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https://www.readbyqxmd.com/read/28544495/posterior-lumbar-interbody-fusion-with-interspinous-fastener-provides-comparable-clinical-outcome-and-fusion-rate-to-pedicle-screws
#1
Wei-Min Huang, Xing-Ming Yu, Xiao-Duo Xu, Ruo-Xian Song, Li-Li Yu, Xiu-Chun Yu
OBJECTIVE: To investigate the clinical feasibility and validity of interspinous fastener (ISF) for lumbar degenerative diseases. METHODS: From October 2013 to March 2014, a total of 46 patients suffering from lumbar degenerative diseases underwent posterior lumbar interbody fusion (PLIF) randomly augmented by ISF or pedicle screws. The clinical outcome was primarily measured by Oswestry Disability Index (ODI) score. The minimal clinical important difference (MCID) was defined as an eight-point decrease in ODI...
May 24, 2017: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28530093/iron-oxide-nanoparticles-powered-micro-optical-coherence-tomography-for-in-situ-imaging-the-penetration-and-swelling-of-polymeric-microneedles-in-skin
#2
Razina Z Seeni, Xiaojun Yu, Hao Chang, Peng Chen, Linbo Liu, Chenjie Xu
In recent years, polymeric microneedles (MNs) have attracted keen interests among researchers for their applicability in transdermal drug delivery and interstitial skin fluid (ISF) extraction. When design and characterize such devices, it is critical to monitor their real-time in vitro and in vivo performances to optimize the desired effects, yet most of the existing methods are incapable of such functions. To address this unmet need, we develop a real-time non-invasive imaging methodology by integrating iron oxide (Fe3O4) nanoparticles into polymeric MNs to enhance image contrast for micro-optical coherence tomography (µOCT) imaging...
May 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28529657/in-situ-pinning-in-slipped-capital-femoral-epiphysis-long-term-follow-up-studies
#3
F Accadbled, J Murgier, B Delannes, J P Cahuzac, J Sales de Gauzy
BACKGROUND: Management of moderately displaced slipped capital femoral epiphysis (SCFE) is debated, mostly because of the risks related to open reduction on one hand, and subsequent evolution toward femoroacetabular impingement (FAI) on the other. METHOD: All SCFE cases treated with in situ fixation (ISF) and a minimum of ten years of follow-up beyond skeletal maturity were analysed in a retrospective multicentre study. Coxometry parameters were measured. Long-term results of ISF were meanwhile analysed at our Institution...
April 2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/28513463/alzheimer-s-disease-against-peptides-products-of-enzymatic-cleavage-app-protein-biological-pathobiological-and-physico-chemical-properties-of-fibrillating-peptides
#4
Małgorzata Marszałek
Various peptides products of enzymatic cleavage of key for Alzheimer's disease Amyloid Precursor Protein (APP) are well known, but still are matter of scientific debate. The Aβ type products are especially challenging for experimental and medical research. This paper outlines several, still poorly known, biological and medical processes such as peptides biology, i.e., formation, biodistribution, translocation, transport and finally removal from brain compartments and body fluids like Intracellular Fluid (ICF), Cerebrospinal Fluid (CSF), Interstitial Fluid (ISF), blood serum or urine...
May 17, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28477083/peritoneal-dialysis-reduces-amyloid-beta-plasma-levels-in-humans-and-attenuates-alzheimer-associated-phenotypes-in-an-app-ps1-mouse-model
#5
Wang-Sheng Jin, Lin-Lin Shen, Xian-Le Bu, Wei-Wei Zhang, Si-Han Chen, Zhi-Lin Huang, Jia-Xiang Xiong, Chang-Yue Gao, Zhifang Dong, Ya-Ni He, Zhi-An Hu, Hua-Dong Zhou, Weihong Song, Xin-Fu Zhou, Yi-Zheng Wang, Yan-Jiang Wang
Clearance of amyloid-beta (Aβ) from the brain is an important therapeutic strategy for Alzheimer's disease (AD). Current studies mainly focus on the central approach of Aβ clearance by introducing therapeutic agents into the brain. In a previous study, we found that peripheral tissues and organs play important roles in clearing brain-derived Aβ, suggesting that the peripheral approach of removing Aβ from the blood may also be effective for AD therapy. Here, we investigated whether peritoneal dialysis, a clinically available therapeutic method for chronic kidney disease (CKD), reduces brain Aβ burden and attenuates AD-type pathologies and cognitive impairments...
