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https://www.readbyqxmd.com/read/29156426/theory-of-mind-and-schizophrenia-in-young-and-middle-aged-patients-influence-of-executive-functions
#1
Marta Croca, Aurèlie Lagodka, Remi Gadel, Marie Chantal Bourdel, Narjes Bendjemaa, Raphael Gaillard, Jean Pierre Olié, M Champagne-Lavau, Marie Odile Krebs, Isabelle Amado
Theory of Mind (ToM) is compromised in schizophrenia, and responsible for social disability. We aim to study the correlation between ToM deficits and Executive Functions (EF), using the Faux Pas Test (FPT) for ToM evaluation, Behavioral Assessment of the Dysexecutive Syndrome (BADS) and Wisconsin Card Sorting Test (WCST) for EF assessment. Two groups of patients with schizophrenia were included: 22 young (18-35 years-old) and 18 middle-aged (>50 years-old) Patients, compared to age-matched Controls. We found worst FPT performances in both groups of patients, but with a more generalized pattern of dysfunction in the middle-aged patient group...
November 17, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29155841/habitat-and-soil-related-drivers-of-the-root-associated-fungal-community-of-quercus-suber-in-the-northern-moroccan-forest
#2
Fatima Zahra Maghnia, Younes Abbas, Frédéric Mahé, Benaissa Kerdouh, Estelle Tournier, Mohamed Ouadji, Pierre Tisseyre, Yves Prin, Naïma El Ghachtouli, Salah Eddine Bakkali Yakhlef, Robin Duponnois, Hervé Sanguin
Soil fungi associated with plant roots, notably ectomycorrhizal (EcM) fungi, are central in above- and below-ground interactions in Mediterranean forests. They are a key component in soil nutrient cycling and plant productivity. Yet, major disturbances of Mediterranean forests, particularly in the Southern Mediterranean basin, are observed due to the greater human pressures and climate changes. These disturbances highly impact forest cover, soil properties and consequently the root-associated fungal communities...
2017: PloS One
https://www.readbyqxmd.com/read/29155816/liposomal-amphotericin-b-in-travelers-with-cutaneous-and-muco-cutaneous-leishmaniasis-not-a-panacea
#3
Romain Guery, Benoit Henry, Guillaume Martin-Blondel, Claire Rouzaud, Florence Cordoliani, Gundel Harms, Jean-Pierre Gangneux, Françoise Foulet, Emmanuelle Bourrat, Michel Baccard, Gloria Morizot, Paul-Henri Consigny, Antoine Berry, Johannes Blum, Olivier Lortholary, Pierre Buffet
BACKGROUND: Complex cutaneous and muco-cutaneous leishmaniasis (CL and MCL) often requires systemic therapy. Liposomal amphotericin B (L-AmB) has a strong potential for a solid clinical benefit in this indication. METHODS: We conducted a retrospective analysis of data from a French centralized referral treatment program and from the "LeishMan" European consortium database. All patients with parasitologically proven CL or MCL who received at least one dose of L-AmB were included...
November 20, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29155361/silver-nanoparticles-increase-bactericidal-activity-and-radical-oxygen-responses-against-bacterial-pathogens-in-human-osteoclasts
#4
Valerie Aurore, Fabienne Caldana, Marianne Blanchard, Solange Kharoubi Hess, Nils Lannes, Pierre-Yves Mantel, Luis Filgueira, Michael Walch
Bone infections are difficult to treat and can lead to severe tissue destruction. Acute bone infections are usually caused by Staphylococcus aureus. Osteoclasts, which belong to the monocyte/macrophage lineage, are the key cells in bone infections. They are not well equipped for killing bacteria and may serve as a reservoir for bacterial pathogens. Silver has been known for centuries for its bactericidal activity. Here, we investigated the bactericidal effects of nano-silver particles in bacteria infected human osteoclasts...
November 16, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29155170/bench-to-bedside-translation-of-dendrimers-reality-or-utopia-a-concise-analysis
#5
Serge Mignani, João Rodrigues, Helena Tomas, René Roy, Xiangyang Shi, Jean-Pierre Majoral
Nanomedicine, which is an application of nanotechnologies in healthcare is developed to improve the treatments and lives of patients suffering from a range of disorders and to increase the successes of drug candidates. Within the nanotechnology universe, the remarkable unique and tunable properties of dendrimers have made them promising tools for diverse biomedical applications such as drug delivery, gene therapy and diagnostic. Up-to-date, very few dendrimers has yet gained regulatory approval for systemic administration, why? In this critical review, we briefly focus on the list of desired basic dendrimer requirements for decision-making purpose by the scientists (go/no-go decision), in early development stages, to become clinical candidates, and to move towards Investigational New Drugs (IND) application submission...
