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https://www.readbyqxmd.com/read/28340297/atomic-scale-snapshots-of-the-formation-and-growth-of-hollow-ptni-c-nanocatalysts
#1
Raphael Chattot, Tristan Asset, Jakub Drnec, Pierre Bordet, Jaysen Nelayah, Laetitia Dubau, Frédéric Maillard
Determining the formation and growth mechanism of bimetallic nanoparticles (NPs) with atomic detail is fundamental to synthesize efficient 'catalysts by design'. However, the understanding of the elementary steps, which take place during their synthesis remains elusive. Herein, we have exploited scanning transmission electron microscopy coupled to energy dispersive X-ray spectroscopy, operando wide angle and small angle X-ray scattering and electrochemistry to unveil the formation and growth mechanism of hollow PtNi/C NPs...
March 24, 2017: Nano Letters
https://www.readbyqxmd.com/read/28340286/bringing-the-world-of-child-neurology-together
#2
EDITORIAL
Jean-Pierre Lin
No abstract text is available yet for this article.
January 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28340096/dual-vs-single-chamber-defibrillators-for-primary-prevention-of-sudden-cardiac-death-long-term-follow-up-of-the-d%C3%A3-fibrillateur-automatique-implantable-pr%C3%A3-vention-primaire-registry
#3
Pascal Defaye, Serge Boveda, Didier Klug, Frankie Beganton, Olivier Piot, Kumar Narayanan, Marie-Cécile Périer, Daniel Gras, Laurent Fauchier, Pierre Bordachar, Vincent Algalarrondo, Dominique Babuty, Jean-Claude Deharo, Christophe Leclercq, Eloi Marijon, Nicolas Sadoul
Aims: Implantable cardioverter defibrillators (ICDs) are an effective primary prevention of sudden cardiac death. We examined whether dual-chamber (DC) ICDs confer a greater benefit than single-chamber (SC) ICDs, and compared the long-term outcomes of recipients of each type of device implanted for primary prevention. Methods and results: Between 2002 and 2012, the DAI-PP registry consecutively enrolled 1258 SC- and 1280 DC-ICD recipients at 12 French medical centres...
March 8, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28340056/neutrophil-derived-mitochondrial-dna-promotes-receptor-activator-of-nuclear-factor-%C3%AE%C2%BAb-and-its-ligand-signalling-in-rheumatoid-arthritis
#4
Anne Contis, Stéphane Mitrovic, Julie Lavie, Isabelle Douchet, Estibaliz Lazaro, Marie-Elise Truchetet, Cyril Goizet, Cécile Contin-Bordes, Thierry Schaeverbeke, Patrick Blanco, Rodrigue Rossignol, Benjamin Faustin, Christophe Richez, Pierre Duffau
Objectives.: Mitochondrial DNA (mtDNA) contains sequestered damage-associated molecular patterns that might be involved in osteoimmunological pathogenesis of RA. Here, we aimed to investigate the cellular source of mtDNA and its role in RANK ligand (RANKL) expression by RA SF neutrophils. Methods.: The gene expression signature of SF neutrophils was examined by proteomic quantitative analysis. Levels of mtDNA in circulating and SF neutrophils from RA patients and OA control subjects were assessed by real-time PCR...
March 13, 2017: Rheumatology
https://www.readbyqxmd.com/read/28339999/bone-curvature-changes-can-predict-the-impact-of-treatment-on-cartilage-volume-loss-in-knee-osteoarthritis-data-from-a-2-year-clinical-trial
#5
Jean-Pierre Raynauld, Jean-Pierre Pelletier, Philippe Delorme, Pierre Dodin, François Abram, Johanne Martel-Pelletier
Objectives.: Knee bone curvature assessed by MRI was associated with OA cartilage loss. A recent knee OA trial demonstrated the superiority of chondroitin sulfate over celecoxib (comparator) at reducing cartilage volume loss (CVL) in the medial compartment (condyle). The main objectives were to identify which baseline bone curvature regions of interest (BCROI) best associated with CVL and investigate whether baseline BCROI and 2-year change are correlated with the protective effect of chondroitin sulphate on CVL...
