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https://www.readbyqxmd.com/read/29334198/enzyme-based-glucose-sensor-from-invasive-to-wearable-device
#1
REVIEW
Hyunjae Lee, Yongseok Joseph Hong, Seungmin Baik, Taeghwan Hyeon, Dae-Hyeong Kim
Blood glucose concentration is a key indicator of patients' health, particularly for symptoms associated with diabetes mellitus. Because of the large number of diabetic patients, many approaches for glucose measurement have been studied to enable continuous and accurate glucose level monitoring. Among them, electrochemical analysis is prominent because it is simple and quantitative. This technology has been incorporated into commercialized and research-level devices from simple test strips to wearable devices and implantable systems...
January 15, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29323762/pentacene-dimers-as-a-critical-tool-for-the-investigation-of-intramolecular-singlet-fission
#2
Constantin Hetzer, Dirk Guldi, Rik R Tykwinski
Singlet fission (SF) involves the spontaneous splitting of a photoexcited singlet state into a pair of triplets, and it holds great promise toward the realization of more efficient solar cells. Although the process of SF has been known since the 1960s, debate regarding the underlying mechanism continues to this day, especially for molecular materials. A number of different chromophores have been synthesized and studied in order to better understand the process of SF. These previous reports have established that pentacene and its derivatives are especially well suited for the study of SF, since the energetic requirement E(S1) ≥ 2E(T1) is fulfilled rendering the process exothermic and unidirectional...
January 11, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29306627/favourable-outcomes-of-endovascular-total-aortic-arch-repair-via-needle-based-in-situ-fenestration-at-a-mean-follow-up-of-5-4%C3%A2-months
#3
Tao Shang, Lu Tian, Dong-Lin Li, Zi-Heng Wu, Hong-Kun Zhang
OBJECTIVES: Endovascular repair of aortic arch pathologies remains challenging. Recently, needle based in situ fenestration (ISF) has shown great potential in endovascular total aortic arch repair (ETAAR). This study aimed to evaluate the feasibility, effectiveness, and safety of ETAAR via needle based ISF, and to present initial experience with this technique. DESIGN AND METHODS: Patients who met the inclusion criteria were enrolled in this prospective study. The supra-arch branches were manually punctured in a retrograde manner using liver biopsy needles (18 gauge/30 cm) in the left common carotid artery (LCCA) and brachiocephalic trunk (BCT), and endo-puncture system or aspiration biopsy needles (21-gauge) in the left subclavian artery (LSA)...
January 3, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29285346/subject-specific-multi-poroelastic-model-for-exploring-the-risk-factors-associated-with-the-early-stages-of-alzheimer-s-disease
#4
Liwei Guo, John C Vardakis, Toni Lassila, Micaela Mitolo, Nishant Ravikumar, Dean Chou, Matthias Lange, Ali Sarrami-Foroushani, Brett J Tully, Zeike A Taylor, Susheel Varma, Annalena Venneri, Alejandro F Frangi, Yiannis Ventikos
There is emerging evidence suggesting that Alzheimer's disease is a vascular disorder, caused by impaired cerebral perfusion, which may be promoted by cardiovascular risk factors that are strongly influenced by lifestyle. In order to develop an understanding of the exact nature of such a hypothesis, a biomechanical understanding of the influence of lifestyle factors is pursued. An extended poroelastic model of perfused parenchymal tissue coupled with separate workflows concerning subject-specific meshes, permeability tensor maps and cerebral blood flow variability is used...
February 6, 2018: Interface Focus
https://www.readbyqxmd.com/read/29274994/zn-isotopes-fractionation-during-slags-weathering-one-source-of-contamination-multiple-isotopic-signatures
#5
Nang-Htay Yin, Eric D van Hullebusch, Marc Benedetti, Piet N L Lens, Yann Sivry
During the chemical weathering of lead blast furnace (LBF) and imperial smelting furnace (ISF) slags, possible Zn isotopes fractionation was studied as a function of pH, atmosphere (open air vs nitrogen), and time. Bulk LBF and ISF displayed heavier signatures compared to Johnson Matthey Company (JMC) Zn standard solution (i.e. 0.13 ± 0.06‰ and 0.78 ± 0.13‰ for LBF and ISF, resp). The Zn signatures vary greatly by changes in solution pH; heavier signatures at low pH and lighter signature at high pH...