November 16, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29154413/isoindigo-3-4-difluorothiophene-polymer-acceptors-yield-all-polymer-bhj-solar-cells-with-7-efficiency
#6
Shengjian Liu, Yuliar Firdaus, Simil Thomas, Zhipeng Kan, Federico Cruciani, Sergei Lopatin, Jean-Luc M Bredas, Pierre M Beaujuge
Poly(isoindigo-alt-3,4-difluorothiophene) (PIID[2F]T) analogues used as "polymer acceptors" in bulk-heterojunction (BHJ) solar cells achieve >7% efficiency when used in conjunction with the polymer donor PBFTAZ (model system). Considering that most efficient polymer acceptor alternatives to fullerenes (e.g. PC61BM or its C71 derivative) are based on perylenediimide (PDI) or naphthalenediimide (NDI) motifs thus far, branched alkyl-substituted PIID[2F]T polymers are remarkably promising nonfullerene candidates for "all-polymer" BHJ solar cells...
November 20, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29154385/dendrimers-in-combination-with-natural-products-and-analogues-as-anti-cancer-agents
#7
REVIEW
Serge Mignani, João Rodrigues, Helena Tomas, Maria Zablocka, Xiangyang Shi, Anne-Marie Caminade, Jean-Pierre Majoral
For the first time, an overview of dendrimers in combination with natural products and analogues as anti-cancer agents is presented. This reflects the development of drug delivery systems, such as dendrimers, to tackle cancers. The most significant advantages of using dendrimers in nanomedicine are their high biocompatibility, good water solubility, and their entry - with or without encapsulated, complexed or conjugated drugs - through an endocytosis process. This strategy has accelerated over the years in order to develop nanosystems as nanocarriers, to decrease the intrinsic toxicity of anti-cancer agents, to decrease the drug side effects, to increase the efficacy of the treatment, and consequently to improve patient compliance...
November 20, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/29153997/first-investigations-for-the-characterization-of-glucosamine-6-phosphate-synthase-by-capillary-electrophoresis
#8
Miriam Beneito-Cambra, Pierre Gareil, Bernard Badet, Marie-Ange Badet-Denisot, Nathalie Delaunay
The enzyme glucosamine-6-phosphate synthase (GlmS) is an important point of metabolic control in biosynthesis of amino sugar-containing macromolecules and is therefore a potential target in order to design antibacterial and antifungal drugs. It has two oligomerization states, which are the active dimer and the inactive hexamer. For the first time, the potential of CE to separate and quantify the two forms was studied. After incubating GlmS with the d-glucosamine 6-phosphate (GlcN6P) inhibitor, an electrolyte based on sodium phosphate at pH 7...
November 12, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29153977/a-precision-medicine-approach-to-haematological-malignancies
#9
Jean-Pierre Bourquin
No abstract text is available yet for this article.
November 15, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/29153543/-aspirin-and-colorectal-cancer
#10
REVIEW
Adrien Grancher, Pierre Michel, Frédéric Di Fiore, David Sefrioui
Colorectal cancer is a worldwide public health problem. Aspirin has been identified as a protective factor against the apparition of colorectal cancer. There are several mechanisms about the actions by aspirin on colorectal tumorogenesis. These are not perfectly known nowadays. On one hand, there are direct mechanisms on colorectal mucosa, on the other hand there are indirect mechanisms through platelet functions. Aspirin also plays a role by its anti-inflammatory action and the stimulation of antitumor immunity...
November 15, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/29153219/-deployment-of-telemedicine-context-and-challenges
#11
Pierre Espinoza, Camille Jean, Tu Anh Duong
The last decade has contributed to the emergence of telemedicine. Legislation and regulations, new tools, efficient networks and regional deployments have all played their part in its growth. There are several regional solutions, often experimental. The implementation of telemedicine services nevertheless comes up against obstacles which concern all specialities, including cardiology.