March 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28339853/prosurvival-effect-of-cumulus-prostaglandin-g-h-synthase-2-prostaglandin2-signaling-on-bovine-blastocyst-impact-on-in-vivo-posthatching-development%C3%A2
#6
Fabienne Nuttinck, Alice Jouneau, Gilles Charpigny, Isabelle Hue, Christophe Richard, Pierre Adenot, Sylvie Ruffini, Ludivine Laffont, Martine Chebrout, Véronique Duranthon, Brigitte Marquant-Le Guienne
Apoptotic activity is a common physiological process which culminates at the blastocyst stage in the preimplantation embryo of many mammals. The degree of embryonic cell death can be influenced by the oocyte microenvironment. However, the prognostic significance of the incidence of apoptosis remains undefined. Prostaglandin E2 (PGE2) derived from prostaglandin G/H synthase-2 (PTGS2) activity is a well-known prosurvival factor that is mainly studied in oncology. PGE2 is the predominant PTGS2-derived prostaglandin present in the oocyte microenvironment during the periconceptional period...
March 7, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28339803/transcriptional-comparison-of-myogenesis-in-leghorn-and-low-score-normal-embryos
#7
J Griffin, N St-Pierre, M S Lilburn, M Wick
In a previous study, we reported on a quantitative transcriptomic method which confirmed the temporal transcription of developmental fast skeletal muscle myosin heavy chain (fsMyHC) embryonic isoforms in the embryonic Pectoralis major (PM) of the Single Comb White Leghorn (SCWL). The objective of the current study was to further investigate the transcriptional events underlying embryonic PM growth in the SCWL and a genotype exhibiting partial muscular dystrophy, the Low Score Normal (LSN). We hypothesized that within the SCWL and LSN embryos, there would be differences in the temporal transcription of the fsMyHC isoforms and other myogenic regulatory genes...
February 21, 2017: Poultry Science
https://www.readbyqxmd.com/read/28339706/differential-proliferation-and-metabolic-activity-of-sertoli-cells-in-the-testes-of-broiler-and-layer-breeder-chickens
#8
Mélanie Faure, Edith Guibert, Sabine Crochet, Pascal Chartrin, Jean-Pierre Brillard, Anne Collin, Pascal Froment
Decades of genetic selection have generated 2 different, highly specialized types of chickens in which 1 type, known as the layer-type chicken, expresses high laying performance while the other type, known as the broiler-type chicken, is dedicated to the production of fast-growing birds. Selected lines for the latter type often express disorders in their reproductive performance including early sexual maturation and accelerated, non-reversible seasonal decline of their semen production and mating behavior. The aim of the present study was to characterize some metabolic markers of the Sertoli cell populations...
February 21, 2017: Poultry Science
https://www.readbyqxmd.com/read/28339683/addressing-beacon-re-identification-attacks-quantification-and-mitigation-of-privacy-risks
#9
Jean Louis Raisaro, Florian Tramèr, Zhanglong Ji, Diyue Bu, Yongan Zhao, Knox Carey, David Lloyd, Heidi Sofia, Dixie Baker, Paul Flicek, Suyash Shringarpure, Carlos Bustamante, Shuang Wang, Xiaoqian Jiang, Lucila Ohno-Machado, Haixu Tang, XiaoFeng Wang, Jean-Pierre Hubaux
The Global Alliance for Genomics and Health (GA4GH) created the Beacon Project as a means of testing the willingness of data holders to share genetic data in the simplest technical context-a query for the presence of a specified nucleotide at a given position within a chromosome. Each participating site (or "beacon") is responsible for assuring that genomic data are exposed through the Beacon service only with the permission of the individual to whom the data pertains and in accordance with the GA4GH policy and standards...
February 20, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28339296/synthetic-parasites-a-successful-mucosal-nanoparticle-vaccine-against-toxoplasma-congenital-infection-in-mice
#10
Céline Ducournau, Thi Tl Nguyen, Rodolphe Carpentier, Isabelle Lantier, Stéphanie Germon, Flavien Précausta, Pierre-Jean Pisella, Hervé Leroux, Nathalie Van Langendonck, Didier Betbeder, Isabelle Dimier-Poisson
AIM: Development of protein vaccine to prevent congenital infection is a major public health priority. Our goal is the design of mucosal synthetic pathogen inducing protective immune responses against congenital toxoplasmosis. MATERIALS & METHODS: Mice were immunized intranasally, establishing pregnancy and challenging orally. Placental immune response, congenital infection, pup growth, parasitic load rates were studied. RESULTS: Pups born to vaccinated infected dams had significantly fewer brain cysts, no intraocular inflammation and normal growth...