May 5, 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/28457009/comparison-of-direct-sampling-and-brochoalveolar-lavage-for-determining-active-drug-concentrations-in-the-pulmonary-epithelial-lining-fluid-of-calves-injected-with-enrofloxacin-or-tilmicosin
#6
D M Foster, H J Sylvester, M G Papich
Antibiotic distribution to interstitial fluid (ISF) and pulmonary epithelial fluid (PELF) was measured and compared to plasma drug concentrations in eight healthy calves. Enrofloxacin (Baytril(®) 100) was administered at a dose of 12.5 mg/kg subcutaneously (SC), and tilmicosin (Micotil(®) 300) was administered at a dose of 20 mg/kg SC. PELF, sampled by two different methods-bronchoalveolar lavage (BAL) and direct sampling (DS)-plasma, and ISF were collected from each calf and measured for tilmicosin, enrofloxacin and its metabolite ciprofloxacin by HPLC...
April 29, 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28456244/inline-screw-feeding-vacuum-arc-thruster
#7
Igal Kronhaus, Matteo Laterza, Yonatan Maor
A new type of micropropulsion device for nanosatellite applications is presented-the inline-screw-feeding vacuum-arc thruster (ISF-VAT). This thruster couples a conventional "triggerless" ignition geometry with a feeding mechanism that maintains a steady state discharge performance. The feeding mechanism implements a screw action on a central cathode rod. At a predetermined rate, a complete and uniform erosion of the cathodes tip is obtained as well as "healing" of the insulator coating. The inline feeding of the cathode forces the arc to emerge on the tip of the cathode, flush with the exit plane of the anode...
April 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28417297/regulation-of-the-glucose-supply-from-capillary-to-tissue-examined-by-developing-a-capillary-model
#8
Akitoshi Maeda, Yukiko Himeno, Masayuki Ikebuchi, Akinori Noma, Akira Amano
A new glucose transport model relying upon diffusion and convection across the capillary membrane was developed, and supplemented with tissue space and lymph flow. The rate of glucose utilization (J util) in the tissue space was described as a saturation function of glucose concentration in the interstitial fluid (C glu,isf), and was varied by applying a scaling factor f to J max. With f = 0, the glucose diffusion ceased within ~20 min. While, with increasing f, the diffusion was accelerated through a decrease in C glu,isf, but the convective flux remained close to resting level...
April 17, 2017: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/28416842/-drainage-characteristic-of-the-brain-interstitial-fluid-detected-by-using-fluorescence-and-magnetic-tracer-method
#9
Y Zhao, Y Q Li, H Y Li, Y L Li, L X Liu, L Yuan, S J Zhang, H B Han
OBJECTIVE: Compare the results of molecular diffusion and mass flow in the interstitial space(ISS) displayed by using optical and magnetic probes and study partitioned drainage of the brain interstitial fluid (ISF). METHODS: In the study, 36 male SD rats were randomly divided into fluorescent inspection group (18), magnetic tracer group (18). Then they were divided equally into caudate nucleus (Cn), thalamus (T) and substantia nigra (Sn) subgroup, 6 rats in each subgroup...
April 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28408252/israeli-spotted-fever-in-sicily-description-of-two-cases-and-minireview
#10
REVIEW
Claudia Colomba, Marcello Trizzino, Anna Giammanco, Celestino Bonura, Danilo Di Bona, Manlio Tolomeo, Antonio Cascio
Mediterranean spotted fever (MSF) is endemic in Italy, where Rickettsia conorii subsp. conorii was thought to be the only pathogenic rickettsia and Rhipicephalus sanguineus the vector and main reservoir. R. conorii subsp. israelensis, which belongs to the R. conorii complex, is the agent of Israeli spotted fever (ISF); apart from Israel, it has also been found in Italy (Sicily and Sardinia) and in different regions of Portugal. We describe here two severe cases of ISF which occurred in otherwise healthy Italian adults...