December 12, 2017: Chemosphere
https://www.readbyqxmd.com/read/29211004/a-skylight-simulator-for-hwil-simulation-of-hyperspectral-remote-sensing
#6
Huijie Zhao, Bolun Cui, Guorui Jia, Xudong Li, Chao Zhang, Xinyang Zhang
Even though digital simulation technology has been widely used in the last two decades, hardware-in-the-loop (HWIL) simulation is still an indispensable method for spectral uncertainty research of ground targets. However, previous facilities mainly focus on the simulation of panchromatic imaging. Therefore, neither the spectral nor the spatial performance is enough for hyperspectral simulation. To improve the accuracy of illumination simulation, a new dome-like skylight simulator is designed and developed to fit the spatial distribution and spectral characteristics of a real skylight for the wavelength from 350 nm to 2500 nm...
December 6, 2017: Sensors
https://www.readbyqxmd.com/read/29195051/the-glymphatic-system-in-central-nervous-system-health-and-disease-past-present-and-future
#7
Benjamin A Plog, Maiken Nedergaard
The central nervous system (CNS) is unique in being the only organ system lacking lymphatic vessels to assist in the removal of interstitial metabolic waste products. Recent work has led to the discovery of the glymphatic system, a glial-dependent perivascular network that subserves a pseudolymphatic function in the brain. Within the glymphatic pathway, cerebrospinal fluid (CSF) enters the brain via periarterial spaces, passes into the interstitium via perivascular astrocytic aquaporin-4, and then drives the perivenous drainage of interstitial fluid (ISF) and its solute...
December 1, 2017: Annual Review of Pathology
https://www.readbyqxmd.com/read/29194222/risk-factors-for-admission-and-prolonged-length-of-stay-in-pediatric-isolated-skull-fractures
#8
Daniel C Williams, Anbesaw W Selassie, William S Russell, Keith T Borg, William T Basco
OBJECTIVES: This study aimed to assess management of pediatric isolated skull fracture (ISF) patients by determining frequency of admission and describing characteristics associated with patients admitted for observation compared with patients discharged directly from the emergency department (ED) and those requiring a prolonged hospitalization. METHODS: We evaluated children younger than 5 years who presented with ISF using the South Carolina Traumatic Brain Injury Surveillance and Registry System data from 2001 to 2011...
December 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29189590/management-of-pediatric-isolated-skull-fractures-a-decision-tree-and-cost-analysis-on-emergency-department-disposition-strategies
#9
Daniel C Williams, W Scott Russell, Annie L Andrews, Kit N Simpson, William T Basco, Ronald J Teufel
OBJECTIVE: Pediatric isolated skull fractures (ISFs) are common injuries that represent challenging disposition decisions for clinicians. The purpose of this study is to use a decision analysis to compare the clinical and cost-effectiveness of 3 emergency department (ED)-based disposition scenarios for a pediatric patient presenting with ISF. METHODS: We conducted a cost-effectiveness analysis comparing ED disposition scenarios that included current practice, increased at-home surveillance, and observation unit utilization...
November 20, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29188114/optical-surface-plasmon-resonance-sensor-modified-by-mutant-glucose-galactose-binding-protein-for-affinity-detection-of-glucose-molecules
#10
Dachao Li, Jie Su, Jia Yang, Songlin Yu, Jingxin Zhang, Kexin Xu, Haixia Yu
Transdermal extraction of interstitial fluid (ISF) offers an attractive method for minimally invasive blood glucose monitoring. However, only a minute volume of ISF could be transdermally extracted, which is required to be diluted to form a manipulable volume of fluid for easy collection, transportation, and glucose detection. Therefore, a high-resolution glucose detection method is required for detecting glucose concentration in diluted ISF. In this paper, an optical surface plasmon resonance (SPR) sensor modified by the glucose/galactose-binding (GGB) protein which has good affinity to glucose molecules was presented for specific and sensitive glucose detection...
