Olivier Nibourel, Céline Berthon, Emmanuel Raffoux, Arnaud Pigneux, Céline Rodriguez, Norbert Vey, Jean-Michel Cayuela, Sandrine Hayette, Thorsten Braun, Marie Magdeleine Coudé, Christine Terre, Karine Celli-Lebras, Hervé Dombret, Claude Preudhomme, Nicolas Boissel
Purpose This study assessed the prognostic impact of postinduction NPM1-mutated ( NPM1m) minimal residual disease (MRD) in young adult patients (age, 18 to 60 years) with acute myeloid leukemia, and addressed the question of whether NPM1m MRD may be used as a predictive factor of allogeneic stem cell transplantation (ASCT) benefit. Patients and Methods Among 229 patients with NPM1m who were treated in the Acute Leukemia French Association 0702 (ALFA-0702) trial, MRD evaluation was available in 152 patients in first remission...
January 10, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28043358/the-acute-effect-of-intravenous-lipopolysaccharide-injection-on-serum-and-intrafollicular-hdl-components-and-gene-expression-in-granulosa-cells-of-the-bovine-dominant-follicle
#12
Felipe Terres de Campos, Joao Aveiro Alvarado Rincon, Diego Andres Velasco Acosta, Pedro Augusto Silva Silveira, Jorgea Pradieé, Marcio Nunes Corrêa, Bernardo Garziera Gasperin, Luiz Francisco Machado Pfeifer, Carlos Castilho Barros, Ligia Margareth Cantareli Pegoraro, Augusto Schneider
The aim of this study was to evaluate the effect of an acute systemic inflammatory response induced by lipopolysaccharide (LPS) in the serum and follicular fluid (FF) high-density lipoprotein (HDL) components, hormone concentrations and granulosa cell gene expression. For this purpose, twenty non-lactating Jersey dairy cows were submitted to a progesterone (P4) - estradiol (E2) based synchronization protocol. Cows received a single i.v. dose of LPS (2.5 μg/kg of body weight) or saline solution (CTL Group) 2 h after P4 insert removal...
February 2017: Theriogenology
https://www.readbyqxmd.com/read/28039322/injuries-to-the-aorta-aortic-annulus-and-left-ventricle-during-transcatheter-aortic-valve-replacement-management-and-outcomes
#13
Nathaniel B Langer, Nadira B Hamid, Tamim M Nazif, Omar K Khalique, Torsten P Vahl, Jonathon White, Juan Terre, Ramin Hastings, Diana Leung, Rebecca T Hahn, Martin Leon, Susheel Kodali, Isaac George
The experience with transcatheter aortic valve replacement is increasing worldwide; however, the incidence of potentially catastrophic cardiac or aortic complications has not decreased. In most cases, significant injuries to the aorta, aortic valve annulus, and left ventricle require open surgical repair. However, the transcatheter aortic valve replacement patient presents a unique challenge as many patients are at high or prohibitive surgical risk and, therefore, an open surgical procedure may not be feasible or appropriate...
January 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27898790/assessment-of-carbon-stocks-in-the-topsoil-using-random-forest-and-remote-sensing-images
#14
Jongsung Kim, Sabine Grunwald
Wetland soils are able to exhibit both consumption and production of greenhouse gases, and they play an important role in the regulation of the global carbon (C) cycle. Still, it is challenging to accurately evaluate the actual amount of C stored in wetlands. The incorporation of remote sensing data into digital soil models has great potential to assess C stocks in wetland soils. Our objectives were (i) to develop C stock prediction models utilizing remote sensing images and environmental ancillary data, (ii) to identify the prime environmental predictor variables that explain the spatial distribution of soil C, and (iii) to assess the amount of C stored in the top 20-cm soils of a prominent nutrient-enriched wetland...
November 2016: Journal of Environmental Quality
https://www.readbyqxmd.com/read/27896970/empowering-multi-cohort-gene-expression-analysis-to-increase-reproducibility
#15
Winston A Haynes, Francesco Vallania, Charles Liu, Erika Bongen, Aurelie Tomczak, Marta Andres-Terrè, Shane Lofgren, Andrew Tam, Cole A Deisseroth, Matthew D Li, Timothy E Sweeney, Purvesh Khatri
A major contributor to the scientific reproducibility crisis has been that the results from homogeneous, single-center studies do not generalize to heterogeneous, real world populations. Multi-cohort gene expression analysis has helped to increase reproducibility by aggregating data from diverse populations into a single analysis. To make the multi-cohort analysis process more feasible, we have assembled an analysis pipeline which implements rigorously studied meta-analysis best practices. We have compiled and made publicly available the results of our own multi-cohort gene expression analysis of 103 diseases, spanning 615 studies and 36,915 samples, through a novel and interactive web application...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27798553/misuse-of-opioids-in-orthopaedic-post-operative-patients
#16
Gangavalli Anup, Malige Ajith, Terres George, Rehman Saqib, Nwachuku Chinenye
OBJECTIVE: In light of the recent uptrend in the prescription of opioids, this study seeks to identify patterns of opioid misuse among orthopaedic post-operative patients and principal external sources in obtaining these medications. DESIGN: Ten-month survey based study. SETTING: Two Level-I trauma centers (urban and suburban). PATIENTS/PARTICIPANTS: 207 patients between the ages of 18 to 89 years who underwent surgical fixation of fractures involving the pelvis, long bones or peri-articular regions of the knee, ankle, elbow and wrist...