April 10, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28392242/development-of-microdialysis-methodology-for-interstitial-insulin-measurement-in-rodents
#11
Ann E Griffin, Ruth Macdonald, Anton J M Wagenmakers, Janice M Marshall, Simon M Poucher
INTRODUCTION: Accurate assessment of muscle insulin sensitivity requires measurement of insulin concentration in interstitial fluid (ISF), but has proved difficult. We aimed to optimise measurement of ISF insulin concentrations in rat muscles in vivo using microdialysis. METHODS: Factorial experimental design experiments were performed in vitro to determine optimal conditions for insulin recovery with microdialysis probes. These conditions were tested in vivo, adjusted appropriately and used in lean and obese Zucker rats to compare ISF insulin concentrations basally and during hyperinsulinaemic-euglycaemic (HE) clamp...
April 6, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/28389645/enhanced-interstitial-fluid-drainage-in-the-hippocampus-of-spontaneously-hypertensive-rats
#12
Beatrice Bedussi, Daphne M P Naessens, Judith de Vos, Rik Olde Engberink, Micha M M Wilhelmus, Edo Richard, Malyssa Ten Hove, Ed vanBavel, Erik N T P Bakker
Hypertension is associated with cognitive decline and various forms of dementia, including Alzheimer's disease. In animal models of hypertension, many of Alzheimer's disease characteristics are recapitulated, including brain atrophy, cognitive decline, amyloid β accumulation and blood brain barrier dysfunction. Removal of amyloid β and other waste products depends in part on clearance via the brain interstitial fluid (ISF). Here we studied the impact of hypertension on ISF drainage, using spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY)...
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28371848/negative-effect-of-malocclusion-on-the-emotional-and-social-well-being-of-brazilian-adolescents-a-population-based-study
#13
Jéssica Madeira Bittencourt, Letícia Pereira Martins, Cristiane Baccin Bendo, Miriam Pimenta Vale, Saul Martins Paiva
Background/objectives: The aesthetic impact of malocclusion can have negative repercussions on quality of life, social interaction, interpersonal relationships, and psychological well-being. The aim of this study was to evaluate the impact of malocclusion on the quality of life of Brazilian adolescents. Methods: A representative cross-sectional study of 1612 adolescents from Belo Horizonte, Minas Gerais was conducted. The adolescents responded to the Brazilian version of the Child Perception Questionnaire (CPQ11-14-ISF:16) to assess the impact of the condition on quality of life...
March 25, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/28350080/homeostasis-and-the-concept-of-interstitial-fluids-hierarchy-relevance-of-cerebrospinal-fluid-sodium-concentrations-and-brain-temperature-control%C3%A2-review
#14
Luigi F Agnati, Manuela Marcoli, Giuseppina Leo, Guido Maura, Diego Guidolin
In this review, the aspects and further developments of the concept of homeostasis are discussed also in the perspective of their possible impact in the clinical practice, particularly as far as psychic homeostasis is concerned. A brief historical survey and comments on the concept of homeostasis and allostasis are presented to introduce our proposal that is based on the classical assumption of the interstitial fluid (ISF) as the internal medium for multicellular organisms. However, the new concept of a hierarchic role of ISF of the various organs is introduced...
February 3, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28332406/continuous-glucose-monitor-interference-with-commonly-prescribed-medications
#15
Ananda Basu, Michael Q Slama, Wayne T Nicholson, Loralie Langman, Thomas Peyser, Rickey Carter, Rita Basu
BACKGROUND: Reliability of continuous glucose monitors (CGM) is a prerequisite for therapeutic dosing of insulin without the need for confirmatory blood glucose meter measurements. Interference of CGMs with commonly prescribed substances has not been extensively evaluated. METHODS: We sought to undertake a novel pilot study to determine the susceptibility of FDA-approved CGM systems (Medtronic Guardian Sof-Sensor, Dexcom G4 Platinum) to erroneous readings in the presence of common medications...
March 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28328234/quantification-of-basal-insulin-peglispro-and-human-insulin-in-adipose-tissue-interstitial-fluid-by-open-flow-microperfusion
#16
Katrin Tiffner, Beate Boulgaropoulos, Christian Höfferer, Thomas Birngruber, Niels Porksen, Helle Linnebjerg, Parag Garhyan, Eric Chen Quin Lam, Mary Pat Knadler, Thomas R Pieber, Frank Sinner
BACKGROUND: Restoration of the physiologic hepatic-to-peripheral insulin gradient may be achieved by either portal vein administration or altering insulin structure to increase hepatic specificity or restrict peripheral access. Basal insulin peglispro (BIL) is a novel, PEGylated basal insulin with a flat pharmacokinetic and glucodynamic profile and altered hepatic-to-peripheral action gradient. We hypothesized reduced BIL exposure in peripheral tissues explains the latter, and in this study assessed the adipose tissue interstitial fluid (ISF) concentrations of BIL compared with human insulin (HI)...
