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https://www.readbyqxmd.com/read/28231612/the-pro-inflammatory-cytokine-tnf-%C3%AE-inhibits-lymphatic-pumping-via-activation-of-the-nf-%C3%AE%C2%BAb-inos-signaling-pathway
#1
Yingxuan Chen, Sonia Rehal, Simon Roizes, Hai-Lei Zhu, William C Cole, Pierre-Yves von der Weid
OBJECTIVE: Mesenteric lymphatic vessels pumping, important to propel lymph and immune cells from the intestinal interstitium to the mesenteric lymph nodes, is compromised during intestinal inflammation. The objective of this study was to test the hypothesis that the pro-inflammatory cytokine tumor necrosis factor alpha (TNF-α), is a significant contributor to the inflammation-induced lymphatic contractile dysfunction, and to determine its mode of action. METHODS: Contractile parameters were obtained form isolated rat mesenteric lymphatic vessels mounted on a pressure myograph after 24-h incubation with or without TNF-α...
February 23, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28231506/plant-chromium-uptake-and-transport-physiological-effects-and-recent-advances-in-molecular-investigations
#2
REVIEW
Maria Angélica da Conceição Gomes, Rachel Ann Hauser-Davis, Marina Satika Suzuki, Angela Pierre Vitória
Increasingly, anthropogenic perturbations of the biosphere manifest in a broad array of global phenomena, causing widespread contamination of most ecosystems, with high dispersion rates of many contaminants throughout different environmental compartments, including metals. Chromium (Cr) contamination in particular, is, increasingly, posing a serious threat to the environment, emerging as a major health hazard to the biota. However, although the molecular and physiological mechanisms of plant responses to many heavy metals, especially lead (Pb) and cadmium (Cd), have been focused upon in recent years, chromium has attracted significantly less attention...
February 20, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28231457/a-butterfly-effect-on-neural-stem-cells
#3
Pierre Vanderhaeghen
Adult neural stem cells originate from the embryonic brain, but the underlying mechanisms remain poorly known. In this issue of Neuron, Falk et al. (2017) reveal how the timely control of cleavage plane orientation during division of embryonic neural progenitors has a specific and long-lasting impact on adult neurogenesis.
February 22, 2017: Neuron
https://www.readbyqxmd.com/read/28231407/co-occurrence-and-hybridization-of-anther-smut-pathogens-specialized-on-dianthus-hosts
#4
Elsa Petit, Casey Silver, Amandine Cornille, Pierre Gladieux, Lisa Rosenthal, Emily Bruns, Sarah Yee, Janis Antonovics, Tatiana Giraud, Michael E Hood
Host specialization has important consequences for the diversification and ecological interactions of obligate pathogens. The anther-smut disease of natural plant populations, caused by Microbotryum fungi, has been characterized by specialized host-pathogen interactions, which contribute in part to the isolation among these numerous fungal species. This study investigated the molecular variation of Microbotryum pathogens within the geographic and host-specific distributions on wild Dianthus species in southern European Alps...
February 23, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28231243/product-development-programs-for-neglected-tropical-diseases-a-crucial-role-for-expert-meetings
#5
Leonie Hussaarts, Kim van der Weijde, Pierre Dome, Elly Kourany-Lefoll, Jutta Reinhard-Rupp, Remco de Vrueh
No abstract text is available yet for this article.
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28231020/could-niv-failure-rates-be-underestimated-in-the-lung-safe-study
#6
Rémi Coudroy, Jean-Pierre Frat, Arnaud W Thille
No abstract text is available yet for this article.
February 23, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28230990/a-comparative-study-of-the-synthesis-structural-and-physicochemical-properties-of-diketopiperazines-vs-aza-diketopiperazines
#7
Pierre Regenass, Damien Bosc, Stéphanie Riché, Patrick Gizzi, Marcel Hibert, Lydia Brelot, A Ganesan, Dominique Bonnet
Aza-diketopiperazines (Aza-DKP) represent an underprivileged motif obtained by scaffold hopping of 2,5-diketopiperazines (2,5-DKP). Herein, we compare the synthesis but also the structural and the physicochemical properties of aza-DKP 4 vs 2,5-DKP 7. Thus, X-ray and 1H NMR studies show that aza-DKP 4 is a rigid and non-flat scaffold like the 2,5-DKP 7. Moreover, the replacement of one Calpha-stereogenic center by a nitrogen atom results in a significant improvement of both the water solubility and the microsomal stability...