March 24, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28339192/a-novel-exposure-system-termed-navetta-for-in-vitro-laminar-flow-electrodeposition-of-nanoaerosol-and-evaluation-of-immune-effects-in-human-lung-reporter-cells
#11
Evelien Frijns, Sandra Verstraelen, Linda Corinna Stoehr, Jo van Laer, An Jacobs, Jan Peters, Kristof Tirez, Matthew Boyles, Mark Geppert, Pierre Madl, Inge Nelissen, Albert Duschl, Martin Himly
A new prototype air-liquid interface (ALI) exposure system, a flatbed aerosol exposure chamber termed NAVETTA, was developed to investigate deposition of engineered nanoparticles (NPs) on cultured human lung A549 cells directly from the gas phase. This device mimics human lung cell exposure to NPs due to a low horizontal gas flow combined with cells exposed at the ALI. Electrostatic field assistance is applied to improve NP deposition efficiency. As proof-of-principle, cell viability and immune responses after short-term exposure to nano-copper oxide (CuO)-aerosol were determined...
March 24, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28338834/comparative-genomics-of-microsporidian-genomes-reveals-a-minimal-non-coding-rna-set-and-new-insights-for-transcription-in-minimal-eukaryotic-genomes
#12
Abdel Belkorchia, Jean-François Pombert, Valérie Polonais, Nicolas Parisot, Frédéric Delbac, Jean-François Brugère, Pierre Peyret, Christine Gaspin, Eric Peyretaillade
Microsporidia are ubiquitous intracellular pathogens whose opportunistic nature led to their increased recognition with the rise of the AIDS pandemic. As the RNA world was largely unexplored in this parasitic lineage, we developed a dedicated in silico methodology to carry out exhaustive identification of ncRNAs across the Encephalitozoon and Nosema genera. Thus, the previously missing U1 small nuclear RNA (snRNA) and small nucleolar RNAs (snoRNAs) targeting only the LSU rRNA were highlighted and were further validated using 5' and 3'RACE-PCR experiments...
February 28, 2017: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
https://www.readbyqxmd.com/read/28338833/a-humidity-shock-leads-to-rapid-temperature-dependent-changes-in-coffee-leaf-physiology-and-gene-expression
#13
El-Hadji Thioune, James McCarthy, Thomas Gallagher, Bruce Osborne
Climate change is expected to increase the frequency of above-normal atmospheric water deficits contemporaneous with periods of high temperatures. Here we explore alterations in physiology and gene expression in leaves of Coffea canephora Pierre ex A. Froehner caused by a sharp drop in relative humidity (RH) at three different temperatures. Both stomatal conductance (gs) and CO2 assimilation (A) measurements showed that gs and A values fell quickly at all temperatures after the transfer to low RH.  However, leaf relative water content measurements indicated that leaves nonetheless experienced substantial water losses, implying that stomatal closure and/or resupply of water was not fast enough to stop excessive evaporative losses...
February 8, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28338676/dirhamnolipids-secreted-from-pseudomonas-aeruginosa-modify-anjpegungal-susceptibility-of-aspergillus-fumigatus-by-inhibiting-%C3%AE-1-3-glucan-synthase-activity
#14
Benoit Briard, Vero Rasoldier, Perrine Bomme, Noureddine ElAouad, Catherine Guerreiro, Pierre Chassagne, Laetitia Muszkieta, Jean-Paul Latgé, Laurence Mulard, Anne Beauvais
Pseudomonas aeruginosa and Aspergillus fumigatus are the two microorganisms responsible for most of the chronic infections in cystic fibrosis patients. P. aeruginosa is known to produce quorum-sensing controlled rhamnolipids during chronic infections. Here we show that the dirhamnolipids secreted from P. aeruginosa (i) induce A. fumigatus to produce an extracellular matrix, rich in galactosaminogalactan, 1,8-dihydroxynaphthalene (DHN)- and pyo-melanin, surrounding their hyphae, which facilitates P. aeruginosa binding and (ii) inhibit A...
March 24, 2017: ISME Journal
https://www.readbyqxmd.com/read/28338635/a-formaldehyde-sensor-based-on-molecularly-imprinted-polymer-on-a-tio%C3%A2-nanotube-array
#15
Xiaohui Tang, Jean-Pierre Raskin, Driss Lahem, Arnaud Krumpmann, André Decroly, Marc Debliquy
Today, significant attention has been brought to the development of sensitive, specific, cheap, and reliable sensors for real-time monitoring. Molecular imprinting technology is a versatile and promising technology for practical applications in many areas, particularly chemical sensors. Here, we present a chemical sensor for detecting formaldehyde, a toxic common indoor pollutant gas. Polypyrrole-based molecularly-imprinted polymer (PPy-based MIP) is employed as the sensing recognition layer and synthesized on a titanium dioxide nanotube array (TiO₂-NTA) for increasing its surface-to-volume ratio, thereby improving the sensor performance...