November 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/29183834/contact-lens-to-measure-individual-ion-concentrations-in-tears-and-applications-to-dry-eye-disease
#11
Ramachandram Badugu, Bennie H Jeng, E Albert Reece, Joseph R Lakowicz
Dry eye disease (DED) affects millions of individuals in the United States and worldwide, and the incidence is increasing with an aging population. There is widespread agreement that the measurement of total tear osmolarity is the most reliable test, but this procedure provides only the total ionic strength and does not provide the concentration of each ionic species in tears. Here, we describe an approach to determine the individual ion concentrations in tears using modern silicone hydrogel (SiHG) contact lenses...
November 25, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/29172549/proteomic-characterization-of-dermal-interstitial-fluid-extracted-using-a-novel-microneedle-assisted-technique
#12
Bao Quoc Tran, Philip R Miller, Robert M Taylor, Gabrielle Boyd, Phillip M Mach, C Nicole Rosenzweig, Justin T Baca, Ronen Polsky, Trevor Glaros
As commercial wearable fitness devices have gained commercial acceptance, interest in-real time monitoring of an individual's physiological status using non-invasive techniques has grown. Microneedles have been proposed as a minimally invasive technique for sampling the dermal interstitial fluid (ISF) for clinical monitoring and diagnosis, but little is known about its composition. In this study, dermal ISF was collected using novel microneedle array from three healthy human donors and compared to matching serum and plasma samples...
November 24, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29163074/the-paravascular-pathway-for-brain-waste-clearance-current-understanding-significance-and-controversy
#13
REVIEW
Andrew Bacyinski, Maosheng Xu, Wei Wang, Jiani Hu
The paravascular pathway, also known as the "glymphatic" pathway, is a recently described system for waste clearance in the brain. According to this model, cerebrospinal fluid (CSF) enters the paravascular spaces surrounding penetrating arteries of the brain, mixes with interstitial fluid (ISF) and solutes in the parenchyma, and exits along paravascular spaces of draining veins. Studies have shown that metabolic waste products and solutes, including proteins involved in the pathogenesis of neurodegenerative diseases such as amyloid-beta, may be cleared by this pathway...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/29149914/testing-the-effectiveness-of-a-motivational-interviewing-based-brief-intervention-for-substance-use-as-an-adjunct-to-usual-care-in-community-based-aids-service-organizations-study-protocol-for-a-multisite-randomized-controlled-trial
#14
Bryan R Garner, Heather J Gotham, Stephen J Tueller, Elizabeth L Ball, David Kaiser, Patricia Stilen, Kathryn Speck, Denna Vandersloot, Traci R Rieckmann, Michael Chaple, Erika G Martin, Steve Martino
BACKGROUND: In 2010, the first comprehensive National HIV/AIDS Strategy for the United States was released and included three goals: (1) reducing the number of people who become infected with HIV, (2) increasing access to care and improving health outcomes for people living with HIV, and (3) reducing HIV-related health disparities and health inequities. In 2013, as part of its effort to help address the National HIV/AIDS Strategy, the National Institute on Drug Abuse (NIDA) funded a type 2 effectiveness-implementation hybrid trial titled the Substance Abuse Treatment to HIV Care (SAT2HIV) Project...
November 17, 2017: Addiction Science & Clinical Practice
https://www.readbyqxmd.com/read/29149909/testing-the-implementation-and-sustainment-facilitation-isf-strategy-as-an-effective-adjunct-to-the-addiction-technology-transfer-center-attc-strategy-study-protocol-for-a-cluster-randomized-trial
#15
Bryan R Garner, Mark Zehner, Mathew R Roosa, Steve Martino, Heather J Gotham, Elizabeth L Ball, Patricia Stilen, Kathryn Speck, Denna Vandersloot, Traci R Rieckmann, Michael Chaple, Erika G Martin, David Kaiser, James H Ford
BACKGROUND: Improving the extent to which evidence-based practices (EBPs)-treatments that have been empirically shown to be efficacious or effective-are integrated within routine practice is a well-documented challenge across numerous areas of health. In 2014, the National Institute on Drug Abuse funded a type 2 effectiveness-implementation hybrid trial titled the substance abuse treatment to HIV Care (SAT2HIV) Project. Aim 1 of the SAT2HIV Project tests the effectiveness of a motivational interviewing-based brief intervention (MIBI) for substance use as an adjunct to usual care within AIDS service organizations (ASOs) as part of its MIBI Experiment...