February 23, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28230814/m1a%C3%A2-post-transcriptional%C3%A2-modification%C3%A2-in%C3%A2-trnas
#8
REVIEW
Stephanie Oerum, Clément Dégut, Pierre Barraud, Carine Tisné
To date, about 90 post-transcriptional modifications have been reported in tRNA expanding their chemical and functional diversity. Methylation is the most frequent post-transcriptional tRNA modification that can occur on almost all nitrogen sites of the nucleobases, on the C5 atom of pyrimidines, on the C2 and C8 atoms of adenosine and, additionally, on the oxygen of the ribose 2'-OH. The methylation on the N1 atom of adenosine to form 1-methyladenosine (m1A) has been identified at nucleotide position 9, 14, 22, 57, and 58 in different tRNAs...
February 21, 2017: Biomolecules
https://www.readbyqxmd.com/read/28230270/a-phase-2-study-of-lenalidomide-rituximab-cyclophosphamide-and-dexamethasone-lr-cd-for-untreated-low-grade-non-hodgkin-lymphoma-requiring-therapy
#9
Allison Rosenthal, Amylou C Dueck, Stephen Ansell, Katherine Gano, Christopher Conley, Grzegorz S Nowakowski, John Camoriano, Jose F Leis, Joseph R Mikhael, A Keith Stewart, David Inwards, David Dingli, Shaji Kumar, Pierre Noel, Morie Gertz, Luis Porrata, Stephen Russell, Joseph Colgan, Rafael Fonseca, Thomas M Habermann, Prashant Kapoor, Francis Buadi, Nelson Leung, Rodger Tiedemann, Thomas E Witzig, Craig Reeder
Patients with indolent NHL have multiple treatment options yet there is no consensus as to the best initial therapy. Lenalidomide, an immunomodulatory agent, has single agent activity in relapsed lymphoma. This trial was conducted to assess feasibility, efficacy and safety of adding lenalidomide to rituximab, cyclophosphamide, and dexamethasone (LR-CD) in untreated indolent NHL patients requiring therapy. This was a single institution phase II trial. Treatment consisted of IV rituximab 375mg/m(2) day 1, oral lenalidomide 20mg days 1-21, cyclophosphamide 250mg/m(2) days 1, 8, 15, and dexamethasone 40mg days 1, 8, 15, 22, of a 28-day cycle...
February 23, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28230125/seven-temperate-terrestrial-planets-around-the-nearby-ultracool-dwarf-star-trappist-1
#10
Michaël Gillon, Amaury H M J Triaud, Brice-Olivier Demory, Emmanuël Jehin, Eric Agol, Katherine M Deck, Susan M Lederer, Julien de Wit, Artem Burdanov, James G Ingalls, Emeline Bolmont, Jeremy Leconte, Sean N Raymond, Franck Selsis, Martin Turbet, Khalid Barkaoui, Adam Burgasser, Matthew R Burleigh, Sean J Carey, Aleksander Chaushev, Chris M Copperwheat, Laetitia Delrez, Catarina S Fernandes, Daniel L Holdsworth, Enrico J Kotze, Valérie Van Grootel, Yaseen Almleaky, Zouhair Benkhaldoun, Pierre Magain, Didier Queloz
One aim of modern astronomy is to detect temperate, Earth-like exoplanets that are well suited for atmospheric characterization. Recently, three Earth-sized planets were detected that transit (that is, pass in front of) a star with a mass just eight per cent that of the Sun, located 12 parsecs away. The transiting configuration of these planets, combined with the Jupiter-like size of their host star-named TRAPPIST-1-makes possible in-depth studies of their atmospheric properties with present-day and future astronomical facilities...