November 2017: Soins; la Revue de Référence Infirmière
https://www.readbyqxmd.com/read/29152890/influenza-associated-severe-acute-respiratory-infections-in-two-sentinel-sites-in-lebanon-september-2015-to-august-2016
#12
Majd Saleh, Lara Bazzi, Ebstissam Ismail, Lina Mroueh, Nisrine Jammal, Amgad Elkholy, Pamela Mrad, Ahmad Al Samadi, Ahmad Hijazi, Firass Abiad, Ghazi Nsouli, Alissar Rady, Wasiq Khan, Mamunur Malik, Pierre Zalloua, Walid Ammar, Nada Ghosn
BACKGROUND: Given the sparse information on burden of influenza in Lebanon, the Ministry of Public Health established a sentinel surveillance for Severe Acute Respiratory Infections (SARI) to identify the attribution of influenza to reported cases. We aim to highlight the proportion of influenza-associated SARI from September 1(st) 2015 to August 31(st) 2016 in two Lebanese hospitals. METHODS: The study was conducted in two sentinel sites located in Beirut suburbs and Southern province of Lebanon...
November 20, 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29152797/oxidative-stress-does-not-influence-local-sweat-rate-during-high-intensity-exercise
#13
Robert D Meade, Naoto Fujii, Martin P Poirier, Pierre Boulay, Ronald J Sigal, Glen P Kenny
Nitric oxide (NO)-dependent sweating is diminished during high but not moderate intensity exercise. We evaluated whether this impairment stems from increased oxidative stress during high intensity exercise. On two separate days, 11 young (24 ± 4 years) males cycled in the heat (35°C) at a moderate (500 W; 52 ± 6%VO2peak ) or high (700 W; 71 ± 5%VO2peak ) rate of metabolic heat production. Each session included two 30-min exercise bouts separated by a 20-min recovery. Local sweat rate was monitored at four forearm skin sites continuously perfused via intradermal microdialysis with: (1) lactated Ringer's solution (Control), (2) 10 mm ascorbate (Ascorbate; non-selective antioxidant), (3) 10 mm N(G) -nitro-L -arginine methyl ester (L-NAME; NO synthase inhibitor), or (4) 10 mm Ascorbate + 10 mm L-NAME (Ascorbate + L-NAME)...
November 19, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/29152600/role-of-epinephrine-and-extracorporeal-membrane-oxygenation-in-the-management-of-ischemic-refractory-ventricular-fibrillation-a-randomized-trial-in-pigs
#14
Jason A Bartos, Sebastian Voicu, Timothy R Matsuura, Adamantios Tsangaris, Georgios Sideris, Brett A Oestreich, Stephen A George, Matthew Olson, Kadambari Chandra Shekar, Jennifer N Rees, Kathleen Carlson, Pierre Sebastian, Scott McKnite, Ganesh Raveendran, Tom P Aufderheide, Demetris Yannopoulos
xtracorporeal membrane oxygenation (ECMO) is used in cardiopulmonary resuscitation (CPR) of refractory cardiac arrest. We used a 2×2 study design to compare ECMO versus CPR and epinephrine versus placebo in a porcine model of ischemic refractory ventricular fibrillation (VF). Pigs underwent 5 minutes of untreated VF, 10 minutes of CPR, and were randomized to receive epinephrine versus placebo for another 35 minutes. Animals were further randomized to LAD reperfusion at minute 45 with ongoing CPR versus veno-arterial ECMO cannulation at minute 45 of CPR and subsequent LAD reperfusion...
June 2017: JACC. Basic to Translational Science
https://www.readbyqxmd.com/read/29152510/an-interesting-approach-for-the-diagnosis-of-hepatic-fibrosis-w%C3%A3-ng-et-al-a-combined-use-of-intravoxel-incoherent-motion-mri-parameters-can-differentiate-early-stage-hepatitis-b-fibrotic-livers-from-healthy-livers
#15
EDITORIAL
https://www.readbyqxmd.com/read/29152495/midterm-outcomes-of-titanium-modular-femoral-necks-in-total-hip-arthroplasty
#16
Thurial Collet, Jean-Pierre Atanasiu, Jean-Baptiste de Cussac, Kamal Oufroukhi, Hugo Bothorel, Mo Saffarini, François Badatcheff
Background: Modular femoral necks present surgical and biomechanical advantages in total hip arthroplasty (THA), but their benefits remain controversial due to risks of corrosion and fracture at the additional junction. This study aimed to report 10-year survival and clinical outcomes of a titanium femoral stem with a titanium modular neck in consecutive series. Methods: The authors reviewed the records of 97 patients (99 THAs) using uncemented modular stem and ceramic-on-ceramic acetabular components...