October 26, 2016: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/27707673/cytogenetics-in-the-management-of-multiple-myeloma-an-update-by-the-groupe-francophone-de-cytog%C3%A3-n%C3%A3-tique-h%C3%A3-matologique-gfch
#17
REVIEW
Agnès Daudignon, Benoît Quilichini, Geneviève Ameye, Hélène Poirel, Christian Bastard, Christine Terré
Cytogenetics of multiple myeloma has evolved in recent years by the emergence of Interphasic fluorescence in situ hybridization (FISH) performed on sorted plasma cells detecting abnormalities independently of a proliferative and infiltrative index. Cytogenetic analysis plays a major part in the risk stratification of myeloma diagnosis due to prognostic impact of various cytogenetic abnormalities as well as to the association between emerging therapeutic approaches in MM. Thus, practice guidelines now recommend interphasic FISH or alternative molecular technics as the initial analysis for multiple myeloma...
October 1, 2016: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/27703384/economic-evaluation-of-obinutuzumab-in-combination-with-chlorambucil-in-first-line-treatment-of-patients-with-chronic-lymphocytic-leukemia-in-spain
#18
Luis Felipe Casado, Amparo Burgos, Eva González-Haba, Javier Loscertales, Tania Krivasi, Javier Orofino, Carlos Rubio-Terres, Darío Rubio-Rodríguez
OBJECTIVE: To evaluate the cost-effectiveness of obinutuzumab in combination with chlorambucil (GClb) versus rituximab plus chlorambucil (RClb) in the treatment of adults with previously untreated chronic lymphocytic leukemia (CLL) and with comorbidities that make them unsuitable for full-dose fludarabine-based therapy, from the perspective of the Spanish National Health System. METHODS: A Markov model was developed with three mutually exclusive health states: progression-free survival (with or without treatment), progression, and death...
2016: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/27686867/copy-number-analysis-identified-new-prognostic-marker-in-acute-myeloid-leukemia
#19
O Nibourel, S Guihard, C Roumier, N Pottier, C Terre, A Paquet, P Peyrouze, S Geffroy, S Quentin, A Alberdi, R B Abdelali, A Renneville, C Demay, K Celli-Lebras, P Barbry, B Quesnel, S Castaigne, H Dombret, J Soulier, C Preudhomme, M H Cheok
Recent advances in genomic technologies have revolutionized acute myeloid leukemia (AML) understanding by identifying potential novel actionable genomic alterations. Consequently, current risk stratification at diagnosis not only relies on cytogenetics, but also on the inclusion of several of these abnormalities. Despite this progress, AML remains a heterogeneous and complex malignancy with variable response to current therapy. Although copy-number alterations (CNAs) are accepted prognostic markers in cancers, large-scale genomic studies aiming at identifying specific prognostic CNA-based markers in AML are still lacking...
November 4, 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/27645100/diversity-of-methane-oxidizing-bacteria-in-soils-from-hot-lands-of-medolla-italy-featured-by-anomalous-high-temperatures-and-biogenic-co2-emission
#20
Martina Cappelletti, Daniele Ghezzi, Davide Zannoni, Bruno Capaccioni, Stefano Fedi
"Terre Calde di Medolla" (TCM) (literally, "Hot Lands of Medolla") refers to a farming area in Italy with anomalously high temperatures and diffuse emissions of biogenic CO2, which has been linked to CH4 oxidation processes from a depth of 0.7 m to the surface. We herein assessed the composition of the total bacterial community and diversity of methane-oxidizing bacteria (MOB) in soil samples collected at a depth at which the peak temperature was detected (0.6 m). Cultivation-independent methods were used, such as: i) a clone library analysis of the 16S rRNA gene and pmoA (coding for the α-subunit of the particulate methane monooxygenase) gene, and ii) Terminal Restriction Fragment Length Polymorphism (T-RFLP) fingerprinting...
December 23, 2016: Microbes and Environments
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