May 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28324208/the-%C3%AE-subunit-of-%C3%AE-conglycinin-and-various-glycinin-subunits-of-soy-are-not-required-to-modulate-hepatic-lipid-metabolism-in-rats
#17
Cynthia Chatterjee, Jiajie Liu, Carla Wood, Christine Gagnon, Elroy R Cober, Judith A Frégeau-Reid, Stephen Gleddie, Chao-Wu Xiao
PURPOSE: This study examined the effect of soy proteins with depletion of different subunits of the two major storage proteins, β-conglycinin and glycinin, on hepatic lipids and proteins involved in lipid metabolism in rats, since the bioactive component of soy responsible for lipid-lowering is unclear. METHODS: Weanling Sprague Dawley rats were fed diets containing either 20% casein protein in the absence (casein) or presence (casein + ISF) of isoflavones or 20% alcohol-washed soy protein isolate (SPI) or 20% soy protein concentrates derived from a conventional (Haro) or 2 soybean lines lacking the α' subunit of β-conglycinin and the A1-3 (1TF) or A1-5 (1a) subunits of glycinin...
March 21, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28323163/cerebrospinal-and-interstitial-fluid-transport-via-the-glymphatic-pathway-modeled-by-optimal-mass-transport
#18
Vadim Ratner, Yi Gao, Hedok Lee, Rena Elkin, Maiken Nedergaard, Helene Benveniste, Allen Tannenbaum
The glymphatic pathway is a system which facilitates continuous cerebrospinal fluid (CSF) and interstitial fluid (ISF) exchange and plays a key role in removing waste products from the rodent brain. Dysfunction of the glymphatic pathway may be implicated in the pathophysiology of Alzheimer's disease. Intriguingly, the glymphatic system is most active during deep wave sleep general anesthesia. By using paramagnetic tracers administered into CSF of rodents, we previously showed the utility of MRI in characterizing a macroscopic whole brain view of glymphatic transport but we have yet to define and visualize the specific flow patterns...
May 15, 2017: NeuroImage
https://www.readbyqxmd.com/read/28322063/discrepancies-between-blood-glucose-and-interstitial-glucose-technological-artifacts-or-physiology
#19
Thorsten Siegmund, Lutz Heinemann, Ralf Kolassa, Andreas Thomas
BACKGROUND: For decades, the major source of information used to make therapeutic decisions by patients with diabetes has been glucose measurements using capillary blood samples. Knowledge gained from clinical studies, for example, on the impact of metabolic control on diabetes-related complications, is based on such measurements. Different to traditional blood glucose measurement systems, systems for continuous glucose monitoring (CGM) measure glucose in interstitial fluid (ISF). The assumption is that glucose levels in blood and ISF are practically the same and that the information provided can be used interchangeably...
March 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28298456/microglial-complement-receptor-3-regulates-brain-a%C3%AE-levels-through-secreted-proteolytic-activity
#20
Eva Czirr, Nicholas A Castello, Kira I Mosher, Joseph M Castellano, Izumi V Hinkson, Kurt M Lucin, Bernat Baeza-Raja, Jae Kyu Ryu, Lulin Li, Sasha N Farina, Nadia P Belichenko, Frank M Longo, Katerina Akassoglou, Markus Britschgi, John R Cirrito, Tony Wyss-Coray
Recent genetic evidence supports a link between microglia and the complement system in Alzheimer's disease (AD). In this study, we uncovered a novel role for the microglial complement receptor 3 (CR3) in the regulation of soluble β-amyloid (Aβ) clearance independent of phagocytosis. Unexpectedly, ablation of CR3 in human amyloid precursor protein-transgenic mice results in decreased, rather than increased, Aβ accumulation. In line with these findings, cultured microglia lacking CR3 are more efficient than wild-type cells at degrading extracellular Aβ by secreting enzymatic factors, including tissue plasminogen activator...
April 3, 2017: Journal of Experimental Medicine
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