October 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29152461/use-of-toll-like-receptor-assays-for-the-detection-of-bacterial-contaminations-in-icodextrin-batches-released-for-peritoneal-dialysis
#17
Hêla Hacine-Gherbi, Agnès Denys, Mathieu Carpentier, Arnaud Heysen, Pierrick Duflot, Pierre Lanos, Fabrice Allain
Icodextrin is a starch derivative used for preparing solutions of peritoneal dialysis. Unfortunately, peptidoglycans (PGN) and lipopolysaccharides (LPS) have been reported to contaminate certain icodextrin batches and to contribute to the development of sterile peritonitis. The decision of selecting or rejecting icodextrin batches is however difficult, because of limitations in the detection of these bacterial contaminants. Besides monocyte activation tests of cytokine release, a number of bio-assays using stably TLR-transfected cell lines have been developed...
2017: Toxicology Reports
https://www.readbyqxmd.com/read/29152168/pollination-by-the-locally-endangered-island-flying-fox-pteropus-hypomelanus-enhances-fruit-production-of-the-economically-important-durian-durio-zibethinus
#18
Sheema A Aziz, Gopalasamy R Clements, Kim R McConkey, Tuanjit Sritongchuay, Saifful Pathil, Muhammad Nur Hafizi Abu Yazid, Ahimsa Campos-Arceiz, Pierre-Michel Forget, Sara Bumrungsri
Fruit bats provide valuable pollination services to humans through a unique coevolutionary relationship with chiropterophilous plants. However, chiropterophily in the Old World and the pollination roles of large bats, such as flying foxes (Pteropus spp., Acerodon spp., Desmalopex spp.), are still poorly understood and require further elucidation. Efforts to protect these bats have been hampered by a lack of basic quantitative information on their role as ecosystem service providers. Here, we investigate the role of the locally endangered island flying fox Pteropus hypomelanus in the pollination ecology of durian (Durio zibethinus), an economically important crop in Southeast Asia...
November 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29152145/gfap%C3%AE-gfap%C3%AE-ratio-directs-astrocytoma-gene-expression-towards-a-more-malignant-profile
#19
Oscar M J A Stassen, Emma J van Bodegraven, Fabrizio Giuliani, Martina Moeton, Regina Kanski, Jacqueline A Sluijs, Miriam E van Strien, Willem Kamphuis, Pierre A J Robe, Elly M Hol
Astrocytomas are the most common malignant brain tumours and are to date incurable. It is unclear how astrocytomas progress into higher malignant grades. The intermediate filament cytoskeleton is emerging as an important regulator of malignancy in several tumours. The majority of the astrocytomas express the intermediate filament protein Glial Fibrillary Acidic Protein (GFAP). Several GFAP splice variants have been identified and the main variants expressed in human astrocytoma are the GFAPα and GFAPδ isoforms...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29152135/evaluation-of-pre-analytical-conditions-and-comparison-of-the-performance-of-several-digital-pcr-assays-for-the-detection-of-major-egfr-mutations-in-circulating-dna-from-non-small-cell-lung-cancers-the-circan_0-study
#20
Jessica Garcia, Eric Dusserre, Valérie Cheynet, Pierre Paul Bringuier, Karen Brengle-Pesce, Anne-Sophie Wozny, Claire Rodriguez-Lafrasse, Gilles Freyer, Marie Brevet, Léa Payen, Sébastien Couraud
Non invasive somatic detection assays are suitable for repetitive tumor characterization or for detecting the appearance of somatic resistance during lung cancer. Molecular diagnosis based on circulating free DNA (cfDNA) offers the opportunity to track the genomic evolution of the tumor, and was chosen to assess the molecular profile of several EGFR alterations, including deletions in exon 19 (delEX19), the L858R substitution on exon 21 and the EGFR resistance mutation T790M on exon 20. Our study aimed at determining optimal pre-analytical conditions and EGFR mutation detection assays for analyzing cfDNA using the picoliter-droplet digital polymerase chain reaction (ddPCR) assay...
October 20, 2017: Oncotarget
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