February 22, 2017: Nature
https://www.readbyqxmd.com/read/28230057/ensemble-and-single-molecule-dynamics-of-ift-dynein-in-caenorhabditis-elegans-cilia
#11
Jona Mijalkovic, Bram Prevo, Felix Oswald, Pierre Mangeol, Erwin J G Peterman
Cytoplasmic dyneins drive microtubule-based, minus-end directed transport in eukaryotic cells. Whereas cytoplasmic dynein 1 has been widely studied, IFT dynein has received far less attention. Here, we use fluorescence microscopy of labelled motors in living Caenorhabditis elegans to investigate IFT-dynein motility at the ensemble and single-molecule level. We find that while the kinesin composition of motor ensembles varies along the track, the amount of dynein remains relatively constant. Remarkably, this does not result in directionality changes of cargo along the track, as has been reported for other opposite-polarity, tug-of-war motility systems...
February 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28229909/paradoxical-inhibition-of-glycolysis-by-pioglitazone-opposes-the-mitochondriopathy-caused-by-aif-deficiency
#12
Paule Bénit, Alice Pelhaître, Elise Saunier, Sylvie Bortoli, Assetou Coulibaly, Malgorzata Rak, Manuel Schiff, Guido Kroemer, Massimo Zeviani, Pierre Rustin
Mice with the hypomorphic AIF-Harlequin mutation exhibit a highly heterogeneous mitochondriopathy that mostly affects respiratory chain complex I, causing a cerebral pathology that resembles that found in patients with AIF loss-of-function mutations. Here we describe that the antidiabetic drug pioglitazone (PIO) can improve the phenotype of a mouse Harlequin (Hq) subgroup, presumably due to an inhibition of glycolysis that causes an increase in blood glucose levels. This glycolysis-inhibitory PIO effect was observed in cultured astrocytes from Hq mice, as well as in human skin fibroblasts from patients with AIF mutation...
February 16, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28229895/impulse-control-disorders-and-levodopa-induced-dyskinesias-in-parkinson-s-disease-an-update
#13
REVIEW
Valerie Voon, T Celeste Napier, Michael J Frank, Veronique Sgambato-Faure, Anthony A Grace, Maria Rodriguez-Oroz, Jose Obeso, Erwan Bezard, Pierre-Olivier Fernagut
Dopaminergic medications used in the treatment of patients with Parkinson's disease are associated with motor and non-motor behavioural side-effects, such as dyskinesias and impulse control disorders also known as behavioural addictions. Levodopa-induced dyskinesias occur in up to 80% of patients with Parkinson's after a few years of chronic treatment. Impulse control disorders, including gambling disorder, binge eating disorder, compulsive sexual behaviour, and compulsive shopping occur in about 17% of patients with Parkinson's disease on dopamine agonists...
March 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28229853/-consideration-of-the-shape-of-the-teeth-in-facial-hyperdivergency
#14
Olivier Sorel, Mohamed Naaim, Pierre-Alexandre Chataigner, Damien Brézulier, Valérie Bertaud
INTRODUCTION: The study examines how the shape of the teeth is taken into account in the context of facial hyperdivergency. One aim was to check out the widely-held belief that the hyperdivergent patient has long teeth. DISCUSSION: Our study found no link between the shape of the teeth and facial hyperdivergency, thus confirming the results in the literature. We examined the issue of how to characterize dental shapes. We found three diversely-appreciated types of shape: rectangular, triangular and ovoid...
March 2017: L' Orthodontie Française
https://www.readbyqxmd.com/read/28229318/contribution-of-computed-tomographic-imaging-to-the-management-of-acute-abdominal-pain-after-gastric-bypass-correlation-between-radiological-and-surgical-findings
#15
Pascale Karila-Cohen, Francesco Cuccioli, Pasquale Tammaro, Anne-Laure Pelletier, Daniel Gero, Jean-Pierre Marmuse, Jean-Pierre Laissy, Konstantinos Arapis
BACKGROUND: We evaluated the diagnostic accuracy of first interpretations of computed tomographic (CT) images and blind interpretation using predefined CT signs in patients with previous Roux-en-Y gastric bypass (RYGBP) and acute abdominal pain. METHODS: We performed a retrospective chart review of patients with RYGBP who underwent surgical exploration from January 2009 to December 2014 for acute abdominal pain in our university institution, excluding patients without CT scan and comparing initial CT imaging interpretation with surgical findings...