March 24, 2017: Sensors
https://www.readbyqxmd.com/read/28338579/correlative-analysis-of-vertebral-trabecular-bone-microarchitecture-and-mechanical-properties-a-combined-ultra-high-field-7-tesla-mri-and-biomechanical-investigation
#16
Daphne Guenoun, Alexandre Fouré, Martine Pithioux, Sandrine Guis, Thomas Le Corroller, Jean-Pierre Mattei, Vanessa Pauly, Maxime Guye, Monique Bernard, Patrick Chabrand, Pierre Champsaur, David Bendahan
STUDY DESIGN: High resolution imaging and biomechanical investigation of ex-vivo vertebrae OBJECTIVE.: To assess bone microarchitecture of cadaveric vertebrae using ultra-high field (UHF) 7 Tesla magnetic resonance imaging (MRI) and to determine whether the corresponding microarchitecture parameters were related to BMD and bone strength assessed by dual energy X-ray absorptiometry (DXA) and mechanical compression tests. SUMMARY OF BACKGROUND DATA: Limitations of DXA for the assessment of bone fragility and osteoporosis have been recognized and criteria of microarchitecture alteration have been included in the definition of osteoporosis...
March 23, 2017: Spine
https://www.readbyqxmd.com/read/28338355/the-potential-for-a-targeted-strength-training-programme-to-decrease-asymmetry-and-increase-performance-a-proof-of-concept-in-sprinting
#17
Scott R Brown, Erin R Feldman, Matt R Cross, Eric R Helms, Bruno Marrier, Pierre Samozino, Jean-Benoît Morin
The global application of horizontal force (FH) via hip extension is related to improvements in sprint performance (e.g. maximal velocity [vmax] and power [Pmax]). Little is known regarding the contribution of individual-leg FH and how a difference between the legs (asymmetry) might subsequently affect sprint performance. We assessed a single male athlete for pre-post outcomes of a targeted hip extension training programme on FH asymmetry and sprint performance metrics. An instrumented non-motorised treadmill was used to obtain individual-leg and global sprint kinetics and determine the athlete's strong and weak leg, with regards to the ability to produce FH while sprinting...
March 24, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28338319/postmetalated-zirconium-metal-organic-frameworks-as-a-highly-potent-bactericide
#18
Boushra Mortada, Tamara Abou Matar, Aya Sakaya, Hala Atallah, Zeinab Kara Ali, Pierre Karam, Mohamad Hmadeh
Metal-organic frameworks (MOFs) have emerged as an important class of hybrid organic-inorganic materials. One of the reasons they have gained remarkable attention is attributed to the possibility of altering them by postsynthetic modification, thereby providing access to new and novel advanced materials. MOFs have been applied in catalysis, gas storage, gas separation, chemical sensing, and drug delivery. However, their bactericidal use has rarely been explored. Herein, we developed a two-step process for the synthesis of zirconium-based MOFs metalated with silver cations as a potent antibacterial agent...
March 24, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28338296/photochromism-and-dual-color-fluorescence-in-a-polyoxometalate-benzospiropyran-molecular-switch
#19
Arnaud Parrot, Aurélie Bernard, Aurélie Jacquart, Stefano Artin Serapian, Carles Bo, Etienne Derat, Olivier Oms, Anne Dolbecq, Anna Proust, Rémi Métivier, Pierre Mialane, Guillaume Izzet
The photophysical properties of a Keggin-type polyoxometalate (POM) covalently bounded to a benzospiropyran (BSPR) unit have been investigated. These studies reveal that both closed and open forms are emissive with distinct spectral features (λem (closed form)=530 nm, λem (open form)=670 nm) and that the fluorescence of the BSPR unit of the hybrid is considerably enhanced compared to BSPR parent compounds. While the fluorescence excitation energy of the BSPR reference compounds (370 nm) is close to the intense absorption responsible of the photochromic character (350 nm), the fluorescence excitation of the hybrid is shifted to lower energy (400 nm), improving the population of the emissive state...
March 24, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28337630/erratum-to-differential-brain-cognitive-and-motor-profiles-associated-with-partial-trisomy-modeling-down-syndrome-in-mice
#20
Pierre L Roubertoux, Nathalie Baril, Pierre Cau, Christophe Scajola, Adeline Ghata, Catherine Bartoli, Patrice Bourgeois, Julie di Christofaro, Sylvie Tordjman, Michèle Carlier
No abstract text is available yet for this article.
March 23, 2017: Behavior Genetics
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