November 17, 2017: Addiction Science & Clinical Practice
https://www.readbyqxmd.com/read/29060694/a-computational-model-of-myocardial-microcirculation-including-interstitial-flow
#16
Takao Shimayoshi, Yuta Yamamoto, Tetsuya Matsuda
Contributions of interstitial fluid (ISF) flow within the myocardial microcirculation is not well understood despite its importance due to difficulties in measurements. For analysing a contribution of interstitial fluid flow within myocardial microcirculation, we developed a computational model of myocardial microcirculation by introducing convection by the ISF flow into an existing myocardial microcirculation model, and performed simulations with varied ISF flows in normal and hypoperfusion conditions. Simulation results show that the ISF flow has a contribution only with low capillary flow...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29032117/protective-effects-of-salvia-miltiorrhiza-on-adenine-induced-chronic-renal-failure-by-regulating-the-metabolic-profiling-and-modulating-the-nadph-oxidase-ros-erk-and-tgf-%C3%AE-smad-signaling-pathways
#17
Hongdie Cai, Shulan Su, Yonghui Li, Huiting Zeng, Zhenhua Zhu, Jianming Guo, Yue Zhu, Sheng Guo, Li Yu, Dawei Qian, Yuping Tang, Jinao Duan
ETHNOPHARMACOLOGICAL RELEVANCE: Chronic renal failure (CRF) is defined as a progressive and irreversible loss of renal function and associated with inflammation and oxidative stress. Salvia miltiorrhiza (SM) is an important Chinese herb used in traditional Chinese medicine for treating cardiovascular diseases. The previous studies showed the SM exhibited significant protective effects on CRF. In this present study, the metabolic profiling changes and action mechanism of SM on CRF were explored...
October 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29019915/revolutionizing-therapeutic-drug-monitoring-with-the-use-of-interstitial-fluid-and-microneedles-technology
#18
REVIEW
Tony K L Kiang, Sahan A Ranamukhaarachchi, Mary H H Ensom
While therapeutic drug monitoring (TDM) that uses blood as the biological matrix is the traditional gold standard, this practice may be impossible, impractical, or unethical for some patient populations (e.g., elderly, pediatric, anemic) and those with fragile veins. In the context of finding an alternative biological matrix for TDM, this manuscript will provide a qualitative review on: (1) the principles of TDM; (2) alternative matrices for TDM; (3) current evidence supporting the use of interstitial fluid (ISF) for TDM in clinical models; (4) the use of microneedle technologies, which is potentially minimally invasive and pain-free, for the collection of ISF; and (5) future directions...
October 11, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/28990825/perceived-stress-and-intent-to-die-in-young-soldiers-who-attempt-suicide
#19
Leah Shelef, Anat Brunstein Klomek, Nirit Yavnai, Golan Shahar
BACKGROUND: Intent to die is an important component of suicide risk assessment. The authors compared the predictive effect of two forms of stress - military and perceived - in intent to die by suicide among young adult Israeli soldiers with a history of suicide attempts. Depression, suicide ideation, and habituation/acquired capacity for suicidality served as covariates. METHODS: Participants were 60 young adult soldiers in the Israeli Defense Force (ISF; aged 18-21 years), who made a suicide attempt during their military service...
October 6, 2017: Crisis
https://www.readbyqxmd.com/read/28970200/wearable-physiological-systems-and-technologies-for-metabolic-monitoring
#20
Wei Gao, George A Brooks, David C Klonoff
Wearable sensors allow continuous monitoring of metabolites for diabetes, sports medicine, exercise science, and physiology research. These sensors can continuously detect target analytes in skin interstitial fluid (ISF), tears, saliva, and sweat. In this review, we will summarize developments on wearable devices and their potential applications in research, clinical practice, and recreational and sporting activities. Sampling skin ISF can require insertion of a needle into the skin, whereas sweat, tears, and saliva can be sampled by devices worn outside the body...
September 28, 2017: Journal of Applied Physiology
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