February 22, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28229228/new-strains-of-chickpea-chlorotic-dwarf-virus-discovered-on-diseased-papaya-and-tomato-plants-in-burkina-faso
#16
Alassane Ouattara, Fidèle Tiendrébéogo, Pierre Lefeuvre, Murielle Hoareau, Sohini Claverie, Edgar Valentin Traoré, Nicolas Barro, Oumar Traoré, Arvind Varsani, Jean-Michel Lett
This is the first description of full genome sequences of chickpea chlorotic dwarf virus (CpCDV; genus Mastrevirus; family Geminiviridae) identified in papaya and tomato plants sampled in Burkina Faso. The CpCDV full genome sequences from papaya and tomato share the highest pairwise sequence identity (84% and 93.5%) with Sudanese isolates of the CpCDV-K and CpCDV-M strains, respectively. Based on the strain demarcation threshold (>94% identity) for mastreviruses, we propose two new strains, CpCDV-Q and CpCDV-R, identified in papaya and tomato, respectively...
February 22, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28229211/multicenter-international-experience-of-532%C3%A2-nm-laser-photo-vaporization-with-greenlight-xps-in-men-with-large-prostates-prostate-volume%C3%A2-%C3%A2-100%C3%A2-cc
#17
Malek Meskawi, Pierre-Alain Hueber, Roger Valdivieso, Franck Bruyere, Vincent Misrai, Georges Fournier, Ravi Munver, Ganesh Sivarajan, Matthew Rutman, Alexis E Te, Bilal Chughtai, Dean Elterman, Tristan Martel, Mounsif Azizi, Pierre I Karakiewicz, Kevin C Zorn
PURPOSE: To evaluate the outcomes and durability of photoselective vaporization of the prostate (PVP) using the XPS-180 system in patients with a large prostate volume (PV) > 100 cc at 4 years of follow-up in a large, multicenter experience. METHODS: 438 men with pre-operative transrectal ultrasound (TRUS) PV > 100 cc were treated in eight experienced centers in Canada, USA, and in France with the Greenlight XPS laser using PVP for the treatment of symptomatic BPH...
February 22, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28229169/electrophysiological-evidence-for-enhanced-attentional-deployment-in-spatial-learners
#18
Brandi Lee Drisdelle, Kyoko Konishi, Moussa Diarra, Veronique D Bohbot, Pierre Jolicoeur, Greg L West
Visual spatial attention is important during navigation processes that rely on a cognitive map, because spatial relationships between environmental landmarks need to be selected, encoded, and learned. People who navigate using this strategy are spatial learners, and this process relies on the hippocampus. Conversely, response learners memorize a series of actions to navigate, which relies on the caudate nucleus. Response learning, which is more efficient, is thought to involve less demanding cognitive operations, and is related to reduced grey matter in the hippocampus...
February 22, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28228943/a-case-series-of-cholecystectomy-in-jamaican-sickle-cell-disease-patients-the-need-for-a-new-strategy
#19
Pierre-Anthony Leake, Marvin Reid, Joseph Plummer
: High morbidity rates related to cholecystectomy in sickle cell disease (SCD) patients have been previously reported in the region. This study serves to assess the current outcomes related to cholecystectomy in a Jamaican SCD population. METHODS: A retrospective chart review of SCD patients undergoing elective cholecystectomy at the University Hospital of the West Indies over a 6-year period was performed providing relevant information for analysis. Patients were grouped on an intention-to-treat basis into an open and laparoscopic group...
March 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28228911/ultrasonographic-detection-of-air-in-the-superior-sagittal-sinus-in-a-neonate-with-transposition-of-the-great-arteries
#20
Michael D Rivers-Bowerman, Sharon Litz, Pierre Schmit
Cerebral venous air embolism is a relatively rare condition that arises from iatrogenic or traumatic introduction of air into the venous system. We describe the ultrasonographic findings in a 1-day-old infant with iatrogenic retrograde cerebral venous air embolism, which to our knowledge, is the earliest case reported in the literature to date. This case highlights the role of cerebral ultrasonography in the detection and surveillance of cerebral venous air embolism in neonates.
March 2017: Radiology case reports
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